National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2772

TDMS Study 05019-04 Pathology Tables

NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97
Route: DOSED FEED                                                                                                 Time: 06:45:26




       Facility:  Southern Research Institute

       Chemical CAS #:  2425-85-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                                |             
      Basophilic Focus                     |                                                                          |             
      Cytologic Alterations                |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                    1                     |             
      Inflammation, Granulomatous          |                                                                          |             
      Necrosis, Focal                      |                      1                                   1           1   |             
      Necrosis, Multifocal                 |                                                                          |             
      Kupffer Cell, Pigmentation           |                                                    2                     |             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                            1     2                                      3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +     +                             +     +  +|             
      Inflammation, Acute, Suppurative     |                            3                                            2|             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                3     3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                                          |             
      Inflammation, Acute, Suppurative     |                            3                                             |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Acinus, Atrophy, Multifocal          |                                  3                                       |             
      Acinus, Necrosis, Multifocal         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              | 3                       2                             2                  |             
      Hyperplasia                          | 2                 2     2                             2  1     1     1   |             
      Hypertrophy                          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Multiple                    |                                                                         2|             
      Hemorrhage                           |                                                                         2|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
      Dysplasia                            |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Subacute       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                             2            |             
      Hypertrophy, Diffuse                 |                                                                          |             
      Hypertrophy, Focal                   |          2                                                               |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                  2                                       |             
      X-Zone, Degeneration, Fatty          | 4                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3                       3     2     1     2  3                       2   |             
      Pars Distalis, Cyst                  |       2                                                                  |             
      Pars Distalis, Hyperplasia           |    2  2  2  2  1                 2  2     2           2           1      |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                         X|             
      Follicle, Cyst                       |                               1                                         2|             
      Follicular Cell, Hyperplasia         | 4                       1     1           1  1              1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Multiple                    |                            4                                            4|             
      Angiectasis                          |                                                                          |             
      Cyst                                 | 2  4     3                    4                    4           2        2|             
      Hemorrhage                           |                               2                                          |             
      Hyperplasia, Cystic                  |                   2                                            2         |             
      Inflammation, Chronic                |                                  2                                       |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                                          2               |             
      Inflammation, Acute, Suppurative     |                            2                                             |             
      Endometrium, Hyperplasia, Cystic     | 1  3  3  3  4  3  2  4  4  3  3  1  3  3  3  2  3  4  4  3  3  4  4  4  1|             
      Endometrium, Hyperplasia             |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Infiltration Cellular, Lipocyte      |       3                                                                  |             
      Myeloid Cell, Hypercellularity       |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Hyperplasia, Lymphoid |                         4                                                |             
      Iliac, Hyperplasia, Lymphoid         |                            4                                             |             
      Mediastinal, Abscess                 |                                                                         2|             
      Mediastinal, Hyperplasia, Lymphoid   |                            4     2                                      3|             
      Mesenteric, Angiectasis              | 1                                            2                           |             
      Mesenteric, Hyperplasia, Lymphoid    | 2                          2     2        2                              |             
      Pancreatic, Hyperplasia, Lymphoid    |                            3                                             |             
      Renal, Hyperplasia, Lymphoid         |                            4                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     | 1                          4  2  4     2           2           2  2     3|             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 1                                                                        |             
      Hemorrhage                           |                                                                          |             
      Mineralization, Multifocal           |    1  2  2     1  1  1  1  2  2  2  2  1     1     2  2     2  2  1  2  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8|             
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1     1     1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1        1|             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Fibrosis, Focal              |                                                                          |             
      Cortex, Metaplasia, Focal, Osseous   |                                                       2                  |             
      Renal Tubule, Dilatation, Multifocal | 3                                                                        |             
      Renal Tubule, Necrosis, Multifocal   |                                                                         3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 2| 2| 9| 0| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 9| 9| 1| 8| 0| 0| 8| 0| 0| 0| 0| 3| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                      X   |             
      Cytologic Alterations                |                                                 1                        |             
      Hematopoietic Cell Proliferation     |                                                       1                  |             
      Inflammation, Granulomatous          |                                                 1                        |             
      Necrosis, Focal                      |                                  1                                       |             
      Necrosis, Multifocal                 |          4                          1                                    |             
      Kupffer Cell, Pigmentation           |                                                 2                        |             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                                       2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +     +                                      +|             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Inflammation, Chronic                |                                                                         4|             
      Fat, Necrosis, Focal                 |                            2     2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                            4                                             |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Inflammation, Chronic                |                                                                         4|             
      Inflammation, Subacute               |                            4              2                              |             
      Acinus, Atrophy, Multifocal          |                            4              2                              |             
      Acinus, Necrosis, Multifocal         |                            4                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                        2     2  2                        |             
      Hyperplasia                          |                               2        2     2  2                        |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Multiple                    |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 2| 2| 9| 0| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 9| 9| 1| 8| 0| 0| 8| 0| 0| 0| 0| 3| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Subacute       |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   1      |             
      Hyperplasia, Focal                   |                                                                         2|             
      Hyperplasia, Multifocal              |                                                                          |             
      Hypertrophy, Diffuse                 |                                  2                                       |             
      Hypertrophy, Focal                   |                                                                         1|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                          |             
      X-Zone, Degeneration, Fatty          |                                           1                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                              2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                  2     3  2                              |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       2                             2        1           2  2     2      |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicle, Cyst                       |                               1        1                    1     1     2|             
      Follicular Cell, Hyperplasia         |                               1  2     4                    1     1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Multiple                    |                                                                          |             
      Angiectasis                          |                                                    2                     |             
      Cyst                                 |       3     3  2  2  2              2        3  X     3     2  4         |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic                |                                                                         4|             
      Pigmentation, Hemosiderin            |             2                                                            |             
      Fat, Necrosis, Focal                 |                                                    2                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 2| 2| 9| 0| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 9| 9| 1| 8| 0| 0| 8| 0| 0| 0| 0| 3| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |             3                                                            |             
      Hydrometra                           |                      3     2                 2           2               |             
      Inflammation, Acute, Suppurative     |                   2           2                                          |             
      Endometrium, Hyperplasia, Cystic     |       3  3  1  1  3     1  3  3  3  4  3  3  3  1  3  1  3  3  3  4  3  3|             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                       3                  |             
      Infiltration Cellular, Lipocyte      |                                                                          |             
      Myeloid Cell, Hypercellularity       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Hyperplasia, Lymphoid |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Mediastinal, Abscess                 |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mesenteric, Angiectasis              |       2                                   1     3                        |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                      3  3|             
      Hematopoietic Cell Proliferation     |             3  4           3                          4  2  1           3|             
      Thrombosis                           |                                                       4                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |                                  3     3                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                       2                  |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                  2     3                                 |             
      Hemorrhage                           |             3                                                            |             
      Mineralization, Multifocal           |       2  2  2  2  2  1  2  2  1     1  2  2  1        2  1  2  1     2  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 0| 2| 2| 9| 0| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 5| 1| 3| 3| 3| 3| 3| 3|             
                                           | 4| 4| 9| 9| 1| 8| 0| 0| 8| 0| 0| 0| 0| 3| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2                                               2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                                           1                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Cornea, Fibrosis                     |                                           2                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                   +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |       1  1     1     1     1        1  1  1  1           1  1  1        1|             
      Cortex, Cyst                         |                   1                                                      |             
      Cortex, Fibrosis, Focal              |                            2        1                                    |             
      Cortex, Metaplasia, Focal, Osseous   |                                                                          |             
      Renal Tubule, Dilatation, Multifocal |                                                                          |             
      Renal Tubule, Necrosis, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 6| 9| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Cytologic Alterations                |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Necrosis, Focal                      |                                                                          |      4  1.0|
      Necrosis, Multifocal                 |                                                                          |      2  2.5|
      Kupffer Cell, Pigmentation           |                                                                          |      2  2.0|
      Sinusoid, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   8        |
      Inflammation, Acute, Suppurative     |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Fat, Necrosis, Focal                 |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Cyst, Multiple                       |                                                                          |      1  4.0|
      Inflammation, Acute, Suppurative     |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Subacute               |                                                                          |      2  3.0|
      Acinus, Atrophy, Multifocal          |                                                                          |      3  3.0|
      Acinus, Necrosis, Multifocal         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Erosion                              |                                                                          |      6  2.2|
      Hyperplasia                          |                                                                          |     11  1.7|
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 6| 9| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Erosion, Multiple                    |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Dysplasia                            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Artery, Inflammation, Subacute       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Cyst                                 |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
      Hypertrophy, Diffuse                 |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      2  1.5|
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      1  2.0|
      X-Zone, Degeneration, Fatty          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  49        |
      Pars Distalis, Angiectasis           |                                                                          |     10  2.3|
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |     16  1.8|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      Follicle, Cyst                       |                                                                          |      7  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |     11  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 6| 9| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Abscess, Multiple                    |                                                                          |      2  4.0|
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |     18  2.8|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Cystic                  |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrometra                           |                                                                          |      5  2.2|
      Inflammation, Acute, Suppurative     |                                                                          |      3  2.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     47  2.8|
      Endometrium, Hyperplasia             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Infiltration Cellular, Lipocyte      |                                                                          |      1  3.0|
      Myeloid Cell, Hypercellularity       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Deep Cervical, Hyperplasia, Lymphoid |                                                                          |      1  4.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Mediastinal, Abscess                 |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      3  3.0|
      Mesenteric, Angiectasis              |                                                                          |      5  1.8|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      4  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Fibrosis, Focal                      |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |     16  2.6|
      Thrombosis                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  50        |
      Cyst                                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 6| 9| 9| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
      Duct, Cyst                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Subacute                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Compression                          |                                                                          |      3  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Mineralization, Multifocal           |                                                                          |     39  1.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Hemorrhage                           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Nephropathy, Chronic                 |                                                                          |     33  1.0|
      Cortex, Cyst                         |                                                                          |      1  1.0|
      Cortex, Fibrosis, Focal              |                                                                          |      2  1.5|
      Cortex, Metaplasia, Focal, Osseous   |                                                                          |      1  2.0|
      Renal Tubule, Dilatation, Multifocal |                                                                          |      1  3.0|
      Renal Tubule, Necrosis, Multifocal   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 6| 7| 6| 6| 7| 5| 6| 5| 7| 5| 7| 5| 7| 2| 6| 5| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 5| 4| 8| 3| 2| 2| 3| 9| 2| 5| 3| 5| 3| 8| 3| 8| 2| 8| 3| 3| 3| 9| 2| 3| 3|             
                                           | 8| 0| 0| 0| 5| 7| 0| 9| 7| 7| 0| 7| 0| 8| 0| 6| 7| 8| 0| 0| 0| 9| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       3                                         X                        |             
      Cytologic Alterations                |    2                                                  1                  |             
      Eosinophilic Focus                   |          X                                                               |             
      Hematopoietic Cell Proliferation     |             2  2     2  1  2     1     2        2  2              2      |             
      Inflammation, Granulomatous          |    2        2  2                                   2  1           2      |             
      Mixed Cell Focus                     |          X                                X                              |             
