National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3740

TDMS Study 05024-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                        N-METHYLOLACRYLAMIDE


NTP Experiment-Test: 05024-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 03:20:11




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  924-42-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05024-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:11  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          10           20           12                                                  
    Dead                                               5            8            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           22           33                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (16)         (50)                                                
      Foreign Body                                                  1 (6%)       1 (2%)                                             
      Inflammation, Chronic Active                                  1 (6%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
   Intestine Large, Cecum                             (48)         (14)         (48)                                                
      Parasite Metazoan                                             1 (7%)                                                          
   Intestine Large, Colon                             (48)         (16)         (49)                                                
      Parasite Metazoan                                1 (2%)                    4 (8%)                                             
   Intestine Large, Rectum                            (46)         (16)         (46)                                                
      Parasite Metazoan                                3 (7%)       1 (6%)       1 (2%)                                             
   Intestine Small, Duodenum                          (49)         (16)         (50)                                                
      Diverticulum                                     1 (2%)                                                                       
   Liver                                              (50)         (21)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                40 (80%)      7 (33%)     37 (74%)                                            
      Clear Cell Focus                                 1 (2%)                                                                       
      Degeneration, Cystic                                                       2 (4%)                                             
      Hepatodiaphragmatic Nodule                       6 (12%)      2 (10%)      5 (10%)                                            
      Inflammation, Chronic                           27 (54%)      7 (33%)     29 (58%)                                            
      Inflammation, Necrotizing                        4 (8%)                                                                       
      Necrosis, Coagulative                            1 (2%)                    2 (4%)                                             
      Vacuolization Cytoplasmic                        2 (4%)       1 (5%)                                                          
      Portal Vein, Necrosis, Fibrinoid                 1 (2%)                                                                       
      Portal Vein, Intima, Proliferation               1 (2%)                                                                       
   Mesentery                                          (49)         (18)         (49)                                                
      Inflammation, Chronic Active                     1 (2%)       2 (11%)      1 (2%)                                             
      Necrosis                                                      2 (11%)      1 (2%)                                             
   Pancreas                                           (50)         (17)         (50)                                                
      Acinus, Atrophy                                  6 (12%)      2 (12%)     10 (20%)                                            
      Duct, Ectasia                                                              1 (2%)                                             
   Salivary Glands                                    (50)         (16)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (16)         (50)                                                
      Inflammation, Chronic Active                     2 (4%)       1 (6%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05024-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:11  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Stomach, Glandular                                 (49)         (16)         (50)                                                
      Inflammation, Chronic Active                                  2 (13%)                                                         
      Mineralization                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (16)         (47)                                                
      Pulmonary Artery, Mineralization                 1 (2%)                                                                       
   Heart                                              (50)         (16)         (50)                                                
      Cardiomyopathy, Chronic                         47 (94%)      7 (44%)     48 (96%)                                            
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Atrium, Thrombosis                                            1 (6%)       1 (2%)                                             
      Valve, Bacterium                                              1 (6%)       1 (2%)                                             
      Valve, Inflammation, Chronic Active                           1 (6%)                                                          
      Valve, Thrombosis                                             1 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)         (50)                                                
      Capsule, Inflammation, Chronic                                1 (2%)                                                          
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                    1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Degeneration, Fatty                             10 (20%)     17 (34%)     16 (32%)                                            
      Hyperplasia                                     13 (26%)     16 (32%)     18 (36%)                                            
      Hypertrophy                                      2 (4%)       5 (10%)      8 (16%)                                            
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Hyperplasia                                      4 (8%)       5 (10%)      6 (12%)                                            
   Pituitary Gland                                    (49)         (40)         (50)                                                
      Pars Distalis, Angiectasis                                                 6 (12%)                                            
      Pars Distalis, Cyst                             14 (29%)     10 (25%)     25 (50%)                                            
      Pars Distalis, Hyperplasia                      11 (22%)     11 (28%)     12 (24%)                                            
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
   Thyroid Gland                                      (50)         (17)         (50)                                                
