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TDMS Study 05021-04 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         CI PIGMENT RED 23


NTP Experiment-Test: 05021-04                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: DOSED FEED                                                                                                 Time: 23:04:55




       Facility:  Southern Research Institute

       Chemical CAS #:  6471-49-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05021-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          11            7           11           10                                     
    Dead                                               4            8            3            4                                     
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           34           36           35                                     
  Missing                                                                                     1                                     
  Animals Examined Microscopically                    50           50           50           49                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (15)         (14)         (48)                                   
   Gallbladder                                        (46)         (12)         (12)         (46)                                   
   Intestine Large, Cecum                             (47)         (47)         (48)         (46)                                   
      Leiomyoma                                                     1 (2%)                                                          
   Intestine Large, Colon                             (47)         (47)         (48)         (46)                                   
   Intestine Large, Rectum                            (46)         (48)         (48)         (46)                                   
   Intestine Small, Duodenum                          (46)         (46)         (47)         (46)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Intestine Small, Ileum                             (46)         (45)         (48)         (46)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Intestine Small, Jejunum                           (46)         (46)         (48)         (47)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Liver                                              (49)         (49)         (50)         (48)                                   
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                       1 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma                         3 (6%)       4 (8%)       5 (10%)      2 (4%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)                                 1 (2%)                                
      Hepatocellular Adenoma                           1 (2%)       5 (10%)      4 (8%)       1 (2%)                                
      Hepatocellular Adenoma, Multiple                                           1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Plasma Cell Tumor Malignant                                   1 (2%)                                                          
   Mesentery                                          (7)                       (4)          (3)                                    
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                                       1 (33%)                               
   Pancreas                                           (49)         (14)         (15)         (47)                                   
      Histiocytic Sarcoma                                                        1 (7%)                                             
      Plasma Cell Tumor Malignant                                   1 (7%)                                                          
   Salivary Glands                                    (49)         (16)         (14)         (49)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 05021-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Forestomach                               (49)         (49)         (50)         (49)                                   
      Plasma Cell Tumor Malignant                                   1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)                    1 (2%)                                
   Stomach, Glandular                                 (48)         (48)         (50)         (45)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (16)         (14)         (49)                                   
      Histiocytic Sarcoma                                                        1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (15)         (14)         (48)                                   
   Adrenal Gland, Cortex                              (49)         (15)         (14)         (48)                                   
      Adenoma                                                       1 (7%)                    1 (2%)                                
   Adrenal Gland, Medulla                             (49)         (15)         (14)         (47)                                   
      Pheochromocytoma Malignant                                                              1 (2%)                                
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (15)         (15)         (47)                                   
      Adenoma                                          1 (2%)       1 (7%)       1 (7%)                                             
   Pituitary Gland                                    (50)         (23)         (16)         (47)                                   
      Pars Distalis, Adenoma                          16 (32%)      7 (30%)      6 (38%)     11 (23%)                               
      Pars Distalis, Carcinoma                         2 (4%)                    1 (6%)       2 (4%)                                
   Thyroid Gland                                      (50)         (15)         (14)         (49)                                   
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                       1 (2%)                                                                       
      Follicular Cell, Adenoma                         2 (4%)       1 (7%)                    3 (6%)                                
      Follicular Cell, Adenoma, Minimal                                          1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (47)         (20)         (28)         (48)                                   
      Cystadenocarcinoma                                                                      1 (2%)                                
      Cystadenoma                                                   1 (5%)                                                          
      Granulosa-Theca Tumor Benign                                  1 (5%)                                                          
      Histiocytic Sarcoma                              1 (2%)                    1 (4%)                                             
      Luteoma                                                                                 1 (2%)                                
      Mixed Tumor Malignant                                                                   1 (2%)                                
      Plasma Cell Tumor Malignant                                   1 (5%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05021-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Bilateral, Granulosa Cell Tumor Malignant        1 (2%)                                                                       
      Bilateral, Granulosa Cell Tumor Benign           1 (2%)                                                                       
   Uterus                                             (49)         (41)         (39)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leiomyoma                                                                  1 (3%)                                             
      Leiomyosarcoma                                                                          1 (2%)                                
      Polyp Stromal                                    1 (2%)       4 (10%)                   4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (49)         (49)                                   
      Hemangiosarcoma                                                            2 (4%)       2 (4%)                                
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
   Lymph Node                                         (50)         (48)         (50)         (49)                                   
      Iliac, Histiocytic Sarcoma                       1 (2%)                                                                       
      Inguinal, Sarcoma, Metastatic, Skin                           1 (2%)                                                          
