National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2719

TDMS Study 05021-03 Pathology Tables

NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97
Route: DOSED FEED                                                                                                 Time: 11:48:44




       Facility:  Southern Research Institute

       Chemical CAS #:  6471-49-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|             
                             DAY ON TEST   | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|             
                                           | 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                                           X  X        X  X     X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X     X     X                 X                 X  X           X      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                  3     1  1                          1  1|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                      3                                                   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |          X  X     X  X  X  X  X  X     X  X  X  X  X  X  X     X     X  X|             
      Bile Stasis                          |                                           2                              |             
      Clear Cell Focus                     |                                                          X               |             
      Congestion                           |                            2                                             |             
      Hematopoietic Cell Proliferation     |                   2                                2     1               |             
      Hepatodiaphragmatic Nodule           |       X                       X              X                 X  X      |             
      Hyperplasia                          |                         2                             1                  |             
      Hypertrophy, Focal                   |                                              2                           |             
      Infiltration Cellular, Lymphocyte    |                                                 1                        |             
      Inflammation, Acute                  |                      2                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                            1  2        1              2        3         |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                               3                             3           1|             
      Bile Duct, Hyperplasia               |                                                                         1|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +              +                 +                                 |             
      Fat, Necrosis, Focal                 |                      2                 2                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       | 1                 1                       2           1  1               |             
      Autolysis                            |                      3                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Ectasia                        | 2                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Inflammation, Chronic          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|             
                             DAY ON TEST   | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|             
                                           | 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       4                 2                                                |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |       3                 1     3                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |          1        2                 1     1              1  1            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       1  1  2     2  1     2  2  1  1  1  2  2  1  1  2  1  1  1  1  3  2|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     2                                    |             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |          1           1           1     1              1                 1|             
      Hypertrophy                          |                   1     1                    1           1               |             
      Vacuolization Cytoplasmic            |       2  2  2           1  3                          2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1  3                 1           1     1                       1  1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 1                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   2                                                      |             
      Pars Distalis, Cyst                  | 3  3        1        1                    2  1  1  3  2     1            |             
      Pars Distalis, Ectasia               |                            2           3  3                              |             
      Pars Distalis, Hyperplasia           |             2                          2  2     1                        |             
      Pars Distalis, Hypertrophy           |                                                    1                     |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                   1     2  2     1     2     3  1  1  2  3  1     1  2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|             
                             DAY ON TEST   | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|             
                                           | 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3                                2                             3|             
      Inflammation, Acute                  |                         1  1                 1                           |             
      Inflammation, Chronic                |                                     1                    2               |             
      Duct, Ectasia                        |                            3                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                  1                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                2                    2                             3      |             
      Inflammation, Acute                  |       1                                                                  |             
      Necrosis                             |             4                                                            |             
      Cervix, Inflammation, Acute          |          2                                                               |             
      Endometrium, Hyperplasia, Cystic     |                                                    2                     |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +  +                    +                       +     +            |             
      Inflammation, Acute                  |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                                      |             
      Hypoplasia                           |                            2     2                                       |             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                    1                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Congestion               |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          2           2   |             
      Hyperplasia                          |                      2                                            2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             1            |             
      Ectasia                              |                                                             2            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |       4           4                                3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                       2                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                                                    1  2           1      |             
      Duct, Ectasia                        |    2  3  2        1  1  3  3  2        1                          2  2  1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|             
                             DAY ON TEST   | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|             
                                           | 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                            2              3                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                         2     3     2                          3     2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         2|             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       1                                                              1   |             
      Alveolus, Mineralization             |                                                                          |             
      Epithelium, Alveolus, Hyperplasia    |                                                                1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                      X                                                   |             
      Mucosa, Inflammation, Chronic Active |                      2                 1                                 |             
      Nasolacrimal Duct, Cyst              |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Lens, Cataract                       |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hydronephrosis                       |                                                             2            |             
      Infarct                              |                                           3                              |             
      Mineralization                       |                   1                             1                 1      |             
      Nephropathy                          | 1  1  3  2  1     2  1  2  3  3  3  3  1  2  2  1  1  2  1  3  4  1  4  2|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            | 3                                                                        |             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                            X     X  X  X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            | 2                                                                        |             
      Inflammation, Acute                  |                1                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            | 4                                                                        |             
      Hyperplasia, Lymphoid                |       2     1           2                                1        3      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            | 4                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |          X        X  X  X  X     X  X     X  X  X     X  X  X     X  X  X|             
      Bile Stasis                          |                                                                          |             
      Clear Cell Focus                     |                            X                                             |             
      Congestion                           | 3                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |       X                          X                                       |             
      Hyperplasia                          |             1                                                            |             
      Hypertrophy, Focal                   |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                               3                                          |             
      Inflammation, Granulomatous          |          1           2           1        1              1  2     2  2  2|             
      Necrosis                             |                               4                                          |             
      Vacuolization Cytoplasmic            |    2           3              2  2        1                              |             
      Bile Duct, Hyperplasia               |                                                       1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                        |             
      Fat, Necrosis, Focal                 | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |    1                 2     1           1        1     1        2     1   |             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic                |          1                                1                              |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Inflammation, Chronic          |          1                                                               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3                                                                     |             
      Inflammation, Acute                  |                4                                                         |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                     1                                    |             
      Ulcer                                |    4                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                2                                                         |             
      Inflammation, Chronic                |    2                                                                     |             
      Mineralization                       |    4                    1        1  1        1  2        1  2     2  2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                                                     |             
      Mineralization                       |    3                                                                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  1  1  3  2  1  1  2     2        2  1  1  2  2  1  2  3     2  2  1  2|             
      Mineralization                       |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Ectasia                              |          2           1           2                                       |             
      Hyperplasia                          |                1                             1  1        2     1  1  1   |             
      Hypertrophy                          |                      1  1              1              1        1        1|             
      Vacuolization Cytoplasmic            |    3     1     1                 2        1                    1     2  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |          2  2        2              2     1                 1           2|             
      Pars Distalis, Ectasia               |                                              1        2                  |             
      Pars Distalis, Hyperplasia           |                      2              3     1           2           1      |             
      Pars Distalis, Hypertrophy           |             1        1                                                   |             
      Pars Intermedia, Cyst                |                                                       1                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    4     1  2  2  1     2  2        2  1  1  2  1  2  1  3     3  2  1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2              3                                             |             
      Inflammation, Acute                  |             3                    1                                       |             
      Inflammation, Chronic                |                                                                         1|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                           1                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       3                                                                  |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
      Cervix, Inflammation, Acute          |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                    1                     |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                             +  +  +      |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypoplasia                           |                                                                          |             
      Myelofibrosis                        |       1              1                                                   |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Congestion               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          1     2         |             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                            X                                             |             
      Hyperplasia                          |                                           1                              |             
      Duct, Ectasia                        |    2  3  2  1  2  1        2        1  3  1  2  2  2  2  2     2     2  1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    2           2  3     1              3           1     1     1         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3                    1                                                   |             
      Foreign Body                         |                               2                                          |             
      Inflammation, Acute                  |                               3                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       3                                3                                 |             
      Alveolus, Mineralization             |    1                                                                     |             
      Epithelium, Alveolus, Hyperplasia    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               3                                          |             
      Fungus                               |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                               3           1                              |             
      Nasolacrimal Duct, Cyst              |                                                    2                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                        1     1  1                    2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            | 3                                                                        |             
      Hydronephrosis                       |    3                                                                     |             
      Infarct                              |                                                                          |             
      Mineralization                       |                   1        1                                   1         |             
      Nephropathy                          | 4  4  1  1  1  4  2  2  1  3     1  2  3  3  3  3  3  2  3  1  2  3  2  3|             
      Renal Tubule, Hyperplasia            |    2           1                                                         |             
                                            __________________________________________________________________________|             
   Ureter                                  |    +                                                                     |             
      Inflammation, Chronic                |    1                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |     12     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |     10  1.6|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus, Multiple           |                                                                          |     34     |
      Bile Stasis                          |                                                                          |      1  2.0|
      Clear Cell Focus                     |                                                                          |      2     |
      Congestion                           |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.7|
      Hepatodiaphragmatic Nodule           |                                                                          |      7     |
      Hyperplasia                          |                                                                          |      3  1.3|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |     14  1.6|
      Necrosis                             |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |                                                                          |      8  2.1|
      Bile Duct, Hyperplasia               |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fat, Necrosis, Focal                 |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Atrophy, Focal                       |                                                                          |     13  1.2|
      Autolysis                            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Duct, Inflammation, Chronic          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      3  3.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      3  2.3|
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |     16  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |     42  1.6|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |      3  1.7|
      Hyperplasia                          |                                                                          |     13  1.1|
      Hypertrophy                          |                                                                          |     10  1.0|
      Vacuolization Cytoplasmic            |                                                                          |     14  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      7  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |     17  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Ectasia               |                                                                          |      5  2.2|
      Pars Distalis, Hyperplasia           |                                                                          |      9  1.8|
      Pars Distalis, Hypertrophy           |                                                                          |      3  1.0|
      Pars Intermedia, Cyst                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Hyperplasia                  |                                                                          |     33  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  47        |
      Hyperplasia                          |                                                                          |      5  2.6|
      Inflammation, Acute                  |                                                                          |      5  1.4|
      Inflammation, Chronic                |                                                                          |      3  1.3|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Follicle, Cyst                       |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Dilatation                           |                                                                          |      4  2.5|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  4.0|
      Cervix, Inflammation, Acute          |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   8        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypoplasia                           |                                                                          |      2  2.0|
      Myelofibrosis                        |                                                                          |      2  1.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Mesenteric, Congestion               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
      Congestion                           |                                                                          |      4  1.8|
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                                                                          |      1  1.0|
      Ectasia                              |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  49        |
      Cyst                                 |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
      Galactocele                          |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      4  1.3|
