National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3760

TDMS Study 05025-01 Pathology Tables

NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97
Route: DOSED FEED                                                                                                 Time: 09:01:29




       Facility:  Southern Research Institute

       Chemical CAS #:  107-21-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 5| 6| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 9| 3| 6| 3| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 7| 9| 3| 3| 0| 3|             
                                           | 1| 1| 1| 1| 5| 7| 1| 5| 6| 6| 8| 6| 6| 6| 6| 2| 6| 6| 6| 4| 6| 6| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Hyperplasia, Lymphoid                | 1     1  1                          1                 1     1     1      |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                2        2|             
      Inflammation, Multifocal             |       1           1     1  1  1  1  1     1                 1     1      |             
      Necrosis, Multifocal                 |                                                    3        1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                          +           +     +     +     +        +|             
      Hemorrhage                           |                                                    2                     |             
      Inflammation, Suppurative            |                                              4           3     4        4|             
      Fat, Necrosis                        |       3                          3                             3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Duct, Dilatation                     |                                           3                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1                                                                        |             
      Inflammation, Focal                  |                                                                   1      |             
      Mineralization                       |                                     1                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
      Incisor, Dysplasia                   |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Media, Hyperplasia           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 5| 6| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 9| 3| 6| 3| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 7| 9| 3| 3| 0| 3|             
                                           | 1| 1| 1| 1| 5| 7| 1| 5| 6| 6| 8| 6| 6| 6| 6| 2| 6| 6| 6| 4| 6| 6| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hemorrhage, Focal                    |                                                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                        2                                 |             
      Pars Distalis, Bacterium             |                                                                          |             
      Pars Distalis, Cyst                  |                   2           1                                          |             
      Pars Distalis, Hyperplasia, Focal    |    2                    2     1     1  2                             1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                2         |             
      Inflammation, Focal                  |                                                             1           1|             
      Follicular Cell, Hyperplasia         |                   3                             1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                                               |             
      Inflammation, Suppurative            |                   4                 3        4           4     4        4|             
      Follicle, Cyst                       |                      3     2              3           1        3  3      |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                     +                                   +|             
      Inflammation, Suppurative            |                                     3                                   4|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                            2              3                              |             
      Inflammation, Suppurative            |                   2                 2              2                    4|             
      Endometrium, Cyst                    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  3  2  1  3  2  3     3  2  2  2  3     3     2  1  2     1  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia             |                   3                                            3         |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                              3           3     3         |             
      Mesenteric, Angiectasis              |                            1                                             |             
      Mesenteric, Hyperplasia, Lymphoid    |       2  2                                                        2  1   |             
      Mesenteric, Hyperplasia              |                                                                2         |             
      Mesenteric, Inflammation, Suppurative|                                                          3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 5| 6| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 9| 3| 6| 3| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 7| 9| 3| 3| 0| 3|             
                                           | 1| 1| 1| 1| 5| 7| 1| 5| 6| 6| 8| 6| 6| 6| 6| 2| 6| 6| 6| 4| 6| 6| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hyperplasia                   |                                                          4               |             
      Renal, Inflammation, Suppurative     |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          | 3                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                2  3  3              3                 2     3  3        2|             
      Hyperplasia, Lymphoid                | 3     2  2                 2     2  3  1  3           2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                            2                                      3  1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |          2                                                  2            |             
      Hyperplasia                          |                                                             2            |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Metaplasia, Squamous           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1                                   1  1           1              1   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Distal, Joint, Femur, Arthrosis      |                                  2                                       |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                            3                                             |             
      Hemorrhage, Multifocal               |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |       1  1     2              1     1  1  1     1     2     1     1  1  1|             
      Infiltration Cellular, Mixed Cell    |                   2                          3                           |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Media, Hyperplasia           |                            1  1                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                          3               |             
      Vein, Intima, Mineralization         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 5| 6| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 9| 3| 6| 3| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 7| 9| 3| 3| 0| 3|             
                                           | 1| 1| 1| 1| 5| 7| 1| 5| 6| 6| 8| 6| 6| 6| 6| 2| 6| 6| 6| 4| 6| 6| 6| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                            1                          1                  |             
      Lumen, Foreign Body                  |                                                       1                  |             
      Mucosa, Angiectasis                  |                      2                                                   |             
      Mucosa, Hemorrhage                   |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                          +           +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic                |                                                                         2|             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |       2     2     1     1     1     1     1           1  4     4  1     1|             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3|             
                                           | 6| 6| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 8| 7| 7| 7| 7| 1| 7| 7| 8| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Hyperplasia, Lymphoid                | 1        1  1     1     1           1                          1         |             
      Infarct                              |                      4                                                   |             
      Infiltration Cellular, Mixed Cell    |                                           2                       2      |             
      Inflammation, Multifocal             | 1  1           1           1           1              1                 1|             
      Necrosis, Multifocal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +              +           +     +  +              +     +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                           2                       3      |             
      Fat, Necrosis                        | 2     2                                2                       2     2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    1                                                                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2                                                                  |             
      Inflammation, Focal                  |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
      Incisor, Dysplasia                   |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                   1      |             
      Artery, Media, Hyperplasia           |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3|             
                                           | 6| 6| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 8| 7| 7| 7| 7| 1| 7| 7| 8| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                      1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                1                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Bacterium             |                                                                   2      |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    1        1        1           1                 2  1        1         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                               1                 1                 1      |             
      Inflammation, Focal                  |    1                                                                     |             
      Follicular Cell, Hyperplasia         |       1  2     1        2              3                             1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation, Suppurative            |                                           4                       4      |             
      Follicle, Cyst                       |                            2                 3  2  1        3            |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                      +                                                   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                       3                  |             
      Inflammation, Suppurative            |                                                       3           4      |             
      Endometrium, Cyst                    |                         4                                                |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  2  3  2  3     3  3  3  2  4  3  3  3  3  3  3  3  3  4  3     3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |       2                                                                  |             
      Mediastinal, Hyperplasia             |                                           3                              |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                           3                       4      |             
      Mesenteric, Angiectasis              |                      1     2                 1                           |             
      Mesenteric, Hyperplasia, Lymphoid    |    2                                                                     |             
      Mesenteric, Hyperplasia              |                                                                   4      |             
      Mesenteric, Inflammation, Suppurative|                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3|             
                                           | 6| 6| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 8| 7| 7| 7| 7| 1| 7| 7| 8| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hyperplasia                   |                                           4                              |             
      Renal, Inflammation, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          2                                                  2            |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                1                                                         |             
      Fibrosis, Focal                      |                                                                         3|             
      Hematopoietic Cell Proliferation     |          2        3              2        4           2           3      |             
      Hyperplasia, Lymphoid                |                                                             3        3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2                                                     3        2  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |          1                                                           2   |             
      Hyperplasia                          |                                                                      2   |             
      Inflammation, Suppurative            |          2                                                               |             
      Duct, Metaplasia, Squamous           |          3                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1           1        2  1  1        1  2     1        1     1        1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Distal, Joint, Femur, Arthrosis      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage, Multifocal               |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                   3      |             
      Hemorrhage                           |                      4                             1                     |             
      Hyperplasia, Lymphoid                |             1                       2  1     1                           |             
      Infiltration Cellular, Mixed Cell    |                                           2                              |             
      Inflammation, Suppurative            |                                                                   3      |             
      Alveolar Epithelium, Hyperplasia     |                                                 2                        |             
      Artery, Media, Hyperplasia           |       2                                                                  |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Vein, Intima, Mineralization         |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3|             
                                           | 6| 6| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 8| 7| 7| 7| 7| 1| 7| 7| 8| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    UNTREATD                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                                                          |             
      Lumen, Foreign Body                  |                                                                          |             
      Mucosa, Angiectasis                  |                                                                          |             
      Mucosa, Hemorrhage                   |    2                                                                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                   2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                   2      |             
      Infiltration Cellular, Mixed Cell    |                                           2                              |             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Osseous                  |                                     1                                    |             
      Nephropathy                          | 2  1     1  1     2     1  1              1  2  2              1     2  1|             
      Renal Tubule, Mineralization         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  49        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |     14  1.0|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      4  2.0|
      Inflammation, Multifocal             |                                                                          |     17  1.0|
      Necrosis, Multifocal                 |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  17        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      6  3.3|
      Fat, Necrosis                        |                                                                          |      8  2.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  49        |
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  49        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      2  1.5|
      Inflammation, Focal                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Incisor, Dysplasia                   |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Artery, Media, Hyperplasia           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  49        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  48        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  49        |
      Cyst                                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  47        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Bacterium             |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      2  1.5|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |     13  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
      Degeneration, Cystic                 |                                                                          |      4  1.3|
      Inflammation, Focal                  |                                                                          |      3  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      8  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      8  3.9|
      Follicle, Cyst                       |                                                                          |     11  2.4|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   3        |
      Inflammation, Suppurative            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Hydrometra                           |                                                                          |      3  2.7|
      Inflammation, Suppurative            |                                                                          |      6  2.8|
      Endometrium, Cyst                    |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     44  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia             |                                                                          |      3  3.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      5  3.2|
      Mesenteric, Angiectasis              |                                                                          |      4  1.3|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      5  1.8|
      Mesenteric, Hyperplasia              |                                                                          |      2  3.0|
