National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3752

TDMS Study 05025-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          ETHYLENE GLYCOL


NTP Experiment-Test: 05025-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 06:04:38




       Facility:  Southern Research Institute

       Chemical CAS #:  107-21-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10            9           10                                     
  Early Deaths                                                                                                                      
    Moribund                                           9            9           12           12                                     
    Dead                                               8           11            9            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           30           30           37                                     
  Animals Examined Microscopically                    50           50           51           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)         (18)         (21)         (49)                                   
      Inflammation                                                                            1 (2%)                                
   Intestine Large, Cecum                             (48)         (19)         (16)         (50)                                   
      Edema                                                                                   1 (2%)                                
      Lymphoid Tissue, Hyperplasia, Lymphoid                                                  1 (2%)                                
   Intestine Large, Colon                             (49)         (19)         (19)         (50)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
   Intestine Large, Rectum                            (49)         (19)         (17)         (50)                                   
      Edema                                                                                   1 (2%)                                
   Intestine Small, Ileum                             (47)         (19)         (16)         (50)                                   
      Amyloid Deposition                                                                      2 (4%)                                
      Dilatation                                                                 1 (6%)                                             
      Inflammation, Chronic                                                      1 (6%)                                             
      Lymphoid Tissue, Hyperplasia, Lymphoid                                                  2 (4%)                                
      Lymphoid Tissue, Inflammation, Granulomatous                                            1 (2%)                                
   Intestine Small, Jejunum                           (47)         (19)         (16)         (50)                                   
      Amyloid Deposition                                            1 (5%)                    1 (2%)                                
      Dilatation                                                                 1 (6%)                                             
   Liver                                              (50)         (50)         (51)         (50)                                   
      Angiectasis                                                   1 (2%)                                                          
      Basophilic Focus                                              1 (2%)                    1 (2%)                                
      Congestion                                                    1 (2%)                    1 (2%)                                
      Cyst                                                          1 (2%)                                                          
      Fatty Change                                                               2 (4%)       3 (6%)                                
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)       6 (12%)      7 (14%)      2 (4%)                                
      Hyperplasia, Lymphoid                           14 (28%)     14 (28%)     16 (31%)     12 (24%)                               
      Infarct                                          1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Mixed Cell                4 (8%)      10 (20%)     11 (22%)      4 (8%)                                
      Inflammation, Multifocal                        17 (34%)     10 (20%)     19 (37%)     24 (48%)                               
      Mineralization                                                             1 (2%)                                             
      Necrosis, Multifocal                             2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Pigmentation                                                                            1 (2%)                                
      Bile Duct, Hyperplasia                                        1 (2%)                                                          
      Hepatocyte, Erythrophagocytosis                                                         2 (4%)                                
      Hepatocyte, Centrilobular, Degeneration,                                                                                      
           Hyaline                                                               1 (2%)      26 (52%)                               
      Portal Vein, Media, Hyperplasia                                                         1 (2%)                                
   Mesentery                                          (17)         (7)          (15)         (7)                                    
      Cyst                                                                       1 (7%)                                             
      Edema                                                                                   1 (14%)                               
      Hemorrhage                                       1 (6%)                                                                       
      Inflammation, Suppurative                        6 (35%)      5 (71%)      9 (60%)      2 (29%)                               
      Fat, Necrosis                                    8 (47%)                                1 (14%)                               
   Pancreas                                           (49)         (21)         (22)         (50)                                   
      Atrophy, Diffuse                                              2 (10%)                                                         
      Atrophy, Focal                                                1 (5%)                    3 (6%)                                
      Ectopic Tissue                                                                          1 (2%)                                
      Hyperplasia, Lymphoid                                                                   2 (4%)                                
      Inflammation, Suppurative                                     1 (5%)       1 (5%)                                             
      Acinar Cell, Hypoplasia, Focal                                                          1 (2%)                                
      Duct, Dilatation                                 1 (2%)       1 (5%)       1 (5%)       3 (6%)                                
      Duct, Dilatation, Multiple                                                              1 (2%)                                
   Salivary Glands                                    (49)         (20)         (21)         (50)                                   
      Hyperplasia, Focal                               1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (20)         (20)         (50)                                   
