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TDMS Study 05021-04 Pathology Tables

NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97
Route: DOSED FEED                                                                                                 Time: 11:50:29




       Facility:  Southern Research Institute

       Chemical CAS #:  6471-49-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 9| 5| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 3| 3| 3| 4| 5| 3| 3| 3| 4| 4| 3| 4| 7| 4| 4| 4| 0| 4| 5| 5| 5| 5| 5| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Wall, Mucocele                       |                                        1  1                              |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                1                                                  2  2   |             
      Submucosa, Edema                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                          2               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                            1                                             |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                2                                                         |             
      Hematopoietic Cell Proliferation     |       1                                                  2        2      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                2                    2           3        2               |             
      Hepatocyte, Cytomegaly, Focal        |                                  2                                2      |             
      Hepatocyte, Necrosis                 |                                     2           1                        |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                 2                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                         2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                     1                                    |             
      Acinar Cell, Atrophy                 |       4                                                        4         |             
      Duct, Ectasia                        |    2  3                                                        3         |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                      1   |             
      Angiectasis                          |                                                 2                        |             
      Hyperkeratosis                       |                                                                      1   |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                               1                                      1   |             
      Epithelium, Hyperplasia, Multiple    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 9| 5| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 3| 3| 3| 4| 5| 3| 3| 3| 4| 4| 3| 4| 7| 4| 4| 4| 0| 4| 5| 5| 5| 5| 5| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                1                                                         |             
      Mineralization                       |    2        2                    2                                      2|             
      Mucosa, Hyperplasia                  |                   2  1                                                   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
      Incisor, Abscess                     |                                                                   2      |             
      Incisor, Developmental Malformation  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                 +                        |             
      Pulmonary Artery, Inflammation, Acute|                                                 2                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                     1           2        1               |             
      Atrioventricular Valve, Thrombosis   |                                                                          |             
      Epicardium, Fibrosis                 |                                                                          |             
      Interstitium, Fibrosis               |          1  1                                         1                  |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Hypertrophy, Focal                   |                                                                      2   |             
      Inflammation, Acute                  |                                                 2                        |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     | 1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Extra Adrenal Tissue, Accessory      |                                                                          |             
          Adrenal Cortical Nodule          |                                                                          |             
      Spindle Cell, Hyperplasia            | 3  3  2     3  3  3  3  2  2  2  2  3  2  2  2  2  3  2  3  3  3  3  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2     2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  2     2                                 |             
      Ectopic Thymus                       |                                                    1                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                     2                                    |             
      Pars Distalis, Degeneration, Cystic  |                                                 1                        |             
      Pars Distalis, Hyperplasia           | 2              3           3                                            2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |       1                 1                                                |             
      Follicle, Cyst                       |                   2                                   1                  |             
      Follicular Cell, Hyperplasia         |                   2  2                                1                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 9| 5| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 3| 3| 3| 4| 5| 3| 3| 3| 4| 4| 3| 4| 7| 4| 4| 4| 0| 4| 5| 5| 5| 5| 5| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                   4                 4           4        4               |             
      Atrophy                              |       3     3  2  2  2  2  2  2        3  2  2        2  3     2     2  2|             
      Cyst                                 | 1                                                                        |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |             1                                                            |             
      Pigmentation, Ceroid                 |       3     3  3  3  3  3  3  3  2  3  3  3  3        2  2  3  3  3  3  2|             
      Follicle, Cyst                       |                               3        2           4           3     2   |             
      Follicle, Hemorrhage                 |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Acute                           |                                        2                                 |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |       3                                                           3      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Exudate, Purulent                    |                                     2  3        2        2               |             
      Hemorrhage                           |                            2                                             |             
      Hydrometra                           |                   3                                                      |             
      Endometrium, Hyperplasia, Cystic     | 2     3     3  3  2  3  3  2  2  2  1  1  2  2     2  3  2  2  3  2  2  2|             
      Endometrium, Inflammation, Acute     |                               2                                          |             
      Endometrium, Inflammation, Chronic   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypocellularity                      |                            2     1                                      2|             
      Myelofibrosis                        |       1        2  2  1  1     1        1        1     1        1     2   |             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            |       2           4                 2  3  1     3        3               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Iliac, Inflammation, Chronic         |                                     3                                    |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Inflammation, Acute     |                                                                          |             
      Mediastinal, Inflammation, Chronic   |                                                 3        2               |             
      Mesenteric, Angiectasis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 9| 5| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 3| 3| 3| 4| 5| 3| 3| 3| 4| 4| 3| 4| 7| 4| 4| 4| 0| 4| 5| 5| 5| 5| 5| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Autolysis                |          4                                                               |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                  1     3                          2  1   |             
      Mesenteric, Hyperplasia, Plasma Cell |                                                 3                        |             
      Mesenteric, Inflammation, Acute      |                                                 2                        |             
      Mesenteric, Inflammation, Chronic    |                                     2                    1               |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
      Renal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                2                                                  2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       2           3        2        3  1  3     4  3  2  3  3            |             
      Hyperplasia, Lymphoid                |                                  1                                2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  A  M  M  +  +  M  M  M  +  M  M  M  M  +  M  +  M  +  M  M  M|             
      Atrophy                              |                                                                          |             
      Cyst                                 |    1                 2                                                   |             
      Cortex, Necrosis                     |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              2                           |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Fibrosis                     |                                        2                                 |             
      Dermis, Inflammation, Acute          |                                                                          |             
      Dermis, Inflammation, Chronic        | 1  1        2  1     1  1  1     1     1        2        2        1      |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Compression              |          3                                                               |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                   3      |             
      Thalamus, Mineralization             |    2  1  1     2  2     2  1  1  2  2  2  2  2  2  2  1  1     1     2  2|             
      Third Ventricle, Infiltration        |                                                                          |             
          Cellular, Lipocyte               |    2                                                                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
      Nerve, Demyelination                 |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 9| 5| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 3| 3| 3| 4| 5| 3| 3| 3| 4| 4| 3| 4| 7| 4| 4| 4| 0| 4| 5| 5| 5| 5| 5| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                      2   |             
      Inflammation, Acute                  |                                                                          |             
      Pleura, Inflammation, Acute          |                                                 2                        |             
      Pleura, Inflammation, Chronic        |                                                          2     2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Exudate, Purulent |                                                             1            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        | 2                          1                 1  2  1     2               |             
      Infarct, Chronic                     |                      2                                                   |             
      Nephropathy                          |    2           2  1     2        2     1              2     1        1  1|             
      Cortex, Metaplasia, Osseous          |                   1                                                      |             
      Corticomedullary Junction, Embolus   |                                                                          |             
          Bacterial, Focal                 |                                                                          |             
      Glomerulus, Inflammation,            |                                                                          |             
          Membranoproliferative            |                                     3           4        3               |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Degeneration, Hyaline           |                                                                          |             
      Renal Tubule, Dilatation             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 2| 2| 1| 5| 2| 1| 2| 2| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 1| 3|             
                                           | 5| 8| 8| 6| 9| 8| 8| 9| 9| 9| 9| 5| 9| 0| 0| 0| 0| 0| 0| 1| 1| 0| 0| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Wall, Mucocele                       |       1                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
      Submucosa, Edema                     |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                           2                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     | 3     1  3                                                  2     2  4   |             
      Inflammation, Acute                  |                      1                       1                           |             
      Inflammation, Chronic                |                                                                          |             
      Hepatocyte, Cytomegaly, Focal        |                                                                          |             
      Hepatocyte, Necrosis                 |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|             2                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +  +                          +                    +        +   |             
      Inflammation, Acute                  |          3                                                           3   |             
      Inflammation, Chronic                | 3                                                           3            |             
      Fat, Necrosis                        |             2                          2                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 2        2                                                               |             
      Acinar Cell, Atrophy                 |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
      Perivascular, Inflammation, Chronic  |                         3                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                1                       1     2                           |             
      Angiectasis                          |                                                                          |             
      Hyperkeratosis                       |                                              2                           |             
      Ulcer                                |                1                       1                                 |             
      Epithelium, Hyperplasia              |                                        2     2                           |             
      Epithelium, Hyperplasia, Multiple    |                2           2                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 2| 2| 1| 5| 2| 1| 2| 2| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 1| 3|             
                                           | 5| 8| 8| 6| 9| 8| 8| 9| 9| 9| 9| 5| 9| 0| 0| 0| 0| 0| 0| 1| 1| 0| 0| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       | 2  1                             3     2                             1   |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
      Incisor, Abscess                     |                                                                          |             
      Incisor, Developmental Malformation  |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Pulmonary Artery, Inflammation, Acute|                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |          3                                                               |             
      Inflammation, Chronic                | 1                                                                        |             
      Atrioventricular Valve, Thrombosis   |                                                             2            |             
      Epicardium, Fibrosis                 |                                                                   2      |             
      Interstitium, Fibrosis               |                   1                                                      |             
      Myocardium, Mineralization           |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                      4   |             
      Hypertrophy, Focal                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     | 1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1     1  1     1|             
      Extra Adrenal Tissue, Accessory      |                                                                          |             
          Adrenal Cortical Nodule          | X                                                                        |             
      Spindle Cell, Hyperplasia            | 3  3  3  3  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3                                                                 2   |             
      Ectopic Thymus                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                           3                              |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Degeneration, Cystic  |                                                                      2   |             
      Pars Distalis, Hyperplasia           |    2                                   2     2        2  1        1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Follicle, Cyst                       | 1        2           1                                                   |             
      Follicular Cell, Hyperplasia         |    1                          1        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 2| 2| 1| 5| 2| 1| 2| 2| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 1| 3|             
                                           | 5| 8| 8| 6| 9| 8| 8| 9| 9| 9| 9| 5| 9| 0| 0| 0| 0| 0| 0| 1| 1| 0| 0| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Abscess                              | 4        4                                                  4        4   |             
      Atrophy                              |    2  3                                2  2        2  2        2  2      |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                                       1                  |             
      Mineralization                       |                                                                          |             
      Pigmentation, Ceroid                 |    2  3     2  2        2     2     3  3  3  2     2  2        2  2  2   |             
      Follicle, Cyst                       |             2  3     3     3                    3                    3   |             
      Follicle, Hemorrhage                 |                                                                      3   |             
      Periovarian Tissue, Cyst             |                                                                   3      |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Acute                           |                                                                   2      |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              | 2                                                                        |             
      Exudate, Purulent                    |             2                          1                                 |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                      2                          2  3     2               |             
      Endometrium, Hyperplasia, Cystic     | 1  1  2     2  2  1  1  3  4     2  2  3  3  3     2  3  1     3  2      |             
      Endometrium, Inflammation, Acute     |          2                                                               |             
      Endometrium, Inflammation, Chronic   |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypocellularity                      |    1                                                                     |             
      Myelofibrosis                        |                1     1     1     2  2  1     1        1  2        2      |             
      Erythroid Cell, Hyperplasia          |                                                 2                        |             
      Myeloid Cell, Hyperplasia            | 3        3        2                                         3     2  4   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             2            |             
      Hyperplasia, Plasma Cell             |                                                             3            |             
      Iliac, Hyperplasia, Plasma Cell      | 3                                                                        |             
      Iliac, Inflammation, Chronic         |                                                                          |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                      3   |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                             2            |             
      Mediastinal, Hyperplasia, Plasma Cell| 3        3                                                  3            |             
      Mediastinal, Inflammation, Acute     |                                                                      2   |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
      Mesenteric, Angiectasis              |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 2| 2| 1| 5| 2| 1| 2| 2| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 1| 3|             
                                           | 5| 8| 8| 6| 9| 8| 8| 9| 9| 9| 9| 5| 9| 0| 0| 0| 0| 0| 0| 1| 1| 0| 0| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Autolysis                |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                      3   |             
      Mesenteric, Hyperplasia, Lymphoid    |       1                    1  1  4           1     2        3            |             
      Mesenteric, Hyperplasia, Plasma Cell |                                                             2            |             
      Mesenteric, Inflammation, Acute      |                                                    2                 2   |             
      Mesenteric, Inflammation, Chronic    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                            3                                             |             
      Renal, Hyperplasia, Plasma Cell      | 3        3                                                               |             
      Renal, Inflammation, Acute           |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
      Hyperplasia, Lymphoid                |                               3        3                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4     2  3     1  3     1  1  1                 3           4        4  4|             
      Hyperplasia, Lymphoid                |    1  2                                      1        2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  M  A  +  +  +  +  +  M  M  M  +  +  M  M  M  M  M  +  M  +  M  M|             
      Atrophy                              |                   3                                                      |             
      Cyst                                 |                   2                                                      |             
      Cortex, Necrosis                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                      2   |             
      Duct, Dilatation                     |                                                                2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Fibrosis                     |                                                                          |             
      Dermis, Inflammation, Acute          |          2                                   2                           |             
      Dermis, Inflammation, Chronic        |       2        1     2  2        1  1  1  2           1  2     2     2  2|             
      Subcutaneous Tissue, Edema           |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Compression              |                                                                          |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Thalamus, Mineralization             | 2  1  2  2  1  1  1  2  2  2  1  2  2  1  2  2  1  2  1  2     1  2  2  2|             
      Third Ventricle, Infiltration        |                                                                          |             
          Cellular, Lipocyte               |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Nerve, Demyelination                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 2| 2| 1| 5| 2| 1| 2| 2| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 1| 3|             
                                           | 5| 8| 8| 6| 9| 8| 8| 9| 9| 9| 9| 5| 9| 0| 0| 0| 0| 0| 0| 1| 1| 0| 0| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Acute                  |          3        2                                                      |             
      Pleura, Inflammation, Acute          |                                                                          |             
      Pleura, Inflammation, Chronic        |                2                                   1                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Exudate, Purulent |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Phthisis Bulbi                       |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                   2                                                      |             
      Infarct, Chronic                     |                                                 2  2                     |             
      Nephropathy                          |    1  1     2  3                    2  2  1        1  1  1     2  1  1  2|             
      Cortex, Metaplasia, Osseous          |                               1                                          |             
      Corticomedullary Junction, Embolus   |                                                                          |             
          Bacterial, Focal                 |          2                                                               |             
      Glomerulus, Inflammation,            |                                                                          |             
          Membranoproliferative            | 2                                                           2        2   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Degeneration, Hyaline           |                                                                         3|             
      Renal Tubule, Dilatation             |                            3                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 6| 5| 6| 6| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  46        |
      Wall, Mucocele                       |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  47        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      3  1.7|
      Submucosa, Edema                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  46        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  46        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  49        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      9  2.2|
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Inflammation, Chronic                |                                                                          |      4  2.3|
      Hepatocyte, Cytomegaly, Focal        |                                                                          |      2  2.0|
      Hepatocyte, Necrosis                 |                                                                          |      2  1.5|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Fat, Necrosis                        |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  49        |
      Inflammation, Acute                  |                                                                          |      3  1.7|
      Acinar Cell, Atrophy                 |                                                                          |      2  4.0|
      Duct, Ectasia                        |                                                                          |      3  2.7|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Abscess                              |                                                                          |      4  1.3|
      Angiectasis                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 6| 5| 6| 6| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |                                                                          |      2  1.5|
      Ulcer                                |                                                                          |      2  1.0|
      Epithelium, Hyperplasia              |                                                                          |      4  1.5|
      Epithelium, Hyperplasia, Multiple    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  48        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      9  1.9|
      Mucosa, Hyperplasia                  |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Incisor, Abscess                     |                                                                          |      1  2.0|
      Incisor, Developmental Malformation  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Pulmonary Artery, Inflammation, Acute|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      4  1.3|
      Atrioventricular Valve, Thrombosis   |                                                                          |      1  2.0|
      Epicardium, Fibrosis                 |                                                                          |      1  2.0|
      Interstitium, Fibrosis               |                                                                          |      4  1.0|
      Myocardium, Mineralization           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Corticomedullary Junction,           |                                                                          |            |
          Pigmentation                     |                                                                          |     46  1.0|
      Extra Adrenal Tissue, Accessory      |                                                                          |            |
          Adrenal Cortical Nodule          |                                                                          |      1     |
      Spindle Cell, Hyperplasia            |                                                                          |     49  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  49        |
      Cyst                                 |                                                                          |      4  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 6| 5| 6| 6| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Ectopic Thymus                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Distalis, Degeneration, Cystic  |                                                                          |      2  1.5|
      Pars Distalis, Hyperplasia           |                                                                          |     10  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Follicle, Cyst                       |                                                                          |      5  1.4|
      Follicular Cell, Hyperplasia         |                                                                          |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  47        |
      Abscess                              |                                                                          |      8  4.0|
      Atrophy                              |                                                                          |     24  2.2|
      Cyst                                 |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Pigmentation, Ceroid                 |                                                                          |     35  2.6|
      Follicle, Cyst                       |                                                                          |     11  2.8|
      Follicle, Hemorrhage                 |                                                                          |      1  3.0|
