Share This:
https://ntp.niehs.nih.gov/go/3748

TDMS Study 05024-01 Pathology Tables

NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97
Route: GAVAGE                                                                                                     Time: 12:28:08




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  924-42-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 2| 3| 3| 5| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 2| 2| 3| 1| 1| 3| 5| 1| 9| 1| 1| 2| 2| 3| 3| 1| 6| 2| 2| 2| 2| 2| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                              X         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X  X  X  X  X     X  X     X     X  X     X  X  X  X  X  X  X   |             
      Clear Cell Focus                     |                                                                          |             
      Hepatodiaphragmatic Nodule           | X                                            X  X                        |             
      Inflammation, Chronic                | 2  2  1  2  1  1              1     1  2     1  2  2  2  1  2  1  1      |             
      Inflammation, Necrotizing            |                   1                                                      |             
      Necrosis, Coagulative                |                         4                                                |             
      Vacuolization Cytoplasmic            |                                  3                                       |             
      Portal Vein, Necrosis, Fibrinoid     |                                                                          |             
      Portal Vein, Intima, Proliferation   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                      4   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               1                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         2                                                |             
      Ulcer                                |                         2                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pulmonary Artery, Mineralization     |                                  4                                       |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  3  2     1  2  2        2  2  2  2  3  2  1  2  2  2  2  2  3  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 2| 3| 3| 5| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 2| 2| 3| 1| 1| 3| 5| 1| 9| 1| 1| 2| 2| 3| 3| 1| 6| 2| 2| 2| 2| 2| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Accessory Adrenal Cortical Nodule    |                X                                                         |             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty                  |       2  2     1     2              1     2  2     2                     |             
      Hyperplasia                          | 2     2              3        2           3  2  2  2           2         |             
      Hypertrophy                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2     1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  M  +  +  M  M  +  M  M  +  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    X              X  X              X        X        X           X      |             
      Pars Distalis, Hyperplasia           | 2                          2  2              2                    2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1        1     2  1  1           1  1  2  1                 1  2  1     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     |       4                                                                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 | +  +           +  +  +  +  +  +     +  +  +  +  +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                        4              3                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                3  1           2              1                       2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Reticulum Cell |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |    2        2        2        2  1  1  2  2  1  2     2  2  2  2  2  2   |             
      Pancreatic, Pigmentation, Hemosiderin|                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2        2        3     4  4  2        2  2  3     2        2        2   |             
      Pigmentation, Hemosiderin            |             2  2     2              1  2  2     2  2     2  2  2     2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 2| 3| 3| 5| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 2| 2| 3| 1| 1| 3| 5| 1| 9| 1| 1| 2| 2| 3| 3| 1| 6| 2| 2| 2| 2| 2| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  4  3  4  2  3  3  2  4  1  2  4  3  2  2     2  2  3  4  3  1  3  3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          X                             X        X        X  X           X|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      White Matter, Degeneration           |                1  1           1  1        1           1  1  1        1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            2                                             |             
      Alveolar Epithelium, Hyperplasia     |                                           2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       2     2  2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |    2  2  2     2  2           2              2  2                 2  2  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                          +              +|             
      Lens, Cataract                       |                               4                          3               |             
      Retina, Atrophy                      |                               4                          4               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +  +           +     +                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |       X     X                                                            |             
      Hydronephrosis                       |       2                                                                  |             
      Inflammation, Chronic Active         |       3     4                                                            |             
      Nephropathy, Chronic                 | 2  2  3  2  2  1     2  2     2  1  2  2  3  1  1  1  2  2  3  2  2  2  2|             
      Renal Tubule, Atrophy                |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 2| 3| 3| 5| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 2| 2| 3| 1| 1| 3| 5| 1| 9| 1| 1| 2| 2| 3| 3| 1| 6| 2| 2| 2| 2| 2| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Transitional Epithelium, Hyperplasia |             3                                                            |             
                                            __________________________________________________________________________|             
   Ureter                                  | +              +                    +     +        +     +     +        +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |             X                                                            |             
      Transitional Epithelium, Hyperplasia |       3     4                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 1| 3| 0| 0| 2| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 8| 1| 1| 2| 1| 3| 1| 3| 3| 8| 2| 1| 8| 3| 2| 2| 2| 9| 2| 3| 2| 1| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                  X                                       |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                   X                                                      |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Diverticulum                         |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  A  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X  X  X  X     X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X|     40     |
      Clear Cell Focus                     |                                                          X               |      1     |
      Hepatodiaphragmatic Nodule           | X  X                                               X                     |      6     |
      Inflammation, Chronic                |             2  1  3  2  2              2        2           2     1     2|     27  1.6|
      Inflammation, Necrotizing            |             2                 2              2                           |      4  1.8|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |                      2                                                   |      2  2.5|
      Portal Vein, Necrosis, Fibrinoid     |                                     2                                    |      1  2.0|
      Portal Vein, Intima, Proliferation   |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                         1  2  2                    2           4         |      6  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                 4                        |      2  3.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pulmonary Artery, Mineralization     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 1| 3| 0| 0| 2| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 8| 1| 1| 2| 1| 3| 1| 3| 3| 8| 2| 1| 8| 3| 2| 2| 2| 9| 2| 3| 2| 1| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy, Chronic              | 2  2  2  2  3  1  2  2  3  3  2  3  2  2  2  3  2  1  2  2  2  2  2  2  2|     47  2.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Cyst                                 |                                     X                                    |      1     |
      Degeneration, Fatty                  |                2                             1                           |     10  1.7|
      Hyperplasia                          |          2        1                 2        1                           |     13  2.0|
      Hypertrophy                          |                                                                3         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             2                                               3            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M  +  M  +  +  M  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +|  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |    X     X     X     X  X           X                                   X|     14     |
      Pars Distalis, Hyperplasia           |    3     2     1     3                                         2        2|     11  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    3           1           2  2  1                                2     2|     20  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |             2                                                        2   |      2  2.0|
      Duct, Dilatation                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     X                          X  X  X   |      4     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +  +           +  +  +     +     +  +  +  +  +  +  +        +     +  +  +|  34        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                    4        3     3     3|      6  3.3|
      Inflammation, Chronic Active         |                                                                   3      |      1  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                  4        1                              |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 1| 3| 0| 0| 2| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 8| 1| 1| 2| 1| 3| 1| 3| 3| 8| 2| 1| 8| 3| 2| 2| 2| 9| 2| 3| 2| 1| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Femoral, Hyperplasia, Reticulum Cell |                   2  2  2                                         2     2|      5  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |    2  2  2  2  2  2  2  2  2  2  2     2     2  2  2  2  2     2  3  2  2|     37  1.9|
      Pancreatic, Pigmentation, Hemosiderin|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M|   3        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |       2  2     3  2     2  2                    2  2  2     2  2  2  2  2|     26  2.3|
      Pigmentation, Hemosiderin            |       2  2     2  2  3  2  2     2     2  2     2  2  2  3  2  2  2  2  2|     31  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  M  +  M  +  +  +  +  M  +  M  M  +  +  M  +  +  +  M  +  +|  38        |
      Cyst                                 |    X                                                                    X|      2     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Cystic                  | 3  2  2  3  3  2  3  2  3  4  4  4     2  4  3  4  2  4  2  2  3  2  3  2|     48  2.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |       X     X              X        X  X     X  X     X                  |     14     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      White Matter, Degeneration           |       1  1                       1  1        1              1  1  1     1|     18  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         | 2        1                 2           2     2              2     2  2  2|     20  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 1| 3| 0| 0| 2| 3| 3| 3| 3| 3| 3|            |
                                           | 6| 8| 1| 1| 2| 1| 3| 1| 3| 3| 8| 2| 1| 8| 3| 2| 2| 2| 9| 2| 3| 2| 1| 2| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                       +                                                |   5        |
      Lens, Cataract                       |                                                                          |      2  3.5|
      Retina, Atrophy                      |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +        +  +        +  +     +                     |  10        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Micro Observation Only      |                                                                          |      2     |
      Hydronephrosis                       |                                                 4                        |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
      Nephropathy, Chronic                 | 2  1  2  2  4  2  1  2  2  2  1  2  2  2  2  1  4  2  1  2  1  2  2  2  1|     48  1.9|
      Renal Tubule, Atrophy                |                                                                          |      1  4.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |          +                    +  +        +  +  +        +  +        +   |  17        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Transitional Epithelium, Hyperplasia |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 4| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 1| 3| 2| 3| 3| 3| 4| 3| 1| 3| 3| 3| 8| 7| 1| 6| 6| 3| 5| 3| 2| 3| 9|             
                                           | 3| 1| 5| 2| 3| 3| 1| 1| 9| 3| 2| 2| 2| 3| 8| 5| 1| 8| 8| 3| 8| 2| 6| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +           +     +              +              +           +|             
      Foreign Body                         |                               3                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          A  +           +     +              +              +           +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +  +           +     +              +              +           +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Liver                                   |          +  +           +     +     +        +  +  +        +           +|             