      Inflammation, Focal                                                        1 (5%)       2 (4%)                                
      Mineralization                                   1 (2%)                                 1 (2%)                                
      Mucosa, Hyperplasia, Papillary                                                          1 (2%)                                
   Stomach, Glandular                                 (49)         (20)         (20)         (50)                                   
      Hyperplasia, Lymphoid                            2 (4%)                                 1 (2%)                                
      Inflammation, Focal                              1 (2%)                                 4 (8%)                                
      Mineralization                                   1 (2%)                                 3 (6%)                                
      Epithelium, Degeneration, Hyaline                                                       2 (4%)                                
      Epithelium, Metaplasia, Squamous                                                        1 (2%)                                
      Mucosa, Cyst                                                                            2 (4%)                                
   Tooth                                              (2)          (4)          (1)          (3)                                    
      Incisor, Dysplasia                               2 (100%)     4 (100%)     1 (100%)     3 (100%)                              
      Incisor, Inflammation, Suppurative                            1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (2)                       (1)                                    
      Aorta, Thrombosis                                             1 (50%)                                                         
      Mesenteric Artery, Inflammation, Chronic                      1 (50%)                   1 (100%)                              
   Heart                                              (50)         (20)         (21)         (50)                                   
      Infiltration Cellular, Mixed Cell                                          1 (5%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Artery, Media, Hyperplasia                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (21)         (21)         (50)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Amyloid Deposition                                                                      1 (2%)                                
      Angiectasis                                                                             1 (2%)                                
      Focal Cellular Change                                         1 (5%)                                                          
      Hematopoietic Cell Proliferation                                           1 (5%)                                             
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hyperplasia, Focal                                                                      1 (2%)                                
      Infiltration Cellular, Mixed Cell                             1 (5%)                                                          
      Inflammation, Suppurative                                                               1 (2%)                                
      Vacuolization Cytoplasmic, Focal                                                        2 (4%)                                
      Subcapsular, Hyperplasia, Focal                                                         1 (2%)                                
   Adrenal Gland, Medulla                             (48)         (21)         (21)         (50)                                   
      Ectopic Tissue                                                                          2 (4%)                                
      Hyperplasia, Focal                               1 (2%)       1 (5%)                    1 (2%)                                
   Parathyroid Gland                                  (49)         (18)         (14)         (42)                                   
      Cyst                                             1 (2%)                                                                       
   Pituitary Gland                                    (47)         (22)         (23)         (47)                                   
      Pars Distalis, Angiectasis                       1 (2%)                                                                       
      Pars Distalis, Bacterium                         1 (2%)                                                                       
      Pars Distalis, Cyst                              2 (4%)                                                                       
      Pars Distalis, Focal Cellular Change                          2 (9%)       2 (9%)                                             
      Pars Distalis, Hyperplasia, Focal               13 (28%)                   2 (9%)      14 (30%)                               
      Pars Distalis, Necrosis, Focal                                1 (5%)                                                          
      Pars Nervosa, Inflammation, Focal                                          1 (4%)                                             
   Thyroid Gland                                      (49)         (50)         (51)         (50)                                   
      Degeneration, Cystic                             4 (8%)       6 (12%)      4 (8%)       4 (8%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Inflammation, Focal                              3 (6%)                    3 (6%)       3 (6%)                                
      C-Cell, Hyperplasia                                                        1 (2%)       1 (2%)                                
      Follicular Cell, Hyperplasia                     8 (16%)     16 (32%)     22 (43%)     14 (28%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (2)          (1)                                                 
      Abdominal, Foreign Body                                       1 (50%)                                                         
      Abdominal, Infiltration Cellular, Lymphocyte                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (25)         (25)         (48)                                   
      Angiectasis                                      1 (2%)       2 (8%)                    3 (6%)                                
      Atrophy                                                                                 2 (4%)                                
      Fibrosis, Focal                                                                         1 (2%)                                
      Granuloma                                                                  1 (4%)                                             
      Hemorrhage                                                    1 (4%)                    2 (4%)                                
      Hyperplasia, Lymphoid                                                      1 (4%)                                             
      Inflammation, Chronic                                                      1 (4%)                                             
      Inflammation, Suppurative                        8 (16%)     10 (40%)      9 (36%)      3 (6%)                                
      Mineralization                                                                          2 (4%)                                
      Thrombosis                                                    1 (4%)                                                          
      Follicle, Cyst                                  11 (22%)      5 (20%)      8 (32%)      9 (19%)                               
      Follicle, Cyst, Multiple                                      1 (4%)                                                          
