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TDMS Study 05024-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                        N-METHYLOLACRYLAMIDE


NTP Experiment-Test: 05024-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 04:40:25




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  924-42-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05024-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               5            9           10                                                  
    Moribund                                           3            6            6                                                  
    Accident                                           1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           35           33                                                  
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    50           50           49                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (4)          (39)                                                
   Intestine Large, Cecum                             (46)         (5)          (42)                                                
      Leiomyoma                                                     1 (20%)                                                         
   Intestine Large, Rectum                            (46)         (6)          (43)                                                
   Intestine Small, Duodenum                          (44)         (5)          (41)                                                
   Intestine Small, Ileum                             (44)         (4)          (43)                                                
   Intestine Small, Jejunum                           (45)         (4)          (42)                                                
   Liver                                              (50)         (50)         (49)                                                
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
      Hemangioma, Multiple                             1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Skin                             1 (2%)                                                          
      Hepatocellular Carcinoma                         3 (6%)       3 (6%)       2 (4%)                                             
      Hepatocellular Adenoma                           2 (4%)       3 (6%)      15 (31%)                                            
      Hepatocellular Adenoma, Multiple                 1 (2%)       1 (2%)       2 (4%)                                             
   Mesentery                                          (48)         (6)          (47)                                                
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
   Pancreas                                           (50)         (6)          (47)                                                
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
   Salivary Glands                                    (50)         (7)          (47)                                                
   Stomach, Forestomach                               (46)         (6)          (44)                                                
      Squamous Cell Papilloma                                                    2 (5%)                                             
   Tongue                                                                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05024-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (6)          (49)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (17%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (6)          (47)                                                
      Capsule, Carcinoma                                                         1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (7)          (48)                                                
      Pheochromocytoma Benign                                       1 (14%)                                                         
   Islets, Pancreatic                                 (50)         (6)          (47)                                                
   Pituitary Gland                                    (49)         (14)         (43)                                                
      Pars Distalis, Adenoma                          12 (24%)      5 (36%)      4 (9%)                                             
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
      Pars Intermedia, Carcinoma                       1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (48)         (6)          (48)                                                
      Bilateral, Follicular Cell, Adenoma, Multiple    1 (2%)                                                                       
      Follicular Cell, Adenoma                         3 (6%)                    3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                  (1)                                                              
      Adenocarcinoma                                                1 (100%)                                                        
   Ovary                                              (50)         (45)         (47)                                                
      Granulosa Cell Tumor Benign                                   5 (11%)      5 (11%)                                            
   Uterus                                             (50)         (35)         (49)                                                
      Hemangioma                                                    1 (3%)                                                          
      Hemangiosarcoma                                  1 (2%)       1 (3%)                                                          
      Leiomyoma                                                     1 (3%)                                                          
      Polyp Stromal                                    2 (4%)       1 (3%)                                                          
   Vagina                                             (1)          (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05024-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (6)          (48)                                                
      Femoral, Hemangiosarcoma                                                   1 (2%)                                             
      Vertebral, Hemangiosarcoma                                                 1 (2%)                                             
   Lymph Node                                         (50)         (13)         (46)                                                
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (8%)                                                          
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (11)         (7)          (13)                                                
   Spleen                                             (50)         (19)         (48)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Metastatic, Skin                             1 (5%)                                                          
   Thymus                                             (48)         (4)          (38)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (29)         (48)         (33)                                                
      Adenoacanthoma                                                1 (2%)       1 (3%)                                             
      Adenocarcinoma                                   1 (3%)                    1 (3%)                                             
      Adenoma                                          2 (7%)       4 (8%)                                                          
      Fibroadenoma                                     1 (3%)                                                                       
   Skin                                               (50)         (14)         (48)                                                
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       2 (14%)      4 (8%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple                                1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                          3 (21%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (50)         (6)          (48)                                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)       1 (17%)      2 (4%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (7)          (48)                                                
