National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3389

TDMS Study 05019-03 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          CI PIGMENT RED 3


NTP Experiment-Test: 05019-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: DOSED FEED                                                                                                 Time: 14:37:35




       Facility:  Southern Research Institute

       Chemical CAS #:  2425-85-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05019-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          15            7            8            7                                     
    Dead                                               3            2            3            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           40           39           40                                     
    Dead                                                            1                                                               
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (9)          (12)         (50)                                   
      Sarcoma, Metastatic, Uterus                                                1 (8%)                                             
   Intestine Large, Rectum                            (50)         (10)         (12)         (50)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Small, Duodenum                          (50)         (10)         (11)         (49)                                   
      Sarcoma, Metastatic, Uterus                                                1 (9%)                                             
   Intestine Small, Jejunum                           (48)         (9)          (9)          (49)                                   
      Sarcoma, Metastatic, Uterus                                                1 (11%)                                            
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                                                     1 (2%)       9 (18%)                               
      Hepatocellular Adenoma, Multiple                                                        1 (2%)                                
   Mesentery                                          (6)          (6)          (10)         (4)                                    
      Adenocarcinoma, Metastatic, Uterus               1 (17%)                                                                      
      Sarcoma, Metastatic, Uterus                                                1 (10%)                                            
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Sarcoma, Metastatic, Uterus                                                1 (2%)                                             
   Pharynx                                                         (2)          (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
      Squamous Cell Papilloma                                       1 (50%)                                                         
   Stomach, Forestomach                               (50)         (9)          (12)         (50)                                   
      Sarcoma, Metastatic, Uterus                                                1 (8%)                                             
   Stomach, Glandular                                 (50)         (9)          (12)         (50)                                   
      Sarcoma, Metastatic, Uterus                                                1 (8%)                                             
   Tongue                                                                       (2)                                                 
      Squamous Cell Carcinoma                                                    2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05019-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (12)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (16)         (13)         (50)                                   
      Adenoma                                          2 (4%)       1 (6%)                                                          
      Hemangiosarcoma                                                                         1 (2%)                                
      Capsule, Sarcoma, Metastatic, Uterus                                       1 (8%)                                             
   Adrenal Gland, Medulla                             (49)         (16)         (13)         (50)                                   
      Pheochromocytoma Malignant                                    1 (6%)                                                          
      Pheochromocytoma Complex                         1 (2%)                    1 (8%)                                             
      Pheochromocytoma Benign                          4 (8%)       3 (19%)                   4 (8%)                                
   Islets, Pancreatic                                 (49)         (50)         (50)         (49)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (50)         (22)         (20)         (50)                                   
      Pars Distalis, Adenoma                          23 (46%)     13 (59%)     11 (55%)     21 (42%)                               
      Pars Distalis, Adenoma, Multiple                                           1 (5%)                                             
      Pars Distalis, Adenoma, Multiple, Two            2 (4%)                                 1 (2%)                                
      Pars Distalis, Carcinoma                                                   1 (5%)                                             
   Thyroid Gland                                      (50)         (12)         (13)         (50)                                   
      C-Cell, Adenoma                                  6 (12%)      1 (8%)       1 (8%)       6 (12%)                               
      C-Cell, Carcinoma                                1 (2%)       2 (17%)      1 (8%)                                             
      Follicular Cell, Adenoma                         1 (2%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (14)         (14)         (50)                                   
      Adenoma                                          9 (19%)      1 (7%)                    1 (2%)                                
   Ovary                                              (50)         (14)         (14)         (50)                                   
      Leiomyosarcoma                                                1 (7%)                                                          
   Uterus                                             (50)         (23)         (28)         (50)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
      Adenoma                                          1 (2%)                                                                       
      Fibroma                                          1 (2%)                                                                       
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Leiomyoma                                                                               1 (2%)                                
      Leiomyosarcoma                                                             1 (4%)       1 (2%)                                
                                                             Page   3                                                               
NTP Experiment-Test: 05019-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Polyp Stromal                                    9 (18%)      7 (30%)      5 (18%)      9 (18%)                               
      Polyp Stromal, Multiple, Two                     1 (2%)                    1 (4%)       1 (2%)                                
      Sarcoma                                                                    1 (4%)                                             
