National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3393

TDMS Study 05019-03 Pathology Tables

NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97
Route: DOSED FEED                                                                                                 Time: 06:45:21




       Facility:  Southern Research Institute

       Chemical CAS #:  2425-85-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 5| 8| 2| 2| 2| 8| 1| 2| 2| 2| 8| 2| 2| 2| 2| 0| 1| 2| 2| 2|             
                                           | 6| 0| 9| 9| 9| 8| 7| 9| 9| 9| 7| 0| 3| 9| 9| 6| 9| 9| 9| 9| 9| 6| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Parasite Metazoan                    |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       2  2        2        2     2                                2     2|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |    X  X  X  X     X  X  X  X     X     X  X     X  X  X  X     X  X  X  X|             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma, Multiple                  |       1     1        1  1  1        1  1        1        1     3        1|             
      Hepatodiaphragmatic Nodule           |    2                 3                                                   |             
      Mixed Cell Focus                     |                                        X                       X         |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Regeneration                         |                                  1  2        2                    2      |             
      Vacuolization Cytoplasmic, Diffuse   |                               4                             2            |             
      Biliary Tract, Proliferation         | 1  1        1     1     1     1  1  2        2           1     1  2      |             
      Centrilobular, Necrosis              |                               1                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +           +                       +              +            |             
      Fat, Necrosis, Focal                 |          3           2                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                    X                     |             
      Acinus, Atrophy, Multifocal          | 2  2     1           1                    2        2     2     1  1      |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Acinus, Hyperplasia, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |    1     1                 1                                             |             
      Acinus, Atrophy, Multifocal          |                                                                3         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 5| 8| 2| 2| 2| 8| 1| 2| 2| 2| 8| 2| 2| 2| 2| 0| 1| 2| 2| 2|             
                                           | 6| 0| 9| 9| 9| 8| 7| 9| 9| 9| 7| 0| 3| 9| 9| 6| 9| 9| 9| 9| 9| 6| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 1     1  1           1     1        1     1  1  2  1  1  2     1  1  2  2|             
      Inflammation, Focal, Subacute        |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2               |             
      Congestion                           | 1                                                                        |             
      Degeneration, Fatty, Focal           |                            2                          2                 1|             
      Hyperplasia, Focal                   |    2     2           1                    2        2     1           2  1|             
      Hypertrophy, Focal                   |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                         2                 1                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    2                 1        2           1  2                           |             
      Hyperplasia, Multifocal              | 3                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3  2  2  2  2        3           4  3  3     2     4  2  3     4  2     4|             
      Pars Distalis, Cyst                  |    1              2           1  2        1     1  4  2              3   |             
      Pars Distalis, Hyperplasia, Focal    |       2  2        2           1        2     2  3     3           3      |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |       2  2  1        2              2        1        1  1     1  1     1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                            1     2        2           2  1              2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                    3                                3                  |             
      Inflammation, Subacute               |    3        2                          3  2        2  3                  |             
      Duct, Cyst                           | 3  4        2                          3        3  3  3              3  3|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X  X        3                        |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 5| 8| 2| 2| 2| 8| 1| 2| 2| 2| 8| 2| 2| 2| 2| 0| 1| 2| 2| 2|             
                                           | 6| 0| 9| 9| 9| 8| 7| 9| 9| 9| 7| 0| 3| 9| 9| 6| 9| 9| 9| 9| 9| 6| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       2                 2                                3               |             
      Cervix, Abscess                      |       4                                3        4        4               |             
      Cervix, Cyst                         |       4                                3        4        4               |             
      Endometrium, Hyperplasia, Cystic     |                                                                      1   |             
      Mucosa, Cyst                         |                                                                          |             
      Wall, Cervix, Hypertrophy            |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                              +        +  +               |             
      Wall, Hypertrophy                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  2                                                                  |             
      Infiltration Cellular, Histiocyte    |                                        2                                 |             
      Myelofibrosis                        | 4                                            2                           |             
      Pigmentation, Multifocal, Cholesterol|                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Congestion              | 2                                                                        |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 2  1  1  1  1  1  1  1  1  1  2  1  1  1  1     1  1  1  1  1  1  1  1  1|             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 2  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1|             
      Pancreatic, Ectasia                  |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       1  1  1        1     1     1     1     1  1        1     2  1  1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      | 1                                                                 2      |             
      Hematopoietic Cell Proliferation     | 3                                                                        |             
      Hyperplasia, Focal                   |                                        4                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   1     1                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |                                              4                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 2                                                                        |             
      Cranium, Osteopetrosis               |                               3     2                             2      |             
      Femur, Osteopetrosis                 |                               4     2                             2      |             
      Turbinate, Osteopetrosis             |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 5| 8| 2| 2| 2| 8| 1| 2| 2| 2| 8| 2| 2| 2| 2| 0| 1| 2| 2| 2|             
                                           | 6| 0| 9| 9| 9| 8| 7| 9| 9| 9| 7| 0| 3| 9| 9| 6| 9| 9| 9| 9| 9| 6| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                     1                                   2|             
      Hydrocephalus                        |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Granuloma, Multiple                  |                                                                         1|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Histiocyte                       | 2                                                                        |             
      Pleura, Fibrosis, Focal              |                                                                         1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                 2                        |             
      Fungus                               |                                                 3                        |             
      Inflammation, Acute, Suppurative     |                                                 3                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |    1              1              1                 1  1  1        1  2  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                          +     +  +  +  +  +  +  +  +  +               |             
      Cataract                             | 4                          3     4  4  3  2  2  3  2  4  2               |             
      Retina, Degeneration                 | 4                          3     4  4  3  3  4  3  3  4  3               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                             2            |             
      Nephropathy, Chronic                 | 4  3  2  3  2     1  3  1  1  1  1  2  2  1  2  1  2  2  2  1  1  2  2  2|             
      Cortex, Cyst                         |                                                                          |             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     | 1                                                                        |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin, Multifocal          |                                  4           4                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 3| 0| 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 2| 4| 2| 9| 9| 7| 0| 9| 9| 9| 6| 3| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             2           2                    2                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                               2                                          |             
      Basophilic Focus                     |                                     X                                    |             
      Basophilic Focus, Multiple           | X  X     X  X  X     X  X  X  X        X  X        X  X  X  X  X  X  X   |             
      Eosinophilic Focus                   |                                           X                              |             
      Granuloma, Multiple                  | 2  2        1     2     1  3  1     1  1  2  1        2     1     1  1  2|             
      Hepatodiaphragmatic Nodule           |                                        2                       2         |             
      Mixed Cell Focus                     |                                        X                    X            |             
      Necrosis, Focal                      |                         1  1                                             |             
      Necrosis, Multifocal                 |                                                       1                  |             
      Regeneration                         |                                  2              2                        |             
      Vacuolization Cytoplasmic, Diffuse   |                   3  2                                                   |             
      Biliary Tract, Proliferation         |                                  1     1        2     2        1  1      |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                  +               |             
      Fat, Necrosis, Focal                 |       3                                                  4               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Acinus, Atrophy, Multifocal          | 1  1  2  3  1  1              1  2     2  2  1        1     1            |             
      Acinus, Hyperplasia, Focal           |             2                                                     2      |             
      Acinus, Hyperplasia, Multifocal      |                2                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                               2                                          |             
      Acinus, Atrophy, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                     1                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 3| 0| 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 2| 4| 2| 9| 9| 7| 0| 9| 9| 9| 6| 3| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |    1        1  1        1  2     1  1  2     1  2  2  1  3  1  1     1  2|             
      Inflammation, Focal, Subacute        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Degeneration, Fatty, Focal           |    1                       3  2                          2     3         |             
      Hyperplasia, Focal                   | 2     2     1           1  2        1  2                 1     2     2   |             
      Hypertrophy, Focal                   |                               2                             1     1  1   |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                    1                     |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                     1                             2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2  1           1                                         1           1   |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 4     3  3  4  2  4  2        2  4     2  4  3     4  2  4  3     3  4  2|             
      Pars Distalis, Cyst                  |    2  2  2  3  2     2  2  2  2  2  2  2        1  2  4              2  1|             
      Pars Distalis, Hyperplasia, Focal    |    2     3     3           2                 3                 2         |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |       1  1  2     2  1        2  1        2        2  2  2        1  2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                   2                                                      |             
      C-Cell, Hyperplasia, Focal           |                            1                       2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
      Hyperplasia                          |             2                             2        1     1               |             
      Inflammation, Subacute               |       2           3        2                                             |             
      Duct, Cyst                           |    3  2                    3              2        2                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2                                                              1|             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 3| 0| 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 2| 4| 2| 9| 9| 7| 0| 9| 9| 9| 6| 3| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Cervix, Abscess                      |                                     4                                    |             
      Cervix, Cyst                         |                                     4                                    |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
      Mucosa, Cyst                         | 2                          2  2                                          |             
      Wall, Cervix, Hypertrophy            |                                                       3                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +  +                       +        +                  |             
      Wall, Hypertrophy                    |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2              2     2        2        2     2                           |             
      Infiltration Cellular, Histiocyte    |                                                                         1|             
      Myelofibrosis                        |                                                                          |             
      Pigmentation, Multifocal, Cholesterol|                                                                         1|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                2                                                         |             
      Mediastinal, Congestion              |                      1                                                   |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1|             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pancreatic, Ectasia                  |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                            1           1           2  1     1  1  1     2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                4     4                                                   |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Cranium, Osteopetrosis               |                            3                                            2|             
      Femur, Osteopetrosis                 |                            3                                             |             
      Turbinate, Osteopetrosis             |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 3| 0| 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 2| 4| 2| 9| 9| 7| 0| 9| 9| 9| 6| 3| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   2                                               3      |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                2                                                         |             
      Granuloma, Multiple                  |                                                                          |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Histiocyte                       |                                                                          |             
      Pleura, Fibrosis, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                         2|             
      Fungus                               |                                                                         2|             
      Inflammation, Acute, Suppurative     |                                                                         2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |    1  1  1     1  1     1        1                    1        1     1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +  +  +  +  +        +|             
      Cataract                             |                                                    3  2  2  3  3        2|             
      Retina, Degeneration                 |                                                    3  3  3  3  3        3|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 | 1  2  1  1  1  1  4  1  1  2  1  1  2  2  2  1  1  2  2  1  2  3  4  2  2|             
      Cortex, Cyst                         |                                                                   2      |             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  48        |
      Parasite Metazoan                    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |     10  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Basophilic Focus, Multiple           |                                                                          |     37     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Granuloma, Multiple                  |                                                                          |     27  1.4|
      Hepatodiaphragmatic Nodule           |                                                                          |      4  2.3|
      Mixed Cell Focus                     |                                                                          |      4     |
      Necrosis, Focal                      |                                                                          |      2  1.0|
      Necrosis, Multifocal                 |                                                                          |      1  1.0|
      Regeneration                         |                                                                          |      6  1.8|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      4  2.8|
      Biliary Tract, Proliferation         |                                                                          |     18  1.3|
      Centrilobular, Necrosis              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Fat, Necrosis, Focal                 |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Acinus, Atrophy, Multifocal          |                                                                          |     22  1.5|
      Acinus, Hyperplasia, Focal           |                                                                          |      2  2.0|
      Acinus, Hyperplasia, Multifocal      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Acinus, Atrophy, Focal               |                                                                          |      4  1.3|
      Acinus, Atrophy, Multifocal          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Mineralization                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Cardiomyopathy                       |                                                                          |     33  1.3|
      Inflammation, Focal, Subacute        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  1.0|
      Degeneration, Fatty, Focal           |                                                                          |      8  2.0|
      Hyperplasia, Focal                   |                                                                          |     18  1.6|
      Hypertrophy, Focal                   |                                                                          |      4  1.3|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  49        |
      Hyperplasia, Focal                   |                                                                          |     10  1.4|
      Hyperplasia, Multifocal              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Angiectasis           |                                                                          |     35  3.0|
      Pars Distalis, Cyst                  |                                                                          |     26  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |     15  2.3|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |     24  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Ultimobranchial Cyst                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Focal           |                                                                          |      8  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  47        |
      Hyperplasia                          |                                                                          |      7  2.1|
      Inflammation, Subacute               |                                                                          |      9  2.4|
      Duct, Cyst                           |                                                                          |     14  2.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Cyst                                 |                                                                          |      5  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Dilatation                           |                                                                          |      3  2.3|
      Cervix, Abscess                      |                                                                          |      5  3.8|
      Cervix, Cyst                         |                                                                          |      5  3.8|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      1  1.0|
      Mucosa, Cyst                         |                                                                          |      3  2.0|
      Wall, Cervix, Hypertrophy            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   7        |
      Wall, Hypertrophy                    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      8  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  1.5|
      Myelofibrosis                        |                                                                          |      2  3.0|
      Pigmentation, Multifocal, Cholesterol|                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Mediastinal, Congestion              |                                                                          |      2  1.5|
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |            |
           Multifocal                      |                                                                          |     49  1.1|
      Mesenteric, Pigmentation, Multifocal,|                                                                          |            |
           Cholesterol                     |                                                                          |     49  1.0|
      Pancreatic, Ectasia                  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
      Ectasia                              |                                                                          |     21  1.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Fibrosis, Focal                      |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.7|
      Hyperplasia, Focal                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
      Cranium, Osteopetrosis               |                                                                          |      5  2.4|
      Femur, Osteopetrosis                 |                                                                          |      4  2.8|
      Turbinate, Osteopetrosis             |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Compression                          |                                                                          |      4  2.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Granuloma, Multiple                  |                                                                          |      1  1.0|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
      Pleura, Fibrosis, Focal              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Foreign Body                         |                                                                          |      2  2.0|
      Fungus                               |                                                                          |      2  2.5|
      Inflammation, Acute, Suppurative     |                                                                          |      2  2.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |                                                                          |     19  1.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  17        |
      Cataract                             |                                                                          |     17  2.8|
      Retina, Degeneration                 |                                                                          |     17  3.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |                                                                          |     49  1.8|
      Cortex, Cyst                         |                                                                          |      1  2.0|
      Papilla, Transitional Epithelium,    |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin, Multifocal          |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 9| 1| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Wall, Inflammation, Subacute         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                2     2        2        2                             2   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         2     2        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X  X                    X     X                     |             
      Basophilic Focus, Multiple           | X  X  X  X  X  X  X        X  X  X  X     X           X  X        X  X   |             
      Clear Cell Focus                     |                      X           X                                       |             
      Degeneration, Cystic, Focal          |    2                                               2                     |             
      Degeneration, Cystic, Multifocal     |                            1                    2                        |             
      Eosinophilic Focus                   |    X           X     X        X              X  X  X        X            |             
      Eosinophilic Focus, Multiple         |       X     X                                                            |             
      Granuloma, Multiple                  | 1  1  2  2  1  3  2  2  1  1  1  1  1  2  2     3  2  1  1  1     2  2  2|             
      Hepatodiaphragmatic Nodule           |                                  2  2                                    |             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           | X  X  X  X  X  X  X        X  X  X  X  X  X     X  X  X  X        X  X  X|             
      Necrosis, Multifocal                 |                                                                          |             
      Pigmentation, Multifocal, Cholesterol| 1  1  1  1  1  2  1  1     1  1  1     2  2     2  1  1  1        1  1  1|             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Biliary Tract, Dilatation, Focal     |                   1     1                                                |             
      Biliary Tract, Proliferation         |    1        1  1  1  1           1     1        1  1        2  1  1  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Inflammation, Chronic                |                                        2                                 |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                          X               |             
      Acinus, Atrophy, Multifocal          | 3  1     2  1  2     2  2  2  1  2  2  2  1        2     1     2  2  2  2|             
      Duct, Hyperplasia                    |                3                                   2                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |       1                                                                  |             
      Acinus, Atrophy, Multifocal          |                      1     1           2  1              1               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 9| 1| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  1     1  1  1        1  1  1  2  2  1  1  1  1  2     1     1  1  2|             
      Inflammation, Focal, Subacute        |                                        1                                 |             
      Atrium, Thrombosis                   |                                                                          |             
      Valve, Inflammation, Subacute        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          3               |             
      Degeneration, Fatty, Focal           |          2  3     1              4  2     2              2  2        1   |             
      Hyperplasia, Focal                   |       1  1  3  1     1           1  1  2  2           2           2     1|             
      Hyperplasia, Multifocal              |                                                                          |             
      Hypertrophy, Focal                   |             2                 1        2  2                    1         |             
      Pigmentation, Multifocal, Cholesterol|                                                                      2   |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |       1              1                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 1           1                    1        2                    1  1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          1               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    2  2  2  2  4        2  2  2     2     3           3  2  2  3        3|             
      Pars Distalis, Cyst                  |    1           2  2           2              2  2  2  1        3     2  2|             
      Pars Distalis, Hyperplasia, Focal    | 1                    2  2     1  1           2     2        3            |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |       1                    1              2              1  1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Focal, Cholesterol     |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |       2  1     2                                                  2  2   |             
      Follicle, Cyst                       |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 9| 1| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                         2                                                |             
      Inflammation, Subacute               |                                     2                                    |             
      Duct, Cyst                           |                                     2                                    |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   2        X              2     3                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                            2                    3           2           3|             
      Cervix, Abscess                      |                      4           3     4           4                     |             
      Cervix, Cyst                         |                      4           3     4           4                     |             
      Endometrium, Hyperplasia, Cystic     |                                                          2               |             
      Mucosa, Cyst                         |                                              3                 2  2      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2        2                    2  2                 4            |             
      Infiltration Cellular, Histiocyte    |          2                                1                              |             
      Myelofibrosis                        |                                                                1         |             
      Pigmentation, Multifocal, Cholesterol|          2                                1                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |             1                          3     2                           |             
      Mediastinal, Ectasia                 |             2                    1     2                                 |             
      Mesenteric, Ectasia                  |                            2                                             |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 2  1  2  2  1  2  1  3  2  2  2  2  2  4  2  1  2  1  2  2  2  2  2  2  3|             
      Mesenteric, Necrosis, Focal          |                                                                          |             
      Mesenteric, Necrosis, Multifocal     |                            2     2     2                                 |             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 2  1  2  1  2  1  1  2  2  2  2  2  2  4  2  1  2  2  2  2  2  2  2  2  2|             