      C-Cell, Hyperplasia                             20 (40%)      3 (18%)     14 (28%)                                            
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05024-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:11  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (17)         (50)                                                
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)       1 (6%)       1 (2%)                                             
      Duct, Dilatation                                 1 (2%)                                                                       
   Ovary                                              (50)         (20)         (50)                                                
      Cyst                                             4 (8%)       4 (20%)      3 (6%)                                             
   Uterus                                             (50)         (19)         (50)                                                
      Dilatation                                       6 (12%)                   6 (12%)                                            
      Diverticulum                                                  1 (5%)       1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)       2 (11%)                                                         
      Cervix, Fibrosis                                                           1 (2%)                                             
      Endometrium, Hyperplasia, Cystic, Glandular      8 (16%)      1 (5%)      14 (28%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (16)         (50)                                                
      Femoral, Hyperplasia                                                       1 (2%)                                             
      Femoral, Hyperplasia, Reticulum Cell             5 (10%)      3 (19%)      3 (6%)                                             
      Femoral, Myelofibrosis                                        1 (6%)       1 (2%)                                             
      Femoral, Myeloid Cell, Hyperplasia                            1 (6%)                                                          
      Vertebral, Hyperplasia                                                     1 (2%)                                             
   Lymph Node                                         (50)         (21)         (50)                                                
      Mandibular, Hyperplasia, Plasma Cell                          1 (5%)       1 (2%)                                             
      Mandibular, Pigmentation, Hemosiderin                                      1 (2%)                                             
      Mediastinal, Inflammation, Necrotizing                        1 (5%)                                                          
      Mediastinal, Pigmentation, Hemosiderin          37 (74%)                  37 (74%)                                            
      Pancreatic, Pigmentation, Hemosiderin            1 (2%)                                                                       
   Spleen                                             (50)         (22)         (50)                                                
      Fibrosis                                                      1 (5%)                                                          
      Hematopoietic Cell Proliferation                26 (52%)      2 (9%)      32 (64%)                                            
      Pigmentation, Hemosiderin                       31 (62%)                  32 (64%)                                            
      Thrombosis                                                    1 (5%)                                                          
   Thymus                                             (38)         (16)         (41)                                                
      Cyst                                             2 (5%)                    4 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05024-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:11  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (24)         (50)                                                
      Hyperplasia, Cystic                             48 (98%)     18 (75%)     48 (96%)                                            
   Skin                                               (50)         (24)         (50)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (16)         (50)                                                
      Femur, Fibrous Osteodystrophy                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (16)         (50)                                                
      Compression                                     14 (28%)      4 (25%)     13 (26%)                                            
      Hydrocephalus                                                 2 (13%)      2 (4%)                                             
      Inflammation, Chronic Active                                  1 (6%)                                                          
   Spinal Cord                                        (50)         (16)         (50)                                                
      White Matter, Degeneration                      18 (36%)                  11 (22%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (17)         (50)                                                
      Granuloma                                                     7 (41%)      5 (10%)                                            
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Pigmentation, Hemosiderin                                     1 (6%)                                                          
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    3 (6%)                                             
   Nose                                               (50)         (16)         (50)                                                
      Inflammation, Chronic Active                     3 (6%)                    1 (2%)                                             
      Nasolacrimal Duct, Granuloma                                               1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic        20 (40%)                  20 (40%)                                            
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (5)          (6)                                                 
      Lens, Cataract                                   2 (40%)      2 (40%)      5 (83%)                                            
      Retina, Atrophy                                  2 (40%)      1 (20%)      3 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05024-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:11  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (17)         (50)                                                
      Bacterium                                                     1 (6%)       1 (2%)                                             
      Calculus Micro Observation Only                  2 (4%)                                                                       
      Hydronephrosis                                   2 (4%)                                                                       
      Infarct                                                       1 (6%)                                                          
      Inflammation, Chronic Active                     2 (4%)       1 (6%)       1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Nephropathy, Chronic                            48 (96%)     11 (65%)     44 (88%)                                            