      Periovarian Tissue, Cyst             |                                                                          |      1  3.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Acute                           |                                                                          |      2  2.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic                         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  49        |
      Abscess                              |                                                                          |      1  2.0|
      Exudate, Purulent                    |                                                                          |      6  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrometra                           |                                                                          |      5  2.4|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     41  2.2|
      Endometrium, Inflammation, Acute     |                                                                          |      2  2.0|
      Endometrium, Inflammation, Chronic   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 6| 5| 6| 6| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
      Hypocellularity                      |                                                                          |      4  1.5|
      Myelofibrosis                        |                                                                          |     21  1.3|
      Erythroid Cell, Hyperplasia          |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |     13  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
      Iliac, Inflammation, Chronic         |                                                                          |      1  3.0|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      3  3.0|
      Mediastinal, Inflammation, Acute     |                                                                          |      1  2.0|
      Mediastinal, Inflammation, Chronic   |                                                                          |      2  2.5|
      Mesenteric, Angiectasis              |                                                                          |      1  1.0|
      Mesenteric, Autolysis                |                                                                          |      1  4.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |     11  1.8|
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |      2  2.5|
      Mesenteric, Inflammation, Acute      |                                                                          |      3  2.0|
      Mesenteric, Inflammation, Chronic    |                                                                          |      2  1.5|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      2  3.0|
      Renal, Inflammation, Acute           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |     23  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      6  1.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  18        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      3  1.7|
      Cortex, Necrosis                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 6| 5| 6| 6| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  49        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Duct, Dilatation                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  49        |
      Dermis, Fibrosis                     |                                                                          |      1  2.0|
      Dermis, Inflammation, Acute          |                                                                          |      2  2.0|
      Dermis, Inflammation, Chronic        |                                                                          |     25  1.4|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Cerebellum, Compression              |                                                                          |      1  3.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  3.0|
      Thalamus, Mineralization             |                                                                          |     44  1.6|
      Third Ventricle, Infiltration        |                                                                          |            |
          Cellular, Lipocyte               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Nerve, Demyelination                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Pleura, Inflammation, Acute          |                                                                          |      1  2.0|
      Pleura, Inflammation, Chronic        |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Nasolacrimal Duct, Exudate, Purulent |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Phthisis Bulbi                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 6| 5| 6| 6| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  49        |
      Casts Protein                        |                                                                          |      7  1.6|
      Infarct, Chronic                     |                                                                          |      3  2.0|
      Nephropathy                          |                                                                          |     24  1.5|
      Cortex, Metaplasia, Osseous          |                                                                          |      2  1.0|
      Corticomedullary Junction, Embolus   |                                                                          |            |
          Bacterial, Focal                 |                                                                          |      1  2.0|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |                                                                          |      6  2.7|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Degeneration, Hyaline           |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  47        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 2| 2| 8| 9| 2| 2| 2| 2| 5| 5| 2|             
                                           | 3| 3| 3| 8| 3| 4| 3| 7| 4| 4| 7| 4| 3| 4| 5| 5| 8| 9| 5| 5| 5| 8| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +|             
      Epithelium, Cytoplasmic Alteration   |                                              2                           |             
      Wall, Mucocele                       |                                                       1                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
      Lymphoid Tissue, Pigmentation        |                                  1           1                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +|             
      Submucosa, Inflammation, Acute       |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +|             
      Lymphoid Tissue, Pigmentation        |                         1                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia, Plasma |                                                                          |             
          Cell                             |                                                                          |             
      Lymphoid Tissue, Hyperplasia, Re Cell|                                                                          |             
      Lymphoid Tissue, Pigmentation        |       2     2  2  2  1  1  1     2  2  2  1  2        1     2  2     1  2|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |       2                                                                  |             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Inflammation, Acute                  |                                              1              2            |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                    +   |             
      Fat, Necrosis                        |                                                 4                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                          1               |             
      Duct, Ectasia                        |                                                                3         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |    1  1  1     2  1     2  2  1  2  1                 3  2              1|             
      Hyperkeratosis                       |    1           3     2  2     3  3  2  1              1  1        1      |             
      Inflammation, Chronic                |                                                                   2      |             
      Ulcer                                |    1     1     2  2  1  2  1  1  2  2  2  1  1        2  1  3  1        1|             
      Epithelium, Cyst                     |                                                                          |             
      Epithelium, Hyperplasia              |          2                    3     2     1     2              2  2      |             
      Epithelium, Hyperplasia, Multiple    |    2  3     2  2  2  2  2  3     2     2     1        2  2  2        2  2|             
      Submucosa, Edema                     |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 2| 2| 8| 9| 2| 2| 2| 2| 5| 5| 2|             
                                           | 3| 3| 3| 8| 3| 4| 3| 7| 4| 4| 7| 4| 3| 4| 5| 5| 8| 9| 5| 5| 5| 8| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |    2                    1        1  2        2                    1     2|             
      Ulcer                                |                               3                                          |             
      Submucosa, Edema                     |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
      Angiectasis                          |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Polyarteritis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Interstitium, Fibrosis               |                                  1           1                       1   |             
      Myocardium, Degeneration             | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                  1                                       |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     | 1  1  1  1  1  1  1  1  2  1     1  1  1  1  1        1  1  1  1  1     1|             
      Spindle Cell, Hyperplasia            | 2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2     2  2  2  2  2     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                 1        2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        2                                 |             
      Ectopic Thymus                       |                                                       1                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Degeneration, Cystic  |                                  2                                       |             
      Pars Distalis, Hyperplasia           | 2                 2  1  1           1  1              1                  |             
      Pars Intermedia, Hyperplasia         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicle, Cyst                       |       2  1     2                 2                                1      |             
      Follicular Cell, Hyperplasia         |                1                 2                          1  1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 2| 2| 8| 9| 2| 2| 2| 2| 5| 5| 2|             
                                           | 3| 3| 3| 8| 3| 4| 3| 7| 4| 4| 7| 4| 3| 4| 5| 5| 8| 9| 5| 5| 5| 8| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                                                    4                     |             
      Atrophy                              |    2  3        2           2     2     2  2                 2  2        2|             
      Hyperplasia, Tubular                 |                                                                          |             
      Pigmentation, Ceroid                 | 3  3  3  2  2  3  1  3     3  1  3     3  3  3        1  2  3  3  2  2  3|             
      Follicle, Cyst                       |          3                                            3  2        1      |             
      Follicle, Hemorrhage                 |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                              3                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Purulent                    |                      3              1              2                     |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  2  2  2     2  2  2  2  2  1  2  1  2  2  1        2  2  2  2  2  2  4|             
      Endometrium, Inflammation, Acute     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 1     2        1  2  2  1  1     1     1  2        1        2  1        3|             
      Myeloid Cell, Hyperplasia            |          3  2                                   3  3                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Mediastinal, Edema                   |                                                 3                        |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mesenteric, Autolysis                |                                                 4  4                     |             
      Mesenteric, Hyperplasia, Lymphoid    |       1     1                                               1            |             
      Mesenteric, Inflammation, Acute      |                                                                          |             
      Mesenteric, Pigmentation             |       1     1  2  1  2  2  2     2  2  1     2        2  2     2         |             
      Pancreatic, Hyperplasia, Lymphoid    |                3                                                         |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
      Renal, Lymphocyte, Necrosis          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Arteriole, Amyloid Deposition        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       2                  |             
      Hematopoietic Cell Proliferation     |          4           2              2     2     2     2              2   |             
      Hyperplasia, Lymphoid                | 2     1        3                 1        1                              |             
      Red Pulp, Depletion Cellular         |                               3                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  +  +  M  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  M  +|             
      Atrophy                              |                               4                                          |             
      Cyst                                 |                                                          1     1         |             
      Hyperplasia, Lymphoid                |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 2| 2| 8| 9| 2| 2| 2| 2| 5| 5| 2|             
                                           | 3| 3| 3| 8| 3| 4| 3| 7| 4| 4| 7| 4| 3| 4| 5| 5| 8| 9| 5| 5| 5| 8| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Chronic        |    1           1     1     2     1     2  2           2     1            |             
      Epidermis, Pigmentation              |                      2                                                   |             
      Subcutaneous Tissue, Abscess         |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Compression                |                                                                          |             
      Cerebrum, Degeneration               |                2                                                         |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      | 2                                                                        |             
      Thalamus, Mineralization             | 1  1  2  1        1     1        2  1     2     1  2  2  1  2  1     1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                               1                                          |             
      Pleura, Inflammation, Chronic        |                2        1                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Purulent                    |                               3                                          |             
      Foreign Body                         |                               3                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                               3                                          |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Acute                           |                                  1                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                      2  1           2                                    |             
      Infarct, Chronic                     | 2                                                                        |             
      Nephropathy                          | 1     1     2  1           1     1     1  1  1        1  1  1            |             
      Cortex, Metaplasia, Osseous          |    2           2  2              1                                       |             
      Glomerulus, Amyloid Deposition       |                                                                          |             
      Glomerulus, Inflammation,            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 2| 2| 8| 9| 2| 2| 2| 2| 5| 5| 2|             
                                           | 3| 3| 3| 8| 3| 4| 3| 7| 4| 4| 7| 4| 3| 4| 5| 5| 8| 9| 5| 5| 5| 8| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Membranoproliferative            |                                                    2                     |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Degeneration, Hyaline           |                                                                          |             
      Renal Tubule, Dilatation             |                   2                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 2| 5| 8| 3| 2| 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 3| 5| 8| 8| 8| 9| 9| 8| 5| 3| 9| 9| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Cytoplasmic Alteration   |                                                                          |             
      Wall, Mucocele                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                         1                                               1|             
      Lymphoid Tissue, Pigmentation        |             1           1                 1                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Inflammation, Acute       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Pigmentation        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia, Plasma |                                                                          |             
          Cell                             |                                                                         3|             
      Lymphoid Tissue, Hyperplasia, Re Cell|                                                                         3|             
      Lymphoid Tissue, Pigmentation        |             2  2  2  1        1  1  2  1     1  2  1           2  2  2   |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           3                             2|             
      Inflammation, Acute                  |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                      3                                                   |             
      Kupffer Cell, Hyperplasia            |                            3                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Necrosis                        |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |       1     2  2  2  1  1  1  1  1     2  2  2  2  1     3  2  1  2  2   |             
      Hyperkeratosis                       |                2           2  1                    1           1  1     2|             
      Inflammation, Chronic                |    2                                                              1      |             
      Ulcer                                |       1  1  2  2  2  1     1  1  1  1  2  2  2  2  2     2  2  2     2  1|             
      Epithelium, Cyst                     |                                              2                           |             
      Epithelium, Hyperplasia              |    1                       1  1  2  3  2  2           2     2  2  1  2  1|             
      Epithelium, Hyperplasia, Multiple    |       1  1  3  3  3  1  3                    2  3  3     3               |             
      Submucosa, Edema                     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 2| 5| 8| 3| 2| 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 3| 5| 8| 8| 8| 9| 9| 8| 5| 3| 9| 9| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                      2        2  1                                       |             
      Ulcer                                |                                                                          |             
      Submucosa, Edema                     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Angiectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                      +                                                   |             
      Aorta, Polyarteritis                 |                      3                                                   |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                1                                                     1   |             
      Interstitium, Fibrosis               |                                                                          |             
      Myocardium, Degeneration             |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                      2   |             
      Hypertrophy, Focal                   |                                                       2                  |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     |    1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Spindle Cell, Hyperplasia            |    2  2  2  2  2  2  2  1  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2              1                                                      |             
      Ectopic Thymus                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Angiectasis           |                                        1                    3            |             
      Pars Distalis, Degeneration, Cystic  |                                           1                 1            |             
      Pars Distalis, Hyperplasia           |                            2        3        3                    2      |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |             1                                                            |             
      Ultimobranchial Cyst                 |                                     2     1                              |             
      Follicle, Cyst                       |                            1                                            2|             
      Follicular Cell, Hyperplasia         |       1  1     1           1     2                       2  1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 2| 5| 8| 3| 2| 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 3| 5| 8| 8| 8| 9| 9| 8| 5| 3| 9| 9| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                                           4                              |             
      Atrophy                              |    2  2  2  2  2  3  2  1  2  2        2  2  2  2  2     2           2  2|             
      Hyperplasia, Tubular                 |                                                                      2   |             
      Pigmentation, Ceroid                 |       3  3  3  3  3     2  3  2  2  2  2  2  2  2  3  2  2  2  2  2  3  3|             
      Follicle, Cyst                       |       2  1     2           2        2           3     2     2     3      |             
      Follicle, Hemorrhage                 |                2                                                         |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Purulent                    |                                           2                              |             
      Hemorrhage                           |       2                                                                  |             
      Hydrometra                           |                         3                                                |             
      Endometrium, Hyperplasia, Cystic     |       2  2  3  2  2  2  2  2  2  2  2  3  2  2  2  2     2  2  2  3  2   |             
      Endometrium, Inflammation, Acute     |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                1        1           1  1  1  1  1  1     2     1  2  2   |             
      Myeloid Cell, Hyperplasia            |                1                          3                             4|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Plasma Cell      |                                           3                             4|             
      Mediastinal, Edema                   |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                           2                              |             
      Mesenteric, Autolysis                |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |          1        1        2              2                    1        1|             
      Mesenteric, Inflammation, Acute      |                                           1                              |             
      Mesenteric, Pigmentation             |    1     1  2        2  1     1  1  2  2  1     1  2           2  1  2   |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                           3                             3|             
      Renal, Lymphocyte, Necrosis          |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                           1                              |             
      Inflammation, Granulomatous          |                      3                                                   |             
      Arteriole, Amyloid Deposition        |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |    3  1              2  2  3              3  2  2     2                 4|             
      Hyperplasia, Lymphoid                |          2                       1                             1     1   |             
      Red Pulp, Depletion Cellular         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4                 2                                                  3|             
      Cyst                                 |                         1                       1                        |             
      Hyperplasia, Lymphoid                |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 2| 5| 8| 3| 2| 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 3| 5| 8| 8| 8| 9| 9| 8| 5| 3| 9| 9| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia                  |                      2     3                          1                  |             
      Duct, Dilatation                     |             2              2                 1                           |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Chronic        |          2  2  2     2  2     2        1     2     2     2  2        2   |             
      Epidermis, Pigmentation              |                                                                          |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Compression                |             2                                         2                  |             
      Cerebrum, Degeneration               |                                                                          |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Thalamus, Mineralization             |       1  1  1  1  2  2     1  1        2  1  1  1  2     1  1  1  3     2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Pleura, Inflammation, Chronic        |                                                                      1   |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Purulent                    |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute                  |                               1                                          |             
      Inflammation, Chronic                |                                                                          |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |       1           1  3                                                   |             
      Infarct, Chronic                     |                                                                          |             
      Nephropathy                          |          1  1  1              1  2  1  1        1  1  1  1  1  1     1   |             
      Cortex, Metaplasia, Osseous          |                      2                          1                        |             
      Glomerulus, Amyloid Deposition       |                      4                                                   |             
      Glomerulus, Inflammation,            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 5| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 2| 5| 8| 3| 2| 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                                           | 3| 5| 8| 8| 8| 9| 9| 8| 5| 3| 9| 9| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Membranoproliferative            |                                           2                             1|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Degeneration, Hyaline           |    3                       2                                             |             
      Renal Tubule, Dilatation             |                                        2                                2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  46        |
      Epithelium, Cytoplasmic Alteration   |                                                                          |      1  2.0|
      Wall, Mucocele                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  46        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      2  1.0|
      Lymphoid Tissue, Pigmentation        |                                                                          |      5  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  46        |
      Submucosa, Inflammation, Acute       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  46        |
      Lymphoid Tissue, Pigmentation        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  47        |
      Lymphoid Tissue, Hyperplasia, Plasma |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
      Lymphoid Tissue, Hyperplasia, Re Cell|                                                                          |      1  3.0|
      Lymphoid Tissue, Pigmentation        |                                                                          |     31  1.6|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  48        |
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
      Inflammation, Acute                  |                                                                          |      2  1.5|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  3.0|
      Kupffer Cell, Hyperplasia            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Necrosis                        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  47        |
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Abscess                              |                                                                          |     32  1.6|
      Hyperkeratosis                       |                                                                          |     18  1.7|
      Inflammation, Chronic                |                                                                          |      3  1.7|
      Ulcer                                |                                                                          |     38  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Cyst                     |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |     20  1.8|
      Epithelium, Hyperplasia, Multiple    |                                                                          |     27  2.2|
      Submucosa, Edema                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  45        |
      Mineralization                       |                                                                          |     10  1.6|
      Ulcer                                |                                                                          |      1  3.0|
      Submucosa, Edema                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Angiectasis                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Polyarteritis                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  49        |
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Interstitium, Fibrosis               |                                                                          |      3  1.0|
      Myocardium, Degeneration             |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  48        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      2  1.5|
      Corticomedullary Junction,           |                                                                          |            |
          Pigmentation                     |                                                                          |     45  1.0|
      Spindle Cell, Hyperplasia            |                                                                          |     47  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  47        |
      Hyperplasia                          |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  49        |
      Cyst                                 |                                                                          |      3  1.7|
      Ectopic Thymus                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  47        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.0|
      Pars Distalis, Degeneration, Cystic  |                                                                          |      3  1.3|
