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TDMS Study 05019-04 Pathology Tables

NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97
Route: DOSED FEED                                                                                                 Time: 13:19:59




       Facility:  Southern Research Institute

       Chemical CAS #:  2425-85-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Wall, Fibrosarcoma, Metastatic, Skin |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Multiple, Metastatic,  |                                                                          |             
           Three, Skin                     |                                  X                                       |             
      Hemangioma                           |                                                                          |             
      Hepatocellular Carcinoma             |                                        X        X                        |             
      Hepatocellular Adenoma               |                                                    X                     |             
      Lymphoma Malignant Mixed             |    X        X                                   X                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +     +                             +     +  +|             
      Fibrosarcoma, Multiple, Metastatic,  |                                                                          |             
           Greater Than Five, Skin         |                                  X                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Pheochromocytoma Benign              |                                           X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Pars Distalis, Adenoma               | X                       X     X              X                       X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                       X                  |             
      Follicular Cell, Adenoma, Multiple   | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Polyp Stromal                        | X              X                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Iliac, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |    X                                                                     |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Fibrosarcoma,           |                                                                          |             
          Metastatic, Skin                 |                                  X                                       |             
      Mediastinal, Lymphoma Malignant Mixed|                X                                                         |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mesenteric, Lymphoma Malignant Mixed |    X                                                                     |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                X                                                         |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                X                                                         |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |             X                                                            |             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Mixed             |    X           X                       X        X     X  X     X  X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                  X                                       |             
      Subcutaneous Tissue, Osteosarcoma,   |                                                                          |             
           Metastatic, Bone                |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X                                            X     X                     |             
      Alveolar/Bronchiolar Carcinoma       |                                                                X         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                 X                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |             
           Greater Than Five, Bone         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
      Adenoma                              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |             
           Two, Bone                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X        X  X                       X        X     X  X     X  X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 2| 2| 9| 0| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 9| 9| 1| 8| 0| 0| 8| 0| 0| 0| 0| 3| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Wall, Fibrosarcoma, Metastatic, Skin |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                          X              X|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Multiple, Metastatic,  |                                                                          |             
           Three, Skin                     |                                                                          |             
      Hemangioma                           |                                                                         X|             
      Hepatocellular Carcinoma             |                                                 X        X               |             
      Hepatocellular Adenoma               |       X                             X        X     X     X     X         |             
      Lymphoma Malignant Mixed             |             X                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +     +                                      +|             
      Fibrosarcoma, Multiple, Metastatic,  |                                                                          |             
           Greater Than Five, Skin         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 2| 2| 9| 0| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 9| 9| 1| 8| 0| 0| 8| 0| 0| 0| 0| 3| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
      Osteosarcoma, Metastatic, Bone       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |             X                                                            |             
      Pars Distalis, Adenoma               |                                  X     X  X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                  X                                       |             
      Follicular Cell, Adenoma, Multiple   |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |             X                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                         X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                    X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                         X                                                |             
      Iliac, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 2| 2| 9| 0| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 9| 9| 1| 8| 0| 0| 8| 0| 0| 0| 0| 3| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                         X                                                |             
      Lumbar, Lymphoma Malignant Mixed     |             X                                                            |             
      Mediastinal, Fibrosarcoma,           |                                                                          |             
          Metastatic, Skin                 |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|             X                                                           X|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                         X                                                |             
      Mesenteric, Lymphoma Malignant Mixed |          X  X                                            X               |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                         X                                                |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                         X                                                |             
      Renal, Lymphoma Malignant Mixed      |             X                                                            |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |             X                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                    X                     |             
      Lymphoma Malignant Mixed             |          X  X                                            X           X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |             X                                            X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                X                                                         |             
      Subcutaneous Tissue, Osteosarcoma,   |                                                                          |             
           Metastatic, Bone                |                                                       X                  |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 2| 2| 9| 0| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 9| 9| 1| 8| 0| 0| 8| 0| 0| 0| 0| 3| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Mixed             |             X                                                            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |             
           Greater Than Five, Bone         |                                                       X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                   +                              |             
      Adenoma                              |       X                                   X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |             
           Two, Bone                       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X  X                                            X           X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 6| 9| 9| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  48        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  48        |
      Wall, Fibrosarcoma, Metastatic, Skin |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  49        |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Mixed                            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  49        |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Fibrosarcoma, Multiple, Metastatic,  |                                                                          |            |
           Three, Skin                     |                                                                          |          1 |
      Hemangioma                           |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          4 |
      Hepatocellular Adenoma               |                                                                          |          7 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   8        |
      Fibrosarcoma, Multiple, Metastatic,  |                                                                          |            |
           Greater Than Five, Skin         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 6| 9| 9| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Pars Distalis, Adenoma               |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
      Follicular Cell, Adenoma, Multiple   |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 6| 9| 9| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Iliac, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mediastinal, Fibrosarcoma,           |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          3 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          4 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          2 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |         12 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 6| 9| 9| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          2 |
      Subcutaneous Tissue, Osteosarcoma,   |                                                                          |            |
           Metastatic, Bone                |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Osteosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |            |
           Greater Than Five, Bone         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Adenoma                              |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 6| 9| 9| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |            |
           Two, Bone                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |         14 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 6| 7| 6| 6| 7| 5| 6| 5| 7| 5| 7| 5| 7| 2| 6| 5| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 5| 4| 8| 3| 2| 2| 3| 9| 2| 5| 3| 5| 3| 8| 3| 8| 2| 8| 3| 3| 3| 9| 2| 3| 3|             
