National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2715

TDMS Study 05021-03 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         CI PIGMENT RED 23


NTP Experiment-Test: 05021-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: DOSED FEED                                                                                                 Time: 21:10:50




       Facility:  Southern Research Institute

       Chemical CAS #:  6471-49-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05021-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          18           11           14            8                                     
    Dead                                               3            5            3            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           34           33           40                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)                      (1)          (50)                                   
      Fibrosarcoma, Metastatic, Uterus                                           1 (100%)                                           
   Liver                                              (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                    1 (2%)       1 (2%)                                
      Fibrosarcoma, Metastatic, Uterus                                           1 (2%)                                             
   Mesentery                                          (4)          (2)          (7)          (5)                                    
      Carcinoma                                                                               1 (20%)                               
      Carcinoma, Metastatic, Ovary                                               1 (14%)                                            
      Fibrosarcoma, Metastatic, Uterus                                           1 (14%)                                            
      Sarcoma                                          1 (25%)                                1 (20%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinar Cell, Adenoma                                          2 (4%)                                                          
   Stomach, Forestomach                               (50)         (2)                       (50)                                   
      Leiomyosarcoma                                                                          1 (2%)                                
   Tongue                                                          (1)                       (1)                                    
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (1)                       (50)                                   
      Adenoma                                          2 (4%)                                 2 (4%)                                
      Carcinoma                                                     1 (100%)                                                        
   Adrenal Gland, Medulla                             (49)         (1)          (1)          (50)                                   
      Pheochromocytoma Malignant                       1 (2%)       1 (100%)     1 (100%)                                           
      Pheochromocytoma Benign                          1 (2%)                                 6 (12%)                               
                                                             Page   2                                                               
NTP Experiment-Test: 05021-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Bilateral, Pheochromocytoma Benign               3 (6%)                                                                       
   Islets, Pancreatic                                 (50)         (49)         (49)         (50)                                   
      Adenoma                                                       2 (4%)       1 (2%)       3 (6%)                                
      Carcinoma                                                                               1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          29 (58%)     23 (46%)     28 (56%)     18 (36%)                               
      Pars Distalis, Carcinoma                                      2 (4%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)       1 (2%)                                             
      C-Cell, Adenoma                                  5 (10%)      4 (8%)       4 (8%)       2 (4%)                                
      C-Cell, Carcinoma                                1 (2%)                    4 (8%)       3 (6%)                                
      Follicular Cell, Adenoma                                      1 (2%)                    3 (6%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
      Mediastinum, Myxoma                                                        1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (48)         (47)         (49)                                   
      Adenoma                                          5 (11%)      4 (8%)       3 (6%)       2 (4%)                                
      Carcinoma                                        3 (6%)                    1 (2%)                                             
   Ovary                                              (50)         (4)          (1)          (50)                                   
      Carcinoma                                                                  1 (100%)                                           
      Granulosa Cell Tumor NOS                                      1 (25%)                                                         
      Granulosa Cell Tumor Benign                                                             1 (2%)                                
      Thecoma NOS                                                   2 (50%)                                                         
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Ovary                                               1 (2%)                                             
      Fibrosarcoma                                                               1 (2%)                                             
      Leiomyoma                                                                  1 (2%)                                             
      Cervix, Sarcoma Stromal                                       1 (2%)                                                          
      Cervix, Endometrium, Polyp Stromal                                         1 (2%)                                             
      Endometrium, Polyp Stromal                       7 (14%)      4 (8%)       7 (14%)     13 (26%)                               
      Endometrium, Sarcoma Stromal                     1 (2%)       1 (2%)       1 (2%)                                             
   Vagina                                             (8)                       (1)          (4)                                    
      Fibrosarcoma                                     1 (13%)                                                                      
      Leiomyosarcoma                                   1 (13%)                                                                      
      Sarcoma                                                                    1 (100%)                                           
      Schwannoma Malignant                             1 (13%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05021-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (1)          (1)          (50)                                   
   Lymph Node                                         (50)         (2)          (2)          (50)                                   
      Lumbar, Carcinoma, Metastatic, Ovary                                       1 (50%)                                            
      Renal, Carcinoma, Metastatic, Ovary                                        1 (50%)                                            
   Lymph Node, Mandibular                             (50)                      (1)          (50)                                   
   Spleen                                             (50)         (50)         (49)         (50)                                   
      Fibrosarcoma, Metastatic, Uterus                                           1 (2%)                                             