      Pars Distalis, Hyperplasia           |                                                                          |     11  1.7|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Ultimobranchial Cyst                 |                                                                          |      2  1.5|
      Follicle, Cyst                       |                                                                          |      7  1.6|
      Follicular Cell, Hyperplasia         |                                                                          |     11  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  48        |
      Abscess                              |                                                                          |      2  4.0|
      Atrophy                              |                                                                          |     28  2.0|
      Hyperplasia, Tubular                 |                                                                          |      1  2.0|
      Pigmentation, Ceroid                 |                                                                          |     43  2.4|
      Follicle, Cyst                       |                                                                          |     13  2.2|
      Follicle, Hemorrhage                 |                                                                          |      1  2.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  49        |
      Exudate, Purulent                    |                                                                          |      4  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrometra                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     43  2.1|
      Endometrium, Inflammation, Acute     |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
      Myelofibrosis                        |                                                                          |     26  1.4|
      Myeloid Cell, Hyperplasia            |                                                                          |      7  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      2  3.5|
      Mediastinal, Edema                   |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mesenteric, Autolysis                |                                                                          |      2  4.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      9  1.2|
      Mesenteric, Inflammation, Acute      |                                                                          |      1  1.0|
      Mesenteric, Pigmentation             |                                                                          |     29  1.6|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Lymphocyte, Necrosis          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  49        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Arteriole, Amyloid Deposition        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |     17  2.4|
      Hyperplasia, Lymphoid                |                                                                          |      9  1.4|
      Red Pulp, Depletion Cellular         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  39        |
      Atrophy                              |                                                                          |      4  3.3|
      Cyst                                 |                                                                          |      4  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  48        |
      Acinus, Hyperplasia                  |                                                                          |      3  2.0|
      Duct, Dilatation                     |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  49        |
      Dermis, Inflammation, Chronic        |                                                                          |     21  1.7|
      Epidermis, Pigmentation              |                                                                          |      1  2.0|
      Subcutaneous Tissue, Abscess         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  49        |
      Cerebrum, Compression                |                                                                          |      2  2.0|
      Cerebrum, Degeneration               |                                                                          |      1  2.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Thalamus, Mineralization             |                                                                          |     35  1.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  49        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Pleura, Inflammation, Chronic        |                                                                          |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 6| 6| 6| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  49        |
      Exudate, Purulent                    |                                                                          |      1  3.0|
      Foreign Body                         |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  49        |
      Casts Protein                        |                                                                          |      6  1.7|
      Infarct, Chronic                     |                                                                          |      1  2.0|
      Nephropathy                          |                                                                          |     26  1.1|
      Cortex, Metaplasia, Osseous          |                                                                          |      6  1.7|
      Glomerulus, Amyloid Deposition       |                                                                          |      1  4.0|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |                                                                          |      3  1.7|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Degeneration, Hyaline           |                                                                          |      2  2.5|
      Renal Tubule, Dilatation             |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 0| 2| 8| 2| 4| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 3| 3| 3| 1| 3| 4| 4| 4| 1| 4| 4| 5| 7| 1| 5| 5| 5| 5| 5| 5| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +              +              +           +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +              +              +           A  +  M     +                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
      Lymphoid Tissue, Pigmentation        |                      1                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Pigmentation        |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Pigmentation        |    2  2           1  1  1  1     2  2  2              1           1      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                     1                                    |             
      Inflammation, Acute                  |                                     2                                    |             
      Mitotic Alteration                   |                                                       3                  |             
      Hepatocyte, Necrosis                 |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +                                                         |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +              +              +           +  +  +     +     +            |             
      Inflammation, Chronic                |                                                                          |             
      Acinar Cell, Atrophy                 |                                                                          |             
      Duct, Ectasia                        |                                                             3            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +              +              +           +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |    2  2  1     1  1        1  1  2     2           2     2     1  2  1   |             
      Hyperkeratosis                       |                               3                                          |             
      Inflammation, Chronic                |                               2                                          |             
      Ulcer                                |       2     1     1  1  2  2  2  1     1           2  1  1     1  1  1   |             
      Epithelium, Hyperplasia              |    2  2  1  2  1                    2  2           2     2           1  1|             
      Epithelium, Hyperplasia, Multiple    |                   2  2  2  2  2  2           3        1        2  3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               1                       1              2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +              +              +           +  +  +     +                  |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 0| 2| 8| 2| 4| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 3| 3| 3| 1| 3| 4| 4| 4| 1| 4| 4| 5| 7| 1| 5| 5| 5| 5| 5| 5| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +              +              +           +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +              +              +           +  +  +     +                  |             
      Hypertrophy, Diffuse                 |                               3                                          |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     |                1                                                         |             
      Extra Adrenal Tissue, Accessory      |                                                                          |             
          Adrenal Cortical Nodule          |                                                 2                        |             
      Spindle Cell, Hyperplasia            | 2              2              2           2  2  3     2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +              +              +           +  +  +     +                  |             
      Hyperplasia                          |                                                 1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +           +              +           +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +              +              +           +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +              +              +           +  +  +     +                  |             
      Pars Distalis, Hyperplasia           |                                                 2     2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +              +              +           +  +  +     +                  |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +     +     +  +  +  +     +     +  +  +     +     +  +     +   |             
      Abscess                              |                                     4                                    |             
      Atrophy                              | 2                    2        2           3  3  2                        |             
      Cyst                                 |                      2  2                                                |             
      Pigmentation, Ceroid                 | 2                    2  2     2           2  2  2     1     2  2         |             
      Follicle, Cyst                       |          2                 3                                         3   |             
      Follicle, Hemorrhage                 |                                                       4                  |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +     +  +  +  +     +     +  +  +     +|             
      Hydrometra                           |    4                    2                                                |             
      Endometrium, Cyst                    | 1                                            1                           |             
      Endometrium, Hyperplasia, Cystic     |       3  2  2     2     2  2     2     2                    2  3  2     2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |       2  1  1     1  2     1     1     1  1        2        1     1  1  1|             
      Myeloid Cell, Hyperplasia            |                               2     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Abscess                  |                                                                          |             
      Mesenteric, Angiectasis              |                      2                                                   |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 0| 2| 8| 2| 4| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 3| 3| 3| 1| 3| 4| 4| 4| 1| 4| 4| 5| 7| 1| 5| 5| 5| 5| 5| 5| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Proliferation                    |                                                                         2|             
      Mesenteric, Hyperplasia, Lymphoid    |          2                    3     2                             2      |             
      Mesenteric, Inflammation, Acute      |                                                                          |             
      Mesenteric, Inflammation, Chronic    |                               3                                          |             
      Mesenteric, Pigmentation             |    2  2              2  2  1     2  2  1     1                           |             
      Pancreatic, Hyperplasia, Lymphoid    |                               4                                          |             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +              +              +           +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +     +              +           +  +  +     +  +        +      |             
      Hematopoietic Cell Proliferation     | 2              2                                3     2                  |             
      Hyperplasia, Lymphoid                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +     +              M           +  M  +     I  +               |             
      Atrophy                              | 2                                               2                        |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +              +              +           +  +  +     +                  |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
      Duct, Ectasia                        |                               1                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +   |             
      Dermis, Inflammation, Chronic        |    2  1     2  2  1  2                 1  2                 2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +              +              +           +  +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +              +              +           +  +  +     +                  |             
      Cerebrum, Compression                |                               1                                          |             
      Thalamus, Mineralization             | 1              2              2           1     2                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           2                              |             
      Inflammation, Chronic                |                                                                2         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Foreign Body                 |                                                                          |             
      Artery, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +              +              +           +  +  +     +                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +              +              +           +  +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 0| 2| 8| 2| 4| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 3| 3| 3| 1| 3| 4| 4| 4| 1| 4| 4| 5| 7| 1| 5| 5| 5| 5| 5| 5| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                      +|             
      Phthisis Bulbi                       |                                  3                                      3|             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                       +                                               +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +              +              +           +  +  +     +  +               |             
      Nephropathy                          |                               1                                          |             
      Glomerulus, Inflammation,            |                                                                          |             
          Membranoproliferative            |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Renal Tubule, Degeneration,     |                                                                          |             
           Hyaline                         |                                                 3                        |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Renal Tubule, Pigmentation      |                                                                          |             
      Renal Tubule, Mineralization         |                                                       2                  |             
      Renal Tubule, Pigmentation           |                                                       3                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +              +              +           A  +  +     +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 0| 2| 2| 7| 2| 2| 2| 6| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 8| 6| 8| 9| 2| 9| 9| 9| 7| 6| 1| 9| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +        +           +  +  +     +                                +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +        +        +  +  A  +     +                                +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |          2        2                                3                     |             
      Lymphoid Tissue, Pigmentation        |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Pigmentation        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Pigmentation        | 1                       1  2        1     1     1  2  1  1  1  2  2  1  1|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       1  2                                2        1              1     3|             
      Inflammation, Acute                  |                2                                                         |             
      Mitotic Alteration                   |                                                                          |             
      Hepatocyte, Necrosis                 |                   1                                                      |             
      Hepatocyte, Vacuolization Cytoplasmic|    1                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +           +                  |             
      Fat, Necrosis                        |                                           2           3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +        +           +  +  +     +                                +|             
      Inflammation, Chronic                |                                                                         2|             
      Acinar Cell, Atrophy                 |                                                                         2|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +        +           +  +  +     +                                +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              | 1     1  2  2        2     1     2  1     1     1  2     1  2     2      |             
      Hyperkeratosis                       |    1                 1                                                   |             
      Inflammation, Chronic                |    1                                                                     |             
      Ulcer                                | 2     2  2  2     2  2     1  1  2     1        1  2     1  2     1      |             
      Epithelium, Hyperplasia              | 1  2  1        1        2  2     2  2  2  1  1  1  2        2  1  2      |             
      Epithelium, Hyperplasia, Multiple    |          2  3     2  3        3                                      1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2                                2     1                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +        +           +  +  +     +                                +|             
      Inflammation, Chronic                |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 0| 2| 2| 7| 2| 2| 2| 6| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 8| 6| 8| 9| 2| 9| 9| 9| 7| 6| 1| 9| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +        +           +  +  +     +                                +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +        +           +  +  +     +                                +|             
      Hypertrophy, Diffuse                 |                                                                          |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     |                                  1     2                                 |             
      Extra Adrenal Tissue, Accessory      |                                                                          |             
          Adrenal Cortical Nodule          |                                                                          |             
      Spindle Cell, Hyperplasia            |       2        2           2  2  3     4                                2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +        +           +  +  +     +                                +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +        +           +  +  +     +                                +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +        +           +  +  +     +                                +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +     +           +  +  +  +  +                                +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +        +           +  +  +     +                                +|             
      Ultimobranchial Cyst                 |       2                                                                  |             
      Follicular Cell, Hyperplasia         |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +  +  +           +  +  +     +     +  +        +        +     +|             
      Abscess                              |                                                                         4|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Pigmentation, Ceroid                 |       2        1                 2     2                                 |             
      Follicle, Cyst                       |          2                 3     2     2     3  2                 2      |             
      Follicle, Hemorrhage                 |                                                                          |             
      Periovarian Tissue, Cyst             |             3                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +     +  +     +  +  +  +  +  +  +     +     +  +  +     +  +  +  +|             
      Hydrometra                           |                3                                                         |             
      Endometrium, Cyst                    |                                  2                                       |             
      Endometrium, Hyperplasia, Cystic     |    2  2     1  1     3  3  3  2     2  1     3     2  2  3     2  2  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |          1  2     1  1                 1  1     1  1  1  1     2  1  1   |             
      Myeloid Cell, Hyperplasia            |       2                    2                                            4|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Abscess                  |                                                                         3|             
      Mesenteric, Angiectasis              |                                           1                              |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 0| 2| 2| 7| 2| 2| 2| 6| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 8| 6| 8| 9| 2| 9| 9| 9| 7| 6| 1| 9| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                      2  1                             2  1               |             
      Mesenteric, Inflammation, Acute      |                                                             1            |             
      Mesenteric, Inflammation, Chronic    |                                                                          |             
      Mesenteric, Pigmentation             | 2           1  1     1     1     1  1     2  2  2  2  2  1  2  2  1  1   |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +     +           +  +  +     +                                +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +     +  +        +  +  +     +  +     +        +     +        +|             
      Hematopoietic Cell Proliferation     |       2  2     2  3        3  3  2        3              3     2        4|             
      Hyperplasia, Lymphoid                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +     +           M  +  +     +                                +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                        1                                1|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +     +           +  +  +     +                                +|             
      Acinus, Hyperplasia                  |          2                                                               |             
      Duct, Dilatation                     |          3                                                               |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Chronic        | 1  2  2  2  2              2  2  1  1  2  2  1  1  4     2  2     2  1  2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +        +           +  +  +     +                                +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +        +           +  +  +     +                                +|             
      Cerebrum, Compression                |                                                                          |             
      Thalamus, Mineralization             |                1           2  2                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                           1                              |             
      Artery, Foreign Body                 |                                        2                                 |             
      Artery, Mineralization               |                                                       1                  |             
                                            __________________________________________________________________________|             
   Nose                                    |       +        +           +  +  +     +                                +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +        +           +  +  +     +                                +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 0| 2| 2| 7| 2| 2| 2| 6| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|             
                                           | 5| 8| 6| 8| 9| 2| 9| 9| 9| 7| 6| 1| 9| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +        +           +  +  +     +                                +|             
      Nephropathy                          |                                                                          |             
      Glomerulus, Inflammation,            |                                                                          |             
          Membranoproliferative            |                                                                         3|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Renal Tubule, Degeneration,     |                                                                          |             
           Hyaline                         |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Renal Tubule, Pigmentation      |                                  2                                       |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +        +           +  A  +     +                                +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 7| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 0| 5| 5| 6| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  48        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      3  2.3|
      Lymphoid Tissue, Pigmentation        |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  47        |
      Erosion                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  48        |
      Lymphoid Tissue, Pigmentation        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  48        |
      Lymphoid Tissue, Pigmentation        |                                                                          |     25  1.4|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      7  1.6|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Mitotic Alteration                   |                                                                          |      1  3.0|
      Hepatocyte, Necrosis                 |                                                                          |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  15        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Acinar Cell, Atrophy                 |                                                                          |      1  2.0|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Abscess                              |                                                                          |     28  1.5|
      Hyperkeratosis                       |                                                                          |      3  1.7|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Ulcer                                |                                                                          |     30  1.5|
      Epithelium, Hyperplasia              |                                                                          |     27  1.6|
      Epithelium, Hyperplasia, Multiple    |                                                                          |     16  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Mineralization                       |                                                                          |      6  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 7| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 0| 5| 5| 6| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  14        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  14        |
      Hypertrophy, Diffuse                 |                                                                          |      1  3.0|
      Corticomedullary Junction,           |                                                                          |            |
          Pigmentation                     |                                                                          |      3  1.3|
      Extra Adrenal Tissue, Accessory      |                                                                          |            |
          Adrenal Cortical Nodule          |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            |                                                                          |     14  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  14        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  16        |
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  14        |
      Ultimobranchial Cyst                 |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  28        |
      Abscess                              |                                                                          |      2  4.0|
      Atrophy                              |                                                                          |      6  2.3|
      Cyst                                 |                                                                          |      2  2.0|
      Pigmentation, Ceroid                 |                                                                          |     14  1.9|
      Follicle, Cyst                       |                                                                          |     10  2.4|
      Follicle, Hemorrhage                 |                                                                          |      1  4.0|
      Periovarian Tissue, Cyst             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  39        |
      Hydrometra                           |                                                                          |      3  3.0|
      Endometrium, Cyst                    |                                                                          |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 7| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 0| 5| 5| 6| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Hyperplasia, Cystic     |                                                                          |     29  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
      Myelofibrosis                        |                                                                          |     27  1.2|
      Myeloid Cell, Hyperplasia            |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Mesenteric, Abscess                  |                                                                          |      1  3.0|
      Mesenteric, Angiectasis              |                                                                          |      2  1.5|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      8  1.9|
      Mesenteric, Inflammation, Acute      |                                                                          |      1  1.0|
      Mesenteric, Inflammation, Chronic    |                                                                          |      1  3.0|
