National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3736

TDMS Study 05024-02 Pathology Tables

NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97
Route: GAVAGE                                                                                                     Time: 13:02:46




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  924-42-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                                               |             
      Inflammation, Chronic Active         | 1                    4                                                   |             
      Leukocytosis                         |                X                                                         |             
      Vacuolization Cytoplasmic            |          2                                                               |             
      Artery, Necrosis, Fibrinoid          |                      4                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               3                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +              +  +  +  +        +  +  +  +        +  +        +     +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |             2                 2                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  M  +  M  M  M  +  M  +  +  M  M  M  +  +  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 2  3     2  3     2  2  2  2        2           2     2  2  2  2  2     2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Inflammation, Chronic Active         | 1                                                                        |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                     2     2           3                 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                X                       X                                X|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                        2                                 |             
                                            __________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  +     +  +     +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                      X                                                   |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 2  2  3  3     3  2  2  3  4  4  2  3  2     2  3  3  4  4  2  1  2  4  2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Reticulum Cell |                                              2                           |             
      Femoral, Myelofibrosis               |                                                             2        2   |             
      Vertebral, Myelofibrosis             |       2  2  2  2  2     2  2  2     2  1     2  2  2        2        2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  M  M  +  +  M  M  M  +  A  M  M  M  M  M  M  M  +  M  M  M  M  M|             
      Hematopoietic Cell Proliferation     |                               2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X                                                            |             
      Hematopoietic Cell Proliferation     |                4                 3                             4     3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  M  +  M  +  +  +  +  +  M  +  +  M  M  +  +  M  M  M  M  M|             
      Hyperplasia, Cystic                  |             2           1  1              2           1                  |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
      Inflammation, Chronic Active         |                      4                                                   |             
      Artery, Necrosis, Fibrinoid          |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      White Matter, Degeneration           | 2                                                  1                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2        2     2     1                       2  2     2                  |             
      Alveolar Epithelium, Hyperplasia     |                      2                          2     2                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    2                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                                   2      |             
      Nephropathy, Chronic                 |    4              1     1                                                |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                              +  +              +  +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M     +  +  +     +  +|             
      Inflammation, Chronic Active         |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|            |
                                           | 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Leukocytosis                         |                                                                          |      1     |
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Inflammation, Chronic Active         | 3                                         4                              |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                        3  3     4                        |      3  3.3|
      Duct, Ectasia                        |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +     +  +  +  A|  46        |
      Acanthosis                           |       3                    3                                             |      3  3.0|
      Hyperkeratosis                       |                            4                                             |      1  4.0|
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  A|  47        |
      Inflammation, Chronic Active         |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |                                                                2         |      1  2.0|
      Inflammation, Chronic Active         | 2                                                              2         |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +        +     +  +  +  +  +  +                 +        +     +  +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   5                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|            |
                                           | 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      2                                                   |      1  2.0|
      Hypertrophy                          |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            2                          2           2      |      5  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  M  M  +  +  M  +  M  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Pars Distalis, Cyst                  |                                              X                           |      1     |
      Pars Distalis, Hyperplasia           |             2                 2        2  1        2  2                  |     22  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                             2            |      2  1.5|
      C-Cell, Hyperplasia                  |                                                          2               |      1  2.0|
      Follicle, Cyst                       |                      X                                                   |      1     |
      Follicular Cell, Hyperplasia         |                2  2        2                          2     2            |      9  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                  3                    4        3         |      3  3.3|
      Cyst                                 |       X     X  X                          X     X     X           X      |     10     |
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |    +  +  +  +  +        +  +     +  +  +     +     +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 2                                                                        |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 1  3  2  3  3  2  2  2  2  4  2  2  3  2  2  2  2  3  4  4  3  3  2  3   |     47  2.6|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia, Reticulum Cell |                                                                          |      1  2.0|
      Femoral, Myelofibrosis               |                         1                                                |      3  1.7|
      Vertebral, Myelofibrosis             |    2     2  2  3  1     2           2  1  2  2        2     2  1         |     29  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|            |
                                           | 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumbar, Hyperplasia, Lymphoid        | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  +  M  M  M  M  M  M  M  +  +  M  M  +  M  M  M  M  M  M  M  +  M  M|  11        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     | 4                             4           3     2  2  4  2     3  3  3  2|     15  3.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                       X                  |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  M  +  M  M  +  +  +|  29        |
      Hyperplasia, Cystic                  | 1     1  1  1  1  2     1  2        1     2  1  2                 1  1  2|     20  1.4|
      Hyperplasia                          |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute                    |                                                                         4|      1  4.0|
      Inflammation, Chronic Active         | 3                                                                        |      2  3.5|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      White Matter, Degeneration           |                                                 2     2        2         |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |       1                       2                          2  2     2      |     12  1.8|
      Alveolar Epithelium, Hyperplasia     |       1                       2                          2  2     2      |      8  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|            |
                                           | 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                       1                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Osseous                  |                         2                                                |      2  2.0|
      Nephropathy, Chronic                 |    1     1        1  1  1              1  1                              |     10  1.3|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                   +                 +  +  M     +  +           +         |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A|  43        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|             
                                           | 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +                          +               |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                               A                          +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +                       +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               M                       +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +                          +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +                          +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +                          +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +                          +               |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               M                          +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               M                          +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Atypia Cellular                      |                                                                          |             
      Degeneration, Cystic                 |                                                                      2   |             
      Hematopoietic Cell Proliferation     |             2                          2                                 |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                      2   |             
      Leukocytosis                         |       X                                                              X   |             
      Necrosis, Coagulative                |                            2                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                          +               |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +                          +               |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                            +  +                          +               |             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +                          +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +                          +               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               A                          +               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                          +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +                          +               |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +                          +               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +                          +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +                          +               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +                          +               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +                          +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               M                          +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +     +              +  +                       +           +  +|             
      Pars Distalis, Hyperplasia           |          2                                                              2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +                          +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|             
