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TDMS Study 05021-03 Pathology Tables

NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97
Route: DOSED FEED                                                                                                 Time: 08:49:39




       Facility:  Southern Research Institute

       Chemical CAS #:  6471-49-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|             
                             DAY ON TEST   | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|             
                                           | 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 | X  X        X                       X     X                       X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +              +                 +                                 |             
      Sarcoma                              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |             X                                                  X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X  X              X  X  X  X  X                 X  X     X  X  X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |          X  X                                         X                  |             
      C-Cell, Carcinoma                    |             X                                                            |             
      Follicular Cell, Carcinoma           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|             
                             DAY ON TEST   | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|             
                                           | 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                 X                                 |             
      Carcinoma                            |                   X                                X                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Polyp Stromal           |             X                 X        X           X                    X|             
      Endometrium, Sarcoma Stromal         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +  +                    +                       +     +            |             
      Fibrosarcoma                         |                                                                          |             
      Leiomyosarcoma                       |                                                             X            |             
      Schwannoma Malignant                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |    X                                                                     |             
      Mediastinal, Leukemia Mononuclear    |    X                                                                     |             
      Mesenteric, Leukemia Mononuclear     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X        X                    X  X     X                       X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Thymoma Benign                       |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         | X        X  X                    X  X     X  X  X     X        X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                    X                     |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glioma NOS                           |                      X                                                   |             
      Oligodendroglioma NOS                |                X                                                         |             
      Meninges, Granular Cell Tumor Benign |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|             
                             DAY ON TEST   | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|             
                                           | 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 | X  X                                                              X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X        X                    X  X     X                       X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                 X                        |             
      Leukemia Mononuclear                 |       X     X     X                    X           X           X         |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                        |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                                                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X              X                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Pheochromocytoma Malignant           |                                     X                                    |             
      Pheochromocytoma Benign              |                                                                   X      |             
      Bilateral, Pheochromocytoma Benign   | X                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X        X  X     X  X     X     X     X  X  X     X     X     X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                X                                                     X   |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X  X     X                           |             
      Carcinoma                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Polyp Stromal           |                            X                 X                           |             
      Endometrium, Sarcoma Stromal         |    X                                                                     |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                             +  +  +      |             
      Fibrosarcoma                         |                                                             X            |             
      Leiomyosarcoma                       |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mesenteric, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X                    X           X           X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                X         |             
      Fibroadenoma                         |    X  X  X        X     X  X        X  X        X     X        X  X  X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                  X                                       |             
      Subcutaneous Tissue, Lipoma          |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glioma NOS                           |                                                                          |             
      Oligodendroglioma NOS                |                                                                          |             
      Meninges, Granular Cell Tumor Benign |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                X         |             
      Leukemia Mononuclear                 |       X                                X           X                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ureter                                  |    +                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X                    X           X           X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         13 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Adenoma               |                                                                          |         29 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Adenoma                      |                                                                          |          5 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  47        |
      Adenoma                              |                                                                          |          5 |
      Carcinoma                            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Endometrium, Polyp Stromal           |                                                                          |          7 |
      Endometrium, Sarcoma Stromal         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   8        |
      Fibrosarcoma                         |                                                                          |          1 |
      Leiomyosarcoma                       |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Mesenteric, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
      Carcinoma                            |                                                                          |          1 |
      Fibroadenoma                         |                                                                          |         23 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Keratoacanthoma                      |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Glioma NOS                           |                                                                          |          1 |
      Oligodendroglioma NOS                |                                                                          |          1 |
      Meninges, Granular Cell Tumor Benign |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |         14 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +           +           +               |             
      Carcinoma                            |                                              X                           |             
      Sarcoma                              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                       X  X               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |          X                                X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                   X      |             
      Carcinoma                            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                X  X  X     X                 X  X  X     X  X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                  X                                       |             
      C-Cell, Carcinoma                    |                                                          X               |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Carcinoma           |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                          X      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Polyp Stromal           |          X           X           X     X        X        X           X   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +              +                                   +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |    X                                                                     |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |    X           X  X  X     X        X        X  X  X  X                 X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      | X                                                                        |             
      Subcutaneous Tissue, Fibrosarcoma    |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma NOS                      |                               X                          X               |             
      Leukemia Mononuclear                 |                                                                          |             
      Meningioma Malignant                 |                                                          X               |             
      Choroid Plexus, Meningioma Malignant,|                                                                          |             
           Metastatic, Brain               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |          X                                   X                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                 +                                 |             
      Carcinoma                            |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Pheochromocytoma Benign              |                                        X  X                       X  X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X                    X                                       |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |             X  X     X  X  X  X                             X  X     X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |             X                                                            |             
      C-Cell, Carcinoma                    |                X                                      X                  |             
      Follicular Cell, Adenoma             |                                                          X  X           X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Polyp Stromal           | X  X  X                                X                 X     X         |             
                                            __________________________________________________________________________|             
   Vagina                                  |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                         X                                                |             
      Fibroadenoma                         | X  X  X                                      X           X  X  X        X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma NOS                      |                                                    X                     |             
      Leukemia Mononuclear                 |                                              X                           |             
      Meningioma Malignant                 |                                                                          |             
      Choroid Plexus, Meningioma Malignant,|                                                                          |             
           Metastatic, Brain               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal Tubule, Adenoma                |                            X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                   X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Carcinoma                            |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Adenoma                              |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