      Necrosis, Focal                      |                            1     1                          1            |             
      Necrosis, Multifocal                 |                      1  1                                         2      |             
      Kupffer Cell, Pigmentation           |    2        3  1        1                       2  2  1  2  2     1     3|             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |    3        2  2     1  3  2     2     2        2  2              2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +                          +                          +      |             
      Inflammation, Acute, Suppurative     |    2        2                          2                                 |             
      Artery, Inflammation                 |                                                                   2      |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                            2                                             |             
      Inflammation, Acute, Suppurative     |             2                          2                                 |             
      Inflammation, Subacute               |                         2  2                                             |             
      Acinus, Atrophy, Multifocal          |    3                       2                                             |             
      Acinus, Hyperplasia, Focal           |                                           2                              |             
      Duct, Dilatation                     |    4                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |          2                                                               |             
      Hyperplasia                          |          2        2        2                                         2   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Multiple                    |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 6| 7| 6| 6| 7| 5| 6| 5| 7| 5| 7| 5| 7| 2| 6| 5| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 5| 4| 8| 3| 2| 2| 3| 9| 2| 5| 3| 5| 3| 8| 3| 8| 2| 8| 3| 3| 3| 9| 2| 3| 3|             
                                           | 8| 0| 0| 0| 5| 7| 0| 9| 7| 7| 0| 7| 0| 8| 0| 6| 7| 8| 0| 0| 0| 9| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Focal, Subacute        |                            1                                             |             
      Inflammation, Multifocal, Subacute   |                         2                                                |             
      Artery, Inflammation, Subacute       |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                           3                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                           2                              |             
      Pars Distalis, Hyperplasia           |    1  2           2     2                 2     2     2              2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation                 |                                                                   2      |             
      Follicle, Cyst                       |    1           2  2           2        1  2           X  3  1  2     2  2|             
      Follicle, Hyperplasia, Cystic        |                                                                          |             
      Follicular Cell, Hyperplasia         |    1  1  2  1  2  2           2        1  2        1  1     2  2     2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                4     4                          4              3         |             
      Abscess, Multiple                    |    4        4           4  4     4     4           4              4      |             
      Cyst                                 |          3        3                       4           3        1         |             
      Cyst, Multiple                       |       3                                                                 X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation, Acute, Suppurative     |                         2                                                |             
      Endometrium, Hyperplasia, Cystic     |    2  2  3  2  2  3  2  2  2  3  2  3  2  3  2  3  2  3  3  3  2  2  1  2|             
      Serosa, Inflammation, Acute,         |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                    +                     |             
      Leukocytosis                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hypercellularity       |    3        2  3     1  2  3     3     3        2  3              4      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |    4        4  4           3     3                 4              4      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 6| 7| 6| 6| 7| 5| 6| 5| 7| 5| 7| 5| 7| 2| 6| 5| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 5| 4| 8| 3| 2| 2| 3| 9| 2| 5| 3| 5| 3| 8| 3| 8| 2| 8| 3| 3| 3| 9| 2| 3| 3|             
                                           | 8| 0| 0| 0| 5| 7| 0| 9| 7| 7| 0| 7| 0| 8| 0| 6| 7| 8| 0| 0| 0| 9| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                         2|             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                                                         2|             
      Mediastinal, Abscess                 |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |    4        4           2  2     3     3           4              3      |             
      Mesenteric, Angiectasis              |                                     2                                1   |             
      Mesenteric, Hyperplasia, Lymphoid    |             4  2           3     2                                       |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                            3                                             |             
      Renal, Hyperplasia, Lymphoid         |    4        4  4        3  3     3              4                 4      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4  2     2  4     3  3  4     4     4  2     4  4              4      |             
      Pigmentation                         |                                     1                       2        1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Duct, Cyst                           |                                        3  2                             2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosis, Focal |                                                             4            |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization, Multifocal           |       1  1  2        2     1  1  2     1  2              1  2        1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                                                                         3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                                           1                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 6| 7| 6| 6| 7| 5| 6| 5| 7| 5| 7| 5| 7| 2| 6| 5| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 5| 4| 8| 3| 2| 2| 3| 9| 2| 5| 3| 5| 3| 8| 3| 8| 2| 8| 3| 3| 3| 9| 2| 3| 3|             
                                           | 8| 0| 0| 0| 5| 7| 0| 9| 7| 7| 0| 7| 0| 8| 0| 6| 7| 8| 0| 0| 0| 9| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                     2                                    |             
      Nephropathy, Chronic                 |    2  2  1  2  2  1  1  2  2  2  1  2  3  2     2  3  2  1  2  2  2  2  1|             
      Capsule, Inflammation, Subacute      |                                                                          |             
      Cortex, Cyst                         |                2                                                         |             
      Cortex, Metaplasia, Focal, Osseous   |                                                                          |             
      Glomerulus, Inflammation             |                                                                          |             
      Renal Tubule, Degeneration,          |                                                                          |             
          Multifocal                       |       2                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Serosa, Inflammation, Subacute       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 0| 3| 1| 3| 2| 8| 3| 2| 1| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 6| 0| 0| 7| 0| 3| 0| 7| 0| 5| 0| 0| 5| 8| 7| 0| 0| 5| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Cytologic Alterations                | X        2     2  3  2     2        2  2           2     3     2     2  1|             
      Eosinophilic Focus                   |                                                    X                     |             
      Hematopoietic Cell Proliferation     |    2        2                 2  3     2                                 |             
      Inflammation, Granulomatous          |    1        2                 2  3                       2               |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      |          1              2              1                                 |             
      Necrosis, Multifocal                 |                   1                                                      |             
      Kupffer Cell, Pigmentation           |    1     1  3     1        2  2  3  2  1  2  1     2  2  3  1  2     2  1|             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |    2        2     2           2        2  2  1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +  +                  |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Fat, Necrosis, Focal                 |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Inflammation, Subacute               |                                  3                                       |             
      Acinus, Atrophy, Multifocal          |                                  2                                       |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       2                                                        2     2   |             
      Hyperplasia                          |       2        2                                            1  2     2  2|             
      Ulcer                                |                                                                         2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Multiple                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 0| 3| 1| 3| 2| 8| 3| 2| 1| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 6| 0| 0| 7| 0| 3| 0| 7| 0| 5| 0| 0| 5| 8| 7| 0| 0| 5| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Focal, Subacute        |                                                                          |             
      Inflammation, Multifocal, Subacute   |                                           2                              |             
      Artery, Inflammation, Subacute       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                1     2                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          2                                                               |             
      Pars Distalis, Hyperplasia           |                2     2        2  2                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation                 |                                                                          |             
      Follicle, Cyst                       |    1  2              2           2        2     2  2           4        1|             
      Follicle, Hyperplasia, Cystic        |                                                                      3   |             
      Follicular Cell, Hyperplasia         | 1  1  2  1  1  1  1  3  2  1  1  3     1     1  2  2  2  2  2  3  1  3  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |    4              4           4        4     4                           |             
      Abscess, Multiple                    |             4                             4                              |             
      Cyst                                 |       2        3     2  3  3     2  4        X     4     2           4   |             
      Cyst, Multiple                       |                                                             4           4|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  2  4  3  3  3  3  3  2  3  2  2  2  3  2  2  3  3  2  3  3  3  4  2   |             
      Serosa, Inflammation, Acute,         |                                                                          |             
          Suppurative                      |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hypercellularity       |    4        3                 2        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |    3                                   4                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 0| 3| 1| 3| 2| 8| 3| 2| 1| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 6| 0| 0| 7| 0| 3| 0| 7| 0| 5| 0| 0| 5| 8| 7| 0| 0| 5| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                                                          |             
      Mediastinal, Abscess                 |                   2                                                      |             
      Mediastinal, Hyperplasia, Lymphoid   |             3     3           3                                          |             
      Mesenteric, Angiectasis              |                   1                 2                                   2|             
      Mesenteric, Hyperplasia, Lymphoid    |                                              2        3                  |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Polymorphonuclear               |    3              2                    2                                 |             
      Pancreatic, Hyperplasia, Lymphoid    |             3                                                            |             
      Renal, Hyperplasia, Lymphoid         |    3        3                 3        4                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4        4     3           4  4     4  4  3                           |             
      Pigmentation                         | 1     1  1     1                                         1        1  1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |    2                                                                     |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosis, Focal |                         1                                                |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         3                                                |             
      Mineralization, Multifocal           | 2  1  1  1  1  1     1     2  1     2        2     1     1  2  1  2  1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 0| 3| 1| 3| 2| 8| 3| 2| 1| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 6| 0| 0| 7| 0| 3| 0| 7| 0| 5| 0| 0| 5| 8| 7| 0| 0| 5| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 | 2     1  1  2  2  2  1     1  3  1  3  2  2     1  2  1  2  2  1  2  1  2|             
      Capsule, Inflammation, Subacute      |             2                                                            |             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Metaplasia, Focal, Osseous   |             1                    1                          2            |             
      Glomerulus, Inflammation             |    4                                         2                           |             
      Renal Tubule, Degeneration,          |                                                                          |             
          Multifocal                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                  2                                       |             
      Serosa, Inflammation, Subacute       |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 9| 8| 9| 9| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus                     |                                                                          |      2  3.0|
      Cytologic Alterations                |                                                                          |     15  2.0|
      Eosinophilic Focus                   |                                                                          |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |     15  1.9|
      Inflammation, Granulomatous          |                                                                          |     11  1.9|
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis, Focal                      |                                                                          |      6  1.2|
      Necrosis, Multifocal                 |                                                                          |      4  1.3|
      Kupffer Cell, Pigmentation           |                                                                          |     29  1.8|
      Sinusoid, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                                                          |     18  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Inflammation, Acute, Suppurative     |                                                                          |      3  2.0|
      Artery, Inflammation                 |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Inflammation, Acute, Suppurative     |                                                                          |      2  2.0|
      Inflammation, Subacute               |                                                                          |      3  2.3|
      Acinus, Atrophy, Multifocal          |                                                                          |      3  2.3|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  2.0|
      Duct, Dilatation                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Erosion                              |                                                                          |      4  2.0|
      Hyperplasia                          |                                                                          |     10  1.9|
      Ulcer                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 9| 8| 9| 9| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  49        |
      Erosion, Multiple                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Inflammation, Focal, Subacute        |                                                                          |      1  1.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      2  2.0|
      Artery, Inflammation, Subacute       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Hyperplasia, Focal                   |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |     12  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Artery, Inflammation                 |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                                                          |     21  1.9|
      Follicle, Hyperplasia, Cystic        |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         |                                                                          |     38  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Abscess                              |                                                                          |      9  3.9|
      Abscess, Multiple                    |                                                                          |     10  4.0|
      Cyst                                 |                                                                          |     16  2.9|
      Cyst, Multiple                       |                                                                          |      4  3.7|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Inflammation, Acute, Suppurative     |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     48  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 9| 8| 9| 9| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Serosa, Inflammation, Acute,         |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Leukocytosis                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Myeloid Cell, Hypercellularity       |                                                                          |     15  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      9  3.7|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  2.0|
      Mediastinal, Abscess                 |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |     11  3.1|
      Mesenteric, Angiectasis              |                                                                          |      5  1.6|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      6  2.7|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Polymorphonuclear               |                                                                          |      3  2.3|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      2  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |     12  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |     21  3.5|
      Pigmentation                         |                                                                          |     10  1.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Duct, Cyst                           |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |      2  2.5|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Subacute                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 9| 8| 9| 9| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Mineralization, Multifocal           |                                                                          |     30  1.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |                                                                          |     45  1.8|
      Capsule, Inflammation, Subacute      |                                                                          |      1  2.0|
      Cortex, Cyst                         |                                                                          |      1  2.0|
      Cortex, Metaplasia, Focal, Osseous   |                                                                          |      3  1.3|
      Glomerulus, Inflammation             |                                                                          |      2  3.0|
      Renal Tubule, Degeneration,          |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Serosa, Inflammation, Subacute       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 7| 9| 3| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 7| 9| 3| 3| 3| 3| 3| 3| 3| 2| 4| 0|             
                                           | 0| 7| 1| 6| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 5| 1| 1| 1| 1| 1| 1| 1| 4| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +     +  +                       +  +  A                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +                       +  A  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +                       +  A  A                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +                       +  A  A                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +                       +  A  A                       +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |    2                 1                 2                                 |             
