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TDMS Study 05024-02 Pathology Tables

NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97
Route: GAVAGE                                                                                                     Time: 12:53:11




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  924-42-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                  X                                       |             
      Hemangioma, Multiple                 |                                                                          |             
      Hemangiosarcoma                      |                                           X                              |             
      Hepatocellular Carcinoma             |                                  X           X                           |             
      Hepatocellular Adenoma               |                      X                                                   |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Lymphoma Malignant Histiocytic       |    X  X                                                                  |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X        X                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X        X                                                      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +              +  +  +  +        +  +  +  +        +  +        +     +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  M  +  M  M  M  +  M  +  +  M  M  M  +  +  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                  X     X  X                              |             
      Pars Distalis, Adenoma, Multiple     |                X                                                         |             
      Pars Intermedia, Carcinoma           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Bilateral, Follicular Cell, Adenoma, |                                                                          |             
           Multiple                        |                                           X                              |             
      Follicular Cell, Adenoma             |    X                 X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  +     +  +     +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                              X                           |             
      Polyp Stromal                        |                                                          X               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Histiocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                          X               |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |             X                                                            |             
      Mandibular, Lymphoma Malignant Mixed |          X        X                                                      |             
      Mediastinal, Hepatocellular          |                                                                          |             
          Carcinoma, Metastatic, Liver     |                                  X                                       |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |       X                                                                  |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|          X        X                                                      |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  M  M  +  +  M  M  M  +  A  M  M  M  M  M  M  M  +  M  M  M  M  M|             
      Lymphoma Malignant Histiocytic       |    X  X                                                  X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |    X  X                                                  X               |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |          X        X                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |       X                                                  X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X        X                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  M  +  M  +  +  +  +  +  M  +  +  M  M  +  +  M  M  M  M  M|             
      Adenocarcinoma                       |                                  X                                       |             
      Adenoma                              |                               X                          X               |             
      Fibroadenoma                         |                                  X                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sebaceous Gland, Adenoma             |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                X                                               X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                  X                                       |             
      Alveolar/Bronchiolar Adenoma         |       X                 X                                                |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                  X                                       |             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
      Mediastinum, Hemangiosarcoma         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                   X                       X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |          X        X                                                      |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                              +  +              +  +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M     +  +  +     +  +|             
      Lymphoma Malignant Histiocytic       |       X                                                                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |    X  X                                                  X               |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |          X        X                                                      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|            |
                                           | 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A|  45        |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  46        |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  44        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  45        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Hemangioma, Multiple                 |                                                                      X   |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                       X                  |          3 |
      Hepatocellular Adenoma               |                                                    X                     |          2 |
      Hepatocellular Adenoma, Multiple     |                                                                   X      |          1 |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          3 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hemangiosarcoma                      |                                                                X         |          1 |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Lymphocytic       |                               X                 X        X           X   |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|            |
                                           | 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +     +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +        +     +  +  +  +  +  +                 +        +     +  +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Mixed             |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  M  M  +  +  M  +  M  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Pars Distalis, Adenoma               |                   X  X     X           X              X  X  X  X  X      |         12 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
      Pars Intermedia, Carcinoma           |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Bilateral, Follicular Cell, Adenoma, |                                                                          |            |
           Multiple                        |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                       X                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |    +  +  +  +  +        +  +     +  +  +     +     +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|            |
                                           | 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemangiosarcoma                      |                                                                          |          1 |
      Polyp Stromal                        |                X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Histiocytic                      |                                  X                                       |          1 |
      Inguinal, Lymphoma Malignant Mixed   |       X                                                                  |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                               X                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |       X                                                                  |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                  X                                       |          2 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                               X              X  X                    X   |          5 |
      Mandibular, Lymphoma Malignant Mixed |       X                                                                  |          3 |
      Mediastinal, Hepatocellular          |                                                                          |            |
          Carcinoma, Metastatic, Liver     |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                  X                                       |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                               X                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Renal, Lymphoma Malignant Histiocytic|                                  X                                       |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                               X                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  +  M  M  M  M  M  M  M  +  +  M  M  +  M  M  M  M  M  M  M  +  M  M|  11        |
      Lymphoma Malignant Histiocytic       |                                  X                                X      |          5 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                  X                                X      |          5 |
      Lymphoma Malignant Lymphocytic       |          X                    X              X  X        X           X   |          7 |
      Lymphoma Malignant Mixed             |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          3 |
      Lymphoma Malignant Lymphocytic       |                               X              X  X        X           X   |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|            |
                                           | 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |       X                                                                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  M  +  M  M  +  +  +|  29        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                                                                          |          2 |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sebaceous Gland, Adenoma             |                                                       X                  |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Lymphocytic       |                               X                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                        X                             X   |          4 |
      Alveolar/Bronchiolar Carcinoma       |                            X                          X                  |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                  X                                X      |          3 |
      Lymphoma Malignant Lymphocytic       |          X                    X                 X        X           X   |          5 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mediastinum, Hemangiosarcoma         |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|            |