      Basophilic Focus                     |          X  X                                X  X           X            |             
      Hepatodiaphragmatic Nodule           |                                     X              X                     |             
      Inflammation, Chronic                |                         2     1              1  1  1        2            |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +           +     +              +              +           +|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +  +           +     +     +        +              +           +|             
      Acinus, Atrophy                      |                                     1                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Stomach                                 |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +  +           +     +              +              +           +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +  +           +     +              +              +           +|             
      Inflammation, Chronic Active         |                                                                         2|             
                                            __________________________________________________________________________|             
   Tooth                                   |          +  +           +     +              +              +           +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +           +     +              +              +           +|             
      Cardiomyopathy, Chronic              |          2                    2              2                           |             
      Atrium, Thrombosis                   |                                                                          |             
      Valve, Bacterium                     |                                                                          |             
      Valve, Inflammation, Chronic Active  |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 4| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 1| 3| 2| 3| 3| 3| 4| 3| 1| 3| 3| 3| 8| 7| 1| 6| 6| 3| 5| 3| 2| 3| 9|             
                                           | 3| 1| 5| 2| 3| 3| 1| 1| 9| 3| 2| 2| 2| 3| 8| 5| 1| 8| 8| 3| 8| 2| 6| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Degeneration, Fatty                  | 2  1  2     2        1        2     1  2              3  2           2   |             
      Hyperplasia                          | 2              1     1     1  2     2     1     2              2     3   |             
      Hypertrophy                          |                1           1  4                 2     1                  |             
      Infiltration Cellular, Lymphocyte    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                    1     2                                1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +     +  +  +  +  +  +     +  +  +     +  +  +  +        +  +|             
      Pars Distalis, Cyst                  |             X                    X     X                                 |             
      Pars Distalis, Hyperplasia           |                                  2     2                 2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +  +           +     +              +              +           +|             
      C-Cell, Hyperplasia                  |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |          +  +           +     +  +           +              +           +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |          +  +           +     +              +              +           +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                              +                          +|             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +           +     +              +              +        +  +|             
      Diverticulum                         |                                                                      4   |             
      Inflammation, Chronic Active         |                                                                      3   |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +  +           +     +              +              +           +|             
      Femoral, Hyperplasia, Reticulum Cell |                         2                    2                           |             
      Femoral, Myelofibrosis               |                                                                          |             
      Femoral, Myeloid Cell, Hyperplasia   |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +           +     +     +        +  +           +           +|             
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Necrotizing                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          M  M           M     M              M              M           +|             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +           +     +              +  +           +           +|             
      Fibrosis                             |                                                 2                        |             
      Hematopoietic Cell Proliferation     |             3                                                            |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +  +           +     +              +              +           +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 4| 7| 7| 7| 2|             
                             DAY ON TEST   | 3| 3| 1| 3| 2| 3| 3| 3| 4| 3| 1| 3| 3| 3| 8| 7| 1| 6| 6| 3| 5| 3| 2| 3| 9|             
                                           | 3| 1| 5| 2| 3| 3| 1| 1| 9| 3| 2| 2| 2| 3| 8| 5| 1| 8| 8| 3| 8| 2| 6| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +           +     +              +        +     +  +        +|             
      Hyperplasia, Cystic                  |          2  3           1     2              1        4     1           1|             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +           +     +              +              +  +        +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +  +           +     +              +              +           +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +  +           +     +              +              +           +|             
      Compression                          |                         X                                                |             
      Hydrocephalus                        |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |          +  M           +     M              +              M           +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +  +           +     +              +              +           +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +  +           +     +              +              +           +|             
      Granuloma                            |          1  1           1                    2              1           1|             
      Pigmentation, Hemosiderin            |          1                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    |          +  +           +     +              +              +           +|             
                                            __________________________________________________________________________|             
   Trachea                                 |          +  +           +     +              +              +           +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                         +  +                        |             
      Lens, Cataract                       |    2                                         4                           |             
      Retina, Atrophy                      |                                              4                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +  M           +     +              +              M           M|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +  +           +     +              +              +           +|             
      Bacterium                            |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nephropathy, Chronic                 |          1              1     1              1              1            |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                              +                          +|             
                                            __________________________________________________________________________|             
   Urethra                                 |                         +     +                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +  +           +     +              +              +           +|             
      Dilatation                           |                                                                         4|             
      Inflammation, Chronic Active         |                                                                         2|             
      Transitional Epithelium, Hyperplasia |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 5| 4| 7| 7| 5| 7| 1| 6| 6| 6| 7| 7| 7| 6| 5| 5| 4| 7| 7| 6| 5|            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 4| 3| 3| 5| 3| 1| 2| 8| 4| 3| 3| 3| 6| 7| 0| 4| 3| 3| 4| 9|            |
                                           | 8| 3| 1| 6| 5| 3| 3| 3| 0| 2| 9| 6| 4| 1| 1| 1| 3| 7| 5| 8| 3| 2| 2| 4| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +  +        +     +  +                    +  +  +           +|  16        |
      Foreign Body                         |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +  +        +     +  +              +     +  +  +           +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +  +        +     A  +                    +  +  +           +|  14        |
      Parasite Metazoan                    |                                                          X               |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +  +        +     +  +                    +  +  +           +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +  +        +     A  +              +     +  +  +           +|  16        |
      Parasite Metazoan                    |                                                             X            |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +  +        +     +  +                    +  +  +           +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +  +        +     +  +                    +  +  +           +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +  +        +     +  +                    +  +  +           +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +  +        +     +  +                    +  +  +           +|  16        |
                                            __________________________________________________________________________|____________|
   Liver                                   |             +  +        +     +  +  +              +  +  +  +           +|  21        |
      Basophilic Focus                     |                                                       X     X            |      7     |
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation, Chronic                |                                                       2                  |      7  1.4|
      Vacuolization Cytoplasmic            |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +           +  +        +     +  +                 +  +  +  +           +|  18        |
      Inflammation, Chronic Active         | 3                                                  4                     |      2  3.5|
      Necrosis                             | 3                                                  3                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +  +        +     +  +                    +  +  +           +|  17        |
      Acinus, Atrophy                      |                         1                                                |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +  +        +     +  +                    +  +  +           +|  16        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +  +        +     +  +                    +  +  +           +|  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +  +        +     +  +                    +  +  +           +|  16        |
      Inflammation, Chronic Active         |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +  +        +     +  +                    +  +  +           +|  16        |
      Inflammation, Chronic Active         |             3                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +  +        +     +  +                    +  +  +           +|  16        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +  +        +     +  +                    +  +  +           +|  16        |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +  +        +     +  +                    +  +  +           +|  16        |
      Cardiomyopathy, Chronic              |             2           2                             2  3               |      7  2.1|
      Atrium, Thrombosis                   |                                  X                                       |      1     |
      Valve, Bacterium                     |                                  X                                       |      1     |
      Valve, Inflammation, Chronic Active  |                                  3                                       |      1  3.0|
      Valve, Thrombosis                    |                                  X                                       |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 5| 4| 7| 7| 5| 7| 1| 6| 6| 6| 7| 7| 7| 6| 5| 5| 4| 7| 7| 6| 5|            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 4| 3| 3| 5| 3| 1| 2| 8| 4| 3| 3| 3| 6| 7| 0| 4| 3| 3| 4| 9|            |
                                           | 8| 3| 1| 6| 5| 3| 3| 3| 0| 2| 9| 6| 4| 1| 1| 1| 3| 7| 5| 8| 3| 2| 2| 4| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Inflammation, Chronic       |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  | 2        1        1        3              2                       2      |     17  1.8|
      Hyperplasia                          |    1              2                       2     2              1  2      |     16  1.7|
      Hypertrophy                          |                                                                          |      5  1.8|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                     1                                    |      5  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +  +        +     +  +                    +  +  +           +|  16        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +  +        +     +  +                    +  +  M           +|  15        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +     +     +  +  +     +     +  +  +  +  +  +  +  +  +|  40        |
      Pars Distalis, Cyst                  |    X  X     X     X     X                          X                    X|     10     |
      Pars Distalis, Hyperplasia           | 3  2  3                                         2  2        2  3  2      |     11  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +  +        +     +  +              +     +  +  +           +|  17        |
      C-Cell, Hyperplasia                  |             1                                                           2|      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |             +  +        +     +  +                    +  +  +           +|  17        |