      Adenoma                              |                                                                          |          3 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               |                                                                          |         18 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Adenoma                      |                                                                          |          2 |
      C-Cell, Carcinoma                    |                                                                          |          3 |
      Follicular Cell, Adenoma             |                                                                          |          3 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  49        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Endometrium, Polyp Stromal           |                                                                          |         13 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Hemangioma                           |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                                                                          |         19 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  49        |
      Keratoacanthoma                      |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Astrocytoma NOS                      |                                                                          |          3 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Meningioma Malignant                 |                                                                          |          1 |
      Choroid Plexus, Meningioma Malignant,|                                                                          |            |
           Metastatic, Brain               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 5| 7| 7| 5| 5| 6| 6| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 7| 3| 3| 6| 9| 6| 8| 3| 5| 0| 3| 3| 3| 9| 5| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 2| 5| 2| 2| 2| 4| 5| 2| 8| 2| 7| 1| 2| 2| 2| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +                                          |             
      Fibrosarcoma, Metastatic, Uterus     |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +              +     +     +        +  +  +        +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +              +     +     +        +     +        +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +                                         +                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Fibrosarcoma, Metastatic, Uterus     |                               X                                          |             
      Leukemia Mononuclear                 |       X              X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +              +                       +                 +|             
      Carcinoma, Metastatic, Ovary         |                X                                                         |             
      Fibrosarcoma, Metastatic, Uterus     |                               X                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                   +                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                   +                                                      |             
      Pheochromocytoma Malignant           |                   X                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X     X  X  X     X  X  X        X  X  X        X  X        X  X  X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                       X                  |             
      C-Cell, Adenoma                      |                                                 X           X            |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
      Mediastinum, Myxoma                  |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
      Carcinoma                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +                                                         |             
      Carcinoma                            |                X                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Ovary         |                X                                                         |             
      Fibrosarcoma                         |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 5| 7| 7| 5| 5| 6| 6| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 7| 3| 3| 6| 9| 6| 8| 3| 5| 0| 3| 3| 3| 9| 5| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 2| 5| 2| 2| 2| 4| 5| 2| 8| 2| 7| 1| 2| 2| 2| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leiomyoma                            |                                                                          |             
      Cervix, Endometrium, Polyp Stromal   |                                                                          |             
      Endometrium, Polyp Stromal           |                                                    X                     |             
      Endometrium, Sarcoma Stromal         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                +                                                         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +                                                                  |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                                                         |             
      Lumbar, Carcinoma, Metastatic, Ovary |                X                                                         |             
      Renal, Carcinoma, Metastatic, Ovary  |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Fibrosarcoma, Metastatic, Uterus     |                               X                                          |             
      Leukemia Mononuclear                 |       X              X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +  +     +     +        +  +  +  +  +  +        +  +  +  +     +|             
      Adenoma                              |                                                          X               |             
      Fibroadenoma                         | X                       X           X        X              X  X         |             
                                            __________________________________________________________________________|             
   Skin                                    |    +                                                                     |             
      Sebaceous Gland, Carcinoma           |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                         +           +           +        +              +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                         +                                   +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +           +  +           +                          +               |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Ovary         |                X                                                         |             
      Carcinoma, Metastatic, Skin          |    X                                                                     |             
      Fibrosarcoma, Metastatic, Uterus     |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Squamous Cell Papilloma       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 5| 7| 7| 5| 5| 6| 6| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 7| 3| 3| 6| 9| 6| 8| 3| 5| 0| 3| 3| 3| 9| 5| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 2| 5| 2| 2| 2| 4| 5| 2| 8| 2| 7| 1| 2| 2| 2| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 4| 1| 3| 3| 3|             
                                           | 1| 5| 5| 5| 5| 5| 2| 2| 5| 5| 5| 5| 5| 5| 5| 8| 3| 5| 5| 5| 6| 2| 2| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
      Fibrosarcoma, Metastatic, Uterus     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +        +     +     +  +  +     +           +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +        +     +     +  +  +     +           +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                         +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                    X                     |             
      Fibrosarcoma, Metastatic, Uterus     |                                                                          |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +        +                             +   |             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Fibrosarcoma, Metastatic, Uterus     |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X  X  X  X  X              X     X  X              X     X  X  X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |          X                                      X                        |             
      C-Cell, Carcinoma                    |          X                    X  X        X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mediastinum, Myxoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +|             
      Adenoma                              |    X                          X                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 4| 1| 3| 3| 3|             
                                           | 1| 5| 5| 5| 5| 5| 2| 2| 5| 5| 5| 5| 5| 5| 5| 8| 3| 5| 5| 5| 6| 2| 2| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leiomyoma                            |                                     X                                    |             
      Cervix, Endometrium, Polyp Stromal   |                                                 X                        |             
      Endometrium, Polyp Stromal           |                                  X        X        X        X     X     X|             
      Endometrium, Sarcoma Stromal         |                                                    X                     |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                   +      |             
      Sarcoma                              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +                                                   |             
      Lumbar, Carcinoma, Metastatic, Ovary |                                                                          |             
      Renal, Carcinoma, Metastatic, Ovary  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Uterus     |                                                                          |             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +     +  +     +  +     +  +  +  +  +  +  +        +        +   |             
      Adenoma                              |          X                                                               |             
      Fibroadenoma                         |          X                       X  X  X     X  X           X        X   |             
                                            __________________________________________________________________________|             
   Skin                                    |                            +                                             |             
      Sebaceous Gland, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                   +              +  +              +  +                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +        +                                                      |             
      Alveolar/Bronchiolar Adenoma         |          X                                                               |             
      Carcinoma, Metastatic, Ovary         |                                                                          |             
      Carcinoma, Metastatic, Skin          |                                                                          |             
      Fibrosarcoma, Metastatic, Uterus     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +                                             |             
      Pinna, Squamous Cell Papilloma       |                            X                                             |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 4| 1| 3| 3| 3|             
                                           | 1| 5| 5| 5| 5| 5| 2| 2| 5| 5| 5| 5| 5| 5| 5| 8| 3| 5| 5| 5| 6| 2| 2| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                      +   |             
      Adenoma                              |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 9| 9| 9| 8| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |   1        |
      Fibrosarcoma, Metastatic, Uterus     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Adenoma                              |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Uterus     |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Carcinoma, Metastatic, Ovary         |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Uterus     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |   1        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Adenoma               |                                                                          |         28 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          4 |
      C-Cell, Carcinoma                    |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Mediastinum, Myxoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  47        |
      Adenoma                              |                                                                          |          3 |
      Carcinoma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 9| 9| 9| 8| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Carcinoma, Metastatic, Ovary         |                                                                          |          1 |
      Fibrosarcoma                         |                                                                          |          1 |
      Leiomyoma                            |                                                                          |          1 |
      Cervix, Endometrium, Polyp Stromal   |                                                                          |          1 |
      Endometrium, Polyp Stromal           |                                                                          |          7 |
      Endometrium, Sarcoma Stromal         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Lumbar, Carcinoma, Metastatic, Ovary |                                                                          |          1 |
