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https://ntp.niehs.nih.gov/go/2747

TDMS Study 05024-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                        N-METHYLOLACRYLAMIDE


NTP Experiment-Test: 05024-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 04:40:23




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  924-42-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05024-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:23  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               5            9           10                                                  
    Moribund                                           3            6            6                                                  
    Accident                                           1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           35           33                                                  
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    50           50           49                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (45)         (6)          (44)                                                
      Infarct                                                                    1 (2%)                                             
      Parasite Metazoan                                                          1 (2%)                                             
   Intestine Large, Rectum                            (46)         (6)          (43)                                                
      Parasite Metazoan                                                          1 (2%)                                             
   Intestine Small, Duodenum                          (44)         (5)          (41)                                                
      Inflammation, Chronic Active                                  1 (20%)                                                         
      Ulcer                                                         1 (20%)                                                         
   Intestine Small, Ileum                             (44)         (4)          (43)                                                
      Inflammation, Necrotizing                                                  1 (2%)                                             
   Intestine Small, Jejunum                           (45)         (4)          (42)                                                
      Necrosis, Coagulative                                                      1 (2%)                                             
   Liver                                              (50)         (50)         (49)                                                
      Amyloid Deposition                                            1 (2%)                                                          
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Atypia Cellular                                               2 (4%)                                                          
      Clear Cell Focus                                                           2 (4%)                                             
      Degeneration, Cystic                                          1 (2%)                                                          
      Hematopoietic Cell Proliferation                              4 (8%)       2 (4%)                                             
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Leukocytosis                                     1 (2%)       2 (4%)       1 (2%)                                             
      Necrosis, Coagulative                                         4 (8%)       3 (6%)                                             
      Pigmentation, Hematoidin                                                   1 (2%)                                             
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Vacuolization Cytoplasmic                        1 (2%)                    2 (4%)                                             
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Bile Duct, Cyst                                                            1 (2%)                                             
   Mesentery                                          (48)         (6)          (47)                                                
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
      Necrosis                                                                   2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05024-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:23  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Thrombosis                                                                 2 (4%)                                             
   Pancreas                                           (50)         (6)          (47)                                                
      Inflammation, Chronic Active                                               2 (4%)                                             
      Acinus, Atrophy                                  3 (6%)       1 (17%)      4 (9%)                                             
      Duct, Ectasia                                    1 (2%)                                                                       
   Stomach, Forestomach                               (46)         (6)          (44)                                                
      Acanthosis                                       3 (7%)                    5 (11%)                                            
      Hyperkeratosis                                   1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (47)         (5)          (44)                                                
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
   Tooth                                              (50)         (6)          (48)                                                
      Dysplasia                                        1 (2%)                    3 (6%)                                             
      Foreign Body                                                               1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (6)          (49)                                                
      Cardiomyopathy, Chronic                          1 (2%)                    4 (8%)                                             
      Inflammation, Chronic Active                                               2 (4%)                                             
      Mineralization                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (7)          (48)                                                
      Corticomedullary Junction, Degeneration,                                                                                      
           Fatty                                                                 1 (2%)                                             
   Adrenal Gland, Cortex                              (50)         (6)          (47)                                                
      Accessory Adrenal Cortical Nodule                                          3 (6%)                                             
      Cyst                                                                       1 (2%)                                             
      Hematopoietic Cell Proliferation                              2 (33%)      1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Hypertrophy                                      1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (7)          (48)                                                
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia                                      5 (10%)                   2 (4%)                                             
   Islets, Pancreatic                                 (50)         (6)          (47)                                                
      Hyperplasia                                                                2 (4%)                                             
   Parathyroid Gland                                  (31)         (5)          (28)                                                
      Cyst                                                                       1 (4%)                                             
   Pituitary Gland                                    (49)         (14)         (43)                                                
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      22 (45%)      4 (29%)     13 (30%)                                            
   Thyroid Gland                                      (48)         (6)          (48)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05024-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:23  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