                                           | 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Adenoma                              |       X        X                                               X         |          5 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Lymphocytic       |                               X                 X                    X   |          4 |
      Lymphoma Malignant Mixed             |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                   +                 +  +  M     +  +           +         |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A|  43        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                               X                 X                        |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                  X                                X      |          5 |
      Lymphoma Malignant Lymphocytic       |          X                    X              X  X        X           X   |          7 |
      Lymphoma Malignant Mixed             |       X                       X                                          |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|             
                                           | 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +                          +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                               A                          +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +                       +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               M                       +  +               |             
      Leiomyoma                            |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +                          +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +                          +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +                          +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +                          +               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               M                          +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               M                          +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Metastatic, Skin    |                X                                                         |             
      Hepatocellular Carcinoma             |          X                                   X                           |             
      Hepatocellular Adenoma               |                               X           X                              |             
      Hepatocellular Adenoma, Multiple     |                   X                                                      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X                    X                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                          +               |             
      Lymphoma Malignant                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +                          +               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                            +  +                          +               |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +                          +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +                          +               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               A                          +               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                          +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +                          +               |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +                          +               |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +                          +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +                          +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +                          +               |             
      Pheochromocytoma Benign              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|             
                                           | 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +                          +               |             
      Lymphoma Malignant                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               M                          +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +     +              +  +                       +           +  +|             
      Pars Distalis, Adenoma               |                                  X                                   X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +                          +               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                        +                                 |             
      Adenocarcinoma                       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  I  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                           X        X                     |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                               +                          +               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +  +  +  +  +     +  +  +  +     +  +  +        +     +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Leiomyoma                            |                                                                          |             
      Polyp Stromal                        |                         X                                                |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +                          +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +              +  +                          +  +            |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                            X                                             |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                            X                                X            |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                            X                                             |             
      Lumbar, Lymphoma Malignant           |                               X                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                            X                                             |             
      Mandibular, Lymphoma Malignant       |                               X                                          |             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                          X               |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|             
                                           | 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                            X                                             |             
      Mediastinal, Lymphoma Malignant      |                               X                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                               X                                          |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                            X                                             |             
      Renal, Lymphoma Malignant            |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +              +  +                          M               |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +  +  +     +     +  A                 +        +  +  +  +      |             
      Hemangiosarcoma, Metastatic, Skin    |                      X                                                   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X                    X           X  X         |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               M                          M               |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoacanthoma                       |                                                                          |             
      Adenoma                              |       X                       X                                      X   |             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +  +     +     +  +                          +           +   |             
      Lymphoma Malignant                   |                               X                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |             X  X     X                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                               +                          +               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                          +               |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant                   |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                       +                          +               |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  I  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                               +                          +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoacanthoma, Metastatic, Mammary  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|             
                                           | 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                         X                                                |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                     X                                    |             
      Alveolar/Bronchiolar Carcinoma       |                   X              X  X                                    |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                          X               |             
      Basosquamous Tumor Malignant         |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Hemangiosarcoma, Metastatic, Skin    |                X                                                         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |          X                                                               |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +                          +               |             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +                          +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              |             X                             X           X           X      |             
      Adenoma, Multiple                    |                                              X                           |             
      Carcinoma                            |                                  X                                       |             
      Bilateral, Adenoma                   |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +              +  +                          +  +            |             
      Lymphoma Malignant Lymphocytic       |                            X                                X            |             
      Lymphoma Malignant                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +                          +               |             
      Lymphoma Malignant                   |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                               X                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X                    X           X  X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3|            |
                                           | 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                             A     +                    +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                             +     +                    +               |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                             A     +                    +               |   5        |
      Leiomyoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                             A     +                    +               |   5        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                             A     +                    +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                             A     +                    +               |   4        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                              X                           |          1 |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                   X      |          3 |