      Duct, Ectasia                        |                                                                          |     30  1.9|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Osteopetrosis                        |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Compression                          |                                                                          |     13  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      3  2.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      4  2.0|
      Alveolus, Mineralization             |                                                                          |      1  1.0|
      Epithelium, Alveolus, Hyperplasia    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Foreign Body                         |                                                                          |      1  3.0|
      Fungus                               |                                                                          |      1     |
      Mucosa, Inflammation, Chronic Active |                                                                          |      4  1.8|
      Nasolacrimal Duct, Cyst              |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Chronic                         |                                                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Hydronephrosis                       |                                                                          |      2  2.5|
      Infarct                              |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      6  1.0|
      Nephropathy                          |                                                                          |     48  2.2|
      Renal Tubule, Hyperplasia            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |    X                                   X           X                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                         1  2  1  2  2     2  2  3  2     2     2  2     2|             
      Pigmentation                         |                         1  2        1     1  1  1  2     1               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    1              2      |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |          X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |                                                 X                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |       X  X                                X  X                 X         |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Lymphocyte    |             1                                                            |             
      Inflammation, Acute                  |                      2                                            2      |             
      Inflammation, Chronic                |                               1                                          |             
      Inflammation, Granulomatous          |                            1              2  1     1           1         |             
      Necrosis                             | 1                                                                        |             
      Vacuolization Cytoplasmic            |                               3                                         1|             
      Bile Duct, Hyperplasia               |                                     1                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +           +           +               |             
      Fat, Necrosis, Focal                 |                                                          2               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |    1        1           1  1  1  1        2                       1     1|             
      Autolysis                            |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                            1        1                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Mineralization                       |                      2     1        1  1     2  1        3               |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
      Epithelium, Hyperplasia, Focal       |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1  1  1  1  1  1     1  1  2  1  1  1  3  2  3  1  2  2  1  1  2  1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2  2                          2                                          |             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |    1  2  1  2                    1  1                       2     1  1   |             
      Hypertrophy                          |          1                 1                 2        1                  |             
      Vacuolization Cytoplasmic            |    2                                3                          1         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                                          |             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                    2                     |             
      Pars Distalis, Cyst                  | 2  2  3  1                       1  1        1        1        1  2     1|             
      Pars Distalis, Ectasia               |                                  3                             2     1   |             
      Pars Distalis, Hemorrhage            |                      4                                                   |             
      Pars Distalis, Hyperplasia           |          1                    1        2  1                    2     1   |             
      Pars Distalis, Hypertrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1  1  1  1        1     3     1  1  1              1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                 2                        |             
      Inflammation, Acute                  |                               1                          2              1|             
      Inflammation, Chronic                |                            1                          2        1     1   |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                     1                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    3           1     2                                2                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +              +                                   +   |             
      Inflammation, Chronic                |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Myeloid Cell, Hyperplasia            | 2                 1  2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia                | 2                                                                        |             
      Mediastinal, Congestion              | 2                                                                        |             
      Mesenteric, Congestion               | 1                                                                        |             
      Mesenteric, Pigmentation             |          2        2                    3  1  2  1                        |             
      Pancreatic, Ectasia                  |                      2                                                   |             
      Pancreatic, Hyperplasia              |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                                                        |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Fibrosis                             |                                  2                                       |             
      Hematopoietic Cell Proliferation     | 3                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                   3  2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Medulla, Hyperplasia                 |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        1        2                    1  1|             
      Duct, Ectasia                        | 2        1  1        1           2     1                    1        1   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
      Foreign Body                         |                                                       2                  |             
      Inflammation, Chronic                |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   2  3     2                                3            |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                1                       1                          1  1   |             
      Epithelium, Alveolus, Hyperplasia    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |    2                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Lens, Cataract                       |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Infarct                              |                                                                          |             
      Mineralization                       |                1                             1  1  1           1         |             
      Nephropathy                          | 1  1  1  1  3  1     1  1  3  2  1  1  2  3     2  2  3  2  3  2  2  2  1|             
      Cortex, Cyst                         |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                 3           1            |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Degeneration                     | 3                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    2                                         3                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    2                                         3                           |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    2                                         3                           |             
      Parasite Metazoan                    |                X  X  X  X                          X                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    2                                         3                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    3                                         3                           |             
      Hyperplasia, Lymphoid                | 3     2  1  1  1  2                 2     2     3     3  3           2  2|             
      Pigmentation                         |                                     1                    2               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    4                                         3                           |             
      Hyperplasia, Lymphoid                |             2                                         2                  |             
      Necrosis, Focal                      |                                           3                              |             
      Pigmentation                         |                                           1                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | X     X  X     X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |    4                                                                     |             
      Hepatodiaphragmatic Nodule           |    X     X                 X        X                                    |             
      Hyperplasia                          |                                                       2     2            |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |             2  1  2     1     1  1                    1  1     2  1  2   |             
      Necrosis                             |    3                                                                     |             
      Vacuolization Cytoplasmic            |             1  1     1                                                   |             
      Bile Duct, Hyperplasia               |                                           1     1                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                 +                                 |             
      Fat, Necrosis, Focal                 |                      2                 2                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |          1        1                 1     1           1  1     1  2  1  2|             
      Autolysis                            |    2                                         4                           |             
      Inflammation, Acute                  |                1                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1                                          |             
      Inflammation, Chronic                |                               2                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              3                           |             
      Mineralization                       |             1  2  2  1           2  2  1  1     1  1  2  1     1  2  1   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1  1  2  2  2  1  2  1  1  1  1  1  1  2  1  1  1  1     1  2  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |          1              1        1              2                       2|             
      Hyperplasia                          | 1     1                 1        1  1     2                 3     1  1   |             
      Hypertrophy                          |          1           1     1           2              2  2               |             
      Vacuolization Cytoplasmic            |             2     1  1  1                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                1                                                         |             
      Hyperplasia                          |    2           1                                      3                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                           2              2               |             
      Autolysis                            |                                              4                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  | 2     1  2        1        3        1  1        1  1     1              1|             
      Pars Distalis, Ectasia               |                                  1                       1               |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |          2                       1                       1        2     3|             
      Pars Distalis, Hypertrophy           |       1                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1  1           1  1  3     1     1  1     2  3     1  1     2  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                1                                      1     1            |             
      Duct, Cyst                           |                                                                1         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |          +                                                               |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              4                           |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia                |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mesenteric, Congestion               |                                                                          |             
      Mesenteric, Pigmentation             |                               2  2        2                              |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                1         |             
      Hyperplasia, Re Cell                 |                                                                      1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                      2                                                   |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |    3                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 |                                                 1                        |             
      Medulla, Hyperplasia                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Duct, Ectasia                        |             2        2     2  1  2           1  1           3  2        1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        | 1     2                                2     2  1        2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               2                             2        2   |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1                                                                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                      1                 1                                 |             
      Epithelium, Alveolus, Hyperplasia    |             1                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          2  2           2                                                |             
      Fungus                               |                            X                             X               |             
      Mucosa, Inflammation, Chronic Active |          1  1           2  3                             1               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
      Lens, Cataract                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    3                                         4                           |             
      Infarct                              |                            2                                             |             
      Mineralization                       | 1                                               1                        |             
      Nephropathy                          | 1     2  2  3  2  1  3  2  1  2  1  1  3  1     2  2  3  2  3  1  2  2  3|             
      Cortex, Cyst                         |                                     1                                    |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Degeneration                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  2.5|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  2.5|
      Parasite Metazoan                    |                                                                          |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |     26  2.0|
      Pigmentation                         |                                                                          |     10  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  3.5|
      Hyperplasia, Lymphoid                |                                                                          |      4  1.8|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus, Multiple           |                                                                          |     43     |
      Clear Cell Focus                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      9     |
      Hyperplasia                          |                                                                          |      2  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Granulomatous          |                                                                          |     16  1.3|
      Necrosis                             |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      5  1.4|
      Bile Duct, Hyperplasia               |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Fat, Necrosis, Focal                 |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Atrophy, Focal                       |                                                                          |     19  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Autolysis                            |                                                                          |      2  3.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Atrophy                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |     22  1.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |     46  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Congestion                           |                                                                          |      3  2.0|
      Ectasia                              |                                                                          |      5  1.4|
      Hyperplasia                          |                                                                          |     18  1.3|
      Hypertrophy                          |                                                                          |     10  1.4|
      Vacuolization Cytoplasmic            |                                                                          |      7  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
      Atypia Cellular                      |                                                                          |      2  2.0|
      Autolysis                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |     22  1.4|
      Pars Distalis, Ectasia               |                                                                          |      5  1.6|
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia           |                                                                          |     11  1.5|
      Pars Distalis, Hypertrophy           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Hyperplasia                  |                                                                          |     24  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      3  1.3|
      Inflammation, Chronic                |                                                                          |      7  1.1|
      Duct, Cyst                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Follicle, Cyst                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Dilatation                           |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   4        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  4.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Inguinal, Hyperplasia                |                                                                          |      1  2.0|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mesenteric, Congestion               |                                                                          |      1  1.0|
      Mesenteric, Pigmentation             |                                                                          |      9  1.9|
      Pancreatic, Ectasia                  |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
      Congestion                           |                                                                          |      2  1.5|
      Hyperplasia, Re Cell                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  48        |
      Cyst                                 |                                                                          |      1  1.0|
      Medulla, Hyperplasia                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      4  1.3|
      Duct, Ectasia                        |                                                                          |     18  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Osteopetrosis                        |                                                                          |      7  1.7|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Compression                          |                                                                          |      7  2.3|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      6  1.0|
      Epithelium, Alveolus, Hyperplasia    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Foreign Body                         |                                                                          |      3  2.0|
      Fungus                               |                                                                          |      2     |
      Mucosa, Inflammation, Chronic Active |                                                                          |      5  1.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 8| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Lens, Cataract                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  3.5|
      Infarct                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      7  1.0|
      Nephropathy                          |                                                                          |     46  1.9|
      Cortex, Cyst                         |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |                                                                          |      2  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Degeneration                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 5| 7| 7| 5| 5| 6| 6| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 7| 3| 3| 6| 9| 6| 8| 3| 5| 0| 3| 3| 3| 9| 5| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 2| 5| 2| 2| 2| 4| 5| 2| 8| 2| 7| 1| 2| 2| 2| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +              +     +     +        +  +  +        +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +              +     +     +        +     +        +  +     +|             