      Sarcoma Stromal                                  1 (2%)                                 1 (2%)                                
   Vagina                                             (7)                       (5)          (1)                                    
      Sarcoma                                                                    1 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (12)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Iliac, Adenocarcinoma, Metastatic, Uterus        1 (2%)                                                                       
      Mesenteric, Sarcoma, Metastatic, Uterus                                    1 (2%)                                             
      Renal, Adenocarcinoma, Metastatic, Uterus        1 (2%)                                                                       
   Lymph Node, Mandibular                             (50)         (50)         (50)         (49)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Sarcoma                                                                                 1 (2%)                                
   Thymus                                             (49)         (11)         (12)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Adenocarcinoma                                   3 (6%)       1 (2%)                                                          
      Adenocarcinoma, Multiple                         1 (2%)                                                                       
      Adenoma                                                                                 1 (2%)                                
      Fibroadenoma                                    15 (30%)     13 (26%)     16 (33%)     11 (22%)                               
      Fibroadenoma, Multiple                           8 (16%)      3 (6%)       4 (8%)       1 (2%)                                
      Myoepithelioma                                                             1 (2%)                                             
   Skin                                               (50)         (26)         (33)         (50)                                   
      Keratoacanthoma                                  2 (4%)                                                                       
      Trichoepithelioma                                1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                  1 (4%)       1 (3%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (4%)       1 (3%)                                             
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (15)         (16)         (50)                                   
      Vertebra, Coccygeal, Chordoma                                 1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05019-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (13)         (50)                                   
      Astrocytoma Malignant                                                      1 (8%)                                             
      Carcinoma, Metastatic, Pituitary Gland                                     1 (8%)                                             
      Ependymoma Malignant                                                       2 (15%)                                            
      Glioma Malignant                                 1 (2%)                                                                       
      Oligodendroglioma Malignant                                   1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                 2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                                             2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Lipoma                                           1 (2%)                                                                       
   Urinary Bladder                                    (50)         (10)         (12)         (50)                                   
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leukemia Mononuclear                            10 (20%)      1 (2%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05019-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          35          38          41                                       
     Total Primary Neoplasms                          109          55          57          79                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44          31          32          38                                       
     Total Benign Neoplasms                            88          45          42          72                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          10          14           7                                       
     Total Malignant Neoplasms                         21          10          15           7                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           2                                                   
     Total Metastatic Neoplasm                          6           1          10                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05019-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9            9            9                                     
  Early Deaths                                                                                                                      
    Moribund                                          17            7           16           26                                     
    Dead                                               5            4            7            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           40           28           20                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (10)         (19)         (50)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Large, Colon                             (50)         (10)         (22)         (50)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Polyp Adenomatous                                                          1 (5%)                                             
   Intestine Small, Duodenum                          (50)         (9)          (21)         (50)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Intestine Small, Ileum                             (50)         (9)          (19)         (49)                                   
   Intestine Small, Jejunum                           (50)         (10)         (20)         (49)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Multiple, Metastatic, Two, Kidney                                            1 (2%)                                
      Hepatocellular Carcinoma                                                   1 (2%)                                             
      Hepatocellular Adenoma                                        1 (2%)       3 (6%)       1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Mesentery                                          (11)         (6)          (6)          (6)                                    
      Carcinoma, Multiple, Metastatic, Greater                                                                                      
          Than Five, Kidney                                                                   1 (17%)                               
      Fibrosarcoma, Metastatic, Spleen                 1 (9%)                                                                       
      Hemangiosarcoma                                                            1 (17%)                                            
      Osteosarcoma, Metastatic, Bone                                                          1 (17%)                               
   Oral Mucosa                                                     (1)                                                              
      Gingival, Squamous Cell Carcinoma                             1 (100%)                                                        