   Oviduct                                            (3)                       (4)          (1)                                    
      Hyperplasia, Cystic                                                                     1 (100%)                              
      Inflammation, Suppurative                        2 (67%)                   4 (100%)                                           
   Uterus                                             (50)         (45)         (45)         (50)                                   
      Angiectasis                                                   4 (9%)       1 (2%)       2 (4%)                                
      Hemorrhage                                                    1 (2%)       1 (2%)       2 (4%)                                
      Hydrometra                                       3 (6%)       4 (9%)       2 (4%)       4 (8%)                                
      Inflammation, Suppurative                        6 (12%)      7 (16%)      5 (11%)      3 (6%)                                
      Thrombosis                                                    1 (2%)                                                          
      Endometrium, Cyst                                1 (2%)                                 2 (4%)                                
      Endometrium, Hyperplasia, Cystic                44 (88%)     40 (89%)     40 (89%)     47 (94%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (20)         (21)         (50)                                   
      Hyperplasia, Neutrophil                          1 (2%)       1 (5%)       1 (5%)       2 (4%)                                
   Lymph Node                                         (50)         (24)         (22)         (50)                                   
      Iliac, Hyperplasia                                            1 (4%)       4 (18%)      1 (2%)                                
      Inguinal, Hyperplasia                                                                   1 (2%)                                
      Inguinal, Hyperplasia, Lymphoid                                            1 (5%)                                             
      Mediastinal, Angiectasis                                      1 (4%)                                                          
      Mediastinal, Hyperplasia                         3 (6%)       3 (13%)      3 (14%)      1 (2%)                                
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)       2 (8%)                    2 (4%)                                
      Mediastinal, Inflammation, Suppurative           5 (10%)      1 (4%)       1 (5%)                                             
      Mesenteric, Angiectasis                          4 (8%)       2 (8%)                    6 (12%)                               
      Mesenteric, Hyperplasia                          2 (4%)       1 (4%)       2 (9%)       2 (4%)                                
      Mesenteric, Hyperplasia, Lymphoid                5 (10%)                   2 (9%)       7 (14%)                               
      Mesenteric, Inflammation, Suppurative            2 (4%)                                                                       
      Pancreatic, Hyperplasia                                                    1 (5%)                                             
      Renal, Hyperplasia                               2 (4%)       1 (4%)       5 (23%)      1 (2%)                                
      Renal, Inflammation, Suppurative                 1 (2%)       1 (4%)                                                          
   Lymph Node, Mandibular                             (43)         (21)         (20)         (49)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia                                      1 (2%)                                 2 (4%)                                
      Hyperplasia, Lymphoid                            2 (5%)       1 (5%)       1 (5%)       6 (12%)                               
   Spleen                                             (49)         (29)         (28)         (50)                                   
      Depletion Cellular                               1 (2%)                                                                       
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                14 (29%)     12 (41%)     20 (71%)     13 (26%)                               
      Hyperplasia, Lymphoid                           11 (22%)      2 (7%)       6 (21%)     13 (26%)                               
   Thymus                                             (47)         (19)         (19)         (47)                                   
      Cyst                                                          1 (5%)                    1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Hyperplasia, Lymphoid                            7 (15%)      1 (5%)                    6 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (20)         (21)         (50)                                   
      Dilatation                                       4 (8%)                    1 (5%)       6 (12%)                               
      Hyperplasia                                      2 (4%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Duct, Metaplasia, Squamous                       1 (2%)                                                                       
   Skin                                               (49)         (43)         (40)         (50)                                   
      Inflammation, Chronic                           16 (33%)      5 (12%)      6 (15%)     11 (22%)                               
      Subcutaneous Tissue, Edema                                                              1 (2%)                                
      Subcutaneous Tissue, Hyperplasia, Lymphoid                                              1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                              2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (20)         (21)         (50)                                   
      Cranium, Hyperostosis                                                                   1 (2%)                                
      Distal, Joint, Femur, Arthrosis                  1 (2%)                                                                       
      Femur, Hyperostosis                                           1 (5%)                                                          
   Skeletal Muscle                                    (2)          (2)          (2)          (1)                                    
      Inflammation, Suppurative                                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (20)         (21)         (50)                                   
      Compression                                      1 (2%)       1 (5%)       1 (5%)       3 (6%)                                
      Gliosis                                                       1 (5%)                                                          
      Hemorrhage, Multifocal                           2 (4%)                                                                       
      Infiltration Cellular, Lymphocyte                             1 (5%)                                                          
      Necrosis, Focal                                               1 (5%)                                                          
      Artery, Inflammation, Chronic                                              1 (5%)                                             
      Artery, Meninges, Inflammation, Chronic                       1 (5%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Meninges, Hyperplasia, Lymphoid                                                         1 (2%)                                
      Meninges, Infiltration Cellular, Mixed Cell                                1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (51)         (50)                                   