      Hyperplasia, Lymphoid                | 3        2  2              3     2     4        2     2        3  3     3|             
      Pigmentation                         | 1                                                                 1     1|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +                                         +                     |             
      Hyperplasia, Lymphoid                |          1                                         2                     |             
      Pigmentation                         | 1                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | X           X     X        X     X  X  X  X  X  X  X  X  X     X  X  X  X|             
      Ectasia                              |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X                          X        X  X            |             
      Inflammation, Chronic                |                                           1              1               |             
      Inflammation, Granulomatous          |                                                             3            |             
      Leukocytosis                         |    2                                                                     |             
      Vacuolization Cytoplasmic            |                         4        2  1                                   1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                +              +                       +                 +|             
      Fat, Necrosis, Focal                 |                                                       2                 2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |          2     1              1        1     1                 1         |             
      Atrophy                              |                                                                          |             
      Ectopic Liver                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                   +                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                   +                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                              1                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                       2              2   |             
      Pars Distalis, Ectasia               |                                                                          |             
      Pars Distalis, Hyperplasia           |                            2              1  1                       2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     1     1                    1  1  1  1  1     2     1     1  1  2  2|             
      Follicle, Cyst                       |                                                    1                     |             
      Follicular Cell, Hyperplasia         |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 5| 7| 7| 5| 5| 6| 6| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 7| 3| 3| 6| 9| 6| 8| 3| 5| 0| 3| 3| 3| 9| 5| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 2| 5| 2| 2| 2| 4| 5| 2| 8| 2| 7| 1| 2| 2| 2| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                                                 2                        |             
      Inflammation, Acute                  | 2                       2                       2                        |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Ectasia                        |                                           3                              |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    4                     |             
      Dilatation                           |                                                                      3   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                +                                                         |             
      Polychromasia                        |                3                                                         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hematopoietic Cell Proliferation     |                3                                                     3   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |    3                                                                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +  +     +     +        +  +  +  +  +  +        +  +  +  +     +|             
      Hyperplasia                          |          2  2                             1                    2         |             
      Duct, Ectasia                        |                   1     3        3  2  2  1     3        2  2     3     2|             
                                            __________________________________________________________________________|             
   Skin                                    |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                         +           +           +        +              +|             
      Osteopetrosis                        |                         2           2           2        2              1|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Cyst                                 |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                         +                                   +            |             
      Compression                          |                         3                                   2            |             
      Gliosis, Focal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 5| 7| 7| 5| 5| 6| 6| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 7| 3| 3| 6| 9| 6| 8| 3| 5| 0| 3| 3| 3| 9| 5| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 2| 5| 2| 2| 2| 4| 5| 2| 8| 2| 7| 1| 2| 2| 2| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +           +  +           +                          +               |             
      Congestion                           |                   4                                                      |             
      Hemorrhage                           |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Lens, Cataract                       |    3                                                                     |             
      Retina, Degeneration                 |    4                                                                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hydronephrosis                       |                               3                                          |             
      Nephropathy                          | 2     1  3  2  1  1     3  3     3  2  3  2     3  3  2  1  2  2  3  1  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 4| 1| 3| 3| 3|             
                                           | 1| 5| 5| 5| 5| 5| 2| 2| 5| 5| 5| 5| 5| 5| 5| 8| 3| 5| 5| 5| 6| 2| 2| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +        +     +     +  +  +     +           +  +     +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +        +     +     +  +  +     +           +  +     +  +     +|             
      Hyperplasia, Lymphoid                | 1        3        3     2     2  2  3     2           3  2     2  3     3|             
      Pigmentation                         |                         1                                      1        3|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                         +|             
      Hyperplasia, Lymphoid                |                                                                         1|             
      Pigmentation                         |                                                                         2|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |    X  X  X  X  X     X  X  X  X  X  X  X  X  X  X     X  X  X     X     X|             
      Ectasia                              |                1                                                         |             
      Hepatodiaphragmatic Nodule           |             X                 X                       X        X         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |          2  1        2     2           1     1  1        1     1     1   |             
      Leukocytosis                         |                                                                          |             
      Vacuolization Cytoplasmic            | 3                 1                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +        +                             +   |             
      Fat, Necrosis, Focal                 |                               2        2                             2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |          1     1  1        1              3                              |             
      Atrophy                              |    1                                                              1      |             
      Ectopic Liver                        |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                       2                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                         1     2              2  1  2                     |             
      Pars Distalis, Ectasia               | 2                                   1           2                        |             
      Pars Distalis, Hyperplasia           |    3                 2        2     1           1  1                    3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1  3     1     2  1  2  1        2  2  4  1  4  3  1  4     1  1      |             
      Follicle, Cyst                       |                                                                         2|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 4| 1| 3| 3| 3|             
                                           | 1| 5| 5| 5| 5| 5| 2| 2| 5| 5| 5| 5| 5| 5| 5| 8| 3| 5| 5| 5| 6| 2| 2| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +|             
      Atrophy                              |                                  2                                       |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                            3                             2               |             
      Inflammation, Chronic                |             1                                   1                        |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Dilatation                           |                                              2                           |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Polychromasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +                                                   |             
      Hemorrhage                           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                   3              2                                4      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +     +  +     +  +     +  +  +  +  +  +  +        +        +   |             
      Hyperplasia                          |                            2                                             |             
      Duct, Ectasia                        | 2     3        3  3     3  2     3        3     3  1                 3   |             
                                            __________________________________________________________________________|             
   Skin                                    |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                   +              +  +              +  +                  |             
      Osteopetrosis                        |                   3              2  4              4  3                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +                                                         |             
      Compression                          |                2                                                         |             
      Gliosis, Focal                       |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 4| 1| 3| 3| 3|             
                                           | 1| 5| 5| 5| 5| 5| 2| 2| 5| 5| 5| 5| 5| 5| 5| 8| 3| 5| 5| 5| 6| 2| 2| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +        +                                                      |             
      Congestion                           | 2                                                                        |             
      Hemorrhage                           |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |    2                       1                             2               |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          |    3  2  3  2  2  3  2  3  2  3  2  3     2  1  2  2  2  1     2  2  3  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 9| 9| 9| 8| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  24        |
      Hyperplasia, Lymphoid                |                                                                          |     24  2.5|
      Pigmentation                         |                                                                          |      6  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   4        |
      Hyperplasia, Lymphoid                |                                                                          |      3  1.3|
      Pigmentation                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus, Multiple           |                                                                          |     37     |
      Ectasia                              |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      8     |
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Inflammation, Granulomatous          |                                                                          |     11  1.5|
      Leukocytosis                         |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Fat, Necrosis, Focal                 |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Atrophy, Focal                       |                                                                          |     11  1.3|
      Atrophy                              |                                                                          |      2  1.0|
      Ectopic Liver                        |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
      Atypia Cellular                      |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Cyst                  |                                                                          |      7  1.7|
      Pars Distalis, Ectasia               |                                                                          |      3  1.7|
      Pars Distalis, Hyperplasia           |                                                                          |     11  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Hyperplasia                  |                                                                          |     32  1.6|
      Follicle, Cyst                       |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 9| 9| 9| 8| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  47        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      5  2.2|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Dilatation                           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Polychromasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  32        |
      Hyperplasia                          |                                                                          |      5  1.8|
      Duct, Ectasia                        |                                                                          |     22  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 9| 9| 9| 8| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  10        |
      Osteopetrosis                        |                                                                          |     10  2.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |   3        |
      Compression                          |                                                                          |      3  2.3|
      Gliosis, Focal                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |   8        |
      Congestion                           |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  44        |
      Congestion                           |                                                                          |      3  1.7|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Nephropathy                          |                                                                          |     43  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 3| 3| 3| 0| 2| 3| 3| 3| 9| 5| 2| 3| 3| 4| 1| 7| 3| 3| 0| 2| 2| 3| 3|             
                                           | 3| 9| 5| 5| 5| 7| 9| 5| 5| 5| 2| 1| 9| 5| 5| 2| 2| 3| 6| 6| 3| 7| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +        +     +  +              +  +        +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +        +     +  +              +  +        +                  |             
      Hyperplasia, Lymphoid                |    3     1        2     2  3              1  2        1                  |             
      Inflammation                         |                                                                          |             
      Pigmentation                         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                         +                 +                       +      |             
      Hyperplasia, Lymphoid                |                         2                                         1      |             
      Pigmentation                         |                                           1                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | X  X  X  X  X        X  X  X     X  X  X  X     X  X  X  X           X  X|             
      Clear Cell Focus                     |                         X                                                |             
      Hepatodiaphragmatic Nodule           |          X                                      X        X               |             
      Hyperplasia                          |                         2        2                                       |             
      Inflammation, Acute                  |          2                                                               |             
      Inflammation, Granulomatous          |                                           2     1  1  1              1  2|             
      Leukocytosis                         |                                  2                                       |             
      Vacuolization Cytoplasmic            |                3                                                         |             
      Bile Duct, Hyperplasia               |                         1  1           1           1                     |             
      Centrilobular, Necrosis              |                               3                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |          1           3                                      1            |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +                                                         |             
      Hyperplasia                          |                3                                                         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +                                                         |             
      Necrosis                             |                2                                                         |             
                                            __________________________________________________________________________|             
   Tongue                                  |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +                                                  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                          +               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                4         |             
      Hyperplasia                          |                            3                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 3| 3| 3| 0| 2| 3| 3| 3| 9| 5| 2| 3| 3| 4| 1| 7| 3| 3| 0| 2| 2| 3| 3|             
                                           | 3| 9| 5| 5| 5| 7| 9| 5| 5| 5| 2| 1| 9| 5| 5| 2| 2| 3| 6| 6| 3| 7| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  | 2     1  2           4  2                          1        2     3      |             
      Pars Distalis, Ectasia               |             3           2                                   2            |             
      Pars Distalis, Hyperplasia           | 1     1                 2                 2        1        2     1      |             
      Pars Distalis, Hypertrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2     1              4        1     1  2        3  1  1        2  3   |             
      Follicle, Dilatation                 |                                                                          |             
      Follicular Cell, Hyperplasia, Cystic |                                                                         2|             
      Follicular Cell, Hyperplasia         |       2              1                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
      Hyperplasia                          |                      4              4                                    |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    1                                                                     |             
      Duct, Dilatation                     |                         3                                                |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                                                +         |             
      Follicle, Cyst                       |                                                                4         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           4                              |             
      Dilatation                           |       2                                                                  |             
      Hemorrhage                           |                                                             3            |             
      Cervix, Cyst                         |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                   +      |             
      Hypoplasia                           |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                            +         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                  2  3     1                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                2                                                         |             
      Hemorrhage, Focal                    |                                                                          |             
      Infarct                              |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +           +        +     +  +     +  +  +  +  +     +  +  +|             
      Hyperplasia                          | 1                                                        2               |             
      Inflammation, Acute                  |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 3| 3| 3| 0| 2| 3| 3| 3| 9| 5| 2| 3| 3| 4| 1| 7| 3| 3| 0| 2| 2| 3| 3|             
                                           | 3| 9| 5| 5| 5| 7| 9| 5| 5| 5| 2| 1| 9| 5| 5| 2| 2| 3| 6| 6| 3| 7| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Duct, Ectasia                        | 1        1                       2     1        2     2           1      |             
      Duct, Hyperplasia                    |                                           2                              |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +     +           +        +                    +               |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                  +                             +         |             
      Osteopetrosis                        |                                  2                             1         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +                                +                        |             
      Compression                          |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                         +              +     +                 +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +     +                                                |             
      Lens, Cataract                       |                   2     4                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +     +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +|             
