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TDMS Study 05021-03 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         CI PIGMENT RED 23


NTP Experiment-Test: 05021-03                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: DOSED FEED                                                                                                 Time: 21:10:48




       Facility:  Southern Research Institute

       Chemical CAS #:  6471-49-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          18           11           14            8                                     
    Dead                                               3            5            3            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           34           33           40                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)                                   (50)                                   
      Autolysis                                        2 (4%)                                 2 (4%)                                
   Intestine Large, Colon                             (50)                      (1)          (50)                                   
      Autolysis                                        1 (2%)                                 2 (4%)                                
      Parasite Metazoan                                6 (12%)                                1 (2%)                                
   Intestine Large, Rectum                            (50)                                   (50)                                   
      Autolysis                                                                               2 (4%)                                
      Parasite Metazoan                               12 (24%)                                8 (16%)                               
   Intestine Small, Duodenum                          (50)                                   (50)                                   
      Autolysis                                        1 (2%)                                 2 (4%)                                
      Inflammation, Acute                              1 (2%)                                                                       
   Intestine Small, Ileum                             (50)         (15)         (24)         (50)                                   
      Autolysis                                        1 (2%)                                 2 (4%)                                
      Hyperplasia, Lymphoid                           10 (20%)     14 (93%)     24 (100%)    26 (52%)                               
      Inflammation                                                  1 (7%)                                                          
      Pigmentation                                                  1 (7%)       6 (25%)     10 (20%)                               
   Intestine Small, Jejunum                           (50)         (6)          (4)          (50)                                   
      Autolysis                                        2 (4%)                                 2 (4%)                                
      Hyperplasia, Lymphoid                                         5 (83%)      3 (75%)      4 (8%)                                
      Necrosis, Focal                                                                         1 (2%)                                
      Pigmentation                                                  1 (17%)      2 (50%)      2 (4%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus, Multiple                      34 (68%)     35 (70%)     37 (74%)     43 (86%)                               
      Bile Stasis                                      1 (2%)                                                                       
      Clear Cell Focus                                 2 (4%)       3 (6%)                    1 (2%)                                
      Congestion                                       2 (4%)                                                                       
      Ectasia                                                                    1 (2%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                       7 (14%)      8 (16%)      8 (16%)      9 (18%)                               
      Hyperplasia                                      3 (6%)       4 (8%)                    2 (4%)                                
      Hypertrophy, Focal                               1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                1 (2%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Acute                              1 (2%)       1 (2%)                    2 (4%)                                
      Inflammation, Chronic                            1 (2%)                    2 (4%)       1 (2%)                                
      Inflammation, Granulomatous                     14 (28%)     13 (26%)     11 (22%)     16 (32%)                               
      Leukocytosis                                                  2 (4%)       1 (2%)                                             
      Necrosis                                         1 (2%)                                 2 (4%)                                
      Vacuolization Cytoplasmic                        8 (16%)      4 (8%)       6 (12%)      5 (10%)                               
      Bile Duct, Hyperplasia                           2 (4%)       6 (12%)                   3 (6%)                                
      Centrilobular, Necrosis                                       1 (2%)                                                          
   Mesentery                                          (4)          (2)          (7)          (5)                                    
      Fat, Necrosis, Focal                             3 (75%)      1 (50%)      5 (71%)      3 (60%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Atrophy                                                                    2 (4%)                                             
      Atrophy, Focal                                  13 (26%)      8 (16%)     11 (22%)     19 (38%)                               
      Autolysis                                        1 (2%)                                 2 (4%)                                
      Ectopic Liver                                                              1 (2%)                                             
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic                            2 (4%)                                                                       
      Duct, Ectasia                                    1 (2%)                                                                       
   Salivary Glands                                    (50)                                   (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Duct, Inflammation, Chronic                      1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (2)                       (50)                                   
      Hyperplasia                                      3 (6%)       1 (50%)                   1 (2%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            3 (6%)                                 1 (2%)                                
      Mineralization                                   1 (2%)                                 2 (4%)                                
      Ulcer                                            1 (2%)       1 (50%)                                                         
   Stomach, Glandular                                 (50)         (1)                       (50)                                   
      Autolysis                                                                               1 (2%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Mineralization                                  16 (32%)                               22 (44%)                               
      Necrosis                                                      1 (100%)                                                        
