National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2886

TDMS Study 05021-04 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         CI PIGMENT RED 23


NTP Experiment-Test: 05021-04                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: DOSED FEED                                                                                                 Time: 23:04:54




       Facility:  Southern Research Institute

       Chemical CAS #:  6471-49-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          11            7           11           10                                     
    Dead                                               4            8            3            4                                     
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           34           36           35                                     
  Missing                                                                                     1                                     
  Animals Examined Microscopically                    50           50           50           49                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (15)         (14)         (48)                                   
      Inflammation, Chronic                                         2 (13%)                                                         
   Gallbladder                                        (46)         (12)         (12)         (46)                                   
      Epithelium, Cytoplasmic Alteration                                                      1 (2%)                                
      Wall, Mucocele                                   3 (7%)                                 1 (2%)                                
   Intestine Large, Cecum                             (47)         (47)         (48)         (46)                                   
      Lymphoid Tissue, Hyperplasia, Lymphoid           3 (6%)       5 (11%)      3 (6%)       2 (4%)                                
      Lymphoid Tissue, Pigmentation                                              2 (4%)       5 (11%)                               
      Submucosa, Edema                                 1 (2%)                                                                       
   Intestine Large, Rectum                            (46)         (48)         (48)         (46)                                   
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Polyarteritis                                                 1 (2%)                                                          
   Intestine Small, Duodenum                          (46)         (46)         (47)         (46)                                   
      Erosion                                                                    1 (2%)                                             
      Polyarteritis                                                 1 (2%)                                                          
      Submucosa, Inflammation, Acute                                                          1 (2%)                                
   Intestine Small, Ileum                             (46)         (45)         (48)         (46)                                   
      Lymphoid Tissue, Pigmentation                                              1 (2%)       1 (2%)                                
   Intestine Small, Jejunum                           (46)         (46)         (48)         (47)                                   
      Lymphoid Tissue, Hyperplasia, Lymphoid           2 (4%)       1 (2%)                                                          
      Lymphoid Tissue, Hyperplasia, Plasma Cell                                               1 (2%)                                
      Lymphoid Tissue, Hyperplasia, Re Cell                                                   1 (2%)                                
      Lymphoid Tissue, Pigmentation                                12 (26%)     25 (52%)     31 (66%)                               
   Liver                                              (49)         (49)         (50)         (48)                                   
      Clear Cell Focus                                                                        1 (2%)                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 9 (18%)      4 (8%)       7 (14%)      3 (6%)                                
      Inflammation, Acute                              2 (4%)       1 (2%)       2 (4%)       2 (4%)                                
      Inflammation, Chronic                            4 (8%)       2 (4%)                                                          
      Mitotic Alteration                                                         1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Polyarteritis                                                 1 (2%)                                                          
      Hepatocyte, Cytomegaly, Focal                    2 (4%)                                                                       
      Hepatocyte, Necrosis                             2 (4%)                    1 (2%)                                             
      Hepatocyte, Vacuolization Cytoplasmic            2 (4%)       3 (6%)       1 (2%)       1 (2%)                                
      Kupffer Cell, Hyperplasia                                                               1 (2%)                                
   Mesentery                                          (7)                       (4)          (3)                                    
      Inflammation, Acute                              2 (29%)                                                                      
      Inflammation, Chronic                            2 (29%)                                                                      
      Fat, Necrosis                                    3 (43%)                   2 (50%)      2 (67%)                               
   Pancreas                                           (49)         (14)         (15)         (47)                                   
      Cytoplasmic Alteration                                                                  1 (2%)                                
      Inflammation, Acute                              3 (6%)       1 (7%)                                                          
      Inflammation, Chronic                                                      1 (7%)                                             
      Polyarteritis                                                 1 (7%)                                                          
      Acinar Cell, Atrophy                             2 (4%)       3 (21%)      1 (7%)                                             
      Duct, Ectasia                                    3 (6%)       1 (7%)       1 (7%)       1 (2%)                                
      Perivascular, Inflammation, Chronic              1 (2%)                                                                       
   Salivary Glands                                    (49)         (16)         (14)         (49)                                   
      Inflammation, Acute                                           1 (6%)                                                          
   Stomach, Forestomach                               (49)         (49)         (50)         (49)                                   
      Abscess                                          4 (8%)       5 (10%)     28 (56%)     32 (65%)                               
      Angiectasis                                      1 (2%)                                                                       
      Hyperkeratosis                                   2 (4%)       1 (2%)       3 (6%)      18 (37%)                               
      Inflammation, Chronic                                                      2 (4%)       3 (6%)                                