      Mesenteric, Pigmentation             |                                                                          |     26  1.5|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  4.0|
      Pancreatic, Inflammation,            |                                                                          |            |
          Granulomatous                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  25        |
      Hematopoietic Cell Proliferation     |                                                                          |     15  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  14        |
      Atrophy                              |                                                                          |      2  2.0|
      Cyst                                 |                                                                          |      2  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  15        |
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Duct, Dilatation                     |                                                                          |      1  3.0|
      Duct, Ectasia                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  48        |
      Dermis, Inflammation, Chronic        |                                                                          |     28  1.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  14        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 7| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 0| 5| 5| 6| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  14        |
      Cerebrum, Compression                |                                                                          |      1  1.0|
      Thalamus, Mineralization             |                                                                          |      8  1.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  49        |
      Congestion                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Artery, Foreign Body                 |                                                                          |      1  2.0|
      Artery, Mineralization               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  14        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Phthisis Bulbi                       |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  15        |
      Nephropathy                          |                                                                          |      1  1.0|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |                                                                          |      1  3.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Renal Tubule, Degeneration,     |                                                                          |            |
           Hyaline                         |                                                                          |      1  3.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Renal Tubule, Pigmentation      |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 6| 2| 1| 2| 2| 0| 2| 2| 2| 8|             
                                           | 7| 0| 3| 3| 3| 3| 3| 4| 4| 2| 5| 4| 4| 4| 5| 9| 5| 0| 5| 5| 3| 5| 8| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +                       +  +              +     +        +           +|             
      Inflammation, Chronic                | 3                                                                       2|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A                       +  +              +     A        +           +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                         2                       2                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2                                                                        |             
      Polyarteritis                        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
      Lymphoid Tissue, Pigmentation        |       1  2     2  1                                   2  1               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                          3               |             
      Inflammation, Acute                  |                                        1                                 |             
      Inflammation, Chronic                |             1        1                                                   |             
      Polyarteritis                        |                                                    3                     |             
      Hepatocyte, Vacuolization Cytoplasmic|                                  2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +                       +  +              +     +        +           +|             
      Inflammation, Acute                  |                               2                                          |             
      Polyarteritis                        |                                                    3                     |             
      Acinar Cell, Atrophy                 |                                                                         1|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +                       +  +              +     +        +           +|             
      Inflammation, Acute                  |    1                                                                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                    1           1  1      |             
      Hyperkeratosis                       |                                                                   2      |             
      Ulcer                                |                                                                2  1      |             
      Epithelium, Hyperplasia              |                                              1     2              3      |             
      Epithelium, Hyperplasia, Multiple    |                                                                2     3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                     2                                    |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |             1                                                            |             
      Mucosa, Cyst                         |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 6| 2| 1| 2| 2| 0| 2| 2| 2| 8|             
                                           | 7| 0| 3| 3| 3| 3| 3| 4| 4| 2| 5| 4| 4| 4| 5| 9| 5| 0| 5| 5| 3| 5| 8| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +                       +  +              +     +        +           +|             
      Inflammation, Chronic                |                                                    3                     |             
      Myocardium, Inflammation, Acute      |                                                                          |             
      Myocardium, Inflammation             |                                                                          |             
      Myocardium, Mineralization           |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +                       +  +              +     +        +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +                       +  +              +     +        +           +|             
      Congestion                           |    2                                                                     |             
      Inflammation, Acute                  |                               2                                          |             
      Spindle Cell, Hyperplasia            | 1                          2  2              3     2        2           2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +                       +  +              +     +        +           +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +                       +  +              +     +        +           +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +                       +  +              +     M        +           +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +                       +  +  +     +     +     +     +  +  +        +|             
      Pars Distalis, Angiectasis           |                            4                                             |             
      Pars Distalis, Hyperplasia           |                                                    2                    1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                          +  +              +     +        +           +|             
      Ultimobranchial Cyst                 |                               1                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +           +           +  +              +  +  +        +           +|             
      Abscess                              |                               4                                          |             
      Atrophy                              |                2           3                       3                     |             
      Pigmentation, Ceroid                 |                2           3                 1              2           3|             
      Polyarteritis                        |                                                    2                     |             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +     +  +     +  +|             
      Abscess                              |                                                                          |             
      Exudate, Purulent                    |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                                                          |             
      Polyarteritis                        |                                                    2                     |             
      Endometrium, Cyst                    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |       3  3  2  2     2  3  2     2        2     2     3     1        1   |             
      Endometrium, Inflammation, Acute     |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 6| 2| 1| 2| 2| 0| 2| 2| 2| 8|             
                                           | 7| 0| 3| 3| 3| 3| 3| 4| 4| 2| 5| 4| 4| 4| 5| 9| 5| 0| 5| 5| 3| 5| 8| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypocellularity                      |                                     2                                    |             
      Myelofibrosis                        |       1  2     1     1  1                 2     1              1         |             
      Myeloid Cell, Hyperplasia            |    2                          3                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Edema                         |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Mediastinal, Abscess                 |                               3                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Inflammation, Acute     |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                2     2  2        2        3                       1      |             
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |             
      Mesenteric, Pigmentation             |                                                       1                  |             
      Mesenteric, Lymphocyte, Necrosis     | 2                                                                        |             
      Renal, Abscess                       |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +     +                 +  +              +     +        +  +        +|             
      Inflammation, Acute                  |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +                 +  +              +     +        +  +        +|             
      Hematopoietic Cell Proliferation     |                            3  3                                3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M                       +  M              +     M        +           M|             
      Atrophy                              | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +                       +  +              +     +        +           +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Acute          |                                              2                           |             
      Dermis, Inflammation, Chronic        | 2     2  2  2     2     2                 2     2        2     2        2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +                       +  +              +     +        +           +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +                       +  +              +     +        +           +|             
      Thalamus, Mineralization             |                            2  1              1     2        1           2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                                                                     |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Acute                  | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 6| 2| 1| 2| 2| 0| 2| 2| 2| 8|             
                                           | 7| 0| 3| 3| 3| 3| 3| 4| 4| 2| 5| 4| 4| 4| 5| 9| 5| 0| 5| 5| 3| 5| 8| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                   2      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Mineralization             |                                                          1               |             
      Artery, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +                       +  +              +     +        +           +|             
      Sinus, Exudate, Acute                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +                       +  +              +     +        +           +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
      Cornea, Inflammation, Chronic        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +                 +  +              +     +     +  +           +|             
      Infarct, Chronic                     |                                                          2               |             
      Nephropathy                          |                                                    3                     |             
      Glomerulus, Inflammation,            |                                                                          |             
          Membranoproliferative            |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Renal Tubule, Degeneration,     |                                                                          |             
           Hyaline                         |                            2                                             |             
      Renal Tubule, Hypertrophy            |                                                          2               |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +                       +  +              +     +        +           +|             
      Polyarteritis                        |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 8| 2| 2| 3| 7| 3| 3| 3| 1| 3| 2| 4| 3| 3| 3| 1| 3| 3| 6| 3|             
                                           | 9| 9| 9| 3| 9| 7| 9| 9| 0| 1| 0| 0| 0| 9| 0| 0| 7| 0| 0| 0| 6| 0| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +     +           +           +     A  +           +        +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |          +     +           +           +     A  +           +        A   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                         3           2     2                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
      Inflammation, Chronic                |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  A  +|             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  A  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                         1                                                |             
      Lymphoid Tissue, Pigmentation        | 1     1           1     1  1     1                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   3        1                                         2   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Polyarteritis                        |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                2                                1                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +     +           +           +     A  +           +        M   |             
      Inflammation, Acute                  |                                                                          |             
      Polyarteritis                        |                                                                          |             
      Acinar Cell, Atrophy                 |          4                                      1                        |             
      Duct, Ectasia                        |          4                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +     +           +           +     +  +           +        +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                      2                                                  1|             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |             1        2                    1                             1|             
      Epithelium, Hyperplasia              | 1        1              2     1  1        2                              |             
      Epithelium, Hyperplasia, Multiple    |             2        2                                                  2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                    2                     |             
      Mineralization                       |                2           2                                            1|             
      Mucosa, Cyst                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 8| 2| 2| 3| 7| 3| 3| 3| 1| 3| 2| 4| 3| 3| 3| 1| 3| 3| 6| 3|             
                                           | 9| 9| 9| 3| 9| 7| 9| 9| 0| 1| 0| 0| 0| 9| 0| 0| 7| 0| 0| 0| 6| 0| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +     +           +           +     +  +           +        +   |             
      Inflammation, Chronic                |                                                                          |             
      Myocardium, Inflammation, Acute      |                                                                      1   |             
      Myocardium, Inflammation             |                            2                                             |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +     +           +           +     A  +           +        +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +     +           +           +     A  +           +        +   |             
      Congestion                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Spindle Cell, Hyperplasia            |          2     2           2           2        3           2        2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +     +           +           +     A  +           +        +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +     +           +           +     A  +     +     +        M   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          M     M           +           +     M  M           +        +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +     +  +        +        +  +     A  +           +  +     +   |             
      Pars Distalis, Angiectasis           |    4                                                                     |             
      Pars Distalis, Hyperplasia           |                            3                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +     +           +           +     A  +           +        +   |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +     +  +        +           +     M  +     +     +        +   |             
      Abscess                              |                   4        4                                         4   |             
      Atrophy                              |          2                             2        3                        |             
      Pigmentation, Ceroid                 |          2     1                       2        3                        |             
      Polyarteritis                        |                                                                          |             
      Follicle, Cyst                       |                                                             2            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  A  +  +     +  +  +     +   |             
      Abscess                              |                   4                                                      |             
      Exudate, Purulent                    |                                                                      3   |             
      Hemorrhage                           |                2                                                         |             
      Hydrometra                           |                            2                                             |             
      Polyarteritis                        |                                                                          |             
      Endometrium, Cyst                    |                                                             1            |             
      Endometrium, Hyperplasia, Cystic     | 3  2  2  2  2  3     4        2  3  2     2     1  3     3     3         |             
      Endometrium, Inflammation, Acute     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 8| 2| 2| 3| 7| 3| 3| 3| 1| 3| 2| 4| 3| 3| 3| 1| 3| 3| 6| 3|             
                                           | 9| 9| 9| 3| 9| 7| 9| 9| 0| 1| 0| 0| 0| 9| 0| 0| 7| 0| 0| 0| 6| 0| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hypocellularity                      |                                     1                                    |             
      Myelofibrosis                        | 2        1  1                       1     1                    1         |             
      Myeloid Cell, Hyperplasia            |                   3        3                                         2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Iliac, Edema                         |                   3                                                      |             
      Iliac, Hyperplasia, Plasma Cell      |                   3                                                      |             
      Mediastinal, Abscess                 |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                            4                                             |             
      Mediastinal, Inflammation, Acute     |                            2                                             |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                   3        3                                             |             
      Mesenteric, Hyperplasia, Lymphoid    |          2     2              2     2     2     2  2  2                  |             
      Mesenteric, Hyperplasia, Plasma Cell |                            2                                             |             
      Mesenteric, Pigmentation             | 1           1                          1                                 |             
      Mesenteric, Lymphocyte, Necrosis     |                                                                          |             
      Renal, Abscess                       |                                                                      2   |             
      Renal, Hyperplasia, Plasma Cell      |                                                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +     +        +  +           +     A  +        +  +        +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +  +  +  +        +           +     A  +        +  +     +  +   |             
      Hematopoietic Cell Proliferation     |                   3        4                    3                    3   |             
                                            __________________________________________________________________________|             
   Thymus                                  |          M  +  M           +           M     M  M        +  M        M   |             
      Atrophy                              |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          +     +           +           +     M  +           +        +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Acute          |                                                                          |             
      Dermis, Inflammation, Chronic        |    2  2     2           2  2  1  2  1     2        2     2     2  2     2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +     +           +           +     +  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +     +           +           +     A  +           +        +   |             
      Thalamus, Mineralization             |          2     2           2           2        1                    1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |    2                                                                     |             
      Inflammation, Acute                  |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 8| 2| 2| 3| 7| 3| 3| 3| 1| 3| 2| 4| 3| 3| 3| 1| 3| 3| 6| 3|             
                                           | 9| 9| 9| 3| 9| 7| 9| 9| 0| 1| 0| 0| 0| 9| 0| 0| 7| 0| 0| 0| 6| 0| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1                                                                     |             
      Alveolus, Mineralization             |                                                                          |             
      Artery, Mineralization               |                   2                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    |          +     +           +           +     A  +           +        +   |             
      Sinus, Exudate, Acute                |                                        1                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +     +           +           +     A  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Cornea, Inflammation, Chronic        |             2                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +     +           +           +     M  +           +        +   |             
      Infarct, Chronic                     |                                                                          |             
      Nephropathy                          |                                                 1                        |             
      Glomerulus, Inflammation,            |                                                                          |             
          Membranoproliferative            |                            2                                             |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Renal Tubule, Degeneration,     |                                                                          |             
           Hyaline                         |                                                             3            |             
      Renal Tubule, Hypertrophy            |                                                                          |             
      Renal Tubule, Mineralization         |                                        1                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +     +           +           +     A  +           +        +   |             
      Polyarteritis                        |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  15        |
      Inflammation, Chronic                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  47        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  48        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Polyarteritis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  46        |
      Polyarteritis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  46        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  1.0|
      Lymphoid Tissue, Pigmentation        |                                                                          |     12  1.3|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.3|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Polyarteritis                        |                                                                          |      1  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  14        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Polyarteritis                        |                                                                          |      1  3.0|
      Acinar Cell, Atrophy                 |                                                                          |      3  2.0|
      Duct, Ectasia                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  16        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Abscess                              |                                                                          |      5  1.2|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      6  1.3|
      Epithelium, Hyperplasia              |                                                                          |      9  1.6|
      Epithelium, Hyperplasia, Multiple    |                                                                          |      5  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  48        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      4  1.5|
      Mucosa, Cyst                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  16        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Myocardium, Inflammation, Acute      |                                                                          |      1  1.0|
      Myocardium, Inflammation             |                                                                          |      1  2.0|
      Myocardium, Mineralization           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  15        |
      Congestion                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            |                                                                          |     14  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  23        |
      Pars Distalis, Angiectasis           |                                                                          |      2  4.0|
      Pars Distalis, Hyperplasia           |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  15        |
      Ultimobranchial Cyst                 |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  20        |
      Abscess                              |                                                                          |      4  4.0|
      Atrophy                              |                                                                          |      6  2.5|
      Pigmentation, Ceroid                 |                                                                          |      9  2.1|
      Polyarteritis                        |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  41        |
      Abscess                              |                                                                          |      1  4.0|
      Exudate, Purulent                    |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrometra                           |                                                                          |      1  2.0|
      Polyarteritis                        |                                                                          |      1  2.0|
      Endometrium, Cyst                    |                                                                          |      1  1.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     28  2.3|
      Endometrium, Inflammation, Acute     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
      Hypocellularity                      |                                                                          |      2  1.5|
      Myelofibrosis                        |                                                                          |     14  1.2|
      Myeloid Cell, Hyperplasia            |                                                                          |      7  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  48        |
      Iliac, Edema                         |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
      Mediastinal, Abscess                 |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  4.0|
      Mediastinal, Inflammation, Acute     |                                                                          |      1  2.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      2  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |     14  2.0|
      Mesenteric, Hyperplasia, Plasma Cell |                                                                          |      1  2.0|
      Mesenteric, Pigmentation             |                                                                          |      4  1.0|
      Mesenteric, Lymphocyte, Necrosis     |                                                                          |      1  2.0|
      Renal, Abscess                       |                                                                          |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  18        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  21        |
      Hematopoietic Cell Proliferation     |                                                                          |      7  3.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |   7        |
      Atrophy                              |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Dermis, Inflammation, Acute          |                                                                          |      1  2.0|
      Dermis, Inflammation, Chronic        |                                                                          |     25  1.9|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  16        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  15        |