      Hemangioma                                                                              1 (2%)                                
   Thymus                                             (49)                                   (48)                                   
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (38)         (32)         (50)                                   
      Adenoma                                                       2 (5%)       2 (6%)       1 (2%)                                
      Carcinoma                                        1 (2%)       2 (5%)                                                          
      Fibroadenoma                                    23 (46%)     24 (63%)     14 (44%)     19 (38%)                               
   Skin                                               (50)         (8)          (2)          (49)                                   
      Basal Cell Carcinoma                                          1 (13%)                                                         
      Keratoacanthoma                                  1 (2%)                                 1 (2%)                                
      Sebaceous Gland, Carcinoma                                                 1 (50%)                                            
      Subcutaneous Tissue, Fibroma                                  1 (13%)                                                         
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Tail, Hemangiosarcoma                                         1 (13%)                                                         
      Tail, Squamous Cell Papilloma                                 2 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (5)          (3)          (50)                                   
      Astrocytoma NOS                                               1 (20%)                   3 (6%)                                
      Glioma NOS                                       1 (2%)       1 (20%)                                                         
      Meningioma Malignant                                                                    1 (2%)                                
      Oligodendroglioma NOS                            1 (2%)                                                                       
      Choroid Plexus, Meningioma Malignant,                                                                                         
          Metastatic, Brain                                                                   1 (2%)                                
      Meninges, Granular Cell Tumor Benign             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05021-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (4)          (8)          (50)                                   
      Alveolar/Bronchiolar Adenoma                                  1 (25%)      1 (13%)                                            
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (25%)                                                         
      Carcinoma, Metastatic, Ovary                                               1 (13%)                                            
      Carcinoma, Metastatic, Skin                                                1 (13%)                                            
      Fibrosarcoma, Metastatic, Uterus                                           1 (13%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Pinna, Squamous Cell Papilloma                                             1 (100%)                                           
   Zymbal's Gland                                                  (2)          (1)                                                 
      Adenoma                                                       2 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (45)         (44)         (50)                                   
      Renal Tubule, Adenoma                                                                   1 (2%)                                
   Urinary Bladder                                    (50)         (2)                       (50)                                   
      Papilloma                                                     1 (50%)                                                         
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            14 (28%)      7 (14%)      3 (6%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05021-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          48          44          44                                       
     Total Primary Neoplasms                          110          98          81          90                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          43          41          41                                       
     Total Benign Neoplasms                            80          75          67          74                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          15          14          10                                       
     Total Malignant Neoplasms                         28          18          14          13                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      3           1                                       
     Total Metastatic Neoplasm                                                 11           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  2           5                       3                                       
     Total Uncertain Neoplasms                          2           5                       3                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05021-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10            9                                     
  Early Deaths                                                                                                                      
    Moribund                                          24           14           11           11                                     
    Dead                                               4            6            3            5                                     
    Moribund Sacrifice                                              1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           29           36           35                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (1)                       (50)                                   
      Mixed Tumor Malignant, Metastatic, Salivary                                                                                   
          Glands                                                                              1 (2%)                                
   Intestine Large, Rectum                            (50)         (1)                       (50)                                   
   Intestine Small, Ileum                             (50)         (7)          (17)         (50)                                   
   Intestine Small, Jejunum                           (50)         (1)          (5)          (50)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
      Carcinoma                                                                  1 (20%)                                            
      Leiomyoma                                        1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                             1 (2%)                                 1 (2%)                                
      Hepatocellular Carcinoma                         1 (2%)                                 1 (2%)                                
      Hepatocellular Adenoma                           2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
   Mesentery                                          (11)         (5)          (7)          (11)                                   
      Fibrosarcoma                                                  1 (20%)                                                         
      Fibrous Histiocytoma                             1 (9%)                                                                       
      Osteosarcoma, Metastatic                                                   1 (14%)                                            
      Sarcoma                                                                    1 (14%)                                            