      Pigmentation, Hemosiderin                                     1 (6%)                                                          
      Renal Tubule, Atrophy                            1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
   Urinary Bladder                                    (50)         (14)         (50)                                                
      Calculus Micro Observation Only                  1 (2%)                                                                       
      Dilatation                                                    1 (7%)                                                          
      Inflammation, Chronic Active                                  1 (7%)                                                          
      Transitional Epithelium, Hyperplasia             2 (4%)       1 (7%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05024-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:11  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          15           21           19                                                  
    Dead                                               7            7            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           21           27                                                  
    Moribund                                                        1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (16)         (50)                                                
      Foreign Body                                                  1 (6%)                                                          
      Inflammation, Necrotizing                        1 (2%)                                                                       
   Intestine Large, Colon                             (49)         (14)         (50)                                                
      Parasite Metazoan                                4 (8%)                    6 (12%)                                            
   Intestine Large, Rectum                            (49)         (15)         (49)                                                
      Inflammation, Chronic Active                                  1 (7%)                                                          
      Parasite Metazoan                                3 (6%)       1 (7%)       4 (8%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Basophilic Focus                                 7 (14%)     14 (28%)      5 (10%)                                            
      Clear Cell Focus                                 1 (2%)       1 (2%)       1 (2%)                                             
      Clear Cell Focus, Multiple                                                 1 (2%)                                             
      Degeneration, Cystic                            10 (20%)      8 (16%)     19 (38%)                                            
      Eosinophilic Focus                                                         1 (2%)                                             
      Fatty Change                                     2 (4%)                                                                       
      Hepatodiaphragmatic Nodule                       2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            3 (6%)       7 (14%)      7 (14%)                                            
      Inflammation, Necrotizing                        1 (2%)                                                                       
      Leukocytosis                                                  1 (2%)                                                          
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Necrosis, Coagulative                            2 (4%)       2 (4%)       5 (10%)                                            
      Vacuolization Cytoplasmic                        1 (2%)       4 (8%)       1 (2%)                                             
   Pancreas                                           (50)         (17)         (50)                                                
      Cyst                                                          1 (6%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Acinus, Atrophy                                 15 (30%)      9 (53%)     15 (30%)                                            
      Acinus, Hyperplasia                                                        1 (2%)                                             
      Artery, Inflammation, Proliferative                           3 (18%)                                                         
   Salivary Glands                                    (50)         (15)         (49)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
   Stomach, Forestomach                               (50)         (15)         (50)                                                
      Inflammation, Chronic Active                     2 (4%)       2 (13%)      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05024-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:11  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mineralization                                                             1 (2%)                                             
      Epithelium, Hyperplasia                                       1 (7%)                                                          
   Stomach, Glandular                                 (50)         (14)         (50)                                                
      Mineralization                                   1 (2%)                    3 (6%)                                             
      Necrosis, Coagulative                            1 (2%)                                                                       
   Tooth                                              (49)         (16)         (50)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (16)         (48)                                                
      Aorta, Mineralization                                                      1 (2%)                                             
      Mesenteric Artery, Mineralization                1 (2%)                                                                       
      Mesenteric Artery, Intima, Proliferation         1 (2%)                                                                       
      Pulmonary Artery, Mineralization                                           1 (2%)                                             
   Heart                                              (50)         (21)         (50)                                                
      Cardiomyopathy, Chronic                         48 (96%)     16 (76%)     48 (96%)                                            
      Infarct                                          1 (2%)                                                                       
      Mineralization                                   3 (6%)                                                                       
      Atrium, Thrombosis                               3 (6%)       6 (29%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                                          1 (2%)                                             
      Degeneration, Fatty                              8 (16%)     12 (24%)      9 (18%)                                            
      Hyperplasia                                     10 (20%)     10 (20%)     15 (30%)                                            
      Hypertrophy                                      1 (2%)       2 (4%)       4 (8%)                                             
      Mineralization                                                1 (2%)                                                          