      Inflammation, Chronic Active         |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +  +  +     +  +  +  +  +  +                 +  +  +           +|  20        |
      Cyst                                 |                      X     X        X                                   X|      4     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                  +                                      +|   4        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |             +  +        +     +  +                    +  +  +           +|  19        |
      Diverticulum                         |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                          3               |      2  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +  +        +     +  +                    +  +  +           +|  16        |
      Femoral, Hyperplasia, Reticulum Cell |                                                             1            |      3  1.7|
      Femoral, Myelofibrosis               |                         2                                                |      1  2.0|
      Femoral, Myeloid Cell, Hyperplasia   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 5| 4| 7| 7| 5| 7| 1| 6| 6| 6| 7| 7| 7| 6| 5| 5| 4| 7| 7| 6| 5|            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 4| 3| 3| 5| 3| 1| 2| 8| 4| 3| 3| 3| 6| 7| 0| 4| 3| 3| 4| 9|            |
                                           | 8| 3| 1| 6| 5| 3| 3| 3| 0| 2| 9| 6| 4| 1| 1| 1| 3| 7| 5| 8| 3| 2| 2| 4| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +  +        +     +  +  +                 +  +  +        +  +|  21        |
      Mandibular, Hyperplasia, Plasma Cell |                                                                      2   |      1  2.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Necrotizing                      |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +           M  M        M     +  M                    M  +  M           M|   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +  +        +     +  +  +  +           +  +  +  +           +|  22        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |             3                                                            |      2  3.0|
      Thrombosis                           |                                                          X               |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +  +        +     +  +                    +  +  +           +|  16        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +        +  +  +  +     +     +  +  +              +  +  +  +           +|  24        |
      Hyperplasia, Cystic                  |             3  1        3     1  2                 4  2  3  2           3|     18  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +           +  +  +     +     +  +  +  +           +  +  +  +        +  +|  24        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +  +        +     +  +                    +  +  +           +|  16        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +  +        +     +  +                    +  +  +           +|  16        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +  +        +     +  +                    +  +  +           +|  16        |
      Compression                          |                                  X                    X  X               |      4     |
      Hydrocephalus                        |                                                       3  2               |      2  2.5|
      Inflammation, Chronic Active         |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |             +  +        +     +  +                    +  +  +           M|  12        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |             +  +        +     +  +                    +  +  +           +|  16        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |             +  +        +     +  +  +                 +  +  +           +|  17        |
      Granuloma                            |                                                             2            |      7  1.3|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |             +  +        +     +  +                    +  +  +           +|  16        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +  +        +     +  +                    +  +  +           +|  16        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                          +                     |   5        |
      Lens, Cataract                       |                                                                          |      2  3.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 5| 4| 7| 7| 5| 7| 1| 6| 6| 6| 7| 7| 7| 6| 5| 5| 4| 7| 7| 6| 5|            |
                             DAY ON TEST   | 9| 3| 3| 5| 3| 4| 3| 3| 5| 3| 1| 2| 8| 4| 3| 3| 3| 6| 7| 0| 4| 3| 3| 4| 9|            |
                                           | 8| 3| 1| 6| 5| 3| 3| 3| 0| 2| 9| 6| 4| 1| 1| 1| 3| 7| 5| 8| 3| 2| 2| 4| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             M  M        I     +  +                    M  +  M           +|   8        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |             +  +        +     +  +                    +  +  +     +     +|  17        |
      Bacterium                            |                                  X                                       |      1     |
      Infarct                              |                                                       4                  |      1  4.0|
      Inflammation, Chronic Active         |                                  2                                       |      1  2.0|
      Nephropathy, Chronic                 |             3                    2                    3  1        3     1|     11  1.6|
      Pigmentation, Hemosiderin            |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |             +                                            +               |   4        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             M  +        +     +  +                    M  +  +           +|  14        |
      Dilatation                           |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 5| 7| 6| 7| 7| 5| 7| 6| 6| 7| 3|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 5| 1| 3| 1| 3| 4| 5| 1| 3| 7| 1| 5| 3| 3| 9| 3| 6| 8| 3| 8|             
                                           | 8| 2| 1| 3| 1| 5| 5| 2| 7| 3| 3| 2| 1| 1| 8| 2| 2| 3| 2| 5| 3| 8| 8| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                4                                                         |             
      Inflammation, Suppurative            |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                             X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X  X  X  X  X  X  X     X  X        X  X           X     X  X  X  X   |             
      Degeneration, Cystic                 |                                     3                                    |             
      Hepatodiaphragmatic Nodule           |                      X                                            X      |             
      Inflammation, Chronic                |       1  2     1  1  1                 1  1        3  2     1  1  2  2   |             
      Necrosis, Coagulative                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                      2        2                                      3  1|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |             3                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1  2  2  2  3  2  1  2  2  3  1     2  2  1  2  2  2  2  2  2  2  2  2  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                         1                                                |             
      Atrium, Thrombosis                   |                                                                          |             
      Valve, Bacterium                     |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 5| 7| 6| 7| 7| 5| 7| 6| 6| 7| 3|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 5| 1| 3| 1| 3| 4| 5| 1| 3| 7| 1| 5| 3| 3| 9| 3| 6| 8| 3| 8|             
                                           | 8| 2| 1| 3| 1| 5| 5| 2| 7| 3| 3| 2| 1| 1| 8| 2| 2| 3| 2| 5| 3| 8| 8| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                   X      |             
      Degeneration, Fatty                  |             2              1                       2  2  2        1  1   |             
      Hyperplasia                          |             2              1        2              2     2     1  2  1   |             
      Hypertrophy                          |       2                    3                                         3   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1     1        1  1                          1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |          X  X                          X     X     X  X  X              X|             
      Pars Distalis, Hyperplasia           |    2        2     3  2                             1                     |             
      Pars Intermedia, Hyperplasia         |                            2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             2                       2  2  1        2           1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                 X   |             
                                            __________________________________________________________________________|             
   Oviduct                                 |    +  +     +           +  +                 +     +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                            3                          2                  |             
      Diverticulum                         |                                                                          |             
      Hemorrhage                           |                   4                                                      |             
      Cervix, Fibrosis                     |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |          2           1           2              1           1     1  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia                 |                                  4                                       |             
      Femoral, Hyperplasia, Reticulum Cell |                   3                                                      |             
      Femoral, Myelofibrosis               |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 5| 7| 6| 7| 7| 5| 7| 6| 6| 7| 3|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 5| 1| 3| 1| 3| 4| 5| 1| 3| 7| 1| 5| 3| 3| 9| 3| 6| 8| 3| 8|             
                                           | 8| 2| 1| 3| 1| 5| 5| 2| 7| 3| 3| 2| 1| 1| 8| 2| 2| 3| 2| 5| 3| 8| 8| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Vertebral, Hyperplasia               |                                  4                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Hyperplasia, Plasma Cell |                                                                         3|             
      Mandibular, Pigmentation, Hemosiderin|                                                                2         |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      | 2  2  2  2  2  2  2        2  2     2  2  2     2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  M  M  M  M  M  M  M  M  M  +  M  M  M  M  +  M  M  +  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2  2     2  4  2  2  2  2     2  2     2        2        2  2  2   |             
      Pigmentation, Hemosiderin            | 2  2  2        2     2  2              2  2        2  2     3  2  2  2  3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +|             
      Cyst                                 |                      X                 X                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 4  2  4  2  2  1  2  3  2  3  2  3  3  2  2  2  2  2  2  2  3  4  2  3  1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |             X                                                            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X  X              X                       X     X     X  X  X      |             
      Hydrocephalus                        |                                           2                 2            |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      White Matter, Degeneration           |                   1  1     1        1                 1     1        1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                           2                              |             
      Inflammation, Chronic Active         |                                              2                           |             
      Alveolar Epithelium, Hyperplasia     |                                        2  3                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2                                                            |             
      Nasolacrimal Duct, Granuloma         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |       2  2           1     2                 2     2  2        2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                  2        1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 5| 7| 6| 7| 7| 5| 7| 6| 6| 7| 3|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 5| 1| 3| 1| 3| 4| 5| 1| 3| 7| 1| 5| 3| 3| 9| 3| 6| 8| 3| 8|             
                                           | 8| 2| 1| 3| 1| 5| 5| 2| 7| 3| 3| 2| 1| 1| 8| 2| 2| 3| 2| 5| 3| 8| 8| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    12 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                       +                 +     +        +     +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                2         |             
      Nephropathy, Chronic                 | 2  1  2  2  4  1  2  2  1  2        2  1  1  1  1  1  2  1  3  1  2  2   |             
                                            __________________________________________________________________________|             
   Ureter                                  | +     +  +  +  +              +     +  +                 +           +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 1| 1| 1| 5| 2| 2| 6| 3| 3| 3| 3| 1| 1| 2| 5| 1| 3| 2| 2| 1| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    12 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |          X                                                              X|      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
      Parasite Metazoan                    |                                                       X                  |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         1                                                |      1  1.0|
      Basophilic Focus                     | X  X  X  X  X  X     X  X  X        X  X  X  X  X     X  X  X  X  X  X  X|     37     |
      Degeneration, Cystic                 |                                                                2         |      2  2.5|
      Hepatodiaphragmatic Nodule           |                   X                          X  X                        |      5     |
      Inflammation, Chronic                | 2  1  1  2     2     1     2  2     1  1        1     2  1  2  2     1   |     29  1.5|
      Necrosis, Coagulative                |                   4                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                        3                                 |      1  3.0|
