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TDMS Study 05007-05 Pathology Tables

NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97
Route: DOSED FEED                                                                                                 Time: 08:05:11




       Facility:  Southern Research Institute

       Chemical CAS #:  9005-65-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|             
                                           | 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |             
      Infiltration Cellular, Lymphocyte    |       2  2  2     2  1  2                    1                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +               |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +               |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +               |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Fatty Change                         |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |    4  1                                               1                  |             
      Infiltration Cellular, Lymphocyte    |          2        2           2  2     2        1  2  2  2               |             
      Inflammation, Acute                  | 2                                                                        |             
      Necrosis                             | 2                                                                        |             
      Vacuolization Cytoplasmic            |                                                    2                     |             
      Hepatocyte, Hyperplasia              |                                                          2               |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +              +                                      +               |             
      Inflammation, Acute                  | 3                                                                        |             
      Inflammation, Chronic Active         |    3                                                                     |             
      Fat, Necrosis                        |                   2                                      3               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +               |             
      Abscess                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2  2              2  2              2     2     2  2  2               |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      | 2                                               4                        |             
      Duct, Ectasia                        |                                                 3                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2        2  2  2  2     2  2  3  2  2  2  2  2  2               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia, Squamous                |          1                                                               |             
      Infiltration Cellular, Lymphocyte    |                                           1                              |             
      Inflammation, Acute                  |    2                                                                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                   1              1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|             
                                           | 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |       2  2  2                                            2               |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                              2     2                     |             
      Mucosa, Ectasia                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |       1                             2     2              2               |             
      Inflammation, Acute                  | 1                                                                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Ventricle, Thrombosis                |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Capsule, Inflammation, Chronic Active|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                          X               |             
      Degeneration, Fatty                  |                                                          2               |             
      Hyperplasia                          |                                     2                                    |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         | 1     2  2  2        1  2  2     2  2  2  2     2  1  2  2               |             
      Spindle Cell, Hyperplasia            | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  3  2  2  2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |                                                          2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  M  +               |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           | 2                                                                        |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                              X                           |             
      Pars Distalis, Hyperplasia           |             2     2                    2           1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |       2  1                                                               |             
      Follicle, Ectasia                    |                      3  2                    2                           |             
      Follicle, Hyperplasia                |             1                                                            |             
      Follicular Cell, Ectasia             |                                        2        2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|             
                                           | 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M               |             
      Abscess                              | 4  4           4                          4                              |             
      Angiectasis                          |                                                 2                        |             
      Hemorrhage                           |                                                       3                  |             
      Mineralization                       |                                                                          |             
      Follicle, Cyst                       |             X              X                                             |             
      Periovarian Tissue, Cyst             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Abscess                              |                               4                                          |             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3     3  4  3     3  3  3  3     3  3  3  3  3  2  3  3  3               |             
      Endometrium, Inflammation, Acute     | 3  4                                      3              3               |             
      Endometrium, Metaplasia, Squamous    |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Angiectasis                          |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Myelofibrosis                        |    2        2        3  3  2           2        3  3  3                  |             
      Myeloid Cell, Hyperplasia            | 4  2  2  2  2     2     2  2  2  2     2  2  2  2     2  2               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |             
      Iliac, Hyperplasia, Lymphoid         |    3                                                                     |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |    3                                                                     |             
      Renal, Inflammation, Acute           | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia, Lymphoid                | 2  2  2  3  2     2  3  2  2     2  2  2     2  2  2  2                  |             
      Pigmentation                         | 2           2     2  2  2                 2  2        2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +               |             
      Angiectasis                          |                                                                          |             
      Congestion                           |       2                                                                  |             
      Hyperplasia, Lymphoid                |       2     2     2  3                       2     3                     |             
      Inflammation, Acute                  | 2  3                                                                     |             
      Pigmentation                         |                                                 1                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hematopoietic Cell Proliferation     | 3  4  2  2  2     3  2  2  3  2  3     2  3  2  3  3  2  2               |             
      Hyperplasia, Lymphoid                |       2     2        2           2     2     2     2     2               |             
      Inflammation, Acute                  | 3  3                                                                     |             
      Pigmentation                         |       2  2        1  1  2                    2  2        2               |             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cyst                                 |                                  X           X  X  X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|             
                                           | 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |    2        2     2  2                       2     3  2                  |             
      Inflammation, Acute                  | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Acinus, Ectasia                      |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Chronic                | 2  2  2  3  2     1  1     1              2     1        1               |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Multifocal             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mineralization                       |    1  2  2                       2           2  2        2               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Abscess                              |                                                                          |             
      Congestion                           |                2                    3                                    |             
      Hemorrhage                           |                            1                                             |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  2  1  2  2  2  1  2  2  2     2  2  2  2  2               |             
      Alveolar Epithelium, Hyperplasia     |                         2              2                                 |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                         2                                                |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
      Interstitium, Inflammation, Acute    | 2  2                                                                     |             
      Mediastinum, Atypia Cellular         |                                                                          |             
      Mediastinum, Inflammation, Acute     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +               |             
      Lumen, Hemorrhage                    |             2     1  2  2  2           2        2  1  1                  |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Nasolacrimal Duct, Hemorrhage        |          2                                   2                           |             
      Olfactory Epithelium, Degeneration   | 2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2               |             
      Respiratory Epithelium, Degeneration |                         2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 4| 4| 4| 4|             
                             DAY ON TEST   | 3| 3| 2| 2| 2| 8| 2| 2| 2| 2| 1| 8| 9| 2| 2| 0| 0| 2| 2| 2| 5| 5| 5| 5| 5|             
                                           | 6| 6| 9| 9| 9| 0| 9| 9| 9| 9| 4| 3| 6| 9| 9| 9| 7| 9| 9| 9| 5| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2     2  2     2  2  2  2  2  2  2  2  2  2  2               |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Capsule, Inflammation, Chronic Active|                                                                          |             
      Renal Tubule, Casts Protein          | 1  2              1                 2                                    |             
      Renal Tubule, Ectasia                | 1  2     1        1  1              1     2                              |             
      Renal Tubule, Mineralization         | 2                                                                        |             
      Renal Tubule, Necrosis               |       1  1              2              2                 1               |             
      Renal Tubule, Regeneration           | 1     2  2  2              1                    1  2     1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |                   2        2     2  2  2              2  2               |             
      Inflammation, Acute                  |                                                                          |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|             
                                           | 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |          2  2     2  2  1              2  2        2  2                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Fatty Change                         |                                           2                              |             
      Focal Cellular Change                |                                  X                                       |             
      Hematopoietic Cell Proliferation     | 2  2           2  2  3  2  2     1     2     2        2  2               |             
      Infiltration Cellular, Lymphocyte    |       2  2  1     2     2        1                 2  2                  |             
      Inflammation, Acute                  |                               2              2                           |             
      Necrosis                             | 2                                                                        |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                          +  +  +        +                           |             
      Inflammation, Acute                  |                               3  4           4                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Abscess                              |                                              4                           |             
      Infiltration Cellular, Lymphocyte    |    2  2     2  2  1     1              2           1                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Ectasia                        |                                     3                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |    2        2  2  2  2  2  2  2        2  2     1  2  2  2               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia, Squamous                |                   3                                      3               |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Acute                  |                      2                                                   |             
      Inflammation, Chronic Active         |                   3                                                      |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|             
                                           | 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |    2        2     2                    2  2  2     2  2                  |             
      Inflammation, Chronic Active         |                   2                                                      |             
      Mineralization                       |       2                                                                  |             
      Mucosa, Ectasia                      |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |          2  1                          1  2        1                     |             
      Inflammation, Acute                  |                                  2           2                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Ventricle, Thrombosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Capsule, Inflammation, Chronic Active|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |          2                                                               |             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia                          |                                     2                                    |             
      Inflammation, Acute                  |                                              1                           |             
      Pigmentation                         |       2  2  2  2        2  2        2  2  2        2  2  2               |             
      Spindle Cell, Hyperplasia            | 3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  M  M  M  M  M  +  M  +  +  +  +  M  M  M  M               |             
      Infiltration Cellular, Lymphocyte    |                                           2                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +               |             
      Congestion                           |                                                                          |             
      Pars Distalis, Angiectasis           |                                  2                                       |             
      Pars Distalis, Cyst                  |       X        X                          X                              |             
      Pars Distalis, Hyperplasia           |                                                    1     2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |       2           2                                                      |             
      Follicle, Ectasia                    |          2                          2                    2               |             
      Follicle, Hyperplasia                |                      2                                                   |             
      Follicular Cell, Ectasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|             
                                           | 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Abscess                              | 4                             4  4           4                           |             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |       3                                                                  |             
      Mineralization                       |                                                 3                        |             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                     X     X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Abscess                              |                      4                                                   |             
      Angiectasis                          |                                                 2                        |             
      Hydrometra                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  2     3  3  3  3  3  3  4        2  3  4  2  3  3  4  3               |             
      Endometrium, Inflammation, Acute     | 3              2              3  4           4                           |             
      Endometrium, Metaplasia, Squamous    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +                                                                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Angiectasis                          |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Myelofibrosis                        |       2  3  2           3                 1        2     2               |             
      Myeloid Cell, Hyperplasia            | 2  2  2     2  2     4     2  2  3  2  2     2     2  2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Iliac, Hyperplasia, Lymphoid         |                                                 3                        |             
      Mediastinal, Hyperplasia, Lymphoid   |             2              2              2                              |             
      Renal, Hyperplasia, Lymphoid         |                               3                                          |             
      Renal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +               |             
      Hyperplasia, Lymphoid                |    2     2  2  2     3  2  2  2        2  2     3  2  2  1               |             
      Pigmentation                         |          1  2     2     2              2           2  2  2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Angiectasis                          |                                        2                                 |             
      Congestion                           |          3                 3                                             |             
      Hyperplasia, Lymphoid                | 2  2     2  2  2        3  2              3  3  2  3  2                  |             
      Inflammation, Acute                  |                               2                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hematopoietic Cell Proliferation     | 2  3  2  2  2  2  2  4  2  2  3  3  2  3  2  4     2  1  2               |             
      Hyperplasia, Lymphoid                |          2              2  2              2        2  2                  |             
      Inflammation, Acute                  |                               3              3                           |             
      Pigmentation                         |    2  1  1  1  2  2        2              1     2  2  2  2               |             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +               |             
      Cyst                                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|             
                                           | 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |    3     3  2  2           2  2  2                                       |             
      Inflammation, Acute                  |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Acinus, Ectasia                      |                            2  2        3                 2               |             
      Duct, Ectasia                        |                                                 3                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Chronic                |                1           1        1                                    |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Multifocal             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mineralization                       | 2           2        1     2  2  2     2  2  2     1  2                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Abscess                              |                                              4                           |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                 2                        |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  2  2  2  2  2  1  1     2  2  1  2  2  2  2               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                    2     2               |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
          Active                           |                2                                                         |             
      Interstitium, Inflammation, Acute    |                                                                          |             
      Mediastinum, Atypia Cellular         |                                     X                                    |             
      Mediastinum, Inflammation, Acute     | 3                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Lumen, Hemorrhage                    |                   2  2  1  1              1                              |             
      Mucosa, Inflammation, Acute          |                1                                                         |             
      Nasolacrimal Duct, Hemorrhage        |       2  2                             2           1                     |             
      Olfactory Epithelium, Degeneration   |    2  2  2  2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2               |             
      Respiratory Epithelium, Degeneration | 2                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 9| 3| 5| 0| 2| 2| 2| 2| 2| 2| 5| 8| 0| 0| 3| 5| 8| 3| 3| 3| 5| 5| 5| 5| 5|             
                                           | 1| 7| 3| 6| 9| 9| 9| 9| 9| 9| 9| 6| 0| 8| 0| 7| 7| 0| 0| 0| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |    2  2  2  2  2        2  1  2  2  2     2     1  2  2  2               |             
      Inflammation, Acute                  |                                              4                           |             
      Inflammation, Chronic                |       4                                                                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |       3                                                                  |             
      Capsule, Inflammation, Chronic Active|                                                                          |             
      Renal Tubule, Casts Protein          |       3  2           2           2                                       |             
      Renal Tubule, Ectasia                |       3  2     1     2  1        2     1                 1               |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Necrosis               |       3        1                          1              1               |             
      Renal Tubule, Regeneration           |       2                                            1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2     2  2  2  2  2  2  2     2  2     2  2  2  2               |             
      Inflammation, Acute                  |                                              3                           |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 7| 7| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  M  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  M  +  +  +  +                                             |  46        |
      Infiltration Cellular, Lymphocyte    |    2              2  2     2                                             |     20  1.9|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Inflammation, Chronic Active         |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Serosa, Inflammation, Chronic Active |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +                                             |  47        |
      Serosa, Inflammation, Chronic Active |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Serosa, Inflammation, Chronic Active |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Fatty Change                         | 2                                                                        |      2  2.0|
      Focal Cellular Change                |                                                                          |      1     |
      Hematopoietic Cell Proliferation     | 2     2  2     2     1                                                   |     20  2.0|
      Infiltration Cellular, Lymphocyte    | 2  2  2     2           2  1                                             |     23  1.8|
      Inflammation, Acute                  |                                                                          |      3  2.0|
      Necrosis                             |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            |             2                                                            |      2  2.0|