   Tongue                                                          (1)                       (1)                                    
      Epithelium, Hyperplasia, Focal                                                          1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Mineralization                                   1 (100%)                                                                     
   Heart                                              (50)                                   (50)                                   
      Inflammation, Chronic                           42 (84%)                               46 (92%)                               
      Mineralization                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (1)                       (50)                                   
      Congestion                                                                              3 (6%)                                
      Cyst                                             1 (2%)                                                                       
      Ectasia                                          3 (6%)                                 5 (10%)                               
      Hyperplasia                                     13 (26%)                               18 (36%)                               
      Hypertrophy                                     10 (20%)                               10 (20%)                               
      Vacuolization Cytoplasmic                       14 (28%)                                7 (14%)                               
   Adrenal Gland, Medulla                             (49)         (1)          (1)          (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Hyperplasia                                      7 (14%)                                3 (6%)                                
   Islets, Pancreatic                                 (50)         (49)         (49)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Atypia Cellular                                                            2 (4%)       2 (4%)                                
      Autolysis                                                                               1 (2%)                                
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (50)         (1)                       (50)                                   
      Hyperplasia                                                   1 (100%)                                                        
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Angiectasis                       1 (2%)                                 1 (2%)                                
      Pars Distalis, Cyst                             17 (34%)     15 (30%)      7 (14%)     22 (44%)                               
      Pars Distalis, Ectasia                           5 (10%)      8 (16%)      3 (6%)       5 (10%)                               
      Pars Distalis, Hemorrhage                                                               1 (2%)                                
      Pars Distalis, Hyperplasia                       9 (18%)     10 (20%)     11 (22%)     11 (22%)                               
      Pars Distalis, Hypertrophy                       3 (6%)       1 (2%)                    1 (2%)                                
      Pars Intermedia, Cyst                            1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                             33 (66%)     26 (52%)     32 (64%)     24 (48%)                               
      Follicle, Cyst                                                             2 (4%)                                             
      Follicle, Dilatation                                          1 (2%)                                                          
      Follicular Cell, Hyperplasia                                  2 (4%)       1 (2%)                                             
      Follicular Cell, Hyperplasia, Cystic                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (48)         (47)         (49)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia                                      5 (11%)      3 (6%)       1 (2%)       1 (2%)                                
      Inflammation, Acute                              5 (11%)      1 (2%)       5 (11%)      3 (6%)                                
      Inflammation, Chronic                            3 (6%)       3 (6%)       2 (4%)       7 (14%)                               
      Duct, Cyst                                                                              1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Duct, Dilatation                                              1 (2%)                                                          
      Duct, Ectasia                                    1 (2%)                    1 (2%)                                             
   Ovary                                              (50)         (4)          (1)          (50)                                   
      Follicle, Cyst                                   2 (4%)       1 (25%)                   1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                          2 (4%)       1 (2%)                                             
      Dilatation                                       4 (8%)       3 (6%)       2 (4%)       4 (8%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Cervix, Cyst                                                  2 (4%)                                                          
      Cervix, Inflammation, Acute                      1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                 2 (4%)                                                                       
   Vagina                                             (8)                       (1)          (4)                                    
      Inflammation, Acute                              1 (13%)                                                                      
      Inflammation, Chronic                                                                   1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                                        (1)                                                 
      Polychromasia                                                              1 (100%)                                           
   Bone Marrow                                        (50)         (1)          (1)          (50)                                   
      Autolysis                                                                               1 (2%)                                
      Hyperplasia                                      1 (2%)                                                                       
      Hypoplasia                                       2 (4%)       1 (100%)                                                        
      Myelofibrosis                                    2 (4%)                                                                       
      Myeloid Cell, Hyperplasia                        1 (2%)                                 3 (6%)                                
   Lymph Node                                         (50)         (2)          (2)          (50)                                   
      Inguinal, Hyperplasia                                                                   1 (2%)                                
      Mediastinal, Congestion                                                                 1 (2%)                                
      Mesenteric, Congestion                           1 (2%)                                 1 (2%)                                
      Mesenteric, Pigmentation                                                                9 (18%)                               
      Pancreatic, Ectasia                                                                     1 (2%)                                
