National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3756

TDMS Study 05025-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          ETHYLENE GLYCOL


NTP Experiment-Test: 05025-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 06:04:43




       Facility:  Southern Research Institute

       Chemical CAS #:  107-21-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05025-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10            9           10                                     
  Early Deaths                                                                                                                      
    Moribund                                           9            9           12           12                                     
    Dead                                               8           11            9            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           30           30           37                                     
  Animals Examined Microscopically                    50           50           51           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (20)         (21)         (50)                                   
   Gallbladder                                        (48)         (18)         (21)         (49)                                   
   Intestine Large, Cecum                             (48)         (19)         (16)         (50)                                   
   Intestine Large, Colon                             (49)         (19)         (19)         (50)                                   
      Sarcoma                                                       1 (5%)                                                          
   Intestine Large, Rectum                            (49)         (19)         (17)         (50)                                   
   Intestine Small, Duodenum                          (47)         (18)         (17)         (50)                                   
   Intestine Small, Ileum                             (47)         (19)         (16)         (50)                                   
   Intestine Small, Jejunum                           (47)         (19)         (16)         (50)                                   
   Liver                                              (50)         (50)         (51)         (50)                                   
      Adenocarcinoma, Multiple, Metastatic, Ovary                   1 (2%)                                                          
      Hepatocellular Carcinoma                         3 (6%)       4 (8%)       6 (12%)      3 (6%)                                
      Hepatocellular Carcinoma, Multiple, Two                       1 (2%)                                                          
      Hepatocellular Adenoma                           8 (16%)      5 (10%)      8 (16%)      7 (14%)                               
   Mesentery                                          (17)         (7)          (15)         (7)                                    
      Adenocarcinoma, Multiple, Metastatic, Ovary                   1 (14%)                                                         
      Sarcoma                                                       1 (14%)                   1 (14%)                               
   Pancreas                                           (49)         (21)         (22)         (50)                                   
      Adenocarcinoma, Metastatic, Ovary                             1 (5%)                                                          
      Sarcoma                                                       1 (5%)                                                          
   Salivary Glands                                    (49)         (20)         (21)         (50)                                   
   Stomach, Forestomach                               (50)         (20)         (20)         (50)                                   
   Stomach, Glandular                                 (49)         (20)         (20)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (20)         (21)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05025-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (21)         (21)         (50)                                   
   Adrenal Gland, Medulla                             (48)         (21)         (21)         (50)                                   
      Pheochromocytoma Malignant                                    1 (5%)                                                          
      Pheochromocytoma Benign                                       1 (5%)       1 (5%)                                             
   Islets, Pancreatic                                 (49)         (19)         (21)         (50)                                   
      Adenoma                                                       1 (5%)                                                          
   Pituitary Gland                                    (47)         (22)         (23)         (47)                                   
      Pars Distalis, Adenoma                          17 (36%)      5 (23%)      7 (30%)     16 (34%)                               
      Pars Distalis, Carcinoma                                                   1 (4%)                                             
      Pars Intermedia, Adenoma                                      1 (5%)                    1 (2%)                                
   Thyroid Gland                                      (49)         (50)         (51)         (50)                                   
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (2)          (1)                                                 
      Sarcoma                                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (25)         (25)         (48)                                   
      Adenocarcinoma                                                1 (4%)                                                          
      Cystadenoma, Papillary                           2 (4%)       1 (4%)       1 (4%)       4 (8%)                                
      Teratoma NOS                                                                            1 (2%)                                
   Oviduct                                            (3)                       (4)          (1)                                    
   Uterus                                             (50)         (45)         (45)         (50)                                   
      Adenocarcinoma                                                                          1 (2%)                                
      Leiomyosarcoma                                                                          1 (2%)                                
      Endometrium, Polyp Stromal                       3 (6%)       3 (7%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (20)         (21)         (50)                                   
   Lymph Node                                         (50)         (24)         (22)         (50)                                   
      Mediastinal, Adenocarcinoma, Metastatic,                                                                                      
           Ovary                                                    1 (4%)                                                          
   Lymph Node, Mandibular                             (43)         (21)         (20)         (49)                                   
   Spleen                                             (49)         (29)         (28)         (50)                                   
      Hemangiosarcoma                                                            1 (4%)                                             
   Thymus                                             (47)         (19)         (19)         (47)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05025-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (20)         (21)         (50)                                   
      Adenoacanthoma                                                                          1 (2%)                                
      Adenocarcinoma                                   1 (2%)                    1 (5%)                                             
   Skin                                               (49)         (43)         (40)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                                          2 (5%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (3%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (20)         (21)         (50)                                   
      Osteosarcoma                                                  1 (5%)       1 (5%)                                             
   Skeletal Muscle                                    (2)          (2)          (2)          (1)                                    
      Osteosarcoma, Metastatic, Bone                                1 (50%)                                                         