                                           | 8| 0| 0| 0| 5| 7| 0| 9| 7| 7| 0| 7| 0| 8| 0| 6| 7| 8| 0| 0| 0| 9| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Histiocytic                      |                                                                         X|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                   X  X                    X                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                   X                 X                 X           X     X|             
      Hepatocellular Adenoma, Multiple, Two|                                                                          |             
      Histiocytic Sarcoma                  |       X                                                        X         |             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Mast Cell Tumor Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +                          +                          +      |             
      Fibrous Histiocytoma, Multiple,      |                                                                          |             
          Greater Than Five                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Lymphoma Malignant Mixed     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 6| 7| 6| 6| 7| 5| 6| 5| 7| 5| 7| 5| 7| 2| 6| 5| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 5| 4| 8| 3| 2| 2| 3| 9| 2| 5| 3| 5| 3| 8| 3| 8| 2| 8| 3| 3| 3| 9| 2| 3| 3|             
                                           | 8| 0| 0| 0| 5| 7| 0| 9| 7| 7| 0| 7| 0| 8| 0| 6| 7| 8| 0| 0| 0| 9| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                       X  X           X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma, Papillary               |                                                                          |             
      Histiocytic Sarcoma                  |       X                                                                  |             
      Granulosa Cell, Adenoma              |                               X                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma, Cystic                      |                                  X                                       |             
      Sarcoma                              |             X                                                            |             
      Cervix, Histiocytic Sarcoma          |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                    +                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Histiocytic Sarcoma        | X                                                                        |             
      Deep Cervical, Histiocytic Sarcoma   |                                                                X         |             
      Iliac, Histiocytic Sarcoma           | X     X                                                                  |             
      Inguinal, Fibrosarcoma, Metastatic,  |                                                                          |             
           Skin                            |                                                                          |             
      Inguinal, Histiocytic Sarcoma        | X                                                                        |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                         X|             
      Mediastinal, Fibrous Histiocytoma,   |                                                                          |             
           Metastatic, Mesentery           |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                         X|             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mesenteric, Histiocytic Sarcoma      |                                                                X         |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                         X|             
      Mesenteric, Lymphoma Malignant Mixed |                      X                    X                              |             
      Pancreatic, Lymphoma Malignant Mixed |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 6| 7| 6| 6| 7| 5| 6| 5| 7| 5| 7| 5| 7| 2| 6| 5| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 5| 4| 8| 3| 2| 2| 3| 9| 2| 5| 3| 5| 3| 8| 3| 8| 2| 8| 3| 3| 3| 9| 2| 3| 3|             
                                           | 8| 0| 0| 0| 5| 7| 0| 9| 7| 7| 0| 7| 0| 8| 0| 6| 7| 8| 0| 0| 0| 9| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Histiocytic Sarcoma           | X     X                                                                  |             
      Renal, Lymphoma Malignant Mixed      |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                          |             
      Hemangioma                           |                                           X                              |             
      Histiocytic Sarcoma                  | X                                                              X         |             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                   X                       X                              |             
      Mast Cell Tumor Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Subcutaneous Tissue, Fibroma         |                      X                                                   |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                 X                        |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 6| 7| 6| 6| 7| 5| 6| 5| 7| 5| 7| 5| 7| 2| 6| 5| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 5| 4| 8| 3| 2| 2| 3| 9| 2| 5| 3| 5| 3| 8| 3| 8| 2| 8| 3| 3| 3| 9| 2| 3| 3|             
                                           | 8| 0| 0| 0| 5| 7| 0| 9| 7| 7| 0| 7| 0| 8| 0| 6| 7| 8| 0| 0| 0| 9| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Mast Cell Tumor Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X     X                                                        X         |             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                   X  X                    X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 0| 3| 1| 3| 2| 8| 3| 2| 1| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 6| 0| 0| 7| 0| 3| 0| 7| 0| 5| 0| 0| 5| 8| 7| 0| 0| 5| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Histiocytic                      |                                                                          |             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                            X                                             |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                       X                  |             
      Hepatocellular Carcinoma             |                                     X                                    |             
      Hepatocellular Adenoma               |    X                                                                 X   |             
      Hepatocellular Adenoma, Multiple, Two|                                        X                                 |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Mast Cell Tumor Malignant            |                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +  +                  |             
      Fibrous Histiocytoma, Multiple,      |                                                                          |             
          Greater Than Five                |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |       X                                                                  |             
      Squamous Cell Papilloma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Lymphoma Malignant Mixed     |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 0| 3| 1| 3| 2| 8| 3| 2| 1| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 6| 0| 0| 7| 0| 3| 0| 7| 0| 5| 0| 0| 5| 8| 7| 0| 0| 5| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X        X                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma, Papillary               |                                                    X                     |             
      Histiocytic Sarcoma                  |                                                                          |             
      Granulosa Cell, Adenoma              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma, Cystic                      |                                                                          |             
      Sarcoma                              |                                                                          |             
      Cervix, Histiocytic Sarcoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor Malignant            |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Histiocytic Sarcoma        |                                                                          |             
      Deep Cervical, Histiocytic Sarcoma   |                                                                          |             
      Iliac, Histiocytic Sarcoma           |                                                                          |             
      Inguinal, Fibrosarcoma, Metastatic,  |                                                                          |             
           Skin                            |    X                                                                     |             
      Inguinal, Histiocytic Sarcoma        |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Fibrous Histiocytoma,   |                                                                          |             
           Metastatic, Mesentery           |                                                       X                  |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|             X                                                            |             
      Mesenteric, Histiocytic Sarcoma      |                                                                          |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mesenteric, Lymphoma Malignant Mixed |             X              X     X                                       |             
      Pancreatic, Lymphoma Malignant Mixed |             X                    X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 0| 3| 1| 3| 2| 8| 3| 2| 1| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 6| 0| 0| 7| 0| 3| 0| 7| 0| 5| 0| 0| 5| 8| 7| 0| 0| 5| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                       X                  |             
      Hemangioma                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                            X                                             |             
      Mast Cell Tumor Malignant            |                         X                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Mesentery                       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                 X                 X      |             
      Fibrosarcoma, Metastatic, Skin       |    X                                                                     |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
      Adenoma                              |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 0| 3| 1| 3| 2| 8| 3| 2| 1| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 6| 0| 0| 7| 0| 3| 0| 7| 0| 5| 0| 0| 5| 8| 7| 0| 0| 5| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Mast Cell Tumor Malignant            |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |             X              X     X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 9| 8| 9| 9| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  48        |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Mixed                            |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          7 |
      Hepatocellular Adenoma, Multiple, Two|                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Fibrous Histiocytoma, Multiple,      |                                                                          |            |
          Greater Than Five                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Hemangioma                           |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  49        |
      Serosa, Lymphoma Malignant Mixed     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 9| 8| 9| 9| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Adenoma               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Follicular Cell, Adenoma             |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Cystadenoma, Papillary               |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Granulosa Cell, Adenoma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Adenoma, Cystic                      |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
      Cervix, Histiocytic Sarcoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Axillary, Histiocytic Sarcoma        |                                                                          |          1 |
      Deep Cervical, Histiocytic Sarcoma   |                                                                          |          1 |
      Iliac, Histiocytic Sarcoma           |                                                                          |          2 |