      Necrosis                             |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |       1     1        1                 1        3                       2|     10  1.7|
      Duct, Ectasia                        |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              | 2  2  2  2  2  2  3  2  2  2  2  1  2  2  2  2  2  2  2  2  2     2  2  2|     48  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 1| 1| 1| 5| 2| 2| 6| 3| 3| 3| 3| 1| 1| 2| 5| 1| 3| 2| 2| 1| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    12 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                   3                                                      |      1  3.0|
      Mineralization                       |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                   X                                                      |      1     |
      Valve, Bacterium                     |                   X                                                      |      1     |
      Valve, Thrombosis                    |                   X                                                      |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Degeneration, Fatty                  |    1  2              1     1        3  2  1           1        1         |     16  1.5|
      Hyperplasia                          |       3  2     2        2  2              2     2     2  2  1            |     18  1.8|
      Hypertrophy                          | 2  1                                1                          2     1   |      8  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                    1                     |      6  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |          2                       2              3                 2  2  2|      6  2.2|
      Pars Distalis, Cyst                  | X  X  X     X  X  X  X        X  X  X     X  X  X  X     X  X        X   |     25     |
      Pars Distalis, Hyperplasia           |             3              2     2                    2        2  2     2|     12  2.1|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 2  1  2        2           2        2  2                 2               |     14  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2                                                               |      1  2.0|
      Inflammation, Chronic Active         |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     X                                    |      3     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +  +  +  +     +  +     +  +     +  +        +  +              +  +     +|  26        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |             3           2  3                       2                     |      6  2.5|
      Diverticulum                         |       4                                                                  |      1  4.0|
      Hemorrhage                           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 1| 1| 1| 5| 2| 2| 6| 3| 3| 3| 3| 1| 1| 2| 5| 1| 3| 2| 2| 1| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    12 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cervix, Fibrosis                     |                               2                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 2                       2  2     2     1           1        1            |     14  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                   +      |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia                 |                                                                          |      1  4.0|
      Femoral, Hyperplasia, Reticulum Cell |                3                                      2                  |      3  2.7|
      Femoral, Myelofibrosis               |                                                                          |      1  2.0|
      Vertebral, Hyperplasia               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |      1  3.0|
      Mandibular, Pigmentation, Hemosiderin|                                                                          |      1  2.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      | 2  2  2     2           2  2  2     2  2  2  2           2  2  2  2     2|     37  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  +  M  M  M  M  M  M  M|   6        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  2        2  3  2        2  2           2  2        3  2   |     32  2.1|
      Pigmentation, Hemosiderin            |    2  2  2  2  2  2  3        2     2  2  2  2  2     2  2  2        2   |     32  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|  41        |
      Cyst                                 |                                        X                             X   |      4     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 4  2  2  3  3  2  4  3  3  2  2  3     3  2     2  2  2  2  2  2  2  2  3|     48  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Fibrous Osteodystrophy        |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |             X        X                 X        X  X                     |     13     |
      Hydrocephalus                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 1| 1| 1| 5| 2| 2| 6| 3| 3| 3| 3| 1| 1| 2| 5| 1| 3| 2| 2| 1| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    12 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      White Matter, Degeneration           |       1              1              1        1                           |     11  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma                            |    2     2     1        2                                                |      5  1.8|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |      3  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Nasolacrimal Duct, Granuloma         | 2                                                                        |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         | 2  2        2  3     2        2  2  2  2     2  2  2                     |     20  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +        +                 +              +              +      |   6        |
      Lens, Cataract                       |          4        4                 4              3              4      |      5  3.8|
      Retina, Atrophy                      |          4                          4                             4      |      3  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +     +        +        +                       +                     |  11        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                   X                                                      |      1     |
      Inflammation, Chronic Active         |                   3                                                      |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy, Chronic                 | 1  1  2  2  2  2     2  2  2  2     2  3  2  2  1     1  3  2  2  1  2  1|     44  1.8|
                                            __________________________________________________________________________|____________|
   Ureter                                  |          +                       +        +  +        +  +           +   |  17        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3|             
                                           | 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  M  +  A  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X           X                                                        X   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 | 3           1              2        1        1                           |             
      Fatty Change                         |                                           4                              |             
      Hepatodiaphragmatic Nodule           |                         X                                                |             
      Inflammation, Chronic                |             1                                            2               |             
      Inflammation, Necrotizing            |                                           4                              |             
      Mineralization                       |                                  2                                       |             
      Necrosis, Coagulative                |                                  4                                       |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      | 2                    2           2  2                          4     2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         3                 2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                                           4                              |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric Artery, Mineralization    |                                                                          |             
      Mesenteric Artery, Intima,           |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  3  2  2  3  2  2  3     2  2  2  2  2  2  3  3  2  2  2  2  1  2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3|             
                                           | 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Infarct                              |                                                                          |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                         3                 3        1  1                  |             
      Hyperplasia                          |    2                                            2                       2|             
      Hypertrophy                          | 2                                                                        |             
      Necrosis, Coagulative                |                         2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                                |             
      Hyperplasia                          |       2     2     2                          3                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                       X           X      |             
      Pars Distalis, Hyperplasia           |    2  2  2        2     2  1     2  2                                1  2|             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pars Intermedia, Cyst                |                               X                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2                                                                        |             
      C-Cell, Hyperplasia                  |    1              2                                      2  1  2         |             
      Follicular Cell, Hyperplasia         | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +|             
      Inflammation, Chronic Active         |                      2                       2                           |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         | +     +     +           +     +     +     +  +                           |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                       +                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |    2        2  2  2  2     2  2  2  2  2  2  4     2     2  1  2  2  2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic Active         | 3  1     2  2  2     4  2  2     3     4  2        3  2  2  2        2   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +     +  +     +        +  +  +  +           +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3|             
                                           | 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2  2  2  1           1  1                       1     1     1  1        1|             
      Interstitial Cell, Hyperplasia       |                2  2     2  1     1                 2  2     1  1         |             
      Seminiferous Tubule, Atrophy         | 3  4  4  4     3  3     4  2  4  2  4  3     4  3     3     2  4  4  4  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia                 |                            3                                             |             
      Femoral, Hyperplasia, Reticulum Cell |                      2                                                   |             
      Vertebral, Hyperplasia               |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Pigmentation, Hemosiderin |                                                                   2      |             
      Mandibular, Cyst                     |                                              X                       X   |             
      Mandibular, Hyperplasia, Plasma Cell |             3  3     2                                                   |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                  3                                       |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Renal, Hemorrhage                    |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  M  M  M  M  +  M  M  +  M  +  M  M  +  M  +  M  M  M  M  M  M|             
      Hemorrhage                           |                                  2                                       |             
      Infiltration Cellular, Histiocyte    |                                                 3                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 4                                                                        |             
      Hematopoietic Cell Proliferation     |       2  3        2        4  1  2        2  2  1                    2  3|             
      Infiltration Cellular, Lipocyte      | 2                                                                        |             
      Necrosis, Coagulative                |                         2                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  M  +  +  +  +  M  +  M  +  +  +  M  +  +  +  M  +  +  +  +  M|             
      Hyperplasia, Cystic                  | 4  1  1        2  3  2  2     4     2  2  3     1  4  2     4  3  1  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      |                                                                          |             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
      Vertebra, Fibrous Osteodystrophy     |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3|             
                                           | 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X                    X                 X                                 |             
      Hemorrhage                           |                                        2                    2  3         |             
      Hydrocephalus                        |                                        4                 3               |             
      Inflammation, Chronic                |                                        2                                 |             
      Pigmentation, Hemosiderin            |                                        2                                 |             
      White Matter, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                2         |             
      White Matter, Degeneration           |             1     1                          2                    2  2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          3        2                                                      |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Adenomatous                     |                                                                3         |             