      Ulcer                                            2 (4%)       6 (12%)     30 (60%)     38 (78%)                               
      Epithelium, Cyst                                                                        1 (2%)                                
      Epithelium, Hyperplasia                          4 (8%)       9 (18%)     27 (54%)     20 (41%)                               
      Epithelium, Hyperplasia, Multiple                2 (4%)       5 (10%)     16 (32%)     27 (55%)                               
      Submucosa, Edema                                                                        1 (2%)                                
   Stomach, Glandular                                 (48)         (48)         (50)         (45)                                   
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
      Mineralization                                   9 (19%)      4 (8%)       6 (12%)     10 (22%)                               
      Ulcer                                                                                   1 (2%)                                
      Mucosa, Cyst                                                  1 (2%)                                                          
      Mucosa, Hyperplasia                              2 (4%)                                                                       
      Submucosa, Edema                                                                        1 (2%)                                
   Tongue                                                                                    (1)                                    
      Angiectasis                                                                             1 (100%)                              
   Tooth                                              (2)                                                                           
      Incisor, Abscess                                 1 (50%)                                                                      
      Incisor, Developmental Malformation              1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                    (1)                                    
      Aorta, Polyarteritis                                                                    1 (100%)                              
      Pulmonary Artery, Inflammation, Acute            1 (100%)                                                                     
   Heart                                              (50)         (16)         (14)         (49)                                   
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            4 (8%)       1 (6%)       1 (7%)       2 (4%)                                
      Atrioventricular Valve, Thrombosis               1 (2%)                                                                       
      Epicardium, Fibrosis                             1 (2%)                                                                       
      Interstitium, Fibrosis                           4 (8%)                                 3 (6%)                                
      Myocardium, Degeneration                                                                2 (4%)                                
      Myocardium, Inflammation                                      1 (6%)                                                          
      Myocardium, Inflammation, Acute                               1 (6%)                                                          
      Myocardium, Mineralization                       1 (2%)       1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (15)         (14)         (48)                                   
      Congestion                                                    1 (7%)                                                          
      Hematopoietic Cell Proliferation                 2 (4%)                                                                       
      Hyperplasia, Focal                                                                      1 (2%)                                
      Hypertrophy, Diffuse                                                       1 (7%)                                             
      Hypertrophy, Focal                               1 (2%)                                 2 (4%)                                
      Inflammation, Acute                              1 (2%)       1 (7%)                                                          
      Corticomedullary Junction, Pigmentation         46 (94%)                   3 (21%)     45 (94%)                               
      Extra Adrenal Tissue, Accessory Adrenal                                                                                       
          Cortical Nodule                              1 (2%)                    1 (7%)                                             
      Spindle Cell, Hyperplasia                       49 (100%)    14 (93%)     14 (100%)    47 (98%)                               
   Adrenal Gland, Medulla                             (49)         (15)         (14)         (47)                                   
      Hyperplasia                                      2 (4%)                    1 (7%)       3 (6%)                                
   Parathyroid Gland                                  (49)         (10)         (14)         (49)                                   
      Cyst                                             4 (8%)                                 3 (6%)                                
      Ectopic Thymus                                   1 (2%)                                 1 (2%)                                
   Pituitary Gland                                    (50)         (23)         (16)         (47)                                   
      Pars Distalis, Angiectasis                       1 (2%)       2 (9%)                    2 (4%)                                
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Degeneration, Cystic              2 (4%)                                 3 (6%)                                
      Pars Distalis, Hyperplasia                      10 (20%)      3 (13%)      2 (13%)     11 (23%)                               
      Pars Intermedia, Hyperplasia                                                            1 (2%)                                
   Thyroid Gland                                      (50)         (15)         (14)         (49)                                   
      Inflammation, Acute                              2 (4%)                                 1 (2%)                                
      Ultimobranchial Cyst                                          1 (7%)       1 (7%)       2 (4%)                                
      Follicle, Cyst                                   5 (10%)                                7 (14%)                               
      Follicular Cell, Hyperplasia                     6 (12%)      1 (7%)       1 (7%)      11 (22%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (47)         (20)         (28)         (48)                                   
      Abscess                                          8 (17%)      4 (20%)      2 (7%)       2 (4%)                                
      Atrophy                                         24 (51%)      6 (30%)      6 (21%)     28 (58%)                               
      Cyst                                             1 (2%)                    2 (7%)                                             
      Hyperplasia, Tubular                                                                    1 (2%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Pigmentation, Ceroid                            35 (74%)      9 (45%)     14 (50%)     43 (90%)                               