      Hepatocyte, Hyperplasia              |                                                                          |      1  2.0|
      Serosa, Inflammation, Chronic        |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |  10        |
      Inflammation, Acute                  |                                                                          |      4  3.5|
      Inflammation, Chronic Active         |                4                                                         |      2  3.5|
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  M                                             |  47        |
      Abscess                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    | 1  2  2           2                                                      |     21  1.8|
      Inflammation, Chronic Active         |                4                                                         |      1  4.0|
      Acinus, Atrophy                      |                                                                          |      2  3.0|
      Duct, Ectasia                        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  46        |
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2     1  1  2  2                                             |     40  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 7| 7| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Squamous                | 2                                                                        |      4  2.3|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Inflammation, Chronic Active         | 2                                                                        |      2  2.5|
      Mineralization                       |                                                                          |      2  1.0|
      Ulcer                                | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    |             2  2  2                                                      |     15  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      3  2.0|
      Mucosa, Ectasia                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      9  1.6|
      Inflammation, Acute                  |                                                                          |      3  1.7|
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
      Ventricle, Thrombosis                |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Capsule, Inflammation, Chronic Active|                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Fatty                  | 3                          3                                             |      3  2.7|
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Acute                  |                3                                                         |      2  2.0|
      Pigmentation                         |    2  2  2  1     1  1  2  1                                             |     35  1.8|
      Spindle Cell, Hyperplasia            | 2  2  2  2  2  2  2  2  2  2                                             |     50  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |    2                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  M                                             |  47        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  +  +  M  M  M  M                                             |  26        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +                                             |  46        |
      Congestion                           |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 7| 7| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst                  |                                                                          |      4     |
      Pars Distalis, Hyperplasia           |    2           2                                                         |      8  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    | 2  2        2        1                                                   |      8  1.8|
      Follicle, Ectasia                    |                2  2                                                      |      8  2.1|
      Follicle, Hyperplasia                |                      2                                                   |      3  1.7|
      Follicular Cell, Ectasia             |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Abscess                              |                4                                                         |      9  4.0|
      Angiectasis                          |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Follicle, Cyst                       |                         X                                                |      3     |
      Periovarian Tissue, Cyst             |    X                       X                                             |      5     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      2  4.0|
      Angiectasis                          |                                                                          |      1  2.0|
      Hydrometra                           |       3                                                                  |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 3  4  3  3  2  3  3  3  2  3                                             |     44  3.0|
      Endometrium, Inflammation, Acute     |                                                                          |      9  3.2|
      Endometrium, Metaplasia, Squamous    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |          3                                                               |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                2                                                         |      1  2.0|
      Myelofibrosis                        |    1  3        2     2     2                                             |     21  2.3|
      Myeloid Cell, Hyperplasia            | 2        2        2     2                                                |     34  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      2  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      3  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  3.0|
      Renal, Inflammation, Acute           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 7| 7| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  46        |
      Hyperplasia, Lymphoid                | 2  2  2  2  3  2     3  2  2                                             |     39  2.1|
      Pigmentation                         | 2  2  2  2  2  2     2     2                                             |     24  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Congestion                           | 4                                                                        |      4  3.0|
      Hyperplasia, Lymphoid                |       2  2  2        2  2  2                                             |     24  2.3|
      Inflammation, Acute                  |                3                                                         |      4  2.5|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hematopoietic Cell Proliferation     | 2  2  2  2     4  3  2  3  2                                             |     46  2.4|
      Hyperplasia, Lymphoid                |    2  2     2        2     2                                             |     19  2.0|
      Inflammation, Acute                  |                                                                          |      4  3.0|
      Pigmentation                         | 2  1  2  2  2        2  2  2                                             |     28  1.8|
      Capsule, Inflammation, Chronic       |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Cyst                                 |    X                                                                     |      6     |
      Edema                                |                2                                                         |      1  2.0|
      Hyperplasia, Lymphoid                |          2  2        3     3                                             |     18  2.3|
      Inflammation, Acute                  |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Acinus, Ectasia                      |       2        2  1     2  1                                             |      9  1.9|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                | 2     2                 1  1                                             |     18  1.5|
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
      Inflammation, Multifocal             |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mineralization                       | 2  2  2  2     1  2     2  2                                             |     26  1.8|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 7| 7| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  4.0|
      Congestion                           |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      2  1.5|
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  2  2  1  2  2                                             |     48  1.9|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |          2                                                               |      4  2.0|
      Arteriole, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Interstitium, Inflammation, Acute    |                                                                          |      2  2.0|
      Mediastinum, Atypia Cellular         |                                                                          |      1     |
      Mediastinum, Inflammation, Acute     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Lumen, Hemorrhage                    |          1  2  1  2     2  1                                             |     20  1.6|
      Mucosa, Inflammation, Acute          |                                                                          |      1  1.0|
      Nasolacrimal Duct, Hemorrhage        |    2                                                                     |      7  1.9|
      Olfactory Epithelium, Degeneration   | 2  2  2  2  2  2  2  2  2  1                                             |     48  2.0|
      Respiratory Epithelium, Degeneration |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  3  2  2  2  2                                             |     43  2.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                4                                                         |      1  4.0|
      Metaplasia, Osseous                  |       3           3                                                      |      3  3.0|
      Capsule, Inflammation, Chronic Active|                2                                                         |      1  2.0|
      Renal Tubule, Casts Protein          | 1              1  1  1                                                   |     12  1.6|
      Renal Tubule, Ectasia                | 1        1     2  1  2                                                   |     20  1.5|
      Renal Tubule, Mineralization         |    1                                                                     |      2  1.5|
      Renal Tubule, Necrosis               | 1  2  1     1  3  1        1                                             |     16  1.4|
      Renal Tubule, Regeneration           |    2  1     1  3  2                                                      |     15  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  2  2     2                                                |     32  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 0| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 7| 7| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Serosa, Inflammation, Chronic Active |                3                                                         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|             
                                           | 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +                 +  M  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1        2                 2        1                                2   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +                 +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +                 +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  A  +  +  +|             
      Cytomegaly                           |                         3                                                |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  1  1     1     3              2  3  4                             1  2|             
      Infiltration Cellular, Lymphocyte    |    2     2  2           1  2     2  1     1                       2  2   |             
      Inflammation, Acute                  |                               2                                          |             
      Necrosis                             |                                                                          |             
      Serosa, Inflammation, Acute          |                   3                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +           +     +  +                             +  +|             
      Inflammation, Acute                  |                               3     3  4                                4|             
      Inflammation, Chronic Active         |                   3                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
      Infiltration Cellular, Lymphocyte    |          2              2  2              1                              |             
      Inflammation, Acute                  |                                                                         2|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                   4                                                      |             
      Duct, Cyst                           |                            X                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +                 +  M  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2  2     2  2  2  2     2  2        2  2  2                       2  2  2|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Squamous                | 2  2     3  3           2  2        2  2  2                    2  3      |             
      Infiltration Cellular, Lymphocyte    |                   2                                               2      |             
      Inflammation, Acute                  |          2              2                                         2      |             
      Inflammation, Chronic Active         | 2  2                       2        3  2                                 |             
      Inflammation, Subacute               |                                                                          |             
      Ulcer                                |          4              3  2           4                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |             2                          2                             2   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|             
                                           | 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Acute          |                                           2                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Embolus Bacterial                    |                                                                4         |             
      Infiltration Cellular, Lymphocyte    | 1                       2              1  1                              |             
      Inflammation, Acute                  |                               2                                3         |             
      Inflammation, Chronic                |                                                                          |             
      Epicardium, Inflammation, Acute      |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Capsule, Inflammation, Acute         |                                     3                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                   3                       2                              |             
      Degeneration, Fatty                  |                                                                          |             
      Inflammation, Acute                  |                   2                                                      |             
      Pigmentation                         | 2  2  2  2  1  1        2  2     2  1     2                          2  1|             
      Spindle Cell, Hyperplasia            | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2                 2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia                          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  +  M  M  M  +  +  +  M  +  M                 +  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
      Pars Distalis, Cyst                  |                                                                         X|             
      Pars Distalis, Hyperplasia           |    2  2  2                                                           3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
      Infiltration Cellular, Lymphocyte    |          2  1                                                           2|             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Ectasia                    |                                                                      2  2|             
      Follicle, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Abscess                              |                   4           4  4  4  4                                4|             
      Hemorrhage                           |                                                             4            |             
      Mineralization                       |                                                                          |             
      Follicle, Cyst                       |                            X                                         X   |             
      Periovarian Tissue, Cyst             |             X                                               X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|             
                                           | 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Angiectasis                          |                            2                                             |             
      Hydrometra                           |                                                                          |             
      Endometrium, Abscess                 |                                                                         4|             
      Endometrium, Hyperplasia, Cystic     | 2  4  3  4  3  2  2     2  4  2  2  2  3  3                 4  3     3  3|             
      Endometrium, Inflammation, Acute     |                         2     4  2  2  4                                 |             
      Endometrium, Metaplasia, Squamous    |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  | +                                                           +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Myelofibrosis                        |       1                 2  2                                         4   |             
      Myeloid Cell, Hyperplasia            | 2  2  2  2  2  2  2  2  2     2  2  4  3  2                             4|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |       2                       2                                         3|             
      Mediastinal, Inflammation, Acute     |                                        4                                 |             
      Renal, Hyperplasia, Lymphoid         |                                  3  3  3                                 |             
      Renal, Inflammation, Acute           |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +                 +  M  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                | 2  2  2  2  2  2  2     2  2     2  2  2  2                 2     2  2  2|             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         | 2     2     2  1        2  2        2                             2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
      Congestion                           |                                     2                                    |             
      Hyperplasia, Lymphoid                | 2  2  2  3     2  2        2  2  3  2  2  2                 2     2     2|             
      Inflammation, Acute                  |                                     3  2                                 |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
      Hematopoietic Cell Proliferation     | 4  2  2  2  4     4     3  2  2  3  4  4  2                 3           4|             
      Hyperplasia, Lymphoid                |    2  2  2              2  2              2                       2      |             
      Inflammation, Acute                  |                   3                 2  3                                 |             
      Pigmentation                         |    2  2  2     2        2  2              2                       2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  M  +  +|             
      Cyst                                 |                X                    X                                X   |             
      Hyperplasia, Lymphoid                |          2                 2        2                                    |             
      Inflammation, Acute                  |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M  M  +  +  +|             
      Acinus, Ectasia                      | 1  2           2  2                 2                                    |             
      Duct, Ectasia                        |                                  2                                      2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|             
                                           | 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |          2        2                    2                    2        2   |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cranium, Inflammation, Chronic       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Compression                          | X                                                                        |             
      Gliosis                              |                                                                      2   |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        | 3                                                                        |             
      Infiltration Cellular, Lymphocyte    |                                                                   2      |             
      Mineralization                       |       2     2  1        2           2  2                    2  2  2  2  2|             
      Meninges, Hemorrhage                 |                                                                          |             
      Meninges, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                                                   3      |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  2        2  2     2  2  2  2                 2  2  2  2  2|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Bronchiole, Inflammation, Acute      |                   2                                                      |             
      Interstitium, Inflammation, Acute    |                   2                 3  2                                 |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
      Mediastinum, Inflammation, Acute     |                               4                                          |             
      Peribronchial, Inflammation, Acute   |                               4                                          |             
      Pleura, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Lumen, Hemorrhage                    |    1        3                                                     2      |             
      Nasolacrimal Duct, Hemorrhage        | 2              2           2     1                                       |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Degeneration   | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2                 2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| 4| 6| 7| 7| 4| 4| 4| 4| 4| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 4| 7| 0| 3| 3| 3| 6| 2| 0| 3| 5| 5| 5| 5| 5| 6| 7| 8| 9| 3|             
                                           | 1| 0| 0| 0| 0| 8| 7| 2| 1| 1| 8| 9| 4| 2| 1| 8| 8| 8| 8| 8| 1| 8| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2     2  2     2  2     2     2  2                       2  2  2|             
      Inflammation, Acute                  |                                     3                                    |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Renal Tubule, Casts Protein          |    2  2     2                       2                             1      |             
      Renal Tubule, Ectasia                |    2  2     2                       3                             1      |             
      Renal Tubule, Necrosis               | 2     1                             2                                   1|             
      Renal Tubule, Regeneration           |          2                       1  2                                   2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2  2  2  2  2        2  2     2  2  2  2                       2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|             
                                           | 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2  2  2           2  2     2     2  2                             2|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  +  +  +  +  +  A  +  +  +  +  +  +  +  M                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  M                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cytomegaly                           |                                                                          |             
      Focal Cellular Change                |    X                                                                     |             
      Hematopoietic Cell Proliferation     |    2  2           3  1     1     1                                      2|             
      Infiltration Cellular, Lymphocyte    |          1  1           2  2     2     1  2                       2  1   |             
      Inflammation, Acute                  |                2                                               3         |             
      Necrosis                             |                2              3                                          |             
      Serosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +           +              +                             +            |             
      Inflammation, Acute                  | 3  3           3                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |             2           2  1     2        2                          1   |             
      Inflammation, Acute                  | 2                                                                        |             
      Inflammation, Chronic                |                                           3                              |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Cyst                           |                                     X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2  2  2     2  2  2  2     2  2     2                       2  2  2|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Squamous                | 2  2        3        2        2  1     2                             3  2|             
      Infiltration Cellular, Lymphocyte    |       2                          2                                      2|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 2                    2                                               2   |             
      Inflammation, Subacute               |    1                                                                     |             