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)                                                          
      Mediastinal, Histiocytic Sarcoma                 1 (2%)                                 1 (2%)                                
      Mediastinal, Pheochromocytoma Malignant,                                                                                      
           Metastatic, Adrenal Gland                                                          1 (2%)                                
      Mediastinal, Plasma Cell Tumor Malignant                      1 (2%)                                                          
      Mesenteric, Histiocytic Sarcoma                  2 (4%)                                                                       
      Mesenteric, Plasma Cell Tumor Malignant                       1 (2%)                                                          
      Mesenteric, Sarcoma, Metastatic, Skin                         1 (2%)                                                          
      Renal, Hemangiosarcoma                                        1 (2%)                                                          
      Renal, Histiocytic Sarcoma                       1 (2%)                                                                       
      Renal, Plasma Cell Tumor Malignant                            1 (2%)                                                          
      Renal, Sarcoma, Metastatic, Skin                              1 (2%)                                                          
   Lymph Node, Mandibular                             (49)         (18)         (15)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Plasma Cell Tumor Malignant                                   1 (6%)                                                          
   Spleen                                             (50)         (21)         (25)         (48)                                   
      Hemangiosarcoma                                                            2 (8%)                                             
      Histiocytic Sarcoma                              1 (2%)                    1 (4%)       1 (2%)                                
      Plasma Cell Tumor Malignant                                   1 (5%)                                                          
   Thymus                                             (18)         (7)          (14)         (39)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (15)         (15)         (48)                                   
      Adenocarcinoma                                   1 (2%)       1 (7%)                                                          
   Skin                                               (49)         (48)         (48)         (49)                                   
      Fibrosarcoma                                     1 (2%)                                 1 (2%)                                
      Hemangiosarcoma                                                            1 (2%)                                             
                                                             Page   4                                                               
NTP Experiment-Test: 05021-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Sarcoma                                                       2 (4%)                    1 (2%)                                
      Schwannoma Malignant                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (16)         (14)         (49)                                   
      Pelvis, Osteosarcoma                                          1 (6%)                                                          
      Vertebra, Granulosa Cell Tumor Malignant,                                                                                     
           Metastatic, Ovary                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (15)         (14)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (49)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       2 (4%)       4 (8%)                                
      Alveolar/Bronchiolar Carcinoma                                                          1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                                       1 (2%)                                
      Plasma Cell Tumor Malignant                                   1 (2%)                                                          
      Sarcoma, Metastatic, Skin                                     2 (4%)                    1 (2%)                                
   Nose                                               (50)         (15)         (14)         (49)                                   
      Vomeronasal Organ, Histiocytic Sarcoma                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (2)          (4)                                                 
      Adenoma                                                       2 (100%)     3 (75%)                                            
      Carcinoma                                                                  1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (17)         (15)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (7%)       1 (2%)                                
      Plasma Cell Tumor Malignant                                   1 (6%)                                                          
   Urinary Bladder                                    (47)         (15)         (12)         (46)                                   
                                                             Page   5                                                               
NTP Experiment-Test: 05021-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(49)                                   
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Lymphoma Malignant                               1 (2%)                                                                       
      Lymphoma Malignant Lymphocytic                                2 (4%)                    2 (4%)                                
      Lymphoma Malignant Mixed                         5 (10%)      4 (8%)       8 (16%)      7 (14%)                               
      Lymphoma Malignant Undifferentiated Cell                      3 (6%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05021-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            27          31          31          32                                       
     Total Primary Neoplasms                           41          58          42          51                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 19          19          17          18                                       
     Total Benign Neoplasms                            24          26          19          26                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          20          21          18                                       
     Total Malignant Neoplasms                         17          32          23          25                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4           1           2                                       
     Total Metastatic Neoplasm                          3           7           1           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05021-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  8            7            8            9                                     
  Early Deaths                                                                                                                      
    Dead                                              10           22            8            6                                     
    Moribund                                          12           14           17           15                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           17           27           30                                     
  Missing                                              1                                                                            
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (43)         (36)         (46)         (45)                                   
      Polyp                                                         1 (3%)                                                          
   Intestine Small, Jejunum                           (42)         (37)         (47)         (45)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
      Lymphoid Tissue, Histiocytic Sarcoma                          2 (5%)                                                          
   Liver                                              (49)         (50)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hemangiosarcoma                                                            4 (8%)                                             
      Hepatocellular Carcinoma                         9 (18%)      6 (12%)      9 (18%)     11 (22%)                               