      Inflammation, Chronic                |                                           2                              |             
      Nephropathy                          | 2  2  2  2  1  1  3  1  1  2  2  2  2  2  3     3  2  3  2  1        1  3|             
      Renal Tubule, Hyperplasia            |                                           3                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                     +                                    |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                     4                                    |             
      Metaplasia, Squamous                 |                                     3                                    |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 7| 8| 3| 3| 3| 1| 7| 3| 3| 3|             
                                           | 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 6| 3| 6| 6| 6| 6| 4| 3| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +     +  +           +     +  +           +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +     +  +           +        +           +           +      |             
      Hyperplasia, Lymphoid                |             2     2  2           1        2                       2      |             
      Inflammation                         |                                                       3                  |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                        +                          +  +   |             
      Hyperplasia, Lymphoid                |                                        1                          2  1   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | X     X  X  X  X  X  X     X  X  X  X  X     X     X  X  X              X|             
      Clear Cell Focus                     |                                                       X  X               |             
      Hepatodiaphragmatic Nodule           | X                          X                             X  X     X      |             
      Hyperplasia                          |                            1                          1                  |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Granulomatous          | 2              2  2     3                 2  1                 2         |             
      Leukocytosis                         |                                                             2            |             
      Vacuolization Cytoplasmic            |                               2                 3              3         |             
      Bile Duct, Hyperplasia               |       1              1                                                   |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Fat, Necrosis, Focal                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |    1  2                 1              1                          1      |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                 +                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                 +                        |             
      Hyperplasia                          |                                                                          |             
      Ulcer                                |                                                 4                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                 +                        |             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 7| 8| 3| 3| 3| 1| 7| 3| 3| 3|             
                                           | 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 6| 3| 6| 6| 6| 6| 4| 3| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |       2           3        1        2           2        2  1            |             
      Pars Distalis, Ectasia               |                4              3                 2                    2  4|             
      Pars Distalis, Hyperplasia           |                                        1        2                 2      |             
      Pars Distalis, Hypertrophy           |                         3                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    3     1  1  4  1  3  1           1           4  1  1  1  1     1  1   |             
      Follicle, Dilatation                 |             1                                                            |             
      Follicular Cell, Hyperplasia, Cystic |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 3                        |             
      Inflammation, Acute                  |                                                 3                        |             
      Inflammation, Chronic                |          1                                                  1            |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +                          +                             +            |             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             3                                                            |             
      Dilatation                           |                         3  3                                             |             
      Hemorrhage                           |                                                                          |             
      Cervix, Cyst                         |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
      Hypoplasia                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                             3            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                          |             
      Hemorrhage, Focal                    |                               3                                          |             
      Infarct                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +   |             
      Hyperplasia                          |             4                                1                           |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 7| 8| 3| 3| 3| 1| 7| 3| 3| 3|             
                                           | 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 6| 3| 6| 6| 6| 6| 4| 3| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.0%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Duct, Ectasia                        | 2  2  2  3                 3        2     2  2  2     3  2  2     2      |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +                                      +                           |             
      Acanthosis                           |       3                                      2                           |             
      Hyperkeratosis                       |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +                 +                    +                        |             
      Osteopetrosis                        |          3                 2                    2                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                                            +                 +         |             
      Compression                          | 3                                            2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy                          | 3  4  2  3  2  2  1  2  1  2  1     1  2     3  4  3  2  2     3  1  2  2|             
      Renal Tubule, Hyperplasia            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +                                          |             
      Hyperplasia                          |                               4                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  15        |
      Hyperplasia, Lymphoid                |                                                                          |     14  1.9|
      Inflammation                         |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   6        |
      Hyperplasia, Lymphoid                |                                                                          |      5  1.4|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus, Multiple           |                                                                          |     35     |
      Clear Cell Focus                     |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           |                                                                          |      8     |
      Hyperplasia                          |                                                                          |      4  1.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |     13  1.7|
      Leukocytosis                         |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      4  2.8|
      Bile Duct, Hyperplasia               |                                                                          |      6  1.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Necrosis, Focal                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Atrophy, Focal                       |                                                                          |      8  1.4|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |   2        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |   1        |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Cyst                  |                                                                          |     15  2.0|
      Pars Distalis, Ectasia               |                                                                          |      8  2.8|
      Pars Distalis, Hyperplasia           |                                                                          |     10  1.5|
      Pars Distalis, Hypertrophy           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Hyperplasia                  |                                                                          |     26  1.8|
      Follicle, Dilatation                 |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia, Cystic |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  48        |
      Hyperplasia                          |                                                                          |      3  3.7|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      3  1.0|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |   4        |
      Follicle, Cyst                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Cyst                                 |                                                                          |      2  3.5|
      Dilatation                           |                                                                          |      3  2.7|
      Hemorrhage                           |                                                                          |      1  3.0|
      Cervix, Cyst                         |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |   1        |
      Hypoplasia                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Granulocytic                     |                                                                          |      3  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                                          |      1  2.0|
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  38        |
      Hyperplasia                          |                                                                          |      4  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Duct, Ectasia                        |                                                                          |     20  2.0|
      Duct, Hyperplasia                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |   8        |
      Acanthosis                           |                                                                          |      2  2.5|
      Hyperkeratosis                       |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |   5        |
      Osteopetrosis                        |                                                                          |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |   5        |
      Compression                          |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Lens, Cataract                       |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  45        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Nephropathy                          |                                                                          |     44  2.1|
      Renal Tubule, Hyperplasia            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |   2        |
      Hyperplasia                          |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 9| 8| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.0%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|             
                                           | 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Edema                                |                                              2                           |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    1                     |             
      Mineralization                       |                                        2                                 |             
      Parasite Metazoan                    | X     X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Mineralization                       |                                        2                                 |             
      Parasite Metazoan                    |                                                       X        X        X|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   1      |             
      Hyperplasia, Lymphoid                |                               1           3        2  2     2            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   4      |             
      Hyperplasia, Lymphoid                | 2              2                                   2  2                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |       X  X                                X        X  X  X               |             
      Clear Cell Focus                     |                                                       X                  |             
      Cytoplasmic Alteration, Focal        |       2                                                                  |             
      Ectasia                              |             3              2                                             |             
      Eosinophilic Focus                   |                                                                          |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                     X              X  X                  |             
      Hyperplasia, Focal                   |                   2     2                                                |             
      Hypertrophy, Focal                   |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                             2            |             
      Bile Duct, Hyperplasia               |          1                                                               |             
      Centrilobular, Necrosis              |                                                                   2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                          +                              |             
      Autolysis                            |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Fat, Necrosis                        |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|             
                                           | 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |    2  1  1           2           3     2                          1  1   |             
      Autolysis                            |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                  1                                       |             
      Hyperplasia                          |                            1                                             |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   1      |             
      Mineralization                       |                                        3                                 |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                        +                                 |             
      Aorta, Mineralization                |                                        4                                 |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1     3  2  3     1  2     1  1  1     2     1     2  2  1  1  2  1  2  2|             
      Mineralization                       |                                        4                                 |             
      Atrium Left, Thrombosis              |                            3                                             |             
      Valve, Inflammation, Acute           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             1            |             
      Hyperplasia                          |       1           1                       1  1     1     1           2  1|             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |    2  1                          1  1                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1           2  2     1  1                  |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |       1                                                     3            |             
      Pars Distalis, Hemorrhage            |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|             
                                           | 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |    1  2     1                             1           2                  |             
      Pars Distalis, Hypertrophy           | 1                    1           1                       1               |             
      Pars Intermedia, Hyperplasia         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1                 2     3           1     2        1  1  2           1   |             
      Follicle, Dilatation                 |                                                                          |             
      Follicular Cell, Hyperplasia, Cystic |                   1                                                      |             
      Follicular Cell, Hyperplasia         |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +     +              +  +                                             |             
      Inflammation, Chronic Active         |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |    1  1                                3  1        4                     |             
      Inflammation, Chronic                | 1        2        2        2     1  2        1                       1  1|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      1   |             
      Inflammation, Acute                  |    4  1              2  1     1                       1     1            |             
      Inflammation, Chronic                |                                        1  2     1                 3  3   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       2                                                                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                 3                        |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                             +                                          |             
      Anemia                               |                               X                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Autolysis                |                                                                          |             
      Mesenteric, Hemorrhage               |                            2                                             |             
      Mesenteric, Lymphocyte, Depletion    |                                                                          |             
          Cellular                         |                                        3                                 |             
      Pancreatic, Congestion               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|             
                                           | 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Ectasia                  |                      2                                                   |             
      Pancreatic, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Re Cell                 |       1                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           2                              |             
      Fibrosis                             |       2                                      2        1                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2               |             
      Congestion                           |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |       2                                                              2   |             
      Inflammation, Chronic                |             3                                                            |             
      Duct, Ectasia                        |                                                                   1      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic Active         |    2                                                                     |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                      1   |             
      Hydrocephalus                        |                                                                          |             
      Inflammation, Acute, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|             
                                           | 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                   2     2|             
      Mineralization                       |                                        2                                 |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                         3                                2               |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                              2  2                        |             
      Fungus                               |                      X     X              X              X               |             
      Inflammation, Chronic                |                                                                         1|             
      Mucosa, Inflammation, Chronic Active |                      3     2              3  3  2        3               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |       2                                               2                  |             
      Respiratory Epithelium, Hyperplasia  |                                                          3               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Nephropathy                          | 1  2  3  2  3  2  3  2  2  3  2  2     4  3  3  2  3  2  3  1  2  2  3  3|             
      Renal Tubule, Degeneration           |                               3                                          |             
      Renal Tubule, Hyperplasia            |                                        1                                 |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hypertrophy, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|             
                                           | 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                      3   |             
      Edema                                |                                                                          |             
      Inflammation, Acute                  |                   2                                                  4   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                      3   |             
      Hyperplasia, Lymphoid                |                                                             1            |             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |             X                                            X              X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                      3   |             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |       X     X  X                                X                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                      4   |             
      Hyperplasia, Lymphoid                |                         3  2        2           1  2  1                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                      4   |             
      Hyperplasia, Lymphoid                |                2                                                         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |                X                          X     X           X            |             