      Renal, Carcinoma, Metastatic, Ovary  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Fibrosarcoma, Metastatic, Uterus     |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  32        |
      Adenoma                              |                                                                          |          2 |
      Fibroadenoma                         |                                                                          |         14 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   2        |
      Sebaceous Gland, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 9| 9| 9| 8| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |     A      |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |   8        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma, Metastatic, Ovary         |                                                                          |          1 |
      Carcinoma, Metastatic, Skin          |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Uterus     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Pinna, Squamous Cell Papilloma       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  44        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 3| 3| 3| 0| 2| 3| 3| 3| 9| 5| 2| 3| 3| 4| 1| 7| 3| 3| 0| 2| 2| 3| 3|             
                                           | 3| 9| 5| 5| 5| 7| 9| 5| 5| 5| 2| 1| 9| 5| 5| 2| 2| 3| 6| 6| 3| 7| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +        +     +  +              +  +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +        +     +  +              +  +        +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                         +                 +                       +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                          X              X  X  X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                            X         |             
      Acinar Cell, Adenoma                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +                                                         |             
                                            __________________________________________________________________________|             
   Tongue                                  |          +                                                               |             
      Squamous Cell Papilloma              |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +                                                  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +                                                                  |             
      Carcinoma                            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                          +               |             
      Pheochromocytoma Malignant           |                                                          X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                            X     X  X  X        X     X  X           X  X|             
      Pars Distalis, Carcinoma             |                   X           X                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Bilateral, C-Cell, Adenoma           | X                                                                        |             
      C-Cell, Adenoma                      |                                                                          |             
      Follicular Cell, Adenoma             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
      Adenoma                              |                                           X        X                    X|             
                                            __________________________________________________________________________|             
   Ovary                                   |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 3| 3| 3| 0| 2| 3| 3| 3| 9| 5| 2| 3| 3| 4| 1| 7| 3| 3| 0| 2| 2| 3| 3|             
                                           | 3| 9| 5| 5| 5| 7| 9| 5| 5| 5| 2| 1| 9| 5| 5| 2| 2| 3| 6| 6| 3| 7| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Granulosa Cell Tumor NOS             |                                                                          |             
      Thecoma NOS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Sarcoma Stromal              |                                                             X            |             
      Endometrium, Polyp Stromal           |                         X     X                          X               |             
      Endometrium, Sarcoma Stromal         |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                   +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                            +         |             
      Mesenteric, Leukemia Mononuclear     |                                                                X         |             
      Pancreatic, Leukemia Mononuclear     |                                                                X         |             
      Renal, Leukemia Mononuclear          |                   X                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                          X              X  X  X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +           +        +     +  +     +  +  +  +  +     +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                       X                  |             
      Fibroadenoma                         |    X  X  X  X           X        X     X  X        X     X  X        X  X|             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +     +           +        +                    +               |             
      Basal Cell Carcinoma                 |                X                                                         |             
      Subcutaneous Tissue, Fibroma         |                                     X                                    |             
      Tail, Hemangiosarcoma                |       X                                                                  |             
      Tail, Squamous Cell Papilloma        |          X                 X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                  +                             +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +                                +                        |             
      Astrocytoma NOS                      |                                                                          |             
      Glioma NOS                           |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                         +              +     +                 +         |             
      Alveolar/Bronchiolar Adenoma         |                                        X                                 |             
      Alveolar/Bronchiolar Carcinoma       |                         X                                                |             
      Leukemia Mononuclear                 |                                              X                 X         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +     +                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +     +                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 3| 3| 3| 0| 2| 3| 3| 3| 9| 5| 2| 3| 3| 4| 1| 7| 3| 3| 0| 2| 2| 3| 3|             
                                           | 3| 9| 5| 5| 5| 7| 9| 5| 5| 5| 2| 1| 9| 5| 5| 2| 2| 3| 6| 6| 3| 7| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                           X     X                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                     +                                    |             
      Papilloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X                          X              X  X  X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 7| 8| 3| 3| 3| 1| 7| 3| 3| 3|             
                                           | 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 6| 3| 6| 6| 6| 6| 4| 3| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +     +  +           +     +  +           +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +     +  +           +        +           +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                        +                          +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinar Cell, Adenoma                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                 +                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                 +                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                           X                       X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                 +                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X     X  X        X        X     X     X  X     X  X  X     X     X   |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |    X  X        X                                                        X|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +                          +                             +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 7| 8| 3| 3| 3| 1| 7| 3| 3| 3|             
                                           | 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 6| 3| 6| 6| 6| 6| 4| 3| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Granulosa Cell Tumor NOS             |                               X                                          |             
      Thecoma NOS                          |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Sarcoma Stromal              |                                                                          |             
      Endometrium, Polyp Stromal           |                                                 X                        |             
      Endometrium, Sarcoma Stromal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Mesenteric, Leukemia Mononuclear     |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +   |             
      Adenoma                              |                                                          X        X      |             
      Carcinoma                            |                                                             X            |             
      Fibroadenoma                         |       X           X  X  X        X  X  X           X  X  X           X   |             
                                            __________________________________________________________________________|             
   Skin                                    |       +                                      +                           |             
      Basal Cell Carcinoma                 |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Tail, Hemangiosarcoma                |                                                                          |             
      Tail, Squamous Cell Papilloma        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +                 +                    +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                                            +                 +         |             
      Astrocytoma NOS                      |                                                                X         |             
      Glioma NOS                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 7| 8| 3| 3| 3| 1| 7| 3| 3| 3|             
                                           | 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 6| 3| 6| 6| 6| 6| 4| 3| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +                                          |             
      Papilloma                            |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Acinar Cell, Adenoma                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |   1        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Adenoma               |                                                                          |         23 |
      Pars Distalis, Carcinoma             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          4 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  48        |
      Adenoma                              |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |   4        |
      Granulosa Cell Tumor NOS             |                                                                          |          1 |
      Thecoma NOS                          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Cervix, Sarcoma Stromal              |                                                                          |          1 |
      Endometrium, Polyp Stromal           |                                                                          |          4 |
      Endometrium, Sarcoma Stromal         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Mesenteric, Leukemia Mononuclear     |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          7 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  38        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          2 |
      Fibroadenoma                         |                                                                          |         24 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   8        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Tail, Hemangiosarcoma                |                                                                          |          1 |
      Tail, Squamous Cell Papilloma        |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |   5        |
      Astrocytoma NOS                      |                                                                          |          1 |
      Glioma NOS                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 8| 8| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |     A      |
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |   4        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Adenoma                              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  45        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |   2        |
      Papilloma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          7 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|             
                                           | 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X           X                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                      X                                                   |             
      Leiomyoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Hepatocellular Carcinoma             | X                                                                        |             
      Hepatocellular Adenoma               |                                              X                           |             
      Leukemia Mononuclear                 | X  X        X  X  X  X  X  X  X  X  X        X  X           X  X     X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                          +                              |             
      Fibrous Histiocytoma                 |                                                                          |             
      Mesothelioma Malignant               |                                           X                              |             
      Mesothelioma NOS                     |                X                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Leukemia Mononuclear                 |                                     X           X                        |             
      Mesothelioma Malignant               |                                                                          |             
      Mesothelioma NOS                     |                                                                          |             
      Acinar Cell, Adenoma                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                        +                                 |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X                                                |             
      Mesothelioma Malignant, Metastatic   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|             
                                           | 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                 X                        |             
      Leukemia Mononuclear                 |                         X                                                |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Pheochromocytoma Malignant           |                            X                                             |             
      Pheochromocytoma Benign              | X     X        X           X     X        X  X  X           X     X      |             
      Bilateral, Pheochromocytoma Benign   |             X                          X                       X        X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X                           |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pars Distalis, Adenoma               |                                                             X  X  X  X  X|             
      Pars Intermedia, Adenoma             |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                      X                                                   |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |    X                                                                     |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +     +              +  +                                             |             
      Fibroma                              |          X                 X                                             |             
      Liposarcoma                          |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                                                        |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X     X  X  X  X  X  X  X     X  X  X  X     X  X  X  X|             
      Interstitial Cell, Adenoma           |                      X                       X                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|             
                                           | 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                             +                                          |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X  X        X        X  X           X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Mesothelioma Malignant    |                                                                          |             
      Iliac, Fibrous Histiocytoma          |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                 X                        |             
      Inguinal, Leukemia Mononuclear       |                                                 X                        |             
      Mediastinal, Leukemia Mononuclear    |                                                 X                        |             
      Mesenteric, Fibrous Histiocytoma     |                                                                          |             
      Mesenteric, Leukemia Mononuclear     |                X                 X  X        X  X              X         |             
      Pancreatic, Carcinoma, Metastatic,   |                                                                          |             
           Islets, Pancreatic              |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |    X                                X        X  X              X         |             
      Renal, Fibrous Histiocytoma          |                                                                          |             
      Renal, Leukemia Mononuclear          |                X                             X  X                        |             
      Renal, Mesothelioma NOS              |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X           X        X  X              X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Leukemia Mononuclear                 | X  X        X  X  X  X  X  X  X  X  X        X  X           X  X     X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Leukemia Mononuclear                 |                X                    X           X           X  X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Keratoacanthoma                      |             X                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                           X                              |             
      Squamous Cell Papilloma              |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X        X           X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|             
                                           | 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Meninges, Granular Cell Tumor Benign |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
      Leukemia Mononuclear                 |             X  X  X     X  X  X  X  X        X  X           X  X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
      Carcinoma                            |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X           X              X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X        X  X  X  X  X  X  X  X  X        X  X           X  X     X   |             
      Mesothelioma Malignant               |                                           X                              |             
      Mesothelioma NOS                     |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|             
                                           | 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Leiomyoma                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                              X                           |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                            X                                             |             
      Leukemia Mononuclear                 |    X     X  X              X  X  X  X                    X  X  X  X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +  +                 +  +  +              +     +  +   |             
      Fibrous Histiocytoma                 |                                              X                           |             
      Mesothelioma Malignant               |                      X                                                   |             
      Mesothelioma NOS                     |                X                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                              X                           |             
      Leukemia Mononuclear                 |    X                                                                     |             
      Mesothelioma Malignant               |                      X                                                   |             
      Mesothelioma NOS                     |                X                                                         |             
      Acinar Cell, Adenoma                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                              X                           |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Mesothelioma Malignant, Metastatic   |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|             
                                           | 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                      X                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |          X                 X  X                 X  X     X           X  X|             
      Bilateral, Pheochromocytoma Benign   |       X     X        X              X                 X     X  X  X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                         X                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                       X                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Pars Distalis, Adenoma               | X                       X        X     X           X        X     X      |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                    X              X      |             
      C-Cell, Carcinoma                    |                                                                      X   |             
      Follicular Cell, Adenoma             |                                                       X                  |             
      Follicular Cell, Carcinoma           |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Fibroma                              |                                                                          |             
      Liposarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                          X                                       |             
      Carcinoma                            |             X                                               X            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                              X                           |             
      Mesothelioma NOS                     |                X                                                         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|       X  X  X  X  X  X  X  X        X  X  X     X  X  X  X  X  X  X  X  X|             
      Interstitial Cell, Adenoma           |    X                          X  X           X                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|             
                                           | 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                +              +     +                                    |             
      Leukemia Mononuclear                 |                               X     X                                    |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                             X  X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Bronchial, Mesothelioma Malignant    |                      X                                                   |             
      Iliac, Fibrous Histiocytoma          |                                              X                           |             
      Iliac, Leukemia Mononuclear          |    X                                                                     |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |    X                                                           X         |             
      Mesenteric, Fibrous Histiocytoma     |                                              X                           |             
      Mesenteric, Leukemia Mononuclear     |    X                             X                             X         |             
      Pancreatic, Carcinoma, Metastatic,   |                                                                          |             
           Islets, Pancreatic              |                         X                                                |             
      Pancreatic, Leukemia Mononuclear     |    X                             X                             X         |             
      Renal, Fibrous Histiocytoma          |                                              X                           |             
      Renal, Leukemia Mononuclear          |                                                                          |             
      Renal, Mesothelioma NOS              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |    X                             X                             X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                              X                           |             
      Leukemia Mononuclear                 |    X     X  X              X  X  X  X                    X  X  X  X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                              X                           |             
      Leukemia Mononuclear                 |    X                                                           X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                            X                    X                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                X                                                         |             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |    X                                                                     |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|             
                                           | 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Meninges, Granular Cell Tumor Benign |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |    X        X                 X  X                             X  X      |             