      Hepatocellular Adenoma               |                   X                                                      |          3 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                              X                       X   |          2 |
      Lymphoma Malignant Lymphocytic       | X                                X                                       |          4 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                             +     +                    +               |   6        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                             +     +                    +               |   6        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                             +     +                    +               |   7        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                             +     +                    +               |   5        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +                             +     +                    +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                             +     +                    +               |   6        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3|            |
                                           | 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                 +           +     +                    +               |   7        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                 +           +     +                    +               |   7        |
      Pheochromocytoma Benign              |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                             +     +                    +               |   6        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                             +     +                    +               |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                    +     +  +     +              +     +               |  14        |
      Pars Distalis, Adenoma               |                      X     X                       X                     |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                             +     +                    +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  I  M  +|  45        |
      Granulosa Cell Tumor Benign          |    X                 X                                         X         |          5 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +  +  +     +           +  +     +  +  +  +      |  35        |
      Hemangioma                           |                            X                                             |          1 |
      Hemangiosarcoma                      |                               X                                          |          1 |
      Leiomyoma                            |          X                                                               |          1 |
      Polyp Stromal                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                               +              +                           |   2        |
      Lymphoma Malignant Histiocytic       |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +                                   +                                    |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                          +  +  +  +        +           +           +   |  13        |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3|            |
                                           | 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                  X                                       |          2 |
      Lumbar, Lymphoma Malignant           |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                  X                                       |          2 |
      Mandibular, Lymphoma Malignant       |                                                                          |          1 |
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                      X   |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      | X                                                                        |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |          1 |
      Renal, Lymphoma Malignant Histiocytic|                                                                      X   |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                  X                                       |          2 |
      Renal, Lymphoma Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                             M  +  M        +           M           +   |   7        |
      Lymphoma Malignant Histiocytic       |                                                                      X   |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                    +        +  +  +        +           +           +  +|  19        |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                      X   |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                      X|          6 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                          +  M     +                    +           +   |   4        |
      Lymphoma Malignant Histiocytic       |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|  48        |
      Adenoacanthoma                       |                                     X                                    |          1 |
      Adenoma                              |                                  X                                       |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                             +  +  +                    +        +      |  14        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                          X        X      |          2 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3|            |
                                           | 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                             +     +                    +               |   6        |
      Fibrosarcoma, Metastatic, Skin       |                                                          X               |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                             +     +                    +               |   7        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  M|  43        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                             +     +                    +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoacanthoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                     X                                    |          1 |
      Alveolar/Bronchiolar Adenoma         |                   X              X                                       |          3 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                   X      |          4 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Basosquamous Tumor Malignant         |                                     X                                    |          1 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                  X                                       |          1 |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                      X   |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                             +     +                    +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  45        |
      Adenoma                              |                                                 X                 X      |          6 |
      Adenoma, Multiple                    |                                                                          |          1 |
      Carcinoma                            |                                  X     X                                 |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3|            |
                                           | 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Adenoma                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                 +           +  +  +                    +               |  11        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                             M     +        +           +               |   6        |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                              X                       X   |          2 |
      Lymphoma Malignant Lymphocytic       | X                                X                                      X|          7 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|             
                                           | 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  A  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     A  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     A  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     A  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     A  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     A  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     A  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                      X   |             
      Hepatocellular Adenoma               |             X  X        X     X                 X              X         |             
      Hepatocellular Adenoma, Multiple     |                                                                      X   |             
      Lymphoma Malignant Histiocytic       |                                              X                    X      |             
      Lymphoma Malignant Lymphocytic       |                      X                    X                              |             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +        +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |    X                             X                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                    X                              |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Squamous Cell Papilloma              |                                                       X           X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                              +                           |             
      Squamous Cell Papilloma              |                                              X                           |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +        +  +     +  +        +  +     +     +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|             
                                           | 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Capsule, Carcinoma                   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  +  M     +  +  M  M  +  +  +  +  M  M  +  +  M  M  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +     M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Adenoma               |    X                                X                    X               |             
      Pars Intermedia, Adenoma             |                                  X                                       |             
      Pars Intermedia, Carcinoma           |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Follicular Cell, Adenoma             |                                     X                                X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                        +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                        X              X              X   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                    X                             X|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 | +  +  A  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hemangiosarcoma             |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|             
                                           | 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                                                                   X      |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Vertebral, Hemangiosarcoma           |                                                 X                        |             