      Polyarteritis                                                 1 (5%)                                                          
      Follicle, Cyst                                  11 (23%)      1 (5%)      10 (36%)     13 (27%)                               
      Follicle, Hemorrhage                             1 (2%)                    1 (4%)       1 (2%)                                
      Periovarian Tissue, Cyst                         1 (2%)                    1 (4%)                                             
      Periovarian Tissue, Inflammation, Acute          2 (4%)                                                                       
      Periovarian Tissue, Inflammation, Chronic        2 (4%)                                 1 (2%)                                
   Uterus                                             (49)         (41)         (39)         (49)                                   
      Abscess                                          1 (2%)       1 (2%)                                                          
      Exudate, Purulent                                6 (12%)      1 (2%)                    4 (8%)                                
      Hemorrhage                                       1 (2%)       1 (2%)                    1 (2%)                                
      Hydrometra                                       5 (10%)      1 (2%)       3 (8%)       1 (2%)                                
      Polyarteritis                                                 1 (2%)                                                          
      Endometrium, Cyst                                             1 (2%)       3 (8%)                                             
      Endometrium, Hyperplasia, Cystic                41 (84%)     28 (68%)     29 (74%)     43 (88%)                               
      Endometrium, Inflammation, Acute                 2 (4%)       1 (2%)                    1 (2%)                                
      Endometrium, Inflammation, Chronic               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (49)         (49)                                   
      Hypocellularity                                  4 (8%)       2 (4%)                                                          
      Myelofibrosis                                   21 (43%)     14 (29%)     27 (55%)     26 (53%)                               
      Erythroid Cell, Hyperplasia                      1 (2%)                                                                       
      Myeloid Cell, Hyperplasia                       13 (27%)      7 (14%)      5 (10%)      7 (14%)                               
   Lymph Node                                         (50)         (48)         (50)         (49)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
      Iliac, Edema                                                  1 (2%)                                                          
      Iliac, Hyperplasia, Plasma Cell                  1 (2%)       1 (2%)                    2 (4%)                                
      Iliac, Inflammation, Chronic                     1 (2%)                                                                       
      Mediastinal, Abscess                                          1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Edema                                                                      1 (2%)                                
      Mediastinal, Hematopoietic Cell Proliferation    1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)                                 1 (2%)                                
      Mediastinal, Hyperplasia, Plasma Cell            3 (6%)       1 (2%)                                                          
      Mediastinal, Inflammation, Acute                 1 (2%)       1 (2%)                                                          
      Mediastinal, Inflammation, Chronic               2 (4%)                                                                       
      Mesenteric, Abscess                                                        1 (2%)                                             
      Mesenteric, Angiectasis                          1 (2%)                    2 (4%)                                             
      Mesenteric, Autolysis                            1 (2%)                                 2 (4%)                                
      Mesenteric, Hematopoietic Cell Proliferation     1 (2%)       2 (4%)       1 (2%)                                             
      Mesenteric, Hyperplasia, Lymphoid               11 (22%)     14 (29%)      8 (16%)      9 (18%)                               
      Mesenteric, Hyperplasia, Plasma Cell             2 (4%)       1 (2%)                                                          
      Mesenteric, Inflammation, Acute                  3 (6%)                    1 (2%)       1 (2%)                                
      Mesenteric, Inflammation, Chronic                2 (4%)                    1 (2%)                                             
      Mesenteric, Pigmentation                                      4 (8%)      26 (52%)     29 (59%)                               
      Mesenteric, Lymphocyte, Necrosis                              1 (2%)                                                          
      Pancreatic, Hyperplasia, Lymphoid                                          1 (2%)       1 (2%)                                
      Pancreatic, Inflammation, Granulomatous                                    1 (2%)                                             
      Renal, Abscess                                                1 (2%)                                                          
      Renal, Hyperplasia, Lymphoid                     1 (2%)                                                                       
      Renal, Hyperplasia, Plasma Cell                  2 (4%)       1 (2%)                    2 (4%)                                
      Renal, Inflammation, Acute                       1 (2%)                                                                       
      Renal, Lymphocyte, Necrosis                                                             1 (2%)                                
   Lymph Node, Mandibular                             (49)         (18)         (15)         (49)                                   
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                            4 (8%)                                                                       
      Inflammation, Acute                                           1 (6%)                    1 (2%)                                
      Inflammation, Granulomatous                                                             1 (2%)                                
      Arteriole, Amyloid Deposition                                                           1 (2%)                                
   Spleen                                             (50)         (21)         (25)         (48)                                   
      Angiectasis                                                                             1 (2%)                                
      Hematopoietic Cell Proliferation                23 (46%)      7 (33%)     15 (60%)     17 (35%)                               
      Hyperplasia, Lymphoid                            6 (12%)                   2 (8%)       9 (19%)                               
      Red Pulp, Depletion Cellular                                                            1 (2%)                                
   Thymus                                             (18)         (7)          (14)         (39)                                   
      Atrophy                                          1 (6%)       2 (29%)      2 (14%)      4 (10%)                               
      Cyst                                             3 (17%)                   2 (14%)      4 (10%)                               