      Mesothelioma Malignant               |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Mesothelioma Malignant               |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X              X  X  X  X                    X  X  X  X     X|             
      Mesothelioma Malignant               |                      X                                                   |             
      Mesothelioma NOS                     |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Leiomyoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |         28 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  11        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          2 |
      Mesothelioma NOS                     |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Mesothelioma NOS                     |                                                                          |          1 |
      Acinar Cell, Adenoma                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Mesothelioma Malignant, Metastatic   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  48        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |         18 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |         12 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  49        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               |                                                                          |         12 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Adenoma                      |                                                                          |          3 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          2 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   4        |
      Fibroma                              |                                                                          |          2 |
      Liposarcoma                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  49        |
      Adenoma                              |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  50        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
      Bilateral, Interstitial Cell, Adenoma|                                                                          |         42 |
      Interstitial Cell, Adenoma           |                                                                          |          6 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   5        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
      Bronchial, Mesothelioma Malignant    |                                                                          |          1 |
      Iliac, Fibrous Histiocytoma          |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          2 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          3 |
      Mesenteric, Fibrous Histiocytoma     |                                                                          |          1 |
      Mesenteric, Leukemia Mononuclear     |                                                                          |          9 |
      Pancreatic, Carcinoma, Metastatic,   |                                                                          |            |
           Islets, Pancreatic              |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          8 |
      Renal, Fibrous Histiocytoma          |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          3 |
      Renal, Mesothelioma NOS              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  49        |
      Leukemia Mononuclear                 |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         28 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  49        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          7 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  49        |
      Fibroadenoma                         |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Meninges, Granular Cell Tumor Benign |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         18 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |         28 |
      Mesothelioma Malignant               |                                                                          |          2 |
      Mesothelioma NOS                     |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mixed Tumor Malignant, Metastatic,   |                                                                          |             
           Salivary Glands                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Hepatocellular Carcinoma             |                                                                      X   |             
      Hepatocellular Adenoma               |                                                                X         |             
      Leukemia Mononuclear                 |                               X              X  X  X                     |             
      Mesothelioma NOS                     |                                  X                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +                       +                                   +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Mesothelioma NOS                     |    X                             X                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Carcinoma, Metastatic, Stomach       |                                                                          |             
      Mesothelioma NOS                     |    X                             X                                       |             
      Acinar Cell, Adenoma                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mixed Tumor Malignant                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Stomach       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
      Mixed Tumor Malignant, Metastatic,   |                                                                          |             
           Salivary Glands                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Complex             |                      X                                                   |             
      Pheochromocytoma Benign              | X  X     X  X  X     X  X        X                                       |             
      Bilateral, Pheochromocytoma Benign   |                                           X  X        X     X  X     X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              | X                                                        X               |             
      Carcinoma                            |                         X                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
      Mixed Tumor Malignant, Metastatic,   |                                                                          |             
           Salivary Glands                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                   X                                      X           X  X|             
      Pars Nervosa, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mixed Tumor Malignant, Metastatic,   |                                                                          |             
           Salivary Glands                 |                                                                          |             
      C-Cell, Adenoma                      |                                     X     X  X                           |             
      C-Cell, Carcinoma                    |                                                                         X|             
      Follicular Cell, Adenoma             |                      X                                                   |             
      Follicular Cell, Carcinoma           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Mesothelioma NOS                     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              |    X              X                                                      |             
      Carcinoma                            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Carcinoma, Metastatic, Stomach       |                                                                          |             
      Mesothelioma NOS                     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Carcinoma, Metastatic, Stomach       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Mesothelioma NOS                     |    X                             X                                       |             
      Bilateral, Interstitial Cell, Adenoma|    X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X        X  X  X  X|             
      Interstitial Cell, Adenoma           | X                                                        X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Bronchial, Carcinoma, Metastatic,    |                                                                          |             
           Stomach                         |                                                                          |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Histiocytic                      | X                                                                        |             
      Mesenteric, Carcinoma, Metastatic,   |                                                                          |             
           Stomach                         |                                                                          |             
      Mesenteric, Leukemia Mononuclear     |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                                          |             
      Leukemia Mononuclear                 |                               X              X  X  X                     |             
      Mesothelioma NOS                     |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  I  +  +  I  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Stomach       |                                                                          |             
      Leukemia Mononuclear                 |                               X                                          |             
      Thymoma Benign                       |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  I  +  I  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Fibroadenoma                         |                                                    X                     |             
      Fibroma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                   X                                                  X   |             
      Keratoacanthoma                      |                      X                                         X         |             
      Squamous Cell Papilloma              |                                                                          |             
      Face, Keratoacanthoma                |          X                                                               |             
      Face, Neurofibroma                   |                                                       X                  |             
      Sebaceous Gland, Adenoma             |                   X                                                      |             
      Subcutaneous Tissue, Fibroma         |                                                 X                        |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                                       |             
      Abdominal, Mesothelioma NOS          |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Astrocytoma NOS                      | X                                                                        |             
      Leukemia Mononuclear                 |                               X                                          |             
      Meninges, Mixed Tumor Malignant,     |                                                                          |             
           Metastatic, Salivary Glands     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                         X                                                |             
      Fibrous Histiocytoma                 |                                                                          |             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Neurofibroma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
      Mesothelioma Malignant               |    X                             X                                       |             
      Renal Tubule, Adenoma                |                                     X                                    |             
      Renal Tubule, Carcinoma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X              X  X  X                     |             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
      Mesothelioma Malignant               |    X                             X                                       |             
      Mesothelioma NOS                     |    X                             X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|             
                                           | 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mixed Tumor Malignant, Metastatic,   |                                                                          |             
           Salivary Glands                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                    X                     |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                                         X|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +              +  +                                         +      |             
      Mesothelioma Malignant               |                                                                   X      |             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Stomach       |                                                             X            |             
      Mesothelioma NOS                     |                                                                          |             
      Acinar Cell, Adenoma                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mixed Tumor Malignant                |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Stomach       |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mixed Tumor Malignant, Metastatic,   |                                                                          |             