      Bacterium                                        1 (2%)                                                                       
      Congestion                                                    2 (4%)       2 (4%)                                             
      Hemorrhage                                       2 (4%)                    4 (8%)                                             
      Hyperplasia, Lymphoid                           17 (34%)     16 (32%)     15 (29%)     21 (42%)                               
      Hyperplasia, Macrophage                                       2 (4%)       2 (4%)       1 (2%)                                
      Infiltration Cellular, Mixed Cell                3 (6%)       3 (6%)       3 (6%)       1 (2%)                                
      Inflammation, Granulomatous                                                2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
      Pigmentation                                                                            1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                                                       
      Artery, Inflammation                                                                    1 (2%)                                
      Artery, Media, Hyperplasia                       3 (6%)      10 (20%)     10 (20%)     23 (46%)                               
      Bronchiole, Bronchiectasis                                                 1 (2%)                                             
      Bronchiole, Epithelium, Hyperplasia                                        1 (2%)                                             
      Mediastinum, Inflammation, Suppurative           1 (2%)                    3 (6%)                                             
      Vein, Intima, Mineralization                     1 (2%)                                                                       
   Nose                                               (50)         (20)         (21)         (50)                                   
      Lumen, Exudate                                   2 (4%)                                 1 (2%)                                
      Lumen, Foreign Body                              1 (2%)                                 1 (2%)                                
      Mucosa, Angiectasis                              1 (2%)                                                                       
      Mucosa, Hemorrhage                               1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)                                                                       
   Trachea                                            (49)         (20)         (21)         (50)                                   
      Artery, Peritracheal Tissue, Inflammation,                                                                                    
           Chronic                                                  1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)          (1)                                    
      Atrophy                                                                    1 (100%)                                           
      Cataract                                                                                1 (100%)                              
      Fibrosis                                                                   1 (100%)                                           
      Retinal Detachment                                                                      1 (100%)                              
      Cornea, Inflammation                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Bacterium                                        1 (2%)       1 (2%)                                                          
      Cyst                                                                                    1 (2%)                                
      Infiltration Cellular, Mixed Cell                1 (2%)       2 (4%)                    1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                                     2 (4%)       2 (4%)                                             
      Metaplasia, Osseous                              1 (2%)       1 (2%)       3 (6%)                                             
      Necrosis, Multifocal                                          1 (2%)                                                          
      Nephropathy                                     25 (51%)     20 (40%)     33 (66%)     28 (56%)                               
      Capsule, Inflammation, Suppurative                            1 (2%)                                                          
      Pelvis, Dilatation                                                                      1 (2%)                                
      Renal Tubule, Degeneration, Hyaline                           3 (6%)                    2 (4%)                                
      Renal Tubule, Dilatation                                                   1 (2%)       1 (2%)                                
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
      Renal Tubule, Mineralization                     1 (2%)                                                                       
      Renal Tubule, Pigmentation                                                              2 (4%)                                
      Renal Tubule, Vacuolization Cytoplasmic                                    1 (2%)                                             
   Urinary Bladder                                    (49)         (19)         (21)         (50)                                   
      Hyperplasia, Lymphoid                            2 (4%)                                 5 (10%)                               
      Inflammation, Chronic                                                      1 (5%)       1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
      Transitional Epithelium, Hyperplasia                          1 (5%)                                                          
      Transitional Epithelium, Metaplasia, Squamous                                           1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  6            6            6            6                                     
  Early Deaths                                                                                                                      
    Dead                                              15            8           11           16                                     
    Moribund                                          10           14           11           15                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           32           32           23                                     
  Animals Examined Microscopically                    54           54           54           54                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (54)         (21)         (22)         (54)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
   Gallbladder                                        (51)         (19)         (16)         (48)                                   
      Inflammation                                     1 (2%)                    1 (6%)                                             
      Mucosa, Hyperplasia                                                        1 (6%)                                             
   Intestine Large, Cecum                             (52)         (18)         (18)         (49)                                   
      Parasite Metazoan                                                                       1 (2%)                                
   Intestine Large, Rectum                            (54)         (19)         (21)         (48)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Prolapse                                                      1 (5%)                                                          