                                           | 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                        +                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  I  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3  3  3  3     3  2     3        3  3     3  3  3  3     3  3  3  3  3|             
      Cyst                                 | X                 X                    X        X           X            |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                               +                          +               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +  +  +  +  +     +  +  +  +     +  +  +        +     +|             
      Dilatation                           |                                           4                              |             
      Hemorrhage                           |    2                       2                                             |             
      Artery, Hyperplasia, Cystic,         |                                                                          |             
          Glandular                        |                      2                                                   |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 2  3  2        4  3     4  2        2  2  1  2     3  2  2        2     2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Neutrophilia                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +                          +               |             
      Femoral, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +              +  +                          +  +            |             
      Mandibular, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +              +  +                          M               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |             3                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +  +  +     +     +  A                 +        +  +  +  +      |             
      Hematopoietic Cell Proliferation     |          3  2  3     3                                   3               |             
      Hyperplasia, Lymphoid                |             3                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               M                          M               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1        2  3  2  1  1  1  1     2  2  1  1  1  1  1  1  2  1  1  2  1  1|             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +  +     +     +  +                          +           +   |             
      Abscess                              |                                                                          |             
      Alopecia                             |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|             
                                           | 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                               +                          +               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                       +                          +               |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  I  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Sciatic, Degeneration                |          2           2  2                                                |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                               +                          +               |             
      White Matter, Degeneration           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                          3               |             
      Inflammation, Chronic                |       2              3  2        2     2  1     2     2  2  2  2  2      |             
      Alveolar Epithelium, Hyperplasia     |       2              3  2        2     2        2     2     2  2  2  2   |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +                          +               |             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +                          +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +              +  +                          +  +            |             
      Amyloid Deposition                   |                                                                          |             
      Atrophy                              |             4                                                            |             
      Inflammation                         |             4                                                            |             
      Nephropathy, Chronic                 |             2                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +                          +               |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3|            |
                                           | 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                             A     +                    +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                             +     +                    +               |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                             A     +                    +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                             A     +                    +               |   5        |
      Inflammation, Chronic Active         | 4                                                                        |      1  4.0|
      Ulcer                                | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                             A     +                    +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                             A     +                    +               |   4        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   | 4                                                                        |      1  4.0|
      Atypia Cellular                      |    X                                                              X      |      2     |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 3                    2                                                   |      4  2.3|
      Infiltration Cellular, Lymphocyte    |    3                                                                     |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Leukocytosis                         |                                                                          |      2     |
      Necrosis, Coagulative                |                   3              1                                   2   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                             +     +                    +               |   6        |
      Acinus, Atrophy                      |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                             +     +                    +               |   7        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                             +     +                    +               |   5        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +                             +     +                    +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                             +     +                    +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                 +           +     +                    +               |   7        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                             +     +                    +               |   6        |
      Hematopoietic Cell Proliferation     | 3                                   2                                    |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                 +           +     +                    +               |   7        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3|            |
                                           | 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                             +     +                    +               |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                    +     +  +     +              +     +               |  14        |
      Pars Distalis, Hyperplasia           | 2                                   2                                    |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                             +     +                    +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  I  M  +|  45        |
      Atrophy                              | 3  3  3  3  3  3  3  3  3  3  4  3  4  3  3  3  3     3     3           3|     39  3.0|
      Cyst                                 |    X        X                             X                    X         |      9     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +  +  +     +           +  +     +  +  +  +      |  35        |
      Dilatation                           |                                                                   4      |      2  4.0|
      Hemorrhage                           |    2        3                                                  2         |      5  2.2|
      Artery, Hyperplasia, Cystic,         |                                                                          |            |
          Glandular                        |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 2  2  2  2  3     3  2  3           2           2  4     2  3  3  3      |     31  2.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                               +              +                           |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +                                   +                                    |   2        |
      Neutrophilia                         | X                                   X                                    |      2     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                             +     +                    +               |   6        |
      Femoral, Hyperplasia                 | 4                                   4                                    |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                          +  +  +  +        +           +           +   |  13        |
      Mandibular, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    | 3                                   2                                    |      2  2.5|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                             M  +  M        +           M           +   |   7        |
      Hematopoietic Cell Proliferation     | 3                                                                        |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                    +        +  +  +        +           +           +  +|  19        |
      Hematopoietic Cell Proliferation     | 4                             3     3        3           3               |     10  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3|            |
                                           | 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                          +  M     +                    +           +   |   4        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|  48        |
      Hyperplasia, Cystic                  | 2  1  1  1  1  1     1  1  1  1     1  1  1  2  1        1     2        1|     40  1.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                             +  +  +                    +        +      |  14        |
      Abscess                              | 4                                                                        |      1  4.0|
      Alopecia                             | X                                                                        |      1     |
      Foreign Body                         | 4                                                                        |      1  4.0|
      Inflammation, Chronic Active         | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                             +     +                    +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                             +     +                    +               |   7        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  M|  43        |
      Sciatic, Degeneration                |                                           2                              |      4  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                             +     +                    +               |   6        |
      White Matter, Degeneration           |                                     1                                    |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute                    |                                                                          |      1  3.0|
      Inflammation, Chronic                | 1  2     2  2     2  2  2  2        2  2  2     2  2  2              2  2|     28  2.0|
      Alveolar Epithelium, Hyperplasia     | 1  2     2  2     2  2  2  2                 2  2  2  2     2        2  2|     26  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                             +     +                    +               |   6        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                             +     +                    +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                                     2                       2            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                 +           +  +  +                    +               |  11        |
      Amyloid Deposition                   | 3                                                                        |      1  3.0|
      Atrophy                              |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3|            |
                                           | 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                                                                          |      1  4.0|
      Nephropathy, Chronic                 | 3                                   1                                    |      3  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                             M     +        +           +               |   6        |