      Pancreatic, Ectasia                  |                            2  2                                          |             
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      |                            2                                             |             
      Pancreatic, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  2                                       |             
      Ectasia                              |       1     1  1  1        1     2     2                       1  1     1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis, Focal                      |                                  2                                       |             
      Hematopoietic Cell Proliferation     |                                                             4            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 9| 1| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
           Subacute                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               | 3     3                       3                                3        3|             
      Femur, Osteopetrosis                 | 2  4  3        2              4  2                 3           2        2|             
      Turbinate, Osteopetrosis             | 4  2  4                       4                    3           3        4|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                2         |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hydrocephalus                        |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Histiocyte                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |          1     3                                                         |             
      Mediastinum, Inflammation, Chronic   |                                        2                                 |             
      Pleura, Congestion, Multifocal       | 2           2                       1                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                          |             
      Inflammation, Acute, Suppurative     |             1                                                            |             
      Nasolacrimal Duct, Foreign Body      |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        | 1  1  1  1  1           1     1           1     1     1  1           1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +        +  +              +               |             
      Cataract                             |                               3        3  2              2               |             
      Anterior Chamber, Hemorrhage         |                                                          2               |             
      Retina, Degeneration                 |                               4        4  3              2               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 9| 1| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Mineralization, Multifocal           |                                                                          |             
      Nephropathy, Chronic                 | 3  4  3  3  3  2  2  2  2  3  2  3  3  2  4  2  3  4  4  4  2  4  2  3  3|             
      Papilla, Necrosis                    |                                                                          |             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |    1                       1              1        1  1  1     1         |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                          3               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 8| 2| 3| 3|             
                                           | 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 3| 2| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Wall, Inflammation, Subacute         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            2                          2     2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | 2        2                       2                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                   X        X                 X  X     X     X        X   |             
      Basophilic Focus, Multiple           | X  X  X  X  X        X           X  X  X  X        X     X        X     X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic, Focal          |                            2                                             |             
      Degeneration, Cystic, Multifocal     |                                                                          |             
      Eosinophilic Focus                   |                X  X        X     X                 X        X            |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Granuloma, Multiple                  | 2  2  2  1  3     1  1  1  2     2  2  1  2     1  2  1  2  1     3  1  1|             
      Hepatodiaphragmatic Nodule           |                                        3                                 |             
      Mixed Cell Focus                     |                                     X              X  X                  |             
      Mixed Cell Focus, Multiple           | X  X  X  X  X     X  X  X  X     X     X  X     X        X        X  X  X|             
      Necrosis, Multifocal                 |                                                                   1      |             
      Pigmentation, Multifocal, Cholesterol| 1  1  2  1  2     1  1  1  1     1  1  1  1     1  1  1  1  1     1  1  1|             
      Vacuolization Cytoplasmic, Diffuse   |                   2                                                      |             
      Biliary Tract, Dilatation, Focal     | 2                                                     1                  |             
      Biliary Tract, Proliferation         | 2     1  1  1     1  1  1              1  1     1  1  1     1  1  2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                    +  +                                       |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis, Focal                 |          3                    4  3                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                             X            |             
      Acinus, Atrophy, Multifocal          | 4  3     2        3     4  2     2     3  1     3  2  2  2     3  2  1  2|             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                         1                                                |             
      Acinus, Atrophy, Multifocal          |       1                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                                      |             
      Inflammation, Subacute               |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 8| 2| 3| 3|             
                                           | 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 3| 2| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1              2           2                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  2     2     1  1     1  2  2  2  2        1     1              1|             
      Inflammation, Focal, Subacute        |                                              3                           |             
      Atrium, Thrombosis                   |                                              4                           |             
      Valve, Inflammation, Subacute        |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Degeneration, Fatty, Focal           |       1  1        1              1     3              1                  |             
      Hyperplasia, Focal                   |             2     1                 1  1  2        2  1  3               |             
      Hyperplasia, Multifocal              |                                  2                                       |             
      Hypertrophy, Focal                   | 1                                                                        |             
      Pigmentation, Multifocal, Cholesterol|                                                                          |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                        2                       2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                         2              1  2        2                    3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3  2                          4        3        2  2  4  2        3  3  3|             
      Pars Distalis, Cyst                  |       2     1     2  3        3                    2           2     3   |             
      Pars Distalis, Hyperplasia, Focal    |    2                       2           2           2     2     2         |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      | 1                                      1              1                 2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Focal, Cholesterol     |                            2                                             |             
      Ultimobranchial Cyst                 |                                                       1                  |             
      C-Cell, Hyperplasia, Focal           |    1                             1  1           2        1               |             
      Follicle, Cyst                       | 1                    3                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 8| 2| 3| 3|             
                                           | 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 3| 2| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |    2                                   3                                 |             
      Inflammation, Subacute               |    2                                                                     |             
      Duct, Cyst                           |    2                 3     3                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    4                 2                          3                    2   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2           3        3  3                                            3   |             
      Cervix, Abscess                      |                         4                          4                     |             
      Cervix, Cyst                         |                         4                          4                     |             
      Endometrium, Hyperplasia, Cystic     |                                                                2  2      |             
      Mucosa, Cyst                         |    2              2                                               2      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                   2              2              2      |             
      Infiltration Cellular, Histiocyte    |                                     2              1                     |             
      Myelofibrosis                        |                                                       2                  |             
      Pigmentation, Multifocal, Cholesterol|                                     2              1                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                              3                           |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mesenteric, Ectasia                  |                               1                 1                        |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 2  2  2  2  2     2  2  2  2  2  2  2  2  2     2  1  2  2  2  1  2  2  2|             
      Mesenteric, Necrosis, Focal          |       2                                                                  |             
      Mesenteric, Necrosis, Multifocal     |                                                             1            |             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 2  2  2  2  2     2  2  2  2  2  2  2  2  2     2  1  1  2  2  1  2  1  2|             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      |    3                                                                     |             
      Pancreatic, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              | 1  1  1           2  2  1     1  1  1              1     2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3                                                         |             
      Fibrosis, Focal                      |          2                    1                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                4                                                         |             
      Cyst                                 |    2                                                                 2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 8| 2| 3| 3|             
                                           | 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 3| 2| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
           Subacute                        |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                                     2                       3            |             
      Femur, Osteopetrosis                 |                                     3                       3            |             
      Turbinate, Osteopetrosis             |                                     4                       2            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               1                       2                  |             
      Hemorrhage, Multifocal               |                                                                4         |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Histiocyte                       |                                              2                           |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                    3                     |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
      Pleura, Congestion, Multifocal       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 2        2                 2        2                    2               |             
      Fungus                               | 3                                   3                    3     3         |             
      Inflammation, Acute, Suppurative     | 2                          2        2                    2     3         |             
      Nasolacrimal Duct, Foreign Body      |                                  2                                       |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |          3     2     1  1     1  2                    1        1  2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                 +              +  +           +  +   |             
      Cataract                             |                   3                 4              2  3           2  2   |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Retina, Degeneration                 |                   3                 4              3  4           3  3   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 8| 2| 3| 3|             
                                           | 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 3| 2| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                      4   |             
      Hydronephrosis                       |                2                                                         |             
      Metaplasia, Focal, Osseous           |                                                                   2      |             
      Mineralization, Multifocal           |                3                                                         |             
      Nephropathy, Chronic                 | 3  3  2  4  1     4  3  4  3  3  2  3  4  3     3  3  3  3  1  2  2  4  3|             
      Papilla, Necrosis                    |                3                                                         |             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |    1     1        1                    1                             2   |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                      2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                X                                                         |             
      Hemorrhage, Multifocal               |                2                                                         |             
      Mucosa, Hyperplasia                  |                4                 2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
      Wall, Inflammation, Subacute         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  48        |
      Parasite Metazoan                    |                                                                          |      8  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus                     |                                                                          |     11     |
      Basophilic Focus, Multiple           |                                                                          |     30     |
      Clear Cell Focus                     |                                                                          |      2     |
      Degeneration, Cystic, Focal          |                                                                          |      3  2.0|
      Degeneration, Cystic, Multifocal     |                                                                          |      2  1.5|
      Eosinophilic Focus                   |                                                                          |     14     |
      Eosinophilic Focus, Multiple         |                                                                          |      2     |
      Granuloma, Multiple                  |                                                                          |     44  1.6|
      Hepatodiaphragmatic Nodule           |                                                                          |      3  2.3|
      Mixed Cell Focus                     |                                                                          |      3     |
      Mixed Cell Focus, Multiple           |                                                                          |     37     |
      Necrosis, Multifocal                 |                                                                          |      1  1.0|
      Pigmentation, Multifocal, Cholesterol|                                                                          |     41  1.1|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  2.0|
      Biliary Tract, Dilatation, Focal     |                                                                          |      4  1.3|
      Biliary Tract, Proliferation         |                                                                          |     29  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  49        |
      Basophilic Focus                     |                                                                          |      2     |
      Acinus, Atrophy, Multifocal          |                                                                          |     36  2.1|
      Duct, Hyperplasia                    |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Acinus, Atrophy, Focal               |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinus, Atrophy, Multifocal          |                                                                          |      6  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Mineralization                       |                                                                          |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Cardiomyopathy                       |                                                                          |     34  1.4|
      Inflammation, Focal, Subacute        |                                                                          |      2  2.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
      Valve, Inflammation, Subacute        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Degeneration, Fatty, Focal           |                                                                          |     15  1.8|
      Hyperplasia, Focal                   |                                                                          |     20  1.6|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      6  1.5|
      Pigmentation, Multifocal, Cholesterol|                                                                          |      1  2.0|
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia, Focal                   |                                                                          |     11  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Angiectasis           |                                                                          |     26  2.6|
      Pars Distalis, Cyst                  |                                                                          |     19  2.1|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |     14  1.9|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      9  1.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Focal, Cholesterol     |                                                                          |      1  2.0|
      Ultimobranchial Cyst                 |                                                                          |      1  1.0|
      C-Cell, Hyperplasia, Focal           |                                                                          |     10  1.5|
      Follicle, Cyst                       |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      3  2.3|
      Inflammation, Subacute               |                                                                          |      2  2.0|
      Duct, Cyst                           |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Cyst                                 |                                                                          |      8  2.6|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Dilatation                           |                                                                          |      9  2.7|
      Cervix, Abscess                      |                                                                          |      6  3.8|
      Cervix, Cyst                         |                                                                          |      6  3.8|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      3  2.0|
      Mucosa, Cyst                         |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      9  2.2|
      Infiltration Cellular, Histiocyte    |                                                                          |      4  1.5|
      Myelofibrosis                        |                                                                          |      2  1.5|
      Pigmentation, Multifocal, Cholesterol|                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Mediastinal, Congestion              |                                                                          |      4  2.3|
      Mediastinal, Ectasia                 |                                                                          |      3  1.7|
      Mesenteric, Ectasia                  |                                                                          |      3  1.3|
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |            |
           Multifocal                      |                                                                          |     48  1.9|
      Mesenteric, Necrosis, Focal          |                                                                          |      1  2.0|
      Mesenteric, Necrosis, Multifocal     |                                                                          |      4  1.8|
      Mesenteric, Pigmentation, Multifocal,|                                                                          |            |
           Cholesterol                     |                                                                          |     48  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Ectasia                  |                                                                          |      2  2.0|
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |            |
           Multifocal                      |                                                                          |      2  2.5|
      Pancreatic, Pigmentation, Multifocal,|                                                                          |            |
           Cholesterol                     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  49        |
      Congestion                           |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |     21  1.2|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Fibrosis, Focal                      |                                                                          |      3  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      3  1.7|
      Artery, Mediastinum, Inflammation,   |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Cranium, Osteopetrosis               |                                                                          |      7  2.9|
      Femur, Osteopetrosis                 |                                                                          |     11  2.7|
      Turbinate, Osteopetrosis             |                                                                          |      9  3.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Compression                          |                                                                          |      3  1.7|
      Hemorrhage, Multifocal               |                                                                          |      1  4.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      3  2.3|
      Mediastinum, Inflammation, Chronic   |                                                                          |      1  2.0|
      Pleura, Congestion, Multifocal       |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Foreign Body                         |                                                                          |      5  2.0|
      Fungus                               |                                                                          |      4  3.0|
      Inflammation, Acute, Suppurative     |                                                                          |      6  2.0|
      Nasolacrimal Duct, Foreign Body      |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |                                                                          |     21  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  10        |
      Cataract                             |                                                                          |     10  2.6|
      Anterior Chamber, Hemorrhage         |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |     10  3.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  49        |
      Fibrosis, Focal                      |                                                                          |      1  4.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Metaplasia, Focal, Osseous           |                                                                          |      1  2.0|
      Mineralization, Multifocal           |                                                                          |      1  3.0|
      Nephropathy, Chronic                 |                                                                          |     48  2.9|
      Papilla, Necrosis                    |                                                                          |      1  3.0|
      Papilla, Transitional Epithelium,    |                                                                          |            |
           Hyperplasia                     |                                                                          |     12  1.1|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.25%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +                       +  +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +                       +  +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +                       +  +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +                       +  +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +                       +  +                             +            |             
      Parasite Metazoan                    | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +                       +  +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +                       +  +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +                       +  +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +                       +  +                             +            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |       2                          3                                       |             
      Basophilic Focus                     |    X  X        X     X           X  X  X  X     X                 X  X  X|             
      Basophilic Focus, Multiple           | X        X  X     X     X  X  X              X     X  X  X     X         |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Degeneration, Cystic, Multifocal     |       2                                                                  |             
      Eosinophilic Focus                   |       X           X  X     X     X  X  X                                X|             
      Eosinophilic Focus, Multiple         |                               X                                          |             
      Granuloma, Multiple                  |       1  2  2  1  1  2  1  2  1  1  3  2  1  1  1  2  3  1     3     2  2|             
      Hepatodiaphragmatic Nodule           | 3                                                     X        3     3  2|             
      Mixed Cell Focus                     |             X  X              X        X     X                           |             
      Mixed Cell Focus, Multiple           |                      X     X              X        X  X        X     X  X|             
      Pigmentation, Multifocal, Cholesterol|             2              2           1           1  1        1     1  1|             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Biliary Tract, Dilatation, Focal     | 2                                                                        |             
      Biliary Tract, Proliferation         |                         1  1  2              2     2  2              2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                    +                       +                 +  +  +|             
      Fat, Necrosis, Focal                 |    3                    3                       4                 4  3  4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X                                                               |             
      Acinus, Atrophy, Multifocal          |    2     1  1  2  2  2  2     1  2     1     1  4  1  2     2  3     1  3|             
      Artery, Hypertrophy                  |                   2                                                      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +                       +  +                             +            |             
      Acinus, Atrophy, Multifocal          | 1                                                                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +                       +  +                             +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +                       +  +                             +            |             
      Hyperplasia                          |                                                             2            |             
      Inflammation, Subacute               |                                                             2            |             
      Perforation                          |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +                       +  +                             +            |             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.25%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +                       +  +                             +            |             
      Cardiomyopathy                       |                            2  2                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +                    +  +                             +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +                    +  +                             +            |             
      Angiectasis                          |                            3                                             |             
      Degeneration, Fatty, Focal           | 2                          4                                             |             
      Degeneration, Fatty, Multifocal      |                                                                          |             
      Hyperplasia, Focal                   | 2                             2                                          |             
      Hypertrophy, Focal                   |                               2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +                    +  +                             +            |             
      Hyperplasia, Focal                   | 1                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +                       +  +                             +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +           +     +     +  +                          +  +        +  +|             
      Cyst                                 |    1                                                                     |             
      Pars Distalis, Angiectasis           | 2              3     3     3                                         2  2|             
      Pars Distalis, Cyst                  |                               2                                         2|             
      Pars Distalis, Hyperplasia, Focal    |    1                                                                     |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                            2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +                       +  +                             +  +         |             
      Ultimobranchial Cyst                 |                            2                                             |             
      C-Cell, Hyperplasia, Focal           |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +                       +  +                             +        +   |             
      Hyperplasia                          |                                                                          |             
      Duct, Cyst                           |                                                                      2   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +                       +  +     +                       +            |             
      Cyst                                 |                                     4                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +           +        +  +  +        +  +  +  +           +  +         |             
      Dilatation                           |                                                                          |             
      Cervix, Abscess                      |                3        4                       4              4         |             
      Cervix, Cyst                         |                4        4              4        4              4         |             
      Mucosa, Cyst                         |                                              2                           |             
                                            __________________________________________________________________________|             