      Mesenteric, Inflammation, Suppurative|                                                                          |      2  2.5|
      Renal, Hyperplasia                   |                                                                          |      2  4.0|
      Renal, Inflammation, Suppurative     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  43        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Depletion Cellular                   |                                                                          |      1  1.0|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |     14  2.6|
      Hyperplasia, Lymphoid                |                                                                          |     11  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  47        |
      Hyperplasia, Lymphoid                |                                                                          |      7  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  49        |
      Dilatation                           |                                                                          |      4  1.8|
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Duct, Metaplasia, Squamous           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  49        |
      Inflammation, Chronic                |                                                                          |     16  1.1|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Distal, Joint, Femur, Arthrosis      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    UNTREATD                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Compression                          |                                                                          |      1  3.0|
      Hemorrhage, Multifocal               |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Bacterium                            |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |     17  1.2|
      Infiltration Cellular, Mixed Cell    |                                                                          |      3  2.3|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Artery, Media, Hyperplasia           |                                                                          |      3  1.3|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Vein, Intima, Mineralization         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Lumen, Exudate                       |                                                                          |      2  1.0|
      Lumen, Foreign Body                  |                                                                          |      1  1.0|
      Mucosa, Angiectasis                  |                                                                          |      1  2.0|
      Mucosa, Hemorrhage                   |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  49        |
      Bacterium                            |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy                          |                                                                          |     25  1.5|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|             
                                           | 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                 2                        |             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                 3                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                   1              3                                       |             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                          2               |             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Granulomatous                    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                        1                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                      2   |             
      Congestion                           |                                                          2               |             
      Fatty Change                         | 1              1                                                  2      |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Hyperplasia, Lymphoid                | 2  2                 1                       1           2              1|             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |             2              1                                             |             
      Inflammation, Multifocal             | 1     2     1           1           1        1     1  1        2  1      |             
      Necrosis, Multifocal                 |             1                       2                                    |             
      Pigmentation                         |                                                                          |             
      Hepatocyte, Erythrophagocytosis      |                               2                          2               |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Hyaline            |          2        2  2     1  2           1  1        1  1     1  1      |             
      Portal Vein, Media, Hyperplasia      |                                                          2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                   +     +     +            |             
      Edema                                |                                                 2                        |             
      Inflammation, Suppurative            |                                                                          |             
      Fat, Necrosis                        |                                                       3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |       4                                                                  |             
      Ectopic Tissue                       |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|             
                                           | 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinar Cell, Hypoplasia, Focal       |                                                                          |             
      Duct, Dilatation                     |       3                                                                  |             
      Duct, Dilatation, Multiple           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Mucosa, Hyperplasia, Papillary       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Focal                  |                                  1                                       |             
      Mineralization                       |                                                                          |             
      Epithelium, Degeneration, Hyaline    |                                        2                                 |             
      Epithelium, Metaplasia, Squamous     |                                  1                                       |             
      Mucosa, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                                                            |             
      Incisor, Dysplasia                   |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                1                                                         |             
      Amyloid Deposition                   |                                     1                                    |             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Focal                   |                                                                         3|             
      Inflammation, Suppurative            |                                                             2            |             
      Vacuolization Cytoplasmic, Focal     |                                                    2        1            |             
      Subcapsular, Hyperplasia, Focal      |                               2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                        1                                 |             
      Hyperplasia, Focal                   |                                                                1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    | 2  1                 1           2              1     2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                           1                          1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|             
                                           | 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Focal                  |                         1                                                |             
      C-Cell, Hyperplasia                  |                   2                                                      |             
      Follicular Cell, Hyperplasia         |          1                                         4              2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2              2               |             
      Atrophy                              |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage                           |                                           3                              |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                          3               |             
      Follicle, Cyst                       | 2                                         2                    1  3      |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                     +                                    |             
      Hyperplasia, Cystic                  |                                     3                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Hemorrhage                           |                2                                                         |             
      Hydrometra                           |                                              3  2           3            |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Cyst                    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  3  3  2  2        1  2  3  3  3  3  4  2  3  2  3  3  2  3  3  2  3  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia                   |                                                                          |             
      Inguinal, Hyperplasia                |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                              2        1                  |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Mesenteric, Angiectasis              |                                  1  1                                   1|             
      Mesenteric, Hyperplasia, Lymphoid    |                            2                 2        2  2        1     2|             
      Mesenteric, Hyperplasia              |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      2  3                             2  2              2|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          3                 3              3     4           3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|             
                                           | 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                      2                       3        2  2              2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   2                                                      |             
      Hyperplasia, Lymphoid                |                                              3     2     2        2     2|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 1           3     3                 2                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1     1     1                    1        1                              |             
      Subcutaneous Tissue, Edema           |                                                 3                        |             
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |             
           Lymphoid                        |                                                          2               |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                        2  2                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   4                                               2      |             
      Meninges, Hyperplasia, Lymphoid      |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1  2  3     1                    2           2           2     2        2|             
      Hyperplasia, Macrophage              |                         1                                                |             
      Infiltration Cellular, Mixed Cell    |                1                                                         |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |                         1                                                |             
      Artery, Inflammation                 |                2                                                         |             
      Artery, Media, Hyperplasia           |    1  2  2     2  2        1     2        2  2        2     2        2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                                          1               |             
      Lumen, Foreign Body                  |                                                          1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Cataract                             |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|             
                                           | 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retinal Detachment                   |                         3                                                |             
      Cornea, Inflammation                 |                         1                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Nephropathy                          | 1  1           1           1  1  1  2  1  1  1  2     1  1               |             
      Pelvis, Dilatation                   |                                                 2                        |             
      Renal Tubule, Degeneration, Hyaline  |                                                 3                        |             
      Renal Tubule, Dilatation             |                                     1                                    |             
      Renal Tubule, Pigmentation           |                   3                       2                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2                                      2                           |             
      Inflammation, Chronic                |                   3                                                      |             
      Ulcer                                |                   2                                                      |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                         2|             
      Lymphoid Tissue, Inflammation,       |                                                                          |             
          Granulomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                            2                                             |             
      Hyperplasia, Lymphoid                | 1              1                                1  2        1  1         |             
      Infarct                              |                                                                   4      |             
      Infiltration Cellular, Mixed Cell    |    2                                                                 2   |             
      Inflammation, Multifocal             |    2        1  1  1  1  1     2     2  2  1     1                 1  2  1|             
      Necrosis, Multifocal                 |                                                                          |             
      Pigmentation                         |                                        2                                 |             
      Hepatocyte, Erythrophagocytosis      |                                                                          |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Hyaline            |    2  1  2  2     1  1  1  2  2  1  1  1        1              1        1|             
      Portal Vein, Media, Hyperplasia      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                    +  +                                             |             
      Edema                                |                                                                          |             
      Inflammation, Suppurative            |    4                       4                                             |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                  2                                4      |             
      Ectopic Tissue                       |             2                                                            |             
      Hyperplasia, Lymphoid                |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinar Cell, Hypoplasia, Focal       |                3                                                         |             
      Duct, Dilatation                     |                                  2                                4      |             
      Duct, Dilatation, Multiple           |                3                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                             1     1      |             
      Mineralization                       |                                                                      1   |             
      Mucosa, Hyperplasia, Papillary       |                                                                   1      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1                                                                        |             
      Inflammation, Focal                  |                   2  2           1                                       |             
      Mineralization                       |                            1        1                                2   |             
      Epithelium, Degeneration, Hyaline    |                                                                         2|             
      Epithelium, Metaplasia, Squamous     |                                                                          |             
      Mucosa, Cyst                         |       2                             2                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +        +               |             
      Incisor, Dysplasia                   |                                                 2        1               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +   |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                      3   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis                          |                            3                                             |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Subcapsular, Hyperplasia, Focal      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                        1                                 |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |       1     1              1     1  1                       2     2     1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    2                                         1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Inflammation, Focal                  |                      2                 1                                 |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia         |       2     1  3  2  1              1  3     1        2  1        2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3                                                                  |             
      Atrophy                              |             3                                3                           |             
      Fibrosis, Focal                      |                                              3                           |             
      Hemorrhage                           |       2                                                                  |             
      Inflammation, Suppurative            |    4                       4                                         4   |             
      Mineralization                       |                                              3                           |             
      Follicle, Cyst                       |                      3              3     3     2  4                     |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       3                  |             