           Salivary Glands                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|             
                                           | 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |       X  X                    X  X                          X        X  X|             
      Bilateral, Pheochromocytoma Benign   |             X        X                 X        X                 X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                 X                        |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X                                                         |             
      Mixed Tumor Malignant, Metastatic,   |                                                                          |             
           Salivary Glands                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |          X           X        X                                      X   |             
      Pars Nervosa, Adenoma                |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mixed Tumor Malignant, Metastatic,   |                                                                          |             
           Salivary Glands                 |                                              X                           |             
      C-Cell, Adenoma                      |          X                 X                    X                    X   |             
      C-Cell, Carcinoma                    |                                                 X              X         |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                           X           X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                   X      |             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X     X  X     X                    X                                    |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Stomach       |                                                             X            |             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Stomach       |                                                             X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma NOS                     |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X     X|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|             
                                           | 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bronchial, Carcinoma, Metastatic,    |                                                                          |             
           Stomach                         |                                                             X            |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mesenteric, Carcinoma, Metastatic,   |                                                                          |             
           Stomach                         |                                                             X            |             
      Mesenteric, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma                 |                                                    X                     |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Stomach       |                                                             X            |             
      Leukemia Mononuclear                 |                                                                          |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Fibroadenoma                         |    X                                      X                              |             
      Fibroma                              |                                  X                                X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |    X                                                                     |             
      Face, Keratoacanthoma                |                                                                          |             
      Face, Neurofibroma                   |                                                                          |             
      Sebaceous Gland, Adenoma             |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                   X                                                      |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                    X                     |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Abdominal, Mesothelioma NOS          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|             
                                           | 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Astrocytoma NOS                      |             X                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
      Meninges, Mixed Tumor Malignant,     |                                                                          |             
           Metastatic, Salivary Glands     |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Fibrous Histiocytoma                 |                                                    X                     |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +                                             |             
      Pinna, Neurofibroma                  |                            X                                             |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Renal Tubule, Adenoma                |                                                                      X   |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Mesothelioma Malignant               |                                                                   X      |             
      Mesothelioma NOS                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 6| 7| 6| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
      Mixed Tumor Malignant, Metastatic,   |                                                                          |            |
           Salivary Glands                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  11        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Mesothelioma NOS                     |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  49        |
      Carcinoma, Metastatic, Stomach       |                                                                          |          1 |
      Mesothelioma NOS                     |                                                                          |          2 |
      Acinar Cell, Adenoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Mixed Tumor Malignant                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Carcinoma, Metastatic, Stomach       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mixed Tumor Malignant, Metastatic,   |                                                                          |            |
           Salivary Glands                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 6| 7| 6| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Complex             |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |         15 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |         11 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
      Adenoma                              |                                                                          |          3 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  49        |
      Adenoma                              |                                                                          |          2 |
      Mixed Tumor Malignant, Metastatic,   |                                                                          |            |
           Salivary Glands                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  49        |
      Pars Distalis, Adenoma               |                                                                          |          8 |
      Pars Nervosa, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Mixed Tumor Malignant, Metastatic,   |                                                                          |            |
           Salivary Glands                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          7 |
      C-Cell, Carcinoma                    |                                                                          |          3 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  48        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  49        |
      Adenoma                              |                                                                          |          7 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  49        |
      Carcinoma, Metastatic, Stomach       |                                                                          |          1 |
      Mesothelioma NOS                     |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 6| 7| 6| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  49        |
      Carcinoma, Metastatic, Stomach       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  49        |
      Mesothelioma NOS                     |                                                                          |          2 |
      Bilateral, Interstitial Cell, Adenoma|                                                                          |         44 |
      Interstitial Cell, Adenoma           |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Bronchial, Carcinoma, Metastatic,    |                                                                          |            |
           Stomach                         |                                                                          |          1 |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mesenteric, Carcinoma, Metastatic,   |                                                                          |            |
           Stomach                         |                                                                          |          1 |
      Mesenteric, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  46        |
      Carcinoma, Metastatic, Stomach       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  43        |
      Fibroadenoma                         |                                                                          |          3 |
      Fibroma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Basal Cell Carcinoma                 |                                                                          |          2 |
      Keratoacanthoma                      |                                                                          |          2 |
      Squamous Cell Papilloma              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 6| 7| 6| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Face, Keratoacanthoma                |                                                                          |          1 |
      Face, Neurofibroma                   |                                                                          |          1 |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Abdominal, Mesothelioma NOS          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Astrocytoma NOS                      |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Meninges, Mixed Tumor Malignant,     |                                                                          |            |
           Metastatic, Salivary Glands     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Pinna, Neurofibroma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 6| 7| 6| 7| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Adenoma                |                                                                          |          2 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          3 |
      Mesothelioma NOS                     |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  63                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 9| 3| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 3| 3|             
                                           | 9| 8| 1| 2| 2| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 0| 2| 2| 1| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     +  +  +           +  +                       +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +     +  +  +              +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +                                   +      |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                    X                     |             
      Leukemia Mononuclear                 |                         X     X                       X     X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +                             +        +              +  +   |             
      Mesothelioma Malignant               |                                           X        X                     |             
      Osteosarcoma, Metastatic             |             X                                                            |             
      Sarcoma                              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                      +   |             
      Acinar Cell, Adenoma                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                         +                                            +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                   +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                   +     +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Complex             |                                                                   X      |             
      Pheochromocytoma Benign              |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |                                                                         X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                                                                        |             
      Carcinoma                            | X                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +     +                          +                           |             
      Pars Distalis, Adenoma               |             X     X                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                    X                    X|             
      C-Cell, Carcinoma                    |                                                                   X      |             