      Pancreatic, Hyperplasia                                                                 1 (2%)                                
   Lymph Node, Mandibular                             (50)                      (1)          (50)                                   
      Congestion                                       4 (8%)                                 2 (4%)                                
      Hemorrhage                                                                 1 (100%)                                           
      Hyperplasia                                      3 (6%)                                                                       
      Hyperplasia, Re Cell                                                                    1 (2%)                                
   Spleen                                             (50)         (50)         (49)         (50)                                   
      Atrophy, Focal                                                                          1 (2%)                                
      Congestion                                       1 (2%)                                                                       
      Ectasia                                          1 (2%)                                                                       
      Fibrosis                                                                                1 (2%)                                
      Hematopoietic Cell Proliferation                              1 (2%)       2 (4%)       1 (2%)                                
      Hematopoietic Cell Proliferation Granulocytic    4 (8%)       3 (6%)       1 (2%)       3 (6%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation Erythrocytic                 1 (2%)       3 (6%)                                             
      Hemorrhage, Focal                                             1 (2%)                                                          
      Infarct                                                       1 (2%)                                                          
   Thymus                                             (49)                                   (48)                                   
      Cyst                                             3 (6%)                                 1 (2%)                                
      Medulla, Hyperplasia                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (38)         (32)         (50)                                   
      Galactocele                                      1 (2%)                                                                       
      Hyperplasia                                      4 (8%)       4 (11%)      5 (16%)      4 (8%)                                
      Inflammation, Acute                                           1 (3%)                                                          
      Duct, Ectasia                                   30 (60%)     20 (53%)     22 (69%)     18 (36%)                               
      Duct, Hyperplasia                                             1 (3%)                                                          
   Skin                                               (50)         (8)          (2)          (49)                                   
      Acanthosis                                                    2 (25%)                                                         
      Hyperkeratosis                                                2 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (5)          (10)         (50)                                   
      Osteopetrosis                                    3 (6%)       5 (100%)    10 (100%)     7 (14%)                               
   Skeletal Muscle                                                              (1)          (1)                                    
      Cyst                                                                       1 (100%)                                           
      Foreign Body                                                                            1 (100%)                              
      Inflammation, Chronic                                                                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (5)          (3)          (50)                                   
      Compression                                     13 (26%)      3 (60%)      3 (100%)     7 (14%)                               
      Gliosis, Focal                                                             1 (33%)                                            
      Meninges, Infiltration Cellular, Lymphocyte                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (4)          (8)          (50)                                   
      Congestion                                       3 (6%)                    2 (25%)                                            
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                                                 2 (25%)                                            
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Inflammation, Acute                              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolus, Infiltration Cellular, Histiocyte      4 (8%)                                 6 (12%)                               
      Alveolus, Mineralization                         1 (2%)                                                                       
      Epithelium, Alveolus, Hyperplasia                1 (2%)                                 1 (2%)                                
   Nose                                               (50)                                   (50)                                   
      Foreign Body                                     1 (2%)                                 3 (6%)                                
      Fungus                                           1 (2%)                                 2 (4%)                                
      Mucosa, Inflammation, Chronic Active             4 (8%)                                 5 (10%)                               
      Nasolacrimal Duct, Cyst                          1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic         5 (10%)                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)          (1)          (2)                                    
      Lens, Cataract                                   1 (100%)     2 (100%)     1 (100%)     1 (50%)                               
      Retina, Degeneration                                                       1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (45)         (44)         (50)                                   
      Autolysis                                        1 (2%)                                 2 (4%)                                
      Congestion                                                                 3 (7%)                                             
      Hydronephrosis                                   2 (4%)                    1 (2%)                                             
      Infarct                                          1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Mineralization                                   6 (12%)                                7 (14%)                               
      Nephropathy                                     48 (96%)     44 (98%)     43 (98%)     46 (92%)                               
      Cortex, Cyst                                                                            1 (2%)                                
      Renal Tubule, Hyperplasia                        2 (4%)       2 (4%)                    2 (4%)                                
      Renal Tubule, Epithelium, Degeneration                                                  1 (2%)                                
   Ureter                                             (1)                                                                           