   Intestine Small, Duodenum                          (53)         (20)         (18)         (46)                                   
      Mucosa, Inflammation, Suppurative                                                       1 (2%)                                
   Intestine Small, Ileum                             (53)         (17)         (17)         (45)                                   
      Perforation                                                   1 (6%)                                                          
      Lymphoid Tissue, Hyperplasia, Lymphoid                                                  1 (2%)                                
   Intestine Small, Jejunum                           (54)         (18)         (19)         (50)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
   Liver                                              (54)         (53)         (53)         (54)                                   
      Angiectasis                                      1 (2%)                                                                       
      Autolysis                                                                               1 (2%)                                
      Bacterium                                                                               2 (4%)                                
      Basophilic Focus                                 1 (2%)       2 (4%)                    2 (4%)                                
      Congestion                                                                 1 (2%)       1 (2%)                                
      Cyst                                                                       1 (2%)                                             
      Eosinophilic Focus                               2 (4%)                                 1 (2%)                                
      Fatty Change                                                  2 (4%)                                                          
      Fibrosis                                                                                2 (4%)                                
      Focal Cellular Change                            1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                              3 (6%)       1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            2 (4%)       3 (6%)       3 (6%)       2 (4%)                                
      Hyperplasia, Multifocal                          1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infarct                                                                                 1 (2%)                                
      Infiltration Cellular, Mixed Cell                4 (7%)       5 (9%)       2 (4%)       8 (15%)                               
      Inflammation, Multifocal                         6 (11%)     11 (21%)     16 (30%)     13 (24%)                               
      Necrosis, Multifocal                            10 (19%)      6 (11%)      4 (8%)       8 (15%)                               
      Pigmentation                                                  1 (2%)       1 (2%)       3 (6%)                                
      Artery, Media, Hypertrophy                                                              1 (2%)                                
      Bile Duct, Cyst                                  1 (2%)                                                                       
      Bile Duct, Hyperplasia                           1 (2%)                                                                       
      Centrilobular, Necrosis                                       1 (2%)       2 (4%)       1 (2%)                                
      Centrilobular, Vacuolization Nuclear                                                    1 (2%)                                
      Hepatocyte, Cytomegaly                                        1 (2%)                                                          
      Hepatocyte, Centrilobular, Degeneration,                                                                                      
           Hyaline                                                              24 (45%)     36 (67%)                               
   Mesentery                                          (5)          (3)          (1)          (7)                                    
      Inflammation, Chronic                                         2 (67%)      1 (100%)     1 (14%)                               
      Inflammation, Granulomatous                                                             1 (14%)                               
      Inflammation, Suppurative                        1 (20%)                                3 (43%)                               
      Fat, Necrosis                                                                           1 (14%)                               
   Pancreas                                           (54)         (23)         (21)         (54)                                   
      Atrophy, Focal                                                1 (4%)                                                          
      Fibrosis, Focal                                  1 (2%)                                                                       
      Focal Cellular Change                            1 (2%)                                                                       
      Inflammation, Chronic, Focal                                                            2 (4%)                                
      Necrosis, Focal                                  1 (2%)                                                                       
      Duct, Degeneration, Hyaline                      1 (2%)                                                                       
      Duct, Dilatation                                 1 (2%)                    1 (5%)                                             
      Duct, Hyperplasia, Papillary                     1 (2%)                                                                       
      Duct, Metaplasia                                 1 (2%)                                                                       
      Vein, Infiltration Cellular, Mixed Cell          1 (2%)                                                                       
   Salivary Glands                                    (53)         (21)         (20)         (54)                                   
      Atrophy, Focal                                   1 (2%)                                                                       
      Fibrosis, Focal                                  1 (2%)                                                                       
   Stomach, Forestomach                               (54)         (20)         (21)         (54)                                   
      Mineralization                                   1 (2%)                                                                       
      Mucosa, Hyperplasia, Papillary                   2 (4%)                                                                       
      Mucosa, Ulcer                                                                           1 (2%)                                
   Stomach, Glandular                                 (54)         (20)         (21)         (54)                                   
      Erosion                                                       1 (5%)                                                          
      Inflammation, Focal                              1 (2%)                    1 (5%)       1 (2%)                                
      Mineralization                                   2 (4%)                    2 (10%)                                            
      Epithelium, Metaplasia, Squamous                 1 (2%)                                                                       
      Epithelium, Vacuolization Cytoplasmic,                                                                                        
