National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2756

TDMS Study 05007-06 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           POLYSORBATE 80


NTP Experiment-Test: 05007-06                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: DOSED FEED                                                                                                 Time: 12:48:09




       Facility:  Southern Research Institute

       Chemical CAS #:  9005-65-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 12:48:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                               2            3            4                                                  
    Moribund                                          25           22           21                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           25           25                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (50)                                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
   Intestine Large, Cecum                             (50)         (48)         (49)                                                
   Intestine Large, Colon                             (50)         (49)         (50)                                                
   Intestine Large, Rectum                            (50)         (50)         (48)                                                
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Small, Duodenum                          (50)         (48)         (50)                                                
      Adenocarcinoma                                                1 (2%)                                                          
   Intestine Small, Ileum                             (50)         (48)         (49)                                                
   Intestine Small, Jejunum                           (50)         (48)         (49)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Adenoma                                        1 (2%)       3 (6%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Mesentery                                          (10)         (4)          (3)                                                 
   Pancreas                                           (50)         (47)         (50)                                                
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
   Stomach, Glandular                                 (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)       2 (4%)                                                          
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Pheochromocytoma NOS                             6 (12%)      6 (12%)      7 (14%)                                            
                                                             Page   2                                                               
NTP Experiment-Test: 05007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 12:48:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Islets, Pancreatic                                 (50)         (47)         (50)                                                
      Adenoma                                                       2 (4%)                                                          
   Parathyroid Gland                                  (41)         (41)         (41)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Pars Distalis, Adenoma                          37 (74%)     30 (60%)     36 (72%)                                            
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Distalis, Histiocytic Sarcoma                            1 (2%)                                                          
      Pars Intermedia, Adenoma                         2 (4%)                                                                       
      Pars Intermedia, Carcinoma                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Thymoma Malignant, Metastatic, Thymus                                      1 (2%)                                             
      C-Cell, Adenoma                                  5 (10%)      6 (12%)     10 (20%)                                            
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (49)         (50)                                                
      Adenoma                                          3 (6%)       3 (6%)       3 (6%)                                             
      Carcinoma                                        7 (15%)      5 (10%)      4 (8%)                                             
      Squamous Cell Carcinoma                                       1 (2%)       1 (2%)                                             
   Ovary                                              (50)         (50)         (50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)                                                
      Endometrium, Polyp Stromal                       9 (18%)     11 (22%)     12 (24%)                                            
      Endometrium, Sarcoma Stromal                                               1 (2%)                                             
   Vagina                                             (6)          (9)          (5)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)          (1)                                                              
   Bone Marrow                                        (50)         (50)         (50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                         (50)         (50)         (50)                                                
   Lymph Node, Mandibular                             (50)         (50)         (50)                                                
   Lymph Node, Mesenteric                             (50)         (50)         (50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
                                                             Page   3                                                               
NTP Experiment-Test: 05007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 12:48:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (47)         (46)         (47)                                                
      Thymoma Malignant                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (50)                                                
      Adenocarcinoma                                                2 (4%)       1 (2%)                                             
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                    28 (56%)     27 (56%)     26 (52%)                                            
   Skin                                               (50)         (50)         (50)                                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Head, Squamous Cell Papilloma                                 1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     2 (4%)       2 (4%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)                                                          
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (3)          (2)                                                 
      Lipoma                                                                     1 (50%)                                            
      Rhabdomyosarcoma                                 1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Carcinoma, Deep Invasion, Metastatic,                                                                                         
          Pituitary Gland                              2 (4%)                                                                       
      Oligodendroglioma Malignant                                   2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
   Nose                                               (50)         (50)         (50)                                                
      Nasolacrimal Duct, Squamous Cell Carcinoma                                 1 (2%)                                             
   Trachea                                            (50)         (50)         (50)                                                
      Thymoma Malignant, Metastatic, Thymus                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 12:48:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)          (2)                                                 
      Adenoma                                                                    1 (50%)                                            
      Squamous Cell Carcinoma                                                    1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leukemia Mononuclear                            26 (52%)     10 (20%)     13 (26%)                                            
      Lymphoma Malignant Mixed                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 12:48:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          48          48                                                   
     Total Primary Neoplasms                          138         118         124                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          44          46                                                   
     Total Benign Neoplasms                            91          87          93                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35          21          20                                                   
     Total Malignant Neoplasms                         41          25          24                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       1                                                   
     Total Metastatic Neoplasm                          2                       2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  6           6           7                                                   
     Total Uncertain Neoplasms                          6           6           7                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 12:48:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           27           25                                                  
    Dead                                               7            5            7                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           18           18                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (49)         (48)                                                