      Necrosis, Coagulative                            1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)         (50)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Atypia Cellular                                               1 (2%)                                                          
      Hyperplasia                                     13 (27%)     24 (48%)     16 (32%)                                            
      Necrosis, Coagulative                                                      2 (4%)                                             
   Islets, Pancreatic                                 (50)         (14)         (50)                                                
      Vacuolization Cytoplasmic                                     1 (7%)                                                          
   Parathyroid Gland                                  (48)         (14)         (45)                                                
      Hyperplasia                                      1 (2%)       2 (14%)      3 (7%)                                             
   Pituitary Gland                                    (50)         (23)         (50)                                                
      Pars Distalis, Cyst                              4 (8%)       1 (4%)       2 (4%)                                             
      Pars Distalis, Hyperplasia                      18 (36%)      3 (13%)     15 (30%)                                            
      Pars Distalis, Pigmentation, Hemosiderin         1 (2%)                                                                       
      Pars Intermedia, Angiectasis                                               1 (2%)                                             
      Pars Intermedia, Cyst                            2 (4%)                    2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05024-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:11  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (50)         (17)         (50)                                                
      Mineralization                                   1 (2%)                                                                       
      C-Cell, Hyperplasia                              9 (18%)      5 (29%)     17 (34%)                                            
      Follicular Cell, Hyperplasia                     1 (2%)       7 (41%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (36)         (13)         (32)                                                
      Inflammation, Chronic Active                     2 (6%)                                                                       
   Epididymis                                         (50)         (16)         (49)                                                
      Angiectasis                                                                1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
   Preputial Gland                                    (49)         (17)         (48)                                                
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                    42 (86%)     16 (94%)     42 (88%)                                            
   Prostate                                           (50)         (19)         (49)                                                
      Abscess                                          1 (2%)                                                                       
      Atrophy                                                                    1 (2%)                                             
      Inflammation, Chronic Active                    29 (58%)     14 (74%)     30 (61%)                                            
   Seminal Vesicle                                    (35)         (16)         (40)                                                
      Inflammation, Chronic Active                                  1 (6%)                                                          
   Testes                                             (50)         (48)         (50)                                                
      Hyperplasia                                                   2 (4%)                                                          
      Mineralization                                  17 (34%)     19 (40%)     10 (20%)                                            
      Interstitial Cell, Hyperplasia                  25 (50%)     28 (58%)     27 (54%)                                            
      Perivascular, Atrophy                                         1 (2%)                                                          
      Rete Testes, Hyperplasia                                      1 (2%)                                                          
      Seminiferous Tubule, Atrophy                    40 (80%)     40 (83%)     46 (92%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (16)         (50)                                                
      Femoral, Hyperplasia                             1 (2%)                                                                       
      Femoral, Hyperplasia, Reticulum Cell             1 (2%)                    1 (2%)                                             
      Femoral, Myelofibrosis                                        1 (6%)       1 (2%)                                             
      Vertebral, Hyperplasia                           1 (2%)                                                                       
      Vertebral, Hyperplasia, Reticulum Cell                                     1 (2%)                                             
      Vertebral, Myelofibrosis                                                   1 (2%)                                             
   Lymph Node                                         (50)         (25)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05024-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:11  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Bronchial, Pigmentation, Hemosiderin             3 (6%)                    1 (2%)                                             
      Mandibular, Cyst                                 4 (8%)                    1 (2%)                                             
      Mandibular, Hyperplasia, Plasma Cell             3 (6%)       1 (4%)       1 (2%)                                             
      Mediastinal, Hemorrhage                          1 (2%)                                                                       
      Mediastinal, Hyperplasia, Plasma Cell                         1 (4%)                                                          
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   1 (2%)                                                                       
      Mediastinal, Inflammation, Chronic Active                     1 (4%)                                                          
      Mediastinal, Pigmentation, Hemosiderin           1 (2%)                    2 (4%)                                             
      Renal, Hemorrhage                                1 (2%)                                                                       
      Renal, Pigmentation, Hemosiderin                                           1 (2%)                                             
   Lymph Node, Mesenteric                             (15)         (6)          (8)                                                 
      Cyst                                                          1 (17%)                                                         
      Hemorrhage                                       2 (13%)                                                                      
      Infiltration Cellular, Histiocyte                1 (7%)                                                                       