          Multifocal                                                                          1 (2%)                                
      Mucosa, Cyst                                     2 (4%)                                                                       
      Mucosa, Erosion                                                                         1 (2%)                                
   Tooth                                              (21)         (4)          (1)          (18)                                   
      Incisor, Dysplasia                              18 (86%)      4 (100%)     1 (100%)    15 (83%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Incisor, Inflammation, Chronic                   1 (5%)                                                                       
      Incisor, Inflammation, Suppurative               2 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (54)         (21)         (22)         (54)                                   
      Inflammation, Chronic                            3 (6%)                                 1 (2%)                                
      Inflammation, Focal                                                                     1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                 3 (6%)                                
      Atrium, Thrombosis, Multiple                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (54)         (20)         (21)         (54)                                   
      Cyst                                             1 (2%)                                                                       
      Focal Cellular Change                                                                   1 (2%)                                
      Hyperplasia, Focal                                            1 (5%)                    1 (2%)                                
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Extra Adrenal Tissue, Fibrosis                   1 (2%)                                                                       
      Extra Adrenal Tissue, Inflammation,                                                                                           
          Suppurative                                                                         1 (2%)                                
      Subcapsular, Hyperplasia, Focal                  2 (4%)                    2 (10%)      4 (7%)                                
      Unilateral, Atrophy                                                        1 (5%)                                             
   Adrenal Gland, Medulla                             (54)         (21)         (21)         (53)                                   
      Hyperplasia, Focal                               1 (2%)                    1 (5%)       1 (2%)                                
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
   Parathyroid Gland                                  (53)         (18)         (22)         (50)                                   
      Cyst                                                                       1 (5%)                                             
   Pituitary Gland                                    (52)         (21)         (17)         (49)                                   
      Pars Distalis, Angiectasis                                                 1 (6%)                                             
      Pars Distalis, Cyst                                                                     1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                5 (10%)                   1 (6%)       2 (4%)                                
   Thyroid Gland                                      (53)         (53)         (54)         (53)                                   
      Cyst                                             1 (2%)                    2 (4%)                                             
      Degeneration, Cystic                            12 (23%)     13 (25%)     13 (24%)      9 (17%)                               
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Focal                              1 (2%)                                                                       
      Follicle, Cyst                                                1 (2%)       4 (7%)                                             
      Follicular Cell, Hyperplasia                     5 (9%)       8 (15%)      4 (7%)       9 (17%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                                            (1)          (1)                                    
      Inflammation, Suppurative                                                               1 (100%)                              
      Adventitia, Hemorrhage                                                     1 (100%)                                           
   Ductus Deferens                                                                           (1)                                    
      Inflammation, Chronic                                                                   1 (100%)                              
   Epididymis                                         (54)         (21)         (22)         (54)                                   
      Granuloma Sperm                                                            1 (5%)       1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic                                                                   2 (4%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Spermatocele                                     1 (2%)                                                                       
   Penis                                              (5)          (1)          (4)          (6)                                    
      Fibrosis                                                      1 (100%)                                                        
      Hyperplasia                                                                             1 (17%)                               
      Inflammation, Chronic                            1 (20%)      1 (100%)     3 (75%)      1 (17%)                               
      Inflammation, Suppurative                        1 (20%)                                                                      
      Necrosis                                         2 (40%)                   1 (25%)                                            
   Preputial Gland                                    (12)         (6)          (7)          (12)                                   
      Degeneration, Cystic                             8 (67%)      3 (50%)      3 (43%)      6 (50%)                               
      Inflammation, Suppurative                        8 (67%)      5 (83%)      2 (29%)      7 (58%)                               
   Prostate                                           (53)         (20)         (22)         (54)                                   
      Dilatation                                                                              1 (2%)                                
      Edema                                                                                   1 (2%)                                
      Inflammation, Chronic                            6 (11%)      1 (5%)       5 (23%)     10 (19%)                               
   Seminal Vesicle                                    (52)         (23)         (23)         (54)                                   
      Dilatation                                       4 (8%)       3 (13%)      2 (9%)       4 (7%)                                
      Inflammation, Chronic                            9 (17%)      3 (13%)      1 (4%)       8 (15%)                               
      Epithelium, Hyperplasia                                       1 (4%)                                                          