      Follicular Cell, Carcinoma           |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +  +           +                    +                           |             
      Adenoma                              |    X     X  X           X                    X                           |             
                                            __________________________________________________________________________|             
   Prostate                                |                                                             +            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                    X     X               |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X     X     X  X  X  X     X  X     X  X  X  X  X  X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 9| 3| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 3| 3|             
                                           | 9| 8| 1| 2| 2| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 0| 2| 2| 1| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Adenoma           |                         X                                               X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                              +              +            |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mesenteric, Leukemia Mononuclear     |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Leukemia Mononuclear                 |                         X     X                       X     X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  I  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                      X                                                   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +              +                 +        +              +|             
      Basal Cell Adenoma                   |                                                                          |             
      Fibroma                              |                                                                          |             
      Keratoacanthoma                      |                               X                                          |             
      Squamous Cell Carcinoma              |                X                                                         |             
      Subcutaneous Tissue, Fibroma         |             X                                   X                       X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                 +                                +                     |             
      Oligodendroglioma NOS                | X                                                                        |             
      Meninges, Granular Cell Tumor        |                                                                          |             
          Malignant                        |                                                    X                     |             
      Meninges, Granular Cell Tumor Benign |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +              +                                                  +      |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                   X      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                X                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 9| 3| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 3| 3|             
                                           | 9| 8| 1| 2| 2| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 0| 2| 2| 1| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Renal Tubule, Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X     X                       X     X            |             
      Mesothelioma Malignant               |                                           X        X     X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 6| 2| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 7| 6| 7| 2| 2| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 3| 5| 5| 5| 5| 3| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +           +     +  +  +  +  +  +  +                    +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +     +  +  +  +     +                       +           +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +     +                       +            |             
      Carcinoma                            |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 | X     X  X                                         X           X        X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Mesothelioma Malignant               |                                                                          |             
      Osteosarcoma, Metastatic             |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +                                                                     |             
      Acinar Cell, Adenoma                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +                       +           +                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +                                            +                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +                                            +                     |             
      Pheochromocytoma Malignant           |       X                                                                  |             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |                                                    X                     |             
      Bilateral, Pheochromocytoma Benign   | X                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +                                                                     |             
      Carcinoma                            |    X                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                             +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +     +                 +                       +  +     +      |             
      Pars Distalis, Adenoma               |          X     X                 X                       X  X     X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                   X              X                          X            |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +                    +  +                           |             
      Adenoma                              |                      X                    X  X                           |             
                                            __________________________________________________________________________|             
   Prostate                                |                                                             +            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X        X  X  X  X  X  X  X  X  X  X     X  X  X     X  X  X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 6| 2| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 7| 6| 7| 2| 2| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 3| 5| 5| 5| 5| 3| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Adenoma           |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +                       +        +  +              +            |             
      Axillary, Leukemia Mononuclear       |       X                                                                  |             
      Mediastinal, Leukemia Mononuclear    |       X  X                                                               |             
      Mesenteric, Leukemia Mononuclear     |       X  X                                                               |             
      Pancreatic, Leukemia Mononuclear     |       X                                                                  |             
      Renal, Leukemia Mononuclear          |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +                          +                                       |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |             X                                                            |             
      Leukemia Mononuclear                 | X     X  X                                         X           X        X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  I  +  +  +  +  +  +  +  I  +  I  +  +  +  +  +  +  I  +  +  +|             
      Fibroadenoma                         |                      X                                                   |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    |                   +  +              +           +     +  +              +|             
      Basal Cell Adenoma                   |                                                                         X|             
      Fibroma                              |                                                       X                  |             
      Keratoacanthoma                      |                      X                                   X               |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                      +   |             
      Oligodendroglioma NOS                |                                                                          |             
      Meninges, Granular Cell Tumor        |                                                                          |             
          Malignant                        |                                                                          |             
      Meninges, Granular Cell Tumor Benign |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 6| 2| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 7| 6| 7| 2| 2| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 3| 5| 5| 5| 5| 3| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Renal Tubule, Carcinoma              |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X                                         X           X        X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 6| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   5        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Mesothelioma Malignant               |                                                                          |          2 |
      Osteosarcoma, Metastatic             |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |   2        |
      Acinar Cell, Adenoma                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |   5        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Complex             |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |   2        |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |   9        |
      Pars Distalis, Adenoma               |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
      C-Cell, Adenoma                      |                                                                          |          5 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   8        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 6| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  44        |
      Mesothelioma Malignant               |                                                                          |          2 |
      Bilateral, Interstitial Cell, Adenoma|                                                                          |         41 |
      Interstitial Cell, Adenoma           |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   9        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          2 |
      Mesenteric, Leukemia Mononuclear     |                                                                          |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |   3        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  48        |
      Hemangioma                           |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         10 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  44        |
      Fibroadenoma                         |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  13        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Fibroma                              |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          3 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |   4        |
      Oligodendroglioma NOS                |                                                                          |          1 |
      Meninges, Granular Cell Tumor        |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 6| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Meninges, Granular Cell Tumor Benign |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |   3        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |         10 |
      Mesothelioma Malignant               |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  72                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|             
                                           | 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                  +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                  +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                  +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                  +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                  +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +                 +           +        +  +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                  +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +                 +           +        +  +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                  +                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |    X  X                    X        X        X  X  X              X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +                    +                                         +   |             
      Fibrosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                  A                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                  +                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                  +                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                  +                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                  +  +                                    |             
