National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3744

TDMS Study 05024-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                        N-METHYLOLACRYLAMIDE


NTP Experiment-Test: 05024-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 03:20:15




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  924-42-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05024-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          10           20           12                                                  
    Dead                                               5            8            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           22           33                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (49)         (16)         (50)                                                
   Intestine Small, Ileum                             (46)         (16)         (48)                                                
   Intestine Small, Jejunum                           (48)         (16)         (48)                                                
   Liver                                              (50)         (21)         (50)                                                
   Mesentery                                          (49)         (18)         (49)                                                
   Pancreas                                           (50)         (17)         (50)                                                
   Salivary Glands                                    (50)         (16)         (50)                                                
   Stomach, Forestomach                               (49)         (16)         (50)                                                
      Squamous Cell Papilloma                                       1 (6%)                                                          
   Stomach, Glandular                                 (49)         (16)         (50)                                                
   Tongue                                                                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (16)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                          3 (6%)       1 (2%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Pheochromocytoma Benign                          1 (2%)       1 (2%)       2 (4%)                                             
   Islets, Pancreatic                                 (50)         (16)         (50)                                                
      Adenoma                                                                    2 (4%)                                             
   Parathyroid Gland                                  (34)         (15)         (42)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (49)         (40)         (50)                                                
      Pars Distalis, Adenoma                          19 (39%)     19 (48%)     14 (28%)                                            
   Thyroid Gland                                      (50)         (17)         (50)                                                
      C-Cell, Adenoma                                 11 (22%)      2 (12%)      7 (14%)                                            
                                                             Page   2                                                               
NTP Experiment-Test: 05024-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                         2 (4%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (17)         (50)                                                
      Adenoma                                          2 (4%)       2 (12%)      4 (8%)                                             
   Ovary                                              (50)         (20)         (50)                                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
   Uterus                                             (50)         (19)         (50)                                                
      Polyp                                            1 (2%)                    1 (2%)                                             
      Polyp Stromal                                    6 (12%)      2 (11%)      6 (12%)                                            
      Polyp Stromal, Multiple                          1 (2%)                    2 (4%)                                             
      Sarcoma Stromal                                               3 (16%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (16)         (50)                                                
   Lymph Node                                         (50)         (21)         (50)                                                
   Lymph Node, Mesenteric                             (3)          (4)          (6)                                                 
   Spleen                                             (50)         (22)         (50)                                                
   Thymus                                             (38)         (16)         (41)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (24)         (50)                                                
      Adenocarcinoma                                   1 (2%)       1 (4%)       1 (2%)                                             
      Fibroadenoma                                    15 (31%)      9 (38%)     13 (26%)                                            
      Fibroadenoma, Multiple                           4 (8%)                    4 (8%)                                             
   Skin                                               (50)         (24)         (50)                                                
      Trichoepithelioma                                1 (2%)                                                                       
      Sebaceous Gland, Adenoma                                                   1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  1 (4%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (4%)                                                          
      Subcutaneous Tissue, Myxoma                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05024-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (16)         (50)                                                
      Cranium, Osteosarcoma                                         1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Spinal Cord                                        (50)         (16)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (17)         (50)                                                
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (1)                                                              
      Carcinoma                                        1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (17)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            14 (28%)     11 (22%)     15 (30%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05024-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          36          42                                                   
     Total Primary Neoplasms                           86          56          78                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39          28          36                                                   
     Total Benign Neoplasms                            68          38          60                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          16          18                                                   
     Total Malignant Neoplasms                         18          18          18                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05024-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          15           21           19                                                  
    Dead                                               7            7            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           21           27                                                  
    Moribund                                                        1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (14)         (50)                                                
   Intestine Large, Rectum                            (49)         (15)         (49)                                                
   Intestine Small, Ileum                             (48)         (14)         (50)                                                
   Intestine Small, Jejunum                           (49)         (14)         (50)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Neoplastic Nodule                                4 (8%)       1 (2%)                                                          
   Mesentery                                          (47)         (16)         (50)                                                
      Lipoma                                                                     1 (2%)                                             
   Pancreas                                           (50)         (17)         (50)                                                