      Thalamus, Mineralization             |                                                                          |     12  1.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Alveolus, Mineralization             |                                                                          |      1  1.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  15        |
      Sinus, Exudate, Acute                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Inflammation, Chronic        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  17        |
      Infarct, Chronic                     |                                                                          |      1  2.0|
      Nephropathy                          |                                                                          |      2  2.0|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |                                                                          |      1  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Renal Tubule, Degeneration,     |                                                                          |            |
           Hyaline                         |                                                                          |      2  2.5|
      Renal Tubule, Hypertrophy            |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 6| 5| 5| 5| 6| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  15        |
      Polyarteritis                        |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 0| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 5| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 8| 4| 2| 4| 2| 2| 2| 2| 1| 2| 1| 2|             
                                           | 0| 3| 5| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 7| 4| 4| 4| 4| 4| 4| 7| 8| 5| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  A|             
      Inflammation, Chronic Active         |             2                                      2                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                               3                                          |             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Chronic                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X                                         2               |             
      Hematopoietic Cell Proliferation     |                                        1                                 |             
      Hepatocyte, Necrosis                 |                                        2        2                        |             
      Sinusoid, Dilatation                 |                                  1                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinar Cell, Atrophy                 |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          2           1                       1                           |             
      Ulcer, Focal                         |                                                                          |             
      Mucosa, Hyperplasia                  |                                                    2     2               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +     +                                   +   |             
      Incisor, Developmental Malformation  |                            3     3                                   3   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                  2     1                                 |             
      Artery, Polyarteritis, Chronic       |                               2                                          |             
      Interstitium, Fibrosis               |                                           1  2                           |             
      Myocardium, Degeneration             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 0| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 5| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 8| 4| 2| 4| 2| 2| 2| 2| 1| 2| 1| 2|             
                                           | 0| 3| 5| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 7| 4| 4| 4| 4| 4| 4| 7| 8| 5| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Clear Cell Focus                     |                         2                                         2      |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                                       1                  |             
      Hypertrophy, Focal                   |                                     1              1                     |             
      Extra Adrenal Tissue, Accessory      |                                                                          |             
          Adrenal Cortical Nodule          | X                                                                        |             
      Spindle Cell, Hyperplasia            | 1  2     2  2  1        3  2     2  2  2  1  2  1  2  2  2     1        1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hypospermia                          |                                                       4                  |             
      Inflammation, Chronic                |                                                                          |             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                       +              +              M            |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                               4              3                           |             
      Duct, Ectasia                        |                               3              4                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           | 3                                                                        |             
      Inflammation, Acute                  |       3                                                                  |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 0| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 5| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 8| 4| 2| 4| 2| 2| 2| 2| 1| 2| 1| 2|             
                                           | 0| 3| 5| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 7| 4| 4| 4| 4| 4| 4| 7| 8| 5| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         | 3                                                                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Inflammation, Chronic                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis, Chronic               |                               1                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |             1  1                                                         |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
      Seminiferous Tubule, Giant Cell      |       2                                                                 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            | 2              2                       4                             3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         | 4                                                                        |             
      Inguinal, Hyperplasia, Lymphoid      | 2                             3                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                        3                                 |             
      Mesenteric, Angiectasis              |                      1                                1                  |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                      2  1     2                 2                        |             
      Mesenteric, Hyperplasia, Lymphoid    | 2           2  1     2  1  2     2           2  2        1               |             
      Mesenteric, Inflammation, Acute      |                                                                          |             
      Mesenteric, Thrombosis               |                                                                          |             
      Mesenteric, Lymphocyte, Necrosis     |                            2           1                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Hyperplasia, Re Cell                 | 2                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2                    3                 4  2     2                    2  2|             
      Hyperplasia, Lymphoid                |          2                                                               |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Lymphocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  M  M  +  M  +|             
      Atrophy                              |                                                                         3|             
      Cyst                                 | 2                                                                        |             
      Inflammation, Acute                  |                                                                          |             
      Cortex, Necrosis                     |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parakeratosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 0| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 5| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 8| 4| 2| 4| 2| 2| 2| 2| 1| 2| 1| 2|             
                                           | 0| 3| 5| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 7| 4| 4| 4| 4| 4| 4| 7| 8| 5| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ulcer                                | 3                                                                        |             
      Dermis, Fibrosis                     |                                                                          |             
      Dermis, Inflammation, Acute          |                                                                          |             
      Dermis, Inflammation, Chronic        |          2     3        1           2           1              2  3      |             
      Epithelium, Hyperplasia              |                                                                          |             
      Prepuce, Inflammation, Chronic       |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             |    2  2  2  2  2  2  2     2  2  2  2  2  1  2     2  2  2     1     2  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                                           3            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  | 1                                                                        |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Peribronchial, Glands, Exudate       |                                                          2               |             
      Perivascular, Inflammation, Chronic  |                                  3                                       |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Purulent                    |                2              2  2                                       |             
      Foreign Body                         |                               2                                          |             
      Inflammation, Acute                  |                                                          2               |             
      Inflammation, Chronic Active         |                                                                      3   |             
      Lumen, Hemorrhage                    |                                                                          |             
      Nasolacrimal Duct, Foreign Body      |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                2                                                         |             
      Submucosa, Cyst                      |                                                 2                        |             
      Vomeronasal Organ, Exudate, Purulent |                            2                                             |             
      Vomeronasal Organ, Foreign Body      |                            2                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Phthisis Bulbi                       |                4                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 0| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 5| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 8| 4| 2| 4| 2| 2| 2| 2| 1| 2| 1| 2|             
                                           | 0| 3| 5| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 7| 4| 4| 4| 4| 4| 4| 7| 8| 5| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                    2                     |             
      Infarct, Chronic                     |                                                       3                  |             
      Inflammation, Acute                  |                                                                          |             
      Nephropathy                          |    1     1     1     2  1  1  1  2  1     3  2  3  1  2  1        2  1  1|             
      Artery, Polyarteritis, Chronic       |                               2                                          |             
      Cortex, Renal Tubule, Necrosis, Acute|                                                                          |             
      Medulla, Congestion                  |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Degeneration, Hyaline           |                                                                          |             
      Renal Tubule, Dilatation             |       2                                                                  |             
      Renal Tubule, Hypertrophy            |                                                                          |             
      Renal Tubule, Mineralization         |    1  2              1     1  1        1     2                           |             
                                            __________________________________________________________________________|             
   Urethra                                 |       +                                                                  |             
      Inflammation, Acute                  |       3                                                                  |             
      Bulbourethral Gland, Ectasia         |                                                                          |             
      Bulbourethral Gland, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 4| 6| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 2| 2| 1| 2| 2| 2| 2| 4| 2| 2| 2| 0| 2| 4| 2| 1| 4| 2| 1| 1| 3| 4| 2|             
                                           | 3| 5| 5| 5| 1| 8| 5| 8| 8| 4| 8| 9| 9| 4| 9| 4| 9| 1| 7| 9| 8| 0| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  +        +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +|             
      Inflammation, Acute                  |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                           3                              |             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                      3                                2                  |             
      Hepatocyte, Necrosis                 |                                        3                                 |             
      Sinusoid, Dilatation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinar Cell, Atrophy                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Submandibular Gland,           |                                                                          |             
          Hyperplasia                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          1        2                 1                          2     1  1|             
      Ulcer, Focal                         |          1                                                               |             
      Mucosa, Hyperplasia                  |                         2  2                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Developmental Malformation  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                                                     |             
      Aorta, Inflammation, Chronic         |    2                                                                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Artery, Polyarteritis, Chronic       |                                                                          |             
      Interstitium, Fibrosis               |    2                    2              1              2                 2|             
      Myocardium, Degeneration             |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 4| 6| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 2| 2| 1| 2| 2| 2| 2| 4| 2| 2| 2| 0| 2| 4| 2| 1| 4| 2| 1| 1| 3| 4| 2|             
                                           | 3| 5| 5| 5| 1| 8| 5| 8| 8| 4| 8| 9| 9| 4| 9| 4| 9| 1| 7| 9| 8| 0| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                          2               |             
      Cyst                                 |                                     2                                    |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |       1        2        2     1              1                    1      |             
      Extra Adrenal Tissue, Accessory      |                                                                          |             
          Adrenal Cortical Nodule          |                                                                          |             
      Spindle Cell, Hyperplasia            | 2  2  2  2  2  1  1  2  2  2  2  1  2  2  1  1  2     2     2  3  1  1  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                             1                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |                   2        3                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  M  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  M  +  M  M  +|             
      Pars Distalis, Cyst                  |                         1                                                |             
      Pars Distalis, Hyperplasia           |                               2                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         2                                                |             
      Ultimobranchial Cyst                 |                                                                2         |             
      Follicle, Cyst                       |             2                       2                 1           2      |             
      Follicular Cell, Hyperplasia         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    3                                                                     |             
      Hypospermia                          |             2                                                            |             
      Inflammation, Chronic                |    2                                                                     |             
      Spermatocele                         |                                                          4               |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                             +            |             
      Inflammation, Acute                  |                                                             3            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +              +  +        +                       +           +      |             
      Abscess                              |                      4                                                   |             
      Inflammation, Chronic                |    2              4           2                                   4      |             
      Duct, Ectasia                        |    3              4           3                       2                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                             2            |             
      Inflammation, Chronic                |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 4| 6| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 2| 2| 1| 2| 2| 2| 2| 4| 2| 2| 2| 0| 2| 4| 2| 1| 4| 2| 1| 1| 3| 4| 2|             
                                           | 3| 5| 5| 5| 1| 8| 5| 8| 8| 4| 8| 9| 9| 4| 9| 4| 9| 1| 7| 9| 8| 0| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                    3                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   | 2                                                                        |             
      Inflammation, Chronic                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis, Chronic               |                                                                          |             
      Interstitial Cell, Hyperplasia       |                      2                                                   |             
      Seminiferous Tubule, Atrophy         |             1                    1                                       |             
      Seminiferous Tubule, Degeneration    |                                        2                                 |             
      Seminiferous Tubule, Giant Cell      |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                         +                                                |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            | 4           2     2  3     3                       3  3  1     3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                      4                                                   |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Mesenteric, Angiectasis              |    2                 2              2     2  1  2                 1  3   |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    | 3  2                 3              2                 3  3     2  1  2  2|             
      Mesenteric, Hyperplasia, Lymphoid    |          2     3        2                 2              2        2      |             
      Mesenteric, Inflammation, Acute      |          1                                         2  1           1      |             
      Mesenteric, Thrombosis               |                                                       3                  |             
      Mesenteric, Lymphocyte, Necrosis     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |             3                                                            |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4  2        3     3  3     3     2     4     1  1     3     2  2         |             
      Hyperplasia, Lymphoid                |          2     2                                2                    1   |             
      Hyperplasia, Re Cell                 |                                                    2                     |             
      Lymphocyte, Necrosis                 |                                              2                    2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +|             
      Atrophy                              | 3                 2  2                 2           4                 2   |             
      Cyst                                 |    1                       2  2  1  2  2  1  2  1                 1     1|             
      Inflammation, Acute                  |                               2                                          |             
      Cortex, Necrosis                     |                                              2              3     2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parakeratosis                        |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 4| 6| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 2| 2| 1| 2| 2| 2| 2| 4| 2| 2| 2| 0| 2| 4| 2| 1| 4| 2| 1| 1| 3| 4| 2|             
                                           | 3| 5| 5| 5| 1| 8| 5| 8| 8| 4| 8| 9| 9| 4| 9| 4| 9| 1| 7| 9| 8| 0| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                        3              3  3               |             
      Dermis, Fibrosis                     |                                                                   2      |             
      Dermis, Inflammation, Acute          |                                                             4            |             
      Dermis, Inflammation, Chronic        | 2  3  1     2  1     2  1     2  1        2                 2     1      |             
      Epithelium, Hyperplasia              |                                                 3     3  2               |             
      Prepuce, Inflammation, Chronic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             | 1  2  2  1  2  1  1  1  2     3  1  1  1     1  1     1  1     2        2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                            2        3                                    |             
      Inflammation, Acute                  |                                                             1            |             
      Alveolar Epithelium, Hyperplasia     |          2                                                               |             
      Peribronchial, Glands, Exudate       |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
      Pleura, Fibrosis                     |                                                             1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Purulent                    |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute                  |                               1                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Lumen, Hemorrhage                    |                                                                   2      |             
      Nasolacrimal Duct, Foreign Body      |             1                                                            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Submucosa, Cyst                      |                                                                          |             
      Vomeronasal Organ, Exudate, Purulent |                                                                          |             
      Vomeronasal Organ, Foreign Body      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 4| 6| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 2| 2| 1| 2| 2| 2| 2| 4| 2| 2| 2| 0| 2| 4| 2| 1| 4| 2| 1| 1| 3| 4| 2|             
                                           | 3| 5| 5| 5| 1| 8| 5| 8| 8| 4| 8| 9| 9| 4| 9| 4| 9| 1| 7| 9| 8| 0| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                               1                                          |             
      Infarct, Chronic                     |                                                                          |             
      Inflammation, Acute                  |                                                    4                     |             
      Nephropathy                          |    3  1  1     2  1  2  1  1  1  2  2  1  1  1  2     1  1     3     2   |             
      Artery, Polyarteritis, Chronic       |                                                                          |             
      Cortex, Renal Tubule, Necrosis, Acute|                                        2                                 |             
      Medulla, Congestion                  |                                                                   2      |             
      Pelvis, Inflammation, Acute          |                                                    4                     |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Degeneration, Hyaline           |             3                                                            |             
      Renal Tubule, Dilatation             |                                                                   2      |             
      Renal Tubule, Hypertrophy            |                                              2                           |             
      Renal Tubule, Mineralization         |                1  2           3                             1            |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                    +        +     +      |             
      Inflammation, Acute                  |                                                             3     2      |             
      Bulbourethral Gland, Ectasia         |                                                                   3      |             
      Bulbourethral Gland, Inflammation,   |                                                                          |             
           Acute                           |                                                    3                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +|             
      Inflammation, Chronic                |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 1| 4| 3| 4| 4| 3| 3| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  40        |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  42        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  42        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      2  3.0|
      Lymphoid Tissue, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  49        |
      Basophilic Focus                     |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.0|
      Hepatocyte, Necrosis                 |                                                                          |      3  2.3|
      Sinusoid, Dilatation                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  49        |
      Acinar Cell, Atrophy                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  49        |
      Duct, Submandibular Gland,           |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  49        |
      Mineralization                       |                                                                          |      9  1.3|
      Ulcer, Focal                         |                                                                          |      1  1.0|
      Mucosa, Hyperplasia                  |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
      Incisor, Developmental Malformation  |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Inflammation, Chronic         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 1| 4| 3| 4| 4| 3| 3| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Artery, Polyarteritis, Chronic       |                                                                          |      1  2.0|
      Interstitium, Fibrosis               |                                                                          |      7  1.7|
      Myocardium, Degeneration             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  48        |
      Clear Cell Focus                     |                                                                          |      3  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Hypertrophy, Focal                   |                                                                          |      8  1.3|
      Extra Adrenal Tissue, Accessory      |                                                                          |            |
          Adrenal Cortical Nodule          |                                                                          |      1     |
      Spindle Cell, Hyperplasia            |                                                                          |     41  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  48        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  46        |
      Cyst                                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  41        |
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ultimobranchial Cyst                 |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                                                          |      4  1.8|
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  49        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hypospermia                          |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Spermatocele                         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 1| 4| 3| 4| 4| 3| 3| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   9        |
      Abscess                              |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      6  3.2|
      Duct, Ectasia                        |                                                                          |      6  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  48        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  49        |
      Depletion Cellular                   |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  49        |
      Polyarteritis, Chronic               |                                                                          |      1  1.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |                                                                          |      4  1.0|
      Seminiferous Tubule, Degeneration    |                                                                          |      1  2.0|
      Seminiferous Tubule, Giant Cell      |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
      Myeloid Cell, Hyperplasia            |                                                                          |     13  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      3  3.0|
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      1  3.0|
      Mesenteric, Angiectasis              |                                                                          |     10  1.7|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |     14  2.1|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |     16  1.9|
      Mesenteric, Inflammation, Acute      |                                                                          |      4  1.3|
      Mesenteric, Thrombosis               |                                                                          |      1  3.0|
      Mesenteric, Lymphocyte, Necrosis     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Hyperplasia, Re Cell                 |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 1| 4| 3| 4| 4| 3| 3| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Hematopoietic Cell Proliferation     |                                                                          |     20  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      5  1.8|