      Inguinal, Fibrosarcoma, Metastatic,  |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Inguinal, Histiocytic Sarcoma        |                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 9| 8| 9| 9| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Fibrous Histiocytoma,   |                                                                          |            |
           Metastatic, Mesentery           |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Mesenteric, Histiocytic Sarcoma      |                                                                          |          1 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          5 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          3 |
      Renal, Histiocytic Sarcoma           |                                                                          |          2 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
      Hemangioma                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 9| 8| 9| 9| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Histiocytic Sarcoma                  |                                                                          |          3 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 7| 9| 3| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 7| 9| 3| 3| 3| 3| 3| 3| 3| 2| 4| 0|             
                                           | 0| 7| 1| 6| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 5| 1| 1| 1| 1| 1| 1| 1| 4| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +     +  +                       +  +  A                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +                       +  A  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +                       +  A  A                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +                       +  A  A                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +                       +  +  +                       +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +                       +  A  A                       +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +                       +  +  +                       +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +                       +  +  +                       +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +                       +  +  +                       +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +                       +  M  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 7| 9| 3| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 7| 9| 3| 3| 3| 3| 3| 3| 3| 2| 4| 0|             
                                           | 0| 7| 1| 6| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 5| 1| 1| 1| 1| 1| 1| 1| 4| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell, Adenoma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Sarcoma                              |                                                                X         |             
      Cervix, Histiocytic Sarcoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                        +                                 |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +     +              +  +  +        +              +  +  +|             
      Axillary, Fibrosarcoma, Metastatic,  |                                                                          |             
           Skin                            |                                                                          |             
      Axillary, Lymphoma Malignant Mixed   |                                     X                                    |             
      Iliac, Lymphoma Malignant Mixed      |                                     X     X                              |             
      Inguinal, Fibrosarcoma, Metastatic,  |                                                                          |             
           Skin                            |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                     X                                    |             
      Mediastinal, Lymphoma Malignant Mixed|                                     X     X                              |             
      Mesenteric, Lymphoma Malignant Mixed |                X                    X     X        X                     |             
      Pancreatic, Lymphoma Malignant Mixed |                                     X  X  X                              |             
      Renal, Lymphoma Malignant Mixed      |                X                    X     X        X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +                       +  +  +                       +  +  +|             
      Lymphoma Malignant Mixed             |                                     X     X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Mixed             |             X                       X              X                     |             
      Capsule, Lymphoma Malignant Mixed    |                                           X                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +                       +  +  +        +              +  +  +|             
      Lymphoma Malignant Mixed             |                                     X              X                     |             
      Mediastinum, Lymphoma Malignant Mixed|                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +        +  +  +  +     +  +  +  +              +  +  +  +  +|             
      Squamous Cell Carcinoma              |          X                                                               |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |             X                                                            |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Benign                           |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 7| 9| 3| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 7| 9| 3| 3| 3| 3| 3| 3| 3| 2| 4| 0|             
                                           | 0| 7| 1| 6| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 5| 1| 1| 1| 1| 1| 1| 1| 4| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +                       +  +  +                       +  +  +|             
      Osteosarcoma                         |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +                       +  +  +                       +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +        +           +  +  +                       +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                         X                                                |             
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |             
           Greater Than Five, Bone         |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +                       +  +  +                       +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +                       +  +  +                       +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |             X  X                    X  X  X        X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 1| 6| 2| 3| 2| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4|             
                                           | 1| 6| 1| 1| 1| 1| 2| 6| 2| 2| 6| 8| 4| 2| 7| 2| 2| 7| 2| 5| 2| 3| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +              +  +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +              +  +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +              +  +        +  +  +     +        A           +        +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +              +  +        +  +  +     +        A           +        +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             | X                                      X                                 |             
      Hepatocellular Adenoma               |                                                                   X  X   |             
      Histiocytic Sarcoma                  |                                  X        X                              |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                        +               |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +                 +        +  +  +     +        A     +     +        +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +           +  +     +  +  +     +  +  +  A        +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +           +  +     +  +  +     +  +  +  A        +  +  +     +|             
      Squamous Cell Papilloma              |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +                 +        +  +  +     +        A           +        +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +                 +        +  +  +     +        +           +        +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +                 +        +  M  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 1| 6| 2| 3| 2| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4|             
                                           | 1| 6| 1| 1| 1| 1| 2| 6| 2| 2| 6| 8| 4| 2| 7| 2| 2| 7| 2| 5| 2| 3| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell, Adenoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  A  +        +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X                                       |             
      Sarcoma                              |                                                                          |             
      Cervix, Histiocytic Sarcoma          |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +              +  +        +  +  +     +        A     +     +        +|             
      Axillary, Fibrosarcoma, Metastatic,  |                                                                          |             
           Skin                            |                                     X                                    |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                   X                                                      |             
      Inguinal, Fibrosarcoma, Metastatic,  |                                                                          |             
           Skin                            |                                     X                                    |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mesenteric, Lymphoma Malignant Mixed |                   X                                                      |             
      Pancreatic, Lymphoma Malignant Mixed |                   X                                                      |             
      Renal, Lymphoma Malignant Mixed      |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +                 +        +  +  +     +        A           +        +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                X                                                     X   |             
      Lymphoma Malignant Mixed             |          X        X                                                      |             
      Capsule, Lymphoma Malignant Mixed    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +                 +        +  +  +     +        A           +        +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mediastinum, Lymphoma Malignant Mixed|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +                 +        +  +  +     +        +           +        +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +        +  +  +  +        +  +  +     +        +  +  +  +  +  +     +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                     X                                    |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Benign                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 1| 6| 2| 3| 2| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4|             
                                           | 1| 6| 1| 1| 1| 1| 2| 6| 2| 2| 6| 8| 4| 2| 7| 2| 2| 7| 2| 5| 2| 3| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +                 +        +  +  +     +        +           +        +|             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +                 +        +  +  +     +        A           +        +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +                 +        +  +  +     +        +           +        +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |             
           Greater Than Five, Bone         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +                 +        +  +  +     +        +           +        +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +                 +        +  +  +     +        A           +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
      Adenoma                              |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +                 +        +  +  +     +        A           +        +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                  X        X                              |             
      Lymphoma Malignant Mixed             |          X        X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 8| 9| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  19        |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  17        |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  49        |