      Hyperplasia, Lymphoid                                                      1 (7%)       2 (5%)                                
      Cortex, Necrosis                                 1 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (15)         (15)         (48)                                   
      Inflammation, Chronic                            2 (4%)                                                                       
      Acinus, Hyperplasia                                                        1 (7%)       3 (6%)                                
      Duct, Dilatation                                 1 (2%)                    1 (7%)       3 (6%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Duct, Ectasia                                                              1 (7%)                                             
   Skin                                               (49)         (48)         (48)         (49)                                   
      Dermis, Fibrosis                                 1 (2%)                                                                       
      Dermis, Inflammation, Acute                      2 (4%)       1 (2%)                                                          
      Dermis, Inflammation, Chronic                   25 (51%)     25 (52%)     28 (58%)     21 (43%)                               
      Epidermis, Pigmentation                                                                 1 (2%)                                
      Subcutaneous Tissue, Abscess                                                            1 (2%)                                
      Subcutaneous Tissue, Edema                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (15)         (14)         (49)                                   
      Cerebellum, Compression                          1 (2%)                                                                       
      Cerebrum, Compression                                                      1 (7%)       2 (4%)                                
      Cerebrum, Degeneration                                                                  1 (2%)                                
      Meninges, Infiltration Cellular, Lymphocyte      1 (2%)                                 1 (2%)                                
      Thalamus, Mineralization                        44 (88%)     12 (80%)      8 (57%)     35 (71%)                               
      Third Ventricle, Infiltration Cellular,                                                                                       
          Lipocyte                                     1 (2%)                                                                       
   Spinal Cord                                        (1)                                                                           
      Nerve, Demyelination                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (49)                                   
      Congestion                                                    1 (2%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                1 (2%)       1 (2%)                                                          
      Inflammation, Acute                              2 (4%)       2 (4%)                    1 (2%)                                
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              1 (2%)       1 (2%)                                             
      Alveolus, Mineralization                                      1 (2%)                                                          
      Artery, Foreign Body                                                       1 (2%)                                             
      Artery, Mineralization                                        1 (2%)       1 (2%)                                             
      Pleura, Inflammation, Acute                      1 (2%)                                                                       
      Pleura, Inflammation, Chronic                    4 (8%)                                 3 (6%)                                
   Nose                                               (50)         (15)         (14)         (49)                                   
      Exudate, Purulent                                                                       1 (2%)                                
      Foreign Body                                                                            1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Nasolacrimal Duct, Exudate, Purulent             1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)                                                                       
      Sinus, Exudate, Acute                                         1 (7%)                                                          
      Vomeronasal Organ, Inflammation, Acute                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)          (2)                                                 
      Phthisis Bulbi                                   1 (100%)                  2 (100%)                                           
      Cornea, Inflammation, Chronic                                 2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (17)         (15)         (49)                                   
      Casts Protein                                    7 (14%)                                6 (12%)                               
      Infarct, Chronic                                 3 (6%)       1 (6%)                    1 (2%)                                
      Nephropathy                                     24 (49%)      2 (12%)      1 (7%)      26 (53%)                               
      Cortex, Metaplasia, Osseous                      2 (4%)                                 6 (12%)                               
      Corticomedullary Junction, Embolus Bacterial,                                                                                 
           Focal                                       1 (2%)                                                                       
      Glomerulus, Amyloid Deposition                                                          1 (2%)                                
      Glomerulus, Inflammation,                                                                                                     
          Membranoproliferative                        6 (12%)      1 (6%)       1 (7%)       3 (6%)                                
      Proximal Convoluted Renal Tubule,                                                                                             
          Degeneration, Hyaline                        1 (2%)                                 2 (4%)                                
      Proximal Convoluted Renal Tubule, Renal                                                                                       
          Tubule, Degeneration, Hyaline                             2 (12%)      1 (7%)                                             
      Proximal Convoluted Renal Tubule, Renal                                                                                       
          Tubule, Pigmentation                                                   1 (7%)                                             
      Renal Tubule, Dilatation                         1 (2%)                                 3 (6%)                                
      Renal Tubule, Hypertrophy                                     1 (6%)                                                          
      Renal Tubule, Mineralization                                  1 (6%)       1 (7%)                                             
      Renal Tubule, Pigmentation                                                 1 (7%)                                             