      Clear Cell Focus                     |                         X                                                |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Ectasia                              |                                                                          |             
      Eosinophilic Focus                   |                                                 X                        |             
      Eosinophilic Focus, Multiple         |                                                             X            |             
      Hepatodiaphragmatic Nodule           |             X     X                       X                              |             
      Hyperplasia, Focal                   |                                                    2                     |             
      Hypertrophy, Focal                   |                                                                         2|             
      Inflammation, Granulomatous          | 2                                                                        |             
      Leukocytosis                         |                      4                                                   |             
      Necrosis                             |                                              4                           |             
      Thrombosis                           |                                                             2            |             
      Bile Duct, Hyperplasia               | 1     2        1        1              1  1     1     1              4   |             
      Centrilobular, Necrosis              |                   3                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +  +                 +  +  +              +     +  +   |             
      Autolysis                            |                   4                                                      |             
      Inflammation, Acute                  |                                                                      3   |             
      Fat, Necrosis                        |                                        2  3                 2     3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|             
                                           | 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |          2  2     2           1  2  1  1  1        2  1     2  2  1  1  2|             
      Autolysis                            |                   3                                                  3   |             
      Artery, Inflammation, Chronic        |                   3                                                     2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              |                         1                 1                              |             
      Inflammation, Chronic                |                            2                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                                                    2                     |             
      Ulcer                                | 4                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Mineralization                       |                                                    2     2               |             
      Ulcer                                |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1  1  3  2  1  2  3     1  3  2  1  2  2  1  2  2  1  2  2  1  2  2  1  1|             
      Mineralization                       |                                        1                                 |             
      Atrium Left, Thrombosis              |                                                                          |             
      Valve, Inflammation, Acute           |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 1        1                 1                             1               |             
      Hypertrophy                          | 2                       2     1                       1                  |             
      Vacuolization Cytoplasmic            | 1                                                        1     2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                                                     |             
      Bilateral, Hyperplasia               |                                           3                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    1                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |       2     1              1                                   1        2|             
      Pars Distalis, Hemorrhage            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|             
                                           | 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |       2  1  1  3  1  1                          2        2  2            |             
      Pars Distalis, Hypertrophy           |                            2  1     1                          2     1   |             
      Pars Intermedia, Hyperplasia         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2     3  3        2           1                    3  1     1         |             
      Follicle, Dilatation                 |                         1           2                                    |             
      Follicular Cell, Hyperplasia, Cystic |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |    3                                                                     |             
      Inflammation, Chronic                |                                           1                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |    1                 2                 1  1                              |             
      Inflammation, Chronic                |          1                 1                       1  1                 1|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                      3   |             
      Inflammation, Chronic                | 2           1     2  1  1  1  3  3  1  2        1  2  1  1        2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3                                                                     |             
      Hemorrhage                           |                                                                          |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                +              +     +                                    |             
      Anemia                               |                X                                                         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                              4                       3   |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Mesenteric, Autolysis                |                                                                      3   |             
      Mesenteric, Hemorrhage               |                                                                          |             
      Mesenteric, Lymphocyte, Depletion    |                                                                          |             
          Cellular                         |                                                                          |             
      Pancreatic, Congestion               |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|             
                                           | 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Ectasia                  |                                     3                                    |             
      Pancreatic, Hyperplasia              |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Ectasia                              |                                                          2               |             
      Hemorrhage                           |                                                 2                        |             
      Hyperplasia                          |                               1                                          |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   2        3                                            2|             
      Fibrosis                             |                               3                                          |             
      Hematopoietic Cell Proliferation     |                      3                                                   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                      2   |             
      Necrosis                             |                                     4                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          | 3                                                                        |             
      Hyperplasia                          |                      1                 1                                 |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Ectasia                        |                            1     2                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                                                                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                  2                                       |             
      Hydrocephalus                        | 1                                                                        |             
      Inflammation, Acute, Multifocal      |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      3   |             
      Hemorrhage                           |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|             
                                           | 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                              3                           |             
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    3  1                                                        2         |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                    2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                  2  2  2                                 |             
      Fungus                               |                                                                          |             
      Inflammation, Chronic                |       1  2           1                                                   |             
      Mucosa, Inflammation, Chronic Active |                                  3  3  4                                 |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |             2                                         3  3               |             
      Respiratory Epithelium, Hyperplasia  |                                     2  3                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Lens, Cataract                       |                      4                                                   |             
      Retina, Degeneration                 |                      4                                                   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Multifocal      |                   3                                                      |             
      Nephropathy                          | 2  1  3  3  3  2  2  2  3  3  2  3  3  3  3  2  3  4  4  3  3  2  2  4  3|             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                          1  3            |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hypertrophy, Focal               |                                                          3               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |     11  1.9|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus, Multiple           |                                                                          |     10     |
      Clear Cell Focus                     |                                                                          |      2     |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |      2  2.5|
      Eosinophilic Focus                   |                                                                          |      1     |
      Eosinophilic Focus, Multiple         |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                                                          |      6     |
      Hyperplasia, Focal                   |                                                                          |      3  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Leukocytosis                         |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               |                                                                          |     10  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Centrilobular, Necrosis              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  11        |
      Autolysis                            |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Atrophy, Focal                       |                                                                          |     23  1.6|
      Autolysis                            |                                                                          |      2  3.0|
      Artery, Inflammation, Chronic        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  49        |
      Atrophy                              |                                                                          |      2  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      3  2.3|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |     43  1.7|
      Mineralization                       |                                                                          |      2  2.5|
      Atrium Left, Thrombosis              |                                                                          |      1  3.0|
      Valve, Inflammation, Acute           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  48        |
      Cyst                                 |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |     12  1.1|
      Hypertrophy                          |                                                                          |      4  1.5|
      Vacuolization Cytoplasmic            |                                                                          |      7  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  48        |
      Hyperplasia                          |                                                                          |      6  1.3|
      Bilateral, Hyperplasia               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Cyst                  |                                                                          |      7  1.6|
      Pars Distalis, Hemorrhage            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |     14  1.6|
      Pars Distalis, Hypertrophy           |                                                                          |      9  1.2|
      Pars Intermedia, Hyperplasia         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Hyperplasia                  |                                                                          |     17  1.8|
      Follicle, Dilatation                 |                                                                          |      2  1.5|
      Follicular Cell, Hyperplasia, Cystic |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   4        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  49        |
      Inflammation, Acute                  |                                                                          |      9  1.7|
      Inflammation, Chronic                |                                                                          |     14  1.3|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      8  1.8|
      Inflammation, Chronic                |                                                                          |     20  1.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  50        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   5        |
      Anemia                               |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  3.5|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
      Mesenteric, Autolysis                |                                                                          |      1  3.0|
      Mesenteric, Hemorrhage               |                                                                          |      1  2.0|
      Mesenteric, Lymphocyte, Depletion    |                                                                          |            |
          Cellular                         |                                                                          |      1  3.0|
      Pancreatic, Congestion               |                                                                          |      1  2.0|
      Pancreatic, Ectasia                  |                                                                          |      2  2.5|
      Pancreatic, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  49        |
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Hyperplasia, Re Cell                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Congestion                           |                                                                          |      4  2.3|
      Fibrosis                             |                                                                          |      4  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  49        |
      Galactocele                          |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      4  1.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Duct, Ectasia                        |                                                                          |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Compression                          |                                                                          |      2  1.5|
      Hydrocephalus                        |                                                                          |      1  1.0|
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      5  2.2|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Foreign Body                         |                                                                          |      5  2.0|
      Fungus                               |                                                                          |      4     |
      Inflammation, Chronic                |                                                                          |      4  1.3|
      Mucosa, Inflammation, Chronic Active |                                                                          |      9  2.9|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      5  2.4|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Inflammation, Acute, Multifocal      |                                                                          |      1  3.0|
      Nephropathy                          |                                                                          |     49  2.6|
      Renal Tubule, Degeneration           |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      3  1.7|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Hypertrophy, Focal               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                               2                             4            |             
      Diverticulum                         |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                             4            |             
      Hyperplasia, Lymphoid                |                                                    1           1         |             
      Hyperplasia, Adenomatous             |                                                                          |             
      Parasite Metazoan                    |    X  X                             X              X              X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                             4            |             
      Parasite Metazoan                    |    X                                   X              X           X  X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                             4            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                             4            |             
      Hyperplasia, Lymphoid                |       3  3     3  1     1                 3  2  2  2  2                  |             
      Pigmentation                         |                1        1                 1                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                               4                             4            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                   1                       1                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                             3            |             
      Basophilic Focus, Multiple           |                                     X     X                              |             
      Clear Cell Focus                     |                      X                                X                  |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                         2|             
      Ectasia                              |          2                                                               |             
      Eosinophilic Focus                   |                                                                X         |             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X              X        X                              |             
      Hyperplasia, Focal                   |                            2        1                                    |             
      Hypertrophy, Focal                   | 1              2        1                                                |             
      Hypertrophy, Multifocal              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Granulomatous          |                                     1                 1                  |             
      Vacuolization Cytoplasmic            |                                                       1                  |             
      Bile Duct, Hyperplasia               |       1                                               1           1      |             
      Centrilobular, Necrosis              |                                                 3                        |             
      Centrilobular, Vacuolization         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Cytoplasmic                      |                2                                         2               |             
      Hepatocyte, Degeneration, Cystic     |    2        1              1                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +                       +                                   +  +|             
      Inflammation, Chronic                |       3                                                                  |             
      Artery, Inflammation, Chronic        |          2                                                               |             
      Fat, Necrosis                        | 2                                                                    2  2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Atrophy, Focal                       | 2           2  1     1  1  1           2     1     1     1     1        1|             
      Autolysis                            |                                                                          |             
      Cytoplasmic Alteration               |                                     1                                    |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                      2   |             
      Acinar Cell, Cytoplasmic Alteration  |                                                                      1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                 2                    1   |             
      Mucosa, Cyst                         |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  2  2  1  1  1  1  2  2  2  1  1  2  2  2  3  2  2  2  2  1  3  2  1  1|             
      Atrium Left, Thrombosis              | 3              4                       2                       4        3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hyperplasia                          |             1                       1  1     1           1     2  1     1|             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                 2  2  1                 1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                          2                    1  1     1               |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |    1                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                                      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                      2           1                    1                  |             