      Hepatocellular Carcinoma             |                                                                          |          2 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  24        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  24        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  18        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  19        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 8| 9| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Granulosa Cell, Adenoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  43        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
      Cervix, Histiocytic Sarcoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  23        |
      Axillary, Fibrosarcoma, Metastatic,  |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          3 |
      Inguinal, Fibrosarcoma, Metastatic,  |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          5 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          4 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  18        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          5 |
      Capsule, Lymphoma Malignant Mixed    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  19        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Mediastinum, Lymphoma Malignant Mixed|                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  33        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  34                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 8| 9| 9| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Benign                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  19        |
      Osteosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  18        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  21        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Osteosarcoma, Multiple, Metastatic,  |                                                                          |            |
           Greater Than Five, Bone         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  18        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  18        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 5| 6| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 5| 9| 3| 3| 3| 6|             
                                           | 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 2| 8| 3| 6| 2| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +                             +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +  +                             +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +                             +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +                             +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +                             +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +                             +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +                    +        +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +                    +        +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +                    +        +     A        +  +  +           +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +                    +        +     A        +  +  +           +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |    X           X              X                                          |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
           Two                             |                                        X                                 |             
      Hepatocellular Adenoma               |    X                                X  X                 X               |             
      Histiocytic Sarcoma                  |          X                                            X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                   +        +            |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +                             +     A        +  +  +           +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +                             +     +        +  +  +           +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +                             +  +  A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +                             +  +  A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +                             +     A        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +                             +     +        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +                             +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +                             +     +        +  +  +           +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +                             +     +        +  +  +           +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +                             +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +                             +     +        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 5| 6| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 5| 9| 3| 3| 3| 6|             
                                           | 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 2| 8| 3| 6| 2| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +           +        +        +     A        +  +  +           +|             
      Pars Distalis, Adenoma               |                      X        X                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             | X                                                                        |             
      Follicular Cell, Carcinoma           |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +     +     +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |          X                                                               |             
      Polyp Stromal                        |                                  X                                       |             
      Sarcoma                              |                                                                         X|             
      Cervix, Histiocytic Sarcoma          |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +                    +     +  +     +        +  +  +           +|             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|       X                                                                  |             
      Mesenteric, Lymphoma Malignant Mixed |       X                       X                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +                             +     +        +  +  +           +|             
      Lymphoma Malignant Mixed             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |    X                                                                     |             
      Lymphoma Malignant Mixed             |       X                       X                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +                             +     +        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +                    +        +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +        +     +  +     +  +  +           +|             
      Subcutaneous Tissue, Hemangioma      | X                                                                        |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 5| 6| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 5| 9| 3| 3| 3| 6|             
                                           | 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 2| 8| 3| 6| 2| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +                             +     +        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +                    +        +     +        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +                             +     +        +  +  +           +|             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
           Metastatic, Greater Than Five,  |                                                                          |             
           Liver                           |                                        X                                 |             
      Histiocytic Sarcoma                  |                                                       X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +                             +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +                             +     +        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
      Adenoma                              |          X                                                               |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                       X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +                             +     A        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |          X                                            X                  |             
      Lymphoma Malignant Mixed             |       X                       X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 5| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 9| 2| 3| 5| 9| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +     +  +                                +                     |             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +     +  +                                +                     |             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                      X                                                   |             
      Hepatocellular Carcinoma             |          X                                                  X           X|             
      Hepatocellular Carcinoma, Multiple   |                                                       X                  |             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
           Two                             |                                                                          |             
      Hepatocellular Adenoma               | X           X     X        X                                             |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                X                       X                                X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +     +  +                                +                     |             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +     +  +                                +                     |             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +     +  +              +     +           +  +                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +     +  +              +     +           +  +                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +     +  +              +                 +                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +     +  +              +                 +                     |             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +     +  +              +                 +                     |             
      Pheochromocytoma Malignant           |                                  X                                       |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 5| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 9| 2| 3| 5| 9| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +     +  +                                +                     |             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +        +  +     +        +  +  +        +  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Polyp Stromal                        |                                                                          |             
      Sarcoma                              |                                                                          |             
      Cervix, Histiocytic Sarcoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +  +                    +           +        +           +|             
      Axillary, Lymphoma Malignant Mixed   |                                                                         X|             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                X                                                         |             
      Iliac, Lymphoma Malignant Mixed      |                                                                         X|             
      Mediastinal, Lymphoma Malignant Mixed|                X                       X                                X|             
      Mesenteric, Lymphoma Malignant Mixed |             X  X                       X                                X|             
      Pancreatic, Lymphoma Malignant Mixed |                X                                                        X|             