   Salivary Glands                                    (50)         (15)         (49)                                                
   Stomach, Forestomach                               (50)         (15)         (50)                                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (14)         (50)                                                
   Tongue                                                                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
   Tooth                                              (49)         (16)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (21)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                                       2 (4%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (50)         (50)                                                
      Pheochromocytoma Malignant                       2 (4%)       2 (4%)                                                          
      Pheochromocytoma Benign                         10 (20%)      7 (14%)     11 (22%)                                            
                                                             Page   6                                                               
NTP Experiment-Test: 05024-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Bilateral, Pheochromocytoma Benign               8 (16%)                   2 (4%)                                             
   Islets, Pancreatic                                 (50)         (14)         (50)                                                
      Adenoma                                                                    2 (4%)                                             
   Parathyroid Gland                                  (48)         (14)         (45)                                                
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (23)         (50)                                                
      Pars Distalis, Adenoma                          18 (36%)     14 (61%)     13 (26%)                                            
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
   Thyroid Gland                                      (50)         (17)         (50)                                                
      C-Cell, Adenoma                                  7 (14%)      4 (24%)      9 (18%)                                            
      C-Cell, Carcinoma                                1 (2%)                    1 (2%)                                             
      Follicular Cell, Carcinoma                                    1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (16)         (49)                                                
   Preputial Gland                                    (49)         (17)         (48)                                                
      Adenoma                                          2 (4%)       2 (12%)      3 (6%)                                             
      Squamous Cell Carcinoma                                       1 (6%)                                                          
   Prostate                                           (50)         (19)         (49)                                                
   Testes                                             (50)         (48)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           33 (66%)     33 (69%)     38 (76%)                                            
      Interstitial Cell, Adenoma                       7 (14%)      8 (17%)      8 (16%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                       (2)                                                 
   Bone Marrow                                        (50)         (16)         (50)                                                
      Femoral, Vertebral, Histiocytic Sarcoma          1 (2%)                                                                       
   Lymph Node                                         (50)         (25)         (50)                                                
      Mediastinal, Carcinosarcoma, Metastatic, Lung    1 (2%)                                                                       
   Lymph Node, Mesenteric                             (15)         (6)          (8)                                                 
   Spleen                                             (50)         (47)         (50)                                                
      Hemangioma                                       1 (2%)                                                                       
      Sarcoma                                          1 (2%)                                                                       
   Thymus                                             (37)         (14)         (35)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05024-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (37)         (15)         (39)                                                
      Adenocarcinoma                                                             1 (3%)                                             
      Adenoma                                                                    1 (3%)                                             
      Fibroadenoma                                     2 (5%)       1 (7%)       1 (3%)                                             
   Skin                                               (50)         (25)         (50)                                                
      Basal Cell Adenoma                               1 (2%)       1 (4%)       1 (2%)                                             
      Basosquamous Tumor Benign                        1 (2%)                                                                       
      Keratoacanthoma                                  1 (2%)       6 (24%)      3 (6%)                                             
      Squamous Cell Papilloma                          1 (2%)       2 (8%)                                                          
      Sebaceous Gland, Adenoma                         1 (2%)       1 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     3 (6%)       1 (4%)       2 (4%)                                             
      Subcutaneous Tissue, Fibroma, Multiple                        1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (50)         (16)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (48)         (16)         (50)                                                
      Astrocytoma Malignant                                                      1 (2%)                                             
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
      Glioma Malignant                                              1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (17)         (49)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Carcinosarcoma                                   1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                                                       
   Nose                                               (50)         (16)         (50)                                                
      Nasolacrimal Duct, Squamous Cell Carcinoma       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                       (1)                                                 
      Adenoma                                          1 (100%)                                                                     
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05024-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (36)         (50)                                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                                                       
   Urinary Bladder                                    (50)         (18)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                            18 (36%)     18 (36%)     24 (48%)                                            
      Mesothelioma Malignant                           1 (2%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05024-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 03:20:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      6 MG/KG      12 MG/KG                                               
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          49          49                                                   
     Total Primary Neoplasms                          131         109         129                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          48          49                                                   
     Total Benign Neoplasms                           105          84          98                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          23          29                                                   
     Total Malignant Neoplasms                         26          25          31                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       1                                                   
     Total Metastatic Neoplasm                          3                       1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 57283-57283/57283


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.