      Artery, Mediastinum, Necrosis,       |                                                                          |             
          Fibrinoid                        |                                                 2                        |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                 4                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  2  3                                    |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                 4                    3  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                         3                                         1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 I                        |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +        +  +           +     +               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X        X                    X                          X|             
      Hydronephrosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3|             
                                           | 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                2                                                         |             
      Nephropathy, Chronic                 | 3  2  3  2  4  4  3  4  2  4  3  2  3  3  4  4  4  3  2  3  4  4  3  4  2|             
                                            __________________________________________________________________________|             
   Ureter                                  | +     +  +     +     +  +     +  +  +  +     +  +  +  +  +           +   |             
                                            __________________________________________________________________________|             
   Urethra                                 | +  +     +        +              +              +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      2                                                   |             
      Transitional Epithelium, Hyperplasia |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3|            |
                                           | 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Necrotizing            |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |       X  X                                            X                  |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                X                                X                       X|      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                  X     X     X  X                        |      7     |
      Clear Cell Focus                     |                                                                   X      |      1     |
      Degeneration, Cystic                 |                                        2           2  1           1  2   |     10  1.6|
      Fatty Change                         |                                                             2            |      2  3.0|
      Hepatodiaphragmatic Nodule           |                                                                      X   |      2     |
      Inflammation, Chronic                | 1                                                                        |      3  1.3|
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                         2                                                |      2  3.0|
      Vacuolization Cytoplasmic            |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
      Acinus, Atrophy                      |          1     1  1     2              2  1  1           2           1   |     15  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                     2                                    |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3|            |
                                           | 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Mesenteric Artery, Mineralization    |                                     2                                    |      1  2.0|
      Mesenteric Artery, Intima,           |                                                                          |            |
          Proliferation                    |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              | 3  2  2  3  2  2  2  2  2  2  3  2  3  2  2  2  2  2     2  2  2  3  2  2|     48  2.2|
      Infarct                              |                            4                                             |      1  4.0|
      Mineralization                       |                                     3  1                          1      |      3  1.7|
      Atrium, Thrombosis                   |                                                 X     X                  |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  |                         1     1                       2     2            |      8  1.8|
      Hyperplasia                          |                   1        2  2        2     3              2     2      |     10  2.0|
      Hypertrophy                          |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |       2     1     2     2                       1     2     2  2  2      |     13  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |             X                                                  X         |      4     |
      Pars Distalis, Hyperplasia           |                   2  2        2           2     1              2  2  2   |     18  1.8|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                    1                     |      1  1.0|
      Pars Intermedia, Cyst                |                            X                                             |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |                2                             2        2              1   |      9  1.7|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       | +  +           +  +        +  +  +  +  +  +  +     +     +  +           +|  36        |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3|            |
                                           | 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |    +     +           +  +                       +                    +  +|  15        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |          +                    +                                          |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 4                                                                        |      1  4.0|
      Inflammation, Chronic Active         | 1  1  1  2  2  1     2  1     1  1  2  2  1  2  2  1  1  2  2  4  1  2  2|     42  1.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |       4                                                                  |      1  4.0|
      Inflammation, Chronic Active         |    2              2     2  1  2  2  2        2     1     2  1        2  2|     29  2.1|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +     +  +  +        +  +  +     +  +  +  +  +  +  +  +  +  +     +|  35        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                   1  2  1     1     1              1                     |     17  1.2|
      Interstitial Cell, Hyperplasia       |    2  2  2     2     1  1     2     2     1        1  1  1  1  2     2  1|     25  1.5|
      Seminiferous Tubule, Atrophy         | 4     4  4  4  4  4  4     4  4  4  4  4     4  4  4  4  4     4  4  2   |     40  3.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia                 |                                                                          |      1  3.0|
      Femoral, Hyperplasia, Reticulum Cell |                                                                          |      1  2.0|
      Vertebral, Hyperplasia               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bronchial, Pigmentation, Hemosiderin |       1                                2                                 |      3  1.7|
      Mandibular, Cyst                     |                            X     X                                       |      4     |
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |      3  2.7|
      Mediastinal, Hemorrhage              |                         4                                                |      1  4.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |             2                                                            |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  M  M  M  M  M  M  +  M  M  M  +  M  M  M  M  +  M  +  +  +  M  +  M|  15        |
      Hemorrhage                           |                         3                                                |      2  2.5|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 1        2     2                                                        2|      5  2.2|
      Hematopoietic Cell Proliferation     |       2           2  1           2  2        2              2            |     18  2.1|
      Infiltration Cellular, Lipocyte      |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3|            |
                                           | 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  M  +  M  +  +  +  +  M  M  +  +  +  +  +  M  M  M  +  +  M|  37        |
      Cyst                                 |                   X           X                                   X      |      3     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +     M  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +|  37        |
      Hyperplasia, Cystic                  | 2  2  1     2  1  1  2        2  2  2     1  2  2  2  2  1        1  2  2|     37  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                   2      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Fibrous Osteodystrophy      |                                     X                                    |      1     |
      Femur, Fibrous Osteodystrophy        |                                     X                                    |      1     |
      Vertebra, Fibrous Osteodystrophy     |                                     X                                    |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|  48        |
      Compression                          |                                                             X            |      4     |
      Hemorrhage                           |                                                                          |      3  2.3|
      Hydrocephalus                        |                                                                          |      2  3.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      White Matter, Degeneration           |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | M  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  M  +  M  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Acute                    |                                                                          |      1  2.0|
      White Matter, Degeneration           | 2     2  1     1           1        1  1     2  1     1  1  1     1     1|     19  1.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                     3  1                                 |      4  2.3|
      Mineralization                       |                                     2                                    |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Adenomatous                     |                2                                                  2      |      3  2.3|
      Artery, Mediastinum, Necrosis,       |                                                                          |            |
          Fibrinoid                        |                                                                          |      1  2.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3|            |
                                           | 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                     2                       2            |      4  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |       2  2     2  2        2                 2  2     1     3  1  2     1|     15  2.1|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                  2                 2                     |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                    +                                      +   |   3        |
      Lens, Cataract                       |                               3                                          |      1  3.0|
      Retina, Atrophy                      |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +           +                                      +   |   8        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        X                    X            |      6     |
      Hydronephrosis                       | 4                                                                        |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy, Chronic                 | 3  2  3  4  3  3  4  4  2  4  3  4  4  4  2  4  3  3  3  4  4  4  4  3  4|     50  3.3|
                                            __________________________________________________________________________|____________|
   Ureter                                  |    +  +  +  +  +  +  +  +  +  +  +     +  +        +  +  +  +     +  +   |  35        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |       +  +           +  +     +                                   +  +   |  18        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 5| 7| 6| 5| 4| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 4| 5| 3| 3| 6| 3| 9| 7| 2| 0| 2| 1| 4| 1| 3| 3| 9| 7| 3| 7| 3| 3| 3| 0|             
                                           | 3| 9| 5| 2| 2| 1| 2| 5| 5| 1| 0| 2| 5| 1| 5| 2| 2| 0| 6| 1| 7| 1| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +        +        +  +  +     +     +                             +|             
      Foreign Body                         |                3                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +        A        +  +  +     +     +                             +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +        A        +  +  +     +     +                             A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +        A        +  +  +     +     +                             A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +        A        +  +  +     +     +                             +|             
      Inflammation, Chronic Active         |                                                                         4|             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +        A        +  +  +     +     +                             A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +        A        +  +  +     +     +                             A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +        A        +  +  +     +     +                             A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +        A        +  +  +     +     +                             A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X                                   X           X     X     X   |             
      Clear Cell Focus                     |                                           X                              |             
      Degeneration, Cystic                 |             3                 2        1                 2           2   |             
      Hepatodiaphragmatic Nodule           |                                                                         X|             
      Inflammation, Chronic                |                               1              2                    2      |             