      Inflammation, Granulomatous          |          1                          1                                    |             
      Necrosis, Focal                      |                                                    1                     |             
      Kupffer Cell, Pigmentation           |          1                                                               |             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               | 2  2        2        1                 2                                2|             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +                                                                     |             
      Inflammation, Acute, Suppurative     | 2  2                                                                     |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +                       +  +  +                       +  +  +|             
      Inflammation, Acute, Suppurative     |                                        4                                 |             
      Acinus, Atrophy, Multifocal          |                                     3                                    |             
      Duct, Dilatation                     |                                     4                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +                       +  +  +                       +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +                       +  +  +                       +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +                       +  +  +                       +  +  +|             
      Inflammation, Focal, Subacute        | 1                                                                        |             
      Inflammation, Multifocal, Subacute   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +                       +  +  +                       +  +  +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +                       +  +  +                       +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 7| 9| 3| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 7| 9| 3| 3| 3| 3| 3| 3| 3| 2| 4| 0|             
                                           | 0| 7| 1| 6| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 5| 1| 1| 1| 1| 1| 1| 1| 4| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +                       +  +  +                       +  +  +|             
      Hyperplasia                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +                       +  M  +                       +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                   3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |          1     1                 1                                   2   |             
      Follicle, Hyperplasia, Cystic        |                                              1                           |             
      Follicular Cell, Hyperplasia         |    1  1  1     2     1     1     2  2        3              2     2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |             4        1                                                  4|             
      Abscess, Multiple                    | 4  4                                                                     |             
      Cyst                                 |       2        2        3  2                                      2      |             
      Cyst, Multiple                       |                      3                                      3            |             
      Hemorrhage                           |                         2                                         3      |             
      Inflammation, Chronic                |       2                          3                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hydrometra                           |                                        2     2                       2   |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  2  2  2     3  3     3  3  3  3           3  3  3  3  3     3  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                        +                                 |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hypercellularity       | 3  3        3        2                 3                                3|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +     +              +  +  +        +              +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |          2           2                                                  2|             
      Inguinal, Hyperplasia, Lymphoid      |    2                                                                     |             
      Mediastinal, Abscess                 |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |    2                                                                     |             
      Mesenteric, Angiectasis              | 1                                                                 1      |             
      Mesenteric, Hyperplasia, Lymphoid    | 2                                                                        |             
      Pancreatic, Hyperplasia, Lymphoid    |    2                                                                     |             
      Renal, Hyperplasia, Lymphoid         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     | 4  4        3        3        2        4                                3|             
      Pigmentation                         |                                  1                                   1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 7| 9| 3| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 7| 9| 3| 3| 3| 3| 3| 3| 3| 2| 4| 0|             
                                           | 0| 7| 1| 6| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 5| 1| 1| 1| 1| 1| 1| 1| 4| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +                       +  +  +        +              +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +        +  +  +  +     +  +  +  +              +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +                       +  +  +                       +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +                       +  +  +                       +  +  +|             
      Mineralization, Multifocal           | 1  1     1                                1                       1  1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +        +           +  +  +                       +  +  +|             
      Hemorrhage                           |                                                                   2      |             
      Inflammation, Acute, Suppurative     |                                                                         2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +                       +  +  +                       +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +                       +  +  +                       +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  2  1  1  1  1  1  3  1  1  1  1  2        1     1  1  1  1  1  1  1  3|             
      Papilla, Necrosis                    |                      3                                                   |             
      Pelvis, Inflammation, Acute,         |                                                                          |             
          Suppurative                      |                      3                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +                       +  +  +                       +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 1| 6| 2| 3| 2| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4|             
                                           | 1| 6| 1| 1| 1| 1| 2| 6| 2| 2| 6| 8| 4| 2| 7| 2| 2| 7| 2| 5| 2| 3| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +              +  +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +              +  +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +              +  +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +              +  +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                                     X                                X   |             
      Hematopoietic Cell Proliferation     |                      2        2           3              1               |             
      Inflammation, Granulomatous          |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |    2                 2        2                                2         |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                        +               |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Fat, Necrosis, Focal                 | 3                                                        3               |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +                 +        +  +  +     +        A     +     +        +|             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Acinus, Atrophy, Multifocal          |    2                 2        2                          4               |             
      Duct, Dilatation                     |                                                          4               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +           +  +     +  +  +     +  +  +  A        +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +           +  +     +  +  +     +  +  +  A        +  +  +     +|             
      Erosion                              |          2                                   2              2     2      |             
      Hyperplasia                          |          2                                   2  2           2     2      |             
      Ulcer                                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +                 +        +  +  +     +        A           +        +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +                 +        +  +  +     +        +           +        +|             
      Inflammation, Focal, Subacute        |                                                                          |             
      Inflammation, Multifocal, Subacute   |    1                                2                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +                 +        +  +  +     +        A           +        +|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +                 +        +  +  +     +        A           +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 1| 6| 2| 3| 2| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4|             
                                           | 1| 6| 1| 1| 1| 1| 2| 6| 2| 2| 6| 8| 4| 2| 7| 2| 2| 7| 2| 5| 2| 3| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +                 +        +  +  +     +        A           +        +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +                 +        +  M  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +                 +        +  +  +     +        A           +        +|             
      Pars Distalis, Hyperplasia           |                               3  2                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Follicle, Cyst                       | 1           1  1                    1        2  1     1                  |             
      Follicle, Hyperplasia, Cystic        |                                                                          |             
      Follicular Cell, Hyperplasia         | 1  1     1  1  1     1     1        1  3     2  1     2  1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                               4           4                 2            |             
      Abscess, Multiple                    |    4                 4                             3           2         |             
      Cyst                                 |             3           X        3     4     2        4     2     4      |             
      Cyst, Multiple                       | 3              3                                                         |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  A  +        +  +  +  +|             
      Hydrometra                           |                                                                         2|             
      Inflammation, Acute, Suppurative     |    2                                                                     |             
      Endometrium, Hyperplasia, Cystic     | 3  2  3  4     4     2  3  4  2  3  1  4  2  3  4     4        3  3  4  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Myeloid Cell, Hypercellularity       |    3                 4        4           4                    3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +              +  +        +  +  +     +        A     +     +        +|             
      Iliac, Hyperplasia, Lymphoid         |                                           2                              |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Abscess                 |                                                                2         |             
      Mediastinal, Hyperplasia, Lymphoid   |                                           2              2               |             
      Mesenteric, Angiectasis              |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |    2                 2        2           2                    2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +                 +        +  +  +     +        A           +        +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                      3                                                   |             
      Hematopoietic Cell Proliferation     | 1  4           1     4        4  3  4  2  4              3     4         |             
      Pigmentation                         | 1                                                                 1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 9| 3| 3| 1| 6| 2| 3| 2| 3| 3| 9| 3| 3| 3| 1| 3| 3| 4|             
                                           | 1| 6| 1| 1| 1| 1| 2| 6| 2| 2| 6| 8| 4| 2| 7| 2| 2| 7| 2| 5| 2| 3| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +                 +        +  +  +     +        A           +        +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +                 +        +  +  +     +        +           +        +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +        +  +  +  +        +  +  +     +        +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +                 +        +  +  +     +        +           +        +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +                 +        +  +  +     +        A           +        +|             
      Mineralization, Multifocal           |                      1        1  1        1                             1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +                 +        +  +  +     +        +           +        +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    |    +                 +        +  +  +     +        +           +        +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +                 +        +  +  +     +        A           +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2  1  1  1  1  1  1  1  1  2  2  2  1  1  1  1     1  1  1  1  1  1  1|             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Inflammation, Acute,         |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +                 +        +  +  +     +        A           +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 8| 9| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  49        |
      Eosinophilic Focus                   |                                                                          |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |      7  1.9|
      Inflammation, Granulomatous          |                                                                          |      2  1.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Kupffer Cell, Pigmentation           |                                                                          |      1  1.0|
      Sinusoid, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                                                          |     10  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation, Acute, Suppurative     |                                                                          |      2  2.0|
      Fat, Necrosis, Focal                 |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  19        |
      Inflammation, Acute, Suppurative     |                                                                          |      1  4.0|
      Acinus, Atrophy, Multifocal          |                                                                          |      5  2.6|
      Duct, Dilatation                     |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  24        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  24        |
      Erosion                              |                                                                          |      4  2.0|
      Hyperplasia                          |                                                                          |      5  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  18        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  19        |
      Inflammation, Focal, Subacute        |                                                                          |      1  1.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 8| 9| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  18        |
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  18        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  17        |
      Pars Distalis, Hyperplasia           |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
      Follicle, Cyst                       |                                                                          |     11  1.2|
      Follicle, Hyperplasia, Cystic        |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |     24  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Abscess                              |                                                                          |      6  3.2|
      Abscess, Multiple                    |                                                                          |      6  3.5|
      Cyst                                 |                                                                          |     13  2.8|
      Cyst, Multiple                       |                                                                          |      4  3.0|
      Hemorrhage                           |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  43        |
      Hydrometra                           |                                                                          |      4  2.0|
      Inflammation, Acute, Suppurative     |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     39  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
      Myeloid Cell, Hypercellularity       |                                                                          |     11  3.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  23        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      4  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Mediastinal, Abscess                 |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 8| 9| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      3  2.0|
      Mesenteric, Angiectasis              |                                                                          |      2  1.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |     18  3.2|
      Pigmentation                         |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  19        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  33        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  19        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  18        |
      Mineralization, Multifocal           |                                                                          |     12  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  21        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Acute, Suppurative     |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  18        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  49        |
      Nephropathy, Chronic                 |                                                                          |     46  1.3|
      Papilla, Necrosis                    |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 8| 9| 9| 8| 8| 8| 9| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pelvis, Inflammation, Acute,         |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  18        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 5| 6| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 5| 9| 3| 3| 3| 6|             
                                           | 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 2| 8| 3| 6| 2| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +                             +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +  +                             +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +                             +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +                             +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +                             +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +                             +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +                    +        +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +                    +        +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +                    +        +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +                    +        +     A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      3                                                   |             
      Basophilic Focus                     |                                                                          |             
      Cytologic Alterations                |                                        2                                 |             
      Eosinophilic Focus                   |                                           X                    X         |             
      Hematopoietic Cell Proliferation     |                               3                             2            |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      | 1                                                  1                     |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                                             2           2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                   +        +            |             
      Inflammation, Acute, Suppurative     |                                                             2            |             
      Fat, Necrosis, Focal                 |                4                                   3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +                             +     A        +  +  +           +|             
      Acinus, Atrophy, Multifocal          |                                                             1            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +                             +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +                             +  +  A        +  +  +           +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +                             +  +  A        +  +  +           +|             