   Pancreas                                           (50)                      (2)          (49)                                   
      Carcinoma, Metastatic, Stomach                                                          1 (2%)                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Acinar Cell, Adenoma                             2 (4%)                    1 (50%)      1 (2%)                                
   Salivary Glands                                    (49)         (1)                       (50)                                   
      Mixed Tumor Malignant                                                                   1 (2%)                                
   Stomach, Forestomach                               (50)         (1)                       (50)                                   
      Carcinoma, Metastatic, Stomach                                                          1 (2%)                                
   Stomach, Glandular                                 (50)         (1)                       (50)                                   
      Carcinoma                                                                               1 (2%)                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05021-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (3)          (5)          (50)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (33%)                                                         
      Mixed Tumor Malignant, Metastatic, Salivary                                                                                   
          Glands                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (2)                       (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                     1 (50%)                                                         
   Adrenal Gland, Medulla                             (48)         (6)          (5)          (50)                                   
      Ganglioneuroma                                                1 (17%)                                                         
      Pheochromocytoma Malignant                       1 (2%)                    1 (20%)      1 (2%)                                
      Pheochromocytoma Complex                                                   1 (20%)      1 (2%)                                
      Pheochromocytoma Benign                         18 (38%)      2 (33%)      1 (20%)     15 (30%)                               
      Bilateral, Pheochromocytoma Benign              12 (25%)      2 (33%)      2 (40%)     11 (22%)                               
   Islets, Pancreatic                                 (50)                      (2)          (49)                                   
      Adenoma                                          1 (2%)                                 3 (6%)                                
      Carcinoma                                        1 (2%)                    2 (100%)     1 (2%)                                
   Parathyroid Gland                                  (49)         (1)          (1)          (49)                                   
      Adenoma                                          2 (4%)                                 2 (4%)                                
      Mixed Tumor Malignant, Metastatic, Salivary                                                                                   
          Glands                                                                              1 (2%)                                
   Pituitary Gland                                    (50)         (16)         (9)          (49)                                   
      Pars Distalis, Adenoma                          12 (24%)     12 (75%)      8 (89%)      8 (16%)                               
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
      Pars Nervosa, Adenoma                                                                   1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Mixed Tumor Malignant, Metastatic, Salivary                                                                                   
          Glands                                                                              1 (2%)                                
      C-Cell, Adenoma                                  3 (6%)       6 (12%)      5 (10%)      7 (14%)                               
      C-Cell, Carcinoma                                1 (2%)       3 (6%)       1 (2%)       3 (6%)                                
      Follicular Cell, Adenoma                         2 (4%)       2 (4%)                    1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)       2 (4%)       1 (2%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)          (1)                                                              
      Fibroma                                          2 (50%)                                                                      
      Liposarcoma                                      1 (25%)                                                                      
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05021-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (2)                       (48)                                   
      Fibrous Histiocytoma                             1 (2%)                                                                       
   Preputial Gland                                    (49)         (9)          (8)          (49)                                   
      Adenoma                                          3 (6%)       5 (56%)      8 (100%)     7 (14%)                               
      Carcinoma                                        2 (4%)                                 1 (2%)                                
   Prostate                                           (50)         (3)          (2)          (49)                                   
      Carcinoma, Metastatic, Stomach                                                          1 (2%)                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
   Seminal Vesicle                                    (50)         (2)                       (49)                                   
      Carcinoma, Metastatic, Stomach                                                          1 (2%)                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
   Testes                                             (50)         (44)         (44)         (49)                                   
      Bilateral, Interstitial Cell, Adenoma           42 (84%)     43 (98%)     41 (93%)     44 (90%)                               
      Interstitial Cell, Adenoma                       6 (12%)      1 (2%)       3 (7%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (5)                                                                           
   Bone Marrow                                        (50)         (2)                       (50)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Sarcoma                                                       1 (50%)                                                         
   Lymph Node                                         (49)         (7)          (9)          (48)                                   
      Bronchial, Carcinoma, Metastatic, Stomach                                               1 (2%)                                
      Iliac, Fibrous Histiocytoma                      1 (2%)                                                                       
      Mesenteric, Carcinoma, Metastatic, Stomach                                              1 (2%)                                
      Mesenteric, Fibrous Histiocytoma                 1 (2%)                                                                       
      Pancreatic, Carcinoma, Metastatic, Islets,                                                                                    
           Pancreatic                                  1 (2%)                                                                       
      Renal, Fibrous Histiocytoma                      1 (2%)                                                                       
   Lymph Node, Mandibular                             (49)         (2)          (3)          (48)                                   