      Leukocytosis                         |                                                    X                     |             
      Necrosis, Coagulative                |                                                                         3|             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +                 +  +  +     +     +                             +|             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +        A  +     +  +  +  +  +     +                       +     A|             
      Cyst                                 |                   X                                                      |             
      Acinus, Atrophy                      |    2              3     2     1     2     1                              |             
      Artery, Inflammation, Proliferative  |                   3              4                                3      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +        +        +  +  +     +     +                             +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +        A        +  +  +     +     +                             +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +        A        +  +  +     +     +                             +|             
      Inflammation, Chronic Active         |                            4                                             |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +        A        +  +  +     +     +                             A|             
                                            __________________________________________________________________________|             
   Tooth                                   |    +  +        +        +  +  +     +     +                             +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +        +        +  +  +     +     +                             +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +        +     +  +  +  +     +     +           +                 +|             
      Cardiomyopathy, Chronic              |    2  2        2     2        2     2     3                             3|             
      Atrium, Thrombosis                   |                      X                                X                 X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 2  2                                   2              2     2     1  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 5| 7| 6| 5| 4| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 4| 5| 3| 3| 6| 3| 9| 7| 2| 0| 2| 1| 4| 1| 3| 3| 9| 7| 3| 7| 3| 3| 3| 0|             
                                           | 3| 9| 5| 2| 2| 1| 2| 5| 5| 1| 0| 2| 5| 1| 5| 2| 2| 0| 6| 1| 7| 1| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |    2                                1        2                    2  2   |             
      Hypertrophy                          | 2                                                     2                  |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | X                                                                        |             
      Hyperplasia                          | 3     1                       2  2     1     2        3  2  1  1  2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +        A        +  +  +     +     +                             A|             
      Vacuolization Cytoplasmic            |                                           2                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +        +        +  +  +     M     +                             +|             
      Hyperplasia                          |                               3                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    M  M        +     +  +  +  +  +  M  +  +              +  +  +  +     I|             
      Pars Distalis, Cyst                  |                      X                                                   |             
      Pars Distalis, Hyperplasia           |                                                          2     3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +        A     +  +  +  +     +     +              +              A|             
      C-Cell, Hyperplasia                  |    1  1                             2                                    |             
      Follicular Cell, Hyperplasia         |    1  1                 1     1     1                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |    +  +        +        +     +     +                                    |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |       +        +        +  +                                             |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +        +        +  +  +     +     +                             +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +        +        +  +  +     +     +                             +|             
      Inflammation, Chronic Active         |    2  2        1        2  2  2     2     2                             2|             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +        +        +  +  +  +  +     +                             +|             
      Inflammation, Chronic Active         |    3           3        2  2     3  2     4                             4|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +           +        +     +     +     +        +                     |             
      Inflammation, Chronic Active         |                                           4                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +|             
      Hyperplasia                          |                                                 1  1                     |             
      Mineralization                       |                   1              1  1        1           1     1         |             
      Interstitial Cell, Hyperplasia       | 1  2  1  2  2           2     2  2  1  2                             1   |             
      Perivascular, Atrophy                |                                                                          |             
      Rete Testes, Hyperplasia             |                      2                                                   |             
      Seminiferous Tubule, Atrophy         | 4  3  3  4  4     4  4  1  4  2  4  2        4  4  4     4     4  4  4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +        +        +  +  +     +     +                             +|             
      Femoral, Myelofibrosis               |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +     +  +  +  +  +  +  +  +                       +     +|             
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 5| 7| 6| 5| 4| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 4| 5| 3| 3| 6| 3| 9| 7| 2| 0| 2| 1| 4| 1| 3| 3| 9| 7| 3| 7| 3| 3| 3| 0|             
                                           | 3| 9| 5| 2| 2| 1| 2| 5| 5| 1| 0| 2| 5| 1| 5| 2| 2| 0| 6| 1| 7| 1| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                         4|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    M  M     +  M     +  +  M  M  +  M  +  M                       +     M|             
      Cyst                                 |                                                                   X      |             
      Inflammation, Proliferative          |                                  4                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Fibrosis                             |          2                    2        1     1                           |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +        +        +  M  +     +     +                             +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +        +        M  +  M     +     M                             +|             
      Hyperplasia, Cystic                  |    2  2        3           4        1                                    |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +        +        +  +  +     +     +                 +  +        +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic Active         |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +        +        +  +  +     +     +                             +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +  +        +        +  +  +     +     +                             +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +        +        +  +  +     +     +                             +|             
      Compression                          |                            X              X                              |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                            2              2                              |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +  +        +        +  M  +     +     +                             +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +  +        +        +  +  +     +     +                             A|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +        +        +  +  +     +     +                             +|             
      Bacterium                            |                                                                         X|             
      Granuloma                            |                            2              2                              |             
      Inflammation, Chronic Active         |                               2                                         4|             
      Metaplasia, Osseous                  |                               1                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Adenomatous                     |                               2                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +        +        +  +  +     +     +                             +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                         2|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +        A        +  +  +     +     +                             +|             
      Inflammation, Chronic Active         |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 5| 7| 6| 5| 4| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 4| 5| 3| 3| 6| 3| 9| 7| 2| 0| 2| 1| 4| 1| 3| 3| 9| 7| 3| 7| 3| 3| 3| 0|             
                                           | 3| 9| 5| 2| 2| 1| 2| 5| 5| 1| 0| 2| 5| 1| 5| 2| 2| 0| 6| 1| 7| 1| 2| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                 +        +                                    |             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |                            2                                             |             
      Retina, Atrophy                      |          4                 4                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +        M        +  +  +     M     +                             M|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  A     +  +  +  +  +  +     +        +  +        +  +  +  +|             
      Cyst                                 |          X                    X                                   X      |             
      Inflammation, Chronic                |                                                                          |             
      Nephropathy, Chronic                 | 4  1  2  4  4        4  3  2  4  4  3     3        4  4        4  4  4  1|             
                                            __________________________________________________________________________|             
   Ureter                                  |    +  +        A        +  +  +     +                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +        A        +  +  +     +     +        +                    +|             
      Inflammation, Chronic Active         |                                           4        2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 6| 5| 6| 3| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 0| 0| 3| 0| 9| 4| 7| 2| 3| 3| 8| 0| 3| 3| 3| 9| 9| 3| 3| 9| 3| 3|            |
                                           | 6| 1| 3| 8| 8| 3| 0| 6| 1| 9| 6| 1| 2| 4| 9| 2| 2| 3| 6| 2| 2| 1| 7| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +     +  +     +              +           +  +               |  16        |
      Foreign Body                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +     +  +     +              +           +  +               |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +     +  +     +              +           A  A               |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +     +  +     +              +           +  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +     +  +     +              +           +  +               |  15        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +     +  +     +              +           +  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +     +  +     +              +           +  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +     +  +     +              +           +  +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +     +  +     +              +           +  +               |  14        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X           X                 X              X  X           X     X  X|     14     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |    2                             2                          1            |      8  1.9|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inflammation, Chronic                | 1                          1                       1           1         |      7  1.3|
      Leukocytosis                         |                                                                          |      1     |
      Necrosis, Coagulative                |                                                          3               |      2  3.0|
      Vacuolization Cytoplasmic            |                1     3  3                       2                        |      4  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +     +  +  +  +              +           +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +     +  +     +              +           +  +               |  17        |
      Cyst                                 |                                                                          |      1     |
      Acinus, Atrophy                      |             1     1                                   3                  |      9  1.8|
      Artery, Inflammation, Proliferative  |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +     +  +     +              +           M  +               |  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +     +  +     +              +           +  +               |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +     +  +     +              +           +  +               |  15        |
      Inflammation, Chronic Active         |                      3                                                   |      2  3.5|
      Epithelium, Hyperplasia              |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +     +  +     +              +           +  +               |  14        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +     +  +     +              +           +  +               |  16        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +     +  +     +              +           +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +     +  +  +  +              +     +     +  +        +      |  21        |