      Inflammation, Chronic                            1 (100%)                                                                     
   Urinary Bladder                                    (50)         (2)                       (50)                                   
      Hyperplasia                                                   1 (50%)                                                         
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (50%)                                                         
      Metaplasia, Squamous                                          1 (50%)                                                         
      Mineralization                                                1 (50%)                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10            9                                     
  Early Deaths                                                                                                                      
    Moribund                                          24           14           11           11                                     
    Dead                                               4            6            3            5                                     
    Moribund Sacrifice                                              1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           29           36           35                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (1)                       (50)                                   
      Autolysis                                        1 (2%)       1 (100%)                  4 (8%)                                
      Diverticulum                                                                            1 (2%)                                
      Edema                                            1 (2%)                                                                       
      Inflammation, Acute                              2 (4%)                                                                       
      Parasite Metazoan                                                                       1 (2%)                                
   Intestine Large, Colon                             (50)         (1)                       (50)                                   
      Autolysis                                        1 (2%)                                 3 (6%)                                
      Hyperplasia, Lymphoid                            2 (4%)                                 2 (4%)                                
      Hyperplasia, Adenomatous                                                                1 (2%)                                
      Mineralization                                   1 (2%)                                                                       
      Parasite Metazoan                                5 (10%)                                9 (18%)                               
   Intestine Large, Rectum                            (50)         (1)                       (50)                                   
      Autolysis                                        1 (2%)                                 3 (6%)                                
      Mineralization                                   1 (2%)                                                                       
      Parasite Metazoan                                7 (14%)                                8 (16%)                               
   Intestine Small, Duodenum                          (50)         (1)                       (50)                                   
      Autolysis                                        1 (2%)                                 3 (6%)                                
   Intestine Small, Ileum                             (50)         (7)          (17)         (50)                                   
      Autolysis                                        2 (4%)       1 (14%)                   3 (6%)                                
      Hyperplasia, Lymphoid                           11 (22%)      6 (86%)     15 (88%)     15 (30%)                               
      Inflammation                                                               1 (6%)                                             
      Pigmentation                                                               6 (35%)      4 (8%)                                
   Intestine Small, Jejunum                           (50)         (1)          (5)          (50)                                   
      Autolysis                                        2 (4%)       1 (100%)                  4 (8%)                                
      Hyperplasia, Lymphoid                            5 (10%)                   3 (60%)      3 (6%)                                
      Intussusception                                                            1 (20%)                                            
      Pigmentation                                                                            3 (6%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Autolysis                                                     2 (4%)                    1 (2%)                                
      Basophilic Focus, Multiple                      10 (20%)      2 (4%)      10 (20%)      7 (14%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Clear Cell Focus                                 2 (4%)       1 (2%)       2 (4%)       5 (10%)                               
      Congestion                                                                              1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Cytoplasmic Alteration, Focal                    1 (2%)                                                                       
      Ectasia                                          2 (4%)                                 1 (2%)                                
      Eosinophilic Focus                               1 (2%)                    1 (2%)       4 (8%)                                
      Eosinophilic Focus, Multiple                     1 (2%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                       6 (12%)      6 (12%)     10 (20%)      6 (12%)                               
      Hyperplasia, Focal                               3 (6%)       1 (2%)       1 (2%)       5 (10%)                               
      Hypertrophy, Focal                               1 (2%)       2 (4%)                    4 (8%)                                
      Hypertrophy, Multifocal                                                                 1 (2%)                                
      Infarct                                                       1 (2%)                                                          
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Granulomatous                      1 (2%)                    1 (2%)       4 (8%)                                
      Leukocytosis                                     1 (2%)       7 (14%)                                                         
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                       2 (4%)                                                                       
      Vacuolization Cytoplasmic                                     5 (10%)      3 (6%)       1 (2%)                                
      Bile Duct, Hyperplasia                          10 (20%)     14 (28%)     22 (44%)     17 (34%)                               
      Centrilobular, Necrosis                          2 (4%)                    1 (2%)       2 (4%)                                
      Centrilobular, Vacuolization Cytoplasmic                                                2 (4%)                                
      Hepatocyte, Degeneration, Cystic                              3 (6%)       6 (12%)      9 (18%)                               
   Mesentery                                          (11)         (5)          (7)          (11)                                   
      Autolysis                                        1 (9%)                                                                       