      Abdominal, Sarcoma                                                                      1 (100%)                              
      Neck, Sarcoma                                                 1 (50%)                                                         
      Thoracic, Sarcoma                                             1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (20)         (21)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (51)         (50)                                   
      Adenocarcinoma, Multiple, Metastatic,                                                                                         
          Greater Than Five, Ovary                                  1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                                  4 (8%)       4 (8%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       2 (4%)       2 (4%)                                             
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Uncertain Primary Site                                           1 (2%)                                
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Greater Than Five, Liver         1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Nose                                               (50)         (20)         (21)         (50)                                   
   Trachea                                            (49)         (20)         (21)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05025-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (2)          (2)          (2)                                    
      Adenoma                                          2 (67%)      1 (50%)      1 (50%)                                            
      Carcinoma                                                     1 (50%)      1 (50%)      2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Urinary Bladder                                    (49)         (19)         (21)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(51)        *(50)                                   
      Lymphoma Malignant Histiocytic                                2 (4%)       2 (4%)       1 (2%)                                
      Lymphoma Malignant Lymphocytic                   3 (6%)       3 (6%)       4 (8%)                                             
      Lymphoma Malignant Mixed                        13 (26%)      8 (16%)      3 (6%)       6 (12%)                               
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05025-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     1.25%        2.5%         5.0%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          33          31          36                                       
     Total Primary Neoplasms                           56          53          49          51                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          19          19          26                                       
     Total Benign Neoplasms                            33          23          24          33                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          21          22          16                                       
     Total Malignant Neoplasms                         23          30          25          17                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2           2           2                                       
     Total Metastatic Neoplasm                          2           6           3           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1                                       
     Total Uncertain Neoplasms                                                              1                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05025-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  6            6            6            6                                     
  Early Deaths                                                                                                                      
    Dead                                              15            8           11           16                                     
    Moribund                                          10           14           11           15                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           32           32           23                                     
  Animals Examined Microscopically                    54           54           54           54                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (51)         (19)         (16)         (48)                                   
      Sarcoma                                          1 (2%)                                                                       
   Intestine Small, Duodenum                          (53)         (20)         (18)         (46)                                   
      Polyp Adenomatous                                             1 (5%)                                                          
   Intestine Small, Ileum                             (53)         (17)         (17)         (45)                                   
   Intestine Small, Jejunum                           (54)         (18)         (19)         (50)                                   
      Polyp Adenomatous                                2 (4%)                                 1 (2%)                                
   Liver                                              (54)         (53)         (53)         (54)                                   
      Cholangiocarcinoma                               1 (2%)                                                                       
      Hemangiosarcoma, Multiple, Two                   1 (2%)                                                                       
      Hepatocellular Carcinoma                        10 (19%)     15 (28%)     10 (19%)      9 (17%)                               
      Hepatocellular Carcinoma, Multiple, Two                       1 (2%)       2 (4%)                                             
      Hepatocellular Carcinoma, Multiple, Four                      1 (2%)                                                          
      Hepatocellular Adenoma                           9 (17%)      6 (11%)      5 (9%)       8 (15%)                               
      Hepatocellular Adenoma, Multiple, Two                                                   2 (4%)                                
      Serosa, Sarcoma                                  1 (2%)                                                                       
   Mesentery                                          (5)          (3)          (1)          (7)                                    
      Cholangiocarcinoma, Metastatic, Liver            1 (20%)                                                                      
      Hemangiosarcoma                                  1 (20%)                                                                      
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (33%)                                                         
      Sarcoma                                          1 (20%)                                                                      
   Pancreas                                           (54)         (23)         (21)         (54)                                   
   Salivary Glands                                    (53)         (21)         (20)         (54)                                   
   Stomach, Forestomach                               (54)         (20)         (21)         (54)                                   
      Mast Cell Tumor Benign                           1 (2%)                                                                       
   Stomach, Glandular                                 (54)         (20)         (21)         (54)                                   
   Tooth                                              (21)         (4)          (1)          (18)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05025-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (54)         (21)         (22)         (54)                                   
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (54)         (20)         (21)         (54)                                   
      Adenoma                                          2 (4%)                                                                       
      Capsule, Cholangiocarcinoma, Metastatic,                                                                                      
           Liver                                       1 (2%)                                                                       
      Capsule, Sarcoma                                 1 (2%)                                                                       
      Subcapsular, Adenoma                             1 (2%)                                 3 (6%)                                