      Hyperplasia, Re Cell                 |                                                                          |      1  2.0|
      Lymphocyte, Necrosis                 |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  39        |
      Atrophy                              |                                                                          |      7  2.6|
      Cyst                                 |                                                                          |     12  1.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Cortex, Necrosis                     |                                                                          |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  49        |
      Parakeratosis                        |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      4  3.0|
      Dermis, Fibrosis                     |                                                                          |      1  2.0|
      Dermis, Inflammation, Acute          |                                                                          |      1  4.0|
      Dermis, Inflammation, Chronic        |                                                                          |     20  1.9|
      Epithelium, Hyperplasia              |                                                                          |      3  2.7|
      Prepuce, Inflammation, Chronic       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Thalamus, Mineralization             |                                                                          |     39  1.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  49        |
      Congestion                           |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      2  2.5|
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Peribronchial, Glands, Exudate       |                                                                          |      1  2.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  3.0|
      Pleura, Fibrosis                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 1| 4| 3| 4| 4| 3| 3| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Exudate, Purulent                    |                                                                          |      3  2.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Lumen, Hemorrhage                    |                                                                          |      1  2.0|
      Nasolacrimal Duct, Foreign Body      |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Submucosa, Cyst                      |                                                                          |      1  2.0|
      Vomeronasal Organ, Exudate, Purulent |                                                                          |      1  2.0|
      Vomeronasal Organ, Foreign Body      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Phthisis Bulbi                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  49        |
      Cyst                                 |                                                                          |      2  1.5|
      Infarct, Chronic                     |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Nephropathy                          |                                                                          |     37  1.5|
      Artery, Polyarteritis, Chronic       |                                                                          |      1  2.0|
      Cortex, Renal Tubule, Necrosis, Acute|                                                                          |      1  2.0|
      Medulla, Congestion                  |                                                                          |      1  2.0|
      Pelvis, Inflammation, Acute          |                                                                          |      1  4.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Degeneration, Hyaline           |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             |                                                                          |      2  2.0|
      Renal Tubule, Hypertrophy            |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |     11  1.5|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   4        |
      Inflammation, Acute                  |                                                                          |      3  2.7|
      Bulbourethral Gland, Ectasia         |                                                                          |      1  3.0|
      Bulbourethral Gland, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  44        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 1| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 5| 2| 5| 2| 2| 0| 2| 2| 0| 2| 7| 4| 7| 2| 2| 2| 4| 2| 2| 6| 2| 2| 2|             
                                           | 1| 3| 1| 3| 9| 3| 4| 0| 3| 4| 3| 4| 2| 8| 3| 5| 4| 4| 7| 5| 5| 9| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Epithelium, Cytoplasmic Alteration   |                                        3                                 |             
      Wall, Mucocele                       |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Lymphoid Tissue, Pigmentation        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                 3                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Lymphoid Tissue, Hyperplasia         |                   4                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                  2                       4  3            |             
      Lymphoid Tissue, Pigmentation        |                                  2     2     1  2  1                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                               2                                          |             
      Inflammation, Acute                  |                                                 2                        |             
      Inflammation, Chronic                |                                                                          |             
      Hepatocyte, Necrosis                 |                                                                      1   |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Acinar Cell, Atrophy                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperkeratosis                       | 1                                      2                                 |             
      Inflammation, Acute                  |    2              1        1                                             |             
      Epithelium, Hyperplasia              |    1              1        2           3                    2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  +  +|             
      Mineralization                       |          2        2        2  2                                          |             
      Mucosa, Granuloma                    |                                                                          |             
      Mucosa, Hyperplasia                  |          2                 3                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                             +                        |             
      Incisor, Developmental Malformation  |                   3                                                      |             
      Incisor, Inflammation, Chronic Active|                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 1| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 5| 2| 5| 2| 2| 0| 2| 2| 0| 2| 7| 4| 7| 2| 2| 2| 4| 2| 2| 6| 2| 2| 2|             
                                           | 1| 3| 1| 3| 9| 3| 4| 0| 3| 4| 3| 4| 2| 8| 3| 5| 4| 4| 7| 5| 5| 9| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                               2                                          |             
      Atrioventricular Valve, Inflammation,|                                                                          |             
           Chronic                         |                                                                          |             
      Interstitium, Fibrosis               |    1                 3  1                                1               |             
      Myocardium, Degeneration             |                      2                 2                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus, Focal              |                                                                   2      |             
      Clear Cell Focus                     |                                                                          |             
      Hematocyst                           |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                        2     2     2  1     2            |             
      Extra Adrenal Tissue, Accessory      |                                                                          |             
          Adrenal Cortical Nodule          |                                     X        X                           |             
      Spindle Cell, Hyperplasia            | 1  1           1  2     1  2     2  1  1     2  2  2  2  1  2     1  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2           2                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Ectopic Thymus                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Cyst                  |          1                       3                                       |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                  2  2                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |             +                                                            |             
      Lumen, Dilatation                    |             3                                                            |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                             2            |             
      Hemorrhage                           |                   3                                                      |             
      Hypospermia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 1| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 5| 2| 5| 2| 2| 0| 2| 2| 0| 2| 7| 4| 7| 2| 2| 2| 4| 2| 2| 6| 2| 2| 2|             
                                           | 1| 3| 1| 3| 9| 3| 4| 0| 3| 4| 3| 4| 2| 8| 3| 5| 4| 4| 7| 5| 5| 9| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                                                                      2   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                 +                    +  +                 +  +         |             
      Abscess                              |                                                                          |             
      Inflammation, Acute                  |                                        4  4                              |             
      Inflammation, Chronic                |                   2                                         3            |             
      Duct, Ectasia                        | 4                 3                    3  3                    3         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Acute                  |             2                                                            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Lumen, Dilatation                    |             3                                                            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Interstitium, Pigmentation           |                                                                      2   |             
      Seminiferous Tubule, Atrophy         |                               2                                          |             
      Seminiferous Tubule, Dilatation      |                                                             2            |             
      Seminiferous Tubule, Giant Cell      |                                                                          |             
      Seminiferous Tubule, Mineralization  |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Erythroid Cell, Hyperplasia          |                                        2                                 |             
      Myeloid Cell, Hyperplasia            |                      3              3     2                          3  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Mesenteric, Angiectasis              |          2           3  2           3  2     2                          2|             
      Mesenteric, Congestion               |                                                             2            |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                   1  2              2        2                       3  2|             
      Mesenteric, Hyperplasia, Lymphoid    |          2     2  3        2  3     2           2  2  2  2              2|             
      Mesenteric, Inflammation, Acute      | 2                                                           2        2   |             
      Mesenteric, Pigmentation             | 1  2                 1           2              1                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Lymphoid                |          2                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hematopoietic Cell Proliferation     |                      2        2     2  3                 3           4   |             
      Hyperplasia, Lymphoid                |          1                                                              1|             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Lymphocyte, Necrosis                 | 2                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M|             
      Atrophy                              |                      3        3     2                                2   |             
      Cyst                                 |                      2  2  2        1     3     1     2     2            |             
      Cortex, Necrosis                     |       3     2                                                  4         |             
      Medulla, Atrophy                     |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 1| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 5| 2| 5| 2| 2| 0| 2| 2| 0| 2| 7| 4| 7| 2| 2| 2| 4| 2| 2| 6| 2| 2| 2|             
                                           | 1| 3| 1| 3| 9| 3| 4| 0| 3| 4| 3| 4| 2| 8| 3| 5| 4| 4| 7| 5| 5| 9| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
      Acinus, Duct, Dilatation             |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                     4                                    |             
      Dermis, Fibrosis                     |                                                       2                  |             
      Dermis, Inflammation, Chronic        |    2                             1           2        2     2     2      |             
      Dermis, Mineralization               |                                                                   2      |             
      Epidermis, Hyperkeratosis            |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Arthrosis                     |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perivascular, Fibrosis, Focal        |                                                                          |             
      Thalamus, Mineralization             | 2  2     2     1  2  1  2  2     1  2  1  2     2  1  1  2     2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       3                                2                                 |             
      Hemorrhage                           |                   3  3                                                   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Exudate, Purulent                    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Nasolacrimal Duct, Exudate           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Phthisis Bulbi                       |                               4                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  2     1     1  2     1  1     1     2     1  2  1  1     1     1     1|             
      Cortex, Metaplasia, Osseous          |                                  1                                       |             
      Renal Tubule, Dilatation             |                                                       2     2            |             
      Renal Tubule, Hypertrophy            |                                                                          |             
      Renal Tubule, Mineralization         | 1           2                       1        1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 1| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7|             
                             DAY ON TEST   | 7| 2| 5| 2| 5| 2| 2| 0| 2| 2| 0| 2| 7| 4| 7| 2| 2| 2| 4| 2| 2| 6| 2| 2| 2|             
                                           | 1| 3| 1| 3| 9| 3| 4| 0| 3| 4| 3| 4| 2| 8| 3| 5| 4| 4| 7| 5| 5| 9| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |             +                                                            |             
      Inflammation, Acute                  |             2                                                            |             
      Bulbourethral Gland, Inflammation,   |                                                                          |             
           Acute                           |             2                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 3| 3| 3| 3| 3| 4| 4| 0| 3| 4| 7| 2| 7|             
                                           | 6| 8| 8| 8| 8| 9| 9| 9| 2| 9| 2| 9| 0| 0| 0| 0| 0| 8| 8| 6| 8| 2| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Epithelium, Cytoplasmic Alteration   |                                                          2               |             
      Wall, Mucocele                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoid Tissue, Pigmentation        |             1                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |       2  2                          2  2                                 |             
      Lymphoid Tissue, Pigmentation        |    2  2  1  1                                                           1|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                 2                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                    1                     |             
      Hepatocyte, Necrosis                 |                                              1                 1         |             
      Serosa, Fibrosis                     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                   +               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Acinar Cell, Atrophy                 |                            1                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperkeratosis                       |                         3                 1                       2      |             
      Inflammation, Acute                  |                                                                          |             
      Epithelium, Hyperplasia              |                                           2  2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A     +  +   |             
      Mineralization                       |       1        1           1                                             |             
      Mucosa, Granuloma                    |                                                          1               |             
      Mucosa, Hyperplasia                  |    2                                                                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                      +                           |             
      Incisor, Developmental Malformation  |       2                                      2                           |             
      Incisor, Inflammation, Chronic Active|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 3| 3| 3| 3| 3| 4| 4| 0| 3| 4| 7| 2| 7|             
                                           | 6| 8| 8| 8| 8| 9| 9| 9| 2| 9| 2| 9| 0| 0| 0| 0| 0| 8| 8| 6| 8| 2| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Atrioventricular Valve, Inflammation,|                                                                          |             
           Chronic                         |                                                                      2   |             
      Interstitium, Fibrosis               |          1  1                                      2                     |             
      Myocardium, Degeneration             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +|             
      Clear Cell Focus, Focal              |                                                                          |             
      Clear Cell Focus                     |                                  1                                       |             
      Hematocyst                           |                            2                                             |             
      Hemorrhage, Focal                    |                         2                                                |             
      Hyperplasia, Focal                   |                      2        2                                          |             
      Hypertrophy, Focal                   |             2     1                       1                          2   |             
      Extra Adrenal Tissue, Accessory      |                                                                          |             
          Adrenal Cortical Nodule          |                                                                          |             
      Spindle Cell, Hyperplasia            | 1  1  2  2  1  2  2  1  3  2  2  2  2  2  2  1  2  1  1        1  1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Cyst                                 |                                                 1                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                      2                                                   |             
      Ectopic Thymus                       |                                                                      2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |          2                                                               |             
      Pars Distalis, Hyperplasia           |                                                                      1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                   2              2                    2                  |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Lumen, Dilatation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                       3                  |             
      Hemorrhage                           |                                                                          |             
      Hypospermia                          |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 3| 3| 3| 3| 3| 4| 4| 0| 3| 4| 7| 2| 7|             
                                           | 6| 8| 8| 8| 8| 9| 9| 9| 2| 9| 2| 9| 0| 0| 0| 0| 0| 8| 8| 6| 8| 2| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                2                                                         |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +              +  +                 +  +                     |             
      Abscess                              |                                                    3                     |             
      Inflammation, Acute                  |                            2                                             |             
      Inflammation, Chronic                |             3                                      4                     |             
      Duct, Ectasia                        |             2              2                    2                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Chronic                |                               2                                          |             
      Lumen, Dilatation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitium, Pigmentation           |                                                                          |             
      Seminiferous Tubule, Atrophy         | 2  1                                               3                     |             
      Seminiferous Tubule, Dilatation      |                                                                          |             
      Seminiferous Tubule, Giant Cell      | 2                                                                        |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |    2                                                  2                  |             
      Myeloid Cell, Hyperplasia            |             1        2     2              2              3     2        1|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Angiectasis              |    2           1  2     2     2  2                                       |             
      Mesenteric, Congestion               |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                            1  1                                   1      |             
      Mesenteric, Hyperplasia, Lymphoid    |       2           2     2     2     2     2  2  2                 1  2  2|             
      Mesenteric, Inflammation, Acute      |       2           2                                2                     |             
      Mesenteric, Pigmentation             |    1  2  1  2  2        1  2  2                 1                 2     1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2  2              2  2  2  2                    3  3        4  2      |             
      Hyperplasia, Lymphoid                |                                     2     1     2                    2   |             
      Capsule, Inflammation, Chronic       |                2                                                         |             
      Lymphocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  M  +  M  M  +  M  +  +  M  M  M  +  M  +  A  +  +  M  M|             
      Atrophy                              |                                                          3     4  3      |             
      Cyst                                 |       2                                1           2           1  1      |             
      Cortex, Necrosis                     |                                                                          |             
      Medulla, Atrophy                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 3| 3| 3| 3| 3| 4| 4| 0| 3| 4| 7| 2| 7|             
                                           | 6| 8| 8| 8| 8| 9| 9| 9| 2| 9| 2| 9| 0| 0| 0| 0| 0| 8| 8| 6| 8| 2| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
      Acinus, Duct, Dilatation             |                         2                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                         2                                                |             
      Dermis, Fibrosis                     |                            2                          2                 2|             
      Dermis, Inflammation, Chronic        |    2              1     2     1     1  1                                 |             
      Dermis, Mineralization               |                         3                                                |             
      Epidermis, Hyperkeratosis            |                                                          2               |             
      Epithelium, Hyperplasia              |                                                    3  2  2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Arthrosis                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Perivascular, Fibrosis, Focal        |                            2                                             |             
      Thalamus, Mineralization             |    2  2     2     2     2  2  2        2  2  2  2  2  1           2     2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                             2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Purulent                    |                                                    1                     |             
      Inflammation, Acute                  |                   1                                                      |             
      Nasolacrimal Duct, Exudate           | 2                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 3  2  1     1  2  1  1  1     3  1  1  1  1  2  2  2  1  1        2  1  1|             
      Cortex, Metaplasia, Osseous          |                                                                          |             
      Renal Tubule, Dilatation             |                   2        2              3                              |             
      Renal Tubule, Hypertrophy            |          1                                                               |             
      Renal Tubule, Mineralization         |                1     1           1  1           1                    1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 9| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 3| 3| 3| 3| 3| 4| 4| 0| 3| 4| 7| 2| 7|             
                                           | 6| 8| 8| 8| 8| 9| 9| 9| 2| 9| 2| 9| 0| 0| 0| 0| 0| 8| 8| 6| 8| 2| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Bulbourethral Gland, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Chronic                |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 0| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 3| 8| 4| 3| 4| 4| 4| 3| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  43        |
      Epithelium, Cytoplasmic Alteration   |                                                                          |      2  2.5|
      Wall, Mucocele                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  46        |
      Lymphoid Tissue, Pigmentation        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  45        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  45        |
      Lymphoid Tissue, Hyperplasia         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  45        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      7  2.4|
      Lymphoid Tissue, Pigmentation        |                                                                          |     10  1.5|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  49        |
      Basophilic Focus                     |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Hepatocyte, Necrosis                 |                                                                          |      3  1.0|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  47        |
      Acinar Cell, Atrophy                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  48        |
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  48        |
      Hyperkeratosis                       |                                                                          |      5  1.8|
      Inflammation, Acute                  |                                                                          |      3  1.3|
      Epithelium, Hyperplasia              |                                                                          |      7  1.9|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  44        |
      Mineralization                       |                                                                          |      7  1.6|
      Mucosa, Granuloma                    |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 0| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 3| 8| 4| 3| 4| 4| 4| 3| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Hyperplasia                  |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
      Incisor, Developmental Malformation  |                                                                          |      3  2.3|
      Incisor, Inflammation, Chronic Active|                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Atrioventricular Valve, Inflammation,|                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Interstitium, Fibrosis               |                                                                          |      7  1.4|
      Myocardium, Degeneration             |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  48        |
      Clear Cell Focus, Focal              |                                                                          |      1  2.0|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Hematocyst                           |                                                                          |      1  2.0|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Hypertrophy, Focal                   |                                                                          |      9  1.7|
      Extra Adrenal Tissue, Accessory      |                                                                          |            |
          Adrenal Cortical Nodule          |                                                                          |      2     |
      Spindle Cell, Hyperplasia            |                                                                          |     41  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  48        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  47        |
      Cyst                                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  47        |
      Cyst                                 |                                                                          |      1  2.0|
      Ectopic Thymus                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  48        |
      Pars Distalis, Cyst                  |                                                                          |      3  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Follicle, Cyst                       |                                                                          |      3  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 0| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 3| 8| 4| 3| 4| 4| 4| 3| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Lumen, Dilatation                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