      Ulcer                                |                      3                                               4   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +                    +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2  2  2           2        2                                2     2|             
      Inflammation, Acute                  |                                                                         2|             
      Inflammation, Chronic Active         |                                           2                       2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|             
                                           | 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Embolus Bacterial                    |                                                                          |             
      Infiltration Cellular, Lymphocyte    |          1           1                                                   |             
      Inflammation, Acute                  | 2                                                                        |             
      Inflammation, Chronic                |                                                             2            |             
      Epicardium, Inflammation, Acute      |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Capsule, Inflammation, Acute         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Degeneration, Fatty                  |                         3                                                |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |       2  2           1  2  2     2  2     2                       2  2  2|             
      Spindle Cell, Hyperplasia            | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2                 2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia                          |                                           1                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Chronic                |                                           3                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  +  +  M  M  +  M  +  +  +  +                 +  M  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |          2           2        2     2                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                             2            |             
      Follicle, Ectasia                    |                                        3                       2         |             
      Follicle, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Abscess                              | 4  4           4  4           4                                4         |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                               2                                          |             
      Follicle, Cyst                       |       X                                                                  |             
      Periovarian Tissue, Cyst             |                   X                 X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|             
                                           | 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Abscess                              |                4                                                         |             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |                                                                          |             
      Endometrium, Abscess                 |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  2  2  3  2  3  3  3  3  4     2  3  4  3                 3     2  3  3|             
      Endometrium, Inflammation, Acute     | 2  3  2              3  2                 2                       2     3|             
      Endometrium, Metaplasia, Squamous    |                      2                                                   |             
                                            __________________________________________________________________________|             
   Vagina                                  | +  +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Myelofibrosis                        |          2           2  2           2                                    |             
      Myeloid Cell, Hyperplasia            | 2  3  2  2     2     2  2  2  2        2  2                    2  2  2  3|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   | 2                                                                        |             
      Mediastinal, Inflammation, Acute     |                                                                4         |             
      Renal, Hyperplasia, Lymphoid         |    3                                                                     |             
      Renal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                                                2         |             
      Hyperplasia, Lymphoid                |    2  2  2  2     2  2  2        2  3     2                 2     2  2  2|             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |    2  2  2           2     2     2  3     2                          2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  A  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |    2  2  2     2        2  2     3        2                 2        1  3|             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4  3  2  2  1  2  3  2  3  2  2  2  2  2  2                 3  2  2  2  4|             
      Hyperplasia, Lymphoid                |          2              2        3                                       |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |       1  2  1        2     1     2  2  2  1                       2  2  1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cyst                                 |    X                             X  X                                   X|             
      Hyperplasia, Lymphoid                |       2              2  2                 2                       2     2|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Acinus, Ectasia                      |       1  2                                2                          2   |             
      Duct, Ectasia                        | 2  2                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|             
                                           | 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |          1                 1  2                                   2  2  1|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cranium, Inflammation, Chronic       |          3                                                               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Compression                          |                                                                          |             
      Gliosis                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Mineralization                       |    2     2  2     2  1  2  2     2     1                             2  2|             
      Meninges, Hemorrhage                 |    2                                                                     |             
      Meninges, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |             2     3                                                      |             
      Hemorrhage                           |       2                    1                                         2   |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  1  2  2  2  2     2  2     2                 2     2  2  2|             
      Alveolar Epithelium, Hyperplasia     |                                  2                                       |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       4                    1                                             |             
      Bronchiole, Inflammation, Acute      |                                                                          |             
      Interstitium, Inflammation, Acute    |                                                                2         |             
      Interstitium, Inflammation, Chronic  |                                                                         3|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
      Mediastinum, Inflammation, Acute     | 2                                                                        |             
      Peribronchial, Inflammation, Acute   |                                                                          |             
      Pleura, Inflammation, Acute          |                1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Lumen, Hemorrhage                    |       2  2                 2     1                          2           2|             
      Nasolacrimal Duct, Hemorrhage        |                      2  2           2  1  1                              |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                               1                                          |             
      Olfactory Epithelium, Degeneration   | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2                 2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 7| 3| 3| 3| 4| 1| 3| 3| 3| 9| 1| 3| 3| 3| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3|             
                                           | 4| 7| 1| 1| 1| 2| 7| 1| 1| 1| 3| 7| 1| 1| 1| 8| 8| 8| 8| 8| 7| 7| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  2  2  2  2  2     2  2     2                    2  2  2  2|             
      Inflammation, Acute                  | 4                                                                        |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                         1                                                |             
      Renal Tubule, Casts Protein          |    2     1           1                                      2            |             
      Renal Tubule, Ectasia                |    2     1                 1     2     1                    2            |             
      Renal Tubule, Necrosis               |    2  1     1                                               2     1      |             
      Renal Tubule, Regeneration           |       2     1        1     2     1                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2  2  2     2  2  2  2  2        2  2                             2     2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3|                                            |            |
                                           | 9| 4| 9| 4| 4| 7| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Infiltration Cellular, Lymphocyte    |                   2  2  2                                                |     17  1.9|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Cytomegaly                           |                                                                          |      1  3.0|
      Focal Cellular Change                |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |    2     2  1     2                                                      |     21  1.9|
      Infiltration Cellular, Lymphocyte    |       2           2  2  2                                                |     23  1.7|
      Inflammation, Acute                  |                2           1                                             |      5  2.0|
      Necrosis                             |                                                                          |      2  2.5|
      Serosa, Inflammation, Acute          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +                                                                     |  13        |
      Inflammation, Acute                  |    3                                                                     |      8  3.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  +  +  +  +  +                                             |  48        |
      Infiltration Cellular, Lymphocyte    |          2     3  2     2  2                                             |     15  1.9|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Duct, Cyst                           |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | M  M  +  +  +  +  +  +  +  +                                             |  46        |
      Infiltration Cellular, Lymphocyte    |       2  2        2        2                                             |     31  2.0|
      Acinus, Atrophy                      |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Erosion                              |                      2                                                   |      1  2.0|
      Hyperplasia, Squamous                |       1     3  2  4  2  2                                                |     26  2.2|
      Infiltration Cellular, Lymphocyte    |             2                                                            |      6  2.0|
      Inflammation, Acute                  |                                                                          |      3  2.0|
      Inflammation, Chronic Active         |       2        4  3  1  1                                                |     13  2.2|
      Inflammation, Subacute               |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3|                                            |            |
                                           | 9| 4| 9| 4| 4| 7| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                   1                                                      |      7  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Infiltration Cellular, Lymphocyte    |                2  2     2                                                |     13  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
      Mucosa, Inflammation, Acute          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Embolus Bacterial                    |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |    2     1                                                               |      8  1.3|
      Inflammation, Acute                  |                                                                          |      3  2.3|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Epicardium, Inflammation, Acute      |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Capsule, Inflammation, Acute         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      2  2.5|
      Degeneration, Fatty                  |          2           2     3                                             |      4  2.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Pigmentation                         |       2  2  1  2  2  2  2  2                                             |     32  1.8|
      Spindle Cell, Hyperplasia            |    2  2  2  2  2  2  2  2  2                                             |     49  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +                                             |  48        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  M  +  M  M  +  +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +                                             |  48        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                                          |      8  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  M  +  +  +  +  +  M  +  +                                             |  46        |
      Infiltration Cellular, Lymphocyte    |          1  2                                                            |      5  1.6|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Follicle, Ectasia                    |          2                                                               |      5  2.2|
      Follicle, Hyperplasia                |          1                 3                                             |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3|                                            |            |
                                           | 9| 4| 9| 4| 4| 7| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Abscess                              |    4     4     4  4                                                      |     16  4.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                                                          |      3     |
      Periovarian Tissue, Cyst             |       X     X     X  X                                                   |      8     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  4.0|
      Angiectasis                          |                                                                          |      1  2.0|
      Hydrometra                           |       3                                                                  |      1  3.0|
      Endometrium, Abscess                 |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |    2  3  2  4  3  2  3  3  3                                             |     45  2.8|
      Endometrium, Inflammation, Acute     |    3     2        2     1                                                |     17  2.4|
      Endometrium, Metaplasia, Squamous    |                2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |    +                                                                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Myelofibrosis                        |       2  1  1        2  1                                                |     13  1.8|
      Myeloid Cell, Hyperplasia            |    2     3  2  3  2  2  2  2                                             |     38  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Mediastinal, Hyperplasia, Lymphoid   |          2     2                                                         |      6  2.2|
      Mediastinal, Inflammation, Acute     |                                                                          |      2  4.0|
      Renal, Hyperplasia, Lymphoid         |    2     4                                                               |      6  3.0|
      Renal, Inflammation, Acute           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  +  +  +  +  +  +                                             |  46        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |       2  2  2  2  3  2  2  2                                             |     39  2.1|
      Inflammation, Acute                  |                   3                                                      |      1  3.0|
      Pigmentation                         |       2  2  2           2                                                |     22  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |       2  2  2  3  2        2                                             |     32  2.1|
      Inflammation, Acute                  |    3                                                                     |      3  2.7|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hematopoietic Cell Proliferation     |    3  3  3  2  4  3  3  2  2                                             |     44  2.7|
      Hyperplasia, Lymphoid                |                      2                                                   |     11  2.1|
      Inflammation, Acute                  |                                                                          |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3|                                            |            |
                                           | 9| 4| 9| 4| 4| 7| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         |       2     2  1  1     2  1                                             |     26  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Cyst                                 |                                                                          |      7     |
      Hyperplasia, Lymphoid                |                2  3     2                                                |     12  2.1|
      Inflammation, Acute                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Acinus, Ectasia                      |       2  2     2     2                                                   |     13  1.8|
      Duct, Ectasia                        |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |          2     2     2  1                                                |     15  1.7|
      Inflammation, Chronic Active         |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cranium, Inflammation, Chronic       |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Compression                          |                                                                          |      1     |
      Gliosis                              |                                                                          |      1  2.0|
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Mineralization                       |          2  2  2  2        2                                             |     27  1.9|
      Meninges, Hemorrhage                 |                                                                          |      1  2.0|
      Meninges, Inflammation, Chronic      |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |    2                                                                     |      4  2.5|
      Hemorrhage                           |                                                                          |      3  1.7|
      Infiltration Cellular, Lymphocyte    |    2  2  2  2  2  2     2  2                                             |     42  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 2| 3| 3| 8| 3| 3| 3| 3|                                            |            |
                                           | 9| 4| 9| 4| 4| 7| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Bronchiole, Inflammation, Acute      |                                                                          |      1  2.0|
      Interstitium, Inflammation, Acute    |                2                                                         |      5  2.2|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  3.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |          2                                                               |      1  2.0|
      Mediastinum, Inflammation, Acute     |    2                                                                     |      3  2.7|
      Peribronchial, Inflammation, Acute   |                                                                          |      1  4.0|
      Pleura, Inflammation, Acute          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lumen, Hemorrhage                    |          1  2     2     1                                                |     13  1.8|
      Nasolacrimal Duct, Hemorrhage        |                      1     2                                             |     11  1.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
      Olfactory Epithelium, Degeneration   | 2     2  2  2  2  2  2  2  2                                             |     49  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | M  M  +  +  +  +  +  +  +  +                                             |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |    2  2  2  2  2  2  2  2  2                                             |     40  2.0|
      Inflammation, Acute                  |                                                                          |      2  3.5|
      Metaplasia, Osseous                  |                            2                                             |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Renal Tubule, Casts Protein          |                   2        1                                             |     11  1.6|
      Renal Tubule, Ectasia                |                1  2  2     1                                             |     15  1.7|
      Renal Tubule, Necrosis               |          1                 2                                             |     11  1.5|
      Renal Tubule, Regeneration           |          2                 1                                             |     11  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Infiltration Cellular, Lymphocyte    |    2  2  2  2  2  2  2  2  2                                             |     35  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 3| 3| 3| 8| 5| 0| 3| 3| 5| 5| 5| 5| 5| 9| 2| 3| 3| 3| 5| 8| 3| 3| 3|             
                                           | 0| 2| 4| 4| 4| 5| 1| 3| 4| 4| 8| 8| 8| 8| 8| 9| 3| 4| 4| 4| 8| 8| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +           +  +  +                       +  +           +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +           +  +  +                       +  +           +  M         |             
      Infiltration Cellular, Lymphocyte    |    2                                         2                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +           +  +  +                       +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +           +  +  +                       +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +           +  +  +                       +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +           +  +  +                       +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +           +  +  +                       +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +           +  +  +                       +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +           +  +  +                       +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +           +  +  +                       +  +           A  +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +           +  +  +     +                 +  +  +        +  +         |             
      Hematopoietic Cell Proliferation     | 1  2                                                                     |             
      Infiltration Cellular, Lymphocyte    |                      2                                                   |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                3                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                                             3            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +           +  +  +                       +  +           A  +  +      |             
      Infiltration Cellular, Lymphocyte    |                   1                                                      |             
      Inflammation, Chronic Active         |                      3                                                   |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +           +  +  +                       M  +           M  +         |             
      Infiltration Cellular, Lymphocyte    | 2  2              2  2                                         2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Erosion                              |                                                                          |             
      Hyperplasia, Squamous                |                2  2  2                                                   |             
      Inflammation, Acute                  |                   2  2                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  A  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                         2|             
      Mineralization                       |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +           +  +  +                       +  +           +  +         |             
      Infiltration Cellular, Lymphocyte    |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +           +  +  +                       +  +           +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +           +  +  +                       +  +           +  +         |             
      Pigmentation                         |    1              1                             2                        |             
      Spindle Cell, Hyperplasia            | 2  2           1  2  2                       2  2           2  2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 3| 3| 3| 8| 5| 0| 3| 3| 5| 5| 5| 5| 5| 9| 2| 3| 3| 3| 5| 8| 3| 3| 3|             