   Vagina                                  |                               +                 +           +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.25%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +                       +  +                             +            |             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                         2           2  1        1                 2      |             
      Mediastinal, Ectasia                 |                                     2  1                                 |             
      Mesenteric, Ectasia                  |                                     2                                    |             
      Mesenteric, Fibrosis, Focal          |                         2                                                |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 1     2  2  2  2  1  1  2  2  2  2  2  2  1  2  1  3  2  2     2  2  1  2|             
      Mesenteric, Necrosis, Focal          |                         2                             2           2      |             
      Mesenteric, Necrosis, Multifocal     |                                                                          |             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 1     2  2  2  2  2  1  2  1  1  2  2  2  1  1  1  2  1  2     2  2  1  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |             1     2  1  1  1        2        1  1     1              1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                                                                     |             
      Hematopoietic Cell Proliferation     |                                     3                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +                       +  +                             +            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +        +        +  +  +  +  +  +     +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +                       +  +     +                    +  +            |             
      Cranium, Osteopetrosis               |                                                                          |             
      Femur, Osteopetrosis                 |                                     3                                    |             
      Turbinate, Osteopetrosis             |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +                       +  +                          +  +            |             
      Compression                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage, Multifocal               |                                           2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +                       +  +                             +            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                                                             2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +                       +  +                             +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.25%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +  +  +  +  +     +     +  +               |             
      Cataract                             |                               3  2  2  4  2     2     2  2               |             
      Retina, Degeneration                 |                               3  3  3  4  3     4     4  3               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                2                                                         |             
      Nephropathy, Chronic                 | 1  2  2  2  2  2  2  3  2  3  2  3  2  2  3  3  2  3  2  3  2  2  3  3  3|             
      Artery, Inflammation, Subacute       |                   2                                                      |             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |                            2                                      1      |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                            2                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +                       +  +                             +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8| 3| 3| 3| 5| 9| 0| 3| 3| 9| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 0| 1| 1| 1| 3| 4| 8| 1| 1| 7| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +              +  +           +  +  +        +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +              +  +           +  +  +        +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +              +  +           +  +  +        +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +              +  +           +  +  +        +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +              +  +           +  +  +        +            |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +              +  +           +  +  +        +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                M              +  +           +  +  +        +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +              +  +           +  +  A        +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +              +  A           A  +  A        +            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Basophilic Focus                     |    X  2           X                                                  X  X|             
      Basophilic Focus, Multiple           | X        X  X        X  X  X        X  X     X  X     X  X     X  X      |             
      Degeneration, Cystic, Focal          |                         2                                               2|             
      Degeneration, Cystic, Multifocal     |                                                                          |             
      Eosinophilic Focus                   |    X              X                          X                 X        X|             
      Eosinophilic Focus, Multiple         | X        X                                      X           X            |             
      Granuloma, Multiple                  | 1  2  2  2     1  1  2     1  1  1  1  1  1  1  1     2  1  1  1  2  1  1|             
      Hepatodiaphragmatic Nodule           |          3  X           3  3                          2        3        3|             
      Mixed Cell Focus                     |    X           X     X  X        X        X                       X  X   |             
      Mixed Cell Focus, Multiple           |       X  X  X              X        X        X        X  X     X         |             
      Pigmentation, Multifocal, Cholesterol|    1  1  2           1                                1           1      |             
      Vacuolization Cytoplasmic, Multifocal|                1                                                         |             
      Biliary Tract, Dilatation, Focal     |          2                                                               |             
      Biliary Tract, Proliferation         | 2     2  2  2     2  2  2                 1                    2  2     2|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +                       +                       +      |             
      Fat, Necrosis, Focal                 |             3     3                       4                       3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                           X                              |             
      Acinus, Atrophy, Multifocal          |    4  1     1  1  1  3  2  3  2  2  2  1     2  2  2  2  3  4  3  1  3  1|             
      Artery, Hypertrophy                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                    +                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +              +  +           +  +  +        +            |             
      Acinus, Atrophy, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +              +  +           +  +  +        +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +              +  +           +  +  +        +            |             
      Hyperplasia                          |                2                                                         |             
      Inflammation, Subacute               |                4                                                         |             
      Perforation                          |                4                                                         |             
      Ulcer                                |                4                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +              +  +           +  +  +        +            |             
      Erosion                              |                                                             3            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +                    +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8| 3| 3| 3| 5| 9| 0| 3| 3| 9| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 0| 1| 1| 1| 3| 4| 8| 1| 1| 7| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +              +  +           +  +  +        +            |             
      Cardiomyopathy                       |                               1  2              2  2        2            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +              +  +           +  +  +        +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +              +  +           +  +  +        +            |             
      Angiectasis                          |                                                                          |             
      Degeneration, Fatty, Focal           |                2              2  2                          2            |             
      Degeneration, Fatty, Multifocal      |                                                 2                        |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +              +  +           +  +  +        +            |             
      Hyperplasia, Focal                   |                                                 2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +              +  +           +  +  +        +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +           +  +           +  +  +     +  +     +      |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           |                3  3                          3     2     3        2      |             
      Pars Distalis, Cyst                  |                                                 2  2     2  2            |             
      Pars Distalis, Hyperplasia, Focal    |                                                 2           2            |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                   2                                2     2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +              +  +           +  +  +        +            |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                +           +  +  +           +  +  +        +            |             
      Hyperplasia                          |                            4                                             |             
      Duct, Cyst                           |                            3                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +              +  +           +  +  +  +     +            |             
      Cyst                                 |                               1              2  1     4                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +     +  +     +  +  +  +  +     +  +  +  +  +     +           +|             
      Dilatation                           |                                  1        2                              |             
      Cervix, Abscess                      | 2        3              3  4        3           3     3                 4|             
      Cervix, Cyst                         | 4        3              4  4        3           3     3                 4|             
      Mucosa, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                         +        +                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8| 3| 3| 3| 5| 9| 0| 3| 3| 9| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 0| 1| 1| 1| 3| 4| 8| 1| 1| 7| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +              +  +           +  +  +        +            |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              | 2                                2                                       |             
      Mediastinal, Ectasia                 |                         2                                            1   |             
      Mesenteric, Ectasia                  |          1                                                               |             
      Mesenteric, Fibrosis, Focal          |                                                                          |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 2  1  2  1  1  2  1  2  1  2  1  1  1  1  1  2  2  2  2  2  2  1  1  2  1|             
      Mesenteric, Necrosis, Focal          |                                                                          |             
      Mesenteric, Necrosis, Multifocal     |                                              2                           |             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 1  1  2  1  1  1  1  1  1  2     1  1  1  1  1  2  2  1  2  1  1  1  2  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    2                     |             
      Ectasia                              |                1  1     1           1     1                 1     1  1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +              +  +           +  +  +        +            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +     +     +        +  +  +  +     +  +  +     +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +        +  +  +           +  +  +        +            |             
      Cranium, Osteopetrosis               |                   2        1                 2                           |             
      Femur, Osteopetrosis                 |                   2                          2                           |             
      Turbinate, Osteopetrosis             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +              +  +           +  +  +        +            |             
      Compression                          |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                           |             
      Hemorrhage, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +              +  +           +  +  +        +            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +              +  +           +  +  +        +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8| 3| 3| 3| 5| 9| 0| 3| 3| 9| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 0| 1| 1| 1| 3| 4| 8| 1| 1| 7| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +        +     +  +     +         |             
      Cataract                             |                                        4        3     4  3     4         |             
      Retina, Degeneration                 |                                        4        3     4  3     4         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Nephropathy, Chronic                 | 3  3  2  2  1  3  3  3  3  3  1  2  2  3  2  2  2  2  2  3  2  2  2  3  3|             
      Artery, Inflammation, Subacute       |                                                                          |             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |                      1                                                  1|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +              +  +           +  +  +        +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 9| 9| 9| 8| 8| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    1.25%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  12        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Angiectasis, Multifocal              |                                                                          |      2  2.5|
      Basophilic Focus                     |                                                                          |     17  2.0|
      Basophilic Focus, Multiple           |                                                                          |     26     |
      Degeneration, Cystic, Focal          |                                                                          |      2  2.0|
      Degeneration, Cystic, Multifocal     |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |     13     |
      Eosinophilic Focus, Multiple         |                                                                          |      5     |
      Granuloma, Multiple                  |                                                                          |     43  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |     12  2.8|
      Mixed Cell Focus                     |                                                                          |     13     |
      Mixed Cell Focus, Multiple           |                                                                          |     17     |
      Pigmentation, Multifocal, Cholesterol|                                                                          |     14  1.2|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      1  1.0|
      Biliary Tract, Dilatation, Focal     |                                                                          |      2  2.0|
      Biliary Tract, Proliferation         |                                                                          |     18  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  10        |
      Fat, Necrosis, Focal                 |                                                                          |     10  3.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Basophilic Focus                     |                                                                          |      2     |
      Acinus, Atrophy, Multifocal          |                                                                          |     40  2.0|
      Artery, Hypertrophy                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  12        |
      Acinus, Atrophy, Multifocal          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  12        |
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Subacute               |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 9| 9| 9| 8| 8| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    1.25%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Perforation                          |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  12        |
      Erosion                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  12        |
      Cardiomyopathy                       |                                                                          |      7  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  13        |
      Angiectasis                          |                                                                          |      1  3.0|
      Degeneration, Fatty, Focal           |                                                                          |      6  2.3|
      Degeneration, Fatty, Multifocal      |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  13        |
      Hyperplasia, Focal                   |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  20        |
      Cyst                                 |                                                                          |      1  1.0|
      Pars Distalis, Angiectasis           |                                                                          |     12  2.6|
      Pars Distalis, Cyst                  |                                                                          |      6  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      3  1.7|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  13        |
      Ultimobranchial Cyst                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Focal           |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  14        |
      Hyperplasia                          |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 9| 9| 9| 8| 8| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    1.25%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Duct, Cyst                           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  14        |
      Cyst                                 |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  28        |
      Dilatation                           |                                                                          |      2  1.5|
      Cervix, Abscess                      |                                                                          |     12  3.3|
      Cervix, Cyst                         |                                                                          |     13  3.7|
      Mucosa, Cyst                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  12        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Mediastinal, Congestion              |                                                                          |      7  1.7|
      Mediastinal, Ectasia                 |                                                                          |      4  1.5|
      Mesenteric, Ectasia                  |                                                                          |      2  1.5|
      Mesenteric, Fibrosis, Focal          |                                                                          |      1  2.0|
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |            |
           Multifocal                      |                                                                          |     48  1.6|
      Mesenteric, Necrosis, Focal          |                                                                          |      3  2.0|
      Mesenteric, Necrosis, Multifocal     |                                                                          |      1  2.0|
      Mesenteric, Pigmentation, Multifocal,|                                                                          |            |
           Cholesterol                     |                                                                          |     47  1.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |     18  1.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  33        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  16        |
      Cranium, Osteopetrosis               |                                                                          |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 9| 9| 9| 8| 8| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    1.25%                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Femur, Osteopetrosis                 |                                                                          |      3  2.3|
      Turbinate, Osteopetrosis             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  13        |
      Compression                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  12        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  13        |
      Cataract                             |                                                                          |     13  2.8|
      Retina, Degeneration                 |                                                                          |     13  3.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |                                                                          |     50  2.4|
      Artery, Inflammation, Subacute       |                                                                          |      1  2.0|
      Papilla, Transitional Epithelium,    |                                                                          |            |
           Hyperplasia                     |                                                                          |      4  1.3|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +              +              +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +              +              +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +              +              +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +              +              +                             +            |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +              +              +                             +            |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +              +              +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +              +              +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +              +              +                             +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +              +              +                             +            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X           X           X     X  X              X  X|             
      Basophilic Focus, Multiple           | X  X  X  X  X  X        X  X           X  X     X        X     X         |             
      Degeneration, Cystic, Focal          |                            1                                             |             
      Eosinophilic Focus                   |             X                                                            |             
      Granuloma, Multiple                  |          1     2  1     2  1     1  1        1  1                        |             
      Hepatodiaphragmatic Nodule           |                   2                 3     2                              |             
      Mixed Cell Focus                     |       X        X  X     X                                                |             
      Mixed Cell Focus, Multiple           | X                                                     X                 X|             
      Pigmentation, Multifocal, Cholesterol|                   1                                                      |             
      Vacuolization Cytoplasmic, Diffuse   |                               4                                          |             
      Biliary Tract, Proliferation         |       2     2           2  2        2                 2  2               |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +              +                                                |             
      Inflammation, Granulomatous          |       2                                                                  |             
      Fat, Necrosis, Focal                 |       3  3              3                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                       X                  |             
      Acinus, Atrophy, Multifocal          | 3     3  1  1  2  3  2  2  3     2  1  2  1     3     2  1  2           2|             
      Artery, Inflammation, Subacute       |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                 +                        |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +              +              +                             +            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +              +              +                             +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +              +              +                             +            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +              +              +                             +            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +              +              +                             +            |             
      Cardiomyopathy                       | 1              1                                                         |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +              +              +        +                    +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +              +              +        +                    +     +     +|             
      Angiectasis                          |                                                                         3|             
      Degeneration, Fatty, Focal           |                                                                          |             
      Degeneration, Fatty, Multifocal      |                2                                                        3|             
      Hyperplasia, Focal                   |                2                                                         |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +              +              +        +                    +     +     +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +              +              +                             M            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +  +           +  +        +                    +  +         |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           |             2  2           2           2                       2         |             
      Pars Distalis, Cyst                  | 2           2              2                                   2         |             
      Pars Distalis, Hemorrhage            |             2                                                            |             
      Pars Distalis, Hyperplasia, Focal    | 2                                                           2            |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +              +        +     +                             +     +      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +              +     +        +                       +     +        +   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Subacute               |                      2                                2                  |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +              +              +                             +            |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +  +     +        +  +     +  +                 +        +   |             
      Dilatation                           |                      2                                                   |             
      Hemorrhage                           |                                                                          |             
      Cervix, Abscess                      |                                        3  3                              |             
      Cervix, Abscess, Multiple            |                                                                          |             
      Cervix, Cyst                         |                                        3  3                              |             
      Cervix, Cyst, Multiple               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +              +              +                             +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                         1     3                                          |             
      Mediastinal, Ectasia                 |                   1     1                                                |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 2  2  2  1  1  1  2  1  2  1  1  1  1  1  2  1  1  1  1  1  2  2     1  1|             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 1  1  1  1  1  1  2  1  2  1     1  1  1  1  1  1  1  1  1  1  1     1  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  2                                       |             
      Ectasia                              |    1     1  1  1     1                 2                 1     1  1  1  1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                2                                                         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +              +              +                             +            |             
      Cyst                                 |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +     +     +  +  +  +     +  +        +  +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +              +              +  +                          +     +     +|             
      Inflammation, Chronic                |                                                                          |             
      Femur, Osteopetrosis                 |                                  2                                      2|             
      Turbinate, Osteopetrosis             |                                  3                                       |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +              +              +                             +            |             
      Compression                          |                2                                                         |             
      Hemorrhage, Multifocal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin, Multifocal|                         1                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +              +              +                             +            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +              +              +                             +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +     +  +                              |             
      Cataract                             |                                  4     2  2                              |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.6%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Posterior Chamber, Hemorrhage        |                                                                          |             
      Retina, Degeneration                 |                                  4     3  3                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Nephropathy, Chronic                 | 2  3  2  3  2  2  2  2  3  3  2  2  2  2  2  3  2  1  2  3  2  2  3  2  3|             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |                                              1           1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +              +              +                             +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 5| 0| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 7| 8| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +                          M  +           +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +                          +  +           +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                A  +                          +  +           +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +                          +  +           +  +         |             
      Parasite Metazoan                    |                                              2              2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +                          +  +           +  +         |             
      Parasite Metazoan                    |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +  +                          +  +           +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +                          +  +           +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +                          +  +           +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                A  +                          +  +           +  +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2        X                          X  X                                 |             
      Basophilic Focus, Multiple           |    X  X     X     X  X  X  X  X  X        X        X     X  X     X  X  X|             
      Degeneration, Cystic, Focal          |                                                                          |             
      Eosinophilic Focus                   |       X  X           X           X  X                    X               |             
      Granuloma, Multiple                  |    2  2     1     1  1     1     1  1  1  1     1  1                     |             
      Hepatodiaphragmatic Nodule           |    3  3                                2                                 |             