   Intestine Large, Colon                             (49)         (50)         (49)                                                
   Intestine Large, Rectum                            (48)         (49)         (49)                                                
   Intestine Small, Duodenum                          (49)         (50)         (49)                                                
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
   Intestine Small, Ileum                             (49)         (47)         (49)                                                
   Intestine Small, Jejunum                           (48)         (50)         (49)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Adenoma                           2 (4%)                    2 (4%)                                             
   Mesentery                                          (4)          (10)         (12)                                                
   Pancreas                                           (50)         (50)         (48)                                                
      Acinus, Adenoma                                  1 (2%)       2 (4%)       1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
   Stomach, Glandular                                 (49)         (50)         (50)                                                
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                                  1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Pheochromocytoma Malignant                       1 (2%)       4 (8%)       2 (4%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 12:48:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                         17 (34%)     12 (24%)     21 (42%)                                            
      Bilateral, Pheochromocytoma Benign               4 (8%)       4 (8%)       7 (14%)                                            
   Islets, Pancreatic                                 (50)         (48)         (48)                                                
      Adenoma                                          4 (8%)       5 (10%)      3 (6%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Pars Distalis, Adenoma                          30 (60%)     23 (47%)     26 (52%)                                            
      Pars Intermedia, Adenoma                         1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  6 (12%)      2 (4%)       2 (4%)                                             
      Follicle, Adenocarcinoma                                                   1 (2%)                                             
      Follicle, Adenoma                                             1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (50)                                                
   Preputial Gland                                    (48)         (50)         (49)                                                
      Adenoma                                          5 (10%)      1 (2%)       2 (4%)                                             
      Carcinoma                                        5 (10%)      6 (12%)      5 (10%)                                            
      Squamous Cell Carcinoma                                       1 (2%)       1 (2%)                                             
   Prostate                                           (50)         (50)         (50)                                                
   Seminal Vesicle                                    (50)         (50)         (50)                                                
   Testes                                             (49)         (50)         (50)                                                
      Interstitial Cell, Adenoma                      39 (80%)     35 (70%)     41 (82%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)          (4)          (1)                                                 
   Bone Marrow                                        (50)         (50)         (49)                                                
   Lymph Node                                         (49)         (50)         (50)                                                
   Lymph Node, Mandibular                             (49)         (50)         (48)                                                
   Lymph Node, Mesenteric                             (49)         (50)         (49)                                                
   Spleen                                             (50)         (50)         (50)                                                
      Sarcoma                                                                    2 (4%)                                             
   Thymus                                             (47)         (40)         (49)                                                
      Neoplasm NOS                                                  1 (3%)                                                          
      Thymoma NOS                                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 12:48:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (39)         (48)                                                
      Fibroadenoma                                     1 (2%)       2 (5%)                                                          
      Neurofibrosarcoma, Deep Invasion, Metastatic,                                                                                 
           Skin                                        1 (2%)                                                                       
   Skin                                               (49)         (50)         (50)                                                
      Basal Cell Carcinoma                                          2 (4%)       1 (2%)                                             
      Keratoacanthoma                                  2 (4%)       2 (4%)       5 (10%)                                            
      Squamous Cell Papilloma                          2 (4%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)       3 (6%)       4 (8%)                                             
      Subcutaneous Tissue, Lipoma                                   1 (2%)       2 (4%)                                             
      Subcutaneous Tissue, Neurofibroma                                          1 (2%)                                             
      Subcutaneous Tissue, Neurofibrosarcoma           1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Osteosarcoma                            1 (2%)                                                                       
   Skeletal Muscle                                                 (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma NOS                                                            1 (2%)                                             
      Hemangioma                                       1 (2%)                                                                       
      Neuroblastoma Malignant                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
      Mucosa, Squamous Cell Carcinoma                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (2)          (2)                                                 
      Canal, Squamous Cell Carcinoma                                             2 (100%)                                           
      Pinna, Neurofibroma                                           1 (50%)                                                         
   Eye                                                (10)         (11)         (14)                                                
      Lids, Squamous Cell Carcinoma                    1 (10%)                                                                      
                                                             Page   9                                                               
NTP Experiment-Test: 05007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 12:48:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - cont                                                                                                        
   Zymbal's Gland                                     (1)                                                                           
      Squamous Cell Carcinoma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Carcinoma                                        1 (2%)                                                                       
   Urinary Bladder                                    (49)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            23 (46%)     21 (42%)     26 (52%)                                            
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                                      1 (2%)                                                          
      Mesothelioma Benign                                                        1 (2%)                                             
      Mesothelioma Malignant                                        2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05007-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 12:48:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49          48                                                   
     Total Primary Neoplasms                          156         134         167                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          47          47                                                   
     Total Benign Neoplasms                           119          95         120                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              31          31          34                                                   
     Total Malignant Neoplasms                         36          38          46                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       1                                                   
     Total Metastatic Neoplasm                          1                       1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1           1                                                   
     Total Uncertain Neoplasms                          1           1           1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.