                                           | 0| 2| 4| 4| 4| 5| 1| 3| 4| 4| 8| 8| 8| 8| 8| 9| 3| 4| 4| 4| 8| 8| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +           +  +  +                       +  +           +  +         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +           +  +  +                       +  +           A  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M           M  M  +                       M  +           M  M         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +           +  +  +                       +  M           M  +        +|             
      Pars Distalis, Angiectasis           | 2                                                                        |             
      Pars Distalis, Hyperplasia           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +           +  +  +                       M  +           M  +         |             
      Follicle, Ectasia                    |                                                                          |             
      Follicle, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +        +  +  +  +     +                 +  +     +  +  +  +  +      |             
      Abscess                              | 4  4                 4                          4           4            |             
      Follicle, Cyst                       |                            2                                             |             
      Periovarian Tissue, Cyst             |             2     2                                   2  2     2  2      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +                    +  +  +  +     +  +  +  +   |             
      Abscess                              | 3  4                                                                     |             
      Hydrometra                           |                                                                          |             
      Endometrium, Angiectasis             |                                                 2                        |             
      Endometrium, Hyperplasia, Cystic     | 2     2  2        3  2  3                    2  2  3  2     2  2  4  3   |             
      Endometrium, Inflammation, Acute     |                      2                                               2   |             
      Endometrium, Metaplasia, Squamous    |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  | +                                            +  +                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +           +  +  +                       +  +           +  +         |             
      Myelofibrosis                        |                   2                                                      |             
      Myeloid Cell, Hyperplasia            | 2  2              2  2                          3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +  +  +                       +  +           A  +         |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   | 2  2              2                                                      |             
      Mediastinal, Inflammation, Acute     |                      4                                                   |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         | 3                    3                                                   |             
      Renal, Inflammation, Acute           |    4                 3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +           +  +  +                       M  +           M  +         |             
      Hyperplasia, Lymphoid                | 2  2              2  2                                                   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +           +  +  +                       +  +           A  +         |             
      Congestion                           |                      3                                                   |             
      Hyperplasia, Lymphoid                | 2  2                 3                       2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 3| 3| 3| 8| 5| 0| 3| 3| 5| 5| 5| 5| 5| 9| 2| 3| 3| 3| 5| 8| 3| 3| 3|             
                                           | 0| 2| 4| 4| 4| 5| 1| 3| 4| 4| 8| 8| 8| 8| 8| 9| 3| 4| 4| 4| 8| 8| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +           +  +  +     +                 +  +           A  +     +   |             
      Hematopoietic Cell Proliferation     | 3  4              2  3     2                    3              2     3   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |                                                                          |             
      Capsule, Inflammation, Chronic       |                      3                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +           +  +  +                       M  +           +  +         |             
      Hyperplasia, Lymphoid                |                   2  2                                         2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +        +  +  +  +                       +  +           M  +         |             
      Acinus, Ectasia                      |                                                                          |             
      Duct, Ectasia                        | 2                 2                             1                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +     +                 +  +     +     +  +  +  +  +|             
      Inflammation, Chronic                |    2                       2                 2                    2      |             
      Head, Ulcer                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +           +  +  +                       +  +           +  +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +           +  +  +                       +  +           +  +         |             
      Hydrocephalus                        |                                                                          |             
      Mineralization                       | 1  2           2  1  1                                         1         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +           +  +  +                       +  +           +  +         |             
      Congestion                           |                                                 2                        |             
      Hemorrhage                           |    2                                                                     |             
      Infiltration Cellular, Lymphocyte    | 2  2              2  2                       2  2           2  1         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                   2                                                      |             
      Interstitium, Inflammation, Acute    | 3                                                              2         |             
      Mediastinum, Inflammation, Acute     |                                                 3                        |             
      Peribronchial, Inflammation, Acute   |                                                                          |             
      Pleura, Inflammation, Acute          |                                                             3            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +           +  +  +                       +  +           +  +         |             
      Lumen, Hemorrhage                    |                   2                                                      |             
      Nasolacrimal Duct, Hemorrhage        |    2                                                                     |             
      Olfactory Epithelium, Degeneration   | 2  2           2  2  2                       2  1           2  2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +           +  +  +                       +  +           +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 4| 4| 4| 4| 5| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 7| 3| 3| 3| 8| 5| 0| 3| 3| 5| 5| 5| 5| 5| 9| 2| 3| 3| 3| 5| 8| 3| 3| 3|             
                                           | 0| 2| 4| 4| 4| 5| 1| 3| 4| 4| 8| 8| 8| 8| 8| 9| 3| 4| 4| 4| 8| 8| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +           +  +  +                       +  +           +  +         |             
      Amyloid Deposition                   |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1                 2  2                       2  2              2         |             
      Inflammation, Acute                  |    4                                                                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Renal Tubule, Casts Protein          |                   2                                                      |             
      Renal Tubule, Ectasia                |                   2                             1                        |             
      Renal Tubule, Mineralization         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +           +  +  +                       +  +           +  M         |             
      Infiltration Cellular, Lymphocyte    |                   2  2                       2  2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 9| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 9| 0| 3| 3| 3|             
                                           | 4| 8| 4| 4| 4| 7| 7| 5| 5| 5| 7| 8| 5| 5| 5| 8| 8| 5| 5| 5| 2| 6| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +           +  +           +  +           +  +           +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +           M  +           +  +           M  +           +  +         |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | M  +           +  +           +  +           +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  +           +  +           +  +           +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | M  +           +  +           +  +           +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +           +  +           M  +           +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | M  +  +        +  +           +  +           +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +           +  +           +  +           +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +           +  +           +  +           +  +           A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | M  +  +        +  +           +  +           +  +           A  +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +           +  +           +  +           +  +  +        +  +         |             
      Hematopoietic Cell Proliferation     |                   2                          2                           |             
      Infiltration Cellular, Lymphocyte    |    1                             2              1                        |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +           +                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                   3                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +           +  +           +  +           +  +        +  A  +         |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                  1                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M  +           +  +           +  +           +  +           +  +         |             
      Infiltration Cellular, Lymphocyte    |    2              2              2              2              2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                               X                                          |             
      Erosion                              |                                                       2                  |             
      Hyperplasia, Squamous                |    2  2                                               1        1  2      |             
      Inflammation, Acute                  |                2                                      2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |          2                                      2     2  2              2|             
      Mineralization                       |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +           +  +           +  +           +  +           +  +         |             
      Infiltration Cellular, Lymphocyte    |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +           +  +           +  +           +  +           +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +           +  +           +  +           +  +           +  +         |             
      Pigmentation                         |    1                             2                                       |             
      Spindle Cell, Hyperplasia            | 2  2           2  2           2  2           2  2           2  2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 9| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 9| 0| 3| 3| 3|             
                                           | 4| 8| 4| 4| 4| 7| 7| 5| 5| 5| 7| 8| 5| 5| 5| 8| 8| 5| 5| 5| 2| 6| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +           +  +           +  +           +  +           +  +         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +           +  +           +  +           +  +        +  A  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +           +  +           M  M           M  M           +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +           +  +           +  +           +  +           +  +         |             
      Pars Distalis, Angiectasis           |                                  2                                       |             
      Pars Distalis, Hyperplasia           |                   2                                            2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +           +  +           +  +           +  +           +  +         |             
      Follicle, Ectasia                    |                   2                                                      |             
      Follicle, Hyperplasia                |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +           +  +  +  +     +  +     +  +  +  +     +   |             
      Abscess                              |       4     4     4                 4        4                       4   |             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                        2                 2  X        2   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Hydrometra                           |                                        3                                 |             
      Endometrium, Angiectasis             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 1  3                 3  2  4  3  2  4     4  2  3  3  3  3  2  3  3  3  3|             
      Endometrium, Inflammation, Acute     |                   4                          2     2     3     4     2  2|             
      Endometrium, Metaplasia, Squamous    |                                                          2               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +           +  +           +  +           +  +           +  +         |             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |    2           2  2              2           2  2              3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +  +  +           +  +  +     +  +  +  +     +  +  +         |             
      Iliac, Hyperplasia, Lymphoid         |                                              3                           |             
      Mediastinal, Hyperplasia, Lymphoid   |                                              2                           |             
      Mediastinal, Inflammation, Acute     |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                          2               |             
      Renal, Hyperplasia, Lymphoid         |                   3                          3                           |             
      Renal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +           M  +           +  +           +  +           M  +         |             
      Hyperplasia, Lymphoid                |                   2                          2  2                        |             
      Pigmentation                         |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +           +  +           +  +  +     +  +  +  +        +  +         |             
      Congestion                           |                                     2                                    |             
      Hyperplasia, Lymphoid                |                   2                 2        2  2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 9| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 9| 0| 3| 3| 3|             
                                           | 4| 8| 4| 4| 4| 7| 7| 5| 5| 5| 7| 8| 5| 5| 5| 8| 8| 5| 5| 5| 2| 6| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | M  +  +     +  +  +           +  +  +        +  +           +  +         |             
      Hematopoietic Cell Proliferation     |       3     3  2              3  2  3        3                           |             
      Hyperplasia, Lymphoid                |       2                          2  2           2                        |             
      Inflammation, Acute                  |                   4                                                      |             
      Pigmentation                         |    2           2                                2                        |             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +           +  +           +  +           +  +           +  +         |             
      Hyperplasia, Lymphoid                |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +           M  +           +  +           +  +           M  +         |             
      Acinus, Ectasia                      |                                                                1         |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +|             
      Inflammation, Chronic                |                                                                   2      |             
      Head, Ulcer                          |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +           +  +           +  +           +  +           +  +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +           +  +           +  +           +  +           +  +         |             
      Hydrocephalus                        |                                                                          |             
      Mineralization                       |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +           +  +           +  +           +  +           +  +         |             
      Congestion                           | 4                                               2                        |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2              2           2  2           2  2           2            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                               2                                          |             
      Interstitium, Inflammation, Acute    |                                                                          |             
      Mediastinum, Inflammation, Acute     |                                                                          |             
      Peribronchial, Inflammation, Acute   |                                                                          |             
      Pleura, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +           +  +           +  +           +  +           +  +         |             
      Lumen, Hemorrhage                    |                2                 2                             2         |             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Olfactory Epithelium, Degeneration   |    2           2  2           2  2           2  2              2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +           +  +           +  +           +  +           +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 7| 7| 2| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 9| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 9| 0| 3| 3| 3|             
                                           | 4| 8| 4| 4| 4| 7| 7| 5| 5| 5| 7| 8| 5| 5| 5| 8| 8| 5| 5| 5| 2| 6| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +  +  +           +  +           +  +           +  +         |             
      Amyloid Deposition                   | 4                                                                        |             
      Infiltration Cellular, Lymphocyte    |    2              2           2  2           2  2                        |             
      Inflammation, Acute                  |                4                                                         |             
      Inflammation, Chronic Active         |             3                                                            |             
      Renal Tubule, Casts Protein          |                                                                          |             
      Renal Tubule, Ectasia                |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +           +  M           +  +           +  +           M  +         |             
      Infiltration Cellular, Lymphocyte    |    2                          2              2  2              2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 0| 3| 3|                                            |            |
                                           | 8| 8| 8| 8| 8| 7| 9| 7| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +  +                                                   |  22        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +  +  +                                                   |  18        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                M  +  +                                                   |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                M  +  +                                                   |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                M  +  +                                                   |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                M  +  +                                                   |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +  +  +                                                   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +  +  +                                                   |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                M  +  +                                                   |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                M  +  +                                                   |  19        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +  +  +                                                   |  25        |
      Hematopoietic Cell Proliferation     |                   2  2                                                   |      6  1.8|
      Infiltration Cellular, Lymphocyte    |                                                                          |      4  1.5|
      Inflammation, Acute                  |                2                                                         |      1  2.0|
      Necrosis                             |                   3                                                      |      3  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +  +                                                      |   5        |
      Cyst                                 |                   X                                                      |      1     |
      Inflammation, Acute                  |                3                                                         |      3  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +  +                                                   |  22        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                M  +  +                                                   |  18        |
      Infiltration Cellular, Lymphocyte    |                   2  2                                                   |     12  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +  +  +  +                                             |  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |      8  1.8|
      Inflammation, Acute                  |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    |                   2     2  2                                             |      9  2.0|
      Mineralization                       |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +  +                                                   |  22        |
      Infiltration Cellular, Lymphocyte    |                      2                                                   |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 0| 3| 3|                                            |            |
                                           | 8| 8| 8| 8| 8| 7| 9| 7| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +  +  +                                                   |  22        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +  +  +                                                   |  22        |
      Pigmentation                         |                                                                          |      5  1.4|
      Spindle Cell, Hyperplasia            |                2  2  2                                                   |     22  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +  +  +                                                   |  22        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +  +                                                   |  21        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                M  M  M                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                M  +  +     +                                             |  20        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                M  +  +                                                   |  19        |
      Follicle, Ectasia                    |                      2                                                   |      2  2.0|
      Follicle, Hyperplasia                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +  +  +  +  +                                             |  36        |
      Abscess                              |                4     4                                                   |     13  4.0|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Periovarian Tissue, Cyst             |                   2     2  2                                             |     13  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                +  +  +  +                                                |  42        |
      Abscess                              |                4                                                         |      3  3.7|
      Hydrometra                           |                                                                          |      1  3.0|
      Endometrium, Angiectasis             |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                2  3  3  2                                                |     37  2.6|
      Endometrium, Inflammation, Acute     |                      4                                                   |     10  2.7|
      Endometrium, Metaplasia, Squamous    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +  +                                                   |  22        |
      Myelofibrosis                        |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                   2  2                                                   |     14  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +  +                                                   |  26        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                      2                                                   |      5  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 0| 3| 3|                                            |            |
                                           | 8| 8| 8| 8| 8| 7| 9| 7| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Inflammation, Acute     |                                                                          |      1  4.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                3     3                                                   |      6  3.0|