   Testes                                             (54)         (22)         (22)         (54)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Mineralization                                   1 (2%)       1 (5%)       1 (5%)       3 (6%)                                
      Necrosis, Multifocal                                                                    1 (2%)                                
      Germinal Epithelium, Degeneration                3 (6%)       1 (5%)       1 (5%)       5 (9%)                                
      Interstitial Cell, Hyperplasia                                                          1 (2%)                                
      Tunic, Proliferation Connective Tissue                                     1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)          (3)                       (1)                                    
      Neutrophilia                                     1 (100%)                                                                     
   Bone Marrow                                        (54)         (21)         (22)         (54)                                   
      Atypia Cellular, Focal                                                                  1 (2%)                                
      Hyperplasia, Neutrophil                          1 (2%)                    1 (5%)                                             
   Lymph Node                                         (54)         (33)         (27)         (54)                                   
      Iliac, Hyperplasia                               1 (2%)                    1 (4%)       3 (6%)                                
      Inguinal, Hyperplasia                            2 (4%)       1 (3%)       4 (15%)      1 (2%)                                
      Inguinal, Hyperplasia, Lymphoid                                                         2 (4%)                                
      Inguinal, Inflammation, Chronic                  1 (2%)                                 1 (2%)                                
      Mesenteric, Angiectasis                         19 (35%)     17 (52%)     11 (41%)     22 (41%)                               
      Mesenteric, Depletion Lymphoid                   1 (2%)                                                                       
      Mesenteric, Hematopoietic Cell Proliferation                                            1 (2%)                                
      Mesenteric, Hyperplasia                                                                 3 (6%)                                
      Mesenteric, Hyperplasia, Lymphoid                1 (2%)       2 (6%)                    2 (4%)                                
      Mesenteric, Hyperplasia, Reticulum Cell                                                 1 (2%)                                
      Mesenteric, Inflammation, Chronic,                                                                                            
          Granulomatous                                                                       1 (2%)                                
      Mesenteric, Inflammation, Suppurative                                                   1 (2%)                                
      Mesenteric, Thrombosis                                                                  1 (2%)                                
   Lymph Node, Mandibular                             (45)         (19)         (17)         (51)                                   
      Angiectasis                                      2 (4%)                                                                       
      Depletion Lymphoid                               1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                 4 (8%)                                
   Spleen                                             (54)         (53)         (53)         (53)                                   
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                                                              1 (2%)                                
      Depletion Cellular                               1 (2%)       3 (6%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                17 (31%)     25 (47%)     25 (47%)     28 (53%)                               
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)       2 (4%)                                
   Thymus                                             (53)         (19)         (19)         (51)                                   
      Atypia Cellular                                                                         1 (2%)                                
      Cyst                                             1 (2%)       1 (5%)                    1 (2%)                                
      Degeneration, Cystic                                                                    1 (2%)                                
      Depletion Lymphoid                               1 (2%)       2 (11%)      3 (16%)      7 (14%)                               
      Hyperplasia, Reticulum Cell                                                             1 (2%)                                
      Epithelial Cell, Hyperplasia, Cystic             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (54)         (45)         (43)         (54)                                   
      Erosion                                                                                 1 (2%)                                
      Exudate                                                       1 (2%)                    1 (2%)                                
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia, Melanocyte                                                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Chronic                           25 (46%)     24 (53%)     27 (63%)     18 (33%)                               
      Metaplasia, Osseous                                           1 (2%)       1 (2%)                                             
      Ulcer                                            4 (7%)       5 (11%)      5 (12%)      9 (17%)                               
      Hair Follicle, Atrophy                           1 (2%)       1 (2%)       2 (5%)                                             
      Prepuce, Angiectasis                             1 (2%)                                                                       
      Prepuce, Fibrosis                                1 (2%)                                                                       
      Prepuce, Foreign Body                            1 (2%)       1 (2%)                                                          
      Prepuce, Inflammation, Chronic                   5 (9%)       1 (2%)       2 (5%)       2 (4%)                                
      Prepuce, Ulcer                                   5 (9%)       1 (2%)       3 (7%)       3 (6%)                                
      Subcutaneous Tissue, Edema                       1 (2%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Exudate                     1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosis                                 1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Foreign Body                1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)                                                                       
      Subcutaneous Tissue, Lymphatic, Angiectasis                                             1 (2%)                                
      Tail, Subcutaneous Tissue, Inflammation,                                                                                      
           Granulomatous                                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (54)         (21)         (22)         (54)                                   
      Distal, Joint, Femur, Arthrosis                  1 (2%)       1 (5%)                                                          
      Femur, Hyperostosis                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (54)         (21)         (22)         (54)                                   