      Hemorrhage                           |                                              3                           |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|             
                                           | 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  A  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     A  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     A  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     A  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     A  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     A  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     A  +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A|             
      Necrosis, Coagulative                |                      4                                                   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Necrosis, Coagulative                |       3                                                                  |             
      Pigmentation, Hematoidin             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            |          2                                                               |             
      Bile Duct, Cyst                      |                               X                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +        +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                4                                                         |             
      Necrosis                             |    4                                                                     |             
      Thrombosis                           |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 4                                                                        |             
      Acinus, Atrophy                      | 3                                                  2                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Acanthosis                           |                                                       3           2  3   |             
      Hyperkeratosis                       |                                                                   2      |             
      Inflammation, Chronic Active         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                              +                           |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                                     2  2                 3               |             
      Foreign Body                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|             
                                           | 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +        +  +     +  +        +  +     +     +  +     +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                                  2                                2      |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Corticomedullary Junction,           |                                                                          |             
          Degeneration, Fatty              |    2                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cyst                                 |                                                          X               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  A  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  +  M     +  +  M  M  +  +  +  +  M  M  +  +  M  M  +  +  M  M|             
      Cyst                                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +     M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Hyperplasia           |                2                       2           2                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                2         |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         | 1  2  1                             3     2           2     2        2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                        +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3        3  2     3  2     3  2  2     3  2  3  2  2  2  2  2  3  2  2|             
      Cyst                                 |                      X        X              X        X                  |             
      Hemorrhage, Acute                    |                               4                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 | +  +  A  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|             
                                           | 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Dilatation                           |          3                                                  4            |             
      Hemorrhage                           | 3                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 3     2  2  2  2        2  2  2  2  2  4  2  1  2  2  2  1     2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia                 |                                                                          |             
      Femoral, Myelofibrosis               |                                                                      2   |             
      Vertebral, Hyperplasia               |                                                                          |             
      Vertebral, Myelofibrosis             | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M  M  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Thrombosis                    |                                  X                                       |             
      Mandibular, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mandibular, Hyperplasia, Plasma Cell |                                              2                           |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                              2                           |             
      Renal, Thrombosis                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  M  M  M  M     +  +  M  M  +  M  M  M  M  +  M  M  M  M  M  +  M  +|             
      Angiectasis                          |                         2                       2                        |             
      Hyperplasia, Plasma Cell             |                                                 2                        |             
      Thrombosis                           |                                  X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  3        2  2        3  1  3  3  1  1     4  3  2        2  1  3  3  3|             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  M  M     +  +  +  +  M  +  M  +  M  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Cystic                  | 1  1     1  1  1        2     1  1  1  1  1     2  1  2     1     1  1  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|             
                                           | 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  M  M  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      White Matter, Degeneration           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
      Inflammation, Chronic                | 1                             1     3     2                       2     3|             
      Pigmentation, Hemosiderin            |                2                                   1                     |             
      Alveolar Epithelium, Hyperplasia     | 1                             2     3     2        1  2           2     2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Foreign Body      |                                                       1                  |             
      Nasolacrimal Duct, Granuloma         |                                                       2                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                         1              2                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                             +                           |             
      Lens, Cataract                       |                3                             4                           |             
      Retina, Atrophy                      |                3                             3                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  A  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                               3                                          |             
      Metaplasia, Osseous                  |                                              2                           |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Nephropathy, Chronic                 |                1        2  1  1  3  1  1        2  2  1  2  2  2  2      |             
      Renal Tubule, Regeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  | +        +     +        +        +  +  +     +  +        +        +  +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3|            |
                                           | 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  A  A  +  +  +  +  +  +  +  M  +  +  A  +  A  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  44        |
      Infarct                              |                                                                   4      |      1  4.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  43        |
      Parasite Metazoan                    |                                                                   X      |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  43        |
      Inflammation, Necrotizing            |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  42        |
      Necrosis, Coagulative                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                        2                                 |      1  2.0|
      Clear Cell Focus                     |                                     X                             X      |      2     |
      Hematopoietic Cell Proliferation     |                                           2                 3            |      2  2.5|
      Leukocytosis                         |                                                             X            |      1     |
      Necrosis, Coagulative                |                                                          3        2      |      3  2.7|
      Pigmentation, Hematoidin             |                                                       1                  |      1  1.0|
      Pigmentation, Hemosiderin            |                                                       2                  |      1  2.0|
      Vacuolization Cytoplasmic            |                                        2                                 |      2  2.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Necrosis                             |                                                          3               |      2  3.5|
      Thrombosis                           |                                                                   X      |      2     |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |                      2                                                   |      2  3.0|
      Acinus, Atrophy                      | 2           2                                                            |      4  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Acanthosis                           |    3                                                                    3|      5  2.8|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3|            |
                                           | 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Dysplasia                            |                                                                          |      3  2.3|
      Foreign Body                         |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +     +  +  +  +  +  +        +  +  +  +  +     +     +     +  +     +|  34        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy, Chronic              |                         2                                   3            |      4  2.3|
      Inflammation, Chronic Active         |                                                    2        3            |      2  2.5|
      Mineralization                       |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Corticomedullary Junction,           |                                                                          |            |
          Degeneration, Fatty              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Accessory Adrenal Cortical Nodule    |             X                          X     X                           |      3     |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                                             3            |      1  3.0|
      Hyperplasia                          |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                           2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  M  +  +  M  +  +  +  +  M  M  +  +  M  +  M  +  M  +  +  +  +|  28        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|  43        |
      Pars Distalis, Hyperplasia           | 2        2           3           2  2     1           1           1  2  1|     13  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |                                                          3               |      1  3.0|
      Follicle, Cyst                       |                                           X  X           X               |      3     |
      Follicular Cell, Hyperplasia         | 3                    2                                3                  |     11  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                +                                                         |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3|            |
                                           | 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              | 3  2     2        2     4  3  3  3  2  3  2  2  3  3  2  2  3        3  3|     38  2.5|
      Cyst                                 |          X                             X                                 |      6     |
      Hemorrhage, Acute                    |                                        4                                 |      2  4.0|