      Renal, Lymphoma Malignant Mixed      |                                        X                                X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +     +  +                                +                    +|             
      Lymphoma Malignant Mixed             |                X                                                        X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                      X                                                   |             
      Lymphoma Malignant Mixed             |             X  X        X              X              X                 X|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +     +  +  +  +              +           +     +  +     +  +   |             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 5| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 9| 2| 3| 5| 9| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +     +  +                                +                     |             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
           Metastatic, Greater Than Five,  |                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                         +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                      X                 X                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |             X  X     X  X              X              X                 X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 8| 9| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  13        |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  13        |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          6 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Carcinoma, Multiple,  |                                                                          |            |
           Two                             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          8 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  12        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  13        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  13        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  15        |
      Adenoma                              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 8| 9| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  14        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  14        |
      Pars Distalis, Adenoma               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  49        |
      Cystadenoma                          |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  38        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
      Cervix, Histiocytic Sarcoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  20        |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          4 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          6 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          2 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  15        |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Hemangiosarcoma                      |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 8| 9| 8| 8| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  13        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  29        |
      Subcutaneous Tissue, Hemangioma      |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  13        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  14        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  13        |
      Hepatocellular Carcinoma, Multiple,  |                                                                          |            |
           Metastatic, Greater Than Five,  |                                                                          |            |
           Liver                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  13        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  49        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  12        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          9 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 1| 2| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 9| 8| 5| 2| 2| 2| 2| 2| 8| 3| 2| 5| 2| 5| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 9| 9| 9| 1| 0| 9| 9| 9| 9| 9| 0| 0| 9| 3| 9| 1| 0| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |             X                                                            |             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
           Three                           |                                           X                              |             
      Hepatocellular Adenoma               |             X                                X                       X   |             
      Hepatocellular Adenoma, Multiple, Two|                                                                X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +                 +     +  +        +     +                    +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +                          +           +                          +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 1| 2| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 9| 8| 5| 2| 2| 2| 2| 2| 8| 3| 2| 5| 2| 5| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 9| 9| 9| 1| 0| 9| 9| 9| 9| 9| 0| 0| 9| 3| 9| 1| 0| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                +                                                         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Lymphoma Malignant Mixed |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                        X                          X      |             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    | X                                   X  X              X                  |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
           Metastatic, Greater Than Five,  |                                                                          |             
           Liver                           |                                           X                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 1| 2| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 9| 8| 5| 2| 2| 2| 2| 2| 8| 3| 2| 5| 2| 5| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 9| 9| 9| 1| 0| 9| 9| 9| 9| 9| 0| 0| 9| 3| 9| 1| 0| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                    +                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 2| 8| 2| 8| 2| 3| 9| 2| 1| 2| 2| 3| 2| 8| 3| 3| 0| 3| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 9| 9| 3| 9| 0| 1| 9| 6| 9| 4| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |          X                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |       X                                            X  X                  |             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
           Three                           |                                                                          |             
      Hepatocellular Adenoma               |          X                                   X  X                        |             
      Hepatocellular Adenoma, Multiple, Two|                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +           +                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |       +     +                    +     +  +  +                 +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +           +                    +                 +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 2| 8| 2| 8| 2| 3| 9| 2| 1| 2| 2| 3| 2| 8| 3| 3| 0| 3| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 9| 9| 3| 9| 0| 1| 9| 6| 9| 4| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Lymphoma Malignant Mixed |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                             X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                         X                             X                  |             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |          X                                                               |             
      Subcutaneous Tissue, Fibrosarcoma    |             X        X  X                 X     X  X        X            |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X     X                                                                  |             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
           Metastatic, Greater Than Five,  |                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 2| 8| 2| 8| 2| 3| 9| 2| 1| 2| 2| 3| 2| 8| 3| 3| 0| 3| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 9| 9| 3| 9| 0| 1| 9| 6| 9| 4| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  46        |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hepatocellular Carcinoma             |                                                                          |          4 |
      Hepatocellular Carcinoma, Multiple,  |                                                                          |            |
           Three                           |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          6 |
      Hepatocellular Adenoma, Multiple, Two|                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  16        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  46        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  49        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          4 |
      Subcutaneous Tissue, Fibroma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |         11 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Hepatocellular Carcinoma, Multiple,  |                                                                          |            |
           Metastatic, Greater Than Five,  |                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Adenoma                              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 5| 7| 3| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 5|             
                             DAY ON TEST   | 8| 7| 3| 5| 3| 0| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 5|             
                                           | 9| 8| 0| 7| 0| 1| 6| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                        X                                 |             
      Hepatocellular Adenoma               |          X           X  X  X        X  X           X  X           X      |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Hepatocellular Adenoma, Multiple, Two|                                           X                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |       +     +           +     +     +  +  +  +  +  +     +        +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                            X                                      X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 5| 7| 3| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 5|             
                             DAY ON TEST   | 8| 7| 3| 5| 3| 0| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 5|             
                                           | 9| 8| 0| 7| 0| 1| 6| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |          M                                                               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                   +                       +  +                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
      Axillary, Lymphoma Malignant Mixed   |                         X                                                |             
      Iliac, Lymphoma Malignant Histiocytic|                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                         X                                                |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|    X                                                                     |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mesenteric, Lymphoma Malignant Mixed |    X                          X                    X                     |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X                                X              X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |       X                                                                  |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 5| 7| 3| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 5|             
                             DAY ON TEST   | 8| 7| 3| 5| 3| 0| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 5|             
                                           | 9| 8| 0| 7| 0| 1| 6| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X                 X                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Adenoma                      |                                              X     X                     |             
      Cortex, Adenoma, Multiple            |                            X                                             |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                    X     X     X              X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 5|             