      Vertebral, Lymphoma Malignant        |                                                                          |             
          Histiocytic                      |                                                                          |             
      Vertebral, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Vertebral, Lymphoma Malignant Mixed  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M  M  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                      X                                                   |             
      Iliac, Lymphoma Malignant Mixed      |                                  X                                       |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                   X      |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |             X        X                    X              X              X|             
      Mandibular, Lymphoma Malignant Mixed |                         X        X                                       |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |             X        X                                                   |             
      Mediastinal, Lymphoma Malignant Mixed|    X                             X              X                        |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |    X                                                                     |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  M  M  M  M     +  +  M  M  +  M  M  M  M  +  M  M  M  M  M  +  M  +|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                      X                                                  X|             
      Lymphoma Malignant Mixed             |    X                    X        X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                 X                        |             
      Lymphoma Malignant Histiocytic       |                                              X                    X      |             
      Lymphoma Malignant Lymphocytic       |             X        X                    X              X              X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|             
                                           | 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |    X                    X        X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  M  M     +  +  +  +  M  +  M  +  M  M  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                   X               |             
      Lymphoma Malignant Mixed             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Adenoacanthoma                       |       X                                                                  |             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |    X                          X                                         X|             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hemangiosarcoma                      |                                                 X                        |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                           X                              |             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Meningioma Benign                    |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  M  M  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Sciatic, Lymphoma Malignant Mixed    |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                        X  X                 X            |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                              X                           |             
      Alveolar/Bronchiolar Carcinoma       |                            X                       X  X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|             
                                           | 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                      X   |             
      Lymphoma Malignant Histiocytic       |                                              X                    X      |             
      Lymphoma Malignant Lymphocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |             X                                                            |             
      Mediastinum, Lymphoma Malignant Mixed|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                             +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X     X  X                    X                          X|             
      Adenoma, Multiple                    |                                                 X                        |             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   | X           X                 X           X                    X         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |             X        X                    X              X               |             
      Lymphoma Malignant Mixed             |    X                    X                                                |             
                                            __________________________________________________________________________|             
   Ureter                                  | +        +     +        +        +  +  +     +  +        +        +  +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                              X                    X      |             
      Lymphoma Malignant Lymphocytic       |             X        X                    X              X              X|             
      Lymphoma Malignant Mixed             |    X                    X        X              X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3|            |
                                           | 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  A  A  +  +  +  +  +  +  +  M  +  +  A  +  A  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  43        |
      Lymphoma Malignant Mixed             |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +|  41        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  42        |
      Lymphoma Malignant Histiocytic       |                                              X                           |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Carcinoma             |                                  X                                       |          2 |
      Hepatocellular Adenoma               |          X           X  X  X  X                 X     X           X  X   |         15 |
      Hepatocellular Adenoma, Multiple     |                                  X                                       |          2 |
      Lymphoma Malignant Histiocytic       |                   X     X                    X           X               |          6 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosarcoma, Metastatic, Skin       |                                                             X            |          1 |
      Lymphoma Malignant Histiocytic       |                   X                          X                           |          2 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          2 |
      Lymphoma Malignant Mixed             |                         X           X                                    |          4 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosarcoma, Metastatic, Skin       |                                                             X            |          1 |
      Lymphoma Malignant Histiocytic       |                                                          X               |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
      Lymphoma Malignant Mixed             |                         X           X                                X   |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          2 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3|            |
                                           | 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +     +  +  +  +  +  +        +  +  +  +  +     +     +     +  +     +|  34        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                X                                                         |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Histiocytic       |                                              X                           |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Capsule, Carcinoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                   X                              |          2 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  M  +  +  M  +  +  +  +  M  M  +  +  M  +  M  +  M  +  +  +  +|  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|  43        |
      Pars Distalis, Adenoma               |    X                                                                     |          4 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
      Pars Intermedia, Carcinoma           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
      Follicular Cell, Adenoma             |                                                                         X|          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                +                                                         |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Granulosa Cell Tumor Benign          |             X                             X                              |          5 |
      Lymphoma Malignant Histiocytic       |                   X                          X           X               |          3 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3|            |
                                           | 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +  +     +  +        +     +  +        +  +  +        +  +     +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X           X                                    |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Femoral, Hemangiosarcoma             |                                                                          |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
      Vertebral, Hemangiosarcoma           |                                                                          |          1 |
      Vertebral, Lymphoma Malignant        |                                                                          |            |
          Histiocytic                      |                   X                                      X               |          2 |
      Vertebral, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
      Vertebral, Lymphoma Malignant Mixed  |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                                          X               |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |       X                                                                  |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |       X                                                                  |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                   X                                      X               |          3 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |       X  X                                                               |          7 |
      Mandibular, Lymphoma Malignant Mixed |                         X        X  X     X                          X   |          7 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                   X                          X                           |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3|            |
                                           | 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Lymphoma Malignant Mixed|                                  X  X                                X   |          6 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                              X           X               |          2 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Lymphoma Malignant Histiocytic|                                              X           X               |          2 |
      Renal, Lymphoma Malignant Lymphocytic|       X                                                                  |          1 |
      Renal, Lymphoma Malignant Mixed      |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  +  M  M  M  M  M  +  M  M  M  M  M  +  +  M  M  M  +  M  M  M  +  M|  13        |