      Inflammation, Suppurative            |                                                    2                     |      1  2.0|
      Mineralization                       |                                        2                                 |      1  2.0|
      Thrombosis                           |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +  +     +  +        +     +  +        +  +  +        +  +     +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |                                  3        4                              |      4  3.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                    2              2      |      2  2.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 1  1  2  2  3  2  2  2  4  2  1  3  1  2  2  3  1     1  2  2  2  2  2  3|     45  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Femoral, Hyperplasia                 |                                                             4            |      1  4.0|
      Femoral, Myelofibrosis               |                                                                          |      1  2.0|
      Vertebral, Hyperplasia               |                                                             4            |      1  4.0|
      Vertebral, Myelofibrosis             | 2        2  2              1  1        1  1     2        2               |     10  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Iliac, Thrombosis                    |                                                                          |      1     |
      Mandibular, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                             4            |      1  4.0|
      Mandibular, Hyperplasia, Plasma Cell |                                                                2        2|      3  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Renal, Thrombosis                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  +  M  M  M  M  M  +  M  M  M  M  M  +  +  M  M  M  +  M  M  M  +  M|  13        |
      Angiectasis                          |                                           2                              |      3  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     | 2  1     2  2  2     2  4  2  2  3  3  1  3     1  2  2  4  4  2  4  2  3|     40  2.4|
      Infarct                              |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +|  38        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3|            |
                                           | 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  M  +  +  M  M  M  M  M  +  M  +  +  M  M  +  +  M  +  +  M  +  +|  33        |
      Hyperplasia, Cystic                  |       2     1  1                 1        1        1  1     2  1     1  2|     29  1.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Foreign Body                         |                2                                                         |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosis, Focal                      |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage, Acute                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  M  +  +  M  +  +  +  +  +  M  +  +  I  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      White Matter, Degeneration           |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage, Acute                    | 2                                                                        |      1  2.0|
      Inflammation, Chronic                |                               2     2  1     2  2     2        1     2   |     14  1.9|
      Pigmentation, Hemosiderin            |                            2                                             |      3  1.7|
      Alveolar Epithelium, Hyperplasia     |                               2     2  1  2  2        2        2  2  2   |     17  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                     2                                    |      1  2.0|
      Nasolacrimal Duct, Foreign Body      |                                                                          |      1  1.0|
      Nasolacrimal Duct, Granuloma         |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                            1     2                             1         |      5  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Lens, Cataract                       |                                                                          |      2  3.5|
      Retina, Atrophy                      |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3|            |
                                           | 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hydronephrosis                       |                                                                   3      |      1  3.0|
      Infarct                              | 2                          2                             4           2   |      5  2.6|
      Metaplasia, Osseous                  |    2     2                                                               |      3  2.0|
      Mineralization                       |                                                             2            |      1  2.0|
      Necrosis                             |                                                                   4      |      1  4.0|
      Nephropathy, Chronic                 | 2  2     1  1           1                 2           1     2           1|     23  1.6|
      Renal Tubule, Regeneration           |                                                                   4      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +           +        +     +     +     +  +     +     +  +  +  +  +     +|  26        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|             
                                           | 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  A|             
      Inflammation, Chronic Active         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X                                                               |             
      Hemorrhage                           |                                              4                           |             
      Hepatodiaphragmatic Nodule           |                X                                                         |             
      Leukocytosis                         |                X  X                                                      |             
      Mineralization                       |                2                                                         |             
      Necrosis, Coagulative                |                4                                            1            |             
      Pigmentation, Hematoidin             |                2                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          1                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    2           2              2  1     1        2  2  1        1  2  1  2|             
      Hyperkeratosis                       |                                                 3  2              3      |             
      Inflammation, Chronic Active         |                         3                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |    4                                                                     |             
      Inflammation, Chronic Active         |    4                 4                                               4   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Mesenteric Artery, Necrosis,         |                                                                          |             
          Fibrinoid                        |                                                                          |             
      Pulmonary Artery, Inflammation,      |                                                                          |             
          Chronic Active                   |                                                                          |             
      Pulmonary Artery, Necrosis, Fibrinoid|                                                                          |             
      Renal Artery, Inflammation, Chronic  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|             
                                           | 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Active                           |                                                                          |             
      Renal Artery, Necrosis, Fibrinoid    |                                                                          |             
      Renal Artery, Thrombosis             |                                                                          |             
      Thoracic, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
      Thoracic, Necrosis, Fibrinoid        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
      Coronary Artery, Necrosis, Fibrinoid |                                                                          |             
      Valve, Bacterium                     |                                                    X                     |             
      Valve, Thrombosis                    |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                  X                                       |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                 2           2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               3                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  M  +  M  +  +  M  M  M  M  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    X                                                     X               |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Fibrinoid                  |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |       +              +     +     +        +     +  +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |       +        +  +  +           +        +     +  +     +        +     +|             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |             +                                                            |             
      Mineralization                       |             3                                                            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                      +   |             
      Inflammation, Chronic Active         |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|             
                                           | 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +        +  +  +     +     +        +  +  +  +        +     +     +|             
      Dilatation                           |                                              4              4            |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                           +           +                  |             
      Neutrophilia                         |                                                       X                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia                 |                4     4                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Hyperplasia, Lymphoid    |                                                       3                  |             
      Mandibular, Hyperplasia, Plasma Cell |                                                       4                  |             
      Mandibular, Inflammation, Suppurative|                                                       2                  |             
      Mandibular, Necrosis                 |                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  M  M  M  +  +  +  M  M  M  +  M  +  M  +  M  +  M  M  M  +  M  +  M  M|             
      Angiectasis                          |             2  3  2           1                                          |             
      Hematopoietic Cell Proliferation     |             2  4  3           2                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                4  4              4                    4                 4|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M|             
      Cyst                                 |                                                 X                        |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                         3                                                |             
      Alopecia                             |                                                                          |             
      Fibrosis                             |                         3                                                |             
      Hyperkeratosis                       |                         2                                                |             
      Inflammation, Chronic Active         |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|             
                                           | 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Lymphatic, Ectasia                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Femur, Tibia, Metaplasia,     |                                                                          |             
           Osseous                         |             4                                                            |             
      Joint, Tarsal, Metaplasia, Osseous   | 4           4  4  4  4     4  4     4  4        4                    4   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Cerebrum, Necrosis, Fibrinoid|                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      White Matter, Degeneration           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +                                                                        |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                      2                                                   |             
      Inflammation, Chronic                |                         2                          2        2        2   |             
      Leukocytosis                         |                X                                                         |             