      Hemorrhage                           |                                                       3                  |             
      Hydrometra                           |                                                          3               |             
      Inflammation, Suppurative            |    2                                                           2     2   |             
      Endometrium, Cyst                    |                                        3  3                              |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  3  2  2  3  3  2  3  1  3  3  3  3  3     3  3  3  3  3  3  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |    3                                                                 3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia                   |    3                                                                     |             
      Inguinal, Hyperplasia                |    2                                                                     |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia             |    2                                                                     |             
      Mesenteric, Angiectasis              |             1  2                                            1            |             
      Mesenteric, Hyperplasia, Lymphoid    |                   2                                                      |             
      Mesenteric, Hyperplasia              |    2                                                                 2   |             
      Renal, Hyperplasia                   |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         3|             
      Hyperplasia                          |    2                                                                 2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4  2     3           3  4           3                       2     3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                | 2  2           2     2                             3     2     2  2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                | 1                                                                        |             
      Hyperplasia                          |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                2                          2                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    3  1                                1     1                       1  1|             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |             
           Lymphoid                        |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                         2                                                |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                         2                                                |             
      Meninges, Hyperplasia, Lymphoid      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2  2  2        2                 1  1           2  2     2  1     2  2   |             
      Hyperplasia, Macrophage              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Mineralization                       |                               1                                          |             
      Pigmentation                         |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Artery, Media, Hyperplasia           | 2  1                          1  1        1     1  1  1           2  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                                                          |             
      Lumen, Foreign Body                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retinal Detachment                   |                                                                          |             
      Cornea, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    2                     |             
      Infiltration Cellular, Mixed Cell    |                                                                      2   |             
      Nephropathy                          | 1  2  3     1           1  2     1     1     1  1  1     1     1  3  2   |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Degeneration, Hyaline  |    2                                                                     |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           2        1              2      |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  49        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
      Edema                                |                                                                          |      1  2.0|
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  50        |
      Edema                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
      Amyloid Deposition                   |                                                                          |      2  2.0|
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      2  2.0|
      Lymphoid Tissue, Inflammation,       |                                                                          |            |
          Granulomatous                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
      Amyloid Deposition                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus                     |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Fatty Change                         |                                                                          |      3  1.3|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |     12  1.3|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      4  1.8|
      Inflammation, Multifocal             |                                                                          |     24  1.3|
      Necrosis, Multifocal                 |                                                                          |      2  1.5|
      Pigmentation                         |                                                                          |      1  2.0|
      Hepatocyte, Erythrophagocytosis      |                                                                          |      2  2.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration, Hyaline            |                                                                          |     26  1.3|
      Portal Vein, Media, Hyperplasia      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Atrophy, Focal                       |                                                                          |      3  3.3|
      Ectopic Tissue                       |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Acinar Cell, Hypoplasia, Focal       |                                                                          |      1  3.0|
      Duct, Dilatation                     |                                                                          |      3  3.0|
      Duct, Dilatation, Multiple           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Inflammation, Focal                  |                                                                          |      2  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Mucosa, Hyperplasia, Papillary       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Inflammation, Focal                  |                                                                          |      4  1.5|
      Mineralization                       |                                                                          |      3  1.3|
      Epithelium, Degeneration, Hyaline    |                                                                          |      2  2.0|
      Epithelium, Metaplasia, Squamous     |                                                                          |      1  1.0|
      Mucosa, Cyst                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
      Incisor, Dysplasia                   |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  1.0|
      Amyloid Deposition                   |                                                                          |      1  1.0|
      Angiectasis                          |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Subcapsular, Hyperplasia, Focal      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Ectopic Tissue                       |                                                                          |      2  1.0|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  47        |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |     14  1.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Degeneration, Cystic                 |                                                                          |      4  1.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Focal                  |                                                                          |      3  1.3|
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |     14  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  48        |
      Angiectasis                          |                                                                          |      3  2.3|
      Atrophy                              |                                                                          |      2  3.0|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      3  4.0|
      Mineralization                       |                                                                          |      2  3.0|
      Follicle, Cyst                       |                                                                          |      9  2.6|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Angiectasis                          |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      2  2.5|
      Hydrometra                           |                                                                          |      4  2.8|
      Inflammation, Suppurative            |                                                                          |      3  2.0|
      Endometrium, Cyst                    |                                                                          |      2  3.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     47  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Neutrophil              |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Iliac, Hyperplasia                   |                                                                          |      1  3.0|
      Inguinal, Hyperplasia                |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  1.5|
      Mediastinal, Hyperplasia             |                                                                          |      1  2.0|
      Mesenteric, Angiectasis              |                                                                          |      6  1.2|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      7  1.9|
      Mesenteric, Hyperplasia              |                                                                          |      2  2.0|
      Renal, Hyperplasia                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      6  2.3|
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |     13  3.1|
      Hyperplasia, Lymphoid                |                                                                          |     13  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  47        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  50        |
      Dilatation                           |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |     11  1.2|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |            |
           Lymphoid                        |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Cranium, Hyperostosis                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Compression                          |                                                                          |      3  2.7|
      Meninges, Hyperplasia, Lymphoid      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Hyperplasia, Lymphoid                |                                                                          |     21  1.8|
      Hyperplasia, Macrophage              |                                                                          |      1  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Artery, Inflammation                 |                                                                          |      1  2.0|
      Artery, Media, Hyperplasia           |                                                                          |     23  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Lumen, Exudate                       |                                                                          |      1  1.0|
      Lumen, Foreign Body                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  2.0|
      Retinal Detachment                   |                                                                          |      1  3.0|
      Cornea, Inflammation                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Nephropathy                          |                                                                          |     28  1.3|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      2  2.5|
      Renal Tubule, Dilatation             |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      5  1.8|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  2.0|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 1| 6| 6| 6| 1| 6| 6| 6| 4| 6| 6| 6| 6| 7| 8| 9| 0| 6| 6| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +           +           +              +  +  +  +                  |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +           +           +              +  +  +  +                  |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fatty Change                         |       2                                                     2            |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                 3                        |             
      Hyperplasia, Lymphoid                |    2  2        1     1              1  1                       1        2|             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    | 1                                               2                       2|             
      Inflammation, Multifocal             |    1        1        1     1              1  1           1     1  1  1  1|             
      Mineralization                       |                                                                          |             
      Necrosis, Multifocal                 |       2                                                                  |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Hyaline            |                   1                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +     +     +                 +  +                    +|             
      Cyst                                 |                         2                                                |             
      Inflammation, Suppurative            |                   2                             3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +        +           +              +  +  +  +                  |             
      Inflammation, Suppurative            |                                                 3                        |             
      Duct, Dilatation                     |          4                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +           +           +              +  +  +  +                  |             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Dysplasia                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +           +           +              +  +  +  +                  |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 1| 6| 6| 6| 1| 6| 6| 6| 4| 6| 6| 6| 6| 7| 8| 9| 0| 6| 6| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +           +           +              +  +  +  +                  |             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       M           +           M              +  M  M  +                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +           +           +              +  +  +  +           +      |             
      Pars Distalis, Focal Cellular Change |                               1                 1                        |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Nervosa, Inflammation, Focal    |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                    1                     |             
      Inflammation, Focal                  |             1           1                                   1            |             
      C-Cell, Hyperplasia                  |                                     1                                    |             
      Follicular Cell, Hyperplasia         | 1     1  1  1        1  1  2              2           1  1  1     3     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abdominal, Infiltration Cellular,    |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +           +                             +  +  +     +            |             
      Granuloma                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                   4                             4                        |             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                                                          |             
      Inflammation, Suppurative            |                                  1                    1                  |             
      Endometrium, Hyperplasia, Cystic     | 3  4  3     3  3  1     3  3  2  3  2  3     2  2  3  3  3  1  3  3  3  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +           +           +              +  +  +  +                  |             
      Hyperplasia, Neutrophil              |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +           +           +           +  +  +  +  +                  |             
      Iliac, Hyperplasia                   |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Hyperplasia             |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 1| 6| 6| 6| 1| 6| 6| 6| 4| 6| 6| 6| 6| 7| 8| 9| 0| 6| 6| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                    2                     |             
      Mesenteric, Hyperplasia              |                                                                          |             
      Pancreatic, Hyperplasia              |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +           +           +           +  M  +  +  +                  |             
      Hyperplasia, Lymphoid                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +        +     +     +              +  +  +  +                 +|             
      Hematopoietic Cell Proliferation     | 3     3           3     3                       3  3                    3|             
      Hyperplasia, Lymphoid                |       2  2                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +           +           +              +  +  +  +                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +           +           +              +  +  +  +                  |             
      Dilatation                           |                                                       2                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +  +         |             
      Inflammation, Chronic                |                         1        1                             1         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +           +           +              +  +  +  +                  |             
      Compression                          |                                                       4                  |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mixed Cell                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                         1                       2              1         |             
      Hyperplasia, Lymphoid                |          1     2     1  1              1  1              1  1            |             
      Hyperplasia, Macrophage              |                         2                          3                     |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Granulomatous          |                                                             1            |             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Media, Hyperplasia           |          1     2              1     1     1                              |             
      Bronchiole, Bronchiectasis           |                1                                                         |             