      Renal, Inflammation, Acute           |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                M  +  +                                                   |  16        |
      Hyperplasia, Lymphoid                |                   2  2                                                   |      9  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                M  +  +                                                   |  23        |
      Congestion                           |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                      3                                                   |      9  2.2|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +  +  +                                                   |  25        |
      Hematopoietic Cell Proliferation     |                2  2  3                                                   |     18  2.7|
      Hyperplasia, Lymphoid                |                      2                                                   |      5  2.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Pigmentation                         |                   2                                                      |      4  2.0|
      Capsule, Inflammation, Chronic       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                M  +  +                                                   |  20        |
      Hyperplasia, Lymphoid                |                   2  2                                                   |      6  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +  +  +                                                   |  19        |
      Acinus, Ectasia                      |                                                                          |      1  1.0|
      Duct, Ectasia                        |                   2  2                                                   |      5  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +                                                   |  38        |
      Inflammation, Chronic                |                      2                                                   |      6  2.0|
      Head, Ulcer                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +                                                   |  22        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +  +                                                   |  22        |
      Hydrocephalus                        |                3                                                         |      1  3.0|
      Mineralization                       |                   2  2                                                   |      9  1.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +  +                                                   |  22        |
      Congestion                           |                3                                                         |      4  2.8|
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 0| 3| 3|                                            |            |
                                           | 8| 8| 8| 8| 8| 7| 9| 7| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Lymphocyte    |                2  2  2                                                   |     18  1.9|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.0|
      Interstitium, Inflammation, Acute    |                                                                          |      2  2.5|
      Mediastinum, Inflammation, Acute     |                                                                          |      1  3.0|
      Peribronchial, Inflammation, Acute   |                2                                                         |      1  2.0|
      Pleura, Inflammation, Acute          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +  +                                                   |  22        |
      Lumen, Hemorrhage                    |                      2                                                   |      5  2.0|
      Nasolacrimal Duct, Hemorrhage        |                                                                          |      1  2.0|
      Olfactory Epithelium, Degeneration   |                   2  2                                                   |     19  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                M  +  +                                                   |  21        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +  +  +                                                   |  23        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                   2  2                                                   |     14  1.9|
      Inflammation, Acute                  |                                                                          |      2  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Renal Tubule, Casts Protein          |                                                                          |      1  2.0|
      Renal Tubule, Ectasia                |                                                                          |      2  1.5|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                M  +  +                                                   |  18        |
      Infiltration Cellular, Lymphocyte    |                   2  2                                                   |     11  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|             
                             DAY ON TEST   | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|             
                                           | 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    | 2           2     2                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +               |             
      Inflammation, Acute                  |                3                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cytomegaly                           |                                                                          |             
      Fatty Change                         |                                        2                                 |             
      Focal Cellular Change                |                                                          X               |             
      Hematopoietic Cell Proliferation     | 2                             1                                          |             
      Infiltration Cellular, Lymphocyte    |          1     2           2              1     2                        |             
      Necrosis                             | 2              4                                                         |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Portal, Inflammation, Chronic        |                3                          2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
      Fat, Necrosis                        |    3                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular                | 2                                                                        |             
      Infiltration Cellular, Lymphocyte    |                                                 2                        |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    | 2  2     2  2  2  2     2  2        2  2  2     2  2  2  2               |             
      Acinus, Atrophy                      |                                           3                              |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia, Squamous                |                   2                       3                              |             
      Infiltration Cellular, Lymphocyte    |                   1                             2                        |             
      Mineralization                       |          2                                                               |             
      Ulcer                                |                                           2                              |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |                            2  2     2  2  2                              |             
      Inflammation, Acute                  |                                                 3                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |          2                 2                                             |             
      Mucosa, Ectasia                      |                                                                          |             
      Mucosa, Erosion                      |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|             
                             DAY ON TEST   | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|             
                                           | 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                                                                        |             
      Pulp, Inflammation, Chronic Active   | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    | 2                                                        1               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cyst                                 |                                                                          |             
      Hypertrophy                          |          2                                                               |             
      Spindle Cell, Hyperplasia            | 2  2  2  1  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia                          |             2                             2                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  M  M  M  +  M  M  M  +  M  M  +  M               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Pars Distalis, Hyperplasia           |                                                          2               |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |             2                                                            |             
      Ultimobranchial Cyst                 |                                     X                                    |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Ectasia                    |                                                                          |             
      Follicle, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    | 2                             2           2                              |             
                                            __________________________________________________________________________|             
   Penis                                   |                      +                                                   |             
      Inflammation, Acute                  |                      4                                                   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +              +     +                 +     +     +               |             
      Abscess                              |                                              4           4               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |       3                    4                       3                     |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Ectasia                              |    2                                                                     |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|             
                             DAY ON TEST   | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|             
                                           | 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Ectasia                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 2           2                                                            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mineralization                       |                                                          2               |             
      Interstitial Cell, Hyperplasia       |          2     2  2           2                       2                  |             
      Seminiferous Tubule, Mineralization  |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Atypia Cellular                      |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Myelofibrosis                        |          2                                      2                        |             
      Myeloid Cell, Hyperplasia            | 2  2  2  2  2  2  2     2     2     2           2     2  2               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inguinal, Hyperplasia, Lymphoid      |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia, Lymphoid                | 2  2  2     2  2  2     2  2  2  2     2  2     2  1     2               |             
      Pigmentation                         |    2           2        2  2              2              2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                4  2                    3                                 |             
      Hemorrhage                           |                                                    3                     |             
      Hyperplasia, Lymphoid                | 2        2  3     3           2     2  3  2     2  2  2  2               |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |    2  3                    2        3                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  3  4  2     2     4  4  4     2  4  2  3              2               |             
      Hyperplasia, Lymphoid                |             2     2                             2        2               |             
      Pigmentation                         |          1                                         1     2               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cyst                                 |       X  X  X  X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Erosion                              |          2                                                               |             
      Inflammation, Chronic                |       3  3  3  2     1     3           2        2  2  3                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Ulcer                                |                4     4                                                   |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|             
                             DAY ON TEST   | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|             
                                           | 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mineralization                       |          2  2  2  2  2  2  2  2  1  2  2  2     2  2  2  2               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                              3     2                     |             
      Hemorrhage                           |                   1                                   2                  |             
      Infiltration Cellular, Lymphocyte    | 2        2  2  2  2  2  2  2  2     2  2  2     2     2  2               |             
      Infiltration Cellular, Histiocyte    |                                                          2               |             
      Alveolar Epithelium, Hyperplasia     |    2                                            3                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                2                    2           2                        |             
      Alveolus, Inflammation, Acute        |                                                                          |             
      Bronchiole, Inflammation, Acute      |          1  1                                                            |             
      Bronchiole, Inflammation, Chronic    |                                                                          |             
          Active                           |                                     2                                    |             
      Interstitium, Inflammation, Acute    |                         2                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Lumen, Hemorrhage                    | 2  3        2     2        2  2     2  2                                 |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Nasolacrimal Duct, Hemorrhage        |                2                                                         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                        2                                 |             
      Olfactory Epithelium, Degeneration   |       2     2        2  2                       2  2                     |             
      Respiratory Epithelium, Degeneration |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  2  2     2  2  2     2  2  2     2  2  2  3               |             
      Metaplasia, Osseous                  |                                                                          |             
      Glomerulus, Ectasia                  |                                        2                                 |             
      Renal Tubule, Casts Protein          |                1           2           1  2                              |             
      Renal Tubule, Ectasia                |                1           2           2  2                              |             
      Renal Tubule, Mineralization         | 1                    2           2                 2                     |             
      Renal Tubule, Necrosis               |             1  2           2        1  1  2     1                        |             
      Renal Tubule, Pigmentation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 4| 5| 6| 7| 2| 7| 7| 7| 0| 7| 6| 7| 7| 1| 4| 4| 4| 4|             
                             DAY ON TEST   | 2| 5| 3| 2| 2| 2| 2| 3| 3| 4| 2| 6| 1| 2| 2| 9| 2| 3| 2| 2| 6| 5| 5| 5| 5|             
                                           | 9| 4| 7| 9| 9| 9| 9| 6| 8| 0| 9| 0| 5| 9| 9| 0| 9| 4| 9| 9| 8| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Regeneration           | 2     1  2     2  2        2  1     2  2  2     2     2  2               |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +                                                         |             
      Calculus Micro Observation Only      |                X                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    | 2        2  2     2                 2                 2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|             
                             DAY ON TEST   | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|             
                                           | 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  M  +               |             
      Infiltration Cellular, Lymphocyte    |    2                    2  2        2     2     2                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cytomegaly                           |                                                 3                        |             
      Fatty Change                         |                1                                2                        |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |       3  2  1           1           1                                    |             
      Infiltration Cellular, Lymphocyte    |                   2                       2  2        2  2               |             
      Necrosis                             |    4                                                                     |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Portal, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                    2  2  2               |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |    2     2  2  2  2     2  2  2     2  2  2  2  2  2  2  2               |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
      Hyperplasia, Squamous                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |          2                                         2  2                  |             
      Inflammation, Acute                  |                   1        3              2              2               |             
      Inflammation, Chronic Active         |                         1                                                |             
      Mineralization                       |                                                                          |             
      Mucosa, Ectasia                      |                            2        2                                    |             
      Mucosa, Erosion                      |                         2                                2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|             
                             DAY ON TEST   | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|             
                                           | 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Pulp, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |          2                          1  1                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cyst                                 |                                                                          |             
      Hypertrophy                          |                            2        2                                    |             
      Spindle Cell, Hyperplasia            | 2  2  2  2  2  2  2     2  2  1     2  2  2  2  2  2  2  2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  M  M     +  +  +  +  +  +  M  M  +  M  M  M               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +               |             
      Pars Distalis, Hyperplasia           |                                                       2                  |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Ectasia                    |                                                 2                        |             
      Follicle, Hyperplasia                |                         2  1           2  2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |                   1        1  2     2  2  2  1  2  2  2  2               |             
                                            __________________________________________________________________________|             
   Penis                                   |                                  +                                       |             
      Inflammation, Acute                  |                                  4                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +              +     +           +  +                           |             
      Abscess                              |                         4                                                |             
      Inflammation, Chronic                |          2                                3                              |             
      Inflammation, Chronic Active         |                                              3                           |             
      Duct, Cyst                           |                               X                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Ectasia                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                    2                     |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|             
                             DAY ON TEST   | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|             
                                           | 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Ectasia                              |                                                 2                        |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mineralization                       |                                                                          |             
      Interstitial Cell, Hyperplasia       |             2  2              2     2     2  2  2        2               |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
      Atypia Cellular                      |    X                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |    2     2  2  2  2        2  2     2  2  2     2  2     2               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia, Lymphoid                | 2        2  2  1  2     2  2  2     2  2  2  2  2  2  2  2               |             
      Pigmentation                         |             2     2                 2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
      Congestion                           |          3                 3              2           3  2               |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |    2     2  2  2        2  2  2     2  2  2  2     2     2               |             
      Hyperplasia                          |                                                       2                  |             
      Inflammation, Acute                  |                   2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
      Angiectasis                          |    2                                                                     |             
      Hematopoietic Cell Proliferation     | 2  3     4     1  3     2  2                          2  2               |             
      Hyperplasia, Lymphoid                |             2                                      2     2               |             
      Pigmentation                         |                         2  2           2  1  2     1                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +  +               |             
      Cyst                                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M     M  M  M  M  M  M  M  M  M  M  M  M               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |             3     3     3  3              3  2        2                  |             
      Inflammation, Chronic Active         |       3                 3  3           4                                 |             
      Metaplasia, Osseous                  |                            4                                             |             
      Ulcer                                |       3                 3              4  4              4               |             
      Subcutaneous Tissue, Abscess         |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|             
                             DAY ON TEST   | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|             
                                           | 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mineralization                       | 2  2  2  1  2     2     2  2     2  2  2  2  2  1  2     2               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                              2                           |             
      Hemorrhage                           |                                        1           2                     |             
      Infiltration Cellular, Lymphocyte    | 2  2     2  2  2  2     2  2  2  2  2     2  2  2  2  2  2               |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                            2                                             |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                               3                                          |             
      Alveolus, Inflammation, Acute        |                                                                          |             
      Bronchiole, Inflammation, Acute      |                                        1                                 |             
      Bronchiole, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Interstitium, Inflammation, Acute    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Lumen, Hemorrhage                    | 2  2        2     2     2  1           1        2     2  2               |             
      Mucosa, Inflammation, Acute          |                2                                                         |             