      Mixed Cell Focus                     |    X        X        X     X     X  X                                    |             
      Mixed Cell Focus, Multiple           |       X                                X  X                              |             
      Pigmentation, Multifocal, Cholesterol|    1  1                                                                  |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Biliary Tract, Proliferation         |    2           2     2              2                 2                  |             
      Centrilobular, Necrosis              |                                                                2         |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                   +                                   +|             
      Inflammation, Granulomatous          |                                                                          |             
      Fat, Necrosis, Focal                 | 3                                   3                                   3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Acinus, Atrophy, Multifocal          | 2  3           2  3  2  2  2  1  2  1              2  2        1  2  1   |             
      Artery, Inflammation, Subacute       |                                                                         2|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                +                                                         |             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +                          +  +           +  +         |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +                          +  +           +  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +                          +              +  +         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +                          +              +  +         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
      Dysplasia                            |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +                          +  +           +  +         |             
      Cardiomyopathy                       |                1  1                             1           1            |             
      Atrium, Thrombosis                   |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 5| 0| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 7| 8| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +  +  +                          +  +           +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +  +  +                          +  +           +  +  +     +|             
      Angiectasis                          |                                                                          |             
      Degeneration, Fatty, Focal           |                                                             2            |             
      Degeneration, Fatty, Multifocal      |                                                                   3      |             
      Hyperplasia, Focal                   |                   2                             2                        |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +  +  +                          +  +           +  +  +     +|             
      Hyperplasia, Focal                   |                   2                                            1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +                          +  +           +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +     +  +  +           +        +  +  +  +           +  +  +     +|             
      Cyst                                 |       2                                                                  |             
      Pars Distalis, Angiectasis           | 2     2     2  2  2           2        2        2                 3     3|             
      Pars Distalis, Cyst                  |             2                 2        2  2                 2  2         |             
      Pars Distalis, Hemorrhage            |                                                 3                        |             
      Pars Distalis, Hyperplasia, Focal    |             2                             3                 2            |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |       2     2                                                           1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +                          +  +           +  +         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                +  +                       +  M  +           +  +        +|             
      Hyperplasia                          |                                           3                             2|             
      Inflammation, Subacute               |                                           3                              |             
      Duct, Cyst                           |                                                                         2|             
                                            __________________________________________________________________________|             
   Ovary                                   |          +     +  +     +              +     +  +           +  +     +   |             
      Cyst                                 |                2                       3                             3   |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +        +  +  +  +              +     +  +        +  +  +        +|             
      Dilatation                           |                                                             3            |             
      Hemorrhage                           |                                        2                                 |             
      Cervix, Abscess                      |                   4                                      4              4|             
      Cervix, Abscess, Multiple            |                         4                                                |             
      Cervix, Cyst                         |                   4                                      4              4|             
      Cervix, Cyst, Multiple               |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +                          +  +           +  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 5| 0| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 7| 8| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Ectasia                 |       1                                                                  |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 1  2  2  1  2  2  2  2  1  1  1  2  2  1  1     2  1  2  2  1  1  1  1  1|             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 1  2  2     1     2  2  1  1  1  2  2  2  1     1  1  1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                      1        1                    1  1     1           1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                              4                           |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +                          +  +           +  +        +|             
      Cyst                                 |                                                                         3|             
      Inflammation, Subacute               |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |          +     +  +     +                 +  +  +     +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +                          +  +     +     +  +  +      |             
      Inflammation, Chronic                |                                                                   4      |             
      Femur, Osteopetrosis                 |                                                       2                  |             
      Turbinate, Osteopetrosis             |                                                       3                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +                          +  +           +  +         |             
      Compression                          |                                                                          |             
      Hemorrhage, Multifocal               |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +                          +  +           +  +         |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +                          +  +           +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +        +                 +  +  +  +        +  +  +|             
      Cataract                             |                      2        2                 3  3  2  4        2  2  2|             
      Anterior Chamber, Hemorrhage         |                                                 2     2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 5| 0| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 7| 8| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.6%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Posterior Chamber, Hemorrhage        |                                                       2                  |             
      Retina, Degeneration                 |                               3                 3  3  2  4        3  3  4|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
      Hyperplasia                          |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                  2                                       |             
      Nephropathy, Chronic                 | 3  2  2  2  2  2  2  2  3  3  2  2  2  3  2     2  2  3  2  1  3  2  2  3|             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |                                                       1        2        1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +                          +  +           +  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 9| 9| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  10        |
      Parasite Metazoan                    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  10        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus                     |                                                                          |     11  2.0|
      Basophilic Focus, Multiple           |                                                                          |     29     |
      Degeneration, Cystic, Focal          |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      7     |
      Granuloma, Multiple                  |                                                                          |     21  1.2|
      Hepatodiaphragmatic Nodule           |                                                                          |      6  2.5|
      Mixed Cell Focus                     |                                                                          |     10     |
      Mixed Cell Focus, Multiple           |                                                                          |      6     |
      Pigmentation, Multifocal, Cholesterol|                                                                          |      3  1.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  4.0|
      Biliary Tract, Proliferation         |                                                                          |     12  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                                                                          |      6  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Acinus, Atrophy, Multifocal          |                                                                          |     33  1.9|
      Artery, Inflammation, Subacute       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   2        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Dysplasia                            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 9| 9| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  10        |
      Cardiomyopathy                       |                                                                          |      6  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  16        |
      Angiectasis                          |                                                                          |      1  3.0|
      Degeneration, Fatty, Focal           |                                                                          |      1  2.0|
      Degeneration, Fatty, Multifocal      |                                                                          |      3  2.7|
      Hyperplasia, Focal                   |                                                                          |      3  2.0|
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  16        |
      Hyperplasia, Focal                   |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  22        |
      Cyst                                 |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |                                                                          |     15  2.1|
      Pars Distalis, Cyst                  |                                                                          |     10  2.0|
      Pars Distalis, Hemorrhage            |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      5  2.2|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  14        |
      Hyperplasia                          |                                                                          |      2  2.5|
      Inflammation, Subacute               |                                                                          |      3  2.3|
      Duct, Cyst                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  14        |
      Cyst                                 |                                                                          |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 9| 9| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  23        |
      Dilatation                           |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Cervix, Abscess                      |                                                                          |      5  3.6|
      Cervix, Abscess, Multiple            |                                                                          |      1  4.0|
      Cervix, Cyst                         |                                                                          |      5  3.6|
      Cervix, Cyst, Multiple               |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  10        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Mediastinal, Congestion              |                                                                          |      2  2.0|
      Mediastinal, Ectasia                 |                                                                          |      3  1.0|
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |            |
           Multifocal                      |                                                                          |     48  1.4|
      Mesenteric, Pigmentation, Multifocal,|                                                                          |            |
           Cholesterol                     |                                                                          |     45  1.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |     17  1.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  11        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  26        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  15        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Femur, Osteopetrosis                 |                                                                          |      3  2.0|
      Turbinate, Osteopetrosis             |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 9| 9| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.6%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  10        |
      Compression                          |                                                                          |      1  2.0|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Pigmentation, Hemosiderin, Multifocal|                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  12        |
      Cataract                             |                                                                          |     12  2.5|
      Anterior Chamber, Hemorrhage         |                                                                          |      2  2.0|
      Posterior Chamber, Hemorrhage        |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |     11  3.2|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |                                                                          |     49  2.3|
      Papilla, Transitional Epithelium,    |                                                                          |            |
           Hyperplasia                     |                                                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 0| 2| 2| 2| 1| 6| 0| 2| 2| 5| 5| 2| 2| 2| 3| 6| 2| 2| 2| 5| 1| 4| 6| 2|             
                                           | 6| 0| 9| 9| 9| 0| 6| 6| 9| 9| 3| 8| 9| 9| 9| 4| 6| 9| 9| 9| 3| 1| 4| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            2     2                    2  2               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |             1                                                            |             
      Angiectasis, Multifocal              |                                                                          |             
      Basophilic Focus                     |                         X  X              X  X           X  X           X|             
      Basophilic Focus, Multiple           |             X                                                            |             
      Clear Cell Focus                     |                                                                         X|             
      Degeneration, Cystic, Focal          |                                                    1     2           1  2|             
      Degeneration, Cystic, Multifocal     |                                                                          |             
      Eosinophilic Focus                   |                                                          X              X|             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Fibrosis                             |                                                                          |             
      Granuloma, Multiple                  |       1  1  1     1     1  1     1  1  1  1  1        1                  |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Hepatodiaphragmatic Nodule           |                                           2                              |             
      Mixed Cell Focus                     |                         X                                                |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pigmentation, Multifocal, Cholesterol|                                                                          |             
      Regeneration                         |    2           2     3        2                 2              2  1      |             
      Thrombosis                           |                                                                   3      |             
      Biliary Tract, Proliferation         | 1  3  1  1  1  3  2  3  2  3  3  2  2  3  2  2  4  2  2  3  1  2  3     2|             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                   +              +        +     +     +|             
      Fat, Inflammation, Chronic,          |                                                                          |             
          Multifocal                       |                                                                   2      |             
      Fat, Necrosis, Focal                 |                                     4                                   4|             
      Fat, Necrosis, Multifocal            |                                                    3              3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Acinus, Atrophy, Multifocal          |             1  3     1  1  2        1     2     2     2     1     3      |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Acinus, Hyperplasia, Multifocal      |                                                                          |             
      Artery, Inflammation, Subacute       |                                                                          |             
      Duct, Cyst                           |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 0| 2| 2| 2| 1| 6| 0| 2| 2| 5| 5| 2| 2| 2| 3| 6| 2| 2| 2| 5| 1| 4| 6| 2|             
                                           | 6| 0| 9| 9| 9| 0| 6| 6| 9| 9| 3| 8| 9| 9| 9| 4| 6| 9| 9| 9| 3| 1| 4| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer, Multiple                      |                                                                      2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   2                                                      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Foreign Body, Multiple               |                                                                          |             
      Granuloma, Multiple                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +   |             
      Aorta, Mineralization                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     2  2  2  1     1  1  1        2  2  2  2     2     2  1  1  2  1  1|             
      Fibrosis, Focal                      |       2                                                                  |             
      Inflammation, Multifocal, Subacute   |                                                                      2   |             
      Mineralization, Multifocal           |                                                                      1   |             
      Atrium, Thrombosis                   |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           | 1     1                          1     3  1                          2   |             
      Degeneration, Fatty, Multifocal      |    2                                                                     |             
      Hyperplasia, Focal                   |       1                             1                       1            |             
      Hyperplasia, Multifocal              |                                           1                             2|             
      Necrosis, Multifocal                 |                                                                   3      |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                                                          |             
      Capsule, Hemorrhage                  |                      4                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2     2  2           2        1  1  1     2  2  1              1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       3                 4  3  3                 2     3                  |             
      Pars Distalis, Cyst                  |                                                 2                        |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |       2                                                           2     2|             
      Pars Distalis, Pigmentation,         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 0| 2| 2| 2| 1| 6| 0| 2| 2| 5| 5| 2| 2| 2| 3| 6| 2| 2| 2| 5| 1| 4| 6| 2|             
                                           | 6| 0| 9| 9| 9| 0| 6| 6| 9| 9| 3| 8| 9| 9| 9| 4| 6| 9| 9| 9| 3| 1| 4| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
          Hemosiderin                      |                               2                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           | 1                                                     2                  |             
      Follicle, Cyst                       | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                      +   |             
      Dilatation                           |                                                                      2   |             
      Inflammation                         |                                                                      2   |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                   4      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |       4                 3                             2                  |             
      Inflammation, Subacute               |       2                          4                    2                  |             
      Duct, Cyst                           |       X                 3  3     3                    2                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |    1  1     1  2  1  1     1           2  1  1  1  1  2     2     2  3  1|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                      3   |             
      Inflammation, Subacute               |                                                                      2   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2           2                 2                    2        2   |             
      Mineralization                       |                                                                          |             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Multifocal                       |                                                 1                    1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                             3                 3           3  4        2|             
      Myelofibrosis                        |                3     2                                            2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Congestion              |                   2                                                      |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                             4            |             
      Mesenteric, Congestion               |                                                                          |             
      Mesenteric, Ectasia                  |                                  2                                       |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 2  1  1  2  3  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 0| 2| 2| 2| 1| 6| 0| 2| 2| 5| 5| 2| 2| 2| 3| 6| 2| 2| 2| 5| 1| 4| 6| 2|             
                                           | 6| 0| 9| 9| 9| 0| 6| 6| 9| 9| 3| 8| 9| 9| 9| 4| 6| 9| 9| 9| 3| 1| 4| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      |                                                                          |             
      Pancreatic, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |       1  1              1        1                       1     2  2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |             1           2                       2     2                  |             
      Fibrosis, Multifocal                 | 2                                                                        |             
      Hematopoietic Cell Proliferation     |                                                             4            |             
      Infiltration Cellular, Lipocyte      |                         1                                                |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +|             
      Cyst                                 | 2                                      2                             2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       2                  |             
      Duct, Cyst                           |                      3        3  2              2     2           2  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                            3                                             |             
      Subcutaneous Tissue, Abscess, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                       3                  |             
      Hemorrhage, Multifocal               |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              1                           |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 0| 2| 2| 2| 1| 6| 0| 2| 2| 5| 5| 2| 2| 2| 3| 6| 2| 2| 2| 5| 1| 4| 6| 2|             
                                           | 6| 0| 9| 9| 9| 0| 6| 6| 9| 9| 3| 8| 9| 9| 9| 4| 6| 9| 9| 9| 3| 1| 4| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         | 2     2                 2                                      2         |             
      Fungus                               | 3     3  3              3                                      3         |             
      Inflammation, Acute, Suppurative     | 2     2  3              3                                      2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        | 1  1  1  3  2           1                 1              1  1  2        1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +  +  +        +  +  +        +      |             
      Cataract                             |                                     4  2  3        3  4  4        4      |             
      Lids, Fibrosis, Focal                |                                                                          |             
      Posterior Chamber, Hemorrhage        |                                        3                                 |             
      Retina, Degeneration                 |                                     4  4  4        3  3  4        4      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                      2   |             
      Metaplasia, Osseous                  |                                                 2                        |             
      Nephropathy, Chronic                 | 2  2  3  2  3  1  4  2  3  2  2  2  2  2  2  2  3  2  4  3  2  2  2  2  2|             
      Cortex, Cyst                         |                                                                   3      |             
      Cortex, Cyst, Multiple               |                   2                                                      |             
      Papilla, Necrosis                    |                                                                      2   |             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |       1           1                             1     1  1               |             
      Renal Tubule, Hyperplasia            |       2                                                                  |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                                                                      1   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                  +                                   +   |             
      Bulbourethral Gland, Congestion      |                                  2                                       |             
      Bulbourethral Gland, Dilatation      |                                  2                                   2   |             
      Bulbourethral Gland, Inflammation,   |                                                                          |             
           Subacute                        |                                                                      2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 8| 2| 2| 6| 2| 3| 3| 3| 3| 0| 2| 3| 3|             
                                           | 0| 6| 9| 9| 9| 1| 9| 9| 9| 9| 7| 8| 1| 9| 9| 3| 9| 2| 2| 2| 7| 0| 9| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       2     2  2     2                 2                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   | 2              1              1           1                              |             
      Angiectasis, Multifocal              |          2  1           2                                                |             
      Basophilic Focus                     |       X  X  X  X     X        X     X     X              X           X  X|             
      Basophilic Focus, Multiple           |                   X        X                                             |             
      Clear Cell Focus                     |                   X                                                      |             
      Degeneration, Cystic, Focal          | 2           1                                         2                  |             
      Degeneration, Cystic, Multifocal     |          2                                      2                        |             
      Eosinophilic Focus                   |             X                 X                       X                  |             
      Eosinophilic Focus, Multiple         |          X                                                               |             
      Fibrosis                             |                      3                                                   |             
      Granuloma, Multiple                  |       1        1     1     2     2  1                 1     1            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   2                                                      |             
      Mixed Cell Focus                     |             X                                                            |             
      Pigmentation, Hemosiderin            |                      4                                                   |             
      Pigmentation, Multifocal, Cholesterol|                                  3                                       |             
      Regeneration                         | 2  2                 1  1              2  1  2  1  2                     |             
      Thrombosis                           |                                                                          |             
      Biliary Tract, Proliferation         | 2  3  1  2  3  2  1  2  2  3  2  1  2  4  3  1  3  3  2  2  1  4  3  3  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                             +        +              +        +|             
      Fat, Inflammation, Chronic,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Fat, Necrosis, Focal                 |          4                             4                       3         |             
      Fat, Necrosis, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                               X                                          |             
      Acinus, Atrophy, Multifocal          | 3        2  1        1     2        1  3  1  1              1  1  3     2|             
      Acinus, Hyperplasia, Focal           |                                              1                           |             
      Acinus, Hyperplasia, Multifocal      |                         3                                                |             
      Artery, Inflammation, Subacute       |                                                                         2|             
      Duct, Cyst                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 8| 2| 2| 6| 2| 3| 3| 3| 3| 0| 2| 3| 3|             
                                           | 0| 6| 9| 9| 9| 1| 9| 9| 9| 9| 7| 8| 1| 9| 9| 3| 9| 2| 2| 2| 7| 0| 9| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer, Multiple                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |       +                                                                  |             
      Foreign Body, Multiple               |       2                                                                  |             
      Granuloma, Multiple                  |       2                                                                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  2  2     2  3  3     1  1     2  1  1  2     1  1  2  1  1  1|             
      Fibrosis, Focal                      |                                                                          |             
      Inflammation, Multifocal, Subacute   |                                                                          |             