      Bronchiole, Epithelium, Hyperplasia  |                1                                                         |             
      Mediastinum, Inflammation,           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 1| 6| 6| 6| 1| 6| 6| 6| 4| 6| 6| 6| 6| 7| 8| 9| 0| 6| 6| 6| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Suppurative                      |                                                 3                        |             
                                            __________________________________________________________________________|             
   Nose                                    |       +           +           +              +  +  +  +                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +           +           +              +  +  +  +                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                 3                        |             
      Metaplasia, Osseous                  |                      1                                                   |             
      Nephropathy                          |    1  1  1     1  3  1  2  1     1     1        2  2  1  1     1     1  1|             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +           +           +              +  +  +  +                  |             
      Inflammation, Chronic                |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 6| 7| 6| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 3| 7| 3| 0| 3| 1| 3| 3| 6| 0| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 6| 3| 4|             
                                           | 7| 9| 7| 0| 8| 1| 7| 7| 5| 8| 7| 7| 8| 5| 0| 7| 4| 8| 2| 0| 8| 8| 5| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +     +        +  A        A  +  +     +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +     +        +  A        A  +  +     +     A  A        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +     +        +  A        A  +  +     +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +     +        +  A        A  +  +     +     A  A        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +     +        +  A        A  +  +     +     A  A        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +     +        +  A        A  +  +     +     A  A        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +     +        +  A        A  +  +     +     A  A        +     +|             
      Dilatation                           |                                                                   3      |             
      Inflammation, Chronic                |                                                                   4      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +     +        +  A        A  +  +     +     A  A        +     +|             
      Dilatation                           |                                                                   3      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fatty Change                         |                                                                          |             
      Fibrosis                             |                                                    3                     |             
      Hematopoietic Cell Proliferation     |                         3  3        2     2  1           2               |             
      Hyperplasia, Lymphoid                | 2                    1        1  1                 2     1  1        2   |             
      Infarct                              |                                                    3                     |             
      Infiltration Cellular, Mixed Cell    |    1                       2        2  3  2     2        3              1|             
      Inflammation, Multifocal             | 2     1           1                          1     2           1  1      |             
      Mineralization                       |                                                    3                     |             
      Necrosis, Multifocal                 |                                                                          |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Hyaline            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                    +  +        +  +  +           +  +              +|             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |    3                       4        4  3  3              4              3|             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +     +        +  A        +  +  +     +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +     +        +  A        +  +  +     +     +  +        +     +|             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +     +        +  A        +  +  +     +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
      Incisor, Dysplasia                   |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
      Infiltration Cellular, Mixed Cell    |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 6| 7| 6| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 3| 7| 3| 0| 3| 1| 3| 3| 6| 0| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 6| 3| 4|             
                                           | 7| 9| 7| 0| 8| 1| 7| 7| 5| 8| 7| 7| 8| 5| 0| 7| 4| 8| 2| 0| 8| 8| 5| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +     +        M  +        +  +  +     +     +  +        +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +     +     +  +  M        +  +  +     +     +  +  +     +     +|             
      Pars Distalis, Focal Cellular Change |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                1                                         2               |             
      Pars Nervosa, Inflammation, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                           1                       1  2   |             
      Inflammation, Focal                  |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia         |       1  2  2           1     1  2     1                       2  2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                      +   |             
      Abdominal, Infiltration Cellular,    |                                                                          |             
           Lymphocyte                      |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +     +     +  +     +  +  +     +  +  +  +  +  +  +  +        +  +  +|             
      Granuloma                            |                   3                                                      |             
      Hyperplasia, Lymphoid                |                   3                                                      |             
      Inflammation, Chronic                |                   3                                                      |             
      Inflammation, Suppurative            |    4                       4        4  4  4              4              4|             
      Follicle, Cyst                       |    3     1              3     3              3     2              4  3   |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                     +  +  +                             +|             
      Inflammation, Suppurative            |                                     3  3  4                             3|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Angiectasis                          |                                                          3               |             
      Hemorrhage                           |                4                                                         |             
      Hydrometra                           |                   3                                            2         |             
      Inflammation, Suppurative            |                                           2              2              2|             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  2  4  3  3           3  3  3  2  3  3  3     3     2  3        3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
      Iliac, Hyperplasia                   |                            3        3     3              3               |             
      Inguinal, Hyperplasia, Lymphoid      |                                                 3                        |             
      Mediastinal, Hyperplasia             |                            3              3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 6| 7| 6| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 3| 7| 3| 0| 3| 1| 3| 3| 6| 0| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 6| 3| 4|             
                                           | 7| 9| 7| 0| 8| 1| 7| 7| 5| 8| 7| 7| 8| 5| 0| 7| 4| 8| 2| 0| 8| 8| 5| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                                          3               |             
      Mesenteric, Hyperplasia, Lymphoid    |                                           2                              |             
      Mesenteric, Hyperplasia              |                            3        3                                    |             
      Pancreatic, Hyperplasia              |                            4                                             |             
      Renal, Hyperplasia                   |                            4        3  3  3              3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +     +        +  +        +  +  +     +     M  +        +     +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +     +  +  M        +  +  +  +  +     +  +  +     +     +|             
      Hematopoietic Cell Proliferation     |    3     3  3  3        3           3  3  4     2        3  3     2     3|             
      Hyperplasia, Lymphoid                |          3                                   2  2           2            |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +     +        +  M        M  +  +     +     +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +     +|             
      Inflammation, Chronic                |             2        1                             1                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
      Inflammation, Suppurative            |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
      Compression                          |                                                                          |             
      Artery, Inflammation, Chronic        |                                                       2                  |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mixed Cell                      |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                       2                  |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                | 2                    2     2  1  2                 1        2            |             
      Hyperplasia, Macrophage              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                            3        2                    4               |             
      Inflammation, Granulomatous          |       1                                                                  |             
      Inflammation, Suppurative            |                                        3                                 |             
      Artery, Media, Hyperplasia           | 1                 1     2  1                       1                     |             
      Bronchiole, Bronchiectasis           |                                                                          |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 6| 7| 6| 7| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 3| 7| 3| 0| 3| 1| 3| 3| 6| 0| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 6| 3| 4|             
                                           | 7| 9| 7| 0| 8| 1| 7| 7| 5| 8| 7| 7| 8| 5| 0| 7| 4| 8| 2| 0| 8| 8| 5| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Suppurative                      |                                           3              3               |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Atrophy                              |                                                                      4   |             
      Fibrosis                             |                                                                      3   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                           +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    2                                                                     |             
      Metaplasia, Osseous                  |          1                                   1                           |             
      Nephropathy                          |    3  1  2  1     1     1     1  1  2  2        1  2        2  1     2  3|             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +     +        +  +        +  +  +     +     +  +        +     +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 8| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  21        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                                                                        |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                                                                        |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M                                                                        |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +                                                                        |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M                                                                        |  16        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | M                                                                        |  16        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Fatty Change                         |                                                                          |      2  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      7  2.3|
      Hyperplasia, Lymphoid                |                                                                          |     16  1.4|
      Infarct                              |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |     11  1.9|
      Inflammation, Multifocal             | 1                                                                        |     19  1.1|
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration, Hyaline            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  15        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      9  3.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  22        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Duct, Dilatation                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  21        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                                                                        |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  20        |
      Inflammation, Focal                  | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  20        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Incisor, Dysplasia                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 8| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  21        |
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                                                                        |  21        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                                                                        |  21        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                                                                        |  21        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  21        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M                                                                        |  14        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  23        |
      Pars Distalis, Focal Cellular Change |                                                                          |      2  1.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      2  1.5|
      Pars Nervosa, Inflammation, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      Degeneration, Cystic                 |                                                                          |      4  1.3|
      Inflammation, Focal                  |                                                                          |      3  1.0|
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |     22  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Abdominal, Infiltration Cellular,    |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  25        |
      Granuloma                            |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      9  4.0|
      Follicle, Cyst                       |                                                                          |      8  2.8|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   4        |
      Inflammation, Suppurative            |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  45        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydrometra                           |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 8| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      5  1.6|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     40  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  21        |
      Hyperplasia, Neutrophil              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |  22        |
      Iliac, Hyperplasia                   |                                                                          |      4  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia             |                                                                          |      3  2.7|
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      2  2.0|
      Mesenteric, Hyperplasia              |                                                                          |      2  3.0|
      Pancreatic, Hyperplasia              |                                                                          |      1  4.0|
      Renal, Hyperplasia                   |                                                                          |      5  3.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  20        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  28        |
      Hematopoietic Cell Proliferation     |                                                                          |     20  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  19        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  21        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  40        |
      Inflammation, Chronic                |                                                                          |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  21        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  21        |
      Compression                          |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 8| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
           Mixed Cell                      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Congestion                           | 2                                                                        |      2  2.0|
      Hemorrhage                           | 3                                                                        |      4  1.8|
      Hyperplasia, Lymphoid                |                                                                          |     15  1.4|
      Hyperplasia, Macrophage              |                                                                          |      2  2.5|
      Infiltration Cellular, Mixed Cell    |                                                                          |      3  3.0|
      Inflammation, Granulomatous          |                                                                          |      2  1.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Artery, Media, Hyperplasia           |                                                                          |     10  1.2|
      Bronchiole, Bronchiectasis           |                                                                          |      1  1.0|
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |      1  1.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  21        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  21        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Atrophy                              |                                                                          |      1  4.0|
      Fibrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  50        |
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Metaplasia, Osseous                  |                                                                          |      3  1.0|
      Nephropathy                          |                                                                          |     33  1.5|
      Renal Tubule, Dilatation             | 1                                                                        |      1  1.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  21        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 5| 5| 7| 4| 7| 5| 7| 7| 6| 5| 7| 7| 6|             
                             DAY ON TEST   | 8| 3| 3| 9| 3| 3| 6| 3| 3| 3| 3| 7| 4| 3| 3| 7| 3| 6| 1| 3| 4| 5| 3| 3| 9|             
                                           | 8| 6| 6| 6| 6| 6| 3| 6| 6| 9| 6| 9| 3| 5| 6| 2| 6| 1| 8| 6| 4| 4| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +        +        +     +  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +        +        +        +     A  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +        +        +     A  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +        +        +     A  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +        +        +     A  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +        +        +     A  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +        +        +     A  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +        +        +     A  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +        +        +     A  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +        +        +     A  +  +     +     +  +     +  +        +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                        3                                 |             
      Congestion                           |                                                       4                  |             
      Cyst                                 |       4                                                                  |             
      Hematopoietic Cell Proliferation     |                                        3              3        3         |             
      Hyperplasia, Lymphoid                |          2              2  1              1     1                        |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    | 1                                      2     2        4        3         |             
      Inflammation, Multifocal             |                         1                                1        1      |             
      Necrosis, Multifocal                 |                                  1                                       |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                +     +              +        +         |             
      Inflammation, Suppurative            |                                        3              3        3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +        +        +     +  +  +     A     +  +     +  +        +|             
      Atrophy, Diffuse                     |                                                                          |             
      Atrophy, Focal                       |                                                                          |             
      Inflammation, Suppurative            |                                        2                                 |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +        +        +     +  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +        +        +     +  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +        +        +     +  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +        +        +     +  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +  +                  |             
      Incisor, Dysplasia                   |                                                    1  2                  |             
      Incisor, Inflammation, Suppurative   |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                       +                  |             
      Aorta, Thrombosis                    |                                                       4                  |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +        +        +     +  +  +     +     +  +     +  +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 5| 5| 7| 4| 7| 5| 7| 7| 6| 5| 7| 7| 6|             
                             DAY ON TEST   | 8| 3| 3| 9| 3| 3| 6| 3| 3| 3| 3| 7| 4| 3| 3| 7| 3| 6| 1| 3| 4| 5| 3| 3| 9|             
                                           | 8| 6| 6| 6| 6| 6| 3| 6| 6| 9| 6| 9| 3| 5| 6| 2| 6| 1| 8| 6| 4| 4| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +        +        +     +  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +        +        +     +  +  +     +     +  +     +  +        +|             
      Focal Cellular Change                |                                  2                                       |             
      Infiltration Cellular, Mixed Cell    |                                                       3                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +        +        +     +  +  +     +     +  +     +  +        +|             
      Hyperplasia, Focal                   |                                                    2                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +        +        +     +  +  +     A     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        M        +        +     +  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +        +        +     +  +  +     +     +  +     +  +        +|             
      Pars Distalis, Focal Cellular Change |                                        2                                 |             
      Pars Distalis, Necrosis, Focal       |                                     1                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 1  1                          1                                         2|             
      Follicular Cell, Hyperplasia         |                      1  3                                1  2        1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
      Abdominal, Foreign Body              | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +        +        +     +  +  +  +  +     +  +     +  +        +|             
      Angiectasis                          | 2                          2                                             |             
      Hemorrhage                           |                            4                                             |             
      Inflammation, Suppurative            |                   4                    4     4        4        4         |             
      Thrombosis                           |                            4                                             |             
      Follicle, Cyst                       |    3                       3                                             |             
      Follicle, Cyst, Multiple             |                                           3                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            2        3                                    |             
      Hemorrhage                           |                            4                                             |             
      Hydrometra                           |                3           3        4                                    |             
      Inflammation, Suppurative            |                   2                 3  1     3                    2      |             
      Thrombosis                           |                                     2                                    |             
      Endometrium, Hyperplasia, Cystic     | 2  3  2  2  3  3  2  3  3  4           2  3     3     2  4  2  3  3  3  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +        +        +     +  +  +     +     +  +     +  +        +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +        +        +     +  +  +     +     +  +     +  +        +|             
      Iliac, Hyperplasia                   |                                                                          |             
      Mediastinal, Angiectasis             |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 5| 5| 7| 4| 7| 5| 7| 7| 6| 5| 7| 7| 6|             
                             DAY ON TEST   | 8| 3| 3| 9| 3| 3| 6| 3| 3| 3| 3| 7| 4| 3| 3| 7| 3| 6| 1| 3| 4| 5| 3| 3| 9|             
                                           | 8| 6| 6| 6| 6| 6| 3| 6| 6| 9| 6| 9| 3| 5| 6| 2| 6| 1| 8| 6| 4| 4| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                3         |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                3         |             
      Mesenteric, Angiectasis              | 2  2                                                                     |             
      Mesenteric, Hyperplasia              |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
      Renal, Inflammation, Suppurative     |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +        +        +     +  +  +     +     +  +     +  +        +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +     +  +     +  +     +  +  +     +     +  +     +  +        +|             
      Hematopoietic Cell Proliferation     |                         3  3        2  3              3     2  3        3|             
      Hyperplasia, Lymphoid                |                3                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +        +        +     A  +  +     +     +  +     +  +        +|             
      Cyst                                 |          1                                                               |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +        +        +     +  +  +     +     +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +|             
      Inflammation, Chronic                |                                     1                                1   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +        +        +     +  +  +     +     +  +     +  +        +|             
      Femur, Hyperostosis                  |                                                       3                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +        +        +     +  +  +     +     +  +     +  +        +|             
      Compression                          |                                                             3            |             
      Gliosis                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Artery, Meninges, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              3                           |             
      Hyperplasia, Lymphoid                | 1     1  3  2                          2              2                  |             
      Hyperplasia, Macrophage              |          4                                                               |             
      Infiltration Cellular, Mixed Cell    |                                                       3                  |             
      Artery, Media, Hyperplasia           |             2           1              2              2                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +        +        +     +  +  +     +     +  +     +  +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 5| 5| 7| 4| 7| 5| 7| 7| 6| 5| 7| 7| 6|             
                             DAY ON TEST   | 8| 3| 3| 9| 3| 3| 6| 3| 3| 3| 3| 7| 4| 3| 3| 7| 3| 6| 1| 3| 4| 5| 3| 3| 9|             
                                           | 8| 6| 6| 6| 6| 6| 3| 6| 6| 9| 6| 9| 3| 5| 6| 2| 6| 1| 8| 6| 4| 4| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +        +        +     +  +  +     +     +  +     +  +        +|             
      Artery, Peritracheal Tissue,         |                                                                          |             
          Inflammation, Chronic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                        1                                 |             
      Infiltration Cellular, Mixed Cell    |                                                       3                  |             
      Inflammation, Suppurative            |                                        3              2                  |             
      Metaplasia, Osseous                  |                                     1                                    |             
      Necrosis, Multifocal                 |                                                       2                  |             
      Nephropathy                          |    2  1  2        1                       1        1                     |             
      Capsule, Inflammation, Suppurative   |                                                                          |             
      Renal Tubule, Degeneration, Hyaline  |                                                                         1|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +        +        +     +  +  +     A     +  +     +  +        +|             
      Transitional Epithelium, Hyperplasia | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 9| 1| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 5| 6| 6| 7| 7| 4| 2| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +              +  +  +     M           +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +              M  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +              +  +  +     +           +                          +   |             
      Amyloid Deposition                   |                         3                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               3                                          |             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                         2           4                             3      |             
      Hyperplasia, Lymphoid                |       2     1  2  1        1        2  1     1        1                  |             
      Infarct                              |                                                                3         |             
      Infiltration Cellular, Mixed Cell    |    2                    2           2     1                       2      |             
      Inflammation, Multifocal             |       2           1  1                             1           1     2  1|             
      Necrosis, Multifocal                 |                                                                      2   |             
      Bile Duct, Hyperplasia               |             1                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                         +      |             
      Inflammation, Suppurative            |                         3                                         3      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +        +     +  +  +     +     +     +                          +   |             
      Atrophy, Diffuse                     |             4                       4                                    |             
      Atrophy, Focal                       |                      2                                                   |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |                                     3                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +  +                                                   |             
      Incisor, Dysplasia                   |                   1  1                                                   |             
      Incisor, Inflammation, Suppurative   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                           +                              |             
      Aorta, Thrombosis                    |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                           2                              |             
                                            __________________________________________________________________________|             
   Heart                                   |    +              +  +  +     +           +                          +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 9| 1| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 5| 6| 6| 7| 7| 4| 2| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +              +  +  +     +           +                          +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +              +  +  +     +           +                          +  +|             
      Focal Cellular Change                |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +              +  +  +     +           +                          +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +              +  +  +     +           +                          M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +              +  +  +     +           +           +  +           +   |             
      Pars Distalis, Focal Cellular Change |                      1                                                   |             
      Pars Distalis, Necrosis, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                      1                    1                              |             
      Follicular Cell, Hyperplasia         | 1           2  1                 1  1  2     1  1  1        1  2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
      Abdominal, Foreign Body              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +              +  +  +     +     +     +     +                 +  +   |             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                      4  4           4                             4  3   |             
      Thrombosis                           |                                                                          |             
      Follicle, Cyst                       |                                                 3                 3  2   |             
      Follicle, Cyst, Multiple             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +     +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Angiectasis                          |             2                                               4            |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                                                2         |             
      Inflammation, Suppurative            |                                     3                             2      |             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    3  2     3     2  2  2  3  3  3  3  3     3  3  3     4  4  3  3  2  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                         +                                                |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +              +  +  +     +           +                          +   |             
      Hyperplasia, Neutrophil              |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +        +  +  +     +  +  +     +                          +   |             
      Iliac, Hyperplasia                   |                                     3                                    |             
      Mediastinal, Angiectasis             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 9| 1| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 5| 6| 6| 7| 7| 4| 2| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |          2        3                                                      |             
      Mediastinal, Hyperplasia             |                         3           3                                    |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Mesenteric, Angiectasis              |                                                                          |             
      Mesenteric, Hyperplasia              |                         3                                                |             
      Renal, Hyperplasia                   |                         3                                                |             
      Renal, Inflammation, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +              +  +  +     +  +        +                          +   |             
      Hyperplasia, Lymphoid                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +           +  +  +  +     +  +  +     +        +  +           +  +   |             