   Pancreas                                           (50)         (50)         (49)         (50)                                   
      Carcinoma, Multiple, Metastatic, Two, Kidney                                            1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Acinar Cell, Adenoma                             1 (2%)       1 (2%)                                                          
   Salivary Glands                                    (50)         (10)         (22)         (50)                                   
   Stomach, Forestomach                               (50)         (10)         (22)         (49)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Squamous Cell Carcinoma                                                    1 (5%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05019-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Glandular                                 (50)         (10)         (22)         (49)                                   
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (11)         (27)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (4%)                                             
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)         (50)                                   
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Capsule, Carcinoma, Multiple, Metastatic,                                                                                     
           Two, Kidney                                                                        1 (2%)                                
      Capsule, Osteosarcoma, Metastatic, Bone                                                 1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       6 (12%)      7 (14%)      9 (18%)      3 (6%)                                
      Pheochromocytoma Malignant, Multiple                                       1 (2%)       1 (2%)                                
      Pheochromocytoma Benign                         16 (32%)     11 (22%)     20 (40%)     22 (44%)                               
      Pheochromocytoma Benign, Multiple                6 (12%)     18 (36%)     15 (30%)     12 (24%)                               
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Adenoma                                          5 (10%)                   2 (4%)                                             
      Adenoma, Multiple                                                          1 (2%)                                             
   Pituitary Gland                                    (50)         (16)         (25)         (50)                                   
      Pars Distalis, Adenoma                          17 (34%)      9 (56%)      8 (32%)     12 (24%)                               
      Pars Distalis, Carcinoma                                      1 (6%)                                                          
      Pars Distalis, Carcinoma, Metastatic,                                                                                         
          Zymbal's Gland                                                         1 (4%)                                             
      Pars Intermedia, Carcinoma, Metastatic,                                                                                       
          Zymbal's Gland                                                         1 (4%)                                             
      Pars Nervosa, Carcinoma, Metastatic,                                                                                          
          Zymbal's Gland                                                         1 (4%)                                             
   Thyroid Gland                                      (50)         (11)         (23)         (50)                                   
      C-Cell, Adenoma                                  4 (8%)                                 4 (8%)                                
      C-Cell, Carcinoma                                2 (4%)       1 (9%)                    1 (2%)                                
      Follicular Cell, Adenoma                                                                1 (2%)                                
      Follicular Cell, Adenoma, Cystic                 1 (2%)                                                                       
      Follicular Cell, Adenoma, Cystic, Papillary                                1 (4%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                    1 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05019-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (10)         (23)         (50)                                   
   Preputial Gland                                    (49)         (13)         (25)         (50)                                   
      Adenoma                                          6 (12%)                   1 (4%)       1 (2%)                                
      Carcinoma                                        1 (2%)                                                                       
   Prostate                                           (50)         (10)         (22)         (50)                                   
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
   Seminal Vesicle                                    (50)         (11)         (22)         (50)                                   
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Testes                                             (50)         (49)         (48)         (50)                                   
      Interstitial Cell, Adenoma                       6 (12%)     12 (24%)      6 (13%)     12 (24%)                               
      Interstitial Cell, Adenoma, Multiple            41 (82%)     35 (71%)     39 (81%)     37 (74%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (22)         (49)                                   
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Axillary, Basosquamous Tumor Malignant,                                                                                       
          Metastatic, Skin                                                       1 (2%)                                             
      Axillary, Osteosarcoma, Metastatic, Bone                                   1 (2%)                                             
      Mediastinal, Basosquamous Tumor Malignant,                                                                                    
           Metastatic, Skin                                                      1 (2%)                                             
      Mediastinal, Carcinoma, Multiple, Metastatic,                                                                                 
           Two, Kidney                                                                        1 (2%)                                
      Pancreatic, Squamous Cell Carcinoma,                                                                                          
          Metastatic, Stomach                                                    1 (2%)                                             
   Lymph Node, Mandibular                             (48)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Carcinoma, Multiple, Metastatic, Two, Kidney                                            1 (2%)                                
      Fibrosarcoma                                     1 (2%)                                 1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       2 (4%)       1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Thymus                                             (44)         (10)         (19)         (49)                                   
      Epithelial Cell, Thymoma Benign                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05019-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (13)         (24)         (48)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