      Erosion                              |                                           2                              |             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +                             +     A        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +                             +     +        +  +  +           +|             
      Inflammation, Focal, Subacute        |                                                                          |             
      Inflammation, Multifocal, Subacute   |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +                             +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +                             +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +                             +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +                             +     A        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 5| 6| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 5| 9| 3| 3| 3| 6|             
                                           | 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 2| 8| 3| 6| 2| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +                             +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +           +        +        +     A        +  +  +           +|             
      Pars Distalis, Hyperplasia           |                                                          2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       | 1  2  2     1        1                          2  1                     |             
      Follicular Cell, Hyperplasia         | 3  1                 2  1        1                 1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +                           |             
      Hemorrhage                           |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                             4           4|             
      Cyst                                 |                   2                             3        3  3        2   |             
      Cyst, Multiple                       |          2                                                               |             
      Hyperplasia, Cystic                  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +     +     +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3     3     4  3  3  3     3     3  3  1  4     3  3     3     3  4  3  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hypercellularity       |                                                             2           2|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +                    +     +  +     +        +  +  +           +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                             3           2|             
      Mesenteric, Angiectasis              |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                     2                       3            |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +                             +     +        +  +  +           +|             
      Hyperplasia, Lymphoid                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                         3                                                |             
      Hematopoietic Cell Proliferation     |          3     1              4     2  2              2  2  4           2|             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +                             +     +        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +                    +        +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +     +        +     +  +     +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 5| 6| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 5| 9| 3| 3| 3| 6|             
                                           | 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 2| 8| 3| 6| 2| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +                             +     +        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +                    +        +     +        +  +  +           +|             
      Compression                          |                               X                                          |             
      Mineralization, Multifocal           |       1  1                             1                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +                             +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +                             +     +        +  +  +           +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +                             +     +        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  2  1  2  1  2  1  1  1  1  2  1  1  2  2     1     1  3  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +                             +     A        +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 5| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 9| 2| 3| 5| 9| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                    X                     |             
      Cytologic Alterations                |                                                                          |             
      Eosinophilic Focus                   |                                                                   X      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Granulomatous          |                                        2              1                  |             
      Mixed Cell Focus                     |             X                                                            |             
      Necrosis, Focal                      |    2                                                                     |             
      Kupffer Cell, Pigmentation           |                                                       1                  |             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Fat, Necrosis, Focal                 |                         4                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +     +  +                                +                     |             
      Acinus, Atrophy, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +     +  +              +     +           +  +                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +     +  +              +     +           +  +                  |             
      Erosion                              |          2                       2     2              2                  |             
      Hyperplasia                          |          2                       2     2              2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +     +  +                                +                     |             
      Inflammation, Focal, Subacute        |                   1                                                      |             
      Inflammation, Multifocal, Subacute   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +     +  +              +                 +                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +     +  +              +                 +                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +     +  +              +                 +                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 5| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 9| 2| 3| 5| 9| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +     +  +                                +                     |             
      Pars Distalis, Hyperplasia           |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                      2                    1  1              1  1         |             
      Follicular Cell, Hyperplasia         |                                  2        1  1     1           1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |                      2  4           2  1           2  2           4  3  3|             
      Cyst, Multiple                       |                               2                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +        +  +     +        +  +  +        +  +  +  +   |             
      Hydrometra                           |                            2                                2        2   |             
      Endometrium, Hyperplasia, Cystic     | 3     3     3  3  3        3  3     3        4  4  3        3  3  3  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hypercellularity       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +  +                    +           +        +           +|             
      Iliac, Hyperplasia, Lymphoid         |                                                             2            |             
      Inguinal, Hyperplasia, Lymphoid      |                   2                                                      |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mesenteric, Angiectasis              |             3                                                            |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                   2                                                      |             
      Renal, Hyperplasia, Lymphoid         |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +     +  +                                +                    +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |    4     3                                                  2  2        2|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +     +  +  +  +              +           +     +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 5| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 9| 2| 3| 5| 9| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +     +  +                                +                     |             
      Compression                          |                                                                          |             
      Mineralization, Multifocal           |    1           1                                   1                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +     +  +                                +                     |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  1     3  1  2  1  1  1  1  1     1  1  2  1  1  1  1  1  1  1     1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +     +  +                                +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 8| 9| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                          |      1     |
      Cytologic Alterations                |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      3     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Inflammation, Granulomatous          |                                                                          |      2  1.5|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Focal                      |                                                                          |      3  1.3|
      Kupffer Cell, Pigmentation           |                                                                          |      1  1.0|
      Sinusoid, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation, Acute, Suppurative     |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                                                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  12        |
      Acinus, Atrophy, Multifocal          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  16        |
      Erosion                              |                                                                          |      5  2.0|
      Hyperplasia                          |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  13        |
      Inflammation, Focal, Subacute        |                                                                          |      1  1.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 8| 9| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  14        |
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Follicle, Cyst                       |                                                                          |     12  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |     11  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  49        |
      Abscess                              |                                                                          |      2  4.0|
      Cyst                                 |                                                                          |     14  2.6|
      Cyst, Multiple                       |                                                                          |      2  2.0|
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  38        |
      Hydrometra                           |                                                                          |      3  2.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     33  3.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Myeloid Cell, Hypercellularity       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  20        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.5|
      Mesenteric, Angiectasis              |                                                                          |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      2  2.5|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  15        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 9| 8| 8| 9| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |     14  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  13        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  29        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  13        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  14        |
      Compression                          |                                                                          |      1     |
      Mineralization, Multifocal           |                                                                          |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  13        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  49        |
      Nephropathy, Chronic                 |                                                                          |     45  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 1| 2| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 9| 8| 5| 2| 2| 2| 2| 2| 8| 3| 2| 5| 2| 5| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 9| 9| 9| 1| 0| 9| 9| 9| 9| 9| 0| 0| 9| 3| 9| 1| 0| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  M  +|             
      Epithelium, Hyperplasia              |                                                                1         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1                                                                        |             
      Basophilic Focus                     |                                        X     X                           |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Inflammation, Multifocal, Subacute   |             1                                                            |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      |                2                                      4  1               |             
      Necrosis, Multifocal                 |                                                                          |             
      Centrilobular, Necrosis              |                                     1                                    |             
      Sinusoid, Amyloid Deposition         |                                                                          |             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                     2                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Acinus, Atrophy, Focal               |                                                          1               |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Acinus, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +                 +     +  +        +     +                    +  +   |             
      Dysplasia                            | 1  1                 2     1  2        2     2                    3  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 1| 2| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 9| 8| 5| 2| 2| 2| 2| 2| 8| 3| 2| 5| 2| 5| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 9| 9| 9| 1| 0| 9| 9| 9| 9| 9| 0| 0| 9| 3| 9| 1| 0| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hyperplasia, Focal                   |    2                                                                     |             
      Hypertrophy, Focal                   |                   2                                      2               |             
      Hypertrophy, Multifocal              |                                                                2         |             
      Mineralization, Focal                |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Focal, Hematoidin      |                                                                          |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                        2                                 |             
      Spindle Cell, Hyperplasia            |                               3                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                      2  1                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |    2                                                                     |             
      Follicle, Degeneration, Cystic       |                      2                                                   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
      Hemorrhage                           |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                3         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +                          +           +                          +|             
      Inflammation, Subacute               | 2  3  4                                                                  |             
      Duct, Cyst                           |                                  3                                       |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 2                        |             
      Inflammation, Subacute               |                         1        2                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Subacute               |    3                                                                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 1| 2| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 9| 8| 5| 2| 2| 2| 2| 2| 8| 3| 2| 5| 2| 5| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 9| 9| 9| 1| 0| 9| 9| 9| 9| 9| 0| 0| 9| 3| 9| 1| 0| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                +                                                         |             
      Leukocytosis                         |                4                                                         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hypercellularity       |          3     4                                   2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Ectasia                    |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |       4        4                                                        4|             
      Mesenteric, Angiectasis              |                   2     2  2  1                          1               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |          2     4                    3     3           4                  |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              |                3                                                         |             
      Cyst                                 |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Subacute        |                2                                      3              2  3|             
      Inflammation, Multifocal, Subacute   |          3  2                                                            |             
      Ulcer                                |                                                 2           3            |             
      Epidermis, Hyperplasia, Focal        |                                                                          |             
      Epidermis, Hyperplasia, Multifocal   |    2                                                              2      |             
      Subcutaneous Tissue, Edema, Focal    |                3                                                         |             
      Subcutaneous Tissue, Fibrosis, Focal |                3                                            3            |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |                                                                   2      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |                                                             2            |             
      Subcutaneous Tissue, Mineralization, |                                                                          |             
           Focal                           |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                2                                                         |             
      Mineralization, Multifocal           | 2  2  2  2        2  2  2  1     2     1  2  2     1  1  2     1         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 1| 2| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 9| 8| 5| 2| 2| 2| 2| 2| 8| 3| 2| 5| 2| 5| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 9| 9| 9| 1| 0| 9| 9| 9| 9| 9| 0| 0| 9| 3| 9| 1| 0| 9| 9| 4| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Cataract                             |                                                                          |             
      Conjunctiva, Inflammation, Subacute  |                                                                      3   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Hydronephrosis                       |                                  4                                       |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy, Chronic                 | 1  1  1  1  1           1  1  1        1  2  2        1  1     1  1  1  1|             
      Glomerulus, Amyloid Deposition       |                                                                          |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                                                    3                     |             
      Right, Atrophy                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                    +                     |             
      Inflammation, Suppurative            |                                                    4                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                  2                                       |             
      Inflammation, Suppurative            |                                                                          |             
      Wall, Mineralization, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 2| 8| 2| 8| 2| 3| 9| 2| 1| 2| 2| 3| 2| 8| 3| 3| 0| 3| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 9| 9| 3| 9| 0| 1| 9| 6| 9| 4| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                      X   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Multifocal, Subacute   |                                                    2                     |             