      Pars Distalis, Hemorrhage            |                                                    2                     |             
      Pars Distalis, Hyperplasia           |             1  1                       1     1                           |             
      Pars Distalis, Hypertrophy           |                                                                   1      |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                              X                           |             
      C-Cell, Hyperplasia                  |       1  2  4              1     1     3                 1        1      |             
      Follicle, Dilatation                 |                                                                          |             
      Follicular Cell, Hyperplasia, Cystic |                                                                          |             
      Follicular Cell, Hypertrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |             1  1  3  1  1                    1  1     1                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                                        2                                 |             
      Inflammation, Acute                  | 3     1                                                        1         |             
      Inflammation, Chronic                |             1     2              2     1  2        1     2           3   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Dilatation                           |                               2                          2               |             
      Epithelium, Degeneration             |             2                                                            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                             4            |             
      Hemorrhage                           |                                                                          |             
      Hypoplasia                           |                2                                3                        |             
      Myelofibrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Re Cell       |                                                                          |             
      Mediastinal, Hemorrhage              |       1                                                                  |             
      Mediastinal, Hyperplasia, Re Cell    |       2                                                                  |             
      Mesenteric, Congestion               |                                                                          |             
      Mesenteric, Hyperplasia, Re Cell     |       2                                                                  |             
      Mesenteric, Pigmentation             |                         2                 3                       2  2   |             
      Pancreatic, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          3               |             
      Ectasia                              |                                                                   3      |             
      Hemorrhage                           |                                                             3            |             
      Hyperplasia                          |          1                                      2        2           2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                                                  |             
      Autolysis                            |                                                             3            |             
      Congestion                           |                                     2                                    |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Pigmentation                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  I  +  +  I  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  I  +  I  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                   2                                2     3           1  2|             
      Duct, Ectasia                        |                                                 2        2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |    4                                                                     |             
      Inflammation, Chronic Active         | 3                                                                        |             
      Face, Inflammation, Chronic          |                                                          3               |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
      Tail, Cyst Epithelial Inclusion      |                                                                          |             
      Tail, Hyperkeratosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |             1                                                            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   2                                      2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Choroid Plexus, Infiltration         |                                                                          |             
          Cellular, Lymphocyte             |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                             2            |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |             1     1  1     1                                             |             
      Inflammation, Chronic                |                1                          2                              |             
      Inflammation, Granulomatous          |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                1         |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                     2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                               2                                          |             
      Foreign Body                         |          2              2                    2                           |             
      Fungus                               |                                                                   X      |             
      Inflammation, Chronic                |       1     1  1                                                         |             
      Mucosa, Inflammation, Chronic Active | 1        2              4                    1                    4      |             
      Mucosa, Glands, Exudate              |                      2                                                   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                     2  1              2  1     1         |             
      Respiratory Epithelium, Hyperplasia  |                         2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Bilateral, Lens, Cataract            |                            4                                             |             
      Bilateral, Retina, Degeneration      |                            3                                             |             
      Cornea, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                             3            |             
      Congestion                           |                                                                          |             
      Mineralization                       |                                                                      1   |             
      Nephropathy                          | 2  3  3  4  4  3  4  3  3  3  2  1  3  3  3  3  3  3  3  4     3  3  3  4|             
      Cortex, Cyst                         |             2                                                            |             
      Renal Tubule, Hyperplasia            |          3  1        3                 2                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|             
                                           | 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   3                                         2            |             
      Diverticulum                         |                                                 3                        |             
      Parasite Metazoan                    |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   3                                         2            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Adenomatous             |                                                 2                        |             
      Parasite Metazoan                    |                      X     X     X     X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   3                                         2            |             
      Parasite Metazoan                    | X              X                                         X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   3                                         2            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   4                                         2            |             
      Hyperplasia, Lymphoid                |          1                    1        2              2        2         |             
      Pigmentation                         |                                                 1                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   4                                         2            |             
      Hyperplasia, Lymphoid                |          2                    2           2                              |             
      Pigmentation                         |                               2                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Basophilic Focus, Multiple           |          X  X  X     X                                               X   |             
      Clear Cell Focus                     |                      X     X           X                                 |             
      Congestion                           |                   3                                                      |             
      Cyst                                 |                                                                          |             
      Ectasia                              |                                                                          |             
      Eosinophilic Focus                   |    X                    X  X                                             |             
      Eosinophilic Focus, Multiple         |                                                          X               |             
      Hepatodiaphragmatic Nodule           |                   X                    X                    X            |             
      Hyperplasia, Focal                   |          2  1  3                                                         |             
      Hypertrophy, Focal                   |          2                                                               |             
      Hypertrophy, Multifocal              |       2                                                                  |             
      Inflammation, Acute                  |                                              1                           |             
      Inflammation, Granulomatous          |                                  1                    1                  |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               | 1     1        1        1  1        1  1        1     1  2  1  1  1  1   |             
      Centrilobular, Necrosis              |                   3                                                      |             
      Centrilobular, Vacuolization         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|             
                                           | 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Cytoplasmic                      |                                                                          |             
      Hepatocyte, Degeneration, Cystic     |       1        2                    1     2     1        2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +              +  +                                         +      |             
      Inflammation, Chronic                |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Fat, Necrosis                        |       1              2  2                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                         4|             
      Atrophy, Focal                       | 1           1  1           1     2        2     1  2           2         |             
      Autolysis                            |                   4                                                      |             
      Cytoplasmic Alteration               |                                                                          |             
      Hyperplasia                          |          2                                                               |             
      Inflammation, Chronic                |                                                                   2      |             
      Artery, Inflammation, Chronic        |          3              4              2                                 |             
      Duct, Cyst                           |       2                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  1                                       |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1     2                             3            |             
      Inflammation, Acute                  |                               2                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      1                                         2  1      |             
      Mucosa, Cyst                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  2  3  2  2  2  3  1  2  2  2  2  1  2  1  2  2  1  1  3  1  1  2  1  1|             
      Atrium Left, Thrombosis              |       2     3     3                             4     3                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             X                                                            |             
      Hyperplasia                          |    1                    2  1                 1     1  1  2     1     2  1|             
      Hypertrophy                          |                      2                                                   |             
      Vacuolization Cytoplasmic            |          1                    2  1                                1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1           3  1     2  1  1     1                 1        1     2   |             
      Bilateral, Hyperplasia               |                                           2  2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|             
                                           | 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                   3        3                                             |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |    2        1                    2                                2      |             
      Pars Distalis, Hypertrophy           | 1                                         1  1              1            |             
      Pars Nervosa, Cyst                   |                                                          2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |    3                             1  2                    1           1   |             
      Follicle, Dilatation                 |                      1              2  1                                2|             
      Follicular Cell, Hyperplasia, Cystic |             1                                                            |             
      Follicular Cell, Hypertrophy         |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                    2                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    3                     |             
      Inflammation, Acute                  |                         1                          3     2               |             
      Inflammation, Chronic                |    1  3  3                          2     2  1                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                         1                                                |             
      Inflammation, Chronic                |       1  4  1              1  3  2     2  2  1  1  1  1  1        1  2   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Epithelium, Degeneration             |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                               2                                          |             
      Interstitial Cell, Hyperplasia       |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hemorrhage                           |                                              2                           |             
      Hypoplasia                           |                                                 3                        |             
      Myelofibrosis                        |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|             
                                           | 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Re Cell       |       2                                                                  |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Re Cell    |                                                                          |             
      Mesenteric, Congestion               |       1                                         2                        |             
      Mesenteric, Hyperplasia, Re Cell     |                                                                          |             
      Mesenteric, Pigmentation             |    1     2  2  1              1           1                              |             
      Pancreatic, Hyperplasia              |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Fibrosis                             |          2                                                               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                  2                                       |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
      Duct, Ectasia                        |                         1                                      2     3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Face, Inflammation, Chronic          |                                                                          |             
      Subcutaneous Tissue, Abscess         |             3                                                            |             
      Tail, Cyst Epithelial Inclusion      |          X                 X                                             |             
      Tail, Hyperkeratosis                 |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |          1                                                     X         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          2                    2                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|             
                                           | 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Choroid Plexus, Infiltration         |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                             2            |             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                1                                                         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Foreign Body                         |                                     2        2                           |             
      Fungus                               |             X                                                            |             
      Inflammation, Chronic                |                                           1                              |             
      Mucosa, Inflammation, Chronic Active |       2     2                       2        2                           |             
      Mucosa, Glands, Exudate              |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |    2     2                             2                       1  2     2|             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Bilateral, Lens, Cataract            |                                                                          |             
      Bilateral, Retina, Degeneration      |                                                                          |             
      Cornea, Inflammation, Chronic        |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                   3                                                      |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  3  1  4  3  3  2  3  3  3  4  2  3  3  3  2  3  3  3  3  2  4  3  4  3|             
      Cortex, Cyst                         |                                                 2                        |             
      Renal Tubule, Hyperplasia            |                      2        2        2                       3         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 6| 7| 6| 7| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      4  2.8|
      Diverticulum                         |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      3  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  1.0|
      Hyperplasia, Adenomatous             |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      9     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
      Autolysis                            |                                                                          |      3  3.0|
      Parasite Metazoan                    |                                                                          |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
      Autolysis                            |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      3  3.3|
      Hyperplasia, Lymphoid                |                                                                          |     15  2.0|
      Pigmentation                         |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
      Autolysis                            |                                                                          |      4  3.5|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Pigmentation                         |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Basophilic Focus, Multiple           |                                                                          |      7     |
      Clear Cell Focus                     |                                                                          |      5     |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      4     |
      Eosinophilic Focus, Multiple         |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                                                          |      6     |
      Hyperplasia, Focal                   |                                                                          |      5  1.8|
      Hypertrophy, Focal                   |                                                                          |      4  1.5|
      Hypertrophy, Multifocal              |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 6| 7| 6| 7| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Granulomatous          |                                                                          |      4  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                                                                          |     17  1.1|
      Centrilobular, Necrosis              |                                                                          |      2  3.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      2  2.0|
      Hepatocyte, Degeneration, Cystic     |                                                                          |      9  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  11        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      6  1.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  49        |
      Atrophy, Diffuse                     |                                                                          |      1  4.0|
      Atrophy, Focal                       |                                                                          |     21  1.3|
      Autolysis                            |                                                                          |      1  4.0|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      3  3.0|