      Subcapsular, Adenoma, Multiple                   1 (2%)                                                                       
   Adrenal Gland, Medulla                             (54)         (21)         (21)         (53)                                   
      Pheochromocytoma Benign                          1 (2%)       1 (5%)                                                          
   Pituitary Gland                                    (52)         (21)         (17)         (49)                                   
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (53)         (53)         (54)         (53)                                   
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)                                                                           
      Sarcoma                                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (54)         (21)         (22)         (54)                                   
      Hemangioma                                                                              1 (2%)                                
   Prostate                                           (53)         (20)         (22)         (54)                                   
      Sarcoma                                          1 (2%)                                                                       
   Seminal Vesicle                                    (52)         (23)         (23)         (54)                                   
      Sarcoma                                          1 (2%)                                                                       
   Testes                                             (54)         (22)         (22)         (54)                                   
      Interstitial Cell, Adenoma                                    1 (5%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05025-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (54)         (21)         (22)         (54)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (54)         (33)         (27)         (54)                                   
   Lymph Node, Mandibular                             (45)         (19)         (17)         (51)                                   
   Spleen                                             (54)         (53)         (53)         (53)                                   
      Hemangiosarcoma                                  2 (4%)                    1 (2%)                                             
   Thymus                                             (53)         (19)         (19)         (51)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (54)         (45)         (43)         (54)                                   
      Basosquamous Tumor Benign                                     1 (2%)                                                          
      Mast Cell Tumor Benign                           1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma                3 (6%)       8 (18%)      5 (12%)      1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma, Multifocal                              1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma,                                                                                            
          Metastatic, Skin                                                                    1 (2%)                                
      Subcutaneous Tissue, Histiocytic Sarcoma         2 (4%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Sarcoma, Multiple                                                  1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant                                               1 (2%)                                
      Subcutaneous Tissue, Schwannoma NOS                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
      Diaphragm, Cholangiocarcinoma, Metastatic,                                                                                    
           Liver                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (54)         (25)         (32)         (54)                                   
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     6 (11%)      2 (8%)       7 (22%)      3 (6%)                                
      Alveolar/Bronchiolar Adenoma, Multiple, Two                                1 (3%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple,                                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05025-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Greater Than Five                            1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (4%)       2 (6%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple, Two                 1 (4%)                                                          
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Fibrosarcoma, Multiple, Metastatic, Skin                                                1 (2%)                                
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Four, Liver                                                1 (3%)                                             
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Five, Liver                                   1 (4%)                                                          
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Greater Than Five, Liver                                   1 (3%)                                             
      Mediastinum, Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                
      Mediastinum, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                      1 (3%)                                             
      Pleura, Fibrosarcoma, Multiple, Metastatic,                                                                                   
           Skin                                                                               1 (2%)                                
   Nose                                               (54)         (21)         (21)         (54)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                              (2)          (3)                                    
      Adenoma                                                                    2 (100%)     2 (67%)                               
      Carcinoma                                                                               1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (54)         (53)         (53)         (54)                                   
      Carcinoma, Metastatic, Uncertain Primary Site                              1 (2%)                                             
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Capsule, Sarcoma                                 1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)                                 1 (2%)                                
   Urinary Bladder                                    (53)         (53)         (53)         (54)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(54)        *(54)        *(54)        *(54)                                   
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Lymphoma Malignant Histiocytic                                                          1 (2%)                                
      Lymphoma Malignant Lymphocytic                                                          1 (2%)                                
      Lymphoma Malignant Mixed                         6 (11%)      3 (6%)       5 (9%)       6 (11%)                               
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05025-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 06:04:43  
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         B6C3F1 MICE MALE                          UNTREATD     0.625%       1.25%        2.5%                                      
                                                    CONTROL                                                                         
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            34          36          31          33                                       
     Total Primary Neoplasms                           67          46          44          47                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 17          11          13          19                                       
     Total Benign Neoplasms                            29          14          17          24                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          28          23          20                                       
     Total Malignant Neoplasms                         38          31          27          23                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2           2           1                                       
     Total Metastatic Neoplasm                          7           3           4           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.