      C-Cell, Hyperplasia                              1 (2%)                    1 (2%)                                             
      Follicle, Cyst                                   1 (2%)                    3 (6%)                                             
      Follicular Cell, Hyperplasia                     9 (19%)                  11 (23%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (45)         (47)                                                
      Atrophy                                          3 (6%)      39 (87%)     38 (81%)                                            
      Cyst                                            10 (20%)      9 (20%)      6 (13%)                                            
      Hemorrhage, Acute                                                          2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
   Uterus                                             (50)         (35)         (49)                                                
      Dilatation                                                    2 (6%)       4 (8%)                                             
      Hemorrhage                                                    5 (14%)      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                    2 (4%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Artery, Hyperplasia, Cystic, Glandular                        1 (3%)                                                          
      Endometrium, Hyperplasia, Cystic, Glandular     47 (94%)     31 (89%)     45 (92%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                           (2)                                                              
      Neutrophilia                                                  2 (100%)                                                        
   Bone Marrow                                        (50)         (6)          (48)                                                
      Femoral, Hyperplasia                                          2 (33%)      1 (2%)                                             
      Femoral, Hyperplasia, Reticulum Cell             1 (2%)                                                                       
      Femoral, Myelofibrosis                           3 (6%)                    1 (2%)                                             
      Vertebral, Hyperplasia                                                     1 (2%)                                             
      Vertebral, Myelofibrosis                        29 (58%)                  10 (21%)                                            
   Lymph Node                                         (50)         (13)         (46)                                                
      Iliac, Thrombosis                                                          1 (2%)                                             
      Lumbar, Hyperplasia, Lymphoid                    1 (2%)                                                                       
      Mandibular, Hematopoietic Cell Proliferation                  2 (15%)      1 (2%)                                             
      Mandibular, Hyperplasia, Plasma Cell                                       3 (7%)                                             
      Mandibular, Infiltration Cellular, Histiocyte                              1 (2%)                                             
      Renal, Hyperplasia, Lymphoid                                  1 (8%)                                                          
      Renal, Thrombosis                                                          1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05024-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:23  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mesenteric                             (11)         (7)          (13)                                                
      Angiectasis                                                                3 (23%)                                            
      Hematopoietic Cell Proliferation                 1 (9%)       1 (14%)                                                         
      Hyperplasia, Lymphoid                                         1 (14%)                                                         
      Hyperplasia, Plasma Cell                                                   1 (8%)                                             
      Thrombosis                                                                 1 (8%)                                             
   Spleen                                             (50)         (19)         (48)                                                
      Cyst                                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                15 (30%)     10 (53%)     40 (83%)                                            
      Hyperplasia, Lymphoid                                         1 (5%)                                                          
      Infarct                                                                    1 (2%)                                             
   Thymus                                             (48)         (4)          (38)                                                
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (29)         (48)         (33)                                                
      Hyperplasia                                      1 (3%)                                                                       
      Hyperplasia, Cystic                             20 (69%)     40 (83%)     29 (88%)                                            
   Skin                                               (50)         (14)         (48)                                                
      Abscess                                                       1 (7%)                                                          
      Alopecia                                                      1 (7%)                                                          
      Foreign Body                                                  1 (7%)       1 (2%)                                             
      Inflammation, Chronic Active                                  1 (7%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (50)         (6)          (48)                                                
      Fibrosis, Focal                                                            1 (2%)                                             
      Hemorrhage, Acute                                1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (7)          (48)                                                
      Hemorrhage, Acute                                                          1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
   Peripheral Nerve                                   (47)         (43)         (42)                                                
      Sciatic, Degeneration                                         4 (9%)                                                          
   Spinal Cord                                        (50)         (6)          (49)                                                
      White Matter, Degeneration                       5 (10%)      1 (17%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05024-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:23  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)                                                
      Hemorrhage, Acute                                             1 (2%)       1 (2%)                                             
      Inflammation, Chronic                           12 (24%)     28 (56%)     14 (29%)                                            
      Pigmentation, Hemosiderin                                                  3 (6%)                                             
      Alveolar Epithelium, Hyperplasia                 8 (16%)     26 (52%)     17 (35%)                                            
   Nose                                               (50)         (6)          (48)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Nasolacrimal Duct, Foreign Body                                            1 (2%)                                             
      Nasolacrimal Duct, Granuloma                                               1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)                    5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (2)                                                 
      Lens, Cataract                                                             2 (100%)                                           
      Retina, Atrophy                                                            2 (100%)                                           