   Urinary Bladder                                    (47)         (15)         (12)         (46)                                   
      Polyarteritis                                                 2 (13%)                                                         
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  8            7            8            9                                     
  Early Deaths                                                                                                                      
    Dead                                              10           22            8            6                                     
    Moribund                                          12           14           17           15                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           17           27           30                                     
  Missing                                              1                                                                            
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (40)         (20)         (20)         (43)                                   
      Inflammation, Chronic Active                     2 (5%)                                                                       
      Epithelium, Cytoplasmic Alteration                                                      2 (5%)                                
      Wall, Mucocele                                                                          1 (2%)                                
   Intestine Large, Cecum                             (42)         (42)         (48)         (46)                                   
      Lymphoid Tissue, Hyperplasia, Lymphoid                        1 (2%)                                                          
      Lymphoid Tissue, Pigmentation                                                           1 (2%)                                
   Intestine Large, Colon                             (45)         (42)         (50)         (46)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Large, Rectum                            (44)         (41)         (50)         (46)                                   
      Inflammation, Acute                                           1 (2%)                                                          
   Intestine Small, Duodenum                          (43)         (36)         (46)         (45)                                   
      Lymphoid Tissue, Hyperplasia, Lymphoid                                                  1 (2%)                                
   Intestine Small, Ileum                             (42)         (39)         (47)         (45)                                   
      Inflammation, Acute                              1 (2%)                                                                       
      Lymphoid Tissue, Hyperplasia                                                            1 (2%)                                
      Lymphoid Tissue, Pigmentation                                              2 (4%)                                             
   Intestine Small, Jejunum                           (42)         (37)         (47)         (45)                                   
      Lymphoid Tissue, Hyperplasia                                               1 (2%)                                             
      Lymphoid Tissue, Hyperplasia, Lymphoid           2 (5%)       2 (5%)       7 (15%)      7 (16%)                               
      Lymphoid Tissue, Inflammation, Chronic           1 (2%)                    1 (2%)                                             
      Lymphoid Tissue, Pigmentation                                 4 (11%)     14 (30%)     10 (22%)                               
   Liver                                              (49)         (50)         (50)         (49)                                   
      Basophilic Focus                                 2 (4%)                                 1 (2%)                                
      Clear Cell Focus                                                           1 (2%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)       7 (14%)      2 (4%)       1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic                                         2 (4%)                    1 (2%)                                
      Hepatocyte, Necrosis                             3 (6%)       8 (16%)      6 (12%)      3 (6%)                                
      Hepatocyte, Vacuolization Cytoplasmic                                      1 (2%)                                             
      Serosa, Fibrosis                                                                        1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Sinusoid, Dilatation                             1 (2%)       1 (2%)                                                          
   Mesentery                                                                    (3)          (2)                                    
      Fat, Congestion                                                            1 (33%)                                            
      Fat, Necrosis                                                              2 (67%)                                            
   Pancreas                                           (49)         (31)         (25)         (47)                                   
      Inflammation, Chronic                                         1 (3%)       1 (4%)                                             
      Acinar Cell, Atrophy                             1 (2%)                                 1 (2%)                                
   Salivary Glands                                    (49)         (32)         (22)         (48)                                   
      Duct, Ectasia                                                                           1 (2%)                                
      Duct, Submandibular Gland, Hyperplasia           1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (48)         (50)         (48)                                   
      Hyperkeratosis                                                1 (2%)       3 (6%)       5 (10%)                               
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Inflammation, Acute                                                        1 (2%)       3 (6%)                                
      Ulcer                                                                      1 (2%)                                             
      Epithelium, Hyperplasia                                       1 (2%)       1 (2%)       7 (15%)                               
   Stomach, Glandular                                 (49)         (48)         (50)         (44)                                   
      Inflammation, Acute                                           1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                                      2 (4%)                                             
      Mineralization                                   9 (18%)      7 (15%)      4 (8%)       7 (16%)                               
      Ulcer, Focal                                     1 (2%)                                                                       
      Mucosa, Granuloma                                                                       1 (2%)                                
      Mucosa, Hyperplasia                              4 (8%)       2 (4%)                    3 (7%)                                
   Tooth                                              (3)          (3)          (1)          (4)                                    
      Incisor, Developmental Malformation              3 (100%)     3 (100%)     1 (100%)     3 (75%)                               
      Incisor, Inflammation, Chronic Active                                                   1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                       (1)                                                 