      Hematopoietic Cell Proliferation     |                         3     3     4                             3      |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +              +  +  +     +           +                          +   |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +              +  +  +     +           +                          +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +     +     +  +  +|             
      Inflammation, Chronic                |    2           1                                      2                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +              +  +  +     +           +                          +   |             
      Femur, Hyperostosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +              +  +  +     +           +                          +   |             
      Compression                          |                                                                          |             
      Gliosis                              |                   2                                                      |             
      Infiltration Cellular, Lymphocyte    |                                           1                              |             
      Necrosis, Focal                      |                   2                                                      |             
      Artery, Meninges, Inflammation,      |                                                                          |             
          Chronic                          |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   3                                                      |             
      Hyperplasia, Lymphoid                | 1     2        2  2        1        1        1  2     1        1         |             
      Hyperplasia, Macrophage              |                3                                                         |             
      Infiltration Cellular, Mixed Cell    |                         2           1                                    |             
      Artery, Media, Hyperplasia           | 2     2                       1              1        1        1         |             
                                            __________________________________________________________________________|             
   Nose                                    |    +              +  +  +     +           +                          +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 9| 1| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 5| 6| 6| 7| 7| 4| 2| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 3| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +              +  +  +     +           +                          +   |             
      Artery, Peritracheal Tissue,         |                                                                          |             
          Inflammation, Chronic            |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                         2                                                |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Nephropathy                          | 1     1     1  1     4  3           2  1     1  1     1     1  2        1|             
      Capsule, Inflammation, Suppurative   |                         2                                                |             
      Renal Tubule, Degeneration, Hyaline  |                         2     2                                          |             
      Renal Tubule, Hyperplasia            |          3                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +              +  +  +     +           +                          +   |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  19        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                          |      6  3.0|
      Hyperplasia, Lymphoid                |                                                                          |     14  1.4|
      Infarct                              |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |     10  2.1|
      Inflammation, Multifocal             |                                                                          |     10  1.2|
      Necrosis, Multifocal                 |                                                                          |      2  1.5|
      Bile Duct, Hyperplasia               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Inflammation, Suppurative            |                                                                          |      5  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  21        |
      Atrophy, Diffuse                     |                                                                          |      2  4.0|
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
      Incisor, Dysplasia                   |                                                                          |      4  1.3|
      Incisor, Inflammation, Suppurative   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Aorta, Thrombosis                    |                                                                          |      1  4.0|
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  20        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  21        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  21        |
      Focal Cellular Change                |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  21        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  19        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  22        |
      Pars Distalis, Focal Cellular Change |                                                                          |      2  1.5|
      Pars Distalis, Necrosis, Focal       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Degeneration, Cystic                 |                                                                          |      6  1.2|
      Follicular Cell, Hyperplasia         |                                                                          |     16  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Abdominal, Foreign Body              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  25        |
      Angiectasis                          |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |     10  3.9|
      Thrombosis                           |                                                                          |      1  4.0|
      Follicle, Cyst                       |                                                                          |      5  2.8|
      Follicle, Cyst, Multiple             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  45        |
      Angiectasis                          |                                                                          |      4  2.8|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydrometra                           |                                                                          |      4  3.0|
      Inflammation, Suppurative            |                                                                          |      7  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis                           |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     40  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  20        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  24        |
      Iliac, Hyperplasia                   |                                                                          |      1  3.0|
      Mediastinal, Angiectasis             |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.5|
      Mediastinal, Hyperplasia             |                                                                          |      3  3.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Mesenteric, Angiectasis              |                                                                          |      2  2.0|
      Mesenteric, Hyperplasia              |                                                                          |      1  3.0|
      Renal, Hyperplasia                   |                                                                          |      1  3.0|
      Renal, Inflammation, Suppurative     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  21        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  29        |
      Hematopoietic Cell Proliferation     |                                                                          |     12  2.9|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  19        |
      Cyst                                 |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  43        |
      Inflammation, Chronic                |                                                                          |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  20        |
      Femur, Hyperostosis                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  20        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Compression                          |                                                                          |      1  3.0|
      Gliosis                              |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Artery, Meninges, Inflammation,      |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |     16  1.6|
      Hyperplasia, Macrophage              |                                                                          |      2  3.5|
      Infiltration Cellular, Mixed Cell    |                                                                          |      3  2.0|
      Artery, Media, Hyperplasia           |                                                                          |     10  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  20        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  20        |
      Artery, Peritracheal Tissue,         |                                                                          |            |
          Inflammation, Chronic            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Bacterium                            |                                                                          |      1  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Nephropathy                          |                                                                          |     20  1.5|
      Capsule, Inflammation, Suppurative   |                                                                          |      1  2.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      3  1.7|
      Renal Tubule, Hyperplasia            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  19        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|             
                                           | 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              3                           |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         3|             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                   2      |             
      Focal Cellular Change                |    1                                                                     |             
      Hyperplasia, Lymphoid                |                               1  1                                       |             
      Hyperplasia, Multifocal              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |             1  2                                            3            |             
      Inflammation, Multifocal             |       1           1              1     1  1                              |             
      Necrosis, Multifocal                 |       1     1  2                 1           2     1        1            |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |             2                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +              +  +                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                    2                     |             
      Focal Cellular Change                |                                                                          |             
      Necrosis, Focal                      |                                                    2                     |             
      Duct, Degeneration, Hyaline          |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
      Duct, Hyperplasia, Papillary         |                                                                          |             
      Duct, Metaplasia                     |                                                                          |             
      Vein, Infiltration Cellular, Mixed   |                                                                          |             
          Cell                             |                                              1                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |       3                                                                  |             
      Fibrosis, Focal                      |       3                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               2                                          |             
      Mucosa, Hyperplasia, Papillary       |                   2           2                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|             
                                           | 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Focal                  |                                                                   1      |             
      Mineralization                       |                                                                          |             
      Epithelium, Metaplasia, Squamous     |                                                                          |             
      Mucosa, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +     +              +     +  +     +  +                 +               |             
      Incisor, Dysplasia                   | 2     2              1     2  3     1  3                                 |             
      Incisor, Inflammation, Chronic       |                               3                                          |             
      Incisor, Inflammation, Suppurative   |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                    1  1                  |             
      Inflammation, Suppurative            |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Extra Adrenal Tissue, Fibrosis       |                                                                          |             
      Subcapsular, Hyperplasia, Focal      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                            2                                             |             
      Degeneration, Cystic                 |                         1                 1     1     2  1        1      |             
      Inflammation, Focal                  |                               1                                          |             
      Follicular Cell, Hyperplasia         |                         1                             2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |             +  +                                                        +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|             
                                           | 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                4                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                 +     +        +     +        +              +|             
      Degeneration, Cystic                 |                            3     3              4        2              3|             
      Inflammation, Suppurative            |          3                                4              2              3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                2                                            3            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                2                 3     2                                 |             
      Inflammation, Chronic                |                2                 3                          3            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Germinal Epithelium, Degeneration    |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Neutrophilia                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia                   |                3                                                         |             
      Inguinal, Hyperplasia                |                2                                                         |             
      Inguinal, Inflammation, Chronic      |                               4                                          |             
      Mesenteric, Angiectasis              | 1     3        2        2  3  1  3        1                       2      |             
      Mesenteric, Depletion Lymphoid       |                                              2                           |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Depletion Lymphoid                   |                                              2                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                                                            |             
      Depletion Cellular                   |                                                                      2   |             
      Hematopoietic Cell Proliferation     |                   3        2  2  3        3  3     3  4     3            |             
      Hyperplasia, Lymphoid                |                                           2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           1                              |             
      Depletion Lymphoid                   |                                                    2                     |             
      Epithelial Cell, Hyperplasia, Cystic |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  +  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          3  1     1              1     1  3  2     1  3  1  1  1     1   |             
      Ulcer                                |          3                                   3        3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|             
                                           | 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hair Follicle, Atrophy               |                                                                          |             
      Prepuce, Angiectasis                 |                                                                         3|             
      Prepuce, Fibrosis                    |                                                                          |             
      Prepuce, Foreign Body                |                                                                          |             
      Prepuce, Inflammation, Chronic       |                                                                         3|             
      Prepuce, Ulcer                       |          3     3                                                         |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Exudate         |                               3                                          |             
      Subcutaneous Tissue, Foreign Body    |                               3                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Distal, Joint, Femur, Arthrosis      |                                  3                                       |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          3                       2                                       |             
      Hyperplasia, Lymphoid                |                                     1  1  1                              |             
      Hyperplasia, Macrophage              |                                                 2                        |             
      Infiltration Cellular, Mixed Cell    |                3                             3     3        4            |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Embolus                      |                3                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                                 2                        |             
      Nasolacrimal Duct, Foreign Body      |                                                             2            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                    3        2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                              1                           |             