      Lymphoma Malignant Histiocytic       |                                              X           X               |          3 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
      Lymphoma Malignant Mixed             |                         X                 X                          X   |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                   X                          X           X               |          5 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          6 |
      Lymphoma Malignant Mixed             |                         X        X  X     X                          X   |          8 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +|  38        |
      Lymphoma Malignant Histiocytic       |                   X                                      X               |          2 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          3 |
      Lymphoma Malignant Mixed             |                         X                                                |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  M  +  +  M  M  M  M  M  +  M  +  +  M  M  +  +  M  +  +  M  +  +|  33        |
      Adenoacanthoma                       |                                                                          |          1 |
      Adenocarcinoma                       |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                         X|          4 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosarcoma, Metastatic, Skin       |                                                             X           X|          2 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3|            |
                                           | 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
      Meningioma Benign                    |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  M  +  +  M  +  +  +  +  +  M  +  +  I  +  +  +  +  +  +  +  +  +  +|  42        |
      Sciatic, Lymphoma Malignant Mixed    |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          2 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |    X           X                          X                              |          6 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                X                 X     X                    X            |          7 |
      Fibrosarcoma, Metastatic, Skin       |                                                             X            |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                   X                                      X               |          4 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          2 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                X                                                         |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                   X                                                      |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinum, Lymphoma Malignant Mixed|                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3|            |
                                           | 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |          X                 X     X                       X        X  X  X|         12 |
      Adenoma, Multiple                    |                                                                          |          1 |
      Carcinoma                            |             X                                                  X         |          2 |
      Bilateral, Adenoma                   |                                     X        X                           |          7 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                   X                          X           X               |          4 |
      Lymphoma Malignant Lymphocytic       |       X                                                                  |          5 |
      Lymphoma Malignant Mixed             |                         X           X     X                              |          5 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +           +        +     +     +     +  +     +     +  +  +  +  +     +|  26        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                   X     X                    X           X               |          6 |
      Lymphoma Malignant Lymphocytic       |       X  X                                X                              |          8 |
      Lymphoma Malignant Mixed             |                         X        X  X     X                          X   |          9 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|             
                                           | 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  A|             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                              X                          X|             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |                                                                X         |             
      Hepatocellular Adenoma, Multiple     |                            X                                         X   |             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor Benign               |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     | X                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                   X      |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  M  +  M  +  +  M  M  M  M  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|             
                                           | 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |       +              +     +     +        +     +  +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |       +        +  +  +           +        +     +  +     +        +     +|             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |             +                                                            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                      +   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +        +  +  +     +     +        +  +  +  +        +     +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                           +           +                  |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                                                                          |             
      Vertebral, Lymphoma Malignant        |                                                                          |             
          Histiocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                           X                              |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                           X                              |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                   X      |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                           X                              |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  M  M  M  +  +  +  M  M  M  +  M  +  M  +  M  +  M  M  M  +  M  +  M  M|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                             X     X      |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|             
                                           | 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |    X                                                                 X   |             
      Subcutaneous Tissue, Fibrosarcoma    | X  X           X  X              X     X                       X     X   |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                     X           X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                  X  X           X                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +                                                                        |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X                          X                                             |             
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                         X|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|             
                                           | 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                     X                                    |             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
                                            __________________________________________________________________________|             
   Ureter                                  | +  +  +  +     +  +  +     +  +  +     +  +  +  +  +  +  +     +         |             
                                            __________________________________________________________________________|             
   Urethra                                 | +  +     +  +  +  +        +  +        +  +           +     +            |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                             X     X      |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3|            |
                                           | 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  M  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
      Polyp Adenomatous                    |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                              X                           |          3 |
      Hepatocellular Carcinoma, Multiple   |          X                                            X     X            |          3 |
      Hepatocellular Adenoma               |                                  X           X                           |          3 |
      Hepatocellular Adenoma, Multiple     |    X  X  X                                                               |          5 |
      Lymphoma Malignant Histiocytic       |                         X                 X                             X|          4 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +  +  +     +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +   |  43        |
      Lymphoma Malignant Histiocytic       |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mast Cell Tumor Benign               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                         X                 X                              |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Capsule, Adenoma                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3|            |
                                           | 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Benign              |                                                                          |          1 |
      Bilateral, Pheochromocytoma Benign   |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  +  M  +  +  M  M  M  +  M  +  +  +  M  +  +  +  +  M  +  M|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Intermedia, Adenoma             |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                     M                                    |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |    +  +  +        +  +  +  +  +  +  +  +  +     +                 +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |    +  +     +     +  +  +  +     +  +     +        +        +            |  23        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                          +     +         |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                       +                                    |   3        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +  +  +        +  +  +  +  +  +  +  +  +        +  +        +  +   |  29        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                         +                                                |   3        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                                           X                              |          1 |
      Vertebral, Lymphoma Malignant        |                                                                          |            |
          Histiocytic                      |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                         X                 X                              |          2 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                           X                              |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3|            |