      Mineralization, Multifocal           |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           | 2                       2                          2           1  3      |             
      Degeneration, Fatty, Multifocal      |                                     2                                    |             
      Hyperplasia, Focal                   |             1           2                 1  2                    2      |             
      Hyperplasia, Multifocal              |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                        2                             1   |             
      Capsule, Hemorrhage                  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    1     2  2     1     2  1                       2        1  1  1     2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       4  3        3           2  2     2  3  2     2        4  3     2   |             
      Pars Distalis, Cyst                  |    2                       2  2                                X         |             
      Pars Distalis, Hemorrhage            |                                     2                                    |             
      Pars Distalis, Hyperplasia, Focal    |    2                                2                                    |             
      Pars Distalis, Pigmentation,         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 8| 2| 2| 6| 2| 3| 3| 3| 3| 0| 2| 3| 3|             
                                           | 0| 6| 9| 9| 9| 1| 9| 9| 9| 9| 7| 8| 1| 9| 9| 3| 9| 2| 2| 2| 7| 0| 9| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
          Hemosiderin                      |                                                             2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                           2                          2   |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
      Inflammation, Subacute               |                         2                                         2      |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |       1        1     1  2           3  2  2  1  1  2  2     2  2     3   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                              2                           |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2  3                    2  2                                2      |             
      Mineralization                       |          2                                                               |             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Multifocal                       |                               1     2                          1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                      +                                                   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  2     2           1  3  2           3  2  2  3  2     2        3      |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      | 2                                                                        |             
      Mediastinal, Congestion              |                               3                                          |             
      Mediastinal, Ectasia                 |       2  2           2                 2                                 |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Mesenteric, Congestion               |                         3           2                                    |             
      Mesenteric, Ectasia                  |                                                                          |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 8| 2| 2| 6| 2| 3| 3| 3| 3| 0| 2| 3| 3|             
                                           | 0| 6| 9| 9| 9| 1| 9| 9| 9| 9| 7| 8| 1| 9| 9| 3| 9| 2| 2| 2| 7| 0| 9| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Pancreatic, Ectasia                  |    3                                                                     |             
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      |    1                                                                     |             
      Pancreatic, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     |    1                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     1                                    |             
      Ectasia                              |    2  2     2  2        1                    1     2           2        1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                           2     3                        |             
      Fibrosis, Multifocal                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular, Lipocyte      |                                                                          |             
      Necrosis, Focal                      |                                                 3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2        2                 2              2                     |             
      Duct, Cyst                           |    2  2                                2     2              4  4         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Subcutaneous Tissue, Abscess, Focal  | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                    2           4         |             
      Hemorrhage, Multifocal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |       2                                                                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                3         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 8| 2| 2| 6| 2| 3| 3| 3| 3| 0| 2| 3| 3|             
                                           | 0| 6| 9| 9| 9| 1| 9| 9| 9| 9| 7| 8| 1| 9| 9| 3| 9| 2| 2| 2| 7| 0| 9| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         | 2           2     2     2  2                                             |             
      Fungus                               | 3           2     3     1                             2  3  2            |             
      Inflammation, Acute, Suppurative     | 2           2     3     2  2                          2  2  2            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        | 1                                                                    1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +        +  +  +                    +     +  +              +|             
      Cataract                             |             3           3                       2     2  3              3|             
      Lids, Fibrosis, Focal                |                      3     3                                             |             
      Posterior Chamber, Hemorrhage        |                                                                          |             
      Retina, Degeneration                 |             4           3                       4     4  4              4|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy, Chronic                 | 2  2  3  2  3  3  3  3  4  2  2  3  2  2  3  2  2  3  3  2  3  3  2  2  2|             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Cyst, Multiple               |                         X                                                |             
      Papilla, Necrosis                    |                                                                          |             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |                      1  1                                                |             
      Renal Tubule, Hyperplasia            |                      1                                                   |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Bulbourethral Gland, Congestion      |                                                                          |             
      Bulbourethral Gland, Dilatation      |                                                                          |             
      Bulbourethral Gland, Inflammation,   |                                                                          |             
           Subacute                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  49        |
      Parasite Metazoan                    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |      9  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Angiectasis, Focal                   |                                                                          |      5  1.2|
      Angiectasis, Multifocal              |                                                                          |      3  1.7|
      Basophilic Focus                     |                                                                          |     18     |
      Basophilic Focus, Multiple           |                                                                          |      3     |
      Clear Cell Focus                     |                                                                          |      2     |
      Degeneration, Cystic, Focal          |                                                                          |      7  1.6|
      Degeneration, Cystic, Multifocal     |                                                                          |      2  2.0|
      Eosinophilic Focus                   |                                                                          |      5     |
      Eosinophilic Focus, Multiple         |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  3.0|
      Granuloma, Multiple                  |                                                                          |     20  1.1|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2  2.0|
      Mixed Cell Focus                     |                                                                          |      2     |
      Pigmentation, Hemosiderin            |                                                                          |      1  4.0|
      Pigmentation, Multifocal, Cholesterol|                                                                          |      1  3.0|
      Regeneration                         |                                                                          |     16  1.8|
      Thrombosis                           |                                                                          |      1  3.0|
      Biliary Tract, Proliferation         |                                                                          |     49  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  11        |
      Fat, Inflammation, Chronic,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                                                                          |      5  3.8|
      Fat, Necrosis, Multifocal            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Basophilic Focus                     |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinus, Atrophy, Multifocal          |                                                                          |     24  1.7|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  1.0|
      Acinus, Hyperplasia, Multifocal      |                                                                          |      1  3.0|
      Artery, Inflammation, Subacute       |                                                                          |      1  2.0|
      Duct, Cyst                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Ulcer, Multiple                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Foreign Body, Multiple               |                                                                          |      1  2.0|
      Granuloma, Multiple                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Cardiomyopathy                       |                                                                          |     40  1.6|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      1  2.0|
      Mineralization, Multifocal           |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Degeneration, Fatty, Focal           |                                                                          |     11  1.7|
      Degeneration, Fatty, Multifocal      |                                                                          |      2  2.0|
      Hyperplasia, Focal                   |                                                                          |      8  1.4|
      Hyperplasia, Multifocal              |                                                                          |      2  1.5|
      Necrosis, Multifocal                 |                                                                          |      1  3.0|
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      2  1.5|
      Capsule, Hemorrhage                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia, Focal                   |                                                                          |     22  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  48        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Angiectasis           |                                                                          |     18  2.8|
      Pars Distalis, Cyst                  |                                                                          |      5  2.0|
      Pars Distalis, Hemorrhage            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      5  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Hyperplasia, Focal           |                                                                          |      4  1.8|
      Follicle, Cyst                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      4  2.8|
      Inflammation, Subacute               |                                                                          |      5  2.4|
      Duct, Cyst                           |                                                                          |      5  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |     31  1.6|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  50        |
      Dilatation                           |                                                                          |      2  2.5|
      Inflammation, Subacute               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
      Atrophy                              |                                                                          |     10  2.1|
      Mineralization                       |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia,      |                                                                          |            |
          Multifocal                       |                                                                          |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Hyperplasia                          |                                                                          |     19  2.5|
      Myelofibrosis                        |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Mediastinal, Congestion              |                                                                          |      2  2.5|
      Mediastinal, Ectasia                 |                                                                          |      4  2.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  4.0|
      Mesenteric, Congestion               |                                                                          |      2  2.5|
      Mesenteric, Ectasia                  |                                                                          |      1  2.0|
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |            |
           Multifocal                      |                                                                          |     50  1.1|
      Mesenteric, Pigmentation, Multifocal,|                                                                          |            |
           Cholesterol                     |                                                                          |     50  1.0|
      Pancreatic, Ectasia                  |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Pancreatic, Pigmentation, Multifocal,|                                                                          |            |
           Cholesterol                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
      Congestion                           |                                                                          |      1  1.0|
      Ectasia                              |                                                                          |     16  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Fibrosis, Focal                      |                                                                          |      6  2.0|
      Fibrosis, Multifocal                 |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Infiltration Cellular, Lipocyte      |                                                                          |      1  1.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  44        |
      Cyst                                 |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      5  2.0|
      Duct, Cyst                           |                                                                          |     13  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Subcutaneous Tissue, Abscess, Focal  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Compression                          |                                                                          |      3  3.0|
      Hemorrhage, Multifocal               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Foreign Body                         |                                                                          |      9  2.0|
      Fungus                               |                                                                          |     12  2.6|
      Inflammation, Acute, Suppurative     |                                                                          |     13  2.2|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |                                                                          |     13  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  15        |
      Cataract                             |                                                                          |     13  3.1|
      Lids, Fibrosis, Focal                |                                                                          |      2  3.0|
      Posterior Chamber, Hemorrhage        |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |     13  3.8|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |                                                                          |     50  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cortex, Cyst                         |                                                                          |      1  3.0|
      Cortex, Cyst, Multiple               |                                                                          |      2  2.0|
      Papilla, Necrosis                    |                                                                          |      1  2.0|
      Papilla, Transitional Epithelium,    |                                                                          |            |
           Hyperplasia                     |                                                                          |      7  1.0|
      Renal Tubule, Hyperplasia            |                                                                          |      2  1.5|
      Renal Tubule, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Bulbourethral Gland, Congestion      |                                                                          |      1  2.0|
      Bulbourethral Gland, Dilatation      |                                                                          |      2  2.0|
      Bulbourethral Gland, Inflammation,   |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 8| 1| 3| 3| 2| 9| 3| 3| 3| 1| 2| 2| 3| 3| 9| 1| 3| 3| 3| 7| 1| 5| 8| 0|             
                                           | 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 8| 3| 9| 0| 0| 0| 6| 0| 0| 0| 7| 2| 5| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            2                          2  2               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          2  2  2        2  2                                             |             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Subacute                         |                                                                      2   |             
      Lymphoid Tissue, Mineralization      |                                                                      2   |             
      Wall, Mineralization                 |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                       2                  |             
      Wall, Mineralization                 |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Subacute                         |                                                                      2   |             
      Lymphoid Tissue, Mineralization      |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Multifocal, Subacute   |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |       2        2  3     2  2     2  2     1  2  2              2     2  3|             
      Basophilic Focus                     |       X  X  X                       X                 X  X               |             
      Clear Cell Focus                     |                                                    X  X                  |             
      Congestion                           |                      2                                            2      |             
      Cyst                                 |                                     1                                    |             
      Degeneration, Cystic, Multifocal     |    2  3     3  3  3     2  3  1  4  2  2  1  2  3  1           2     3  3|             
      Eosinophilic Focus                   |                            X           X  X                 X            |             
      Eosinophilic Focus, Multiple         |    X  X     X  X  X     X     X  X  X        X  X  X     X     X  X  X  X|             
      Granuloma, Multiple                  |       2  1  1        2  2  2  1  2  1        2     1  2  2  1            |             
      Hepatodiaphragmatic Nodule           | 2                    2           2                                       |             
      Mixed Cell Focus                     |          X                                                               |             
      Mixed Cell Focus, Multiple           |    X                 X                                   X               |             
      Necrosis, Focal                      |                               1                                          |             
      Pigmentation, Multifocal, Cholesterol|                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                      2   |             
      Biliary Tract, Cyst                  |                   2                          2                           |             
      Biliary Tract, Proliferation         | 3  2  3  2  1  3  3  2  3  2  2  3  3  2  2  2  1  2  2  2  2  2  3  3  3|             
      Centrilobular, Necrosis              |                                                                         2|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +                       +                              |             
      Fat, Necrosis, Focal                 |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 8| 1| 3| 3| 2| 9| 3| 3| 3| 1| 2| 2| 3| 3| 9| 1| 3| 3| 3| 7| 1| 5| 8| 0|             
                                           | 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 8| 3| 9| 0| 0| 0| 6| 0| 0| 0| 7| 2| 5| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                1                                                         |             
      Acinus, Atrophy, Multifocal          | 2     1  1  3     2  2  2  1  2  4  2  1  3  2  1  2  2  3  3  2  1  3  3|             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Artery, Hypertrophy                  |                                                                          |             
      Artery, Inflammation, Subacute       |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                   2                             2                        |             
      Hyperplasia                          |                                                 2                        |             
      Inflammation, Subacute               |                   2              4              2                        |             
      Mineralization                       |                                                                      2   |             
      Ulcer                                |                                  4                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    2  2        2  2  2                       3        1              3  2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +                                      +              +        +   |             
      Abdominal, Hypertrophy               |                                                             3            |             
      Abdominal, Inflammation, Subacute    |                                                                          |             
      Abdominal, Mineralization            |       4                                      3                       3   |             
      Abdominal, Thrombosis                |                                                                          |             
      Aorta, Mineralization                |       4                                      3                       4   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       3  1  2  3  2  2  2  2  2  2  2  3  1  3  2  2  2     2  2  3  3  2|             
      Fibrosis, Focal                      | 2                                                                        |             
      Mineralization, Multifocal           |                                              2                       3   |             
      Atrium, Thrombosis                   | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty, Focal           |       1  1                    1     2                    1  2        1   |             
      Degeneration, Fatty, Multifocal      |                   2                                                      |             
      Hyperplasia, Focal                   |       2              2     2  2        2     2           1           4   |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                    2                     |             
      Pigmentation, Multifocal, Cholesterol|                                                    2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2  2                 2  2  2  2           2     2  1     1  1  2     2  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 8| 1| 3| 3| 2| 9| 3| 3| 3| 1| 2| 2| 3| 3| 9| 1| 3| 3| 3| 7| 1| 5| 8| 0|             
                                           | 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 8| 3| 9| 0| 0| 0| 6| 0| 0| 0| 7| 2| 5| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Multifocal              |       2  1        2                                               2      |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  3  1  2  3     1           2  3  2     3  3  1  1        4  2  3  3|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    3     3                                                  3     4      |             
      Pars Distalis, Cyst                  |             X  2              1                                          |             
      Pars Distalis, Hemorrhage            |                                                                   3      |             
      Pars Distalis, Hyperplasia, Focal    | 2                    2                    1     2                    2   |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                2                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Suppurative     |                2                                                         |             
      Ultimobranchial Cyst                 |                                                          2               |             
      C-Cell, Hyperplasia, Focal           |          1                                                        2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hyperplasia                          |                                                       1                  |             
      Inflammation, Subacute               |                                                 1                        |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               | 2  4        1  3  1           1  2  1     2  1           1  2  1     2   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1                    2                 3     2                  |             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Multifocal                       |                1                                1           1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2  2        2     2                    2  2  2  3        1   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              | 2                                   2        2                 2        2|             
      Mediastinal, Hyperplasia, Macrophage,|                                                                          |             
           Multifocal                      |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 8| 1| 3| 3| 2| 9| 3| 3| 3| 1| 2| 2| 3| 3| 9| 1| 3| 3| 3| 7| 1| 5| 8| 0|             
                                           | 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 8| 3| 9| 0| 0| 0| 6| 0| 0| 0| 7| 2| 5| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Congestion               |    2              3                                                      |             
      Mesenteric, Ectasia                  |                      2                       2        2                  |             
      Mesenteric, Fibrosis, Focal          |                                                                          |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 2  1  3  1  2  2  2  1  3  1  1  2  1  1  2  2  2  1  1  2  2  2  1  2  2|             
      Mesenteric, Necrosis, Focal          |       2                                                                  |             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 2  1  1  1  2  1  1  1  3  2  1  2  1  1  2  2  2  1  2  2  2  2  2  2  2|             
      Pancreatic, Ectasia                  |                                                             2            |             
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      |    2  2                                                     2            |             
      Pancreatic, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     |    2  2                                                     2            |             
      Renal, Hyperplasia, Macrophage,      |                                                                          |             
          Multifocal                       |                   2                                                      |             
      Renal, Pigmentation, Multifocal,     |                                                                          |             
           Cholesterol                     |                   1                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   2      |             
      Ectasia                              |          2              1  1  2     1              1     1           1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                        3                       3         |             
      Infiltration Cellular, Lipocyte      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     1                                      1                    2   |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Cyst                           |    4                                            2           2     2  2   |             
      Duct, Inflammation, Subacute         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    3  4  2  2  4  3  1           3  3  2     3  3  1  1        4  2  3  3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 8| 1| 3| 3| 2| 9| 3| 3| 3| 1| 2| 2| 3| 3| 9| 1| 3| 3| 3| 7| 1| 5| 8| 0|             
                                           | 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 8| 3| 9| 0| 0| 0| 6| 0| 0| 0| 7| 2| 5| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Pleura, Congestion, Multifocal       |          2                                                               |             
      Pleura, Fibrosis, Focal              | 3                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                2                                   2           2  2      |             
      Fungus                               |             3  3     3                             3     3  2  2  3      |             
      Inflammation, Acute, Suppurative     |             2  2     2                       1     2     2  2  2  2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |       1  1     1     1     1           2     1        1        1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +                                            +|             
                                            __________________________________________________________________________|             
   Eye                                     |    +                          +  +  +  +     +  +        +           +   |             
      Cataract                             |                               2  4  4  3     3  4        3               |             
      Retina, Degeneration                 |    2                          2  4  4  3     4  4        4           3   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 | 2  4  4  4  4  4  4  4  3  4  4  4  4  4  3  4  4  4  4  3  4  4  3  4  4|             
      Cortex, Cyst                         |          2                                            2                  |             
      Cortex, Cyst, Multiple               |       2     2  2  1  2           2  2                                    |             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |    1  2  2  2  1  1  1     1  2  1  1  2  1  2  2  2  2  1  1  1  1  2  1|             
      Renal Tubule, Hyperplasia            |                1                    1                          1         |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |       3                                      3                       4   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 6| 4| 7| 8| 3| 6| 2| 2| 2| 3| 8| 1| 2| 5| 3| 0| 1| 3| 3| 3| 5| 7| 9| 1| 2|             
                                           | 7| 3| 9| 2| 0| 6| 3| 9| 9| 0| 1| 2| 4| 8| 0| 5| 0| 0| 0| 0| 8| 8| 4| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          2               |             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Subacute                         |                                                                          |             
      Lymphoid Tissue, Mineralization      |                                                                          |             
      Wall, Mineralization                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             2                                            2     2         |             
      Wall, Mineralization                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Subacute                         |                                                                          |             
      Lymphoid Tissue, Mineralization      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Multifocal, Subacute   |          2                                                               |             