      Inflammation, Proliferative                                   1 (17%)                                                         
   Spleen                                             (50)         (47)         (50)                                                
      Fibrosis                                         5 (10%)     10 (21%)      9 (18%)                                            
      Hematopoietic Cell Proliferation                18 (36%)      1 (2%)       8 (16%)                                            
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infarct                                                                    1 (2%)                                             
      Infiltration Cellular, Lipocyte                  1 (2%)                                                                       
      Necrosis, Coagulative                            1 (2%)                                                                       
      Pigmentation, Hemosiderin                                                  3 (6%)                                             
   Thymus                                             (37)         (14)         (35)                                                
      Cyst                                             3 (8%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (37)         (15)         (39)                                                
      Hyperplasia, Cystic                             37 (100%)    12 (80%)     36 (92%)                                            
   Skin                                               (50)         (25)         (50)                                                
      Cyst Epithelial Inclusion                                     1 (4%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)       2 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (16)         (50)                                                
      Cranium, Fibrous Osteodystrophy                  1 (2%)                    2 (4%)                                             
      Femur, Fibrous Osteodystrophy                    1 (2%)                    2 (4%)                                             
      Vertebra, Fibrous Osteodystrophy                 1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05024-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:11  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (48)         (16)         (50)                                                
      Compression                                      4 (8%)       4 (25%)      9 (18%)                                            
      Hemorrhage                                       3 (6%)       1 (6%)       1 (2%)                                             
      Hydrocephalus                                    2 (4%)       5 (31%)      2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Thrombosis                                                                 1 (2%)                                             
      White Matter, Degeneration                       1 (2%)                                                                       
   Spinal Cord                                        (50)         (15)         (49)                                                
      Hemorrhage, Acute                                1 (2%)                                                                       
      White Matter, Degeneration                      19 (38%)                  21 (43%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (17)         (49)                                                
      Bacterium                                                     1 (6%)                                                          
      Granuloma                                                     2 (12%)                                                         
      Inflammation, Chronic Active                     4 (8%)       2 (12%)      1 (2%)                                             
      Metaplasia, Osseous                                           1 (6%)                                                          
      Mineralization                                   1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                                           1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Adenomatous    3 (6%)       2 (12%)      3 (6%)                                             
      Artery, Mediastinum, Necrosis, Fibrinoid         1 (2%)                    1 (2%)                                             
      Interstitium, Inflammation, Chronic                                        4 (8%)                                             
      Mediastinum, Inflammation, Chronic Active        1 (2%)                    1 (2%)                                             
   Nose                                               (50)         (16)         (50)                                                
      Inflammation, Chronic Active                     4 (8%)       1 (6%)       2 (4%)                                             
      Inflammation, Suppurative                                     1 (6%)                                                          
      Nasolacrimal Duct, Inflammation, Chronic        15 (30%)                  12 (24%)                                            
      Nasolacrimal Duct, Inflammation, Suppurative     4 (8%)                    3 (6%)                                             
   Trachea                                            (50)         (15)         (50)                                                
      Inflammation, Chronic Active                     1 (2%)       1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (6)          (6)                                                 
      Hemorrhage                                                    1 (17%)      1 (17%)                                            
      Lens, Cataract                                   1 (33%)      1 (17%)      2 (33%)                                            
      Retina, Atrophy                                  1 (33%)      2 (33%)      2 (33%)                                            
   Harderian Gland                                    (8)          (12)         (8)                                                 
      Hemorrhage                                                                 1 (13%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05024-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:11  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (36)         (50)                                                
      Cyst                                             6 (12%)      8 (22%)      6 (12%)                                            
      Hydronephrosis                                   1 (2%)                                                                       
      Inflammation, Chronic                                         1 (3%)                                                          
      Mineralization                                   1 (2%)                                                                       
      Nephropathy, Chronic                            50 (100%)    36 (100%)    50 (100%)                                           
   Urinary Bladder                                    (50)         (18)         (49)                                                
      Inflammation, Chronic Active                     1 (2%)       2 (11%)      1 (2%)                                             
      Transitional Epithelium, Hyperplasia             1 (2%)                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.