      Cardiomyopathy, Chronic              |             2     2  2  2                 2     2     2  2               |     16  2.1|
      Atrium, Thrombosis                   |                         X                                X        X      |      6     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 6| 5| 6| 3| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 0| 0| 3| 0| 9| 4| 7| 2| 3| 3| 8| 0| 3| 3| 3| 9| 9| 3| 3| 9| 3| 3|            |
                                           | 6| 1| 3| 8| 8| 3| 0| 6| 1| 9| 6| 1| 2| 4| 9| 2| 2| 3| 6| 2| 2| 1| 7| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  | 2              1     2                 1           2                     |     12  1.8|
      Hyperplasia                          |                2                             2  2  2           2         |     10  1.9|
      Hypertrophy                          |                                                                          |      2  2.0|
      Mineralization                       |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular                      |                                                                          |      1     |
      Hyperplasia                          | 2        2     2        2        2  1        3  2  2        2     2  2  2|     24  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +     +  +     +              +           +  +               |  14        |
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +     +  +     +              +           M  +               |  14        |
      Hyperplasia                          |                      2                                                   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +     +  +     +              +           +  +           +  +|  23        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                                         3|      3  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +        +     +  +     +              +           M  +     +         |  17        |
      C-Cell, Hyperplasia                  |                            2              2                              |      5  1.6|
      Follicular Cell, Hyperplasia         |             1        1                                                   |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |             +     +  +     +              +           +  +               |  13        |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |             +                             +                              |   6        |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +     +  +     +              +           +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +     +  +     +  +           +           +  +               |  17        |
      Inflammation, Chronic Active         |             2     2  2     2  2           2           1                  |     16  1.9|
                                            __________________________________________________________________________|____________|
   Prostate                                |          +  +     +  +     +        +     +           +  +               |  19        |
      Inflammation, Chronic Active         |          4  3        2              3     2           2                  |     14  2.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +  +     +  +     +        +     +           +  +               |  16        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      2  1.0|
      Mineralization                       |    1  1  1     1  1     1        1  1  1     1  1     1           1      |     19  1.0|
      Interstitial Cell, Hyperplasia       |       1  1  2     2  1  2  1     2  2  2  1  1     1        1     2  1  1|     28  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 6| 5| 6| 3| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 0| 0| 3| 0| 9| 4| 7| 2| 3| 3| 8| 0| 3| 3| 3| 9| 9| 3| 3| 9| 3| 3|            |
                                           | 6| 1| 3| 8| 8| 3| 0| 6| 1| 9| 6| 1| 2| 4| 9| 2| 2| 3| 6| 2| 2| 1| 7| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Perivascular, Atrophy                | 4                                                                        |      1  4.0|
      Rete Testes, Hyperplasia             |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |    4  4  4  1  4  4     4     4  4  4  4  2  4  4  4  4  4     4  4  4  4|     40  3.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +     +  +     +              +           +  +               |  16        |
      Femoral, Myelofibrosis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +     +  +     +  +           +  +        +  +        +      |  25        |
      Mandibular, Hyperplasia, Plasma Cell | 3                                                                        |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  2.0|
      Mediastinal, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             M     M  M     M              M           M  M               |   6        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Proliferative          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|  47        |
      Fibrosis                             | 2     2                                         3  1        2     2      |     10  1.8|
      Hematopoietic Cell Proliferation     |                                                          3               |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +     +  +     +              +           M  +               |  14        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +  +  +  +     +              +           +  +           +   |  15        |
      Hyperplasia, Cystic                  |                   2  4     1              2           2  1           4   |     12  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +           +  +  +  +     +  +  +        +  +  +     +  +           +   |  25        |
      Cyst Epithelial Inclusion            |             X                                                            |      1     |
      Inflammation, Chronic Active         |             2                                                            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +     +  +     +              +           +  +               |  16        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +     +  +     +              +           +  +               |  16        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +     +  +     +              +           +  +               |  16        |
      Compression                          |             X        X                                                   |      4     |
      Hemorrhage                           |             3                                                            |      1  3.0|
      Hydrocephalus                        |             3        3     4                                             |      5  2.8|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |             +     +  +     +              +           +  +               |  15        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |             +     +  +     +              +           +  +               |  15        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 6| 5| 6| 3| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 0| 0| 3| 0| 9| 4| 7| 2| 3| 3| 8| 0| 3| 3| 3| 9| 9| 3| 3| 9| 3| 3|            |
                                           | 6| 1| 3| 8| 8| 3| 0| 6| 1| 9| 6| 1| 2| 4| 9| 2| 2| 3| 6| 2| 2| 1| 7| 1| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |             +     +  +     +  +           +           +  +               |  17        |
      Bacterium                            |                                                                          |      1     |
      Granuloma                            |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Adenomatous                     |                                                       4                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |             +     +  +     +              +           +  +               |  16        |
      Inflammation, Chronic Active         |                                                          2               |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +     +  +     +              +           +  +               |  15        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                 +                          +   |   6        |
      Hemorrhage                           |                                                                      3   |      1  3.0|
      Lens, Cataract                       |                                                                          |      1  2.0|
      Retina, Atrophy                      |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +     +  +     M              +           +  +               |  12        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +        +   |  36        |
      Cyst                                 |    X                             X           X  X           X            |      8     |
      Inflammation, Chronic                |                               3                                          |      1  3.0|
      Nephropathy, Chronic                 |    4     3  3     3  4  4  1  3  4  3     2  4  4  3  2  2  4        4   |     36  3.2|
                                            __________________________________________________________________________|____________|
   Ureter                                  |             +     +        +              +           +  +               |  12        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +     +  +     +        +     +           +  +               |  18        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 3| 7| 7| 6| 7| 4|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 0| 9| 2| 3| 3| 3| 4| 2| 6| 3| 3| 5| 1| 2|             
                                           | 3| 1| 1| 3| 3| 3| 1| 2| 3| 5| 2| 8| 5| 6| 3| 2| 1| 8| 2| 7| 2| 1| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                    X        X                       X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X           X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X                                         X         |             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Degeneration, Cystic                 | 1  2        1     1        1  1              2  3                        |             
      Eosinophilic Focus                   |                   X                                                      |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic                |       1           1  1        1           1                       1      |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                | 3                                            2     4  3                  |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Acinus, Atrophy                      | 2     1  1     1  1  2  1                    2  2  2           2         |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       3                  |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                +         |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
      Pulmonary Artery, Mineralization     |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  3  2  2     2  2  2  3  2  2  2  3  2  3  2  3  3  3  2  3  2  3  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 3| 7| 7| 6| 7| 4|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 0| 9| 2| 3| 3| 3| 4| 2| 6| 3| 3| 5| 1| 2|             
                                           | 3| 1| 1| 3| 3| 3| 1| 2| 3| 5| 2| 8| 5| 6| 3| 2| 1| 8| 2| 7| 2| 1| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Fatty                  |          2                 2     1  2        1                           |             
      Hyperplasia                          |          2  1  2     1     2           1     2                 1         |             
      Hypertrophy                          |             2                 1                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        2  1  1  2  2                       3     2                  |             
      Necrosis, Coagulative                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | X                                         X                              |             
      Pars Distalis, Hyperplasia           |    2     2  2           2     1        1        2  1                 2   |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1              2           1  1           2                    1     2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +     +  +  +     +  +     +              +  +  +  +     +  +           +|             
                                            __________________________________________________________________________|             
   Ductus Deferens                         | +  +        +  +                    +           +        +     +         |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          3                                                               |             
      Inflammation, Chronic                |          2                                                               |             
      Pigmentation, Hemosiderin            |          2                                                               |             
                                            __________________________________________________________________________|             
   Penis                                   |                                  +           +                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       3                  |             
      Inflammation, Chronic Active         | 2  2     2     2  1  1  2     1     2  2  2  1  2  1  3  2  1  1  1  2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               1                                          |             
      Inflammation, Chronic Active         | 1     2  4     2  2  1           2  3  2  2  1  2     3  1     2     4  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +     +  +     +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1              1              1                 1     1     1            |             
      Interstitial Cell, Hyperplasia       | 1  1              1        2  1  2        1  2  2  2     2  1     2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 3| 7| 7| 6| 7| 4|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 0| 9| 2| 3| 3| 3| 4| 2| 6| 3| 3| 5| 1| 2|             
                                           | 3| 1| 1| 3| 3| 3| 1| 2| 3| 5| 2| 8| 5| 6| 3| 2| 1| 8| 2| 7| 2| 1| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Seminiferous Tubule, Atrophy         | 4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  3  4     4  4     4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                            +                                             |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Reticulum Cell |       1                                                                  |             
      Femoral, Myelofibrosis               |                                                                          |             
      Vertebral, Hyperplasia, Reticulum    |                                                                          |             
          Cell                             |       1                                                                  |             