                                           | 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                         X                                                |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  +  +  M  M  M  M  +  M  M  +  M  +  +  +  +  M  M  M  M  M  +  +  M|  19        |
      Lymphoma Malignant Histiocytic       |                         X                 X                              |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                         X                 X           X                  |          5 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  M  M  +  M  +  +  M  M  +  +  M  +  M  +  +  +  M|  36        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibroma         |                                        X     X                           |          4 |
      Subcutaneous Tissue, Fibrosarcoma    |                X     X           X                          X  X         |         13 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                         X                 X                              |          2 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |          3 |
      Alveolar/Bronchiolar Carcinoma       |                               X                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3|            |
                                           | 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                              X                           |          2 |
      Lymphoma Malignant Histiocytic       |                         X                 X                              |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                   X                                                      |          1 |
      Carcinoma                            |                                                       X                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                         X                 X                              |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                X         |          2 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +     +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +     +|  39        |
                                            __________________________________________________________________________|____________|
   Urethra                                 | +        +  +  +  +  +  +  +  +     +  +     +     +     +  +  +  +     +|  30        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                         X                 X           X                 X|          6 |
      Lymphoma Malignant Lymphocytic       |                                                                X         |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|             
                                           | 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +  +        +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       A  M  +  +        +  A     +  +        +     A        A  A         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +  +        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +  +        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  M        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       M  M  +  M        A  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +  +        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +  +        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       A  +  +  +        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +  +        +  +     +  +        +     A        +  A         |             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                       X  X               |             
      Hepatocellular Carcinoma             |                               X                 X                       X|             
      Hepatocellular Carcinoma, Multiple   | X  X                                      X                    X         |             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     |                      X                                                   |             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +  +        +  +     +  +        +              +  +         |             
      Adenocarcinoma, Metastatic, Stomach  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +        +  +     +  +        +     A        +  +         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +  +        +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Tongue                                  |                            M                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +  +  +  +        +  +     +  +        +     +        +  +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +  +  +        +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Adenocarcinoma, Metastatic, Stomach  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +  +        +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +  +        +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +  +        +  +     +  M        +     +        +  +         |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  +        +  +     +  +        +     A        +  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|             
                                           | 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  M  +  M        M  M     +  +        +     I        +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  +        +  +     M  M        +     M        +  +         |             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |       +  +  +           +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |       +  +  +  +        +  +     +           +     +        +  +         |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +  +  +        +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Penis                                   |       +                 +                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +  +        +  +     +                                       |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +  +        +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  M  +  M  +  +  +  +     +  M        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Adenocarcinoma, Metastatic, Stomach  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Femoral, Adenocarcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +     +|             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed |                                                                   X      |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                     X                                    |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       M  M  M  M  +     M  A  +  M  +  +     M     M  +  +  M  M  +     +|             
      Lymphoma Malignant Histiocytic       |                               X     X                                    |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Mediastinal, Adenocarcinoma,         |                                                                          |             
          Metastatic, Stomach              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +  +        +  +  +  +  +  +     +     +        +  +  +      |             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       M  +  +  +        +  +     +  +        +     +        +  M         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|             
                                           | 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       M  M  M  M        M  M     M  M        M     M        M  M         |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +        +  +     +  +  +     +     +        +  +  +      |             
      Adenocarcinoma, Metastatic, Stomach  |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                        X                                 |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Meningioma Benign                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  M  M  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +  +  +  +        +  +     +  +        +     +        +  +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Stomach  |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                               X     X                                    |             
      Alveolar/Bronchiolar Carcinoma       |                   X                                   X              X   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |    X                                                                     |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X                                                                       X|             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +  +        +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +        +  +     +  +        +     +        +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                 X                 X        X      |             
      Bilateral, Adenoma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +        +  +     +  +        +     +        +  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|             
                                           | 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma, Metastatic, Stomach  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Ureter                                  |       +     +  +           +     +  +        +              +            |             
                                            __________________________________________________________________________|             
   Urethra                                 |       +  +  +  +        +           +                       +            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +  +        +  +     +  +        +     M        +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                               X     X                                    |             
      Lymphoma Malignant Mixed             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3|            |
                                           | 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +           +  +                    +        +        +     +|  20        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          M  +           +  A                    +        +        +     +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  +           +  A                    +        +        +     +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          A  A           +  M                    +        +        +     +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +           +  A                    +        +        +     +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          A  +           +  A                    +        +        M     +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          A  +           +  A        +           +        +        +     +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          A  +           +  A                    +        +        +     +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          A  A           +  A                    +        +        +     +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          A  M           +  A        +           +        +        +     +|  16        |
      Adenocarcinoma                       |                                     X                                    |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Hepatocellular Carcinoma             | X                                X  X  X                                 |          7 |
      Hepatocellular Carcinoma, Multiple   |                                              X  X                        |          6 |
      Hepatocellular Adenoma               |                               X           X                    X         |          3 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +           +  +                    +        +        +     +|  18        |
      Adenocarcinoma, Metastatic, Stomach  |             X                                                            |          1 |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +           +  +                 +  +        +        +     +|  21        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +           +  +                    +        +        +     +|  20        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          A  +           +  +                    +        +     +  +     +|  20        |