      Alveolar Epithelium, Hyperplasia     |                         2     2                    2        2        2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      3                                                   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                                                    3                     |             
      Inflammation, Suppurative            |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|             
                                           | 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy, Chronic                 | 1     1  1  1           1     1           3  2              1        1   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  | +  +  +  +     +  +  +     +  +  +     +  +  +  +  +  +  +     +         |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 | +  +     +  +  +  +        +  +        +  +           +     +            |             
      Concretion                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3|            |
                                           | 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  M  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |          X                                                               |      2     |
      Leukocytosis                         |                                                                          |      2     |
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                      2  3                 4                              |      5  2.8|
      Pigmentation, Hematoidin             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +  +  +     +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +   |  43        |
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |       2     2  1     2     1     2                 1           2         |     20  1.6|
      Hyperkeratosis                       |                                                                2         |      4  2.5|
      Inflammation, Chronic Active         |                                           2                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |       3                                                                  |      2  3.5|
      Inflammation, Chronic Active         |                                           2                              |      4  3.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +|  47        |
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic Active                  |             3                                                            |      1  3.0|
      Mesenteric Artery, Necrosis,         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3|            |
                                           | 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
          Fibrinoid                        |             4                                                            |      1  4.0|
      Pulmonary Artery, Inflammation,      |                                                                          |            |
          Chronic Active                   |             3                                                            |      1  3.0|
      Pulmonary Artery, Necrosis, Fibrinoid|             3                                                            |      1  3.0|
      Renal Artery, Inflammation, Chronic  |                                                                          |            |
          Active                           |             3                                                            |      1  3.0|
      Renal Artery, Necrosis, Fibrinoid    |             4                                                            |      1  4.0|
      Renal Artery, Thrombosis             |             X                                                            |      1     |
      Thoracic, Inflammation, Chronic      |                                                                          |            |
          Active                           |             2                                                            |      1  2.0|
      Thoracic, Necrosis, Fibrinoid        |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |             2                                                            |      1  2.0|
      Atrium, Thrombosis                   |                      X                                                   |      1     |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |             3                                                            |      1  3.0|
      Coronary Artery, Necrosis, Fibrinoid |             3                                                            |      1  3.0|
      Valve, Bacterium                     |                                                                          |      1     |
      Valve, Thrombosis                    |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Hyperplasia                          |    2                                                              2      |      2  2.0|
      Hypertrophy                          |                                                                   2      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|  48        |
      Hyperplasia                          |       2                                            2                     |      3  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  +  M  +  +  M  M  M  +  M  +  +  +  M  +  +  +  +  M  +  M|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |             3                                                            |      1  3.0|
      Necrosis, Fibrinoid                  |             3                                                            |      1  3.0|
      Follicular Cell, Hyperplasia         |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3|            |
                                           | 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                     M                                    |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |    +  +  +        +  +  +  +  +  +  +  +  +     +                 +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |    +  +     +     +  +  +  +     +  +     +        +        +            |  23        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                          +     +         |   3        |
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                       +                                    |   3        |
      Inflammation, Chronic Active         |             4                       4                                    |      3  3.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |             2              4                             4              3|      4  3.3|
      Artery, Necrosis, Fibrinoid          |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +  +  +        +  +  +  +  +  +  +  +  +        +  +        +  +   |  29        |
      Dilatation                           |                                  4  3                    3               |      5  3.6|
      Inflammation, Chronic Active         |                                  2                                   2   |      2  2.0|
      Inflammation, Suppurative            |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |          3                                                               |      1  3.0|
      Seminiferous Tubule, Atrophy         |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                         +                                                |   3        |
      Neutrophilia                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia                 |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |      1  4.0|
      Mandibular, Inflammation, Suppurative|                                                                          |      1  2.0|
      Mandibular, Necrosis                 |                                                          2               |      1  2.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |             2                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  +  +  M  M  M  M  +  M  M  +  M  +  +  +  +  M  M  M  M  M  +  +  M|  19        |
      Angiectasis                          |          2                       2     2     3                    2  2   |     10  2.1|
      Hematopoietic Cell Proliferation     |       1  3                       4           3  2                 3  2   |     11  2.6|
      Hyperplasia, Lymphoid                |                                        4                                 |      1  4.0|
      Hyperplasia, Reticulum Cell          |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3|            |
                                           | 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Depletion Lymphoid                   |                            3                             2               |      2  2.5|
      Hematopoietic Cell Proliferation     |                      4           3           3        2     4           3|     11  3.5|
      Necrosis                             |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  M  M  +  M  +  +  M  M  +  +  M  +  M  +  +  +  M|  36        |
      Cyst                                 |                   X  X                                                   |      3     |
      Necrosis                             |                                                          4               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                      2                       2                           |      3  2.3|
      Alopecia                             |                      X                                                   |      1     |
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperkeratosis                       |                      2                                                   |      2  2.0|
      Inflammation, Chronic Active         |          3           2           3           3              4  4         |      7  3.3|
      Inflammation, Suppurative            |                2                                                         |      1  2.0|
      Necrosis, Coagulative                |          4                                                               |      1  4.0|
      Lymphatic, Ectasia                   |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Joint, Femur, Tibia, Metaplasia,     |                                                                          |            |
           Osseous                         |                                                                          |      1  4.0|
      Joint, Tarsal, Metaplasia, Osseous   |    4  4        4  4  4  4        4     4  4  4  4  4        4            |     24  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute                    |                         2                                                |      1  2.0|
      Inflammation, Chronic Active         |             3                                                            |      1  3.0|
      Artery, Cerebrum, Necrosis, Fibrinoid|             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      White Matter, Degeneration           |             2                                                        1   |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage, Acute                    |                                                                2         |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3|            |
                                           | 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                               2  3              2                    2   |      8  2.1|
      Leukocytosis                         |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     | 2                    1           3              2                    2   |     10  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                      1                    2                              |      3  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                          3               |      1  3.0|
      Hydronephrosis                       |                                                          3               |      1  3.0|
      Infarct                              |             3                                                            |      2  3.0|
      Inflammation, Suppurative            |                            2                             2               |      3  2.3|
      Nephropathy, Chronic                 |       1  1              1        1  1           1     3     1  4  1  1   |     21  1.4|
      Artery, Inflammation, Chronic Active |          3  3                                                            |      2  3.0|
      Artery, Necrosis, Fibrinoid          |          2  4                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +     +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +     +|  39        |
      Inflammation, Chronic Active         |             3                                                            |      1  3.0|
      Inflammation, Suppurative            |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 | +        +  +  +  +  +  +  +  +     +  +     +     +     +  +  +  +     +|  30        |
      Concretion                           |                2                                         4               |      2  3.0|
      Inflammation, Chronic Active         |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |          2                                               3              2|      3  2.3|
      Inflammation, Chronic Active         |             2              4                                             |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|             