   Harderian Gland                                    (47)         (45)         (48)                                                
      Hyperplasia                                      1 (2%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (11)         (48)                                                
      Amyloid Deposition                                            1 (9%)                                                          
      Atrophy                                                       1 (9%)                                                          
      Hydronephrosis                                                             1 (2%)                                             
      Infarct                                                                    5 (10%)                                            
      Inflammation                                                  1 (9%)                                                          
      Metaplasia, Osseous                              2 (4%)                    3 (6%)                                             
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Nephropathy, Chronic                            10 (20%)      3 (27%)     23 (48%)                                            
      Renal Tubule, Regeneration                                                 1 (2%)                                             
   Urinary Bladder                                    (43)         (6)          (47)                                                
      Hemorrhage                                                    1 (17%)                                                         
      Inflammation, Chronic Active                     1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05024-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:23  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          12           14           10                                                  
    Dead                                               8           16           19                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           20           20                                                  
    Moribund                                                                     1                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (44)         (12)         (33)                                                
      Inflammation, Chronic Active                     1 (2%)                    1 (3%)                                             
   Intestine Large, Colon                             (45)         (16)         (43)                                                
      Parasite Metazoan                                                          1 (2%)                                             
   Intestine Large, Rectum                            (43)         (11)         (42)                                                
      Parasite Metazoan                                                          1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Basophilic Focus                                 1 (2%)                                                                       
      Clear Cell Focus                                                           1 (2%)                                             
      Cyst                                                          1 (2%)                                                          
      Hematopoietic Cell Proliferation                              2 (4%)       1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       2 (4%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Necrotizing                                     1 (2%)                                                          
      Leukocytosis                                     2 (4%)                    3 (6%)                                             
      Mineralization                                   1 (2%)                                                                       
      Necrosis, Coagulative                            5 (10%)      3 (6%)       8 (16%)                                            
      Pigmentation, Hematoidin                         1 (2%)                                                                       
      Vacuolization Cytoplasmic                                                  2 (4%)                                             
   Mesentery                                          (43)         (18)         (49)                                                
      Inflammation, Chronic Active                     1 (2%)                    3 (6%)                                             
      Necrosis                                                                   1 (2%)                                             
   Pancreas                                           (49)         (21)         (47)                                                
      Cyst                                                          1 (5%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
      Necrosis, Coagulative                                         1 (5%)       1 (2%)                                             
      Acinus, Atrophy                                  1 (2%)                                                                       
   Salivary Glands                                    (49)         (20)         (50)                                                
      Inflammation, Chronic Active                                  1 (5%)                                                          
      Necrosis, Coagulative                                                      1 (2%)                                             
   Stomach, Forestomach                               (50)         (49)         (48)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05024-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:23  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acanthosis                                      20 (40%)     23 (47%)     26 (54%)                                            
      Acanthosis, Multiple                                                       1 (2%)                                             
      Hyperkeratosis                                   4 (8%)       1 (2%)       8 (17%)                                            
      Inflammation, Chronic Active                     2 (4%)       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (20)         (45)                                                
      Cyst                                                          1 (5%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
   Tooth                                              (50)         (20)         (50)                                                
      Dysplasia                                        2 (4%)                    8 (16%)                                            
      Foreign Body                                                               1 (2%)                                             
      Inflammation, Chronic Active                     4 (8%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (47)         (19)         (34)                                                
      Mesenteric Artery, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)                                                                       
      Mesenteric Artery, Necrosis, Fibrinoid           1 (2%)                                                                       
      Pulmonary Artery, Inflammation, Chronic                                                                                       
          Active                                       1 (2%)                                                                       
      Pulmonary Artery, Necrosis, Fibrinoid            1 (2%)                                                                       
      Renal Artery, Inflammation, Chronic Active       1 (2%)                                                                       
      Renal Artery, Necrosis, Fibrinoid                1 (2%)                                                                       
      Renal Artery, Thrombosis                         1 (2%)                                                                       
      Thoracic, Inflammation, Chronic Active           1 (2%)                                                                       
      Thoracic, Necrosis, Fibrinoid                    1 (2%)                                                                       
   Heart                                              (50)         (20)         (50)                                                