      Hemorrhage                                                    1 (20%)                                                         
      Inflammation, Acute                              1 (9%)                                                                       
      Inflammation, Chronic                                         2 (40%)                   1 (9%)                                
      Necrosis, Focal                                               1 (20%)      3 (43%)                                            
      Artery, Inflammation, Chronic                                                           1 (9%)                                
      Fat, Necrosis                                    5 (45%)      1 (20%)                   6 (55%)                               
   Pancreas                                           (50)                      (2)          (49)                                   
      Atrophy, Diffuse                                                                        1 (2%)                                
      Atrophy, Focal                                  23 (46%)                               21 (43%)                               
      Autolysis                                        2 (4%)                                 1 (2%)                                
      Cytoplasmic Alteration                                                                  1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Artery, Hypertrophy                                                        1 (50%)                                            
      Artery, Inflammation, Chronic                    2 (4%)                                 3 (6%)                                
      Duct, Cyst                                                                              1 (2%)                                
   Salivary Glands                                    (49)         (1)                       (50)                                   
      Atrophy                                          2 (4%)                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Vacuolization Cytoplasmic                                                               1 (2%)                                
      Acinar Cell, Cytoplasmic Alteration                                                     1 (2%)                                
   Stomach, Forestomach                               (50)         (1)                       (50)                                   
      Hyperkeratosis                                   1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia                                      1 (2%)                                 3 (6%)                                
      Inflammation, Acute                                                                     2 (4%)                                
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (1)                       (50)                                   
      Autolysis                                        1 (2%)                                                                       
      Mineralization                                   3 (6%)                                 5 (10%)                               
      Ulcer                                            1 (2%)                                                                       
      Mucosa, Cyst                                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Aorta, Mineralization                            1 (100%)                                                                     
   Heart                                              (50)         (3)          (5)          (50)                                   
      Inflammation, Chronic                           43 (86%)      1 (33%)                  50 (100%)                              
      Mineralization                                   2 (4%)                                                                       
      Atrium Left, Thrombosis                          1 (2%)       2 (67%)      5 (100%)    10 (20%)                               
      Valve, Inflammation, Acute                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (2)                       (50)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                     12 (25%)      1 (50%)                  18 (36%)                               
      Hypertrophy                                      4 (8%)                                 1 (2%)                                
      Vacuolization Cytoplasmic                        7 (15%)      1 (50%)                   8 (16%)                               
   Adrenal Gland, Medulla                             (48)         (6)          (5)          (50)                                   
      Hyperplasia                                      6 (13%)                               15 (30%)                               
      Thrombosis                                                                 1 (20%)                                            
      Bilateral, Hyperplasia                           1 (2%)                                 2 (4%)                                
   Islets, Pancreatic                                 (50)                      (2)          (49)                                   
      Autolysis                                                                               1 (2%)                                
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (49)         (1)          (1)          (49)                                   
      Hyperplasia                                      1 (2%)                    1 (100%)     2 (4%)                                
   Pituitary Gland                                    (50)         (16)         (9)          (49)                                   
      Pars Distalis, Cyst                              7 (14%)                   1 (11%)      5 (10%)                               
      Pars Distalis, Ectasia                                        1 (6%)                                                          
      Pars Distalis, Hemorrhage                        1 (2%)       1 (6%)                    1 (2%)                                
      Pars Distalis, Hyperplasia                      14 (28%)      2 (13%)                   8 (16%)                               
      Pars Distalis, Hypertrophy                       9 (18%)                                5 (10%)                               
      Pars Distalis, Pigmentation                                                1 (11%)                                            
      Pars Intermedia, Hyperplasia                     2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Nervosa, Cyst                                                                      1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Ultimobranchial Cyst                                                                    1 (2%)                                
      C-Cell, Hyperplasia                             17 (34%)     19 (38%)     19 (39%)     13 (26%)                               
      Follicle, Cyst                                                2 (4%)       2 (4%)                                             
      Follicle, Dilatation                             2 (4%)       1 (2%)       3 (6%)       4 (8%)                                
      Follicular Cell, Hyperplasia                     1 (2%)       1 (2%)                                                          
      Follicular Cell, Hyperplasia, Cystic             1 (2%)       5 (10%)                   1 (2%)                                
      Follicular Cell, Hypertrophy                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)          (1)                                                              
      Inflammation, Chronic Active                     1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (2)                       (48)                                   