   Spleen                                             (50)         (50)         (48)         (50)                                   
      Fibrous Histiocytoma                             1 (2%)                                 1 (2%)                                
      Hemangioma                                                                 1 (2%)                                             
      Osteosarcoma, Metastatic, Bone Marrow                         1 (2%)                                                          
   Thymus                                             (49)         (1)                       (46)                                   
      Carcinoma, Metastatic, Stomach                                                          1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                                1 (100%)                                                        
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Thymoma Benign                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05021-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (46)         (44)         (43)                                   
      Fibroadenoma                                     2 (4%)       2 (4%)       2 (5%)       3 (7%)                                
      Fibroma                                                                                 2 (5%)                                
   Skin                                               (50)         (14)         (13)         (50)                                   
      Adenoma                                                       1 (7%)                                                          
      Basal Cell Adenoma                               1 (2%)                    1 (8%)                                             
      Basal Cell Carcinoma                                                                    2 (4%)                                
      Fibroma                                                                    1 (8%)                                             
      Keratoacanthoma                                  1 (2%)                    3 (23%)      2 (4%)                                
      Squamous Cell Carcinoma                          1 (2%)                    1 (8%)                                             
      Squamous Cell Papilloma                          1 (2%)       2 (14%)                   1 (2%)                                
      Face, Keratoacanthoma                                                                   1 (2%)                                
      Face, Neurofibroma                                                                      1 (2%)                                
      Sebaceous Gland, Adenoma                                                                1 (2%)                                
      Subcutaneous Tissue, Fibroma                                  3 (21%)      4 (31%)      2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma                             2 (14%)                                                         
      Subcutaneous Tissue, Fibrous Histiocytoma                                               1 (2%)                                
      Subcutaneous Tissue, Lipoma                                                             1 (2%)                                
      Subcutaneous Tissue, Myxoma                                   1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                                           (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (3)          (4)          (50)                                   
      Astrocytoma NOS                                               1 (33%)                   2 (4%)                                
      Oligodendroglioma NOS                                                      1 (25%)                                            
      Meninges, Granular Cell Tumor Malignant                                    1 (25%)                                            
      Meninges, Granular Cell Tumor Benign             1 (2%)                    1 (25%)                                            
      Meninges, Mixed Tumor Malignant, Metastatic,                                                                                  
           Salivary Glands                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (6)          (3)          (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (17%)                   1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                                          1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                                       1 (33%)                                            
      Fibrosarcoma, Metastatic, Skin                                1 (17%)                                                         
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Osteosarcoma, Metastatic                                      1 (17%)                                                         
                                                             Page  10                                                               
NTP Experiment-Test: 05021-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Osteosarcoma, Metastatic, Bone Marrow                         1 (17%)                                                         
      Squamous Cell Carcinoma, Metastatic, Skin                                  1 (33%)                                            
   Nose                                               (50)         (1)          (1)          (49)                                   
      Basosquamous Tumor Benign                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                       (1)                                    
      Pinna, Neurofibroma                                                                     1 (100%)                              
      Pinna, Squamous Cell Papilloma                                1 (100%)                                                        
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (48)         (50)         (50)                                   
      Renal Tubule, Adenoma                                                                   2 (4%)                                
      Renal Tubule, Carcinoma                                                    1 (2%)       1 (2%)                                
   Urinary Bladder                                    (50)         (1)                       (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            28 (56%)     22 (44%)     10 (20%)      4 (8%)                                
      Lymphoma Malignant Histiocytic                                                          1 (2%)                                
      Mesothelioma Malignant                           2 (4%)                    3 (6%)       3 (6%)                                
      Mesothelioma NOS                                 2 (4%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05021-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 21:10:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     1.0%         2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          48          50                                       
     Total Primary Neoplasms                          172         121         108         157                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          48          48          49                                       
     Total Benign Neoplasms                           117          87          83         123                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          30          21          22                                       
     Total Malignant Neoplasms                         53          33          24          30                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3           3           2                                       
     Total Metastatic Neoplasm                          2           6           3          12                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  2           1           1           4                                       
     Total Uncertain Neoplasms                          6           1           1          13                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.