      Cardiomyopathy, Chronic                                                    4 (8%)                                             
      Inflammation, Suppurative                                                  2 (4%)                                             
      Mineralization                                   1 (2%)                                                                       
      Atrium, Thrombosis                               1 (2%)                                                                       
      Coronary Artery, Inflammation, Chronic Active    1 (2%)                                                                       
      Coronary Artery, Necrosis, Fibrinoid             1 (2%)                                                                       
      Valve, Bacterium                                 1 (2%)       2 (10%)      4 (8%)                                             
      Valve, Inflammation, Suppurative                              2 (10%)                                                         
      Valve, Thrombosis                                1 (2%)       2 (10%)      5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (21)         (48)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                    2 (4%)                                             
      Hyperplasia                                      2 (4%)       1 (5%)       1 (2%)                                             
      Hypertrophy                                      3 (6%)                    5 (10%)                                            
   Adrenal Gland, Medulla                             (48)         (20)         (50)                                                
      Hyperplasia                                      3 (6%)       1 (5%)       5 (10%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05024-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:23  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Islets, Pancreatic                                 (50)         (19)         (47)                                                
      Hyperplasia                                                                2 (4%)                                             
   Pituitary Gland                                    (48)         (14)         (42)                                                
      Pars Distalis, Cyst                              2 (4%)                    2 (5%)                                             
      Pars Distalis, Hyperplasia                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (20)         (49)                                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis, Fibrinoid                              1 (2%)                                                                       
      Ultimobranchial Cyst                                          1 (5%)                                                          
      Follicular Cell, Hyperplasia                     1 (2%)                    5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (26)         (18)         (46)                                                
      Dilatation                                                                 2 (4%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
   Epididymis                                         (50)         (20)         (50)                                                
      Inflammation, Chronic Active                                  1 (5%)                                                          
   Penis                                              (3)          (2)          (4)                                                 
      Inflammation, Chronic Active                                  1 (50%)      1 (25%)                                            
      Mineralization                                   1 (33%)                                                                      
   Preputial Gland                                    (3)          (9)          (6)                                                 
      Inflammation, Chronic Active                     3 (100%)     1 (11%)      4 (67%)                                            
      Duct, Ectasia                                                 1 (11%)                                                         
      Lymphatic, Ectasia                                            1 (11%)      1 (17%)                                            
   Prostate                                           (49)         (20)         (50)                                                
      Inflammation, Chronic Active                     4 (8%)       3 (15%)      1 (2%)                                             
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
   Seminal Vesicle                                    (29)         (18)         (36)                                                
      Dilatation                                       5 (17%)      1 (6%)       4 (11%)                                            
      Inflammation, Chronic Active                     2 (7%)       1 (6%)       1 (3%)                                             
      Inflammation, Suppurative                        1 (3%)                                                                       
   Testes                                             (50)         (20)         (50)                                                
      Mineralization                                                1 (5%)                                                          
      Interstitial Cell, Hyperplasia                   1 (2%)       1 (5%)                                                          
      Seminiferous Tubule, Atrophy                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05024-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:23  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (3)          (2)                                                              
      Neutrophilia                                     1 (33%)      2 (100%)                                                        
   Bone Marrow                                        (50)         (20)         (50)                                                
      Femoral, Hyperplasia                             2 (4%)       3 (15%)      6 (12%)                                            
   Lymph Node                                         (49)         (32)         (50)                                                
      Hematopoietic Cell Proliferation                              1 (3%)                                                          
      Axillary, Hemorrhage, Acute                                                1 (2%)                                             
      Axillary, Hyperplasia, Lymphoid                                            1 (2%)                                             
      Lumbar, Hyperplasia, Plasma Cell                              1 (3%)                                                          
      Mandibular, Hematopoietic Cell Proliferation                  1 (3%)                                                          
      Mandibular, Hyperplasia                                       1 (3%)                                                          
      Mandibular, Hyperplasia, Lymphoid                1 (2%)                    1 (2%)                                             
      Mandibular, Hyperplasia, Plasma Cell             1 (2%)                    3 (6%)                                             
      Mandibular, Inflammation, Suppurative            1 (2%)                                                                       
      Mandibular, Necrosis                             1 (2%)                                                                       
      Mediastinal, Inflammation, Suppurative           2 (4%)                                                                       
      Renal, Hematopoietic Cell Proliferation                       1 (3%)                                                          
   Lymph Node, Mesenteric                             (19)         (17)         (24)                                                
      Angiectasis                                     10 (53%)     10 (59%)     14 (58%)                                            
      Hematopoietic Cell Proliferation                11 (58%)     11 (65%)     10 (42%)                                            
      Hyperplasia, Lymphoid                            1 (5%)                    1 (4%)                                             
      Hyperplasia, Reticulum Cell                      1 (5%)                                                                       