      Aorta, Inflammation, Chronic                     1 (100%)                                                                     
      Carotid Artery, Aneurysm                                                   1 (100%)                                           
   Heart                                              (49)         (32)         (23)         (50)                                   
      Inflammation, Acute                                           2 (6%)                    1 (2%)                                
      Inflammation, Chronic                            2 (4%)                                                                       
      Artery, Polyarteritis, Chronic                   1 (2%)                                                                       
      Atrioventricular Valve, Inflammation, Chronic                                           1 (2%)                                
      Atrium, Thrombosis                                            1 (3%)                                                          
      Endocardium, Inflammation, Acute                              1 (3%)                                                          
      Interstitium, Fibrosis                           7 (14%)      3 (9%)       2 (9%)       7 (14%)                               
      Myocardium, Degeneration                         1 (2%)       1 (3%)       2 (9%)       2 (4%)                                
      Myocardium, Mineralization                                    1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (32)         (23)         (48)                                   
      Clear Cell Focus                                 3 (6%)                                 1 (2%)                                
      Clear Cell Focus, Focal                                                                 1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Hematocyst                                                                              1 (2%)                                
      Hemorrhage, Focal                                                                       1 (2%)                                
      Hyperplasia, Focal                               1 (2%)                    1 (4%)       2 (4%)                                
      Hypertrophy, Focal                               8 (17%)      2 (6%)       4 (17%)      9 (19%)                               
      Necrosis                                                                   1 (4%)                                             
      Extra Adrenal Tissue, Accessory Adrenal                                                                                       
          Cortical Nodule                              1 (2%)                                 2 (4%)                                
      Spindle Cell, Hyperplasia                       41 (85%)     21 (66%)     15 (65%)     41 (85%)                               
      Unilateral, Atrophy                                                        1 (4%)                                             
   Adrenal Gland, Medulla                             (48)         (32)         (23)         (48)                                   
      Hyperplasia                                      2 (4%)       3 (9%)                    2 (4%)                                
      Hyperplasia, Focal                                                         1 (4%)                                             
      Unilateral, Necrosis                                                       1 (4%)                                             
   Islets, Pancreatic                                 (49)         (30)         (23)         (47)                                   
      Cyst                                                                                    1 (2%)                                
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (46)         (26)         (20)         (47)                                   
      Cyst                                             2 (4%)       2 (8%)       1 (5%)       1 (2%)                                
      Ectopic Thymus                                                                          1 (2%)                                
   Pituitary Gland                                    (41)         (29)         (22)         (48)                                   
      Pars Distalis, Congestion                                     1 (3%)                                                          
      Pars Distalis, Cyst                              1 (2%)       1 (3%)                    3 (6%)                                
      Pars Distalis, Hyperplasia                       1 (2%)                                 1 (2%)                                
   Thyroid Gland                                      (49)         (30)         (23)         (50)                                   
      Inflammation, Acute                                                        1 (4%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Ultimobranchial Cyst                             1 (2%)       1 (3%)                                                          
      Follicle, Cyst                                   4 (8%)                                 3 (6%)                                
      Follicular Cell, Hyperplasia                     2 (4%)       1 (3%)       1 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                                                         (1)                                    
      Lumen, Dilatation                                                                       1 (100%)                              
   Epididymis                                         (49)         (32)         (23)         (50)                                   
      Fibrosis                                         1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Granuloma Sperm                                                                         2 (4%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hypospermia                                      2 (4%)                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                    2 (9%)       1 (2%)                                
      Inflammation, Subacute                                                                  1 (2%)                                
      Spermatocele                                     1 (2%)                                                                       
      Unilateral, Necrosis                                                       1 (4%)                                             
   Penis                                              (1)          (1)          (1)                                                 
      Cyst                                                          1 (100%)                                                        
      Inflammation, Acute                              1 (100%)                  1 (100%)                                           
   Preputial Gland                                    (9)          (6)          (9)          (11)                                   
      Abscess                                          1 (11%)      1 (17%)      1 (11%)      1 (9%)                                
      Inflammation, Acute                                                                     3 (27%)                               
      Inflammation, Chronic                            6 (67%)      3 (50%)                   4 (36%)                               
      Duct, Ectasia                                    6 (67%)      4 (67%)      7 (78%)      8 (73%)                               