      Necrosis, Multifocal                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              | 2        2     2  2  2  2     2     2     2  2  2  1  2        1  2     2|             
      Basophilic Focus                     |                         X                                                |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic, Multifocal     | 2        2  2  3  3  3  3  2        2     3  2  3  2  3     2  1  2     3|             
      Eosinophilic Focus                   |                                                                          |             
      Eosinophilic Focus, Multiple         | X        X  X  X  X  X  X  X  X     X     X  X  X  X  X  X  X  X  X     X|             
      Granuloma, Multiple                  |             1  2  2  2     2  2  1  1           1  1  2     2     2      |             
      Hepatodiaphragmatic Nodule           |                   2                                         2            |             
      Mixed Cell Focus                     |    X           X  X        X  X                                   X      |             
      Mixed Cell Focus, Multiple           |                         X        X                    X  X  X            |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation, Multifocal, Cholesterol|                   1                                                      |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Biliary Tract, Cyst                  |                                                                          |             
      Biliary Tract, Proliferation         | 3  2  3  3  2  3  2  2  2  3  2  2  2  2  2  2  3  2  3  2  3  2  3  3  2|             
      Centrilobular, Necrosis              |       3                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +        +                    +   |             
      Fat, Necrosis, Focal                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 6| 4| 7| 8| 3| 6| 2| 2| 2| 3| 8| 1| 2| 5| 3| 0| 1| 3| 3| 3| 5| 7| 9| 1| 2|             
                                           | 7| 3| 9| 2| 0| 6| 3| 9| 9| 0| 1| 2| 4| 8| 0| 5| 0| 0| 0| 0| 8| 8| 4| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Acinus, Atrophy, Multifocal          | 3  1  1  1  2  2        2  2     3  3     3     2  2  2  2  1     1     2|             
      Acinus, Hyperplasia, Focal           |             2  2           1                          2                  |             
      Artery, Hypertrophy                  |                               3                                          |             
      Artery, Inflammation, Subacute       |             2                    2                    2                  |             
      Duct, Cyst                           |             2                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Multifocal          |                                     1                                    |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Mineralization                       | 3     2              2  1        2                             1        2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +        +                                +                              |             
      Abdominal, Hypertrophy               | 3        3                                3                              |             
      Abdominal, Inflammation, Subacute    |                                           3                              |             
      Abdominal, Mineralization            | 3                                                                        |             
      Abdominal, Thrombosis                | 3                                                                        |             
      Aorta, Mineralization                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1  2  2  2  3  2  2  1  2  3  2        2  3  1  2  2  1  2  3  2  3|             
      Fibrosis, Focal                      |                                                                          |             
      Mineralization, Multifocal           | 2                                      2                       1         |             
      Atrium, Thrombosis                   | 4              4                                4                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           2                              |             
      Degeneration, Fatty, Focal           |          2  1  1     2  2           1  2                 1               |             
      Degeneration, Fatty, Multifocal      |                                                                          |             
      Hyperplasia, Focal                   |             1  2           2                          2  2  1        2  2|             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Pigmentation, Multifocal, Cholesterol|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |             2  2           2        2        2           2        2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 6| 4| 7| 8| 3| 6| 2| 2| 2| 3| 8| 1| 2| 5| 3| 0| 1| 3| 3| 3| 5| 7| 9| 1| 2|             
                                           | 7| 3| 9| 2| 0| 6| 3| 9| 9| 0| 1| 2| 4| 8| 0| 5| 0| 0| 0| 0| 8| 8| 4| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Multifocal              |                                                             1            |             
      Thrombosis                           |                               X                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3     2  3  2  2  3  3  3     1  3        2        1  1  2     3     1  2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    3              3                                               3      |             
      Pars Distalis, Cyst                  |                X     2  1     2              1                           |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                2                       2                 2               |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |          3                 3                    2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                  2                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                       2                  |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Subacute               |                         1                       1     2                  |             
      Duct, Cyst                           |          3                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |    3        1  2              1     2        2  2           2            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                         1                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           2                    2        3|             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Multifocal                       | 1  2                          1     1     2                          2  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  2              2  2        2     2     2  2  2           2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |       2           2                             2     2                  |             
      Mediastinal, Hyperplasia, Macrophage,|                                                                          |             
           Multifocal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 6| 4| 7| 8| 3| 6| 2| 2| 2| 3| 8| 1| 2| 5| 3| 0| 1| 3| 3| 3| 5| 7| 9| 1| 2|             
                                           | 7| 3| 9| 2| 0| 6| 3| 9| 9| 0| 1| 2| 4| 8| 0| 5| 0| 0| 0| 0| 8| 8| 4| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Congestion               |                                                                          |             
      Mesenteric, Ectasia                  |                                                                          |             
      Mesenteric, Fibrosis, Focal          |          2                                2                              |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 2  1  2  2  1  2  2  1  2  2  2  1  3     3  1  2  3  2  2  2  1  2  2  2|             
      Mesenteric, Necrosis, Focal          |          2                                                               |             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 2  1  2  2  1  2  2  1  2  2  1  2  3     2  1  2  3  2  2  2  1  2  2  2|             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      |          2                                            2                  |             
      Pancreatic, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     |          2                                            2                  |             
      Renal, Hyperplasia, Macrophage,      |                                                                          |             
          Multifocal                       |                                                                          |             
      Renal, Pigmentation, Multifocal,     |                                                                          |             
           Cholesterol                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |    1        2  2     2  1     1     3           1        2  1     2  1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |          2     3  3  1              3                 3           3      |             
      Infiltration Cellular, Lipocyte      |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                                      |             
      Inflammation, Chronic                |                                                       3                  |             
      Duct, Cyst                           |    X                 1                 1              4     2     2      |             
      Duct, Inflammation, Subacute         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 4     3  4  2  3  4  4  3  1  2  4        2        1  1  3     2     1  3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 6| 4| 7| 8| 3| 6| 2| 2| 2| 3| 8| 1| 2| 5| 3| 0| 1| 3| 3| 3| 5| 7| 9| 1| 2|             
                                           | 7| 3| 9| 2| 0| 6| 3| 9| 9| 0| 1| 2| 4| 8| 0| 5| 0| 0| 0| 0| 8| 8| 4| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 4                                                  2                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                   3                                                      |             
      Pleura, Congestion, Multifocal       |                                                                          |             
      Pleura, Fibrosis, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          2                                            2              2   |             
      Fungus                               |          2                                            2  3           3   |             
      Inflammation, Acute, Suppurative     |          2                                            2  2           4   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        | 1     2  1  2  2  2              1  3     2           2  1  1        2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +  +           +   |             
      Cataract                             |                                                       3  4           3   |             
      Retina, Degeneration                 |                                                       3  4           3   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                             +      |             
      Inflammation, Acute, Suppurative     |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       | 2                                                                    2   |             
      Nephropathy, Chronic                 | 4  3  4  4  4  4  4  4  4  4  4  4  3  3  4     3  4  4  4  4  4  3  4  4|             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Cyst, Multiple               | 2        1     2  2  2           1        2              2               |             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     | 1     1  1  1  1  1  1  1  1  1  1     1  1     1  1  2     1     1  1  1|             
      Renal Tubule, Hyperplasia            |             1  1     1                             1                     |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       | 3                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 1| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |      6  2.0|
      Lymphoid Tissue, Inflammation,       |                                                                          |            |
          Subacute                         |                                                                          |      1  2.0|
      Lymphoid Tissue, Mineralization      |                                                                          |      1  2.0|
      Wall, Mineralization                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  49        |
      Parasite Metazoan                    |                                                                          |      4  2.0|
      Wall, Mineralization                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  49        |
      Lymphoid Tissue, Inflammation,       |                                                                          |            |
          Subacute                         |                                                                          |      1  2.0|
      Lymphoid Tissue, Mineralization      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  49        |
      Inflammation, Multifocal, Subacute   |                                                                          |      1  2.0|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Angiectasis, Multifocal              |                                                                          |     29  2.0|
      Basophilic Focus                     |                                                                          |      7     |
      Clear Cell Focus                     |                                                                          |      2     |
      Congestion                           |                                                                          |      2  2.0|
      Cyst                                 |                                                                          |      1  1.0|
      Degeneration, Cystic, Multifocal     |                                                                          |     36  2.4|
      Eosinophilic Focus                   |                                                                          |      4     |
      Eosinophilic Focus, Multiple         |                                                                          |     37     |
      Granuloma, Multiple                  |                                                                          |     27  1.6|
      Hepatodiaphragmatic Nodule           |                                                                          |      5  2.0|
      Mixed Cell Focus                     |                                                                          |      7     |
      Mixed Cell Focus, Multiple           |                                                                          |      8     |
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Pigmentation, Multifocal, Cholesterol|                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 1| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Biliary Tract, Cyst                  |                                                                          |      2  2.0|
      Biliary Tract, Proliferation         |                                                                          |     50  2.4|
      Centrilobular, Necrosis              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Fat, Necrosis, Focal                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Basophilic Focus                     |                                                                          |      1  1.0|
      Acinus, Atrophy, Multifocal          |                                                                          |     41  2.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      4  1.8|
      Artery, Hypertrophy                  |                                                                          |      1  3.0|
      Artery, Inflammation, Subacute       |                                                                          |      3  2.0|
      Duct, Cyst                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Acinus, Atrophy, Multifocal          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Edema                                |                                                                          |      2  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      3  2.7|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  49        |
      Mineralization                       |                                                                          |     16  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   7        |
      Abdominal, Hypertrophy               |                                                                          |      4  3.0|
      Abdominal, Inflammation, Subacute    |                                                                          |      1  3.0|
      Abdominal, Mineralization            |                                                                          |      4  3.3|
      Abdominal, Thrombosis                |                                                                          |      1  3.0|
      Aorta, Mineralization                |                                                                          |      4  3.5|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Cardiomyopathy                       |                                                                          |     45  2.1|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Mineralization, Multifocal           |                                                                          |      5  2.0|
      Atrium, Thrombosis                   |                                                                          |      4  3.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 1| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Degeneration, Fatty, Focal           |                                                                          |     15  1.4|
      Degeneration, Fatty, Multifocal      |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |     16  1.9|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Pigmentation, Multifocal, Cholesterol|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia, Focal                   |                                                                          |     21  1.9|
      Hyperplasia, Multifocal              |                                                                          |      5  1.6|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  49        |
      Hyperplasia                          |                                                                          |     34  2.2|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      7  3.1|
      Pars Distalis, Cyst                  |                                                                          |      8  1.5|
      Pars Distalis, Hemorrhage            |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      8  1.9|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Inflammation, Acute, Suppurative     |                                                                          |      1  2.0|
      Ultimobranchial Cyst                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Focal           |                                                                          |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Subacute               |                                                                          |      4  1.3|
      Duct, Cyst                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 1| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Subacute               |                                                                          |     22  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
      Atrophy                              |                                                                          |      7  2.1|
      Interstitial Cell, Hyperplasia,      |                                                                          |            |
          Multifocal                       |                                                                          |     10  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
      Hyperplasia                          |                                                                          |     19  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Mediastinal, Congestion              |                                                                          |      9  2.0|
      Mediastinal, Hyperplasia, Macrophage,|                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Mesenteric, Congestion               |                                                                          |      2  2.5|
      Mesenteric, Ectasia                  |                                                                          |      3  2.0|
      Mesenteric, Fibrosis, Focal          |                                                                          |      2  2.0|
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |            |
           Multifocal                      |                                                                          |     49  1.8|
      Mesenteric, Necrosis, Focal          |                                                                          |      2  2.0|
      Mesenteric, Pigmentation, Multifocal,|                                                                          |            |
           Cholesterol                     |                                                                          |     49  1.7|
      Pancreatic, Ectasia                  |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |            |
           Multifocal                      |                                                                          |      5  2.0|
      Pancreatic, Pigmentation, Multifocal,|                                                                          |            |
           Cholesterol                     |                                                                          |      5  2.0|
      Renal, Hyperplasia, Macrophage,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Renal, Pigmentation, Multifocal,     |                                                                          |            |
           Cholesterol                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |     20  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Fibrosis, Focal                      |                                                                          |      9  2.7|
      Infiltration Cellular, Lipocyte      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 1| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  48        |
      Hyperplasia                          |                                                                          |      5  1.4|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Duct, Cyst                           |                                                                          |     11  2.2|
      Duct, Inflammation, Subacute         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Hyperplasia, Focal                   |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Fibrous Osteodystrophy               |                                                                          |     36  2.6|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Compression                          |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Pleura, Congestion, Multifocal       |                                                                          |      1  2.0|
      Pleura, Fibrosis, Focal              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Foreign Body                         |                                                                          |      7  2.0|
      Fungus                               |                                                                          |     12  2.7|
      Inflammation, Acute, Suppurative     |                                                                          |     13  2.1|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |                                                                          |     22  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 1| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cataract                             |                                                                          |     10  3.3|
      Retina, Degeneration                 |                                                                          |     12  3.3|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   3        |
      Inflammation, Acute, Suppurative     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  49        |
      Hydronephrosis                       |                                                                          |      2  2.0|
      Nephropathy, Chronic                 |                                                                          |     49  3.8|
      Cortex, Cyst                         |                                                                          |      2  2.0|
      Cortex, Cyst, Multiple               |                                                                          |     15  1.8|
      Papilla, Transitional Epithelium,    |                                                                          |            |
           Hyperplasia                     |                                                                          |     43  1.3|
      Renal Tubule, Hyperplasia            |                                                                          |      7  1.0|
      Renal Tubule, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 9| 3| 3| 9| 3| 3| 3| 3| 8| 1| 1| 3| 3| 7| 8| 2| 3| 3| 2| 9| 0| 3| 3|             
                                           | 0| 6| 5| 0| 0| 8| 0| 0| 0| 0| 7| 0| 8| 1| 1| 6| 2| 2| 1| 1| 9| 0| 8| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Parasite Metazoan                    |                2                                                         |             
      Artery, Inflammation, Subacute       |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |       1                                                                  |             
      Angiectasis, Multifocal              |          1  2           2           2        1     2              2     1|             
      Basophilic Focus                     |                                                       X              X  X|             
      Basophilic Focus, Multiple           |                                                                   X      |             
      Clear Cell Focus                     |                                                       X                  |             
      Congestion                           |                                                 2                        |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic, Focal          |                            1                                2            |             
      Degeneration, Cystic, Multifocal     | 2     2  2  2  2  1  2  3           3        2     3  2  1     1  3  2  2|             
      Eosinophilic Focus                   |             X  X  X  X  X     X              X                 X         |             
      Eosinophilic Focus, Multiple         | X        X                          X              X  X           X  X  X|             
      Fibrosis                             |                                                                          |             
      Granuloma                            |                                                                          |             
      Granuloma, Multiple                  | 3  1     1  1        1  1  2           1  1  2        2  1  1  1  1  1  1|             
      Hepatodiaphragmatic Nodule           |             3                                                            |             
      Hepatodiaphragmatic Nodule, Multiple,|                                                                          |             
           Two                             |                                                                          |             
      Inflammation, Subacute               |                                                       3                  |             
      Mixed Cell Focus                     |             X        X        X  X                                   X  X|             
      Mixed Cell Focus, Multiple           |                   X        X                                             |             
      Necrosis, Multifocal                 |       2                                            2                     |             
      Pigmentation, Hemosiderin            |                                                       2                  |             
      Regeneration                         |                                                                          |             
      Biliary Tract, Proliferation         | 3  2  2  2  3  3  2  3  3  2  2  2  2  2  2  3  2  3  2  2  3  2  2  2  2|             
      Centrilobular, Necrosis              |                2                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +  +        +                              |             
      Fat, Necrosis, Focal                 |                               3  3                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X  X                                                     X         |             
      Acinus, Atrophy, Focal               |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 9| 3| 3| 9| 3| 3| 3| 3| 8| 1| 1| 3| 3| 7| 8| 2| 3| 3| 2| 9| 0| 3| 3|             
                                           | 0| 6| 5| 0| 0| 8| 0| 0| 0| 0| 7| 0| 8| 1| 1| 6| 2| 2| 1| 1| 9| 0| 8| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Atrophy, Multifocal          | 1     2     2     2        1     1  3  3  1     1  4  2  3     1  3  1  2|             
      Acinus, Hyperplasia, Focal           |                            2                    2        2               |             
      Duct, Cyst                           |       1                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Acinus, Hyperplasia, Multifocal      |                               3                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Edema                                | 3                                   2                                    |             
      Erosion                              |                                     2                                    |             
      Hyperplasia                          |                                     2              2                     |             
      Inflammation, Subacute               | 2                                   2              2                     |             
      Perforation                          |                                                                          |             
      Ulcer, Multiple                      | 3                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Edema                                | 3                                   2                                    |             
      Inflammation, Subacute               | 2                                   1                                    |             
      Mineralization                       |                                                    3              2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +              +      |             
      Abdominal, Hypertrophy               |                                                                          |             
      Abdominal, Inflammation, Subacute    |                                                                          |             
      Abdominal, Mineralization            |                                                                   2      |             
      Aorta, Mineralization                |                                                    4                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Cardiomyopathy                       | 2  1  2        2              2  2  1        2  3  3        1  2  3      |             
      Fibrosis, Focal                      |                                                                          |             
      Mineralization, Multifocal           |                                                    2                     |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           |          1  1        1        1        1           2                     |             
      Degeneration, Fatty, Multifocal      |    1              3                          2                           |             
      Hyperplasia, Focal                   |                2  1  1  2        1              3     2           2  1  1|             
      Hyperplasia, Multifocal              |             1                          2                                 |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Pigmentation, Multifocal, Cholesterol|                                                                          |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |          1                 2                       2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      2                    1  2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 9| 3| 3| 9| 3| 3| 3| 3| 8| 1| 1| 3| 3| 7| 8| 2| 3| 3| 2| 9| 0| 3| 3|             
                                           | 0| 6| 5| 0| 0| 8| 0| 0| 0| 0| 7| 0| 8| 1| 1| 6| 2| 2| 1| 1| 9| 0| 8| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Multifocal              |                         1                          2                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +           +  +  M  +        +  +  +        +  I  +      |             
      Hyperplasia                          |                            2        2              3              2      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +              +  +  +        +  +  +        +  +  +      |             
      Pars Distalis, Angiectasis           |             3                    3  2           2           1            |             
      Pars Distalis, Cyst                  |    X        2                    2              X                        |             
      Pars Distalis, Hemorrhage            |                                  3           3                           |             
      Pars Distalis, Hyperplasia, Focal    |       1                                                                  |             
      Pars Distalis, Necrosis              |                                              2                           |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                  2  1                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Ultimobranchial Cyst                 |                                                             2            |             
      C-Cell, Hyperplasia, Focal           | 1                                                                        |             
      Follicle, Cyst                       |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +        +        +     +  +  +        +  +  +        +  +  +  +   |             