      Congestion                           |          3                                                               |             
      Hematopoietic Cell Proliferation     |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|             
                                           | 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                              1              3            |             
      Metaplasia, Osseous                  |                                     1                                    |             
      Nephropathy                          | 1  1  1     1     1  2  1  1  2  1  1  1  2     1     1  1     1  1  1   |             
      Renal Tubule, Dilatation             |          2                                                               |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      | 1  1  1     1     1  1  1  1  2  2  1  2  1  1  1  2  1  1     1  1  1  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                             3            |             
      Transitional Epithelium, Hyperplasia |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|             
                                           | 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                       2                  |             
      Eosinophilic Focus                   |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Multifocal              |                                                                      3   |             
      Infiltration Cellular, Mixed Cell    |                               2                                          |             
      Inflammation, Multifocal             |       2                                                                  |             
      Necrosis, Multifocal                 |       2  2                                         2                     |             
      Bile Duct, Cyst                      |                                           3                              |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Duct, Degeneration, Hyaline          |                                                                      3   |             
      Duct, Dilatation                     |                                                                      3   |             
      Duct, Hyperplasia, Papillary         |                                                                      3   |             
      Duct, Metaplasia                     |                                                                      2   |             
      Vein, Infiltration Cellular, Mixed   |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Mucosa, Hyperplasia, Papillary       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|             
                                           | 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Mineralization                       |                                     1                                1   |             
      Epithelium, Metaplasia, Squamous     |                                     1                                    |             
      Mucosa, Cyst                         |                                              1                       2   |             
                                            __________________________________________________________________________|             
   Tooth                                   | +     +     +     +  +                       +  +  +  +     +  +  +      |             
      Incisor, Dysplasia                   | 2     2     1        1                       3     2  3     1  1  3      |             
      Incisor, Inflammation, Chronic       |                                                                          |             
      Incisor, Inflammation, Suppurative   |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                               1                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           3                              |             
      Vacuolization Cytoplasmic, Focal     |                                                       1                  |             
      Extra Adrenal Tissue, Fibrosis       |                                                                      3   |             
      Subcapsular, Hyperplasia, Focal      |                      2                                            1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      2                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    | 1     1     1                    1                 1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |    2     2  2                    1                                      1|             
      Inflammation, Focal                  |                                                                          |             
      Follicular Cell, Hyperplasia         | 1                                         1                       2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +        +                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                         +                                                |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|             
                                           | 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                         +     +     +     +         |             
      Degeneration, Cystic                 |    3                                         3                 4         |             
      Inflammation, Suppurative            |    2                                         2     4     2               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                          3               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Dilatation                           |                         2                                                |             
      Inflammation, Chronic                |                         3  3           3                                 |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      2                                                   |             
      Germinal Epithelium, Degeneration    |                      2                                            1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +                                                               |             
      Neutrophilia                         |          2                                                               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia                   |                                                                          |             
      Inguinal, Hyperplasia                |                               2                                          |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
      Mesenteric, Angiectasis              | 1           1           1              2  3     2  1        1  1         |             
      Mesenteric, Depletion Lymphoid       |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  M  M  +  M  +  +  +  +  +  +  +  +  M  +|             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Depletion Cellular                   |                                                                          |             
      Hematopoietic Cell Proliferation     |          4     2        3     2                 3                       3|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Epithelial Cell, Hyperplasia, Cystic |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  +  M  M  M  M  +  M  M  M  M  +  +  M  M  +  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2           2     1  3              2     2  2     3        3  2  2|             
      Ulcer                                |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|             
                                           | 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hair Follicle, Atrophy               |                                                                2         |             
      Prepuce, Angiectasis                 |                                                                          |             
      Prepuce, Fibrosis                    |    3                                                                     |             
      Prepuce, Foreign Body                |                                                                          |             
      Prepuce, Inflammation, Chronic       |                               3           3                              |             
      Prepuce, Ulcer                       |                               3                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Exudate         |                                                                          |             
      Subcutaneous Tissue, Foreign Body    |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Distal, Joint, Femur, Arthrosis      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               2                          2               |             
      Hyperplasia, Lymphoid                |                                                                1         |             
      Hyperplasia, Macrophage              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                2              4                                          |             
      Alveolar Epithelium, Hyperplasia     |                         1                             1                  |             
      Artery, Embolus                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                                 1                        |             
      Nasolacrimal Duct, Foreign Body      |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                          1               |             
      Congestion                           |                         2                                                |             
      Hematopoietic Cell Proliferation     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|             
                                           | 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                2                                         1               |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 1  2  1  1  1     1  2  1        1  1  1  2  1  1  2  2     1  2     1  1|             
      Renal Tubule, Dilatation             |                3                                         2               |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      | 2  2  1  1  1  2  2  2  2  1  1  1  1  1  1  2  1  2  2  1  2  2  1  2  1|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          3               |             
      Hemorrhage                           |                               3                                          |             
      Inflammation, Chronic                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 4| 4| 4| 4| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6|                                            |            |
                                           | 0| 6| 6| 5| 5| 5| 5| 9| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +              +                                                   |  54        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  M  +              +                                                   |  51        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +              +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +              +                                                   |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +              +                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +              +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +              +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M  +              +                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +              +                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +              +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +              +                                                   |  54        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                      2                                                   |      2  2.0|
      Focal Cellular Change                |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  1.0|
      Hyperplasia, Multifocal              |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      4  2.0|
      Inflammation, Multifocal             |                                                                          |      6  1.2|
      Necrosis, Multifocal                 |                                                                          |     10  1.5|
      Bile Duct, Cyst                      |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   5        |
      Inflammation, Suppurative            | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +              +                                                   |  54        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Focal Cellular Change                |                      1                                                   |      1  1.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Duct, Degeneration, Hyaline          |                                                                          |      1  3.0|
      Duct, Dilatation                     |                                                                          |      1  3.0|
      Duct, Hyperplasia, Papillary         |                                                                          |      1  3.0|
      Duct, Metaplasia                     |                                                                          |      1  2.0|
      Vein, Infiltration Cellular, Mixed   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +              +                                                   |  53        |
      Atrophy, Focal                       |                                                                          |      1  3.0|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 4| 4| 4| 4| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6|                                            |            |
                                           | 0| 6| 6| 5| 5| 5| 5| 9| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +              +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +              +                                                   |  54        |
      Mineralization                       |                                                                          |      1  2.0|
      Mucosa, Hyperplasia, Papillary       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +              +                                                   |  54        |
      Inflammation, Focal                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      2  1.0|
      Epithelium, Metaplasia, Squamous     |                                                                          |      1  1.0|
      Mucosa, Cyst                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +                                                   |  21        |
      Incisor, Dysplasia                   |                      1                                                   |     18  1.9|
      Incisor, Inflammation, Chronic       |                                                                          |      1  3.0|
      Incisor, Inflammation, Suppurative   |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +              +                                                   |  54        |
      Inflammation, Chronic                |                                                                          |      3  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +              +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +              +                                                   |  54        |
      Cyst                                 |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  1.0|
      Extra Adrenal Tissue, Fibrosis       |                                                                          |      1  3.0|
      Subcapsular, Hyperplasia, Focal      |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +              +                                                   |  54        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +              +                                                   |  54        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +              +                                                   |  53        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +              +                                                   |  52        |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      5  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +              +                                                   |  53        |
      Cyst                                 |                                                                          |      1  2.0|
      Degeneration, Cystic                 | 1                                                                        |     12  1.3|
      Inflammation, Focal                  |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 4| 4| 4| 4| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6|                                            |            |
                                           | 0| 6| 6| 5| 5| 5| 5| 9| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +              +                                                   |  54        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Suppurative            | 3                                                                        |      1  3.0|
      Spermatocele                         | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |       +                                                                  |   5        |
      Inflammation, Chronic                |       3                                                                  |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Necrosis                             |       3                                                                  |      2  3.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  12        |
      Degeneration, Cystic                 |                                                                          |      8  3.1|
      Inflammation, Suppurative            |                                                                          |      8  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +              +                                                   |  53        |
      Inflammation, Chronic                | 3  3  2                                                                  |      6  2.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +              +                                                   |  52        |
      Dilatation                           |                                                                          |      4  2.3|
      Inflammation, Chronic                | 3  2  2                                                                  |      9  2.7|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +              +                                                   |  54        |
      Mineralization                       |                                                                          |      1  2.0|
      Germinal Epithelium, Degeneration    |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Neutrophilia                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +              +                                                   |  54        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +              +                                                   |  54        |
      Iliac, Hyperplasia                   |                                                                          |      1  3.0|
      Inguinal, Hyperplasia                |                                                                          |      2  2.0|
      Inguinal, Inflammation, Chronic      |                                                                          |      1  4.0|
      Mesenteric, Angiectasis              |                      2                                                   |     19  1.7|
      Mesenteric, Depletion Lymphoid       |                                                                          |      1  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +              M                                                   |  45        |