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
      Meningioma Benign                                                          1 (2%)                                             
   Peripheral Nerve                                   (47)         (43)         (42)                                                
   Spinal Cord                                        (50)         (6)          (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05024-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)                                                
      Adenoacanthoma, Metastatic, Mammary Gland                     1 (2%)                                                          
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     4 (8%)       3 (6%)       6 (12%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       4 (8%)       7 (14%)                                            
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Basosquamous Tumor Malignant                                  1 (2%)                                                          
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hemangiosarcoma, Metastatic, Skin                             1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       1 (2%)       1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
      Mediastinum, Hemangiosarcoma                     1 (2%)                                                                       
   Nose                                               (50)         (6)          (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (47)         (45)         (48)                                                
      Adenoma                                          5 (11%)      6 (13%)     12 (25%)                                            
      Adenoma, Multiple                                             1 (2%)       1 (2%)                                             
      Carcinoma                                                     3 (7%)       2 (4%)                                             
      Bilateral, Adenoma                                            1 (2%)       7 (15%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (11)         (48)                                                
   Urinary Bladder                                    (43)         (6)          (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(49)                                                
      Lymphoma Malignant                                            1 (2%)                                                          
      Lymphoma Malignant Histiocytic                   5 (10%)      2 (4%)       6 (12%)                                            
      Lymphoma Malignant Lymphocytic                   7 (14%)      7 (14%)      8 (16%)                                            
      Lymphoma Malignant Mixed                         4 (8%)       1 (2%)       9 (18%)                                            
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05024-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            33          41          47                                                   
     Total Primary Neoplasms                           66          67         108                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 24          24          39                                                   
     Total Benign Neoplasms                            36          35          61                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          26          33                                                   
     Total Malignant Neoplasms                         30          32          47                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           7           5                                                   
     Total Metastatic Neoplasm                          5           9           9                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05024-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          12           14           10                                                  
    Dead                                               8           16           19                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           20           20                                                  
    Moribund                                                                     1                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (20)         (48)                                                
   Gallbladder                                        (44)         (12)         (33)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (3%)                                             
   Intestine Small, Duodenum                          (45)         (16)         (40)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (3%)                                             
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (45)         (16)         (40)                                                
      Adenocarcinoma                                                1 (6%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Hemangiosarcoma                                               2 (4%)                                                          
      Hepatocellular Carcinoma                         3 (6%)       7 (14%)     10 (20%)                                            
      Hepatocellular Carcinoma, Multiple               3 (6%)       6 (12%)      2 (4%)                                             
      Hepatocellular Adenoma                           3 (6%)       3 (6%)      13 (26%)                                            
      Hepatocellular Adenoma, Multiple                 5 (10%)      1 (2%)       6 (12%)                                            
   Mesentery                                          (43)         (18)         (49)                                                
      Adenocarcinoma, Metastatic, Stomach                           1 (6%)                                                          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
   Pancreas                                           (49)         (21)         (47)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
   Salivary Glands                                    (49)         (20)         (50)                                                
   Stomach, Forestomach                               (50)         (49)         (48)                                                
      Mast Cell Tumor Benign                           1 (2%)                                                                       
      Squamous Cell Papilloma                                       1 (2%)       2 (4%)                                             
   Stomach, Glandular                                 (50)         (20)         (45)                                                
      Adenocarcinoma                                                1 (5%)                                                          
                                                             Page   7                                                               
NTP Experiment-Test: 05024-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (20)         (50)                                                
      Adenocarcinoma, Metastatic, Stomach                           1 (5%)                                                          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (21)         (48)                                                
      Capsule, Adenoma                                 1 (2%)                                                                       
      Capsule, Alveolar/Bronchiolar Carcinoma,                                                                                      
           Metastatic, Lung                                                      1 (2%)                                             
   Adrenal Gland, Medulla                             (48)         (20)         (50)                                                
      Pheochromocytoma Benign                          1 (2%)       1 (5%)       2 (4%)                                             