      Inflammation, Subacute               | 2                                            2              2            |             
      Duct, Cyst                           |                         X                                            X   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Inflammation, Subacute               | 2     2                       2  2  2        2  2           3  1  2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2  2  2     2           2                       2      |             
      Hemorrhage                           |                                                             2            |             
      Mineralization                       |                                                                   2      |             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Multifocal                       |    2                    2                             2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                +                                                         |             
      Leukocytosis                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Hyperplasia                          |                2                                2  2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Congestion                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 9| 3| 3| 9| 3| 3| 3| 3| 8| 1| 1| 3| 3| 7| 8| 2| 3| 3| 2| 9| 0| 3| 3|             
                                           | 0| 6| 5| 0| 0| 8| 0| 0| 0| 0| 7| 0| 8| 1| 1| 6| 2| 2| 1| 1| 9| 0| 8| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Axillary, Ectasia                    |                                                                          |             
      Mediastinal, Amyloid Deposition      |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Ectasia                 |                            2           2                                 |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Mesenteric, Ectasia                  |                            2        2                                    |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 1  1  1  2  1  2  2  2  1  1  2  3  1     3  2  1  3  2  1  2  2  1  1  1|             
      Mesenteric, Necrosis, Focal          |                      2           2                                       |             
      Mesenteric, Necrosis, Multifocal     |                                                                          |             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 1  1  1  2  1  2  2  2  1  1  2  3  1     1  1  1  3  2  1  1  2  1  1  1|             
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      |                                                    2              2      |             
      Pancreatic, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     |                                                    2              2      |             
      Renal, Congestion                    |                                                                          |             
      Renal, Hyperplasia, Macrophage,      |                                                                          |             
          Multifocal                       |                                                                          |             
      Renal, Pigmentation, Multifocal,     |                                                                          |             
           Cholesterol                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                           |             
      Ectasia                              |    3     2  2     2     1                             1        1  2  1  1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                               3                       3        3  2      |             
      Fibrosis, Multifocal                 |                                           2                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        M              +  +  +        +  +  +        M  +  +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +        +              +  +  +        +  +  +  +     +  +  +      |             
      Hyperplasia                          |                                                                   2      |             
      Duct, Cyst                           | 1  1                             2  2           2           1     1      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Multifocal           |                                                                          |             
      Hyperplasia, Focal                   |             2                             2                              |             
      Hyperplasia, Multifocal              |                                                                          |             
      Inflammation, Multifocal, Subacute   |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 9| 3| 3| 9| 3| 3| 3| 3| 8| 1| 1| 3| 3| 7| 8| 2| 3| 3| 2| 9| 0| 3| 3|             
                                           | 0| 6| 5| 0| 0| 8| 0| 0| 0| 0| 7| 0| 8| 1| 1| 6| 2| 2| 1| 1| 9| 0| 8| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Fibrous Osteodystrophy               |                                     2              3           1  2      |             
      Cranium, Hypertrophy, Focal          |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Compression                          |                                  2                          2            |             
      Hemorrhage, Multifocal               | 2  3                                         2                           |             
      Necrosis, Focal                      |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
      Foreign Body                         |                               2              2              2  2  2      |             
      Fungus                               |                3              3              2              2  2  3      |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute, Suppurative     | 1              3              2              2              2  2  3      |             
      Nasolacrimal Duct, Foreign Body      |    1                                                                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |    3                             1                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +        +                       +  +  +     +  +  +  +               |             
      Cataract                             |             3                       3  2  2     2  3  3  3               |             
      Anterior Chamber, Hemorrhage         |                                     3                                    |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Acute, Suppurative               |    3                                                                     |             
      Conjunctiva, Inflammation, Acute,    |                                                                          |             
           Suppurative                     |    3                                                                     |             
      Cornea, Inflammation, Acute,         |                                                                          |             
          Suppurative                      |    2                                                                     |             
      Cornea, Inflammation, Subacute       |             2                                                            |             
      Posterior Chamber, Hemorrhage        |                                                                          |             
      Retina, Degeneration                 |             3                       3  2  3     3  3  3  3               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  2  3  4  4  3  4  4  4  4  4  3  4  4  4  3  4  4  4  4  3  4  4  3  4|             
      Cortex, Cyst                         |             2           2  2              2           2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 7| 9| 3| 3| 9| 3| 3| 3| 3| 8| 1| 1| 3| 3| 7| 8| 2| 3| 3| 2| 9| 0| 3| 3|             
                                           | 0| 6| 5| 0| 0| 8| 0| 0| 0| 0| 7| 0| 8| 1| 1| 6| 2| 2| 1| 1| 9| 0| 8| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cortex, Cyst, Multiple               |                                     2              2     2               |             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |       1  1  1     1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  2  1  1|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Hyperplasia            |                            1                                      1      |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                                                    3                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +              +  +  +        +  +  +        +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 7| 7| 3| 3| 3| 1| 8| 3| 3| 3| 0| 1| 1| 3| 3|             
                                           | 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 5| 8| 1| 1| 1| 0| 2| 1| 1| 1| 8| 0| 4| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +              +              +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +              +              +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +              A              +  +           A  +           +  +  A      |             
      Parasite Metazoan                    |                                                                          |             
      Artery, Inflammation, Subacute       |                                                                3         |             
      Artery, Necrosis, Fibrinoid          |                                                                3         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +              +              +  +           +  +           +  +  +      |             
      Parasite Metazoan                    |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +              +              +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +              +              +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +              +              +  +           A  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +              A              +  +           A  +           +  +  A      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +              A              +  +           +  +           +  +  A      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                2           2        2                                    |             
      Angiectasis, Multifocal              |    2     1  2        2                    2     2  2  2  2  2  2  2  2   |             
      Basophilic Focus                     |       X  X     X  X     X              X              X  X  X            |             
      Basophilic Focus, Multiple           |                                                                          |             
      Clear Cell Focus                     |                                     X                                    |             
      Congestion                           |                                                                          |             
      Cyst                                 |          3                                                               |             
      Degeneration, Cystic, Focal          |                2  2              2                                       |             
      Degeneration, Cystic, Multifocal     | 2  3     2  2        2  2  2           2  2     2  2  3  2  2  2  2  2  2|             
      Eosinophilic Focus                   |          X        X        X                    X              X     X   |             
      Eosinophilic Focus, Multiple         |    X        X  X        X        X  X  X  X        X  X  X  X     X     X|             
      Fibrosis                             |                                                 2                        |             
      Granuloma                            |                               1                                          |             
      Granuloma, Multiple                  |    1  1  1  1     1     1              1        1  1     1               |             
      Hepatodiaphragmatic Nodule           |          3        2     2                             2                  |             
      Hepatodiaphragmatic Nodule, Multiple,|                                                                          |             
           Two                             |             2                                                            |             
      Inflammation, Subacute               |                                                                          |             
      Mixed Cell Focus                     |          X  X              X           X        X  X     X        X     X|             
      Mixed Cell Focus, Multiple           |                         X           X     X           X                  |             
      Necrosis, Multifocal                 |          1                                      2                        |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Regeneration                         |                      1                                                   |             
      Biliary Tract, Proliferation         | 2  2  2  2  2  2  2  2  3  2  2  2  2  2  2     3  2  2  2  2  2  3  2  2|             
      Centrilobular, Necrosis              | 1                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                       +        +               |             
      Fat, Necrosis, Focal                 |                                                          3               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X        X     X                                    |             
      Acinus, Atrophy, Focal               |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 7| 7| 3| 3| 3| 1| 8| 3| 3| 3| 0| 1| 1| 3| 3|             
                                           | 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 5| 8| 1| 1| 1| 0| 2| 1| 1| 1| 8| 0| 4| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Atrophy, Multifocal          | 2     2     2     4  2  1  2     2  2  2  1     3  4  2  1  1  2  2  2  3|             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +              +              +  +           +  +           +  +  +      |             
      Acinus, Hyperplasia, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +              +              +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +              +              +  +           +  +           +  +  +      |             
      Edema                                |                                                                2         |             
      Erosion                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Subacute               |                                                             4  2         |             
      Perforation                          |                                                             4            |             
      Ulcer, Multiple                      |                                                             4            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +              +              +  +           +  +           +  +  +      |             
      Edema                                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Mineralization                       | 2                                                           2  2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                                                              +  +      |             
      Abdominal, Hypertrophy               |                                                                4  2      |             
      Abdominal, Inflammation, Subacute    |                                                                   3      |             
      Abdominal, Mineralization            |                                                                          |             
      Aorta, Mineralization                | 2                                                                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +     +           +  +  +        +  +  +  +        +  +  +      |             
      Cardiomyopathy                       | 3  2           3                 2           3  3           2  3  4      |             
      Fibrosis, Focal                      |    3                                                                     |             
      Mineralization, Multifocal           | 2                                                                        |             
      Atrium, Thrombosis                   | 3        3                 3              3        4                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           |                         2     1        1                       2  2      |             
      Degeneration, Fatty, Multifocal      |                                           2                              |             
      Hyperplasia, Focal                   |                                     2  1  1           3                  |             
      Hyperplasia, Multifocal              |    1     2                                                               |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                         2           2                                    |             
      Pigmentation, Multifocal, Cholesterol|                         1           1                                    |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                         X                 2                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                1                 1                       3  2  2     1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 7| 7| 3| 3| 3| 1| 8| 3| 3| 3| 0| 1| 1| 3| 3|             
                                           | 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 5| 8| 1| 1| 1| 0| 2| 1| 1| 1| 8| 0| 4| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Multifocal              |                         2                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +              +              +  +           +  +           +  +  +      |             
      Hyperplasia                          | 2                                               1           2  4  2      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +              +              +  +  +        +  +     +     +  +  +      |             
      Pars Distalis, Angiectasis           |                                     3                                    |             
      Pars Distalis, Cyst                  |                                                                X         |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                               2                                          |             
      Pars Distalis, Necrosis              |                                     2                                    |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +           +              +  +           +  +           +  +  +      |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +              +        +     +  +           +  +           +  +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +              +     +        +  +           +  +           +  +  +      |             
      Inflammation, Subacute               |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +              +              +  +           +  +           +  +  +      |             
      Inflammation, Subacute               | 2                             2              2  2           2            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +              +              +  +           +  +           +  +  +      |             
      Hyperplasia, Focal                   |                                                                   2      |             
      Inflammation, Subacute               |                                              2                           |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Atrophy                              |                            3              1                              |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Multifocal                       | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +              +              +  +           +  +           +  +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Congestion                 |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 7| 7| 3| 3| 3| 1| 8| 3| 3| 3| 0| 1| 1| 3| 3|             
                                           | 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 5| 8| 1| 1| 1| 0| 2| 1| 1| 1| 8| 0| 4| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Axillary, Ectasia                    |                            2                                             |             
      Mediastinal, Amyloid Deposition      |                                                 3                        |             
      Mediastinal, Congestion              |          2     2        2     3  2                             2         |             
      Mediastinal, Ectasia                 |                            2                    2     2                  |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                         2                                                |             
      Mesenteric, Ectasia                  |                                                       2     2        2   |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 1  1  1  2  2  2  1  2  3  1  1  1  2  1  1     2  2  2  1  1  1  2  2  2|             
      Mesenteric, Necrosis, Focal          |                                                                          |             
      Mesenteric, Necrosis, Multifocal     |                         1                                                |             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 1  1  1  2  2  1  1  2  3  1  1  1  1  1  1     1  2  2  1  1  1  1  1  1|             
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      |                                     3                                    |             
      Pancreatic, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     |                                     2                                    |             
      Renal, Congestion                    |                            2                                             |             
      Renal, Hyperplasia, Macrophage,      |                                                                          |             
          Multifocal                       |                            2                                             |             
      Renal, Pigmentation, Multifocal,     |                                                                          |             
           Cholesterol                     |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |    2        1     1        1           2                       2         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                               3                 3     3     1            |             
      Fibrosis, Multifocal                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | M              +              +  +           +  +           +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +              +              +  +           +  +           +  +  +  +   |             
      Hyperplasia                          |                               2                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Multifocal           |                                                       4                  |             
      Hyperplasia, Focal                   |                                     2           2                        |             
      Hyperplasia, Multifocal              |                                                       4                  |             
      Inflammation, Multifocal, Subacute   |                                                       3                  |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 7| 7| 3| 3| 3| 1| 8| 3| 3| 3| 0| 1| 1| 3| 3|             
                                           | 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 5| 8| 1| 1| 1| 0| 2| 1| 1| 1| 8| 0| 4| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +              +              +  +           +  +           +  +  +      |             
      Fibrous Osteodystrophy               | 2                                                           2  2  2      |             
      Cranium, Hypertrophy, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +              +              +  +           +  +           +  +  +      |             
      Compression                          |                                                                          |             
      Hemorrhage, Multifocal               |                                              3                           |             
      Necrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                2                                                         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |          2  3                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +              +              +  +           +  +           +  +  +      |             
      Foreign Body                         |                2                                               2         |             
      Fungus                               |                3                             3                 3         |             
      Hyperkeratosis                       |                                                                2         |             
      Inflammation, Acute, Suppurative     |                2                             3                 2         |             
      Nasolacrimal Duct, Foreign Body      |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +              +              +  +           +  +           +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +              +  +  +  +  +            |             
      Cataract                             |                                  2              3  4  4  4  4            |             
      Anterior Chamber, Hemorrhage         |                                                          3               |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Acute, Suppurative               |                                                                          |             
      Conjunctiva, Inflammation, Acute,    |                                                                          |             
           Suppurative                     |                                                                          |             
      Cornea, Inflammation, Acute,         |                                                                          |             
          Suppurative                      |                                                                          |             
      Cornea, Inflammation, Subacute       |                                                                          |             
      Posterior Chamber, Hemorrhage        |                                                          3               |             
      Retina, Degeneration                 |                                  2              3  4  4  4  4            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  4  3  3  4  3  3  3  4  4  3  2  4  4  4  3  4  4  3  4  4  4  4  4  4|             
      Cortex, Cyst                         |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 7| 7| 3| 3| 3| 1| 8| 3| 3| 3| 0| 1| 1| 3| 3|             
                                           | 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 5| 8| 1| 1| 1| 0| 2| 1| 1| 1| 8| 0| 4| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cortex, Cyst, Multiple               | 2  2                       1                                2            |             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     | 1  1  1  1  1  1     1  1  2  1        1  1     1  1  1  1  1  1  1  1  1|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                        4                                 |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       | 2                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +              +              +  +           +  +           +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 7| 7| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  19        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
      Artery, Inflammation, Subacute       |                                                                          |      1  3.0|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  22        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Angiectasis, Focal                   |                                                                          |      4  1.8|
      Angiectasis, Multifocal              |                                                                          |     21  1.8|
      Basophilic Focus                     |                                                                          |     12     |
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Clear Cell Focus                     |                                                                          |      2     |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  3.0|
      Degeneration, Cystic, Focal          |                                                                          |      5  1.8|
      Degeneration, Cystic, Multifocal     |                                                                          |     35  2.1|
      Eosinophilic Focus                   |                                                                          |     14     |
      Eosinophilic Focus, Multiple         |                                                                          |     22     |
      Fibrosis                             |                                                                          |      1  2.0|
      Granuloma                            |                                                                          |      1  1.0|
      Granuloma, Multiple                  |                                                                          |     27  1.2|
      Hepatodiaphragmatic Nodule           |                                                                          |      5  2.4|
      Hepatodiaphragmatic Nodule, Multiple,|                                                                          |            |
           Two                             |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                                                          |     15     |
      Mixed Cell Focus, Multiple           |                                                                          |      6     |
      Necrosis, Multifocal                 |                                                                          |      4  1.8|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Regeneration                         |                                                                          |      1  1.0|
      Biliary Tract, Proliferation         |                                                                          |     49  2.2|
      Centrilobular, Necrosis              |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 7| 7| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Fat, Necrosis, Focal                 |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  49        |
      Basophilic Focus                     |                                                                          |      6     |
      Acinus, Atrophy, Focal               |                                                                          |      2  1.0|
      Acinus, Atrophy, Multifocal          |                                                                          |     37  2.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      3  2.0|
      Duct, Cyst                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  22        |
      Acinus, Hyperplasia, Multifocal      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  22        |
      Edema                                |                                                                          |      3  2.3|
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Subacute               |                                                                          |      5  2.4|
      Perforation                          |                                                                          |      1  4.0|
      Ulcer, Multiple                      |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  22        |
      Edema                                |                                                                          |      2  2.5|
      Inflammation, Subacute               |                                                                          |      2  1.5|
      Mineralization                       |                                                                          |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   5        |
      Abdominal, Hypertrophy               |                                                                          |      2  3.0|
      Abdominal, Inflammation, Subacute    |                                                                          |      1  3.0|
      Abdominal, Mineralization            |                                                                          |      1  2.0|
      Aorta, Mineralization                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  27        |
      Cardiomyopathy                       |                                                                          |     22  2.3|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Mineralization, Multifocal           |                                                                          |      2  2.0|
      Atrium, Thrombosis                   |                                                                          |      5  3.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Degeneration, Fatty, Focal           |                                                                          |     11  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 7| 7| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Degeneration, Fatty, Multifocal      |                                                                          |      4  2.0|
      Hyperplasia, Focal                   |                                                                          |     14  1.6|
      Hyperplasia, Multifocal              |                                                                          |      4  1.5|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.0|
      Pigmentation, Multifocal, Cholesterol|                                                                          |      2  1.0|
      Capsule, Accessory Adrenal Cortical  |                                                                          |            |
          Nodule                           |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia, Focal                   |                                                                          |      9  1.7|
      Hyperplasia, Multifocal              |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  21        |