      Fibrosarcoma, Metastatic, Skin       |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +                             +                    +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                  +                                       |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +                             +                    +                  |             
      Ganglioneuroma                       |                                                                          |             
      Pheochromocytoma Benign              |                                                       X                  |             
      Bilateral, Pheochromocytoma Benign   |    X                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                  A                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                  +                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +        +        +  +  +  +  +                       +        +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Pars Distalis, Adenoma               |          X        X           X     X                          X        X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |             X                                                        X   |             
      C-Cell, Carcinoma                    |    X                                                                     |             
      Follicular Cell, Adenoma             |                   X                                                      |             
      Follicular Cell, Carcinoma           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|             
                                           | 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                  +                          +            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +           +  +              +                     |             
      Adenoma                              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                |                               +  +                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X     X  X     X  X  X  X  X  X  X     X  X  X  X  X  X|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                  +                                       |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +                 +        +            |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mesenteric, Leukemia Mononuclear     |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                    X                     |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                  +                                       |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                    X        X        X  X  X              X     X|             
      Osteosarcoma, Metastatic, Bone Marrow|                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                  +                                       |             
      Fibrosarcoma, Metastatic, Skin       |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +     +        +        +     +  +                 +  +     +   |             
      Adenoma                              |                                        X                                 |             
      Squamous Cell Papilloma              |                                        X                             X   |             
      Subcutaneous Tissue, Fibroma         |                X                                            X            |             
      Subcutaneous Tissue, Fibrosarcoma    |                                  X                                       |             
      Subcutaneous Tissue, Myxoma          | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|             
                                           | 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +                                       |             
      Astrocytoma NOS                      |                               X                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                  +           +                           |             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
      Fibrosarcoma, Metastatic, Skin       |                                  X                                       |             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic             |                                                                          |             
      Osteosarcoma, Metastatic, Bone Marrow|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                  +                                       |             
      Basosquamous Tumor Benign            |                                  X                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Squamous Cell Papilloma       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                    X        X        X  X  X              X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|             
                                           | 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                   +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                   +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                 X                        |             
      Leukemia Mononuclear                 | X     X  X                 X     X  X  X  X  X           X  X     X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Fibrosarcoma                         |                                                 X                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                          +               |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +                                                     +        +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +                                                                     |             
      Carcinoma                            |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                          +        +  +   |             
      Ganglioneuroma                       |                                                                   X      |             
      Pheochromocytoma Benign              |                                                                      X   |             
      Bilateral, Pheochromocytoma Benign   |                                                          X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +           +  +        +     +        +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |             X              X        X     X        X                    X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |       X                                X                 X     X         |             
      C-Cell, Carcinoma                    |             X                       X                                    |             
      Follicular Cell, Adenoma             |                                                                X         |             
      Follicular Cell, Carcinoma           |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|             
                                           | 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
      Sarcoma                              |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                             +              +     +        +|             
      Adenoma                              |             X                             X              X     X         |             
                                            __________________________________________________________________________|             
   Prostate                                |                                                             +            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                           +                 +            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X     X     X   |             
      Interstitial Cell, Adenoma           |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                       +                  |             
      Sarcoma                              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                   +           +           +            |             
      Mediastinal, Leukemia Mononuclear    | X                                                           X            |             
      Mesenteric, Leukemia Mononuclear     | X                                                           X            |             
      Pancreatic, Leukemia Mononuclear     |                                                             X            |             
      Renal, Leukemia Mononuclear          |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                     +                                    |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X                 X     X  X  X  X  X           X  X     X     X|             
      Osteosarcoma, Metastatic, Bone Marrow|                                                       X                  |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  I|             
      Fibroadenoma                         |          X                                                        X      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                +           +     +                                      +|             
      Adenoma                              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                         X|             
      Subcutaneous Tissue, Fibrosarcoma    |                X                                                         |             
      Subcutaneous Tissue, Myxoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|             
                                           | 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                              +                           |             
      Astrocytoma NOS                      |                                                                          |             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                             +              +        +                  |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Leukemia Mononuclear                 | X                                                                        |             
      Osteosarcoma, Metastatic             |                               X                                          |             
      Osteosarcoma, Metastatic, Bone Marrow|                                                       X                  |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
      Basosquamous Tumor Benign            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                                       |             
      Pinna, Squamous Cell Papilloma       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X                 X     X  X  X  X  X           X  X     X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         22 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Fibrosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |   3        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |   2        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |   6        |
      Ganglioneuroma                       |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          2 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               |                                                                          |         12 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Adenoma                      |                                                                          |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  79                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Carcinoma                    |                                                                          |          3 |
      Follicular Cell, Adenoma             |                                                                          |          2 |
      Follicular Cell, Carcinoma           |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   9        |
      Adenoma                              |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  44        |
      Bilateral, Interstitial Cell, Adenoma|                                                                          |         43 |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |   2        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   7        |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          2 |
      Mesenteric, Leukemia Mononuclear     |                                                                          |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |         22 |
      Osteosarcoma, Metastatic, Bone Marrow|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |   1        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  46        |
      Fibroadenoma                         |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  14        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  80                                                               
NTP Experiment-Test: 05021-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 08:49:39  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          3 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          2 |
      Subcutaneous Tissue, Myxoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |   3        |
      Astrocytoma NOS                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |   6        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Osteosarcoma, Metastatic             |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone Marrow|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |   1        |
      Basosquamous Tumor Benign            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Pinna, Squamous Cell Papilloma       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                                                          |  50        |
      Leukemia Mononuclear                 |                                                                          |         22 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  81                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------