      Nasolacrimal Duct, Hemorrhage        |                                                    1                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Degeneration   | 2  2  2  2  2     2     2  2     1  1              2  2  2               |             
      Respiratory Epithelium, Degeneration |                   2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |    2  2  3     1  2     2  2  2  2  2  2  2  2  2  2  2  2               |             
      Metaplasia, Osseous                  |    2        2                                                            |             
      Glomerulus, Ectasia                  |                                                                          |             
      Renal Tubule, Casts Protein          |                                                                          |             
      Renal Tubule, Ectasia                | 2                                                                        |             
      Renal Tubule, Mineralization         | 2              2              1     1           1                        |             
      Renal Tubule, Necrosis               |                1                                         2               |             
      Renal Tubule, Pigmentation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 4| 3| 4|             
                             DAY ON TEST   | 4| 8| 7| 3| 2| 2| 0| 0| 2| 2| 2| 7| 2| 2| 2| 2| 3| 3| 3| 3| 7| 5| 5| 1| 5|             
                                           | 0| 0| 5| 9| 9| 9| 7| 4| 9| 9| 9| 2| 9| 9| 9| 9| 0| 0| 0| 0| 2| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Regeneration           |                2  2     2  1  2     2  2  1  2  1  2  2  2               |             
                                            __________________________________________________________________________|             
   Urethra                                 |             +  +        +                       +                        |             
      Calculus Micro Observation Only      |             X  X        X                       X                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |          2     2  2     2  1  2              2     1     2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 2| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  44        |
      Infiltration Cellular, Lymphocyte    |    2  2  1        2     2  2                                             |     15  1.9|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +                                             |  46        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Cytomegaly                           |                                                                          |      1  3.0|
      Fatty Change                         |                                                                          |      3  1.7|
      Focal Cellular Change                |    X                                                                     |      2     |
      Hematopoietic Cell Proliferation     |          2        1                                                      |      9  1.6|
      Infiltration Cellular, Lymphocyte    |       2                 2                                                |     12  1.8|
      Necrosis                             |                                                                          |      3  3.3|
      Vacuolization Cytoplasmic            |             1                                                            |      1  1.0|
      Portal, Inflammation, Chronic        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Infiltration Cellular                |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    | 2        2              1                                                |      7  1.9|
      Acinus, Hyperplasia                  | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    |    2  2  2  2     2     2  2                                             |     38  2.0|
      Acinus, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Hyperplasia, Squamous                |    2                                                                     |      3  2.3|
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  1.7|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Infiltration Cellular, Lymphocyte    | 2                 2  2  2  1                                             |     13  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 2| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      5  2.2|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      2  2.0|
      Mucosa, Ectasia                      |          2              1                                                |      4  1.8|
      Mucosa, Erosion                      |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Pulp, Inflammation, Chronic Active   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    |                   1                                                      |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Cyst                                 |       X                                                                  |      1     |
      Hypertrophy                          | 2  2     2        2                                                      |      7  2.0|
      Spindle Cell, Hyperplasia            | 2  2  2  2  2  2  2  2  2  2                                             |     48  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  M  +  +  +  +  +  +                                             |  25        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +                                             |  47        |
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.0|
      Pars Intermedia, Cyst                |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |          1                                                               |      1  1.0|
      Follicle, Ectasia                    |                                                                          |      1  2.0|
      Follicle, Hyperplasia                |                                                                          |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    |       2  2  2           2  2                                             |     19  1.8|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 2| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +                                                                  |  13        |
      Abscess                              |       4                                                                  |      4  4.0|
      Inflammation, Chronic                |    3                                                                     |      3  2.7|
      Inflammation, Chronic Active         |                                                                          |      4  3.3|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Ectasia                              |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Ectasia                              |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Mineralization                       |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |       2  2        2                                                      |     16  2.0|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Atypia Cellular                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Myelofibrosis                        |                                                                          |      2  2.0|
      Myeloid Cell, Hyperplasia            | 2  2  2  2  2     2  2  2  2                                             |     35  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia, Lymphoid                | 2  2  2  2  2     2  2  3  2                                             |     40  2.0|
      Pigmentation                         |             2                                                            |     10  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Congestion                           |             2     2  2     2                                             |     12  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                | 2  2  3  2  2     2  2     2                                             |     33  2.1|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 2     2     2     1                                                      |     26  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 2| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      7  2.0|
      Pigmentation                         |          1  1                                                            |     11  1.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +                                             |  47        |
      Cyst                                 | X     X           X                                                      |      8     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |          2                                                               |     18  2.5|
      Inflammation, Chronic Active         |                                                                          |      4  3.3|
      Metaplasia, Osseous                  |                                                                          |      1  4.0|
      Ulcer                                |                3                                                         |      8  3.6|
      Subcutaneous Tissue, Abscess         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Mineralization                       | 2  1  2     2     2  2  2  2                                             |     40  1.9|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Congestion                           |                2                                                         |      4  2.3|
      Hemorrhage                           | 2                                                                        |      5  1.6|
      Infiltration Cellular, Lymphocyte    | 2  2  2  1  2  2  1  2  2  2                                             |     42  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |      4  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       2     2                                                            |      6  2.2|
      Alveolus, Inflammation, Acute        |       1                                                                  |      1  1.0|
      Bronchiole, Inflammation, Acute      |                         1                                                |      4  1.0|
      Bronchiole, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Interstitium, Inflammation, Acute    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Lumen, Hemorrhage                    | 2  2  2           1  2  2                                                |     24  1.9|
      Mucosa, Inflammation, Acute          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 2| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Hemorrhage        |             2                                                            |      3  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Olfactory Epithelium, Degeneration   |          2  1  2  2  2  2  2                                             |     26  1.9|
      Respiratory Epithelium, Degeneration |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2     2  2  2  2                                             |     43  2.0|
      Metaplasia, Osseous                  | 2                                                                        |      3  2.0|
      Glomerulus, Ectasia                  |                                                                          |      1  2.0|
      Renal Tubule, Casts Protein          |                                                                          |      4  1.5|
      Renal Tubule, Ectasia                | 3           1           2                                                |      8  1.9|
      Renal Tubule, Mineralization         | 2  2           2                                                         |     12  1.7|
      Renal Tubule, Necrosis               | 2     2     1     2        2                                             |     14  1.6|
      Renal Tubule, Pigmentation           |                   1                                                      |      1  1.0|
      Renal Tubule, Regeneration           | 2  2  2     2     2     2  1                                             |     33  1.8|
                                            __________________________________________________________________________|____________|
   Urethra                                 |             +  +     +     +                                             |   9        |
      Calculus Micro Observation Only      |             X  X     X     X                                             |      9     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +                                             |  47        |
      Infiltration Cellular, Lymphocyte    |    2     2        2     2  2                                             |     20  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2     2  2     2  2                    2                 2     2  2  2|             
      Epithelium, Degeneration             |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Focal Cellular Change                |       X                                                                  |             
      Hematopoietic Cell Proliferation     | 3                          1        1                          1         |             
      Infarct                              |                         4                                                |             
      Infiltration Cellular, Lymphocyte    |       2                                                              2   |             
      Necrosis                             |                      2     1                                             |             
      Bile Duct, Cyst                      |          X                                                               |             
      Hepatocyte, Hypertrophy              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1           2                 2        2                       2      |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Cyst                           |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2                 2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Erosion                              |                                                                   2      |             
      Hyperplasia, Squamous                | 3  2           1                 2        3                       1     3|             
      Infiltration Cellular, Lymphocyte    |                                                                      2   |             
      Inflammation, Acute                  |       1                                                           3      |             
      Inflammation, Chronic Active         |                                                                         2|             
      Mineralization                       |          1                                                     1     3   |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Erosion                              |                                     2                                    |             
      Infiltration Cellular, Lymphocyte    | 2  2        2  2  2        2  2           2                 2     1      |             
      Inflammation, Acute                  |                                  1                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                   1        2           2                       3     3   |             
      Mucosa, Ectasia                      |    2     2                                                               |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Ulcer                        |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Pulp, Inflammation, Chronic          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                1                    2                                    |             
      Inflammation, Acute                  |                                        2                                 |             
      Inflammation, Chronic                |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |             2     2           2        2                    2            |             
      Spindle Cell, Hyperplasia, Lymphoid  |                                                                   2      |             
      Spindle Cell, Hyperplasia            | 2  2  2  2  2  2  2     2  2  2  2  2  2  2                 2  2     2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  M  M  M  M  M  M  M  M  M  M                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  M|             
      Pars Distalis, Cyst                  |    X     X                                                               |             
      Pars Distalis, Hyperplasia           |          2                                                               |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |             2                                                            |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Ectasia                    |                                                                      2   |             
      Follicle, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1  2     2  2  2  2  2     2  2  2  2  2                          2   |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +              +                                                     +|             
      Abscess                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                         3|             
      Inflammation, Chronic                |    3              2                                                      |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Cyst                           |                   X                                                      |             
      Duct, Ectasia                        |    2                                                                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Ectasia                              |                                        4                                 |             
      Infiltration Cellular, Lymphocyte    |             2                                                           1|             
      Inflammation, Chronic                |                                        3                                 |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Atrophy                              |                               2                                          |             
      Granuloma Sperm                      |                                                                          |             
      Mineralization                       |                                                                          |             
      Spermatogenic Arrest                 |                               X                                          |             
      Interstitial Cell, Hyperplasia       |                2                 2     2  2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Myeloid Cell, Hyperplasia            | 2     2  2  2     2  2     2     2  2  2                    2     2     2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2  2  2  2  2  2  2  2  2  2  2  2  2  2                    2  2  2  2  2|             
      Hyperplasia                          |                                           2                              |             
      Pigmentation                         |                               2                             2        1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M                 +  +  M  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           | 2  2                 2                 3                    2  3         |             
      Hyperplasia, Lymphoid                | 2  2  2  2  3  1     2     2  2  2  2  3                    2  2     2  3|             
      Inflammation, Acute                  | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     | 3  2     2  2  2  3  4     4     2  3  2  3                 2  4  2     2|             
      Hyperplasia, Glandular               |                                                                          |             
      Hyperplasia, Lymphoid                |          2     2                                                         |             
      Pigmentation                         |             1                          2                                 |             
      Capsule, Inflammation, Chronic Active|                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cyst                                 |       X              X     X                                         X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M                 M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Erosion                              |                            2                                             |             
      Fibrosis, Focal                      |                                                                          |             
      Inflammation, Chronic                |    3           2        2  3     2     2                       2     4  2|             
      Inflammation, Chronic Active         |    3                                4                                    |             
      Ulcer                                |                                     4                                    |             
      Epithelium, Hyperplasia              |             2                                                            |             
      Prepuce, Inflammation, Acute         |                                                                          |             
      Prepuce, Ulcer                       |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mineralization                       | 2     2  2  2  2  2  2  2     2        2                          2     2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                   2                                                      |             
      Hemorrhage                           |          1                                                     2         |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  1  2  2  2  2  2  2  2  2  2  2                 2  2  2  2  2|             
      Alveolar Epithelium, Hyperplasia     |                                                                2         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Lumen, Hemorrhage                    | 1  1        2  2  1        3  1  2     2                    2     2  2  2|             
      Mucosa, Inflammation, Acute          |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 6| 3| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 1| 1| 5| 0| 7| 1| 1| 1| 1| 1| 7| 7| 7| 7| 7| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Nasolacrimal Duct, Hemorrhage        |          2                                                               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                1         |             
      Olfactory Epithelium, Degeneration   | 2  2  2  2              1     1     1                       2  2        2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2                 2  2  2  2  2|             
      Metaplasia, Osseous                  |                                                                2         |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Casts Protein          |                                  1                                       |             
      Renal Tubule, Ectasia                |    3                          1                                          |             
      Renal Tubule, Mineralization         |             1                    1                                       |             
      Renal Tubule, Necrosis               | 1  2        2        2  1  1        1  1  1                       2     1|             
      Renal Tubule, Regeneration           | 2  2  1  2     1  1  1  1  2  2  2  1  2  2                 2  2  2  2   |             
                                            __________________________________________________________________________|             
   Urethra                                 |             +  +        +                                         +     +|             
      Calculus Micro Observation Only      |             X  X        X                                         X     X|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2     2     1  2        2     2  2     2  2                 2  2  2      |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2        2                 1  2                                      1|             
      Epithelium, Degeneration             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
      Hyperplasia, Lymphoid                |    3                                                                     |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Focal Cellular Change                |       X                                                                  |             
      Hematopoietic Cell Proliferation     |                                  3                                       |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                               1     2                             2  2   |             
      Necrosis                             |                4  2                                                      |             
      Bile Duct, Cyst                      |                                                                          |             
      Hepatocyte, Hypertrophy              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                   3                                                      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2  2     2           1                                                |             
      Acinus, Atrophy                      |                   4                                                      |             
      Duct, Cyst                           |                   X                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 3  2  2  2  2  2     2  2  2  2     2  2                    2     3  2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Squamous                |       1     3     1           1                             2     2     2|             
      Infiltration Cellular, Lymphocyte    | 1     2                       2                                2         |             
      Inflammation, Acute                  |                                                                         2|             
      Inflammation, Chronic Active         |       2     3                                               2     2      |             
      Mineralization                       |                                                                      1  1|             
      Ulcer                                |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |       2                 2  2  1     2  2                       2  2  2   |             
      Inflammation, Acute                  |             2                                                            |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                         2|             
      Mucosa, Ectasia                      | 2                                                                        |             
      Mucosa, Inflammation, Acute          |                                     2                                    |             
      Mucosa, Ulcer                        |          2                                                               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Pulp, Inflammation, Chronic          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2                       2                                   2            |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                            2                                   1        2|             