      Hyperplasia                          |                                                                          |      9  2.2|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  25        |
      Pars Distalis, Angiectasis           |                                                                          |      6  2.3|
      Pars Distalis, Cyst                  |                                                                          |      5  2.0|
      Pars Distalis, Hemorrhage            |                                                                          |      2  3.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      2  1.5|
      Pars Distalis, Necrosis              |                                                                          |      2  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  23        |
      Ultimobranchial Cyst                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Focal           |                                                                          |      1  1.0|
      Follicle, Cyst                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  25        |
      Inflammation, Subacute               |                                                                          |      3  2.0|
      Duct, Cyst                           |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  22        |
      Inflammation, Subacute               |                                                                          |     15  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  22        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 7| 7| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Subacute               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  48        |
      Atrophy                              |                                                                          |      8  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia,      |                                                                          |            |
          Multifocal                       |                                                                          |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Leukocytosis                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  22        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Axillary, Congestion                 |                                                                          |      1  2.0|
      Axillary, Ectasia                    |                                                                          |      1  2.0|
      Mediastinal, Amyloid Deposition      |                                                                          |      1  3.0|
      Mediastinal, Congestion              |                                                                          |      6  2.2|
      Mediastinal, Ectasia                 |                                                                          |      5  2.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  2.0|
      Mesenteric, Ectasia                  |                                                                          |      5  2.0|
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |            |
           Multifocal                      |                                                                          |     48  1.6|
      Mesenteric, Necrosis, Focal          |                                                                          |      2  2.0|
      Mesenteric, Necrosis, Multifocal     |                                                                          |      1  1.0|
      Mesenteric, Pigmentation, Multifocal,|                                                                          |            |
           Cholesterol                     |                                                                          |     48  1.4|
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |            |
           Multifocal                      |                                                                          |      3  2.3|
      Pancreatic, Pigmentation, Multifocal,|                                                                          |            |
           Cholesterol                     |                                                                          |      3  2.0|
      Renal, Congestion                    |                                                                          |      1  2.0|
      Renal, Hyperplasia, Macrophage,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Renal, Pigmentation, Multifocal,     |                                                                          |            |
           Cholesterol                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
      Congestion                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 7| 7| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Ectasia                              |                                                                          |     16  1.6|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Fibrosis, Focal                      |                                                                          |      8  2.6|
      Fibrosis, Multifocal                 |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  19        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  24        |
      Hyperplasia                          |                                                                          |      2  2.0|
      Duct, Cyst                           |                                                                          |      7  1.4|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  47        |
      Hyperkeratosis, Multifocal           |                                                                          |      1  4.0|
      Hyperplasia, Focal                   |                                                                          |      4  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  4.0|
      Inflammation, Multifocal, Subacute   |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Subacute                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  22        |
      Fibrous Osteodystrophy               |                                                                          |      8  2.0|
      Cranium, Hypertrophy, Focal          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  22        |
      Compression                          |                                                                          |      2  2.0|
      Hemorrhage, Multifocal               |                                                                          |      4  2.5|
      Necrosis, Focal                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  22        |
      Foreign Body                         |                                                                          |      7  2.0|
      Fungus                               |                                                                          |      9  2.7|
      Hyperkeratosis                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 7| 7| 6| 6| 6| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute, Suppurative     |                                                                          |     10  2.2|
      Nasolacrimal Duct, Foreign Body      |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  22        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  15        |
      Cataract                             |                                                                          |     14  3.0|
      Anterior Chamber, Hemorrhage         |                                                                          |      2  3.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Acute, Suppurative               |                                                                          |      1  3.0|
      Conjunctiva, Inflammation, Acute,    |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Cornea, Inflammation, Acute,         |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
      Cornea, Inflammation, Subacute       |                                                                          |      1  2.0|
      Posterior Chamber, Hemorrhage        |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |     14  3.1|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Nephropathy, Chronic                 |                                                                          |     50  3.6|
      Cortex, Cyst                         |                                                                          |      6  2.2|
      Cortex, Cyst, Multiple               |                                                                          |      7  1.9|
      Papilla, Transitional Epithelium,    |                                                                          |            |
           Hyperplasia                     |                                                                          |     43  1.1|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  4.0|
      Renal Tubule, Hyperplasia            |                                                                          |      2  1.0|
      Renal Tubule, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  22        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M              +              +              +                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +              +              +              +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +              +              +              +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +              +              +              +                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +              +              +              +                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +              +              +              +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +              +              +              +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +              +              +              +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +              +              +              +                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |       2                       1  2              1                        |             
      Angiectasis, Multifocal              |    2        2              2           2              2  2  3  1  2  2  2|             
      Basophilic Focus                     |             X     X  X        X  X        X     X     X  X        X     X|             
      Basophilic Focus, Multiple           |       X  X                                                               |             
      Clear Cell Focus                     |       X                                   X                              |             
      Degeneration, Cystic, Focal          |       2                          2                                       |             
      Degeneration, Cystic, Multifocal     |    2        2     2        2  2     3  2        1     2  3  3  2  2  2  2|             
      Eosinophilic Focus                   |       X                    X  X  X     X  X     X                 X      |             
      Eosinophilic Focus, Multiple         |          X  X                                         X  2  X  X     X  X|             
      Granuloma, Multiple                  |       1  1     1  1  1              1  1  1     1  1     2     1  1      |             
      Hepatodiaphragmatic Nodule           |                         3                          2                     |             
      Inflammation, Subacute               |                         3                                                |             
      Mixed Cell Focus                     |                         X     X     X  X                          X      |             
      Mixed Cell Focus, Multiple           |       X                          X        X              X              X|             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                               4                                          |             
      Pigmentation, Hemosiderin            |                                  3                                       |             
      Vacuolization Cytoplasmic, Diffuse   |                2                                                         |             
      Biliary Tract, Proliferation         |    3  2  2  2  3  2  4  3  2  2  2  3  2  2        2  2  2  2  2  3  2  2|             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Fat, Necrosis, Focal                 |                                                                3         |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             X                                                            |             
      Acinus, Atrophy, Multifocal          |       1  1  1  2  3  4  1  2        2  2     2  1     2  2     2     4  1|             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Acinus, Hyperplasia, Multifocal      |                                                                          |             
      Artery, Inflammation, Subacute       |                                                                          |             
      Duct, Cyst                           |                                           1                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +              +              +              +                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +              +              +              +                           |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +              +              +              +                           |             
      Hyperplasia                          |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Subacute               |                3                                                         |             
      Ulcer                                |                3                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +              +              +              +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +              +              +              +                           |             
      Cardiomyopathy                       |                                                                          |             
      Atrium, Thrombosis                   |                3                             X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           |                1  2  2  2                                   2     2      |             
      Degeneration, Fatty, Multifocal      |                                                    2                     |             
      Hyperplasia, Focal                   |                      2                    2        2           2     3  2|             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |                                              X        2  2           2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |          2                                2           1                  |             
      Hyperplasia, Multifocal              |                   2                                                  2  1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +              +              +              +              +            |             
      Hyperplasia                          |                                                             3            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +        +  +        +  +           +  +                           |             
      Pars Distalis, Angiectasis           |    3  2        3           3              3                              |             
      Pars Distalis, Cyst                  |       2        3                                                         |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                   2           1                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |       1                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +              +              +              +                           |             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +              +              +              +                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +              +     +        +              +                          +|             
      Hyperplasia                          |                                                                         4|             
      Inflammation, Subacute               |                      2                                                  2|             
      Duct, Cyst                           |                      3                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                | +              +              +              +                           |             
      Inflammation, Subacute               |                2              2              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +              +              +              +                           |             
      Dilatation                           |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              |       2              3                 3     3        3  3  3            |             
      Interstitial Cell, Hyperplasia, Focal|       1                                                                  |             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Multifocal                       |                      2                                1     2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +              +              +              +                           |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                2                                                         |             
      Mediastinal, Ectasia                 |                                                 2                        |             
      Mesenteric, Ectasia                  |                            3           2                                 |             
      Mesenteric, Giant Cell               |                                     1                                    |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 1  1  2  1  1  1  1  1  2  1  2  2  3  1  1     1  1  1  1  2  1  2  2  1|             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 1  1  2  1  1  1  1  1  1  1  1  1  3  1  1     1  1  1  1  2  1  1  2  1|             
      Pancreatic, Amyloid Deposition       |                                                                          |             
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      |                2                                                         |             
      Pancreatic, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     |                2              1                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          2  2  1  2           2        1           1        1        1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |    3                                                        3            |             
      Necrosis, Focal                      |                                                                          |             
      Capsule, Cyst                        |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +              +              +              +                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +           +              +              +  +                        |             
      Hyperplasia                          |    2                                            2                        |             
      Duct, Cyst                           | 2              2                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +     +     +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperkeratosis, Focal                |                            3                                             |             
      Hyperplasia, Focal                   |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +              +              +              +                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +              +           +  +              +                           |             
      Hemorrhage, Multifocal               | 3                                                                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Suppurative     |                               2                                          |             
      Necrosis                             |                               2                                          |             
      Pigmentation, Hemosiderin, Multifocal|                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Bronchus, Fungus                     |                               4                                          |             
      Bronchus, Inflammation, Acute,       |                                                                          |             
          Suppurative                      |                               3                                          |             
      Pleura, Fibrosis, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +              +              +              +                           |             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute, Suppurative     |                               2                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +              +              +              +                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                             M|             
                                            __________________________________________________________________________|             
   Eye                                     |                               +  +  +  +  +     +     +  +               |             
      Cataract                             |                               3  4  4  4  2     3     4  3               |             
      Anterior Chamber, Hemorrhage         |                                           2                              |             
      Cornea, Fibrosis                     |                                                       2                  |             
      Cornea, Inflammation, Subacute       |                                                                          |             
      Posterior Chamber, Hemorrhage        |                                  1        2                              |             
      Retina, Degeneration                 |                               3  4  4  4  3     3     4  3               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |    3  3  3  3  3  3  3  3  3  2  3  3  3  3  3  4  3  3  3  4  3  4  3  4|             
      Cortex, Cyst                         |                                                                   2      |             
      Cortex, Cyst, Multiple               |                                                             2           3|             
      Papilla, Transitional Epithelium,    |                                                                          |             
           Hyperplasia                     |       1  1  1  1     1  1  1     1  1  1  1  1  1  1  1  1  1  1  1     1|             
      Renal Tubule, Hyperplasia            |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +              +              +              +                 +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 5| 4| 2| 2| 2| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +              +  +           +  +                          +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +              +  +           +  +                          +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +              +  +           +  +                          +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +              +  +           +  +                          +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +              +  +           +  +                          +            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +              +  +           +  +                          +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +              +  +           +  A                          +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +              +  +           +  A                          +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +              +  +           +  +                          +            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   | 2                                      2        2              2  2  2   |             
      Angiectasis, Multifocal              |    2     2                          2     2  2     2  2  2              2|             
      Basophilic Focus                     |          X                          X     X                              |             
      Basophilic Focus, Multiple           |                                                                          |             
      Clear Cell Focus                     |                X                                                         |             
      Degeneration, Cystic, Focal          |                                  2                                       |             
      Degeneration, Cystic, Multifocal     | 2  2  2  2           2  2           2  2  2  2  2  2  2  2     2  2  2  2|             
      Eosinophilic Focus                   |       X        X  X     X              X           X  X           X      |             
      Eosinophilic Focus, Multiple         | X  X     X           X     X        X     X  X  X        X     X     X  X|             
      Granuloma, Multiple                  |    1  1  1  1  1  1  1  1              1  1  2  3     2  1     1  1  1  1|             
      Hepatodiaphragmatic Nodule           |                                           3        2                    3|             
      Inflammation, Subacute               |                                                                          |             
      Mixed Cell Focus                     |       X                 X  X        X        X  X     X        X     X   |             
      Mixed Cell Focus, Multiple           |    X     X  X                          X           X                     |             
      Necrosis, Focal                      |                                           1                              |             
      Necrosis, Multifocal                 |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Biliary Tract, Proliferation         | 2  2  2  2  2  3  2  3  2  2  3  2  2  2  2  2  2  2  2  2     2     2  2|             
      Centrilobular, Necrosis              |                               3  2                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                             +  +  +  +                        |             
      Fat, Necrosis, Focal                 |                                        4  3  3                           |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                +         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                   X      |             
      Acinus, Atrophy, Multifocal          | 1  1  2        2  1  3     1        2     2     2  2  3        1     2  1|             
      Acinus, Hyperplasia, Focal           |                                     2                                    |             
      Acinus, Hyperplasia, Multifocal      |                                                                1         |             
      Artery, Inflammation, Subacute       |                            2                                             |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +              +  +           +  +                          +            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +              +  +           +  +                          +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +              +  +           +  +                          +            |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 109                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 5| 4| 2| 2| 2| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +              +  +           +  +                          +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +              +  +           +  +  +                       +            |             
      Cardiomyopathy                       | 3              2  1           3  2                          2            |             
      Atrium, Thrombosis                   |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           | 2              1     2  1           2     2                              |             
      Degeneration, Fatty, Multifocal      |                                                                          |             
      Hyperplasia, Focal                   |          2  1                                         1        2         |             
      Capsule, Accessory Adrenal Cortical  |                                                                          |             
          Nodule                           |             2                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2                                                                        |             
      Hyperplasia, Multifocal              |                                              2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +              +  +           +  +           +              +            |             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +              +  +        +  +  +                 +        +            |             
      Pars Distalis, Angiectasis           | 2                          2                       4        2            |             
      Pars Distalis, Cyst                  |                                  2                                       |             
      Pars Distalis, Hemorrhage            |                               4                                          |             
      Pars Distalis, Hyperplasia, Focal    |                2                                                         |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +              +  +  +        +  +                          +            |             
      C-Cell, Hyperplasia, Focal           |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +              +  +           +  +                          +            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +              +  +           +  +  +                       +            |             
      Hyperplasia                          |                                     3                                    |             
      Inflammation, Subacute               |                                     3                                    |             
      Duct, Cyst                           |                                     3                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +              +  +           +  +                          +            |             
      Inflammation, Subacute               | 2              2  1           2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 110                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 5| 4| 2| 2| 2| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +              +  +        +  +  +                          +            |             
      Dilatation                           |                            2                                             |             
      Inflammation, Subacute               |                            2                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                2  3        2     2        2                              |             
      Interstitial Cell, Hyperplasia, Focal|                1              1                                          |             
      Interstitial Cell, Hyperplasia,      |                                                                          |             
          Multifocal                       | 2                          2        2              1                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +              +  +           +  +                          +            |             
      Myelofibrosis                        |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                 2              2         |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mesenteric, Ectasia                  |          4                                   2     1  2                  |             
      Mesenteric, Giant Cell               |                                                                          |             
      Mesenteric, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      | 1  3  2  1  2  1  2  1  2  1  1  2  2  2  2  3  3  1  2  1     2     1  1|             
      Mesenteric, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     | 1  2  2  1  1  1  1  1  1  1  1  1  2  1  2  2  2  1  1  1     2     1  1|             
      Pancreatic, Amyloid Deposition       |                   2                                                      |             
      Pancreatic, Hyperplasia, Macrophage, |                                                                          |             
           Multifocal                      |                   2              2                                       |             
      Pancreatic, Pigmentation, Multifocal,|                                                                          |             
           Cholesterol                     |                   1              1                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          1     1  1  2  1           1           1  2                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |          2                                                              2|             
      Necrosis, Focal                      |                               3                                          |             
      Capsule, Cyst                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +              +  +           +  +                          +            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +              +  +        +  +  +                          +            |             
      Hyperplasia                          |                                                                          |             
      Duct, Cyst                           | 2                             2                             2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +           +  +  +  +  +     +  +        +  +     +        +            |             
      Hyperkeratosis, Focal                |                                              4                           |             
      Hyperplasia, Focal                   |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +              +  +           +  +                          +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 111                                                               
NTP Experiment-Test: 05019-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 06:45:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 6| 2| 2| 2| 2| 5| 4| 2| 2| 2| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.6%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Fibrosis, Focal                      |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +              +  +           +  +                          +            |             
      Hemorrhage, Multifocal               |                               2                             1            |