   Spleen                                             (50)         (26)         (50)                                                
      Depletion Lymphoid                               2 (4%)                                                                       
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                11 (22%)     13 (50%)     38 (76%)                                            
      Infarct                                                                    2 (4%)                                             
      Necrosis                                         1 (2%)       1 (4%)                                                          
   Thymus                                             (36)         (13)         (39)                                                
      Cyst                                             3 (8%)                                                                       
      Necrosis                                         1 (3%)       6 (46%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (33)         (50)                                                
      Abscess                                                       2 (6%)                                                          
      Acanthosis                                       3 (6%)                    1 (2%)                                             
      Alopecia                                         1 (2%)                                                                       
      Edema                                                                      1 (2%)                                             
      Fibrosis                                         1 (2%)                    2 (4%)                                             
      Hyperkeratosis                                   2 (4%)                    1 (2%)                                             
      Inflammation, Chronic Active                     7 (14%)      9 (27%)      6 (12%)                                            
      Inflammation, Suppurative                        1 (2%)       1 (3%)       2 (4%)                                             
      Metaplasia, Osseous                                           1 (3%)                                                          
      Necrosis, Coagulative                            1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05024-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:23  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Lymphatic, Ectasia                               1 (2%)                                                                       
      Prepuce, Concretion                                           1 (3%)                                                          
      Prepuce, Dilatation                                           1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (34)         (50)                                                
      Joint, Femur, Tibia, Metaplasia, Osseous         1 (2%)       1 (3%)                                                          
      Joint, Tarsal, Metaplasia, Osseous              24 (48%)     16 (47%)     11 (22%)                                            
      Sternum, Developmental Malformation                           1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (20)         (50)                                                
      Hemorrhage, Acute                                1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Artery, Cerebrum, Necrosis, Fibrinoid            1 (2%)                                                                       
   Peripheral Nerve                                   (47)         (39)         (43)                                                
      Sciatic, Degeneration                                         1 (3%)       3 (7%)                                             
   Spinal Cord                                        (48)         (20)         (49)                                                
      White Matter, Degeneration                       2 (4%)                    3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)                                                
      Hemorrhage, Acute                                2 (4%)                    2 (4%)                                             
      Inflammation, Chronic                            8 (16%)     12 (24%)     20 (40%)                                            
      Leukocytosis                                     1 (2%)       1 (2%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                10 (20%)     17 (34%)     19 (38%)                                            
   Nose                                               (50)         (20)         (50)                                                
      Foreign Body                                                  1 (5%)                                                          
      Granuloma                                                     1 (5%)                                                          
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative     3 (6%)       1 (5%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)          (4)                                                 
      Cornea, Inflammation, Chronic Active                                       1 (25%)                                            
      Lens, Cataract                                                2 (100%)     1 (25%)                                            
      Retina, Atrophy                                               1 (50%)                                                         
   Harderian Gland                                    (48)         (49)         (50)                                                
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05024-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:23  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (22)         (50)                                                
      Atrophy                                                                    1 (2%)                                             
      Bacterium                                                     1 (5%)                                                          
      Cyst                                                                       1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hydronephrosis                                   1 (2%)       1 (5%)                                                          
      Infarct                                          2 (4%)       3 (14%)      8 (16%)                                            
      Inflammation, Suppurative                        3 (6%)       3 (14%)      1 (2%)                                             
      Mineralization                                                3 (14%)      8 (16%)                                            
      Nephropathy, Chronic                            21 (42%)      4 (18%)     22 (44%)                                            
      Thrombosis                                                                 1 (2%)                                             
      Artery, Inflammation, Chronic Active             2 (4%)                                                                       
      Artery, Necrosis, Fibrinoid                      2 (4%)                                                                       
   Ureter                                             (39)         (15)         (38)                                                
      Inflammation, Chronic Active                     1 (3%)                                                                       
      Inflammation, Suppurative                        1 (3%)                                                                       
   Urethra                                            (30)         (8)          (35)                                                
      Concretion                                       2 (7%)       4 (50%)                                                         
      Inflammation, Chronic Active                     1 (3%)       2 (25%)      1 (3%)                                             
      Inflammation, Suppurative                                                  1 (3%)                                             
   Urinary Bladder                                    (49)         (21)         (49)                                                
      Dilatation                                       3 (6%)       8 (38%)      2 (4%)                                             
      Inflammation, Chronic Active                     2 (4%)       1 (5%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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