   Prostate                                           (48)         (32)         (23)         (48)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Acute                              2 (4%)       5 (16%)      1 (4%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)       2 (6%)       1 (4%)                                             
      Inflammation, Chronic Active                     2 (4%)                                                                       
   Seminal Vesicle                                    (49)         (32)         (25)         (48)                                   
      Depletion Cellular                               1 (2%)       1 (3%)       1 (4%)                                             
      Inflammation, Acute                                           2 (6%)       1 (4%)                                             
      Inflammation, Chronic                            2 (4%)       2 (6%)       1 (4%)       1 (2%)                                
      Lumen, Dilatation                                                                       1 (2%)                                
   Testes                                             (49)         (32)         (23)         (49)                                   
      Polyarteritis, Chronic                           1 (2%)                    1 (4%)                                             
      Interstitial Cell, Hyperplasia                   1 (2%)                                                                       
      Interstitium, Pigmentation                                                              1 (2%)                                
      Seminiferous Tubule, Atrophy                     4 (8%)                    2 (9%)       4 (8%)                                
      Seminiferous Tubule, Degeneration                1 (2%)                                                                       
      Seminiferous Tubule, Dilatation                                                         1 (2%)                                
      Seminiferous Tubule, Giant Cell                  3 (6%)                    1 (4%)       1 (2%)                                
      Seminiferous Tubule, Mineralization                                                     1 (2%)                                
      Unilateral, Necrosis                                                       1 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (31)         (22)         (48)                                   
      Erythroid Cell, Hyperplasia                                                             3 (6%)                                
      Myeloid Cell, Hyperplasia                       13 (27%)      1 (3%)       2 (9%)      12 (25%)                               
   Lymph Node                                         (49)         (50)         (49)         (48)                                   
      Iliac, Hyperplasia, Lymphoid                     1 (2%)                                                                       
      Iliac, Hyperplasia, Plasma Cell                                            1 (2%)                                             
      Inguinal, Autolysis                                           1 (2%)                                                          
      Inguinal, Hematopoietic Cell Proliferation                    1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inguinal, Hyperplasia, Lymphoid                  3 (6%)                                                                       
      Inguinal, Hyperplasia, Plasma Cell               1 (2%)       2 (4%)                                                          
      Inguinal, Lymphocyte, Necrosis                                2 (4%)       2 (4%)                                             
      Mesenteric, Angiectasis                         10 (20%)      8 (16%)      9 (18%)     13 (27%)                               
      Mesenteric, Autolysis                                         2 (4%)                                                          
      Mesenteric, Congestion                                                     1 (2%)       1 (2%)                                
      Mesenteric, Hematopoietic Cell Proliferation    14 (29%)     10 (20%)      8 (16%)      9 (19%)                               
      Mesenteric, Hyperplasia, Lymphoid               16 (33%)     10 (20%)     16 (33%)     22 (46%)                               
      Mesenteric, Inflammation, Acute                  4 (8%)       4 (8%)       1 (2%)       6 (13%)                               
      Mesenteric, Inflammation, Chronic                                          1 (2%)                                             
      Mesenteric, Pigmentation                                      8 (16%)     14 (29%)     16 (33%)                               
      Mesenteric, Thrombosis                           1 (2%)       2 (4%)                                                          
      Mesenteric, Lymphocyte, Necrosis                 2 (4%)       2 (4%)       3 (6%)                                             
      Renal, Lymphocyte, Hyperplasia                                1 (2%)                                                          
      Renal, Lymphocyte, Necrosis                                   1 (2%)                                                          
   Lymph Node, Mandibular                             (48)         (27)         (21)         (48)                                   
      Hyperplasia, Lymphoid                                         1 (4%)       1 (5%)       2 (4%)                                
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
      Hyperplasia, Re Cell                             1 (2%)                                                                       
      Pigmentation                                                               1 (5%)                                             
      Lymphocyte, Necrosis                                                       1 (5%)                                             
   Spleen                                             (49)         (31)         (26)         (47)                                   
      Angiectasis                                                   1 (3%)       1 (4%)                                             
      Hematopoietic Cell Proliferation                20 (41%)     15 (48%)     13 (50%)     16 (34%)                               
      Hyperplasia, Lymphoid                            5 (10%)      2 (6%)       3 (12%)      6 (13%)                               
      Hyperplasia, Re Cell                             1 (2%)                                                                       
      Capsule, Inflammation, Chronic                                                          1 (2%)                                
      Lymphocyte, Depletion Cellular                                1 (3%)                                                          
      Lymphocyte, Necrosis                             2 (4%)       3 (10%)      2 (8%)       1 (2%)                                
      Red Pulp, Depletion Cellular                                  1 (3%)                                                          
   Thymus                                             (39)         (18)         (14)         (32)                                   
      Atrophy                                          7 (18%)     10 (56%)      3 (21%)      7 (22%)                               
      Cyst                                            12 (31%)      2 (11%)      3 (21%)     13 (41%)                               
      Inflammation, Acute                              1 (3%)                                                                       
      Cortex, Necrosis                                 4 (10%)      2 (11%)                   3 (9%)                                