      Duct, Cyst                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Atrophy                              |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Acinar Cell, Cytoplasmic Alteration  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      3  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Mineralization                       |                                                                          |      5  1.4|
      Mucosa, Cyst                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |     50  1.7|
      Atrium Left, Thrombosis              |                                                                          |     10  3.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 6| 7| 6| 7| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Hyperplasia                          |                                                                          |     18  1.2|
      Hypertrophy                          |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      8  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia                          |                                                                          |     15  1.4|
      Bilateral, Hyperplasia               |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
      Autolysis                            |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  49        |
      Pars Distalis, Cyst                  |                                                                          |      5  2.0|
      Pars Distalis, Hemorrhage            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      8  1.4|
      Pars Distalis, Hypertrophy           |                                                                          |      5  1.0|
      Pars Nervosa, Cyst                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |                                                                          |     13  1.7|
      Follicle, Dilatation                 |                                                                          |      4  1.5|
      Follicular Cell, Hyperplasia, Cystic |                                                                          |      1  1.0|
      Follicular Cell, Hypertrophy         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  48        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      3  2.0|
      Inflammation, Chronic                |                                                                          |     14  1.6|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  49        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      4  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 6| 7| 6| 7| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |     23  1.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  49        |
      Dilatation                           |                                                                          |      2  2.0|
      Epithelium, Degeneration             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  49        |
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hypoplasia                           |                                                                          |      3  2.7|
      Myelofibrosis                        |                                                                          |      1  1.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  48        |
      Axillary, Hyperplasia, Re Cell       |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  1.0|
      Mediastinal, Hyperplasia, Re Cell    |                                                                          |      1  2.0|
      Mesenteric, Congestion               |                                                                          |      2  1.5|
      Mesenteric, Hyperplasia, Re Cell     |                                                                          |      1  2.0|
      Mesenteric, Pigmentation             |                                                                          |     10  1.7|
      Pancreatic, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  48        |
      Congestion                           |                                                                          |      1  3.0|
      Ectasia                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Autolysis                            |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 6| 7| 6| 7| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  43        |
      Hyperplasia                          |                                                                          |      6  2.0|
      Duct, Ectasia                        |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Face, Inflammation, Chronic          |                                                                          |      1  3.0|
      Subcutaneous Tissue, Abscess         |                                                                          |      1  3.0|
      Tail, Cyst Epithelial Inclusion      |                                                                          |      2     |
      Tail, Hyperkeratosis                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Fibrous Osteodystrophy               |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Compression                          |                                                                          |      5  2.0|
      Choroid Plexus, Infiltration         |                                                                          |            |
          Cellular, Lymphocyte             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      5  1.2|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  49        |
      Autolysis                            |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      5  2.0|
      Fungus                               |                                                                          |      2     |
      Inflammation, Chronic                |                                                                          |      4  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 6| 6| 6| 7| 6| 7| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Inflammation, Chronic Active |                                                                          |      9  2.2|
      Mucosa, Glands, Exudate              |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |     11  1.6|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Bilateral, Lens, Cataract            |                                                                          |      1  4.0|
      Bilateral, Retina, Degeneration      |                                                                          |      1  3.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy                          |                                                                          |     49  2.9|
      Cortex, Cyst                         |                                                                          |      2  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      8  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  49        |
      Mineralization                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 9| 3| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 3| 3|             
                                           | 9| 8| 1| 2| 2| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 0| 2| 2| 1| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     +  +  +           +  +                       +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +     +  +  +              +                       +  +            |             
      Hyperplasia, Lymphoid                | 1           3  2  3              3                       2  3            |             
      Inflammation                         |                                                                          |             
      Pigmentation                         |       2     1                    1                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +                                   +      |             
      Hyperplasia, Lymphoid                |                               4                                   2      |             
      Intussusception                      |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |    X                 X     X     X  X  X                                X|             
      Clear Cell Focus                     |          X                                                               |             
      Eosinophilic Focus                   |                                     X                                    |             
      Hepatodiaphragmatic Nodule           | X                       X  X        X                                    |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               | 1     1  2        2  2     1     1     1  1  1     1           1  1  1   |             
      Centrilobular, Necrosis              |                1                                                         |             
      Hepatocyte, Degeneration, Cystic     |          2                                                              1|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +                             +        +              +  +   |             
      Necrosis, Focal                      |                                                                   2  3   |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                      +   |             
      Artery, Hypertrophy                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                         +                                            +   |             
      Atrium Left, Thrombosis              |                         2                                            4   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                   +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                   +     +|             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +     +                          +                           |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Pigmentation          |                                              2                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             1     1     1     1  1     2  1  1        1                  |             
      Follicle, Cyst                       |          2                                                               |             
      Follicle, Dilatation                 |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 9| 3| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 3| 3|             
                                           | 9| 8| 1| 2| 2| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 0| 2| 2| 1| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +  +           +                    +                           |             
                                            __________________________________________________________________________|             
   Prostate                                |                                                             +            |             
      Inflammation, Acute                  |                                                             3            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                                               1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                              +              +            |             
      Inguinal, Hyperplasia, Re Cell       |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mesenteric, Ectasia                  |                                                                          |             
      Mesenteric, Hemorrhage               |                                                             2            |             
      Mesenteric, Pigmentation             |                                              1                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |       2        4                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  I  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 1                 2     1                    1                 1  1      |             
      Duct, Ectasia                        |                   2                                      2  2            |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +              +                 +        +              +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Tail, Hyperkeratosis                 |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                 +                                +                     |             
      Compression                          |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +              +                                                  +      |             
      Congestion                           | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 1| 9| 3| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 3| 3|             
                                           | 9| 8| 1| 2| 2| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 0| 2| 2| 1| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Nephropathy                          | 2  3  3  3  2  2  3  3  3  3  3  3  2  3  3  3  2  3  3  4  3  3  4  3  3|             
      Cortex, Cyst                         |                         2                                                |             
      Renal Tubule, Hyperplasia            |                                                       2           4      |             
      Renal Tubule, Hypertrophy, Focal     |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 6| 2| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 7| 6| 7| 2| 2| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 3| 5| 5| 5| 5| 3| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +           +     +  +  +  +  +  +  +                    +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +     +  +  +  +     +                       +           +   |             
      Hyperplasia, Lymphoid                |             3     3  3  3  4     3                       3           3   |             
      Inflammation                         |                            3                                             |             
      Pigmentation                         | 1                 1              2                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +     +                       +            |             
      Hyperplasia, Lymphoid                |                                     3                                    |             
      Intussusception                      |                                                             X            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |                            X                    X        X               |             
      Clear Cell Focus                     |                                     X                                    |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X        X  X     X                 X     X                           |             
      Hyperplasia, Focal                   |                                                          2               |             
      Inflammation, Granulomatous          |                2                                                         |             
      Vacuolization Cytoplasmic            |                            1              1  1                           |             
      Bile Duct, Hyperplasia               |    2        1        1              1  1  1     1                    1   |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Degeneration, Cystic     |                         1                                2  1     1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Necrosis, Focal                      |                            2                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +                                                                     |             
      Artery, Hypertrophy                  |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +                       +           +                           |             
      Atrium Left, Thrombosis              |          2                       2           2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +                                            +                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +                                            +                     |             
      Thrombosis                           |                                                    4                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                             +            |             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +     +                 +                       +  +     +      |             
      Pars Distalis, Cyst                  |                                                             2            |             
      Pars Distalis, Pigmentation          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             2           2  2        1     1     3  1  1              2  2|             
      Follicle, Cyst                       | 2                                                                        |             
      Follicle, Dilatation                 |                                        3  2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 6| 2| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 7| 6| 7| 2| 2| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 3| 5| 5| 5| 5| 3| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +                    +  +                           |             
                                            __________________________________________________________________________|             
   Prostate                                |                                                             +            |             
      Inflammation, Acute                  |                                                             3            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +                       +        +  +              +            |             
      Inguinal, Hyperplasia, Re Cell       |                                              2                           |             
      Mediastinal, Hemorrhage              |                                              2                           |             
      Mesenteric, Ectasia                  |          4                                                               |             
      Mesenteric, Hemorrhage               |                                                                          |             
      Mesenteric, Pigmentation             |                                  2        1                 1            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +                          +                                       |             
      Ectasia                              |                                  4                                       |             
      Hyperplasia                          | 1                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  2                                       |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  I  +  +  +  +  +  +  +  I  +  I  +  +  +  +  +  +  I  +  +  +|             
      Hemorrhage                           |                   2                                                      |             
      Hyperplasia                          |          2                    1                          1               |             
      Duct, Ectasia                        |          2     2                 1                          3            |             
                                            __________________________________________________________________________|             
   Skin                                    |                   +  +              +           +     +  +              +|             
      Acanthosis                           |                                                 4                        |             
      Cyst Epithelial Inclusion            |                                     X                                    |             
      Hyperkeratosis                       |                                                 3                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                       3                  |             
      Tail, Hyperkeratosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                      +   |             
      Compression                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                                          |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 6| 2| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 7| 6| 7| 2| 2| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 3| 5| 5| 5| 5| 3| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +                                                                        |             
      Hyperkeratosis                       | 4                                                                        |             
      Inflammation, Chronic Active         | 3                                                                        |             
      Metaplasia, Squamous                 | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     2                          2         |             
      Nephropathy                          | 2  3  2  4  2  3  2  2  4  4  2  3  3  2  3  2  3  2     3  4  2  3  3  3|             
      Cortex, Cyst                         |                                                                         2|             
      Renal Tubule, Hyperplasia            |                         1        3  3                                    |             
      Renal Tubule, Hypertrophy, Focal     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 6| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  17        |
      Hyperplasia, Lymphoid                |                                                                          |     15  2.8|
      Inflammation                         |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      6  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   5        |
      Hyperplasia, Lymphoid                |                                                                          |      3  3.0|
      Intussusception                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus, Multiple           |                                                                          |     10     |
      Clear Cell Focus                     |                                                                          |      2     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                                                          |     10     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      3  1.0|
      Bile Duct, Hyperplasia               |                                                                          |     22  1.2|
      Centrilobular, Necrosis              |                                                                          |      1  1.0|
      Hepatocyte, Degeneration, Cystic     |                                                                          |      6  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Necrosis, Focal                      |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |   2        |
      Artery, Hypertrophy                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |   5        |
      Atrium Left, Thrombosis              |                                                                          |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |   5        |
      Thrombosis                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |   9        |
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Distalis, Pigmentation          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 6| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |                                                                          |     19  1.4|
      Follicle, Cyst                       |                                                                          |      2  2.0|
      Follicle, Dilatation                 |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   8        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |   2        |
      Inflammation, Acute                  |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  44        |