                                           | 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +  +        +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       A  M  +  +        +  A     +  +        +     A        A  A         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +  +        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +  +        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  M        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       M  M  +  M        A  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +  +        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +  +        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       A  +  +  +        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +  +        +  +     +  +        +     A        +  A         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        X                                 |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Inflammation, Necrotizing            |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +  +        +  +     +  +        +              +  +         |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +        +  +     +  +        +     A        +  +         |             
      Cyst                                 |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Inflammation, Chronic Active         |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 1  2     2  2  2  2        1  1  2                          1     3  2  2|             
      Hyperkeratosis                       |                            1                                             |             
      Inflammation, Chronic Active         |                                                                   3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                            M                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +  +  +  +        +  +     +  +        +     +        +  +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +  +  +        +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Valve, Bacterium                     |                                                             X            |             
      Valve, Inflammation, Suppurative     |                                                             3            |             
      Valve, Thrombosis                    |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +  +        +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +  +        +  +     +  M        +     +        +  +         |             
      Hyperplasia                          |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|             
                                           | 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  +        +  +     +  +        +     A        +  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  M  +  M        M  M     +  +        +     I        +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  +        +  +     M  M        +     M        +  +         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Ultimobranchial Cyst                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |       +  +  +           +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |       +  +  +  +        +  +     +           +     +        +  +         |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |       +                 +                                                |             
      Inflammation, Chronic Active         |                         3                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +  +        +  +     +                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Ectasia                        |       3                                                                  |             
      Lymphatic, Ectasia                   |       3                                                                  |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Inflammation, Chronic Active         |                4        4        1                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  M  +  M  +  +  +  +     +  M        +     +        +  +         |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |                         2                                                |             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Mineralization                       |       1                                                                  |             
      Interstitial Cell, Hyperplasia       |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Neutrophilia                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Femoral, Hyperplasia                 |                4                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +  +     +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |             3                                                            |             
      Mandibular, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                   3      |             
      Mandibular, Hyperplasia              |                                                                          |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       M  M  M  M  +     M  A  +  M  +  +     M     M  +  +  M  M  +     +|             
      Angiectasis                          |                                        2              4  2              2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|             
                                           | 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                        3              3  3        3     2|             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +  +        +  +  +  +  +  +     +     +        +  +  +      |             
      Hematopoietic Cell Proliferation     |          3     4                    4  4                          3      |             
      Necrosis                             |                         2                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  |       M  +  +  +        +  +     +  +        +     +        +  M         |             
      Necrosis                             |          3  4           4  3     3                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       M  M  M  M        M  M     M  M        M     M        M  M         |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +        +  +     +  +  +     +     +        +  +  +      |             
      Abscess                              |          3  3                                                            |             
      Inflammation, Chronic Active         |          4  4  3        3        3                                4      |             
      Inflammation, Suppurative            |       2                                                                  |             
      Metaplasia, Osseous                  |                                                                          |             
      Prepuce, Concretion                  |                                  4                                       |             
      Prepuce, Dilatation                  |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +   |             
      Joint, Femur, Tibia, Metaplasia,     |                                                                          |             
           Osseous                         |                                                                          |             
      Joint, Tarsal, Metaplasia, Osseous   |                      3        3        4  3           3  4     3     4   |             
      Sternum, Developmental Malformation  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +  +  +  +        +  +     +  +        +     +        +  +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +  +        +  +     +  +        +     +        +  +         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  M  M  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +|             
      Sciatic, Degeneration                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +  +  +  +        +  +     +  +        +     +        +  +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              2           2               |             
      Leukocytosis                         |                                                                X         |             
      Alveolar Epithelium, Hyperplasia     |                                     2     2  2  2  2  2  2               |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Foreign Body                         |          2                                                               |             
      Granuloma                            |          2                                                               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                     2                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +        +  +     +  +        +     +        +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|             
                                           | 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +        +  +     +  +        +     +        +  +         |             
      Bacterium                            |                X                                                         |             
      Hydronephrosis                       |                         3                                                |             
      Infarct                              |                                     2                       3            |             
      Inflammation, Suppurative            |                4        1        2                                       |             
      Mineralization                       |                         2                                      1         |             
      Nephropathy, Chronic                 |                                     1        1              2            |             
                                            __________________________________________________________________________|             
   Ureter                                  |       +     +  +           +     +  +        +              +            |             
                                            __________________________________________________________________________|             
   Urethra                                 |       +  +  +  +        +           +                       +            |             
      Concretion                           |          4  4           4                                                |             
      Inflammation, Chronic Active         |          4  4                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +  +        +  +     +  +        +     M        +  +        +|             
      Dilatation                           |             3           3        3                             3        2|             
      Inflammation, Chronic Active         |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3|            |
                                           | 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +           +  +                    +        +        +     +|  20        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          M  +           +  A                    +        +        +     +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  +           +  A                    +        +        +     +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          A  A           +  M                    +        +        +     +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +           +  A                    +        +        +     +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          A  +           +  A                    +        +        M     +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          A  +           +  A        +           +        +        +     +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          A  +           +  A                    +        +        +     +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          A  A           +  A                    +        +        +     +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          A  M           +  A        +           +        +        +     +|  16        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                          3               |      2  2.5|
      Inflammation, Necrotizing            |             2                                                            |      1  2.0|
      Necrosis, Coagulative                |             3  2                                2                        |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +  +           +  +                    +        +        +     +|  18        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +           +  +                 +  +        +        +     +|  21        |
      Cyst                                 |                                              X                           |      1     |
      Necrosis, Coagulative                |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +           +  +                    +        +        +     +|  20        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           | 2     1     1                 2  2        2  2  1                    1  2|     23  1.7|
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          A  +           +  +                    +        +     +  +     +|  20        |
      Cyst                                 |                                                                X         |      1     |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +  +           +  +                    +        +        +     +|  20        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +  +           +                       +        +        +     +|  19        |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +           +  +                    +        +        +     +|  20        |
      Valve, Bacterium                     |          X                                                               |      2     |
      Valve, Inflammation, Suppurative     |          4                                                               |      2  3.5|
      Valve, Thrombosis                    |          X                                                               |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3|            |