      Granuloma Sperm                      |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hypospermia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  11        |
      Abscess                              |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      3  3.3|
      Inflammation, Chronic                |                                                                          |      4  3.0|
      Duct, Ectasia                        |                                                                          |      8  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  48        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  48        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Lumen, Dilatation                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  49        |
      Interstitium, Pigmentation           |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |                                                                          |      4  2.0|
      Seminiferous Tubule, Dilatation      |                                                                          |      1  2.0|
      Seminiferous Tubule, Giant Cell      |                                                                          |      1  2.0|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  48        |
      Erythroid Cell, Hyperplasia          |                                                                          |      3  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |     12  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  48        |
      Mesenteric, Angiectasis              |                                                                          |     13  2.1|
      Mesenteric, Congestion               |                                                                          |      1  2.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      9  1.7|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |     22  2.0|
      Mesenteric, Inflammation, Acute      |                                                                          |      6  2.0|
      Mesenteric, Pigmentation             |                                                                          |     16  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 0| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 3| 8| 4| 3| 4| 4| 4| 3| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  47        |
      Hematopoietic Cell Proliferation     |                                                                          |     16  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      6  1.5|
      Capsule, Inflammation, Chronic       |                                                                          |      1  2.0|
      Lymphocyte, Necrosis                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  32        |
      Atrophy                              |                                                                          |      7  2.9|
      Cyst                                 |                                                                          |     13  1.7|
      Cortex, Necrosis                     |                                                                          |      3  3.0|
      Medulla, Atrophy                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |   1        |
      Acinus, Duct, Dilatation             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Ulcer                                |                                                                          |      2  3.0|
      Dermis, Fibrosis                     |                                                                          |      4  2.0|
      Dermis, Inflammation, Chronic        |                                                                          |     12  1.6|
      Dermis, Mineralization               |                                                                          |      2  2.5|
      Epidermis, Hyperkeratosis            |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Joint, Arthrosis                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  49        |
      Perivascular, Fibrosis, Focal        |                                                                          |      1  2.0|
      Thalamus, Mineralization             |                                                                          |     34  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      2  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  49        |
      Exudate, Purulent                    |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 0| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 3| 8| 4| 3| 4| 4| 4| 3| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Nasolacrimal Duct, Exudate           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Phthisis Bulbi                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Nephropathy                          |                                                                          |     37  1.4|
      Cortex, Metaplasia, Osseous          |                                                                          |      1  1.0|
      Renal Tubule, Dilatation             |                                                                          |      5  2.2|
      Renal Tubule, Hypertrophy            |                                                                          |      1  1.0|
      Renal Tubule, Mineralization         |                                                                          |     10  1.1|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Bulbourethral Gland, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  46        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 6| 6| 7| 7| 0| 0| 0|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 0| 4| 0| 2| 2| 9| 2| 8| 2| 8| 2| 1| 4| 2| 2| 8| 8| 8|             
                                           | 3| 3| 1| 3| 2| 3| 1| 5| 7| 3| 4| 3| 0| 4| 7| 0| 5| 4| 7| 8| 4| 4| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |       A     A     +  +  +  +        +     +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoid Tissue, Pigmentation        |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                             2            |             
      Lymphoid Tissue, Hyperplasia         |          2                                                               |             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Chronic                          |          2                                                               |             
      Lymphoid Tissue, Pigmentation        |             2  1                 1     1  1                    2         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                               X                                          |             
      Hematopoietic Cell Proliferation     |    2                                2                                    |             
      Hepatocyte, Necrosis                 |                   2                                               2  2  2|             
      Hepatocyte, Vacuolization Cytoplasmic|                                                 2                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Congestion                      |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Inflammation, Chronic                |          4                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +     M  +  +  +        +     +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |       2           2                             2                        |             
      Inflammation, Acute                  |                                                 2                        |             
      Ulcer                                |                                                 1                        |             
      Epithelium, Hyperplasia              |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       | 2        1                                                               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                              +                           |             
      Incisor, Developmental Malformation  |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                 +                        |             
      Carotid Artery, Aneurysm             |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 6| 6| 7| 7| 0| 0| 0|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 0| 4| 0| 2| 2| 9| 2| 8| 2| 8| 2| 1| 4| 2| 2| 8| 8| 8|             
                                           | 3| 3| 1| 3| 2| 3| 1| 5| 7| 3| 4| 3| 0| 4| 7| 0| 5| 4| 7| 8| 4| 4| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Interstitium, Fibrosis               |                                                                          |             
      Myocardium, Degeneration             |                         1                       2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Hyperplasia, Focal                   |                                           2                              |             
      Hypertrophy, Focal                   |       2              2                                   1               |             
      Necrosis                             |                                                 4                        |             
      Spindle Cell, Hyperplasia            |       2     1        2  1  1        2     1  2           1              1|             
      Unilateral, Atrophy                  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Hyperplasia, Focal                   |                            1                                             |             
      Unilateral, Necrosis                 |                                                 4                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +     +     +  M  +  +        +     M  M  +     +  +        +  +  +|             
      Cyst                                 |             1                                                            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +     +  +  +  +        +     +  M  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Follicular Cell, Hyperplasia         |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Unilateral, Necrosis                 |                                                 3                        |             
                                            __________________________________________________________________________|             
   Penis                                   |                      +                                                   |             
      Inflammation, Acute                  |                      3                                                   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +                    +                          +         |             
      Abscess                              |                                                                          |             
      Duct, Ectasia                        |                4                                               3         |             
                                            __________________________________________________________________________|             
   Prostate                                |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Depletion Cellular                   |    2                                                                     |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Polyarteritis, Chronic               |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 6| 6| 7| 7| 0| 0| 0|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 0| 4| 0| 2| 2| 9| 2| 8| 2| 8| 2| 1| 4| 2| 2| 8| 8| 8|             
                                           | 3| 3| 1| 3| 2| 3| 1| 5| 7| 3| 4| 3| 0| 4| 7| 0| 5| 4| 7| 8| 4| 4| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
      Seminiferous Tubule, Giant Cell      |                   1                                                      |             
      Unilateral, Necrosis                 |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Myeloid Cell, Hyperplasia            |                         3                 2                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Inguinal, Lymphocyte, Necrosis       |                                                                   3      |             
      Mesenteric, Angiectasis              |                            1                             2               |             
      Mesenteric, Congestion               |                      3                                                   |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |    1           1           1        2                    2               |             
      Mesenteric, Hyperplasia, Lymphoid    |                1        2     2  2     1                    2            |             
      Mesenteric, Inflammation, Acute      |    2                                                                     |             
      Mesenteric, Inflammation, Chronic    |          4                                                               |             
      Mesenteric, Pigmentation             |                               1  2     1     1  3              2         |             
      Mesenteric, Lymphocyte, Necrosis     |                                                                   3  1  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +     +     M  +  +  +        +     +  +  +     +  +        +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                           2                              |             
      Lymphocyte, Necrosis                 |                                                                      1   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Angiectasis                          |                                                       2                  |             
      Hematopoietic Cell Proliferation     |    3                    3  3              4     3     3  2               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphocyte, Necrosis                 |                                                                      2  1|             
                                            __________________________________________________________________________|             
   Thymus                                  |       M     +     +  +  +  M        +     M  +  +     +  +        +  +  M|             
      Atrophy                              |                                                                      3   |             
      Cyst                                 |                         1           1           1                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       M     M     M  M  M  M        M     M  M  M     M  M        M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                      3                    4                              |             
      Dermis, Inflammation, Chronic        |       2                    2  2  2                 2     2               |             
      Epithelium, Hyperplasia              |                                                                          |             
      Prepuce, Inflammation, Chronic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 6| 6| 7| 7| 0| 0| 0|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 0| 4| 0| 2| 2| 9| 2| 8| 2| 8| 2| 1| 4| 2| 2| 8| 8| 8|             
                                           | 3| 3| 1| 3| 2| 3| 1| 5| 7| 3| 4| 3| 0| 4| 7| 0| 5| 4| 7| 8| 4| 4| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Thalamus, Mineralization             |       2                 1                 2  1  2                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      3                          3                        |             
      Peribronchiolar, Cyst                |                                        2                                 |             
      Pleura, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Exudate, Purulent                    |                                              3                           |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Infarct, Chronic                     |                                                 4     1                  |             
      Nephropathy                          |                   1     1  1        1     1              3        3  2  2|             
      Cortex, Metaplasia, Osseous          |                                                                          |             
      Medulla, Congestion                  |                                                                      3  2|             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Mineralization         |                                              1                           |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Bulbourethral Gland, Ectasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       M     +     +  +  +  +        +     +  +  +     +  +        +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 8| 1| 2| 2| 2| 1| 3| 3|             
                                           | 9| 5| 2| 5| 8| 5| 8| 8| 5| 5| 9| 9| 8| 8| 8| 9| 7| 3| 9| 9| 9| 9| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +     +                 +                 +  +  +           +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M     +     +                 +                 +  +  +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Pigmentation        |                                                                      1   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                      2  2        2        3  2                       2   |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Lymphoid Tissue, Pigmentation        |       1           1                 1     1  1              2        1  1|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatocyte, Necrosis                 |                                                 2     2                  |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +     +     +                              |             
      Fat, Congestion                      |                                     2                                    |             
      Fat, Necrosis                        |                               3           2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +     +                 +                 +  +  +           +      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +     +                 +                 +  +  +           +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                  1                                       |             
      Inflammation, Chronic                |                   2     1                                                |             
      Mineralization                       |          1                                      2                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Developmental Malformation  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Carotid Artery, Aneurysm             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 8| 1| 2| 2| 2| 1| 3| 3|             
                                           | 9| 5| 2| 5| 8| 5| 8| 8| 5| 5| 9| 9| 8| 8| 8| 9| 7| 3| 9| 9| 9| 9| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +     +                 +                 +  +  +           +      |             
      Interstitium, Fibrosis               |             1                 1                                          |             
      Myocardium, Degeneration             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +     +                 +                 +  +  +           +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +     +                 +                 +  +  +           +      |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |             2                                                            |             
      Necrosis                             |                                                                          |             
      Spindle Cell, Hyperplasia            | 2           1                 1                       1           1      |             
      Unilateral, Atrophy                  |                                                    4                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +     +                 +                 +  +  +           +      |             
      Hyperplasia, Focal                   |                                                                          |             
      Unilateral, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +     +                 +                 +  +  +           +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +     +                 +                 +  +  +           +      |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +     +                 +                 +  +  +           +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +     +                 +                 +  +  +           +      |             
      Inflammation, Acute                  |                                                                   1      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +     +                 +                 +  +  +           +      |             
      Inflammation, Chronic                | 1                             1                                          |             
      Unilateral, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +     +  +           +                    +        +      |             
      Abscess                              |                                     4                                    |             
      Duct, Ectasia                        |                4     3  4                                2        2      |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +     +                 +                 +  +  +           +      |             
      Inflammation, Acute                  | 3                                                                        |             
      Inflammation, Chronic                |                               1                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +     +                 +  +              +  +  +           +      |             
      Depletion Cellular                   |                                                                          |             
      Inflammation, Acute                  | 2                                                                        |             
      Inflammation, Chronic                |                                  4                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +     +                 +                 +  +  +           +      |             
      Polyarteritis, Chronic               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 8| 1| 2| 2| 2| 1| 3| 3|             
                                           | 9| 5| 2| 5| 8| 5| 8| 8| 5| 5| 9| 9| 8| 8| 8| 9| 7| 3| 9| 9| 9| 9| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Seminiferous Tubule, Atrophy         |             1                                      1                     |             
      Seminiferous Tubule, Giant Cell      |                                                                          |             
      Unilateral, Necrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +     +                 +                    +  +           +      |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Plasma Cell      | 2                                                                        |             
      Inguinal, Lymphocyte, Necrosis       | 2                                                                        |             
      Mesenteric, Angiectasis              |    2                             1  1  3                 2        2  2   |             
      Mesenteric, Congestion               |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                            1           2                          1      |             
      Mesenteric, Hyperplasia, Lymphoid    |          2        2  2                    2     2        1  2  2  1     2|             
      Mesenteric, Inflammation, Acute      |                                                                          |             
      Mesenteric, Inflammation, Chronic    |                                                                          |             
      Mesenteric, Pigmentation             | 1  1              1           2     1                          1     1  1|             
      Mesenteric, Lymphocyte, Necrosis     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +     +                 +                 +  +  M           +      |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
      Pigmentation                         |                                                                          |             
      Lymphocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +                 +     +           +  +  +           +  +   |             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     | 2           3                                   4  3  3              3   |             
      Hyperplasia, Lymphoid                |                               2     2                             1      |             
      Lymphocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     M     +                 M                 M  M  +           M      |             
      Atrophy                              | 2                                                     1                  |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M     M                 M                 M  M  M           M      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                   3      |             
      Dermis, Inflammation, Chronic        | 1           2        2                             2  1           2     1|             
      Epithelium, Hyperplasia              |                            3           2                                 |             
      Prepuce, Inflammation, Chronic       | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +     +                 +                 +  +  +           +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 5| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 8| 1| 2| 2| 2| 1| 3| 3|             
                                           | 9| 5| 2| 5| 8| 5| 8| 8| 5| 5| 9| 9| 8| 8| 8| 9| 7| 3| 9| 9| 9| 9| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +     +                 +                 +  +  +           +      |             
      Thalamus, Mineralization             |             2                 1                 2                 1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 1                                                                        |             
      Peribronchiolar, Cyst                |                                                                          |             
      Pleura, Inflammation, Chronic        |                                                                         1|             
                                            __________________________________________________________________________|             
   Nose                                    | +     +     +                 +                 +  +  +           +      |             
      Exudate, Purulent                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +     +                 +                 +  +  +           +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +     +                 +                 +  +  +           +      |             
      Infarct, Chronic                     |                                                       2                  |             
      Nephropathy                          |                               1                    2              1      |             
      Cortex, Metaplasia, Osseous          |             1                                                            |             
      Medulla, Congestion                  |                                                                          |             
      Renal Tubule, Dilatation             | 3                                                                        |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                      +                                                   |             
      Bulbourethral Gland, Ectasia         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     +                 +                 +  +  +           +      |             
      Inflammation, Chronic                | 2                                                                        |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 3| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 9| 6| 6| 0| 6| 6| 6| 6|                                            |            |
                                           | 3| 3| 3| 3| 4| 7| 3| 3| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  47        |
      Lymphoid Tissue, Pigmentation        |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  47        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      7  2.1|
      Lymphoid Tissue, Hyperplasia         |                                                                          |      1  2.0|
      Lymphoid Tissue, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
      Lymphoid Tissue, Pigmentation        |                                                                          |     14  1.2|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Clear Cell Focus                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hepatocyte, Necrosis                 |                                                                          |      6  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Congestion                      |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  25        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Hyperkeratosis                       |                                                                          |      3  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Mineralization                       |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 3| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 9| 6| 6| 0| 6| 6| 6| 6|                                            |            |
                                           | 3| 3| 3| 3| 4| 7| 3| 3| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Incisor, Developmental Malformation  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Carotid Artery, Aneurysm             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  23        |
      Interstitium, Fibrosis               |                                                                          |      2  1.0|
      Myocardium, Degeneration             |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  23        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      4  1.8|
      Necrosis                             |                                                                          |      1  4.0|
      Spindle Cell, Hyperplasia            |                                                                          |     15  1.3|
      Unilateral, Atrophy                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  23        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Unilateral, Necrosis                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  20        |
      Cyst                                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  23        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  23        |
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Unilateral, Necrosis                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   9        |
      Abscess                              |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 3| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 9| 6| 6| 0| 6| 6| 6| 6|                                            |            |
                                           | 3| 3| 3| 3| 4| 7| 3| 3| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Duct, Ectasia                        |                                                                          |      7  3.1|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  23        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  25        |
      Depletion Cellular                   |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  23        |
      Polyarteritis, Chronic               |                                                                          |      1  1.0|
      Seminiferous Tubule, Atrophy         |                                                                          |      2  1.0|
      Seminiferous Tubule, Giant Cell      |                                                                          |      1  1.0|
      Unilateral, Necrosis                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  22        |
      Myeloid Cell, Hyperplasia            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  2.0|
      Inguinal, Lymphocyte, Necrosis       |                                                                          |      2  2.5|
      Mesenteric, Angiectasis              |                                                                          |      9  1.8|
      Mesenteric, Congestion               |                                                                          |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      8  1.4|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |     16  1.8|
      Mesenteric, Inflammation, Acute      |                                                                          |      1  2.0|
      Mesenteric, Inflammation, Chronic    |                                                                          |      1  4.0|
      Mesenteric, Pigmentation             |                                                                          |     14  1.4|