      Atrophy                              |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   9        |
      Inguinal, Hyperplasia, Re Cell       |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mesenteric, Ectasia                  |                                                                          |      1  4.0|
      Mesenteric, Hemorrhage               |                                                                          |      1  2.0|
      Mesenteric, Pigmentation             |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |   3        |
      Ectasia                              |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  48        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  44        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      9  1.2|
      Duct, Ectasia                        |                                                                          |      7  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  13        |
      Acanthosis                           |                                                                          |      1  4.0|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 6| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
      Tail, Hyperkeratosis                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |   4        |
      Compression                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |   3        |
      Congestion                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |   1        |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Metaplasia, Squamous                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Congestion                           |                                                                          |      2  2.0|
      Nephropathy                          |                                                                          |     49  2.8|
      Cortex, Cyst                         |                                                                          |      2  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      5  2.6|
      Renal Tubule, Hypertrophy, Focal     |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|             
                                           | 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                  +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                  +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                  +                                       |             
      Autolysis                            |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                  +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                  +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +                 +           +        +  +                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                  +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +                 +           +        +  +                           |             
      Autolysis                            |                                  3                                       |             
      Hyperplasia, Lymphoid                | 2  2                 2                    2  2                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                  +                                       |             
      Autolysis                            |                                  3                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                  2                                       |             
      Basophilic Focus, Multiple           |                         X                                                |             
      Clear Cell Focus                     |                                                                      X   |             
      Hepatodiaphragmatic Nodule           |          X                    X     X                                    |             
      Hyperplasia, Focal                   |          2                                                               |             
      Hypertrophy, Focal                   |                                                                2         |             
      Infarct                              |                                                                          |             
      Leukocytosis                         |          2  2  2                                            2        2   |             
      Vacuolization Cytoplasmic            |                   3     1     2                          1               |             
      Bile Duct, Hyperplasia               |          1           2  1     1        1  1              1               |             
      Hepatocyte, Degeneration, Cystic     |                                              2        1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +                    +                                         +   |             
      Hemorrhage                           |                                                                      3   |             
      Inflammation, Chronic                |                            3                                         3   |             
      Necrosis, Focal                      |       2                                                                  |             
      Fat, Necrosis                        |    2                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                  A                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                  +                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                  +                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                  +                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                  +  +                                    |             
      Inflammation, Chronic                |                                  2                                       |             
      Atrium Left, Thrombosis              |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +                             +                    +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|             
                                           | 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                  2                                       |             
      Vacuolization Cytoplasmic            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +                             +                    +                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                  A                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                  +                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +        +        +  +  +  +  +                       +        +|             
      Pars Distalis, Ectasia               |                                                                          |             
      Pars Distalis, Hemorrhage            |                            4                                             |             
      Pars Distalis, Hyperplasia           |                            2           3                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3           2                             4  1  3  1     2     3        1|             
      Follicle, Cyst                       |                                     2                                    |             
      Follicle, Dilatation                 |                                                                          |             
      Follicular Cell, Hyperplasia, Cystic |                                                             2        1   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                  +                          +            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +           +  +              +                     |             
      Cyst                                 |                                                    3                     |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                     2                                    |             
      Inflammation, Chronic Active         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Prostate                                |                               +  +                                       |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                               3                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                  +                                       |             
      Myeloid Cell, Hyperplasia            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +                 +        +            |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Pancreatic, Hyperplasia, Re Cell     |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                  +                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|             
                                           | 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                      2   |             
      Fibrosis                             |             2                             2                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                             3            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                2                                                         |             
      Infarct                              |                                                    3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +|             
      Cyst                                 |                                                                   4      |             
      Galactocele                          |             3                                                            |             
      Hyperplasia                          |    1     2                                                           1   |             
      Inflammation, Chronic                |             3                                                            |             
      Duct, Ectasia                        |                   2        1  3     1           1  2           2        2|             
                                            __________________________________________________________________________|             
   Skin                                    | +        +     +        +        +     +  +                 +  +     +   |             
      Acanthosis                           |          3                                                               |             
      Subcutaneous Tissue, Cyst            |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                           1                              |             
      Tail, Acanthosis                     |                         3              3                       2         |             
      Tail, Hyperkeratosis                 |                         3              3                       3         |             
      Tail, Inflammation, Acute            |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +                                       |             
      Compression                          |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                  +           +                           |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                  +                                       |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|             
                                           | 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                  2                                       |             
      Congestion                           |                                                                          |             
      Nephropathy                          | 2  3  3  3     1  4  3  3  2  2  2  3  3  3  2  3  3  3  3  3  4  4  4  2|             
      Renal Tubule, Hyperplasia            |    1              3                       2                       2  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|             
                                           | 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                   +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                   +      |             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    3                                                                     |             
      Basophilic Focus, Multiple           |                      X                                                   |             
      Clear Cell Focus                     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X     X                                   X            |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                   2                                                      |             
      Infarct                              |                                                                   1      |             
      Leukocytosis                         |                               2                 2                        |             
      Vacuolization Cytoplasmic            |                               2                                          |             
      Bile Duct, Hyperplasia               |             1  1  1  2                                1        2     1   |             
      Hepatocyte, Degeneration, Cystic     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                          +               |             
      Inflammation, Chronic                |                                                                          |             
      Atrium Left, Thrombosis              |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +                                                     +        +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|             
                                           | 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                          +        +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +           +  +        +     +        +                    +|             
      Pars Distalis, Ectasia               |                         4                                                |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3        2     1     2  1              2  1     1     1                 1|             
      Follicle, Cyst                       |                                              2                           |             
      Follicle, Dilatation                 |          3                                                               |             
      Follicular Cell, Hyperplasia, Cystic |       2                          1                                3      |             
      Follicular Cell, Hyperplasia         |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                             +              +     +        +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                                                         3|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                                                             +            |             
      Inflammation, Acute                  |                                                             3            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                           +                 +            |             
      Dilatation                           |                                           2                              |             
      Inflammation, Acute                  |                                                             3            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Interstitial Cell, Hyperplasia       |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                       +                  |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                   +           +           +            |             
      Mediastinal, Hemorrhage              |                                                 2                        |             
      Pancreatic, Hyperplasia, Re Cell     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                     +                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|             
                                           | 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Fibrosis                             |                3                                                         |             
      Hematopoietic Cell Proliferation     |                               2                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                 4                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                          |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  I|             
      Cyst                                 |                                                                          |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                                        2  2              1     1         |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Ectasia                        |       2                    2  1                    2                     |             
                                            __________________________________________________________________________|             
   Skin                                    |                +           +     +                                      +|             
      Acanthosis                           |                                                                          |             
      Subcutaneous Tissue, Cyst            |                3                                                         |             
      Subcutaneous Tissue, Fibrosis        |                3                                                         |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Tail, Acanthosis                     |                            3                                             |             
      Tail, Hyperkeratosis                 |                            2                                             |             
      Tail, Inflammation, Acute            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                              +                           |             
      Compression                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                             +              +        +                  |             
      Hemorrhage                           |                                              2                           |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|             
                                           | 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.0%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Lens, Cataract                       |                                                    4                     |             
      Retina, Inflammation, Chronic        |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |       2                                                                  |             
      Nephropathy                          | 2  2  2  2  3  3  3  3  3  3  2  3  3  3  3     3  3  3  3  2  3  2  3  4|             
      Renal Tubule, Hyperplasia            |                                                                         2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |   1        |
      Autolysis                            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |   7        |
      Autolysis                            |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   1        |
      Autolysis                            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Autolysis                            |                                                                          |      2  2.5|
      Basophilic Focus, Multiple           |                                                                          |      2     |
      Clear Cell Focus                     |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                                                          |      6     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      2  2.0|
      Infarct                              |                                                                          |      1  1.0|
      Leukocytosis                         |                                                                          |      7  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      5  1.8|
      Bile Duct, Hyperplasia               |                                                                          |     14  1.2|
      Hepatocyte, Degeneration, Cystic     |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |   3        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Atrium Left, Thrombosis              |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |   2        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  16        |
      Pars Distalis, Ectasia               |                                                                          |      1  4.0|
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Hyperplasia                  |                                                                          |     19  1.8|
      Follicle, Cyst                       |                                                                          |      2  2.0|
      Follicle, Dilatation                 |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia, Cystic |                                                                          |      5  1.8|
      Follicular Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   9        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |   3        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   2        |
      Dilatation                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  44        |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |   2        |
      Myeloid Cell, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   7        |
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Re Cell     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Autolysis                            |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      3  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      2  3.5|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  46        |
      Cyst                                 |                                                                          |      1  4.0|
      Galactocele                          |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      7  1.4|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Duct, Ectasia                        |                                                                          |     12  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  14        |
      Acanthosis                           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Cyst            |                                                                          |      1  3.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  1.0|
      Tail, Acanthosis                     |                                                                          |      4  2.8|
      Tail, Hyperkeratosis                 |                                                                          |      4  2.8|
      Tail, Inflammation, Acute            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05021-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         CI PIGMENT RED 23                                     Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 11:48:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 7| 6| 6| 7| 7| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.0%                                   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |   3        |
      Compression                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |   6        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |   1        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Inflammation, Chronic        |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  48        |
      Autolysis                            |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Nephropathy                          |                                                                          |     48  2.8|
      Renal Tubule, Hyperplasia            |                                                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.