                                           | 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +  +           +  +                    +        +        +     +|  21        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +     +  +           +  +                    +        +        +     +|  21        |
      Hyperplasia                          |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +     +  +           +  +                    +        +        +     +|  20        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  +           +  +                    +        +        +     +|  19        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  M           +  M                    M        +        +     +|  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          I  +           +  M                    +        M        +  +  M|  14        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +           +  +                    +        +        +     +|  20        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |          +  +              +                    +        +        +     +|  18        |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |          +  +              +                                      +     +|  16        |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +  +           +  +                    +        +        +     +|  20        |
      Inflammation, Chronic Active         |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                          +                                             |   9        |
      Inflammation, Chronic Active         | 4                                                                        |      1  4.0|
      Duct, Ectasia                        |                                                                          |      1  3.0|
      Lymphatic, Ectasia                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |          +  +           +  +                    +        +        +     +|  20        |
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +              +                    +        +        +  +  +|  18        |
      Dilatation                           |                                                                      4   |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |          +  +           +  +                    +        +        +     +|  20        |
      Mineralization                       |                                                                          |      1  1.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                         +                                +               |   2        |
      Neutrophilia                         |                         X                                X               |      2     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +           +  +                    +        +        +     +|  20        |
      Femoral, Hyperplasia                 |                            4                             4               |      3  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3|            |
                                           | 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +     +     +  +  +  +     +        +        +        +     +|  32        |
      Hematopoietic Cell Proliferation     |       3                                                                  |      1  3.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Mandibular, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
      Mandibular, Hyperplasia              |                                  2                                       |      1  2.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          M  +     +     +  M  +  +     +        M        +        +     +|  17        |
      Angiectasis                          |                   2     2        3                       2        3     4|     10  2.6|
      Hematopoietic Cell Proliferation     |                   2     2        3     3                 2              2|     11  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +           +  +        +  +        +        +        +     +|  26        |
      Hematopoietic Cell Proliferation     |       3  4              3           3  3        4        4        3      |     13  3.5|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          M  M           M  +                    +        +        M     M|  13        |
      Necrosis                             |                            4                                             |      6  3.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M  M           M  M                    M        M        M     M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +     +  +  +        +  +  +  +  +     +        +  +  +|  33        |
      Abscess                              |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |    4                       2  2                                          |      9  3.2|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                 3                        |      1  3.0|
      Prepuce, Concretion                  |                                                                          |      1  4.0|
      Prepuce, Dilatation                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +     +  +  +  +  +  +  +           +  +  +  +        +     +|  34        |
      Joint, Femur, Tibia, Metaplasia,     |                                                                          |            |
           Osseous                         |                                  3                                       |      1  3.0|
      Joint, Tarsal, Metaplasia, Osseous   |             4     4  4        2  4  4              4  4                  |     16  3.6|
      Sternum, Developmental Malformation  |                                     X                                    |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +  +  +  +     +  +           +  +     +        +        +     +|  24        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +           +  +                    +        +        +     +|  20        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|  39        |
      Sciatic, Degeneration                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3|            |
                                           | 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    25 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |          +  +           +  +                    +        +        +     +|  20        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |          2              2  3  2        2  1     2  1  1  2               |     12  1.8|
      Leukocytosis                         |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |                2     1  2     2  2     2        2  1  1  2               |     17  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +           +  +                    +        +        +     +|  20        |
      Foreign Body                         |                                                                          |      1  2.0|
      Granuloma                            |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  +           +  +                    +        +        +     +|  20        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +        +                              |   2        |
      Lens, Cataract                       |                                  3        3                              |      2  3.0|
      Retina, Atrophy                      |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +           +  +           +     +  +        +        +     +|  22        |
      Bacterium                            |                                                                          |      1     |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Infarct                              |          4                                                               |      3  3.0|
      Inflammation, Suppurative            |                                                                          |      3  2.3|
      Mineralization                       |                            1                                             |      3  1.3|
      Nephropathy, Chronic                 |          2                                                               |      4  1.5|
                                            __________________________________________________________________________|____________|
   Ureter                                  |          +  +           +                       +        +        +     +|  15        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                            +                                             |   8        |
      Concretion                           |                            3                                             |      4  3.8|
      Inflammation, Chronic Active         |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +  +           +  +                    +        +        +     +|  21        |
      Dilatation                           |    4        4              3                                             |      8  3.1|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|             
                             DAY ON TEST   | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|             
                                           | 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  A  +  A  +  +  +  A  M  A  +  +  +  A  +  A  +  +  +  +  A  A  +  A|             
      Inflammation, Chronic Active         |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  A  +  +  +  A     +  +  +  +  A  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A     +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A     +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A     +  +  +  +  A  +  +  +  +  +  +  +  A     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  A  +  +  +  A     +  +  +  +  A  +  +  +  +  +  +  +  A     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  A     +  +  +  +  A  +  +  +  +  +  +  +  A     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                       X                  |             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Inflammation, Chronic                |    3                                                                     |             
      Leukocytosis                         |                                     X                             X      |             
      Necrosis, Coagulative                |    2     2              3                       3                 2     3|             
      Vacuolization Cytoplasmic            | 2  2                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2                                                            |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              2                           |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    1  2        2     1     2  2           1        4     1     4  1     1|             
      Acanthosis, Multiple                 |                                                                          |             
      Hyperkeratosis                       |    3  1                                                           1      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  A     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |    4                                               4        4        3   |             
      Foreign Body                         |                                                       1                  |             
      Inflammation, Chronic Active         | 3                                                     2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +     +  +     +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                                     2                    2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|             
                             DAY ON TEST   | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|             
                                           | 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                              2                          3|             
      Valve, Bacterium                     | X           X                                X                          X|             
      Valve, Thrombosis                    | X           X                                X                          X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | X                                                           X            |             
      Hyperplasia                          |                      2                                                   |             
      Hypertrophy                          |                                                    2  2     1            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                             2  2                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  A  +  +  M  M  M  +  +  M  M  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  M|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Dilatation                           |                                                    2                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |    +  +  +  +  +        +     +        +  +  +  +              +  +     +|             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                         +  +                                             |             
      Inflammation, Chronic Active         |                            4                                             |             
      Lymphatic, Ectasia                   |                         4                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +           +  +     +  +  +  +  +  +        +|             
      Dilatation                           |       4                                            4                     |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia                 |             4                       4                             4      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|             