      Mixed Cell Focus                     |                                                                X        X|             
      Necrosis, Focal                      |       3                                                                  |             
      Necrosis, Multifocal                 |                                                    3                     |             
      Centrilobular, Necrosis              |                                                                          |             
      Sinusoid, Amyloid Deposition         |       4                                                                  |             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +           +                  |             
      Fat, Necrosis, Focal                 |                                           3           3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Suppurative     |       3                                                                  |             
      Acinus, Atrophy, Focal               |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                  1                                       |             
      Acinus, Necrosis                     |       4                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |       +     +                    +     +  +  +                 +         |             
      Dysplasia                            |       3     2                          1  1  4                 1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 2| 8| 2| 8| 2| 3| 9| 2| 1| 2| 2| 3| 2| 8| 3| 3| 0| 3| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 9| 9| 3| 9| 0| 1| 9| 6| 9| 4| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      3   |             
      Cyst                                 |                                        1                                 |             
      Fibrosis, Focal                      |                                                                      3   |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   | 3  2                                                                 2   |             
      Hypertrophy, Multifocal              |                                                                          |             
      Mineralization, Focal                |                                                                      3   |             
      Necrosis                             |       2                                                                  |             
      Pigmentation, Focal, Hematoidin      |                                                                      2   |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |          2                                                               |             
      Spindle Cell, Hyperplasia            |    2     2                                                        3      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |       4                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |             2                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                1     1   |             
      Follicle, Degeneration, Cystic       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                  1                                2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |          2                                                  3            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +           +                    +                 +  +     +  +  +  +  +|             
      Inflammation, Subacute               | 3           4                    3                    3     4  4         |             
      Duct, Cyst                           |                                                                3     3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Subacute               |             2  4              4                          1               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            3                                             |             
      Inflammation, Subacute               |                            3                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 2| 8| 2| 8| 2| 3| 9| 2| 1| 2| 2| 3| 2| 8| 3| 3| 0| 3| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 9| 9| 3| 9| 0| 1| 9| 6| 9| 4| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hypercellularity       |                4     3  2     4           2                 2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Ectasia                    |                                                          2               |             
      Inguinal, Hyperplasia, Lymphoid      |                                                          3  4  2         |             
      Mesenteric, Angiectasis              | 2  1              1                    2  1           3  2  1     2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       3                                                                  |             
      Hematopoietic Cell Proliferation     |             2        3                    4     3  4  3     3            |             
      Necrosis                             |       3                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                  1     1                             1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Subacute        |          2           2                                                   |             
      Inflammation, Multifocal, Subacute   |                                                    1                     |             
      Ulcer                                |                                     3                                    |             
      Epidermis, Hyperplasia, Focal        | 2     1  2                       2                 1                     |             
      Epidermis, Hyperplasia, Multifocal   |                                           1                              |             
      Subcutaneous Tissue, Edema, Focal    |                                                                          |             
      Subcutaneous Tissue, Fibrosis, Focal | 2  2  3                             3                                    |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |                                           1        2                     |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |                                                                          |             
      Subcutaneous Tissue, Mineralization, |                                                                          |             
           Focal                           |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization, Multifocal           |    2  2  2           2           2     2  2  2  1  2     2  2  2     2  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 2| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 9| 2| 2| 8| 2| 8| 2| 3| 9| 2| 1| 2| 2| 3| 2| 8| 3| 3| 0| 3| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 9| 9| 3| 9| 0| 1| 9| 6| 9| 4| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                               3                                          |             
      Hemorrhage, Multifocal               |                                  2                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                           2                              |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                               2                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                         2|             
      Conjunctiva, Inflammation, Subacute  |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                4                                                         |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |                4              1                                          |             
      Nephropathy, Chronic                 | 1  1  3  1  1           3        1     1  1  1  1  1  2  1  1     1     1|             
      Glomerulus, Amyloid Deposition       |       2                                                                  |             
      Papilla, Necrosis                    |       2                                                                  |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Right, Atrophy                       |                3                                                         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                2                                                         |             
      Inflammation, Suppurative            |                               2                                          |             
      Wall, Mineralization, Focal          |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  47        |
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                          |      3     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      2  1.5|
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis, Focal                      |                                                                          |      4  2.5|
      Necrosis, Multifocal                 |                                                                          |      1  3.0|
      Centrilobular, Necrosis              |                                                                          |      1  1.0|
      Sinusoid, Amyloid Deposition         |                                                                          |      1  4.0|
      Sinusoid, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Necrosis, Focal                 |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Inflammation, Acute, Suppurative     |                                                                          |      1  3.0|
      Acinus, Atrophy, Focal               |                                                                          |      1  1.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  1.0|
      Acinus, Necrosis                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  16        |
      Dysplasia                            |                                                                          |     15  1.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
      Capsule, Hyperplasia                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1  1.0|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      5  2.2|
      Hypertrophy, Multifocal              |                                                                          |      1  2.0|
      Mineralization, Focal                |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation, Focal, Hematoidin      |                                                                          |      1  2.0|
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      2  2.0|
      Spindle Cell, Hyperplasia            |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  46        |
      Pars Distalis, Cyst                  |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Follicle, Cyst                       |                                                                          |      3  1.3|
      Follicle, Degeneration, Cystic       |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  16        |
      Inflammation, Subacute               |                                                                          |      9  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Duct, Cyst                           |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      6  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Leukocytosis                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Myeloid Cell, Hypercellularity       |                                                                          |      9  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
      Inguinal, Ectasia                    |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      6  3.5|
      Mesenteric, Angiectasis              |                                                                          |     14  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  48        |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |     12  3.2|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  46        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  49        |
      Inflammation, Focal, Subacute        |                                                                          |      6  2.3|
      Inflammation, Multifocal, Subacute   |                                                                          |      3  2.0|
      Ulcer                                |                                                                          |      3  2.7|
      Epidermis, Hyperplasia, Focal        |                                                                          |      5  1.6|
      Epidermis, Hyperplasia, Multifocal   |                                                                          |      3  1.7|
      Subcutaneous Tissue, Edema, Focal    |                                                                          |      1  3.0|
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |      6  2.7|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Multifocal                       |                                                                          |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Subacute                 |                                                                          |      1  2.0|
      Subcutaneous Tissue, Mineralization, |                                                                          |            |
           Focal                           |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization, Multifocal           |                                                                          |     31  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  2.0|
      Conjunctiva, Inflammation, Subacute  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Bacterium                            |                                                                          |      1  4.0|
      Hydronephrosis                       |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Nephropathy, Chronic                 |                                                                          |     34  1.2|
      Glomerulus, Amyloid Deposition       |                                                                          |      1  2.0|
      Papilla, Necrosis                    |                                                                          |      1  2.0|
      Renal Tubule, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Right, Atrophy                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  49        |
      Inflammation, Subacute               |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Wall, Mineralization, Focal          |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 5| 7| 3| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 5|             
                             DAY ON TEST   | 8| 7| 3| 5| 3| 0| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 5|             
                                           | 9| 8| 0| 7| 0| 1| 6| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mineralization, Focal                |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X              X        X  X        X               |             
      Clear Cell Focus                     |                                  X                                       |             
      Cytologic Alterations                |    2  3  1  3        3  3  3  3  3  1  3  3  2  3  3  3  3        3  3  2|             
      Eosinophilic Focus                   |             2                       X                                    |             
      Inflammation, Granulomatous          |       3  1  3        2  3  2  2  3  1  3  3     2  3  3  3        2  3  2|             
      Mixed Cell Focus                     |             X                          X                                 |             
      Necrosis, Multifocal                 |                                                                      2   |             
      Kupffer Cell, Pigmentation           |    2  3  1  3        3  3  3  3  4  1  4  3  2  3  3  3  4        3  3  2|             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Fat, Mineralization, Focal           |                                     2                                    |             
      Fat, Necrosis, Focal                 |                                     3                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                                                                          |             
      Acinus, Inflammation, Focal, Subacute|                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +     +           +     +     +  +  +  +  +  +     +        +      |             
      Dysplasia                            |       4     2           2     2     3  2  1  2  1  1     2        2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 5| 7| 3| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 5|             
                             DAY ON TEST   | 8| 7| 3| 5| 3| 0| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 5|             
                                           | 9| 8| 0| 7| 0| 1| 6| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |             1        1     1     3     2        1                        |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                2                                                         |             
      Spindle Cell, Hyperplasia            |                                                 2                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                  1                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |    1  1  1  2           2  2  2  1  2  2  1  1  1  1  2  1        1  2  1|             
      Follicular Cell, Hyperplasia         |    1  3  2  2        1  3  3  2  2  3  3  2  1  3  2  3  1        3  3  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                 3                        |             
      Inflammation, Subacute               |             1        2                       1                           |             
                                            __________________________________________________________________________|             
   Penis                                   |          M                                                               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                   +                       +  +                           |             
      Inflammation, Subacute               |                                           4  3                           |             
      Duct, Cyst                           |                   3                                                      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |             2  2  2                                            4        1|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                4         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Degeneration    |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Myeloid Cell, Hypercellularity       |                2  1                                            2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                         3|             
      Inguinal, Hyperplasia, Lymphoid      |             4  3  2                                         2        2   |             
      Mesenteric, Angiectasis              |       1              2  3              1     1        1           1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 5| 7| 3| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 5|             
                             DAY ON TEST   | 8| 7| 3| 5| 3| 0| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 5|             
                                           | 9| 8| 0| 7| 0| 1| 6| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |             3              2                          3           3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   2                                                  4   |             
      Pigmentation                         |    1  2  1  1  2     1  1     1  1  2  1  1  1  1     1     2  2  1      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |                                                                4         |             
      Necrosis                             |                   2                                         3            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Subacute        |                            2                                             |             
      Epidermis, Hyperplasia, Focal        |                            2              2                              |             
      Subcutaneous Tissue, Fibrosis, Focal |                3  4        3              2                              |             
      Subcutaneous Tissue, Hemorrhage      |                   4                                                      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |                   3                                         3            |             
      Subcutaneous Tissue, Mineralization, |                                                                          |             
           Focal                           |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           | 1  2  2           1  2     2  2  2  2  2  1  2  2     2     1        1  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                2         |             
      Nephropathy, Chronic                 |    1  1  3  1  1  1  1  1  3  3  3  2  2  1  1  2  2  1  3     2  1  1  3|             
      Artery, Inflammation                 |                                                                          |             
      Cortex, Cyst                         |                            2     2     1                             1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 5| 7| 3| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 5|             
                             DAY ON TEST   | 8| 7| 3| 5| 3| 0| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 5|             
                                           | 9| 8| 0| 7| 0| 1| 6| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Left, Fibrosis, Focal                |                                                                          |             
      Renal Tubule, Dilatation, Multifocal |                                                                          |             
      Renal Tubule, Hyperplasia, Cystic    |                                                          1               |             
      Renal Tubule, Hyperplasia            |                      2        4                       1  1               |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                1                                            2  2         |             
      Renal Tubule, Epithelium, Cytomegaly |    3  2  3  3  1  2  3  3  4  4  4  2  3  3  3  3  3  3  3  1  1  3  3  3|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Bulbourethral Gland, Cyst            |                                                                          |             
      Bulbourethral Gland, Inflammation,   |                                                                          |             