                                           | 1| 1| 0| 1| 1| 1| 5| 1| 1| 4| 1| 7| 1| 1| 1| 1| 5| 5| 1| 1| 1| 4| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |    X                          X                                         X|             
      Hepatocellular Adenoma               |                X                    X  X              X                  |             
      Hepatocellular Adenoma, Multiple     |          X                                X                              |             
      Hepatocellular Adenoma, Multiple, Two|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +        +  +              +     +  +     +     +     +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                      X                                            X     X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 5|             
                                           | 1| 1| 0| 1| 1| 1| 5| 1| 1| 4| 1| 7| 1| 1| 1| 1| 5| 5| 1| 1| 1| 4| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                             +            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +                             +         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                   X                                                      |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Iliac, Lymphoma Malignant Histiocytic|                   X                                                      |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                   X                                                      |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                   X                                                      |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                   X                                                      |             
      Mesenteric, Lymphoma Malignant Mixed |                                                    X                     |             
      Pancreatic, Lymphoma Malignant Mixed |                                                    X                     |             
      Renal, Lymphoma Malignant Histiocytic|                   X                                                      |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                           X                              |             
      Subcutaneous Tissue, Fibrosarcoma    |                                  X                       X     X         |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 5|             
                                           | 1| 1| 0| 1| 1| 1| 5| 1| 1| 4| 1| 7| 1| 1| 1| 1| 5| 5| 1| 1| 1| 4| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X                             X  X                                       |             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
      Adenoma                              |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Adenoma                      | X  X                                         X                           |             
      Cortex, Adenoma, Multiple            |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                           +     +                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 4| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 5| 5| 3| 5| 5| 5| 5|                                            |            |
                                           | 4| 7| 7| 6| 6| 1| 7| 6| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  45        |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  44        |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  46        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  49        |
      Hepatocellular Carcinoma             |                                                                          |          4 |
      Hepatocellular Adenoma               |                                                                          |         13 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          2 |
      Hepatocellular Adenoma, Multiple, Two|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  24        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 4| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 5| 5| 3| 5| 5| 5| 5|                                            |            |
                                           | 4| 7| 7| 6| 6| 1| 7| 6| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Adenoma             |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Iliac, Lymphoma Malignant Histiocytic|                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          4 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Lymphoma Malignant Histiocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 4| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 5| 5| 3| 5| 5| 5| 5|                                            |            |
                                           | 4| 7| 7| 6| 6| 1| 7| 6| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  45        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          4 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |                                                                          |          1 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Neurofibrosarcoma                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          5 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Cortex, Adenoma                      |                                                                          |          5 |
      Cortex, Adenoma, Multiple            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 4| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 5| 5| 3| 5| 5| 5| 5|                                            |            |
                                           | 4| 7| 7| 6| 6| 1| 7| 6| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  63                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 3| 5| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 6| 5| 7| 2| 6| 3| 3| 3| 3| 3| 3| 3| 7| 2| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 1| 2| 8| 2| 1| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 1| 3| 1| 2| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +        +  +  +  +  A                       A  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  A  +  +  +                       A  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  A  +  +  A                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +  +  A                       A  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +  +  +  +                 +     A  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +  +  A                 +     A  +     +                  |             
      Polyp Adenomatous                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  A  +  +  +                       A  +     +                  |             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  A  +  +  A                       A  +     +                  |             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                         X  X        X           X                        |             
      Hepatocellular Adenoma               | X     X                 X  X              X     X                        |             
      Hepatocellular Adenoma, Multiple     |                   X                                                      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +  +  +  +                       +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +  +  +  +  +                       +  +     +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +  +  +  +  +                       +  +     +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  M  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +  +  +                       +  +     +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 3| 5| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 6| 5| 7| 2| 6| 3| 3| 3| 3| 3| 3| 3| 7| 2| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 1| 2| 8| 2| 1| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 1| 3| 1| 2| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Adenoma             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +        +  +  +  +  +                       +  +     +                  |             
      Fibrosarcoma, Metastatic, Skin       | X                                                                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                         +     +        +                 +  +            |             
                                            __________________________________________________________________________|             
   Prostate                                | +        +  +  +  +  +                       +  +     +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +        +  +  +  +  +                       +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +  +  +                       +  +     +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +  +  +           +           +  +  +  +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Axillary, Fibrosarcoma, Metastatic,  |                                                                          |             
           Skin                            |                                                       X                  |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mesenteric, Lymphoma Malignant Mixed |                                  X                                       |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  +  M  +  M                       +  +     +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +  +  +  +  +                       +  +     +                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M        M  M  +  M  M                       M  M     M                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                            X                                             |             
      Subcutaneous Tissue, Fibrosarcoma    | X  X     X                          X           X     X                  |             
      Subcutaneous Tissue,                 |                                                                          |             
          Rhabdomyosarcoma, Metastatic,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 3| 5| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 6| 5| 7| 2| 6| 3| 3| 3| 3| 3| 3| 3| 7| 2| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 1| 2| 8| 2| 1| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 1| 3| 1| 2| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Skeletal Muscle                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Rhabdomyosarcoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +  +  +                       +  +     +                  |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +  +  +              +     +  +  +     +                 +|             
      Alveolar/Bronchiolar Adenoma         |                                           X     X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +  +  +  +                       +  +     +                  |             
      Sarcoma                              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +  +  +  +                       +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
      Adenoma                              |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |             +                                                            |             
      Transitional Epithelium, Carcinoma   |             X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +  +  +  +                       +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 4| 3| 3| 5| 4| 2| 3| 3| 2| 3| 3| 3| 8| 9| 3| 3| 3| 3| 7| 3| 9|             
                                           | 2| 6| 2| 0| 1| 2| 2| 3| 2| 9| 2| 2| 1| 2| 2| 2| 5| 7| 2| 2| 2| 2| 0| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +     A  +        +  +           +           A  +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     A  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     A  +        +  +           +           A  +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     A  +        +  +           +           A  +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     A  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     A  +        +  +     +     +           A  +        +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     A  +        +  +           +           A  +              +     +|             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     A  +        +  +     +     +           A  +              +     +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     A  A        +  +           +           A  +        +     +     +|             
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |             
          Mixed                            |                                                             X            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                X         |             