      Medulla, Atrophy                                                                        1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                                                             (1)                                    
      Acinus, Duct, Dilatation                                                                1 (100%)                              
   Skin                                               (49)         (50)         (48)         (50)                                   
      Parakeratosis                                    1 (2%)                                                                       
      Ulcer                                            4 (8%)       4 (8%)       3 (6%)       2 (4%)                                
      Dermis, Fibrosis                                 1 (2%)                                 4 (8%)                                
      Dermis, Inflammation, Acute                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Dermis, Inflammation, Chronic                   19 (39%)     16 (32%)     13 (27%)     12 (24%)                               
      Dermis, Mineralization                                        1 (2%)                    2 (4%)                                
      Epidermis, Hyperkeratosis                                                               1 (2%)                                
      Epithelium, Hyperplasia                          3 (6%)                    2 (4%)       3 (6%)                                
      Prepuce, Inflammation, Chronic                   1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (32)         (23)         (50)                                   
      Joint, Arthrosis                                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (32)         (23)         (49)                                   
      Perivascular, Fibrosis, Focal                                                           1 (2%)                                
      Thalamus, Mineralization                        39 (78%)     14 (44%)      9 (39%)     34 (69%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (49)         (50)         (50)                                   
      Congestion                                       2 (4%)       3 (6%)       3 (6%)       2 (4%)                                
      Hemorrhage                                       2 (4%)                                 2 (4%)                                
      Inflammation, Acute                              2 (4%)       2 (4%)                                                          
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)                    1 (2%)                                
      Peribronchial, Glands, Exudate                   1 (2%)                                                                       
      Peribronchiolar, Cyst                                                      1 (2%)                                             
      Perivascular, Inflammation, Chronic              1 (2%)                                                                       
      Pleura, Fibrosis                                 1 (2%)                                                                       
      Pleura, Inflammation, Chronic                                              1 (2%)                                             
   Nose                                               (49)         (32)         (23)         (49)                                   
      Exudate, Purulent                                3 (6%)                    1 (4%)       1 (2%)                                
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Acute                              2 (4%)                                 1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Lumen, Hemorrhage                                1 (2%)                                                                       
      Nasolacrimal Duct, Exudate                                                              1 (2%)                                
      Nasolacrimal Duct, Foreign Body                  1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                                                                       
      Submucosa, Cyst                                  1 (2%)                                                                       
      Vomeronasal Organ, Exudate, Purulent             1 (2%)                                                                       
      Vomeronasal Organ, Foreign Body                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                    (1)                                    
      Phthisis Bulbi                                   1 (100%)                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (33)         (23)         (50)                                   
      Cyst                                             2 (4%)       1 (3%)                                                          
      Infarct, Chronic                                 1 (2%)       2 (6%)       3 (13%)                                            
      Inflammation, Acute                              1 (2%)                                                                       
      Nephropathy                                     37 (76%)     12 (36%)     12 (52%)     37 (74%)                               
      Artery, Polyarteritis, Chronic                   1 (2%)                                                                       
      Cortex, Metaplasia, Osseous                                                1 (4%)       1 (2%)                                
      Cortex, Renal Tubule, Necrosis, Acute            1 (2%)                                                                       
      Medulla, Congestion                              1 (2%)       1 (3%)       2 (9%)                                             
      Papilla, Necrosis                                             1 (3%)                                                          
      Pelvis, Inflammation, Acute                      1 (2%)       2 (6%)                                                          
      Proximal Convoluted Renal Tubule,                                                                                             
          Degeneration, Hyaline                        1 (2%)                                                                       
      Renal Tubule, Dilatation                         2 (4%)       2 (6%)       1 (4%)       5 (10%)                               
      Renal Tubule, Hypertrophy                        1 (2%)       1 (3%)                    1 (2%)                                
      Renal Tubule, Mineralization                    11 (22%)      3 (9%)       1 (4%)      10 (20%)                               
   Urethra                                            (4)          (1)          (1)          (1)                                    
      Calculus Micro Observation Only                               1 (100%)                                                        
      Inflammation, Acute                              3 (75%)                                1 (100%)                              
      Bulbourethral Gland, Ectasia                     1 (25%)                   1 (100%)                                           
      Bulbourethral Gland, Inflammation, Acute         1 (25%)                                1 (100%)                              
   Urinary Bladder                                    (44)         (28)         (22)         (46)                                   
      Inflammation, Acute                                           1 (4%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (4%)       1 (5%)       1 (2%)                                
      Transitional Epithelium, Hyperplasia                          2 (7%)       1 (5%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.