      Mesenteric, Lymphocyte, Necrosis     |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  21        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Lymphocyte, Necrosis                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  26        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |     13  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  1.7|
      Lymphocyte, Necrosis                 |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  14        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 3| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 9| 6| 6| 0| 6| 6| 6| 6|                                            |            |
                                           | 3| 3| 3| 3| 4| 7| 3| 3| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      3  2.0|
      Cyst                                 |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  48        |
      Ulcer                                |                                                                          |      3  3.3|
      Dermis, Inflammation, Chronic        |                                                                          |     13  1.8|
      Epithelium, Hyperplasia              |                                                                          |      2  2.5|
      Prepuce, Inflammation, Chronic       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  23        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  23        |
      Thalamus, Mineralization             |                                                                          |      9  1.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      3  2.3|
      Peribronchiolar, Cyst                |                                                                          |      1  2.0|
      Pleura, Inflammation, Chronic        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  23        |
      Exudate, Purulent                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  23        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  23        |
      Infarct, Chronic                     |                                                                          |      3  2.3|
      Nephropathy                          |                                                                          |     12  1.6|
      Cortex, Metaplasia, Osseous          |                                                                          |      1  1.0|
      Medulla, Congestion                  |                                                                          |      2  2.5|
      Renal Tubule, Dilatation             |                                                                          |      1  3.0|
      Renal Tubule, Mineralization         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 3| 4| 4| 2| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 9| 6| 6| 0| 6| 6| 6| 6|                                            |            |
                                           | 3| 3| 3| 3| 4| 7| 3| 3| 3| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bulbourethral Gland, Ectasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  22        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 7| 7| 0| 1| 7| 7| 7| 6| 4| 7| 5| 5| 4| 6| 7| 7| 6| 0| 1| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 2| 2| 2| 3| 6| 2| 2| 2| 1| 3| 2| 2| 9| 7| 8| 2| 2| 4| 7| 2| 2| 2| 2|             
                                           | 7| 8| 3| 1| 3| 5| 8| 3| 3| 3| 7| 6| 4| 4| 8| 2| 7| 2| 4| 7| 3| 2| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +     +     +  +           +  M     +  +  +  M  A     +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +|             
      Inflammation, Chronic                |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  M  A  +  +  +  +  M  +  +  +  +  +  M  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  M  A  +  +  +  +  M  +  +  +  +  +  A  +  +  +  A  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
      Lymphoid Tissue, Pigmentation        |                         1  1        2                 2                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                           2  2                           |             
      Inflammation, Chronic                |                                                                          |             
      Hepatocyte, Necrosis                 |                   1           1                             1            |             
      Sinusoid, Dilatation                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +     +  +           +  +     +  +  +  +  +     +  +  A         |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Infiltration Cellular, Mast Cell     |                                                                         2|             
      Epithelium, Hyperplasia              |             1                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                       1                  |             
      Mineralization                       |    1                          2     1                    1               |             
      Mucosa, Hyperplasia                  |             2                                                            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                          +               |             
      Incisor, Developmental Malformation  |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
      Inflammation, Acute                  |                                                                          |             
      Atrium, Thrombosis                   |          3                                                               |             
      Endocardium, Inflammation, Acute     |                                                                          |             
      Interstitium, Fibrosis               |                                                 1                        |             
      Myocardium, Degeneration             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 7| 7| 0| 1| 7| 7| 7| 6| 4| 7| 5| 5| 4| 6| 7| 7| 6| 0| 1| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 2| 2| 2| 3| 6| 2| 2| 2| 1| 3| 2| 2| 9| 7| 8| 2| 2| 4| 7| 2| 2| 2| 2|             
                                           | 7| 8| 3| 1| 3| 5| 8| 3| 3| 3| 7| 6| 4| 4| 8| 2| 7| 2| 4| 7| 3| 2| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
      Hypertrophy, Focal                   |                                                          1               |             
      Spindle Cell, Hyperplasia            |    2     1        1           1        1  1     1  1     2  1            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +     +  +           +  +     +  +  +  +  +     +  M  A         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +     +  M           +  +     +  +  +  +  +     +  M  M         |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    M     +     +  +           +  M     +  +  +  +  +     +  +  +         |             
      Pars Distalis, Congestion            |                3                                                         |             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +     +  +           +  +     +  +  +  +  +     +  M  M         |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                                                     |             
      Cyst                                 |    2                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                            +                                            +|             
      Abscess                              |                                                                         3|             
      Inflammation, Chronic                |                                                                          |             
      Duct, Ectasia                        |                            2                                            2|             
                                            __________________________________________________________________________|             
   Prostate                                |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
      Inflammation, Acute                  |    3              3                                            3         |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
      Depletion Cellular                   |                                                                          |             
      Inflammation, Acute                  |                   2                                            2         |             
      Inflammation, Chronic                | 2  2                                                                     |             
                                            __________________________________________________________________________|             
   Testes                                  |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +     +  +           +  +     +  +  A  +  +     +  +  +         |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Autolysis                  |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 7| 7| 0| 1| 7| 7| 7| 6| 4| 7| 5| 5| 4| 6| 7| 7| 6| 0| 1| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 2| 2| 2| 3| 6| 2| 2| 2| 1| 3| 2| 2| 9| 7| 8| 2| 2| 4| 7| 2| 2| 2| 2|             
                                           | 7| 8| 3| 1| 3| 5| 8| 3| 3| 3| 7| 6| 4| 4| 8| 2| 7| 2| 4| 7| 3| 2| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                                              3                           |             
      Inguinal, Hyperplasia, Plasma Cell   |                                              2                           |             
      Inguinal, Lymphocyte, Necrosis       |                                                             2            |             
      Mesenteric, Angiectasis              |                                                       2                 2|             
      Mesenteric, Autolysis                |                                                    4           4         |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                      2                       3  2     1  1               |             
      Mesenteric, Hyperplasia, Lymphoid    |                         2  2                          1  2              1|             
      Mesenteric, Inflammation, Acute      |                                              2                       2  1|             
      Mesenteric, Pigmentation             |             1        2        2                          1               |             
      Mesenteric, Thrombosis               |                                                          2           3   |             
      Mesenteric, Lymphocyte, Necrosis     |                                                                          |             
      Renal, Lymphocyte, Hyperplasia       |                   3                                                      |             
      Renal, Lymphocyte, Necrosis          |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +     +  M           +  M     +  +  +  +  +     +  +  +         |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +     +  +           +  +     +  +  +  +  +     +  +  M         |             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |          2                    2        3  3  4  2        3               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphocyte, Depletion Cellular       |                2                                                         |             
      Lymphocyte, Necrosis                 |                   2                                                      |             
      Red Pulp, Depletion Cellular         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M     M     +  +           M  M     M  M  M  M  M     +  +  +         |             
      Atrophy                              |                2                                         3  3            |             
      Cyst                                 |                                                          2               |             
      Cortex, Necrosis                     |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M     M     M  M           M  M     M  M  M  M  M     M  M  M         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                2                                4     3                  |             
      Dermis, Inflammation, Chronic        |                2           2  2  2     2  1  2                    1     2|             
      Dermis, Mineralization               |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
      Thalamus, Mineralization             |          2                       1     1  2        3     1               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 7| 7| 7| 0| 1| 7| 7| 7| 6| 4| 7| 5| 5| 4| 6| 7| 7| 6| 0| 1| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 2| 2| 2| 3| 6| 2| 2| 2| 1| 3| 2| 2| 9| 7| 8| 2| 2| 4| 7| 2| 2| 2| 2|             
                                           | 7| 8| 3| 1| 3| 5| 8| 3| 3| 3| 7| 6| 4| 4| 8| 2| 7| 2| 4| 7| 3| 2| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                2         |             
      Inflammation, Acute                  |                   2                                2                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +     +  +           +  +     +  +  +  +  +     +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +     +  +  +        +  +     +  +  +  +  +     +  +  +         |             
      Cyst                                 |                                                                          |             
      Infarct, Chronic                     |                                                                          |             
      Nephropathy                          |                      3                    1     1                        |             
      Medulla, Congestion                  |                   2                                                      |             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Dilatation             |                                                             1            |             
      Renal Tubule, Hypertrophy            |                                                                          |             
      Renal Tubule, Mineralization         |    2                                      1        1                     |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +     +  +           +  +     +  +  +  +  +     +  +  A         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 7| 5| 6| 7| 7| 1| 1| 4| 4| 6| 7| 7| 6| 7| 7| 0| 0| 5| 7| 7|             
                             DAY ON TEST   | 2| 1| 8| 2| 4| 2| 8| 0| 2| 2| 1| 2| 2| 2| 7| 2| 2| 4| 2| 2| 8| 7| 1| 2| 2|             
                                           | 5| 9| 0| 5| 4| 2| 1| 3| 5| 1| 5| 5| 1| 2| 3| 8| 5| 8| 5| 2| 7| 9| 5| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    A  A     +  +  +  +     +  A  +  A  +  +        +     A  A  +  A     A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  A|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  A|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  A|             
      Inflammation, Acute                  |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  A  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  A  A  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  A  +  A|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                         2                    3                           |             
      Lymphoid Tissue, Pigmentation        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      2        2  2  2              2                     |             
      Inflammation, Chronic                |                      2                       1                           |             
      Hepatocyte, Necrosis                 |                   1        1        2                          1  2      |             
      Sinusoid, Dilatation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
      Inflammation, Chronic                |                                                                1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
      Hyperkeratosis                       |                1                                                         |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |       1              1                    2                              |             
      Mucosa, Hyperplasia                  |                         2                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                                            +               |             
      Incisor, Developmental Malformation  |             3                                            1               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
      Inflammation, Acute                  |                               2  4                                       |             
      Atrium, Thrombosis                   |                                                                          |             
      Endocardium, Inflammation, Acute     |                                                                2         |             
      Interstitium, Fibrosis               |                                     2                                   1|             
      Myocardium, Degeneration             |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 7| 5| 6| 7| 7| 1| 1| 4| 4| 6| 7| 7| 6| 7| 7| 0| 0| 5| 7| 7|             
                             DAY ON TEST   | 2| 1| 8| 2| 4| 2| 8| 0| 2| 2| 1| 2| 2| 2| 7| 2| 2| 4| 2| 2| 8| 7| 1| 2| 2|             
                                           | 5| 9| 0| 5| 4| 2| 1| 3| 5| 1| 5| 5| 1| 2| 3| 8| 5| 8| 5| 2| 7| 9| 5| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Mineralization           |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
      Hypertrophy, Focal                   |                                           1                              |             
      Spindle Cell, Hyperplasia            |                2  1  2              1  2  1        1     1  1     1     1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
      Hyperplasia                          |                                                    1                    3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     +  M  +  +     +  +  +  +  +  +        +     +  +  M  M     +|             
      Cyst                                 |                                        2                    1            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    M  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
      Pars Distalis, Congestion            |                                                                          |             
      Pars Distalis, Cyst                  |                                           1                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
      Ultimobranchial Cyst                 |                                                          2               |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                          +  +           +                     |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |          4                             3           4                     |             
      Duct, Ectasia                        |                                     2  4                                 |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
      Inflammation, Acute                  |                                        1                    2            |             
      Inflammation, Chronic                |                                  3                             1         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +     +  +  +  +     +  +  M  +  +  +        +     +  +  +  +     +|             
      Depletion Cellular                   |                                                    3                     |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
      Myeloid Cell, Hyperplasia            |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Autolysis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 7| 5| 6| 7| 7| 1| 1| 4| 4| 6| 7| 7| 6| 7| 7| 0| 0| 5| 7| 7|             
                             DAY ON TEST   | 2| 1| 8| 2| 4| 2| 8| 0| 2| 2| 1| 2| 2| 2| 7| 2| 2| 4| 2| 2| 8| 7| 1| 2| 2|             
                                           | 5| 9| 0| 5| 4| 2| 1| 3| 5| 1| 5| 5| 1| 2| 3| 8| 5| 8| 5| 2| 7| 9| 5| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                     2                                    |             
      Inguinal, Lymphocyte, Necrosis       |                                                                1         |             
      Mesenteric, Angiectasis              |                      2  1  3                       2  1                 3|             
      Mesenteric, Autolysis                |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                      2     2                    1  2                 1   |             
      Mesenteric, Hyperplasia, Lymphoid    |          2  1  2                             3                       2   |             
      Mesenteric, Inflammation, Acute      |                                                                   2      |             
      Mesenteric, Pigmentation             | 1           1                 1           1                              |             
      Mesenteric, Thrombosis               |                                                                          |             
      Mesenteric, Lymphocyte, Necrosis     |                                        1                       2         |             
      Renal, Lymphocyte, Hyperplasia       |                                                                          |             
      Renal, Lymphocyte, Necrosis          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    M  +     +  +  +  +     +  +  M  +  +  +        +     +  +  +  M     +|             
      Hyperplasia, Lymphoid                |             1                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
      Angiectasis                          |                                                          2               |             
      Hematopoietic Cell Proliferation     |                   2  3     2  4  4  3              3              2      |             
      Hyperplasia, Lymphoid                |    2        1                                                            |             
      Lymphocyte, Depletion Cellular       |                                                                          |             
      Lymphocyte, Necrosis                 |                                        2                    2            |             
      Red Pulp, Depletion Cellular         |                2                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     +  +  M  M     +  +  +  M  +  +        M     +  +  M  +     +|             
      Atrophy                              |    2           2           2                             3  3     3     2|             
      Cyst                                 |             1                                                            |             
      Cortex, Necrosis                     |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M     M  M  M  M     M  M  M  M  M  M        M     M  M  M  M     A|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                            3                                             |             
      Dermis, Inflammation, Chronic        |          1  2  2                 2                 2  2              2   |             
      Dermis, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
      Thalamus, Mineralization             |       2        2     2     2           2           1     3              3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 6| 7| 5| 6| 7| 7| 1| 1| 4| 4| 6| 7| 7| 6| 7| 7| 0| 0| 5| 7| 7|             
                             DAY ON TEST   | 2| 1| 8| 2| 4| 2| 8| 0| 2| 2| 1| 2| 2| 2| 7| 2| 2| 4| 2| 2| 8| 7| 1| 2| 2|             
                                           | 5| 9| 0| 5| 4| 2| 1| 3| 5| 1| 5| 5| 1| 2| 3| 8| 5| 8| 5| 2| 7| 9| 5| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Congestion                           |                                  3                          2            |             
      Inflammation, Acute                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +  +  +  +     +  +  +  +  +  +        +     +  +  +  +     +|             
      Cyst                                 |                2                                                         |             
      Infarct, Chronic                     |                                        2           2                     |             
      Nephropathy                          |    3        1  3           1  2  2  3              1                    1|             
      Medulla, Congestion                  |                                                                          |             
      Papilla, Necrosis                    |                                                             3            |             
      Pelvis, Inflammation, Acute          |                               2  3                                       |             
      Renal Tubule, Dilatation             |                                        3                                 |             
      Renal Tubule, Hypertrophy            |                                           1                              |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                        +                                 |             
      Calculus Micro Observation Only      |                                        4                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    A  +     +  +  +  +     +     +  +  +  +        +     +  +  +  +     A|             
      Inflammation, Acute                  |                                                             2            |             
      Inflammation, Chronic                |                                  2                                       |             
      Transitional Epithelium, Hyperplasia |                                  2                          2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 4| 4| 4| 4| 0| 1| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 5| 6| 6| 6| 6| 8| 8| 6|                                            |            |
                                           | 3| 3| 8| 4| 4| 4| 4| 5| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  32        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  42        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  42        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  41        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  36        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  37        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      2  2.5|
      Lymphoid Tissue, Pigmentation        |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      7  2.0|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Hepatocyte, Necrosis                 |                                                                          |      8  1.3|
      Sinusoid, Dilatation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  31        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  32        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  48        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  48        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      7  1.3|
      Mucosa, Hyperplasia                  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
      Incisor, Developmental Malformation  |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  32        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 109                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 4| 4| 4| 4| 0| 1| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 5| 6| 6| 6| 6| 8| 8| 6|                                            |            |
                                           | 3| 3| 8| 4| 4| 4| 4| 5| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
      Endocardium, Inflammation, Acute     |                                                                          |      1  2.0|
      Interstitium, Fibrosis               |                                                                          |      3  1.3|
      Myocardium, Degeneration             |                                                                          |      1  1.0|
      Myocardium, Mineralization           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  32        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  32        |
      Hypertrophy, Focal                   |                                                                          |      2  1.0|
      Spindle Cell, Hyperplasia            |                                                                          |     21  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  32        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  26        |
      Cyst                                 |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  29        |
      Pars Distalis, Congestion            |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  30        |
      Ultimobranchial Cyst                 |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  32        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   6        |
      Abscess                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      3  3.7|
      Duct, Ectasia                        |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  32        |
      Inflammation, Acute                  |                                                                          |      5  2.4|
      Inflammation, Chronic                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  32        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 110                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 4| 4| 4| 4| 0| 1| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 5| 6| 6| 6| 6| 8| 8| 6|                                            |            |
                                           | 3| 3| 8| 4| 4| 4| 4| 5| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Depletion Cellular                   |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  32        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  31        |
      Myeloid Cell, Hyperplasia            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Inguinal, Autolysis                  |                                                                          |      1  4.0|
      Inguinal, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      2  2.0|
      Inguinal, Lymphocyte, Necrosis       |                                                                          |      2  1.5|
      Mesenteric, Angiectasis              |                                                                          |      8  2.0|
      Mesenteric, Autolysis                |                                                                          |      2  4.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |     10  1.7|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |     10  1.8|
      Mesenteric, Inflammation, Acute      |                                                                          |      4  1.8|
      Mesenteric, Pigmentation             |                                                                          |      8  1.3|
      Mesenteric, Thrombosis               |                                                                          |      2  2.5|
      Mesenteric, Lymphocyte, Necrosis     |                                                                          |      2  1.5|
      Renal, Lymphocyte, Hyperplasia       |                                                                          |      1  3.0|
      Renal, Lymphocyte, Necrosis          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  27        |
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  31        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |     15  2.8|
      Hyperplasia, Lymphoid                |                                                                          |      2  1.5|
      Lymphocyte, Depletion Cellular       |                                                                          |      1  2.0|
      Lymphocyte, Necrosis                 |                                                                          |      3  2.0|
      Red Pulp, Depletion Cellular         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  18        |
      Atrophy                              |                                                                          |     10  2.5|
      Cyst                                 |                                                                          |      2  1.5|
      Cortex, Necrosis                     |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 111                                                               
NTP Experiment-Test: 05021-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:50:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 4| 4| 4| 4| 0| 1| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 5| 6| 6| 6| 6| 8| 8| 6|                                            |            |
                                           | 3| 3| 8| 4| 4| 4| 4| 5| 9| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Ulcer                                |                                                                          |      4  3.0|
      Dermis, Inflammation, Chronic        |                                                                          |     16  1.8|
      Dermis, Mineralization               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  32        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  32        |
      Thalamus, Mineralization             |                                                                          |     14  1.9|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  49        |
      Congestion