      Hepatocellular Carcinoma             |       X                                   X  X           X               |             
      Hepatocellular Adenoma               |                         X              X                       X         |             
      Hepatocellular Adenoma, Multiple     |                                                                      X   |             
      Histiocytic Sarcoma                  |                                                                   X      |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +  +                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     A  +        +  +           +           A  +     +        +     +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  A  +        +  +           +     +     +  +     +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  A  +        +  +           +     +     +  +     +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     A  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                 +  +                          +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +        +  +           +           +  +              +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +  +        +  +           +           +  +              +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +  +        +  +           M           +  +              +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     A  +        +  +           +           A  +              +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +  +        +  +           M           M  +              +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +        +  +           +           M  +              +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 4| 3| 3| 5| 4| 2| 3| 3| 2| 3| 3| 3| 8| 9| 3| 3| 3| 3| 7| 3| 9|             
                                           | 2| 6| 2| 0| 1| 2| 2| 3| 2| 9| 2| 2| 1| 2| 2| 2| 5| 7| 2| 2| 2| 2| 0| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +     +  +        +  +           +           +  +              +     +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +  +                                 |             
                                            __________________________________________________________________________|             
   Prostate                                |    +     A  +  +     +  +           +           +  +              +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +     +  +        +  +           +           A  +              +     +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +     +  +        +  +           +           +  +              +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +        +  +           +           +  +              +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +     +  +  +  +     +           +  +        +     +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Axillary, Fibrosarcoma, Metastatic,  |                                                                          |             
           Skin                            |                                                                          |             
      Axillary, Lymphoma Malignant Mixed   |    X                                                                     |             
      Iliac, Lymphoma Malignant Mixed      |    X           X              X                                          |             
      Inguinal, Lymphoma Malignant Mixed   |    X                                                                     |             
      Mediastinal, Lymphoma Malignant Mixed|    X                                                                     |             
      Mesenteric, Lymphoma Malignant Mixed |    X           X           X  X                             X            |             
      Pancreatic, Lymphoma Malignant Mixed |    X                          X                                          |             
      Renal, Lymphoma Malignant Mixed      |    X           X              X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +  +        +  +           +           +  +              +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                X         |             
      Lymphoma Malignant Mixed             |    X           X              X                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +        +  +           +           +  +              +     +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M     M  M        M  M           M           M  M              M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                            X                          X                  |             
      Subcutaneous Tissue, Fibrosarcoma    |             X                                         X                  |             
      Subcutaneous Tissue,                 |                                                                          |             
          Rhabdomyosarcoma, Metastatic,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 4| 3| 3| 5| 4| 2| 3| 3| 2| 3| 3| 3| 8| 9| 3| 3| 3| 3| 7| 3| 9|             
                                           | 2| 6| 2| 0| 1| 2| 2| 3| 2| 9| 2| 2| 1| 2| 2| 2| 5| 7| 2| 2| 2| 2| 0| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Skeletal Muscle                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
      Rhabdomyosarcoma                     |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +        +  +           +           +  +              +     +|             
      Histiocytic Sarcoma                  |                      X                                                   |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +           +     +     +  +              +     +|             
      Alveolar/Bronchiolar Adenoma         | X     X     X     X                       X                              |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +  +  +     +  +           +           +  +              +     +|             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +        +  +           +           +  +              +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Urethra                                 |             +           +                                                |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     A  +        +  +           +           +  +              +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                      X                                            X      |             
      Lymphoma Malignant Mixed             |    X           X           X  X                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 6| 6| 6| 7| 6| 7| 6| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  16        |
      Polyp Adenomatous                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  16        |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  14        |
      Lymphoid Tissue, Lymphoma Malignant  |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          8 |
      Hepatocellular Adenoma               |                                                                          |          9 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  19        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  19        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  18        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 6| 6| 6| 7| 6| 7| 6| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  18        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  19        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  19        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  19        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  19        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  26        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Axillary, Fibrosarcoma, Metastatic,  |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          3 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          6 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          2 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  17        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 6| 6| 6| 7| 6| 7| 6| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  19        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  45        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          3 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          8 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Rhabdomyosarcoma, Metastatic,    |                                                                          |            |
           Skeletal Muscle                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Rhabdomyosarcoma                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  19        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  26        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  20        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  19        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   3        |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  18        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  72                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 6| 6| 6| 7| 6| 7| 6| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  73                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 3| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 2| 2| 7| 7| 1| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 1| 2| 3| 3| 3| 3| 3| 2| 7| 3| 0| 3| 0| 3| 5| 2| 8| 3| 3| 8| 9| 3| 3| 7|             
                                           | 2| 6| 2| 2| 2| 2| 6| 2| 9| 9| 2| 3| 5| 4| 5| 3| 8| 3| 5| 5| 0| 5| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  M           A        +     +     +     +  A  M        M  M        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +           +        +     +     +     +  A  +        +  A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +           A        +     +     +     +  A  +        +  A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +           +        +     +     +     +  A  +        +  A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +           +        +     +     +     +  A  +        +  A        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +           +        +     +     +     +  A  +        +  A        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +           A        +     +     +     +  A  +        +           M|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +           +        +     +     +     M  A  +        +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +           +        +     +     +     +  A  +        +           +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |                               X              X           X        X      |             
      Hepatocellular Carcinoma, Multiple   |                                  X                                       |             
      Hepatocellular Adenoma               |          X     X     X           X           X           X               |             
      Hepatocellular Adenoma, Multiple, Two|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +           +        +     +     +     +  +  +        +  A        +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +           A        +     +     +     +  +  +  +     +  A        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +           A        +     +     +     +  +  +  +     +  A        +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +           A        +     +     +     +  +  +  +     +  A        +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +                                             |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +           +        +     +     +     +  +  +        +  +        +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +           +        +  +  +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +           +        +  +  +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +           +        +     +     +     +  +  +        +  +        +|             
      Pheochromocytoma Malignant           |                                                                         X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +           +        +     +     +     +  +  M        M  M        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  I           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +           +        +     +     +     +  +  +        +  +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 3| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 2| 2| 7| 7| 1| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 1| 2| 3| 3| 3| 3| 3| 2| 7| 3| 0| 3| 0| 3| 5| 2| 8| 3| 3| 8| 9| 3| 3| 7|             