      Bilateral, Pheochromocytoma Benign               1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (19)         (47)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
   Pituitary Gland                                    (48)         (14)         (42)                                                
      Pars Distalis, Adenoma                                        1 (7%)                                                          
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (20)         (49)                                                
      Follicular Cell, Adenoma                                      1 (5%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ductus Deferens                                    (23)         (16)         (28)                                                
   Epididymis                                         (50)         (20)         (50)                                                
   Prostate                                           (49)         (20)         (50)                                                
   Seminal Vesicle                                    (29)         (18)         (36)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (3%)                                             
   Testes                                             (50)         (20)         (50)                                                
      Adenocarcinoma, Metastatic, Stomach                           1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05024-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (3)          (2)                                                              
   Bone Marrow                                        (50)         (20)         (50)                                                
      Femoral, Adenocarcinoma, Metastatic, Stomach                  1 (5%)                                                          
   Lymph Node                                         (49)         (32)         (50)                                                
      Axillary, Fibrosarcoma, Metastatic, Skin                                   1 (2%)                                             
      Bronchial, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                                      1 (2%)                                             
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
      Mediastinal, Mandibular,                                                                                                      
          Alveolar/Bronchiolar Carcinoma,                                                                                           
          Metastatic, Lung                                                       1 (2%)                                             
   Lymph Node, Mesenteric                             (19)         (17)         (24)                                                
      Mediastinal, Adenocarcinoma, Metastatic,                                                                                      
           Stomach                                                  1 (6%)                                                          
   Spleen                                             (50)         (26)         (50)                                                
      Hemangiosarcoma                                                            2 (4%)                                             
   Thymus                                             (36)         (13)         (39)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  3 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (33)         (50)                                                
      Adenocarcinoma, Metastatic, Stomach                           1 (3%)                                                          
      Basal Cell Adenoma                                                         1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     4 (8%)                    3 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma               13 (26%)     14 (42%)     10 (20%)                                            
      Subcutaneous Tissue, Fibrosarcoma, Multiple      2 (4%)       1 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (34)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
   Skeletal Muscle                                    (50)         (24)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   3 (6%)       7 (29%)      3 (6%)                                             
      Diaphragm, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05024-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (20)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Meningioma Benign                                             1 (5%)                                                          
   Spinal Cord                                        (48)         (20)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)                                                
      Adenocarcinoma, Metastatic, Stomach                           1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                     3 (6%)       6 (12%)     10 (20%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       3 (6%)       9 (18%)                                            
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       2 (4%)       1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      2 (4%)                                             
   Nose                                               (50)         (20)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (48)         (49)         (50)                                                
      Adenoma                                          1 (2%)      13 (27%)     27 (54%)                                            
      Carcinoma                                        1 (2%)                    2 (4%)                                             
      Bilateral, Adenoma                                            1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (22)         (50)                                                
      Adenocarcinoma, Metastatic, Stomach                           1 (5%)                                                          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  2 (4%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
   Urethra                                            (30)         (8)          (35)                                                
   Urinary Bladder                                    (49)         (21)         (49)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
                                                             Page  10                                                               
NTP Experiment-Test: 05024-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant                                                         1 (2%)                                             
      Lymphoma Malignant Histiocytic                   6 (12%)      3 (6%)       2 (4%)                                             
      Lymphoma Malignant Lymphocytic                   2 (4%)                    4 (8%)                                             
      Lymphoma Malignant Mixed                                      3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05024-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 04:40:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      25 MG/KG     50 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          39          47                                                   
     Total Primary Neoplasms                           54          71         116                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 16          22          38                                                   
     Total Benign Neoplasms                            22          29          70                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          33          35                                                   
     Total Malignant Neoplasms                         32          42          46                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5          10           9                                                   
     Total Metastatic Neoplasm                          6          18          33                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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