      Granuloma Sperm                                  1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
   Preputial Gland                                    (49)         (9)          (8)          (49)                                   
      Cyst                                                          1 (11%)                                                         
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Acute                              9 (18%)      1 (11%)                   3 (6%)                                
      Inflammation, Chronic                           14 (29%)      1 (11%)                  14 (29%)                               
      Inflammation, Chronic Active                                  1 (11%)                                                         
   Prostate                                           (50)         (3)          (2)          (49)                                   
      Cyst                                                                                    1 (2%)                                
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Acute                              8 (16%)      1 (33%)      2 (100%)     4 (8%)                                
      Inflammation, Chronic                           20 (40%)      1 (33%)                  23 (47%)                               
   Seminal Vesicle                                    (50)         (2)                       (49)                                   
      Dilatation                                       1 (2%)       1 (50%)                   2 (4%)                                
      Inflammation, Acute                                           1 (50%)                                                         
      Epithelium, Degeneration                                                                1 (2%)                                
   Testes                                             (50)         (44)         (44)         (49)                                   
      Atrophy                                          1 (2%)                    2 (5%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Bilateral, Interstitial Cell, Hyperplasia        2 (4%)                                 1 (2%)                                
      Interstitial Cell, Hyperplasia                                1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (5)                                                                           
      Anemia                                           2 (40%)                                                                      
   Bone Marrow                                        (50)         (2)                       (50)                                   
      Autolysis                                        2 (4%)                                 1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hypoplasia                                                                              3 (6%)                                
      Myelofibrosis                                                                           1 (2%)                                
      Myeloid Cell, Hyperplasia                        1 (2%)       1 (50%)                   2 (4%)                                
   Lymph Node                                         (49)         (7)          (9)          (48)                                   
      Axillary, Hyperplasia, Re Cell                                                          1 (2%)                                
      Inguinal, Hyperplasia, Re Cell                                             1 (11%)                                            
      Mediastinal, Hemorrhage                                       1 (14%)      1 (11%)      1 (2%)                                
      Mediastinal, Hyperplasia, Re Cell                                                       1 (2%)                                
      Mesenteric, Autolysis                            1 (2%)                                                                       
      Mesenteric, Congestion                                                                  2 (4%)                                
      Mesenteric, Ectasia                                                        1 (11%)                                            
      Mesenteric, Hemorrhage                           1 (2%)                    1 (11%)                                            
      Mesenteric, Hyperplasia, Re Cell                                                        1 (2%)                                
      Mesenteric, Pigmentation                                                   4 (44%)     10 (21%)                               
      Mesenteric, Lymphocyte, Depletion Cellular       1 (2%)                                                                       
      Pancreatic, Congestion                           1 (2%)                                                                       
      Pancreatic, Ectasia                              2 (4%)                                                                       
      Pancreatic, Hyperplasia                          1 (2%)                                 1 (2%)                                
      Pancreatic, Hyperplasia, Re Cell                              1 (14%)                                                         
   Lymph Node, Mandibular                             (49)         (2)          (3)          (48)                                   
      Congestion                                                                              1 (2%)                                
      Ectasia                                          1 (2%)                    1 (33%)      1 (2%)                                
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Hyperplasia                                      1 (2%)                    1 (33%)      4 (8%)                                
      Hyperplasia, Re Cell                             1 (2%)                                                                       
   Spleen                                             (50)         (50)         (48)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Autolysis                                                     1 (2%)                    1 (2%)                                
      Congestion                                       4 (8%)       1 (2%)                    1 (2%)                                
      Fibrosis                                         4 (8%)       3 (6%)       1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation Granulocytic    1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Hematopoietic Cell Proliferation Erythrocytic                 1 (2%)                                                          
      Infarct                                                       1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Pigmentation                                                                            1 (2%)                                
   Thymus                                             (49)         (1)                       (46)                                   
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (46)         (44)         (43)                                   
      Cyst                                                          1 (2%)                                                          
      Galactocele                                      1 (2%)       1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      4 (8%)       7 (15%)      9 (20%)      6 (14%)                               
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Duct, Ectasia                                    3 (6%)      12 (26%)      7 (16%)      5 (12%)                               
   Skin                                               (50)         (14)         (13)         (50)                                   
      Acanthosis                                                    1 (7%)       1 (8%)                                             