           Subacute                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
      Inflammation, Subacute               |                                                                2         |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 5|             
                                           | 1| 1| 0| 1| 1| 1| 5| 1| 1| 4| 1| 7| 1| 1| 1| 1| 5| 5| 1| 1| 1| 4| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X              X     X                              |             
      Clear Cell Focus                     |                                                                          |             
      Cytologic Alterations                | 3  3     3  3  3     3  3  1  2  1  3  3  3  3  2  3  3  2  2  1  3  2  3|             
      Eosinophilic Focus                   |                                        X                                 |             
      Inflammation, Granulomatous          | 2  3     3  2  2     2  2     2  2  2  2  3  3     3  3  2  2     3  2  2|             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Kupffer Cell, Pigmentation           | 3  3     3  2  3     3  3  1  3  2  3  3  3  4     3  3  2  2     3  2  1|             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                  2                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Mineralization, Focal           |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |             2                                                            |             
      Acinus, Inflammation, Focal, Subacute|             2                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                             2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                2         |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +        +  +              +     +  +     +     +     +  +        +   |             
      Dysplasia                            | 3  3        2  2              2     2  3     3     2     2  2        3   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 5|             
                                           | 1| 1| 0| 1| 1| 1| 5| 1| 1| 4| 1| 7| 1| 1| 1| 1| 5| 5| 1| 1| 1| 4| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |    2        2                                                            |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                          |             
      Spindle Cell, Hyperplasia            |                                              1                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      2                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       | 2  1     2  2  1     2  1     2  2     2  2  2     2  1  2  1     2  2  1|             
      Follicular Cell, Hyperplasia         | 3  2     2  2  2  1  3  3  2  1  2  2  3  2  3     2  2  3  3        2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                         3|             
      Inflammation, Subacute               |                      1                                                   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                             +            |             
      Inflammation, Subacute               |                                                                          |             
      Duct, Cyst                           |                                                             3            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                      1        4                 4                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                               4                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                         2                                                |             
      Seminiferous Tubule, Degeneration    |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +                             +         |             
      Leukocytosis                         |                                  2                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hypercellularity       |                               1  2                             2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |       2                                         3        1               |             
      Mesenteric, Angiectasis              |                      2  1           2  2  2                          1  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 5|             
                                           | 1| 1| 0| 1| 1| 1| 5| 1| 1| 4| 1| 7| 1| 1| 1| 1| 5| 5| 1| 1| 1| 4| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                  2              2              2         |             
      Pigmentation                         | 2  1  2     1  1     2  2  2  1  1  2  2  2  1     1  1  1  1     1  1  1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 3                        |             
      Necrosis                             |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Subacute        |                                                                          |             
      Epidermis, Hyperplasia, Focal        |                         2                          1                     |             
      Subcutaneous Tissue, Fibrosis, Focal |                         2  2                       1                     |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |                                                    1                     |             
      Subcutaneous Tissue, Mineralization, |                                                                          |             
           Focal                           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           | 1  1     2  2  1     1  2  1  1  2  2  1  2           2  2  2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Suppurative     |                                     2                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy, Chronic                 | 1  2     1  3  2  1  3  1  1  1  2  1  3  3  1     1  1  3  2     2  2  3|             
      Artery, Inflammation                 |                            3                                             |             
      Cortex, Cyst                         |    1     2     2     2                                                  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 3| 3| 3| 2| 6| 3| 3| 3| 9| 3| 3| 5|             
                                           | 1| 1| 0| 1| 1| 1| 5| 1| 1| 4| 1| 7| 1| 1| 1| 1| 5| 5| 1| 1| 1| 4| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Left, Fibrosis, Focal                |                               4                                          |             
      Renal Tubule, Dilatation, Multifocal |                                                 2                        |             
      Renal Tubule, Hyperplasia, Cystic    |                      1                 1  1                              |             
      Renal Tubule, Hyperplasia            |                                     1              1     1               |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |       2                                                                  |             
      Renal Tubule, Epithelium, Cytomegaly | 3  3     3  3  3  2  3  3  2  3  3  3  3  3  3     3  3  3  3     3  3  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                           +     +                        |             
      Dilatation                           |                                                 3                        |             
      Inflammation, Suppurative            |                                                 3                        |             
      Bulbourethral Gland, Cyst            |                                           3                              |             
      Bulbourethral Gland, Inflammation,   |                                                                          |             
           Subacute                        |                                           2                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Mineralization                       |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 4| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 5| 5| 3| 5| 5| 5| 5|                                            |            |
                                           | 4| 7| 7| 6| 6| 1| 7| 6| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  48        |
      Mineralization, Focal                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  49        |
      Basophilic Focus                     |                                                                          |      8     |
      Clear Cell Focus                     |                                                                          |      1     |
      Cytologic Alterations                |                                                                          |     43  2.6|
      Eosinophilic Focus                   |                                                                          |      3  2.0|
      Inflammation, Granulomatous          |                                                                          |     38  2.4|
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Kupffer Cell, Pigmentation           |                                                                          |     41  2.7|
      Sinusoid, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Mineralization, Focal           |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Acinus, Atrophy, Focal               |                                                                          |      1  2.0|
      Acinus, Inflammation, Focal, Subacute|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  24        |
      Dysplasia                            |                                                                          |     24  2.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 4| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 5| 5| 3| 5| 5| 5| 5|                                            |            |
                                           | 4| 7| 7| 6| 6| 1| 7| 6| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis, Focal                      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
      Capsule, Hyperplasia                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Hypertrophy, Focal                   |                                                                          |      8  1.6|
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  49        |
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Follicle, Cyst                       |                                                                          |     38  1.6|
      Follicular Cell, Hyperplasia         |                                                                          |     41  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
      Granuloma Sperm                      |                                                                          |      2  3.0|
      Inflammation, Subacute               |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   4        |
      Inflammation, Subacute               |                                                                          |      2  3.5|
      Duct, Cyst                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |      8  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
      Seminiferous Tubule, Degeneration    |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 4| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 5| 5| 3| 5| 5| 5| 5|                                            |            |
                                           | 4| 7| 7| 6| 6| 1| 7| 6| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   3        |
      Leukocytosis                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
      Myeloid Cell, Hypercellularity       |                                                                          |      6  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Axillary, Hyperplasia, Lymphoid      |                                                                          |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      8  2.4|
      Mesenteric, Angiectasis              |                                                                          |     14  1.6|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      5  2.4|
      Pigmentation                         |                                                                          |     39  1.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  45        |
      Atrophy                              |                                                                          |      2  3.5|
      Necrosis                             |                                                                          |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Inflammation, Focal, Subacute        |                                                                          |      1  2.0|
      Epidermis, Hyperplasia, Focal        |                                                                          |      4  1.8|
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |      7  2.4|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Subacute                 |                                                                          |      3  2.3|
      Subcutaneous Tissue, Mineralization, |                                                                          |            |
           Focal                           |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Mineralization, Multifocal           |                                                                          |     36  1.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 4| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 5| 5| 5| 5| 3| 5| 5| 5| 5|                                            |            |
                                           | 4| 7| 7| 6| 6| 1| 7| 6| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Inflammation, Acute, Suppurative     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |                                                                          |     45  1.8|
      Artery, Inflammation                 |                                                                          |      1  3.0|
      Cortex, Cyst                         |                                                                          |      9  1.7|
      Left, Fibrosis, Focal                |                                                                          |      1  4.0|
      Renal Tubule, Dilatation, Multifocal |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia, Cystic    |                                                                          |      4  1.0|
      Renal Tubule, Hyperplasia            |                                                                          |      7  1.6|
      Renal Tubule, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                          |      4  1.8|
      Renal Tubule, Epithelium, Cytomegaly |                                                                          |     46  2.8|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Bulbourethral Gland, Cyst            |                                                                          |      1  3.0|
      Bulbourethral Gland, Inflammation,   |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 3| 5| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 6| 5| 7| 2| 6| 3| 3| 3| 3| 3| 3| 3| 7| 2| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 1| 2| 8| 2| 1| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 1| 3| 1| 2| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +        +  +  +  +  A                       A  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  A  +  +  +                       A  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  A  +  +  A                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +  +  +  A                       A  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +  +  +  +                 +     A  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +  +  +  A                 +     A  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  A  +  +  +                       A  +     +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  A  +  +  A                       A  +     +                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                            X                    X                        |             
      Cytologic Alterations                |    2  2  1  1  1  1  1  2  3  2  1     1  2     1  1  2  1  2  2  2  2  1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Granulomatous          |    1              1  2     2     1        1           1     1            |             
      Inflammation, Multifocal, Subacute   |          2                                                               |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      |          2                                                               |             
      Kupffer Cell, Pigmentation           |    2     1              2  2     1     1  2     1  1  2  1  2  2  1  2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +                       +  +     +                  |             
      Erosion                              |                   2                                                      |             
      Hyperplasia                          |       2           2                                                      |             
      Ulcer                                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +  +  +  +                       +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +  +  +  +  +                       +  +     +                  |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +  +  +  +                       +  +     +                  |             
      Hyperplasia                          |          1                                      1                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  M  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +  +  +                       +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 3| 5| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 6| 5| 7| 2| 6| 3| 3| 3| 3| 3| 3| 3| 7| 2| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 1| 2| 8| 2| 1| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 1| 3| 1| 2| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |    2        3              2  1  2        1     1  1     1  1        1   |             
      Follicular Cell, Hyperplasia         | 1  2     1  2              1  1  2              1  1     1  2        2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +        +  +  +  +  +                       +  +     +                  |             
      Inflammation, Subacute               |                      1                                                   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                         +     +        +                 +  +            |             
      Inflammation, Subacute               |                               3                          3  3            |             
      Duct, Cyst                           |                         2                                   2            |             
                                            __________________________________________________________________________|             
   Prostate                                | +        +  +  +  +  +                       +  +     +                  |             
      Inflammation, Subacute               |                      3                                                   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +        +  +  +  +  +                       +  +     +                  |             
      Dilatation                           |                                                                          |             
      Inflammation, Subacute               |                      4                                                   |             
                                            __________________________________________________________________________|             
   Testes                                  | +        +  +  +  +  +                       +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +  +  +  +                       +  +     +                  |             
      Hyperplasia, Histiocytic             |                   2                                                      |             
      Myeloid Cell, Hypercellularity       | 1                    2                          2                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +  +  +  +           +           +  +  +  +                  |             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                      2                                                   |             
      Inguinal, Hyperplasia, Lymphoid      |                                                 2  2                     |             
      Mesenteric, Angiectasis              | 2                                                     2                  |             
      Renal, Hyperplasia, Lymphoid         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +  +  M  +  M                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2        2              2           3           2                        |             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |    2           1  1     1  1           1  1        1     1  1  1  1  1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +  +  +  +  +                       +  +     +                  |             
      Necrosis                             |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M        M  M  +  M  M                       M  M     M                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Subacute        |          2                                      3     2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 3| 5| 4| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 6| 5| 7| 2| 6| 3| 3| 3| 3| 3| 3| 3| 7| 2| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 1| 2| 8| 2| 1| 9| 1| 1| 1| 1| 1| 1| 1| 9| 4| 1| 3| 1| 2| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |          2                                   2  4                        |             
      Epidermis, Hyperplasia, Focal        |          2                                                               |             
      Subcutaneous Tissue, Fibrosis, Focal |                                           3  2  3        2               |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +  +  +  +                       +  +     +                  |             
      Hemorrhage                           |                2                                                         |             
      Mineralization, Multifocal           | 1        1  1  2  1  1                          1     1                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +  +  +  +              +     +  +  +     +                 +|             
      Alveolar Epithelium, Hyperplasia     |                   3                             3                       2|             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +  +  +  +                       +  +     +                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +  +  +  +                       +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |             3                                                            |             