      Vertebral, Myelofibrosis             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Pigmentation, Hemosiderin |                                                                          |             
      Mandibular, Cyst                     |                                  X                                       |             
      Mandibular, Hyperplasia, Plasma Cell |                                                                   2      |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                   2                                                      |             
      Renal, Pigmentation, Hemosiderin     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  M  M  M  M  +  M  M  +  M  M  M  M  M  M  M  +  M  M  M  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          2     3                                3  4                     |             
      Hematopoietic Cell Proliferation     | 3                 2              2        2                              |             
      Infarct                              |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  +  M  M  +  +  +  +  +  M  M  +  M  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  M  M  +|             
      Hyperplasia, Cystic                  | 2  3  2     1     4  1  2  2        4  2        1  1  4  2  1  1        1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      |                                                                          |             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
      Vertebra, Fibrous Osteodystrophy     |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   X              X  X                 X           X     X|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                  3  2                                    |             
      Thrombosis                           |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 3| 7| 7| 6| 7| 4|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 0| 9| 2| 3| 3| 3| 4| 2| 6| 3| 3| 5| 1| 2|             
                                           | 3| 1| 1| 3| 3| 3| 1| 2| 3| 5| 2| 8| 5| 6| 3| 2| 1| 8| 2| 7| 2| 1| 5| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      White Matter, Degeneration           |                1  1     1        1     1     2              2  1         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    3                     |             
      Alveolar Epithelium, Hyperplasia     |                2                                                         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Adenomatous                     |                                                                          |             
      Artery, Mediastinum, Necrosis,       |                                                                          |             
          Fibrinoid                        |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                              2  3                 1      |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        2                                 |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |    1                    3                    2  2              2  1  1   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          1                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +        +  +         |             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |                                                             3            |             
      Retina, Atrophy                      |                                                             4            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +        +     +        +     +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                                         X              X        X   |             
      Nephropathy, Chronic                 | 2  4  4  4  3  3  3  3  4  3  3  4  3  2  3  4  4  4  4  1  3  3  3  4  2|             
                                            __________________________________________________________________________|             
   Ureter                                  | +  +  +  +  +  +  +  +  +  +        +  +  +     +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Urethra                                 |          +  +  +                 +     +     +  +                 +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                3         |             
      Transitional Epithelium, Hyperplasia |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3|            |
                                           | 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    12 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    | X                       X                                                |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |       X                                                                 X|      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |          X                                X        X                     |      5     |
      Clear Cell Focus                     |                                           X                              |      1     |
      Clear Cell Focus, Multiple           |          X                                                               |      1     |
      Degeneration, Cystic                 | 1     2     2  1     4        1              2     2        4  2        2|     19  1.8|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |    X                                                                     |      1     |
      Inflammation, Chronic                |          2                                                               |      7  1.1|
      Mineralization                       |                                        2                                 |      1  2.0|
      Necrosis, Coagulative                |    3                                                                     |      5  3.0|
      Vacuolization Cytoplasmic            |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation, Hemosiderin            |                                                    2                     |      1  2.0|
      Acinus, Atrophy                      | 1        1                                         1        1            |     15  1.4|
      Acinus, Hyperplasia                  |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                2                                      3           3      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3|            |
                                           | 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    12 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |  48        |
      Aorta, Mineralization                |                                                                   3      |      1  3.0|
      Pulmonary Artery, Mineralization     |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              | 3  3  3  3  2  2  2  2  2  3  2  2  3     3  2  3  3  3  3  2  3  2  2  3|     48  2.5|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                   X                                                      |      1     |
      Degeneration, Fatty                  | 1                       1                                      3  2      |      9  1.7|
      Hyperplasia                          |             2  1     2     2        2                 2           2      |     15  1.7|
      Hypertrophy                          | 1                                            1                           |      4  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2           2  1           2              2                    2  2  2   |     16  1.9|
      Necrosis, Coagulative                |    3                                                                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|  45        |
      Hyperplasia                          |                3                                      4           4      |      3  3.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |          2           1     3                          2  2  2            |     15  1.8|
      Pars Intermedia, Angiectasis         |       2                                                                  |      1  2.0|
      Pars Intermedia, Cyst                |                                                             X            |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 2        2  1  2  2  2  2     2                          2     2         |     17  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |          +  +     +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |  32        |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         | +           +  +                    +  +     +     +     +  +     +     +|  19        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3|            |
                                           | 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    12 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         | 1  1     1  1  2  1  2  3  2  1        2  1  2  1  2  2  2  2  2  1  2   |     42  1.6|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 2     4  2        3  1  2     2  1  1  2                 2  1     3      |     30  2.1|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +        +  +     +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |             1                                1           1  1            |     10  1.0|
      Interstitial Cell, Hyperplasia       | 2     1  2  1  2  2        2  1        2        2           3        1  2|     27  1.7|
      Seminiferous Tubule, Atrophy         | 4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4     3  4|     46  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |             +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia, Reticulum Cell |                                                                          |      1  1.0|
      Femoral, Myelofibrosis               |                                                 4                        |      1  4.0|
      Vertebral, Hyperplasia, Reticulum    |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
      Vertebral, Myelofibrosis             |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bronchial, Pigmentation, Hemosiderin |                                  3                                       |      1  3.0|
      Mandibular, Cyst                     |                                                                          |      1     |
      Mandibular, Hyperplasia, Plasma Cell |                                                                          |      1  2.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                          1               |      2  1.5|
      Renal, Pigmentation, Hemosiderin     |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  M  M  +  M  M  M  M  M  M  +  M  +  M  M  M  M  +  M  M  M  M  M  M|   8        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                3        2     2     2        2                           |      9  2.6|
      Hematopoietic Cell Proliferation     |                                     2              2     2              2|      8  2.1|
      Infarct                              |                                                                      3   |      1  3.0|
      Pigmentation, Hemosiderin            |                               3        2        2                        |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  M  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  35        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|  39        |
      Hyperplasia, Cystic                  | 2     4  2  3     3  2  2     3     1  1  1  2     2  2  1  2  1  4     2|     36  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3|            |
                                           | 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    12 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Fibrous Osteodystrophy      |                                                       X           X      |      2     |
      Femur, Fibrous Osteodystrophy        |                                                       X           X      |      2     |
      Vertebra, Fibrous Osteodystrophy     |                                                       X           X      |      2     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                   X           X                                   X      |      9     |
      Hemorrhage                           |                               4                                          |      1  4.0|
      Hydrocephalus                        |                                                                          |      2  2.5|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      White Matter, Degeneration           | 1                 1     1     1     1     1  1  1  1  1  1  1        1   |     21  1.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Adenomatous                     |                3                                2              2         |      3  2.3|
      Artery, Mediastinum, Necrosis,       |                                                                          |            |
          Fibrinoid                        |          2                                                               |      1  2.0|
      Interstitium, Inflammation, Chronic  |          1                                                               |      4  1.8|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |       4                                                                  |      2  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         | 1                          2        2        2                          2|     12  1.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                        2                    1            |      3  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05024-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        N-METHYLOLACRYLAMIDE                                   Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:28:08  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3|            |
                                           | 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    12 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +           +                             +                  |   6        |
      Hemorrhage                           |                         4                                                |      1  4.0|
      Lens, Cataract                       |                                                       4                  |      2  3.5|
      Retina, Atrophy                      |                                                       4                  |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +     +                             +                              |   8        |
      Hemorrhage                           |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                      X                                   X               |      6     |
      Nephropathy, Chronic                 | 4  2  3  4  2  4  3  3  3  4  4  3  3  2  3  3  3  3  4  4  3  3  4  2  3|     50  3.2|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +        +  +  +        +  +     +  +  +     +  +           +     +  +  +|  36        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |       +        +     +           +           +  +  +  +  +     +        +|  19        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 490856-490856/490856


--multipart-boundary--