      Spindle Cell, Hyperplasia, Lymphoid  |                                                                          |             
      Spindle Cell, Hyperplasia            | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2                    2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  M  M  M  M  M  +  M  M  M  M  M                 M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Pars Distalis, Cyst                  |                X                                                         |             
      Pars Distalis, Hyperplasia           |    2                          2                                         1|             
      Pars Intermedia, Cyst                |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2  2                          2                                       |             
      C-Cell, Hyperplasia                  |             2                                                            |             
      Follicle, Ectasia                    |                                                                          |             
      Follicle, Hyperplasia                |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1  2  2  2     2  1        1                                   2      |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +           +  +                 +                       +      |             
      Abscess                              |       4                                                                  |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |          2              2                                                |             
      Inflammation, Chronic Active         |    3                 4                    3                       3      |             
      Duct, Cyst                           |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2                             2                                       |             
      Inflammation, Chronic                |                   2                                                      |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Atrophy                              |                                                             2            |             
      Granuloma Sperm                      |                            3                                             |             
      Mineralization                       |                            2              3                              |             
      Spermatogenic Arrest                 |                                                                          |             
      Interstitial Cell, Hyperplasia       |                         2           2                                2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Reticulum Cell          | 3                                                                        |             
      Myeloid Cell, Hyperplasia            | 2  2  2  2  2     2  2  2     2  2  2  2                    2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |    2                                                                     |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
      Hyperplasia, Lymphoid                | 2  2  2  2     2  2  2  2  2  2  2  2  2                          2      |             
      Hyperplasia                          |                                                                          |             
      Pigmentation                         |    2                                                                 2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Angiectasis                          |       3                          3        3                              |             
      Congestion                           |             2        3  3                                                |             
      Hyperplasia, Lymphoid                |    4     2  2     3  2  2  2        3  2                    3  2  3  2  2|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  3  4  3  2     2  4  2  2                             2  2|             
      Hyperplasia, Glandular               |                                                                          |             
      Hyperplasia, Lymphoid                |          2  2                 3                             2     2  3  2|             
      Pigmentation                         | 1  2  1  2  2                                                           1|             
      Capsule, Inflammation, Chronic Active|                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cyst                                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  +  M  M  +                 M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Fibrosis, Focal                      | 2                                                                        |             
      Inflammation, Chronic                |    4     4  3           3  3  2     2  3                          3     2|             
      Inflammation, Chronic Active         |                      3                                                   |             
      Ulcer                                |    3                                                                 3   |             
      Epithelium, Hyperplasia              |                                                                          |             
      Prepuce, Inflammation, Acute         |                                                                          |             
      Prepuce, Ulcer                       |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
      Abscess                              |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mineralization                       |    2  1  2        2     2  2  2        2  2                 2     2  2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                                             3  3        2|             
      Hemorrhage                           |                            2                                             |             
      Infiltration Cellular, Lymphocyte    | 2     2  2  2  2  2  2  2  2  2     2  2                       2  2  2  2|             
      Alveolar Epithelium, Hyperplasia     |    2                                                                     |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    2                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  M  +  +  +|             
      Lumen, Hemorrhage                    |    2  1     2     3  3  3              2                          2  1  1|             
      Mucosa, Inflammation, Acute          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 7| 1| 3| 3| 1| 0| 3| 3| 3| 5| 5| 5| 5| 5| 0| 1| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 2| 7| 1| 1| 3| 9| 1| 1| 4| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Degeneration   | 2  2  2  2           2                 2                          2     1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
      Atrophy                              |       3                                                                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  2  2  2  2  1  2  2  2  2                    2  1  2  2  2|             
      Metaplasia, Osseous                  |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Casts Protein          |          2           2                                                   |             
      Renal Tubule, Ectasia                |          3           2                                                   |             
      Renal Tubule, Mineralization         |                                                                      1   |             
      Renal Tubule, Necrosis               |    1     3        1  2     1  1     1                             2      |             
      Renal Tubule, Regeneration           | 1  1  1  3  2     2  2  2  1  2     1                             1  2  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |       +           +              +  +                             +  +   |             
      Calculus Micro Observation Only      |       X           X              X  X                                X   |             
      Infiltration Cellular, Lymphocyte    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2  2  2           2  2     2  1  2                          2  1  2|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6| 7| 7| 1| 1| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3|                                            |            |
                                           | 0| 5| 4| 8| 4| 7| 0| 0| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    |    2                    1  2                                             |     18  1.8|
      Epithelium, Degeneration             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Serosa, Inflammation, Chronic Active |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  M  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  M  +  +  +                                             |  49        |
      Serosa, Inflammation, Chronic Active |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Serosa, Inflammation, Chronic Active |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                            3                                             |      1  3.0|
      Focal Cellular Change                |                                                                          |      2     |
      Hematopoietic Cell Proliferation     |          1              1                                                |      7  1.6|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                            2                                             |      7  1.9|
      Necrosis                             |                                                                          |      4  2.3|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Hepatocyte, Hypertrophy              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                                  |   3        |
      Hemorrhage                           |       3                                                                  |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                            2                                             |     10  1.8|
      Acinus, Atrophy                      |                                                                          |      1  4.0|
      Duct, Cyst                           |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    |    2  2  2  2           1  2                                             |     42  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia, Squamous                | 3  2     2  2           3                                                |     19  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6| 7| 7| 1| 1| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3|                                            |            |
                                           | 0| 5| 4| 8| 4| 7| 0| 0| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Lymphocyte    |             2                                                            |      6  1.8|
      Inflammation, Acute                  | 1        2                                                               |      5  1.8|
      Inflammation, Chronic Active         |    3                    2                                                |      7  2.3|
      Mineralization                       |       1                                                                  |      6  1.3|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Erosion                              |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |          2  2           2                                                |     22  1.9|
      Inflammation, Acute                  |                                                                          |      2  1.5|
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
      Mineralization                       |       2  1  2                                                            |      9  2.0|
      Mucosa, Ectasia                      |                                                                          |      3  2.0|
      Mucosa, Inflammation, Acute          |                                                                          |      1  2.0|
      Mucosa, Ulcer                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |   1        |
      Pulp, Inflammation, Chronic          |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |             2           2                                                |      7  1.9|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                            2                                             |      1  2.0|
      Hypertrophy                          |       1                 2  2                                             |     11  1.8|
      Spindle Cell, Hyperplasia, Lymphoid  |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            | 2  2  2  2  2     2  1  2  2                                             |     46  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  +  M                                             |  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Pars Distalis, Cyst                  |                                                                          |      3     |
      Pars Distalis, Hyperplasia           |                                                                          |      4  1.8|
      Pars Intermedia, Cyst                |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6| 7| 7| 1| 1| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3|                                            |            |
                                           | 0| 5| 4| 8| 4| 7| 0| 0| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      4  2.0|
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
      Follicle, Ectasia                    |                                                                          |      1  2.0|
      Follicle, Hyperplasia                |          1                                                               |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |       2     1           2  2                                             |     25  1.8|
      Serosa, Inflammation, Chronic Active |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |       +           +  +                                                   |   3        |
      Inflammation, Acute                  |                   4  2                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +                                                                  |  11        |
      Abscess                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      4  2.3|
      Inflammation, Chronic Active         |       3                                                                  |      5  3.2|
      Duct, Cyst                           |                                                                          |      1     |
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | M  +  +  +  +  +  +  +  +  +                                             |  49        |
      Ectasia                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      4  1.8|
      Inflammation, Chronic                |                      3                                                   |      3  2.7|
      Serosa, Inflammation, Chronic Active |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Atrophy                              |                                                                          |      2  2.0|
      Granuloma Sperm                      |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      2  2.5|
      Spermatogenic Arrest                 |                                                                          |      1     |
      Interstitial Cell, Hyperplasia       |                         2  2                                             |      9  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                            3                                             |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6| 7| 7| 1| 1| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3|                                            |            |
                                           | 0| 5| 4| 8| 4| 7| 0| 0| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |    2     2  2        2  2  2                                             |     36  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Iliac, Hyperplasia, Lymphoid         |                   3                                                      |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia, Lymphoid                |          2  2           2  2                                             |     37  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Pigmentation                         |    2  1  2                                                               |      9  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +                                             |  46        |
      Angiectasis                          |                                                                          |      3  3.0|
      Congestion                           |                         3                                                |     10  2.5|
      Hyperplasia, Lymphoid                |          2  2     2     3  3                                             |     35  2.3|
      Inflammation, Acute                  |    3  2                                                                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  M  +                                             |  49        |
      Atrophy                              | 3     2                                                                  |      2  2.5|
      Hematopoietic Cell Proliferation     |    2              4  3     2                                             |     35  2.5|
      Hyperplasia, Glandular               |                            2                                             |      1  2.0|
      Hyperplasia, Lymphoid                |             2                                                            |     10  2.2|
      Pigmentation                         |       2                                                                  |      9  1.6|
      Capsule, Inflammation, Chronic Active|    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Cyst                                 |    X  X                 X  X                                             |      9     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Erosion                              |                                                                          |      1  2.0|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Inflammation, Chronic                | 3              2  2  2  1                                                |     24  2.5|
      Inflammation, Chronic Active         |                                                                          |      3  3.3|
      Ulcer                                | 4              4                                                         |      5  3.6|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
      Prepuce, Inflammation, Acute         |       2                                                                  |      1  2.0|
      Prepuce, Ulcer                       |                      4                                                   |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6| 7| 7| 1| 1| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3|                                            |            |
                                           | 0| 5| 4| 8| 4| 7| 0| 0| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Abscess                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mineralization                       |    2     1  2        2     1                                             |     29  1.9|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      4  2.5|
      Hemorrhage                           |    2                                                                     |      4  1.8|
      Infiltration Cellular, Lymphocyte    |    2  2  2  2        2  2  2                                             |     43  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Lumen, Hemorrhage                    | 2  2        1        2  2  2                                             |     29  1.9|
      Mucosa, Inflammation, Acute          | 2     2                                                                  |      3  1.7|
      Nasolacrimal Duct, Hemorrhage        |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
      Olfactory Epithelium, Degeneration   | 2     2  2              1  2                                             |     23  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |    2  1  2  2  2        2  2                                             |     46  1.9|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Pelvis, Inflammation, Acute          | 3              2                                                         |      2  2.5|
      Renal Tubule, Casts Protein          | 2                                                                        |      4  1.8|
      Renal Tubule, Ectasia                |                2  2  2                                                   |      7  2.1|
      Renal Tubule, Mineralization         |                         1  2                                             |      5  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6| 7| 7| 1| 1| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 4| 4| 0| 3| 4| 5| 7| 3| 3|                                            |            |
                                           | 0| 5| 4| 8| 4| 7| 0| 0| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Necrosis               | 1  2                    1  1                                             |     23  1.4|
      Renal Tubule, Regeneration           |    2        1           2  2                                             |     36  1.7|
                                            __________________________________________________________________________|____________|
   Urethra                                 |    +     +     +        +                                                |  15        |
      Calculus Micro Observation Only      |    X     X     X        X                                                |     14     |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |             2              2                                             |     25  1.9|
      Inflammation, Chronic                | 2              3                                                         |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 3| 4| 4| 4| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 5| 5| 5| 9| 5| 7| 0| 3| 3| 0| 3| 3| 3|             
                                           | 1| 8| 4| 4| 4| 4| 6| 4| 4| 4| 1| 1| 7| 7| 7| 8| 1| 2| 5| 4| 3| 9| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +           +  +                          +  +  +  +     M  +         |             
      Ectasia                              | 3                                                                        |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +        +  +  +                          +  +  +  +     +  +         |             
      Developmental Malformation           |                                                             X            |             
      Focal Cellular Change                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |             2  2                                   1  2                  |             
      Necrosis                             |                                              3  2                        |             
      Bile Duct, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +        +                    +                           |             
      Fat, Necrosis                        |                         4                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +           +  +                          +  +  +  +     +  +         |             
      Infiltration Cellular, Lymphocyte    |                2                                2                        |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +           +  +                          +  +  +  +     +  +         |             
      Infiltration Cellular, Lymphocyte    |                2  2                          2  2     2                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute                  |                                                                   2      |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |             1        1                                                   |             
      Glandular, Cyst Epithelial Inclusion |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |             2           2                                         2      |             
      Inflammation, Acute                  |                                                                      2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                             2            |             
      Mucosa, Dilatation                   |                                                                          |             
      Mucosa, Ectasia                      |       2                                                                  |             
      Mucosa, Mineralization               |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 3| 4| 4| 4| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 5| 5| 5| 9| 5| 7| 0| 3| 3| 0| 3| 3| 3|             
                                           | 1| 8| 4| 4| 4| 4| 6| 4| 4| 4| 1| 1| 7| 7| 7| 8| 1| 2| 5| 4| 3| 9| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +           +  +                          +  +  +  +     +  +         |             
      Mineralization                       |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +           +  +                          +  +  +  +     +  +         |             
      Spindle Cell, Hyperplasia, Lymphoid  |                                                                2         |             
      Spindle Cell, Hyperplasia            | 2  2           2  2                          2  2  2  2     2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +           +  +                          +  +  +  +     +  +         |             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M           M  +                          +  +  +  M     +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +           +  +                          +  +  +  +     +  +         |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Follicle, Ectasia                    |                                                 2                        |             
      Follicle, Hyperplasia, Cystic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +           +  +                          +  +  +  +     +  +         |             
      Infiltration Cellular, Lymphocyte    | 2              2                                      2                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                 +           M     +     +|             
      Abscess                              |                                                 4                        |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                   2     4|             
      Duct, Cyst                           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +           +  +                          +  +  +  +     +  +         |             
      Mineralization                       |                                                             2            |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +           +  +                          +  +  +  +     +  +         |             