      Adenocarcinoma                       |             X                                                            |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +  +           +  +                    +        +        +     +|  20        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +  +           +                       +        +        +     +|  19        |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +           +  +                    +        +        +     +|  20        |
      Adenocarcinoma, Metastatic, Stomach  |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3|            |
                                           | 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +  +           +  +                    +        +        +     +|  21        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +     +  +           +  +                    +        +        +     +|  21        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +     +  +           +  +                    +        +        +     +|  20        |
      Pheochromocytoma Benign              |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  +           +  +                    +        +        +     +|  19        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  M           +  M                    M        +        +     +|  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          I  +           +  M                    +        M        +  +  M|  14        |
      Pars Distalis, Adenoma               |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +           +  +                    +        +        +     +|  20        |
      Follicular Cell, Adenoma             |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |          +  +              +                    +        +        +     +|  18        |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |          +  +              +                                      +     +|  16        |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +  +           +  +                    +        +        +     +|  20        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                          +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Prostate                                |          +  +           +  +                    +        +        +     +|  20        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +              +                    +        +        +  +  +|  18        |
                                            __________________________________________________________________________|____________|
   Testes                                  |          +  +           +  +                    +        +        +     +|  20        |
      Adenocarcinoma, Metastatic, Stomach  |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                         +                                +               |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +           +  +                    +        +        +     +|  20        |
      Femoral, Adenocarcinoma, Metastatic, |                                                                          |            |
           Stomach                         |             X                                                            |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +     +     +  +  +  +     +        +        +        +     +|  32        |
      Lumbar, Lymphoma Malignant Mixed     |                                        X                                 |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                   X      |          1 |
      Mandibular, Lymphoma Malignant Mixed |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                   X      |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3|            |
                                           | 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Lymphoma Malignant Mixed      |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          M  +     +     +  M  +  +     +        M        +        +     +|  17        |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          3 |
      Lymphoma Malignant Mixed             |                               X        X                                 |          3 |
      Mediastinal, Adenocarcinoma,         |                                                                          |            |
          Metastatic, Stomach              |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +           +  +        +  +        +        +        +     +|  26        |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          2 |
      Lymphoma Malignant Mixed             |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          M  M           M  +                    +        +        M     M|  13        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M  M           M  M                    M        M        M     M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +     +  +  +        +  +  +  +  +     +        +  +  +|  33        |
      Adenocarcinoma, Metastatic, Stomach  |             X                                                            |          1 |
      Subcutaneous Tissue, Fibrosarcoma    | X  X  X        X  X     X              X  X  X  X  X     X              X|         14 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +     +  +  +  +  +  +  +           +  +  +  +        +     +|  34        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +  +  +  +     +  +           +  +     +        +        +     +|  24        |
      Fibrosarcoma, Metastatic, Skin       |                X  X     X              X  X              X              X|          7 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +           +  +                    +        +        +     +|  20        |
      Meningioma Benign                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|  39        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |          +  +           +  +                    +        +        +     +|  20        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Stomach  |             X                                                            |          1 |
      Alveolar/Bronchiolar Adenoma         |             X                                X        X                 X|          6 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Skin       |                X                                                         |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3|            |
                                           | 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Liver                           |                                                                          |          2 |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +           +  +                    +        +        +     +|  20        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  +           +  +                    +        +        +     +|  20        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +        +                              |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |          X           X              X  X  X  X        X  X     X         |         13 |
      Bilateral, Adenoma                   |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +           +  +           +     +  +        +        +     +|  22        |
      Adenocarcinoma, Metastatic, Stomach  |             X                                                            |          1 |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |          +  +           +                       +        +        +     +|  15        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                            +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +  +           +  +                    +        +        +     +|  21        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                   X      |          3 |
      Lymphoma Malignant Mixed             |                               X        X                                 |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|             
                             DAY ON TEST   | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|             
                                           | 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  A  +  A  +  +  +  A  M  A  +  +  +  A  +  A  +  +  +  +  A  A  +  A|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  A  +  +  +  A     +  +  +  +  A  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A     +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A     +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A     +  +  +  +  A  +  +  +  +  +  +  +  A     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  A  +  +  +  A     +  +  +  +  A  +  +  +  +  +  +  +  A     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  A     +  +  +  +  A  +  +  +  +  +  +  +  A     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Hepatocellular Carcinoma             |                               X           X     X        X               |             
      Hepatocellular Carcinoma, Multiple   |                            X                                             |             
      Hepatocellular Adenoma               | X  X        X        X           X     X                 X               |             
      Hepatocellular Adenoma, Multiple     |          X                                                               |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  A     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +     +  +     +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|             
                             DAY ON TEST   | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|             
                                           | 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Alveolar/Bronchiolar        |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                        X                                 |             
      Bilateral, Pheochromocytoma Benign   |          X                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  A  +  +  M  M  M  +  +  M  M  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                     X              X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |    +  +  +  +  +        +     +        +  +  +  +              +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                         +  +                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +           +  +     +  +  +  +  +  +        +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Vertebral, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|             
                             DAY ON TEST   | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|             
                                           | 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Axillary, Fibrosarcoma, Metastatic,  |                                                                          |             
           Skin                            |                                                                   X      |             
      Bronchial, Alveolar/Bronchiolar      |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                             X            |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |       X                                                                  |             
      Mandibular, Lymphoma Malignant Mixed |                                        X                                 |             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                 X                        |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |       X                                   X                              |             
      Mediastinal, Lymphoma Malignant Mixed|                                        X                                 |             
      Mediastinal, Mandibular,             |                                                                          |             