      Inflammation, Chronic, Focal         |                      2                                                   |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy, Chronic                 | 1  1  1  1  1     1     3  1  2  1  1  1  1     1  1  1  1  1  2  2  1  1|             
      Cortex, Cyst                         |                         2  1           1                                 |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Hyperplasia            |                         1  1              1                              |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                                              2                           |             
      Renal Tubule, Epithelium, Cytomegaly | 1  2  2  2  2  2  2  1  3  3  2  2  2  1  2     3  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |             +                                                            |             
      Bulbourethral Gland, Hemorrhage      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +  +  +  +                       +  +     +                  |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 4| 3| 3| 5| 4| 2| 3| 3| 2| 3| 3| 3| 8| 9| 3| 3| 3| 3| 7| 3| 9|             
                                           | 2| 6| 2| 0| 1| 2| 2| 3| 2| 9| 2| 2| 1| 2| 2| 2| 5| 7| 2| 2| 2| 2| 0| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +     A  +        +  +           +           A  +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     A  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     A  +        +  +           +           A  +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     A  +        +  +           +           A  +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     A  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     A  +        +  +     +     +           A  +        +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     A  +        +  +           +           A  +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     A  +        +  +     +     +           A  +              +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     A  A        +  +           +           A  +        +     +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                X         |             
      Cytologic Alterations                | 1     1     1  2  1     1  1  2  1     1  2  1     1  2  1  2  2     2  2|             
      Hematopoietic Cell Proliferation     |                                                             2           2|             
      Inflammation, Granulomatous          |                2                          2                              |             
      Inflammation, Multifocal, Subacute   |                                                                          |             
      Mixed Cell Focus                     |                                                             X            |             
      Necrosis, Focal                      |                         3                                                |             
      Kupffer Cell, Pigmentation           | 2     1        2        1  1  2        1  3  1     1  2  1  1  2        1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +  +                  |             
      Fat, Necrosis, Focal                 |                                                    2  3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     A  +        +  +           +           A  +     +        +     +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  A  +        +  +           +     +     +  +     +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  A  +        +  +           +     +     +  +     +        +     +|             
      Erosion                              |       2                                   2                              |             
      Hyperplasia                          |       2                                   2              2               |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     A  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                 +  +                          +                     |             
      Dysplasia                            |    1                 3  2                          4                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +        +  +           +           +  +              +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +  +        +  +           +           +  +              +     +|             
      Spindle Cell, Hyperplasia            |                      3                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +  +        +  +           M           +  +              +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     A  +        +  +           +           A  +              +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +  +        +  +           M           M  +              +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +        +  +           +           M  +              +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 4| 3| 3| 5| 4| 2| 3| 3| 2| 3| 3| 3| 8| 9| 3| 3| 3| 3| 7| 3| 9|             
                                           | 2| 6| 2| 0| 1| 2| 2| 3| 2| 9| 2| 2| 1| 2| 2| 2| 5| 7| 2| 2| 2| 2| 0| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       | 1     1           2     1  1           1                       1     1   |             
      Follicular Cell, Hyperplasia         | 2     1           1     1  1  1  1     1  1                    2     2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +     +  +        +  +           +           +  +              +     +|             
      Inflammation, Subacute               |                                     3                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +  +                                 |             
      Inflammation, Subacute               |                                     4                                    |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +     A  +  +     +  +           +           +  +              +     +|             
      Inflammation, Subacute               |                                                                   2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +     +  +        +  +           +           A  +              +     +|             
      Dilatation                           |                                                                   3      |             
      Inflammation, Subacute               |                                                                   2      |             
                                            __________________________________________________________________________|             
   Testes                                  |    +     +  +        +  +           +           +  +              +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
      Leukocytosis                         |    3                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +        +  +           +           +  +              +     +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Myeloid Cell, Hypercellularity       |                                     3                                   3|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +     +  +  +  +     +           +  +        +     +     +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                         3|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                     2                                    |             
      Mesenteric, Angiectasis              |       3                 2                                                |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                            2              2           2     2  2        4|             
      Hemorrhage                           |    3                                                                     |             
      Pigmentation                         | 1     1              1  1        1     1     1     1     1           1   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +        +  +           +           +  +              +     +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M     M  M        M  M           M           M  M              M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Focal, Subacute        |             2                                                           3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 3| 4| 3| 3| 5| 4| 2| 3| 3| 2| 3| 3| 3| 8| 9| 3| 3| 3| 3| 7| 3| 9|             
                                           | 2| 6| 2| 0| 1| 2| 2| 3| 2| 9| 2| 2| 1| 2| 2| 2| 5| 7| 2| 2| 2| 2| 0| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                 3                        |             
      Epidermis, Hyperplasia, Focal        |                                     2              2                     |             
      Subcutaneous Tissue, Fibrosis, Focal |          3  2                 1                    2                     |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |                                     2                                    |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +        +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +        +  +           +           +  +              +     +|             
      Hemorrhage                           |                                                                          |             
      Mineralization, Multifocal           |    1     2  1           1                          1              1     1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +           +     +     +  +              +     +|             
      Alveolar Epithelium, Hyperplasia     |                                                                   3      |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +  +  +     +  +           +           +  +              +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +        +  +           +           +  +              +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Suppurative            |                                                                   2      |             
      Nephropathy, Chronic                 | 2     3     1  1  1  1  3  1  1  2  1  1  3  2        1  2  1  3     1  1|             
      Cortex, Cyst                         |                                           2                              |             
      Papilla, Necrosis                    |                                                                   2      |             
      Renal Tubule, Hyperplasia            |                   1                          1     1  1                  |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |          2  2           2                       2                        |             
      Renal Tubule, Epithelium, Cytomegaly | 2  2  3     1  2  2  1  3  1  2  2  1  2  3  2     1  2  2  2  3  2  2  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |             +           +                                                |             
      Bulbourethral Gland, Hemorrhage      |             2           3                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     A  +        +  +           +           +  +              +     +|             
      Inflammation, Subacute               |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 6| 6| 6| 7| 6| 7| 6| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus                     |                                                                          |      3     |
      Cytologic Alterations                |                                                                          |     41  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Inflammation, Granulomatous          |                                                                          |     10  1.4|
      Inflammation, Multifocal, Subacute   |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Focal                      |                                                                          |      2  2.5|
      Kupffer Cell, Pigmentation           |                                                                          |     30  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Necrosis, Focal                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  22        |
      Erosion                              |                                                                          |      3  2.0|
      Hyperplasia                          |                                                                          |      5  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
      Dysplasia                            |                                                                          |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  19        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  19        |
      Spindle Cell, Hyperplasia            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 6| 6| 6| 7| 6| 7| 6| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  17        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Follicle, Cyst                       |                                                                          |     19  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |     24  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  19        |
      Inflammation, Subacute               |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   7        |
      Inflammation, Subacute               |                                                                          |      4  3.3|
      Duct, Cyst                           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  19        |
      Inflammation, Subacute               |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  18        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  19        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Leukocytosis                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  19        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Myeloid Cell, Hypercellularity       |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  26        |
      Axillary, Hyperplasia, Lymphoid      |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      3  2.0|
      Mesenteric, Angiectasis              |                                                                          |      4  2.3|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 6| 6| 6| 7| 6| 7| 6| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                                                          |     11  2.3|
      Hemorrhage                           |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |     23  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  19        |
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  45        |
      Inflammation, Focal, Subacute        |                                                                          |      5  2.4|
      Ulcer                                |                                                                          |      4  2.8|
      Epidermis, Hyperplasia, Focal        |                                                                          |      3  2.0|
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |      8  2.3|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Subacute                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  19        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization, Multifocal           |                                                                          |     15  1.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  26        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  19        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Hydronephrosis                       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 9| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 6| 6| 6| 7| 6| 7| 6| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |                                                                          |     42  1.4|
      Cortex, Cyst                         |                                                                          |      4  1.5|
      Papilla, Necrosis                    |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      7  1.0|
      Renal Tubule, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                          |      5  2.0|
      Renal Tubule, Epithelium, Cytomegaly |                                                                          |     47  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   3        |
      Bulbourethral Gland, Hemorrhage      |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  18        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 3| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 2| 2| 7| 7| 1| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 1| 2| 3| 3| 3| 3| 3| 2| 7| 3| 0| 3| 0| 3| 5| 2| 8| 3| 3| 8| 9| 3| 3| 7|             
                                           | 2| 6| 2| 2| 2| 2| 6| 2| 9| 9| 2| 3| 5| 4| 5| 3| 8| 3| 5| 5| 0| 5| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  M           A        +     +     +     +  A  M        M  M        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +           +        +     +     +     +  A  +        +  A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +           A        +     +     +     +  A  +        +  A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +           +        +     +     +     +  A  +        +  A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +           +        +     +     +     +  A  +        +  A        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +           +        +     +     +     +  A  +        +  A        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +           A        +     +     +     +  A  +        +           M|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +           +        +     +     +     M  A  +        +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +           +        +     +     +     +  A  +        +           +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Angiectasis                          |                1                                                         |             
      Basophilic Focus                     |                                                       X                  |             
      Cytologic Alterations                | 1        1  1  1     1  1     1  2           1           1        1  1   |             
      Eosinophilic Focus                   |             X                                            X           X   |             
      Inflammation, Granulomatous          |                                                          1               |             
      Mixed Cell Focus                     |                X                                                         |             
      Necrosis, Focal                      |                      1                                                   |             
      Centrilobular, Necrosis              |                                                                          |             
      Kupffer Cell, Pigmentation           |                                  2                       1               |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Cyst                                 |                                                                          |             
      Fat, Necrosis, Focal                 |             3                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +           +        +     +     +     +  +  +        +  A        +|             
      Acinus, Atrophy, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +           A        +     +     +     +  +  +  +     +  A        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +           A        +     +     +     +  +  +  +     +  A        +|             
      Hyperplasia                          |                                                       2                  |             
      Inflammation, Subacute               |                                                       2     2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +           A        +     +     +     +  +  +  +     +  A        +|             
      Erosion                              |                            2                                             |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                 +                           |             
      Dysplasia                            |                            1                 2                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +                                             |             
      Abdominal, Inflammation, Subacute    |                            2                                             |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +           +        +     +     +     +  +  +        +  +        +|             
      Inflammation, Subacute               |                            2                                             |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 3| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 2| 2| 7| 7| 1| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 1| 2| 3| 3| 3| 3| 3| 2| 7| 3| 0| 3| 0| 3| 5| 2| 8| 3| 3| 8| 9| 3| 3| 7|             
                                           | 2| 6| 2| 2| 2| 2| 6| 2| 9| 9| 2| 3| 5| 4| 5| 3| 8| 3| 5| 5| 0| 5| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +           +        +  +  +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +           +        +  +  +     +     +  +  +        +  +        +|             
      Cyst                                 |                               2                                          |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +           +        +     +     +     +  +  +        +  +        +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +           +        +     +     +     +  +  M        M  M        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  I           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |             2        1                                                   |             
      Follicular Cell, Hyperplasia         | 1           2  1              2     1                                1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +           +        +     +     +     +  +  +        +  +        +|             
      Granuloma Sperm                      |                                              2                           |             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                         +                 +         |             
      Developmental Malformation           |    X                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +  +  +  +     +     +     +        +           +               |             
      Inflammation, Subacute               |                2  4     3     3     2        4           2               |             
      Duct, Cyst                           |          2        2           2                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +           +        +     +     +     +  +  +        +  +        +|             