      Congestion                                       1 (2%)                                                                       
      Cyst Epithelial Inclusion                                                  1 (8%)                                             
      Hyperkeratosis                                                             1 (8%)       1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Face, Inflammation, Chronic                                                             1 (2%)                                
      Subcutaneous Tissue, Abscess                                                            1 (2%)                                
      Subcutaneous Tissue, Cyst                                     1 (7%)                                                          
      Subcutaneous Tissue, Fibrosis                                 1 (7%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)       1 (7%)       1 (8%)                                             
      Tail, Acanthosis                                              4 (29%)                                                         
      Tail, Cyst Epithelial Inclusion                                                         2 (4%)                                
      Tail, Hyperkeratosis                                          4 (29%)      1 (8%)       1 (2%)                                
      Tail, Inflammation, Acute                                     1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (1)                       (50)                                   
      Fibrous Osteodystrophy                           1 (2%)                                 3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (3)          (4)          (50)                                   
      Compression                                      2 (4%)       1 (33%)      1 (25%)      5 (10%)                               
      Hydrocephalus                                    1 (2%)                                                                       
      Inflammation, Acute, Multifocal                  1 (2%)                                                                       
      Choroid Plexus, Infiltration Cellular,                                                                                        
          Lymphocyte                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (6)          (3)          (50)                                   
      Autolysis                                                                               1 (2%)                                
      Congestion                                       1 (2%)                    1 (33%)      1 (2%)                                
      Hemorrhage                                       1 (2%)       1 (17%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Hyperplasia, Lymphoid                                                                   5 (10%)                               
      Inflammation, Chronic                            2 (4%)                                 2 (4%)                                
      Inflammation, Granulomatous                                                             1 (2%)                                
      Mineralization                                   1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                                                       
      Alveolus, Infiltration Cellular, Histiocyte      5 (10%)                                1 (2%)                                
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                   1 (2%)                                 1 (2%)                                
   Nose                                               (50)         (1)          (1)          (49)                                   
      Autolysis                                                                               1 (2%)                                
      Foreign Body                                     5 (10%)                                5 (10%)                               
      Fungus                                           4 (8%)                                 2 (4%)                                
      Hyperkeratosis                                                             1 (100%)                                           
      Inflammation, Chronic                            4 (8%)                                 4 (8%)                                
      Inflammation, Chronic Active                                               1 (100%)                                           
      Metaplasia, Squamous                                                       1 (100%)                                           
      Mucosa, Inflammation, Chronic Active             9 (18%)                                9 (18%)                               
      Mucosa, Glands, Exudate                                                                 1 (2%)                                
      Nasolacrimal Duct, Inflammation, Acute                        1 (100%)                                                        
      Nasolacrimal Duct, Inflammation, Chronic         5 (10%)                               11 (22%)                               
      Respiratory Epithelium, Hyperplasia              3 (6%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)                       (2)                                    
      Bilateral, Lens, Cataract                                                               1 (50%)                               
      Bilateral, Retina, Degeneration                                                         1 (50%)                               
      Cornea, Inflammation, Chronic                                                           1 (50%)                               
      Lens, Cataract                                   1 (100%)     1 (100%)                                                        
      Retina, Degeneration                             1 (100%)                                                                     
      Retina, Inflammation, Chronic                                 1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (48)         (50)         (50)                                   
      Autolysis                                                     1 (2%)                    1 (2%)                                
      Congestion                                                    1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Acute, Multifocal                  1 (2%)                                                                       
      Mineralization                                                                          1 (2%)                                
      Nephropathy                                     49 (98%)     48 (100%)    49 (98%)     49 (98%)                               
      Cortex, Cyst                                                               2 (4%)       2 (4%)                                
      Renal Tubule, Degeneration                       1 (2%)                                                                       
      Renal Tubule, Hyperplasia                        3 (6%)       6 (13%)      5 (10%)      8 (16%)                               
      Renal Tubule, Hypertrophy, Focal                                           1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Epithelium, Hypertrophy, Focal     1 (2%)                                                                       
   Urinary Bladder                                    (50)         (1)                       (49)                                   
      Mineralization                                                                          1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
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                             ----------              END OF REPORT             ----------                                           
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