          Alveolar/Bronchiolar Carcinoma,  |                                                                          |             
           Metastatic, Lung                |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  M  +  +  M  +  M  +  M  +  M  +  M  +  M  M  M  M  +  M  M  +  +  M  M|             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |       X                                   X                              |             
      Lymphoma Malignant                   |                         X                                                |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  A  M  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                   X                              |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Subcutaneous Tissue, Fibroma         |    X                                                           X         |             
      Subcutaneous Tissue, Fibrosarcoma    |    X           X                    X                       X  X  X  X   |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|             
                             DAY ON TEST   | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|             
                                           | 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                X                                            X            |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
      Diaphragm, Alveolar/Bronchiolar      |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X  X     X                          X              X                  |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                             X            |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
      Lymphoma Malignant                   |                         X                                                |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|             
                             DAY ON TEST   | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|             
                                           | 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |    X  X  X                          X  X  X  X     X     X        X  X  X|             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |       X                                   X                              |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Ureter                                  | +  +     +  +  +  +  +  +  +  +     +  +  +     +        +  +  +        +|             
                                            __________________________________________________________________________|             
   Urethra                                 |    +  +     +     +  +     +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                         X                                                |             
      Lymphoma Malignant Histiocytic       |                                     X           X                        |             
      Lymphoma Malignant Lymphocytic       |       X                                   X                              |             
      Lymphoma Malignant Mixed             |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3|            |
                                           | 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  A  +  +  +  +  A  A  A  +  +  +  +  +  M  +  +  +  +|  33        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  +  +  A  +  A  +  +  +  +  +  M  A  +  +     +  +  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +|  40        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  A  +  A  +  +  +  M  +  +  A  +  +     +  +  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |       X                                                                  |          1 |
      Hepatocellular Carcinoma             |          X                    X  X           X              X           X|         10 |
      Hepatocellular Carcinoma, Multiple   |                                                          X               |          2 |
      Hepatocellular Adenoma               |          X        X     X     X  X                    X                  |         13 |
      Hepatocellular Adenoma, Multiple     |                            X                 X  X  X                 X   |          6 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                            X              X                              |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                            X              X                              |          3 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Squamous Cell Papilloma              |                                                 X  X                     |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3|            |
                                           | 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +  +  +  +        +  +  +  +  +  +           +        +  +     +  +|  34        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |    X  X                                                                  |          2 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Capsule, Alveolar/Bronchiolar        |                                                                          |            |
          Carcinoma, Metastatic, Lung      |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              |                                              X                           |          2 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         | +  +     +  +  +     +  +  +  +           +  +  +     +        +         |  28        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   | +              +                                   +           +         |   4        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +           +                    +        +               |   6        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +     +  +  +  +  +  +  +     +     +     +  +  +  +     +  +  +   |  36        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3|            |
                                           | 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Metastatic, Lung                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                            X              X                              |          2 |
      Vertebral, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Fibrosarcoma, Metastatic,  |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Bronchial, Alveolar/Bronchiolar      |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mandibular, Lymphoma Malignant Mixed |                                                                         X|          2 |
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |    X                                                                     |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Mediastinal, Mandibular,             |                                                                          |            |
          Alveolar/Bronchiolar Carcinoma,  |                                                                          |            |
           Metastatic, Lung                |       X                                                                  |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  M  M  +  M  M  M  M  M  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +|  24        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
      Lymphoma Malignant Mixed             |                                                                         X|          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                            X     X                                       |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                         X|          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|  39        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3|            |
                                           | 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Metastatic, Lung                 |    X  X     X                                                            |          3 |
      Lymphoma Malignant Lymphocytic       |                            X              X                              |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M|   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basal Cell Adenoma                   |                                                 X                        |          1 |
      Subcutaneous Tissue, Fibroma         |                                                 X                        |          3 |
      Subcutaneous Tissue, Fibrosarcoma    |                X              X                       X                  |         10 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |    X                                                                     |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                                   X      |          3 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
      Diaphragm, Alveolar/Bronchiolar      |                                                                          |            |
          Carcinoma, Metastatic, Lung      |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |       X                                                                  |          1 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                    X                     |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |    X                 X     X                    X     X                  |         10 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3|            |
                                           | 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Carcinoma       |    X  X     X     X  X              X                    X        X      |          9 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                  X                                       |          1 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                    X                     |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                                   X      |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                             X            |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |       X     X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +              +                          +           +         |   4        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |    X  X  X  X     X  X     X  X  X  X        X     X     X     X        X|         27 |
      Carcinoma                            |                                                    X                 X   |          2 |
      Bilateral, Adenoma                   |                X        X                                                |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |    X  X                                                                  |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                            X              X                              |          4 |
      Lymphoma Malignant Mixed             |                                                                         X|          2 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |    +     +  +  +        +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Urethra                                 | +     +  +        +     +  +  +  +  +  +     +     +  +  +     +        +|  35        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                            X                                             |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05024-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:53:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3|            |
                                           | 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                            X              X                              |          4 |
      Lymphoma Malignant Mixed             |                                                                         X|          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
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