      Hemorrhage                           |                                                 4                        |             
      Inflammation, Subacute               |       4                    2                    4  3        3  2         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +           +        +     +     +     +  +  +        +  +        +|             
      Inflammation, Subacute               |                                                             2            |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +           +        +     +     +     +  +  +        +  +        +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +           +        +     +     +     +  +  +        +  +        +|             
      Myeloid Cell, Hypercellularity       |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +        +     +  +     +     +     +  +  +     +  +  +        +|             
      Inguinal, Hyperplasia, Lymphoid      |                   3                                3                     |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mesenteric, Angiectasis              |                            2           1                 2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  M           +        +     +     +     +  +  +        +  +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 3| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 2| 2| 7| 7| 1| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 1| 2| 3| 3| 3| 3| 3| 2| 7| 3| 0| 3| 0| 3| 5| 2| 8| 3| 3| 8| 9| 3| 3| 7|             
                                           | 2| 6| 2| 2| 2| 2| 6| 2| 9| 9| 2| 3| 5| 4| 5| 3| 8| 3| 5| 5| 0| 5| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A|             
      Atrophy                              |                            3                                             |             
      Hematopoietic Cell Proliferation     |       2              3        2  2                                       |             
      Pigmentation                         |                            1                                      1      |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +           +        +     M     +     +  +  +        +  M        +|             
      Atrophy                              |                            2                                             |             
      Necrosis                             |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M           M        M     M     M     M  M  M        M  M        M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Inflammation, Focal, Subacute        |       3           2        2                       3     2               |             
      Ulcer                                |       3                 2                       2  3                     |             
      Epidermis, Hyperplasia, Focal        |                                                                          |             
      Epidermis, Hyperplasia               |          1                                                               |             
      Subcutaneous Tissue, Fibrosis, Focal |       3                                         3  3                     |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +           +        +     +     +     +  +  +        +  +        +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +           +        +     +     +     +  +  +        +  +        +|             
      Mineralization, Multifocal           |       1                    1     1     1     1                          1|             
      Necrosis, Multifocal                 |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +           +        +     +     +     +  +  +        +  +        +|             
      Congestion                           |                                                    3                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +           +        +     +     +     +  +  +        +  +        +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +           +        +     +     +     +  +  +        +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +  +     +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                3         |             
      Inflammation, Suppurative            |                                                             3            |             
      Nephropathy, Chronic                 | 2        2  1  1     1  1  1  2  1     1  1  1  1     1  2        1  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 3| 7| 7| 7| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 2| 2| 7| 7| 1| 2| 7| 7| 5|             
                             DAY ON TEST   | 3| 1| 2| 3| 3| 3| 3| 3| 2| 7| 3| 0| 3| 0| 3| 5| 2| 8| 3| 3| 8| 9| 3| 3| 7|             
                                           | 2| 6| 2| 2| 2| 2| 6| 2| 9| 9| 2| 3| 5| 4| 5| 3| 8| 3| 5| 5| 0| 5| 5| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation                 |                            2                                             |             
      Cortex, Cyst                         |                               2                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       | 1  1  1                                                     1            |             
      Renal Tubule, Epithelium, Cytomegaly | 1  1     2  2  1     1  1  1  2  2  1  1  1  1        1  2        1  1   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                    +                     |             
      Dilatation                           |                                                    3                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +           +        +     +     +  +  +  +  +        +  +        +|             
      Hemorrhage                           |       2                                         4                        |             
      Inflammation, Subacute               |                            2                                3            |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 3| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 1| 8| 0| 4| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 8| 3| 2| 8| 3| 3|             
                                           | 0| 5| 5| 5| 2| 8| 2| 8| 0| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| 9| 8| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +           +  +  +  +  +  +                       +     +        +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +           +  +  +  +  +  +                       M     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     +  +  +  +  +  +                       A     +        +      |             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                            X                                             |             
      Cytologic Alterations                |                            1     1     1     1  1     1     1  1        2|             
      Eosinophilic Focus                   |                                                             X            |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |          X                                            X                  |             
      Necrosis, Focal                      |                                                 2        3               |             
      Centrilobular, Necrosis              |                      1                                                   |             
      Kupffer Cell, Pigmentation           |                                              1  1                       1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                   +               |             
      Cyst                                 |                                                          3               |             
      Fat, Necrosis, Focal                 |                      3                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +  +  +  +  +  +                       A     +        +      |             
      Acinus, Atrophy, Multifocal          |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +  +  +  +  +  +                       +     +        +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +           +  +  +  +  +  +                       A     +     +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +           +  +  +  +  +  +                       A     +     +  +      |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +           +  +  +  +  +  +                       A     +        +      |             
      Erosion                              |                                                                          |             
      Inflammation, Subacute               |                            2                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
      Dysplasia                            |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Abdominal, Inflammation, Subacute    |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +           +  +  +  +  +  +                       +     +        +      |             
      Inflammation, Subacute               |                                                                          |             
      Atrium, Thrombosis                   |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 3| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 1| 8| 0| 4| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 8| 3| 2| 8| 3| 3|             
                                           | 0| 5| 5| 5| 2| 8| 2| 8| 0| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| 9| 8| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +           +  +  +  +  +  +                       +     +        +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +           +  +  +  +  +  +                       +     +        +      |             
      Cyst                                 |                                                                          |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |             2                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +           +  +  +  +  +  +                       M     +        +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +  +  +  +  +  +                       +     +        +      |             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +           +  +  +  +  +  +                       +     +        +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +  +  +  +  +  +                       M     +        +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |    1                                                           1         |             
      Follicular Cell, Hyperplasia         |    2     1                                                     1     1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +           +  +  +  +  +  +                       +     +        +      |             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +        +                 +        +           +                  |             
      Inflammation, Subacute               |       3                          2                    2                  |             
      Duct, Cyst                           |                                  2        2           2                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +           +  +  +  +  +  +                       +     +        +      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Subacute               |                                                    3                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +           +  +  +  +  +  +                       A     +        +      |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +           +  +  +  +  +  +                       +     +        +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                   +      |             
      Leukocytosis                         |                                                                   X      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +           +  +  +  +  +  +                       +     +        +      |             
      Myeloid Cell, Hypercellularity       |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +  +  +  +  +  +  +                    +     +     +  +      |             
      Inguinal, Hyperplasia, Lymphoid      |                2              3                                          |             
      Mediastinal, Hyperplasia, Lymphoid   | 3                                                                        |             
      Mesenteric, Angiectasis              |                         2  2                                   1  1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +           M  +  +  +  +  +                       M     +        M      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 3| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 1| 8| 0| 4| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 8| 3| 2| 8| 3| 3|             
                                           | 0| 5| 5| 5| 2| 8| 2| 8| 0| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| 9| 8| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          1               |             
      Hematopoietic Cell Proliferation     |                      4     3     1                             2        2|             
      Pigmentation                         |          1  1  1        1                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | M           +  +  +  +  +  +                       M     +        +      |             
      Atrophy                              |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M           M  M  M  M  M  M                       M     M        M      |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +        +              +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Subacute        |                3                                      2                 2|             
      Ulcer                                |                2  3                                                      |             
      Epidermis, Hyperplasia, Focal        | 2     2                                               2                 2|             
      Epidermis, Hyperplasia               |                                                                          |             
      Subcutaneous Tissue, Fibrosis, Focal |                   3                                   2           2      |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +           +  +  +  +  +  +                       +     +        +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +           +  +  +  +  +  +                       +     +        +      |             
      Mineralization, Multifocal           | 1                    1  1  1                                      1      |             
      Necrosis, Multifocal                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +  +  +  +  +                       +  +  +        +      |             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      | 4                                                     3                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +           +  +  +  +  +  +                       A     +        +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +           +  +  +  +  +  +                       +     +        +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy, Chronic                 | 1  1  1  1  2        1  2  1  2  2  2  1  1  2  1     1  1  1  2  1  1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 3| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 1| 8| 0| 4| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 8| 3| 2| 8| 3| 3|             
                                           | 0| 5| 5| 5| 2| 8| 2| 8| 0| 3| 5| 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| 9| 8| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.25%                                  | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Cortex, Cyst                         |                                              2                           |             
      Renal Tubule, Hyperplasia            |                                           1                              |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                2  2                                                      |             
      Renal Tubule, Epithelium, Cytomegaly | 1  1  1  1  2  1        1  1  2  2  2  2  1  2  1     1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Urethra                                 |                +                                                         |             
      Dilatation                           |                                                                          |             
      Inflammation, Suppurative            |                3                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +  +  +  +  +  +                       A     +        +      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 6| 7| 6| 7| 7| 6| 7| 7| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  18        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  48        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                          |      2     |
      Cytologic Alterations                |                                                                          |     21  1.1|
      Eosinophilic Focus                   |                                                                          |      4     |
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      3     |
      Necrosis, Focal                      |                                                                          |      3  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  1.0|
      Kupffer Cell, Pigmentation           |                                                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Cyst                                 |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  20        |
      Acinus, Atrophy, Multifocal          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  21        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  21        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  20        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
      Dysplasia                            |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 6| 7| 6| 7| 7| 6| 7| 7| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Abdominal, Inflammation, Subacute    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  22        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  23        |
      Cyst                                 |                                                                          |      1  2.0|
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  21        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  22        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
      Follicle, Cyst                       |                                                                          |      4  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |     10  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  22        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   3        |
      Developmental Malformation           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  14        |
      Inflammation, Subacute               |                                                                          |     10  2.7|
      Duct, Cyst                           |                                                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  22        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Subacute               |                                                                          |      7  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  21        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  22        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 6| 7| 6| 7| 7| 6| 7| 7| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Leukocytosis                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  22        |
      Myeloid Cell, Hypercellularity       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  27        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      4  2.8|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mesenteric, Angiectasis              |                                                                          |      7  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  47        |
      Atrophy                              |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      9  2.3|
      Pigmentation                         |                                                                          |      6  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  18        |
      Atrophy                              |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  39        |
      Inflammation, Focal, Subacute        |                                                                          |      8  2.4|
      Ulcer                                |                                                                          |      6  2.5|
      Epidermis, Hyperplasia, Focal        |                                                                          |      4  2.0|
      Epidermis, Hyperplasia               |                                                                          |      1  1.0|
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |      6  2.7|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  22        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  22        |
      Mineralization, Multifocal           |                                                                          |     11  1.0|
      Necrosis, Multifocal                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  25        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05019-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:26  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 7| 6| 7| 6| 7| 7| 6| 7| 7| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.25%                                  | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                                                                          |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  21        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  22        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Nephropathy, Chronic                 |                                                                          |     39  1.3|
      Artery, Inflammation                 |                                                                          |      1  2.0|
      Cortex, Cyst                         |                                                                          |      2  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Renal Tubule, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                          |      6  1.3|
      Renal Tubule, Epithelium, Cytomegaly |                                                                          |     40  1.3|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  22        |
      Hemorrhage                           |                                                                          |      2  3.0|
      Inflammation, Subacute               |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.