      Myeloid Cell, Hyperplasia            | 2              2  2                          2  2  2           2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +     +  +     +                    +  +  +  +     +  +  +     +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                 2              3         |             
      Mediastinal, Congestion              |                                                       2                  |             
      Mediastinal, Hyperplasia, Lymphoid   |                2                             2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +           +  +                          +  +  +  +     M  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 3| 4| 4| 4| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 5| 5| 5| 9| 5| 7| 0| 3| 3| 0| 3| 3| 3|             
                                           | 1| 8| 4| 4| 4| 4| 6| 4| 4| 4| 1| 1| 7| 7| 7| 8| 1| 2| 5| 4| 3| 9| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 2  2                     |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +     +  +     +                    +  +  +  +     +  +  +     +|             
      Angiectasis                          |                                                       3                  |             
      Congestion                           | 4        3              2                    3                    3     3|             
      Hemorrhage                           |                4  4                                                      |             
      Hyperplasia, Lymphoid                |          2     3        3                       2  2           2         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +           +  +                          +  +  +  +     +  +         |             
      Hematopoietic Cell Proliferation     | 2              3  2                                3  2     2  2         |             
      Hyperplasia, Lymphoid                |                                                 2              2         |             
      Pigmentation                         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +           +  +                          +  +  +  +     +  +         |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M           M  M                          M  M  M  M     M  M         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +     +  +  +  +  +                 +  +  +  +  +  +  +  +      |             
      Alopecia                             |                                                                          |             
      Angiectasis                          |                                                                          |             
      Erosion                              |                            2                                             |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 2                 3  2  3  3                    3                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |          4        3                                                      |             
      Prepuce, Inflammation, Chronic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +           +  +                          +  +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +           +  +                          +  +  +  +     +  +         |             
      Mineralization                       |    2           2  2                             2  2                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +           +  +     +                    +  +  +  +     +  +         |             
      Congestion                           |                   2                                                      |             
      Hemorrhage                           |                         2                                                |             
      Infiltration Cellular, Lymphocyte    |                2                                2  2  2     2  1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +           +  +                          +  +  +  +     +  +         |             
      Lumen, Hemorrhage                    |                                                 2              2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 3| 4| 4| 4| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 5| 5| 5| 9| 5| 7| 0| 3| 3| 0| 3| 3| 3|             
                                           | 1| 8| 4| 4| 4| 4| 6| 4| 4| 4| 1| 1| 7| 7| 7| 8| 1| 2| 5| 4| 3| 9| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           | 2                                            2        2                  |             
      Olfactory Epithelium, Degeneration   |                1                             1  1  2           2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +           +  +                          +  +  +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +           +  +                          +  +  +  +     +  +         |             
      Congestion                           | 3                                                                        |             
      Hemorrhage                           |                3                                                         |             
      Infiltration Cellular, Lymphocyte    | 1              2  1                          2     2  2     2  2         |             
      Inflammation, Chronic                |                                                 2                        |             
      Glomerulus, Renal Tubule,            |                                                                          |             
          Mineralization                   |                                              4                           |             
      Renal Tubule, Ectasia                |                                                 2                        |             
      Renal Tubule, Mineralization         |                   2                                                      |             
      Renal Tubule, Necrosis               |                                                    2                     |             
      Renal Tubule, Regeneration           |                                                    2           1         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                              +              +            |             
      Calculus Micro Observation Only      |                                              X              X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +           +  +                          +  +  +  +     +  +         |             
      Ectasia                              |                   2                                                      |             
      Infiltration Cellular, Lymphocyte    |                2                                2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 0| 3| 3|             
                                           | 6| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 7| 8| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +              M              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +              +              +                             +  +  +      |             
      Ectasia                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                2  2      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +              +              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +              +              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +              +              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +              +              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +              +              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +              +              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +              +              M                             +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +              +              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +        +  +  +     +  +  +                             +  +  +  +   |             
      Developmental Malformation           |                                                                          |             
      Focal Cellular Change                |                X                                                         |             
      Infiltration Cellular, Lymphocyte    |                1                                                         |             
      Necrosis                             |                                                                   4      |             
      Bile Duct, Cyst                      |                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                            +      |             
      Fat, Necrosis                        |                      4                                            3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +              +              +                             +  +  +      |             
      Infiltration Cellular, Lymphocyte    |                2                                                         |             
      Acinus, Atrophy                      |                               2                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +              +              +                             +  +  +      |             
      Infiltration Cellular, Lymphocyte    | 2              2              1                                   2      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                              1                           |             
      Hyperplasia, Squamous                | 2        2                             2     1                           |             
      Inflammation, Acute                  | 2                    2                                                   |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Mineralization                       |                                                                          |             
      Glandular, Cyst Epithelial Inclusion | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                2        2           2  2  2  2                           |             
      Inflammation, Acute                  |                                                                      2   |             
      Inflammation, Chronic Active         | 4                                                                        |             
      Mineralization                       |                                  2                                       |             
      Mucosa, Dilatation                   |                                                                          |             
      Mucosa, Ectasia                      |                                                                          |             
      Mucosa, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 0| 3| 3|             
                                           | 6| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 7| 8| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +              +              +                             +  +  +      |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +              +              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +              +              +                             +  +  +      |             
      Spindle Cell, Hyperplasia, Lymphoid  |                                                                          |             
      Spindle Cell, Hyperplasia            | 2                             2                             2  2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +              +              +                             +  +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +              +              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M              M              M                             M  M  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M              +              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +              M           +  +                             +  +  +      |             
      Infiltration Cellular, Lymphocyte    |                                                                   2      |             
      Follicle, Ectasia                    |                                                                          |             
      Follicle, Hyperplasia, Cystic        |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +              +              +                             +  +  +      |             
      Infiltration Cellular, Lymphocyte    |                               2                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +     +           +  +     +     +  +           +               |             
      Abscess                              |          3     4              4                          4               |             
      Infiltration Cellular, Lymphocyte    |                            2              3  2                           |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |    3                                                                     |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +              +              +              +              +  +  +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +              +              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +              +              +                             +  +  +      |             
      Mineralization                       |                               2                                   2      |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +           +  +              +                             +  +  +      |             
      Myeloid Cell, Hyperplasia            | 2           3                 2                             2  2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +        +  +        +  +                 +  +  +      |             
      Inguinal, Hyperplasia, Lymphoid      |                               3                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +              +              +                             +  +  M      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 0| 3| 3|             
                                           | 6| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 7| 8| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                2                                               2         |             
      Pigmentation                         |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +        +  +        +  +                 +  +  +      |             
      Angiectasis                          |                                                             3            |             
      Congestion                           |                3           3              2                              |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |    3           2  2        2              2                    2  3      |             
      Inflammation, Acute                  |       3                                                                  |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +  +              +     +              +  +     +  +  +      |             
      Hematopoietic Cell Proliferation     |       3        3              3                             2  3  2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +              +              +        +                    +  +  +      |             
      Cyst                                 |                                                             X            |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M              M              M                             M  M  M      |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +|             
      Alopecia                             |                                                       2                  |             
      Angiectasis                          |                                                 3                        |             
      Erosion                              |                                                                          |             
      Hyperplasia                          |                                                 2                        |             
      Inflammation, Chronic                |          3                                               3        3     2|             
      Inflammation, Chronic Active         |                                                    3                     |             
      Ulcer                                |          3                                               3     4         |             
      Prepuce, Inflammation, Chronic       |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +              +              +                             +  +  +      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +              +              +                             +  +  +      |             
      Mineralization                       | 2              2              2                                2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +              +     +        +                       +  +  +  +  +      |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 2              2                                         2  2  2  2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +              +              +                             +  +  +      |             
      Lumen, Hemorrhage                    |                2                                               2  2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 0| 3| 3|             
                                           | 6| 4| 4| 4| 4| 8| 4| 4| 4| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 7| 8| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                             1            |             
      Olfactory Epithelium, Degeneration   |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +              +              +                             +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                    +                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +              +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +              +              +                             +  +  +      |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                               2                             2  2  2      |             
      Inflammation, Chronic                |                3                                                         |             
      Glomerulus, Renal Tubule,            |                                                                          |             
          Mineralization                   |                                                                          |             
      Renal Tubule, Ectasia                |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Regeneration           |                                                                1         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +              +                                +         |             
      Calculus Micro Observation Only      |                X              X                                X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +              +              +                             +  +  +      |             
      Ectasia                              |                                                                2         |             
      Infiltration Cellular, Lymphocyte    |                               2                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 7| 7| 7| 7| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  15        |
      Ectasia                              |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  23        |
      Developmental Malformation           |                                                                          |      1     |
      Focal Cellular Change                |                                                                          |      1     |
      Infiltration Cellular, Lymphocyte    |                                                                          |      5  1.6|
      Necrosis                             |                                                                          |      3  3.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Fat, Necrosis                        |                                                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                   +                                                      |  17        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  2.0|
      Acinus, Atrophy                      |                   4                                                      |      2  3.0|
      Duct, Cyst                           |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  16        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      9  1.9|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +  +  +  +                                             |  50        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Hyperplasia, Squamous                |                                                                          |      4  1.8|
      Inflammation, Acute                  |                                                                          |      3  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  1.0|
      Glandular, Cyst Epithelial Inclusion |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                         2                                                |     10  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 7| 7| 7| 7| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Dilatation                   |                   2                                                      |      1  2.0|
      Mucosa, Ectasia                      |                                                                          |      1  2.0|
      Mucosa, Mineralization               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  16        |
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  16        |
      Spindle Cell, Hyperplasia, Lymphoid  |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            |                                                                          |     14  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  16        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                   +                                                      |  17        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  16        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Follicle, Ectasia                    |                                                                          |      1  2.0|
      Follicle, Hyperplasia, Cystic        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  16        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                   +        +                                             |  14        |
      Abscess                              |                                                                          |      5  3.8|
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  2.3|
      Inflammation, Chronic                |                            3                                             |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
      Duct, Cyst                           |                   X                                                      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                   +                                                      |  17        |
      Mineralization                       |                                                                          |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 7| 7| 7| 7| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  17        |
      Myeloid Cell, Hyperplasia            |                                                                          |     12  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +                                                   |  28        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      3  2.7|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  14        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +  +                                                   |  28        |
      Angiectasis                          |                                                                          |      2  3.0|
      Congestion                           |                   2  3                                                   |     11  2.8|
      Hemorrhage                           |                                                                          |      2  4.0|
      Hyperplasia, Lymphoid                |                   2  3                                                   |     15  2.3|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  21        |
      Hematopoietic Cell Proliferation     |                                                                          |     13  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Pigmentation                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  16        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +  +                                             |  42        |
      Alopecia                             |                                                                          |      1  2.0|
      Angiectasis                          |                                                                          |      1  3.0|
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                2  4  4  3  3                                             |     15  2.9|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Ulcer                                |                   4                                                      |      6  3.5|
      Prepuce, Inflammation, Chronic       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 7| 7| 7| 7| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  16        |
      Mineralization                       |                                                                          |      9  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                         +                                                |  21        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |     12  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  16        |
      Lumen, Hemorrhage                    |                                                                          |      5  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      4  1.8|
      Olfactory Epithelium, Degeneration   |                                                                          |      6  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  16        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  16        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |     12  1.8|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Glomerulus, Renal Tubule,            |                                                                          |            |
          Mineralization                   |                                                                          |      1  4.0|
      Renal Tubule, Ectasia                |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   5        |
      Calculus Micro Observation Only      |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  16        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05007-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 08:05:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 5| 5| 5| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 7| 7| 7| 7| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Ectasia                              |                                                                          |      2  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------