                             DAY ON TEST   | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|             
                                           | 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hemorrhage, Acute          |                                                                   3      |             
      Axillary, Hyperplasia, Lymphoid      |                                                                   3      |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mandibular, Hyperplasia, Plasma Cell |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  M  +  +  M  +  M  +  M  +  M  +  M  +  M  M  M  M  +  M  M  +  +  M  M|             
      Angiectasis                          |          3     2     2     4     2                    2                  |             
      Hematopoietic Cell Proliferation     |                            2     3                                       |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  3  3     3  3  2  2     3  3  2  4        2           2  3  2  4  3  3|             
      Infarct                              |                         3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  A  M  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                2                                                         |             
      Edema                                |                         3                                                |             
      Fibrosis                             |                3                                                         |             
      Hyperkeratosis                       |                2                                                         |             
      Inflammation, Chronic Active         |                      3        3        3                                 |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Metaplasia, Osseous   |          4                    4        4  4              4        4      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
      Sciatic, Degeneration                |    2                 1              1                                    |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      White Matter, Degeneration           |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                               3                                          |             
      Inflammation, Chronic                |                2           2  2  1     1        2  3     2        2  3   |             
      Leukocytosis                         |                                                                   X      |             
      Alveolar Epithelium, Hyperplasia     |                2           2  2  1     2        2  3     2        2  2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|             
                             DAY ON TEST   | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|             
                                           | 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                     2                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Infarct                              | 3           4                       4        3              3            |             
      Inflammation, Suppurative            |                                     3                                    |             
      Mineralization                       |    2                                               2        2            |             
      Nephropathy, Chronic                 | 1        1  3     1  1     2     2                 2  2                  |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  | +  +     +  +  +  +  +  +  +  +     +  +  +     +        +  +  +        +|             
                                            __________________________________________________________________________|             
   Urethra                                 |    +  +     +     +  +     +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                     2                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                            3                                   4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3|            |
                                           | 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  A  +  +  +  +  A  A  A  +  +  +  +  +  M  +  +  +  +|  33        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  +  +  A  +  A  +  +  +  +  +  M  A  +  +     +  +  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  43        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  42        |
      Parasite Metazoan                    |                                                                         X|      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  A  +  A  +  +  +  M  +  +  A  +  +     +  +  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Leukocytosis                         |                                                                   X      |      3     |
      Necrosis, Coagulative                |                                        2                          3      |      8  2.5|
      Vacuolization Cytoplasmic            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         | 3           2                                                            |      3  2.3|
      Necrosis                             |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Necrosis, Coagulative                |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis, Coagulative                |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acanthosis                           | 1  2  2        1  1  1              1  1  2     3  1  2              2  1|     26  1.7|
      Acanthosis, Multiple                 |                                                             4            |      1  4.0|
      Hyperkeratosis                       |    3  3              1                                2              2   |      8  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Chronic Active         |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |                            3                          3           2  4   |      8  3.4|
      Foreign Body                         |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3|            |
                                           | 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +  +  +  +        +  +  +  +  +  +           +        +  +     +  +|  34        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              |                                  2                       2               |      4  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Valve, Bacterium                     |                                                                          |      4     |
      Valve, Thrombosis                    |                                        X                                 |      5     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      2     |
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |                      2     3                                             |      5  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          3        2                                                      |      5  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                            2                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|  42        |
      Pars Distalis, Cyst                  |          X                                                        X      |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         |                         1        1              2  2                     |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Dilatation                           |                                                                      4   |      2  3.0|
      Inflammation, Suppurative            | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         | +  +     +  +  +     +  +  +  +           +  +  +     +        +         |  28        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   | +              +                                   +           +         |   4        |
      Inflammation, Chronic Active         | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +           +                    +        +               |   6        |
      Inflammation, Chronic Active         |                            3                    3        2               |      4  3.0|
      Lymphatic, Ectasia                   |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3|            |
                                           | 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +     +  +  +  +  +  +  +     +     +     +  +  +  +     +  +  +   |  36        |
      Dilatation                           |                   2                                                  2   |      4  3.0|
      Inflammation, Chronic Active         |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia                 | 4                    4                                            4      |      6  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Hemorrhage, Acute          |                                                                          |      1  3.0|
      Axillary, Hyperplasia, Lymphoid      |                                                                          |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                2         |      1  2.0|
      Mandibular, Hyperplasia, Plasma Cell |          3              3                                                |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  M  M  +  M  M  M  M  M  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +|  24        |
      Angiectasis                          |    3        3                 3     3        2  2                 4  2   |     14  2.6|
      Hematopoietic Cell Proliferation     |                               3     2        2  2     2  2        3  4   |     10  2.5|
      Hyperplasia, Lymphoid                |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                          3               |      1  3.0|
      Hematopoietic Cell Proliferation     | 3  3        2  3        2  2  3  2  2  3     3  3  2  2  4  3  2  4  2  3|     38  2.7|
      Infarct                              |       4                                                                  |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M|   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  3.0|
      Fibrosis                             |                                                                      2   |      2  2.5|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 4                                                                 2     4|      6  3.2|
      Inflammation, Suppurative            |    3                 2                                                   |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Joint, Tarsal, Metaplasia, Osseous   |                         4     4     3                 4                 4|     11  3.9|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3|            |
                                           | 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|  43        |
      Sciatic, Degeneration                |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      White Matter, Degeneration           |                                              1                       1   |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute                    |          2                                                               |      2  2.5|
      Inflammation, Chronic                |          1  3  2                 2     1              2  3  2     1     4|     20  2.1|
      Leukocytosis                         |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |          1     2     2           2     2              3  3  2     2      |     19  2.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                         3                                                |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |       3                                            3                     |      3  2.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +              +                          +           +         |   4        |
      Cornea, Inflammation, Chronic Active |                         4                                                |      1  4.0|
      Lens, Cataract                       |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  1                                       |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                       4                  |      1  4.0|
      Cyst                                 |          X                                                               |      1     |
      Infarct                              |          2                    2        4                                 |      8  3.1|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       | 2  1                 1           1                       1               |      8  1.5|
      Nephropathy, Chronic                 |             2     2     1  2     2  2  2     2  1     2        2     2  2|     22  1.8|
      Thrombosis                           |                                        X                                 |      1     |
                                            __________________________________________________________________________|____________|
   Ureter                                  |    +     +  +  +        +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Urethra                                 | +     +  +        +     +  +  +  +  +  +     +     +  +  +     +        +|  35        |
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05024-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:02:46  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3|            |
                                           | 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
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