      Hepatocellular Carcinoma, Multiple               3 (6%)       1 (2%)       1 (2%)       4 (8%)                                
      Hepatocellular Adenoma                           2 (4%)       1 (2%)       3 (6%)       6 (12%)                               
      Hepatocellular Adenoma, Multiple                 1 (2%)                    1 (2%)       2 (4%)                                
      Histiocytic Sarcoma                                           2 (4%)       2 (4%)                                             
   Mesentery                                                                    (3)          (2)                                    
   Pancreas                                           (49)         (31)         (25)         (47)                                   
   Salivary Glands                                    (49)         (32)         (22)         (48)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
   Stomach, Forestomach                               (49)         (48)         (50)         (48)                                   
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (49)         (48)         (50)         (44)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05021-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (48)         (32)         (23)         (48)                                   
   Adrenal Gland, Cortex                              (48)         (32)         (23)         (48)                                   
      Adenoma                                          2 (4%)                                 3 (6%)                                
      Histiocytic Sarcoma                                           1 (3%)                                                          
   Adrenal Gland, Medulla                             (48)         (32)         (23)         (48)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                                                                 1 (2%)                                
   Pituitary Gland                                    (41)         (29)         (22)         (48)                                   
      Pars Distalis, Adenoma                                                                  2 (4%)                                
   Thyroid Gland                                      (49)         (30)         (23)         (50)                                   
      Follicular Cell, Adenoma                         2 (4%)       2 (7%)                    2 (4%)                                
      Follicular Cell, Carcinoma                       1 (2%)                    1 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)          (2)                                                 
      Mediastinum, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Seminal Vesicle                                    (49)         (32)         (25)         (48)                                   
      Histiocytic Sarcoma                                                        1 (4%)                                             
   Testes                                             (49)         (32)         (23)         (49)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Interstitial Cell, Adenoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (31)         (22)         (48)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                    2 (9%)                                             
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
   Lymph Node                                         (49)         (50)         (49)         (48)                                   
      Axillary, Sarcoma, Metastatic, Skin                           1 (2%)                                                          
      Inguinal, Sarcoma, Metastatic, Skin              1 (2%)                                                                       
      Mesenteric, Histiocytic Sarcoma                               2 (4%)       2 (4%)                                             
      Pancreatic, Histiocytic Sarcoma                                            1 (2%)                                             
   Lymph Node, Mandibular                             (48)         (27)         (21)         (48)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05021-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (49)         (31)         (26)         (47)                                   
      Hemangiosarcoma                                  1 (2%)       1 (3%)       1 (4%)                                             
      Histiocytic Sarcoma                                           2 (6%)       1 (4%)                                             
   Thymus                                             (39)         (18)         (14)         (32)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (50)         (48)         (50)                                   
      Fibroma                                          4 (8%)       1 (2%)       2 (4%)       1 (2%)                                
      Fibroma, Multiple                                                                       1 (2%)                                
      Fibrosarcoma                                     3 (6%)       5 (10%)      5 (10%)      4 (8%)                                
      Fibrosarcoma, Multiple                           2 (4%)                                 1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Sarcoma                                          5 (10%)      7 (14%)      5 (10%)      5 (10%)                               
      Sarcoma, Multiple                                                                       1 (2%)                                
      Schwannoma Malignant                                                       1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (32)         (23)         (49)                                   
      Third Ventricle, Lipoma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (49)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)       5 (10%)      6 (12%)      2 (4%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                    2 (4%)       4 (8%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       1 (2%)       2 (4%)       3 (6%)                                
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Nose                                               (49)         (32)         (23)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05021-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (1)          (1)          (1)                                    
      Adenoma                                          2 (100%)     1 (100%)     1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (33)         (23)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (3%)       1 (4%)                                             
      Bilateral, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                            1 (2%)                                                                       
      Cortex, Renal Tubule, Adenoma                                                           1 (2%)                                
      Renal Tubule, Adenoma                                         1 (3%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           3 (6%)       2 (4%)                                             
      Leukemia Granulocytic                            1 (2%)                                                                       
      Lymphoma Malignant                                                                      1 (2%)                                
      Lymphoma Malignant Mixed                         2 (4%)                    1 (2%)       3 (6%)                                
      Lymphoma Malignant Undifferentiated Cell                                                2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05021-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 23:04:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          27          33          41                                       
     Total Primary Neoplasms                           54          37          48          63                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 17          13          12          20                                       
     Total Benign Neoplasms                            18          13          14          26                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          22          28          31                                       
     Total Malignant Neoplasms                         36          24          34          37                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           3           3           4                                       
     Total Metastatic Neoplasm                          9           3           4           5                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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