      Congestion                                                                              1 (2%)                                
      Gliosis                                          1 (2%)                                                                       
      Infiltration Cellular, Mixed Cell                                          1 (5%)                                             
      Inflammation, Focal                                                        1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (54)         (25)         (32)         (54)                                   
      Bacterium                                                                               2 (4%)                                
      Congestion                                       5 (9%)       2 (8%)       3 (9%)       3 (6%)                                
      Edema                                                         1 (4%)                                                          
      Foreign Body                                                                            1 (2%)                                
      Hemorrhage                                                                              2 (4%)                                
      Hyperplasia, Lymphoid                            4 (7%)                    2 (6%)       4 (7%)                                
      Hyperplasia, Macrophage                          1 (2%)                    2 (6%)       1 (2%)                                
      Infiltration Cellular, Mixed Cell                8 (15%)      2 (8%)       7 (22%)      8 (15%)                               
      Inflammation, Granulomatous                                                             1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Pigmentation                                                                            1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 2 (4%)                    2 (6%)                                             
      Artery, Embolus                                  1 (2%)                                                                       
      Interstitium, Inflammation                                    1 (4%)                    1 (2%)                                
   Nose                                               (54)         (21)         (21)         (54)                                   
      Lumen, Exudate                                   2 (4%)       2 (10%)                                                         
      Lumen, Foreign Body                                           1 (5%)                                                          
      Nasolacrimal Duct, Foreign Body                  1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Suppurative     2 (4%)       1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (54)         (53)         (53)         (54)                                   
      Angiectasis                                                   1 (2%)                                                          
      Atrophy, Focal                                                             1 (2%)       1 (2%)                                
      Bacterium                                        2 (4%)                    1 (2%)       4 (7%)                                
      Congestion                                       3 (6%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Inflammation, Suppurative                        4 (7%)       1 (2%)       1 (2%)       4 (7%)                                
      Metaplasia, Osseous                              1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Necrosis                                                                   1 (2%)                                             
      Necrosis, Focal                                                                         2 (4%)                                
      Nephropathy                                     39 (72%)     44 (83%)     41 (77%)     38 (70%)                               
      Papilla, Necrosis                                             1 (2%)       1 (2%)                                             
      Pelvis, Crystals                                                                        1 (2%)                                
      Pelvis, Dilatation                                                                      2 (4%)                                
      Pelvis, Inflammation, Chronic                                                           2 (4%)                                
      Pelvis, Mineralization                                                                  2 (4%)                                
      Pelvis, Transitional Epithelium, Hyperplasia                                            1 (2%)                                
      Renal Tubule, Crystals                                                                  8 (15%)                               
      Renal Tubule, Degeneration, Hyaline                           1 (2%)                    1 (2%)                                
      Renal Tubule, Dilatation                         6 (11%)      2 (4%)       7 (13%)     13 (24%)                               
      Renal Tubule, Hyperplasia                                                  1 (2%)                                             
      Renal Tubule, Mineralization                                  1 (2%)       1 (2%)                                             
      Renal Tubule, Necrosis                           1 (2%)                                                                       
      Renal Tubule, Vacuolization Cytoplasmic         51 (94%)     50 (94%)     48 (91%)     52 (96%)                               
      Renal Tubule, Epithelium, Necrosis                            2 (4%)                    1 (2%)                                
   Urethra                                            (1)          (4)          (2)          (18)                                   
      Fibrosis                                                      1 (25%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05025-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Hemorrhage                                                                              1 (6%)                                
      Inflammation, Suppurative                        1 (100%)     2 (50%)      2 (100%)     7 (39%)                               
      Perforation                                      1 (100%)                                                                     
      Bulbourethral Gland, Dilatation                               2 (50%)                   1 (6%)                                
      Bulbourethral Gland, Fibrosis                                 1 (25%)                                                         
      Lumen, Crystals                                                                        12 (67%)                               
   Urinary Bladder                                    (53)         (53)         (53)         (54)                                   
      Calculus Gross Observation                                                              2 (4%)                                
      Calculus Micro Observation Only                                                         2 (4%)                                
      Congestion                                       1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)       4 (8%)       6 (11%)      8 (15%)                               
      Ulcer                                                                                   1 (2%)                                
      Artery, Serosa, Mineralization                                                          1 (2%)                                
      Transitional Epithelium, Hyperplasia             1 (2%)       1 (2%)                    1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.