                                           | 2| 6| 2| 2| 2| 2| 6| 2| 9| 9| 2| 3| 5| 4| 5| 3| 8| 3| 5| 5| 0| 5| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                         +                 +         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +  +  +  +     +     +     +        +           +               |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +           +        +     +     +     +  +  +        +  +        +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +        +     +  +     +     +     +  +  +     +  +  +        +|             
      Lymphoma Malignant Mixed             |          X                                                               |             
      Axillary, Lymphoma Malignant Mixed   |                         X                                                |             
      Iliac, Lymphoma Malignant Mixed      |                         X                                                |             
      Inguinal, Lymphoma Malignant Mixed   |                         X                                                |             
      Mediastinal, Hepatocellular          |                                                                          |             
          Carcinoma, Metastatic, Liver     |                                  X                                       |             
      Mesenteric, Lymphoma Malignant Mixed |                         X                                                |             
      Renal, Lymphoma Malignant Mixed      |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  M           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A|             
      Lymphoma Malignant Mixed             |          X              X                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +           +        +     M     +     +  +  +        +  M        +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M           M        M     M     M     M  M  M        M  M        M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Subcutaneous Tissue, Fibroma         |                         X                                                |             
      Subcutaneous Tissue, Fibrosarcoma    |                      X  X              X                                 |             
      Subcutaneous Tissue, Neurofibroma    |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +           +        +     +     +     +  +  +        +  +        +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +           +        +     +     +     +  +  +        +  +        +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +           +        +     +     +     +  +  +        +  +        +|             
      Alveolar/Bronchiolar Adenoma         | X                                            X                           |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 3| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 2| 2| 7| 7| 1| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 1| 2| 3| 3| 3| 3| 3| 2| 7| 3| 0| 3| 0| 3| 5| 2| 8| 3| 3| 8| 9| 3| 3| 7|             
                                           | 2| 6| 2| 2| 2| 2| 6| 2| 9| 9| 2| 3| 5| 4| 5| 3| 8| 3| 5| 5| 0| 5| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Metastatic, Greater Than Five,  |                                                                          |             
           Liver                           |                                  X                                       |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +           +        +     +     +     +  +  +        +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +  +     +                              |             
      Adenoma                              |                                  X  X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                    +                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +           +        +     +     +  +  +  +  +        +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X              X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 3| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 1| 8| 0| 4| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 8| 3| 2| 8| 3| 3|             
                                           | 0| 5| 5| 5| 2| 8| 2| 8| 0| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| 9| 8| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +           +  +  +  +  +  +                       +     +        +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +           +  +  +  +  +  +                       M     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      | X                                                                        |             
      Hepatocellular Carcinoma             |                         X        X     X                                 |             
      Hepatocellular Carcinoma, Multiple   |             X                                                           X|             
      Hepatocellular Adenoma               |                         X     X        X                       X        X|             
      Hepatocellular Adenoma, Multiple, Two|                                                       X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                   +               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +  +  +  +  +  +                       +     +        +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +           +  +  +  +  +  +                       A     +     +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +           +  +  +  +  +  +                       A     +     +  +      |             
      Squamous Cell Papilloma              |                                                                X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +           +  +  +  +  +  +                       +     +        +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +           +  +  +  +  +  +                       +     +        +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +           +  +  +  +  +  +                       +     +        +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +           +  +  +  +  +  +                       M     +        +      |             
      Pheochromocytoma Malignant           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +  +  +  +  +  +                       +     +        +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +           +  +  +  +  +  +                       +     +        +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +  +  +  +  +  +                       M     +        +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +           +  +  +  +  +  +                       +     +        +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 3| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 1| 8| 0| 4| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 8| 3| 2| 8| 3| 3|             
                                           | 0| 5| 5| 5| 2| 8| 2| 8| 0| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| 9| 8| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +        +                 +        +           +                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +           +  +  +  +  +  +                       +     +        +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +           +  +  +  +  +  +                       +     +        +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                   +      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +           +  +  +  +  +  +                       +     +        +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +  +  +  +  +  +  +                    +     +     +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Mediastinal, Hepatocellular          |                                                                          |             
          Carcinoma, Metastatic, Liver     |                                                                          |             
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +           M  +  +  +  +  +                       M     +        M      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M           +  +  +  +  +  +                       M     +        +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M           M  M  M  M  M  M                       M     M        M      |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +        +              +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |          X           X     X                                   X         |             
      Subcutaneous Tissue, Neurofibroma    |                                                                      X   |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                   X  X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +           +  +  +  +  +  +                       +     +        +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +           +  +  +  +  +  +                       +     +        +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +  +  +  +  +                       +  +  +        +      |             
      Alveolar/Bronchiolar Adenoma         | X                       X                             X                  |             
      Alveolar/Bronchiolar Carcinoma       | X                                                     X                  |             
      Fibrosarcoma, Metastatic, Skin       |                            X                                             |             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 3| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 1| 8| 0| 4| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 8| 3| 2| 8| 3| 3|             
                                           | 0| 5| 5| 5| 2| 8| 2| 8| 0| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| 9| 8| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Metastatic, Greater Than Five,  |                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +           +  +  +  +  +  +                       +     +        +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +  +  +  +  +  +                       A     +        +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 6| 7| 6| 7| 7| 6| 7| 7| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  48        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          7 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          3 |
      Hepatocellular Adenoma               |                                                                          |         11 |
      Hepatocellular Adenoma, Multiple, Two|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  21        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  21        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  22        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  21        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  80                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 6| 7| 6| 7| 7| 6| 7| 7| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  21        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  22        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  27        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Mediastinal, Hepatocellular          |                                                                          |            |
          Carcinoma, Metastatic, Liver     |                                                                          |          1 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  47        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  18        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  39        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          7 |
      Subcutaneous Tissue, Neurofibroma    |                                                                          |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  22        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  22        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  81                                                               
NTP Experiment-Test: 05019-04                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 13:19:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 6| 7| 6| 7| 7| 6| 7| 7| 6|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  25        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          5 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Hepatocellular Carcinoma, Multiple,  |                                                                          |            |
           Metastatic, Greater Than Five,  |                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  21        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  22        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Adenoma                              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  22        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  82                                                               
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                                  ----------              END OF REPORT             ----------                                      
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