      Fibroadenoma                                     2 (4%)                    1 (4%)       2 (4%)                                
      Fibroadenoma, Multiple                           1 (2%)                                                                       
   Skin                                               (50)         (31)         (47)         (50)                                   
      Basal Cell Adenoma                               1 (2%)       2 (6%)       1 (2%)                                             
      Basosquamous Tumor Malignant                                               1 (2%)                                             
      Carcinoma                                        1 (2%)                                                                       
      Keratoacanthoma                                  2 (4%)                    2 (4%)       2 (4%)                                
      Squamous Cell Papilloma                                       4 (13%)      2 (4%)       6 (12%)                               
      Trichoepithelioma                                1 (2%)       1 (3%)                                                          
      Subcutaneous Tissue, Fibroma                     4 (8%)                    2 (4%)       4 (8%)                                
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       2 (6%)                                                          
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Osteosarcoma                1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Benign                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)         (22)         (50)                                   
      Osteosarcoma                                                               1 (5%)       1 (2%)                                
   Skeletal Muscle                                                 (1)                       (1)                                    
      Diaphragm, Osteosarcoma, Metastatic, Bone                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (22)         (50)                                   
      Astrocytoma Malignant                            1 (2%)                    1 (5%)                                             
      Carcinoma, Multiple, Metastatic, Greater                                                                                      
          Than Five, Zymbal's Gland                                              1 (5%)                                             
      Carcinoma, Metastatic, Pituitary Gland                        1 (9%)                                                          
      Glioma Malignant                                                           1 (5%)                                             
      Meningioma Malignant                                          1 (9%)                                                          
   Spinal Cord                                                     (1)                                                              
      Chordoma                                                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  2 (4%)                    2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    1 (2%)                                             
      Basosquamous Tumor Malignant, Multiple,                                                                                       
                                                             Page  10                                                               
NTP Experiment-Test: 05019-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Metastatic, Greater Than Five, Skin                                    1 (2%)                                             
      Carcinoma, Multiple, Metastatic, Greater                                                                                      
          Than Five, Kidney                                                                   1 (2%)                                
      Carcinoma, Multiple, Metastatic, Greater                                                                                      
          Than Five, Zymbal's Gland                                              1 (2%)       1 (2%)                                
      Chordoma, Metastatic                                          1 (2%)                                                          
      Osteosarcoma, Multiple, Metastatic, Greater                                                                                   
          Than Five, Bone                                                        1 (2%)                                             
      Pheochromocytoma Malignant, Multiple,                                                                                         
          Metastatic, Greater Than Five, Adrenal                                                                                    
          Gland                                                                  1 (2%)                                             
      Schwannoma Malignant, Multiple, Metastatic,                                                                                   
           Three, Ear                                               1 (2%)                                                          
   Nose                                               (50)         (10)         (22)         (50)                                   
      Papilloma                                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (2)                       (2)                                    
      Schwannoma Benign                                                                       2 (100%)                              
      Schwannoma Malignant                                          1 (50%)                                                         
   Zymbal's Gland                                                               (2)          (3)                                    
      Carcinoma                                                                  2 (100%)     3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Carcinoma                                        1 (2%)                                                                       
      Renal Tubule, Adenoma                                         1 (2%)       1 (2%)                                             
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
      Renal Tubule, Oncocytoma Benign                                            1 (2%)                                             
      Transitional Epithelium, Carcinoma                                                      1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            22 (44%)      6 (12%)      2 (4%)       1 (2%)                                
      Mesothelioma Malignant                           3 (6%)       1 (2%)       2 (4%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05019-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          50          50                                       
     Total Primary Neoplasms                          164         122         135         141                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          50          50          49                                       
     Total Benign Neoplasms                           117          98         108         123                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              32          22          22          16                                       
     Total Malignant Neoplasms                         47          24          27          18                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           5           3                                       
     Total Metastatic Neoplasm                          1           3          14          21                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.