      Angiectasis                          | 2                                                                        |      2  2.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 4| 4| 4| 4| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6|                                            |            |
                                           | 0| 6| 6| 5| 5| 5| 5| 9| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +              +                                                   |  54        |
      Angiectasis                          |                                                                          |      1  2.0|
      Depletion Cellular                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |       2              3                                                   |     17  2.8|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +              M                                                   |  53        |
      Cyst                                 |                                                                          |      1  1.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Epithelial Cell, Hyperplasia, Cystic |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +              M                                                   |  13        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +              +                                                   |  54        |
      Inflammation, Chronic                |       2                                                                  |     25  1.8|
      Ulcer                                |                                                                          |      4  2.8|
      Hair Follicle, Atrophy               |                                                                          |      1  2.0|
      Prepuce, Angiectasis                 |                                                                          |      1  3.0|
      Prepuce, Fibrosis                    |                                                                          |      1  3.0|
      Prepuce, Foreign Body                | 2                                                                        |      1  2.0|
      Prepuce, Inflammation, Chronic       |    3  2                                                                  |      5  2.8|
      Prepuce, Ulcer                       |    3  2                                                                  |      5  2.8|
      Subcutaneous Tissue, Edema           | 3                                                                        |      1  3.0|
      Subcutaneous Tissue, Exudate         |                                                                          |      1  3.0|
      Subcutaneous Tissue, Foreign Body    |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +              +                                                   |  54        |
      Distal, Joint, Femur, Arthrosis      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +              +                                                   |  54        |
      Gliosis                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +              +                                                   |  54        |
      Congestion                           | 2                                                                        |      5  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 4| 4| 4| 4| 6| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6|                                            |            |
                                           | 0| 6| 6| 5| 5| 5| 5| 9| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      4  1.0|
      Hyperplasia, Macrophage              |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    | 2     2                                                                  |      8  2.9|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.0|
      Artery, Embolus                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +              +                                                   |  54        |
      Lumen, Exudate                       |                                                                          |      2  1.5|
      Nasolacrimal Duct, Foreign Body      |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +              +                                                   |  54        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +              +                                                   |  54        |
      Bacterium                            |                                                                          |      2  1.0|
      Congestion                           | 2                                                                        |      3  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      4  1.8|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy                          |                                                                          |     39  1.2|
      Renal Tubule, Dilatation             | 2  2  2                                                                  |      6  2.2|
      Renal Tubule, Necrosis               |       1                                                                  |      1  1.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      | 2  2  2              1                                                   |     51  1.4|
                                            __________________________________________________________________________|____________|
   Urethra                                 |    +                                                                     |   1        |
      Inflammation, Suppurative            |    3                                                                     |      1  3.0|
      Perforation                          |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +              +                                                   |  53        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|             
                                           | 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  M  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  A  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  A  A  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               2                                          |             
      Inflammation, Suppurative            |                      3                                                   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Bacterium                            |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis                             |          4                                2                              |             
      Hematopoietic Cell Proliferation     |                                                                4         |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
      Infarct                              |          3                                                               |             
      Infiltration Cellular, Mixed Cell    |                      2        1                                          |             
      Inflammation, Multifocal             | 1        1              1           2  1     1                    2      |             
      Necrosis, Multifocal                 |                                     2     1              2               |             
      Pigmentation                         |                                           2                              |             
      Artery, Media, Hypertrophy           |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization Nuclear |                                                                          |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Hyaline            | 2  2        2     1     2  1  2     2  2  2  1  1  3  2  2  3     2  3  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +     +                       +  +           +            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                                              4                           |             
      Inflammation, Suppurative            |                2     2                          4                        |             
      Fat, Necrosis                        |                                                             3            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                  1  1                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|             
                                           | 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Ulcer                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                                          |             
      Epithelium, Vacuolization            |                                                                          |             
          Cytoplasmic, Multifocal          |                                                                          |             
      Mucosa, Erosion                      |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                 +  +        +     +  +                        |             
      Incisor, Dysplasia                   |                            1  2        1     2                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                      1   |             
      Inflammation, Focal                  | 1                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
      Atrium, Thrombosis, Multiple         |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Extra Adrenal Tissue, Inflammation,  |                                                                          |             
           Suppurative                     |                                                                          |             
      Subcapsular, Hyperplasia, Focal      | 2                                      1                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                               1                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    1  1  1                          1     1              1           1  1|             
      Follicular Cell, Hyperplasia         | 2                       1     1                                         2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|             
                                           | 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                4         |             
      Inflammation, Chronic                |                      1                                                   |             
                                            __________________________________________________________________________|             
   Penis                                   | +        +           +                                                   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +        +        +                                   +     +  +|             
      Degeneration, Cystic                 |       2           2        2                                   2         |             
      Inflammation, Suppurative            |          4        2        1                                   4         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                       2                  |             
      Edema                                |                                                       2                  |             
      Inflammation, Chronic                |       3           3                             4                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                         2|             
      Inflammation, Chronic                |                2                                                        3|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                      1                                                   |             
      Necrosis, Multifocal                 |                                                                          |             
      Germinal Epithelium, Degeneration    |                            1                 3                          2|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                     +                                    |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular, Focal               |                                              1                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia                   |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                    2           2         |             
      Inguinal, Hyperplasia                |                                                                          |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
      Mesenteric, Angiectasis              |             1           2  2           1           2  2  2        3  2   |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                2         |             
      Mesenteric, Hyperplasia, Lymphoid    |                                        2                                 |             
      Mesenteric, Hyperplasia              |                      2        1                                          |             
      Mesenteric, Hyperplasia, Reticulum   |                                                                          |             
          Cell                             |                                                                          |             
      Mesenteric, Inflammation, Chronic,   |                                                                          |             
           Granulomatous                   |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|             
                                           | 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Inflammation, Suppurative|                                                                          |             
      Mesenteric, Thrombosis               |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               1                    2                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Depletion Cellular                   |                                                                          |             
      Hematopoietic Cell Proliferation     |       2  2     2  2  3        2  2  4     3  2  2  4  3  4  3  4  2  4   |             
      Hyperplasia, Lymphoid                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                                          |             
      Cyst                                 |                                        2                                 |             
      Degeneration, Cystic                 |                                                                          |             
      Depletion Lymphoid                   |                                  3                                       |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  +  +  M  +  +  +  M  M  +  M  +  M  +  M  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                             2            |             
      Exudate                              |                                                             2            |             
      Inflammation, Chronic                |       3        2     2              1  2  1  1  2  1  2     2     1      |             
      Ulcer                                |       3        3  3  3                                                   |             
      Prepuce, Inflammation, Chronic       |                                  3                                       |             
      Prepuce, Ulcer                       |                                  3                                       |             
      Subcutaneous Tissue, Lymphatic,      |                                                                          |             
          Angiectasis                      |             2                                                            |             
      Tail, Subcutaneous Tissue,           |                                                                          |             
          Inflammation, Granulomatous      |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Congestion                           |                   3                             2                        |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|             
                                           | 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    1     1              1|             
      Hyperplasia, Macrophage              |                                                                4         |             
      Infiltration Cellular, Mixed Cell    |                                                 3                        |             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation                         |                                                                4         |             
      Interstitium, Inflammation           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                       +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                           3                              |             
      Bacterium                            |       3                                         2                        |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Suppurative            |       3                                                                  |             
      Metaplasia, Osseous                  | 1                                                                        |             
      Mineralization                       |                                           3                              |             
      Necrosis, Focal                      |                                           3                              |             
      Nephropathy                          | 1  1     2  1     2  1  1  1  1     1  1  3  1     2  1  2     2  2  1  1|             
      Pelvis, Crystals                     |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation, Chronic        |                                                                          |             
      Pelvis, Mineralization               |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Crystals               |       2        1  2              3              1                        |             
      Renal Tubule, Degeneration, Hyaline  |                                                                3         |             
      Renal Tubule, Dilatation             |       1        3  2     1        3              2                        |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      | 2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  1  2  2  2  1  2  2|             
      Renal Tubule, Epithelium, Necrosis   |       2                                                                  |             
                                            __________________________________________________________________________|             
   Urethra                                 |       +                          +  +  +  +              +               |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |       3                          4                                       |             
      Bulbourethral Gland, Dilatation      |                                                                          |             
      Lumen, Crystals                      |                                     3  2  3              3               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|             
                                           | 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |       4           3                                                      |             
      Ulcer                                |                                                                          |             
      Artery, Serosa, Mineralization       | 2                                                                        |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|             
                                           | 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  I  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  M  +  +  +|             
      Parasite Metazoan                    |             1                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  M  +  +  +  M  +  +  +|             
      Inflammation, Chronic                |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  M  +  +  +  M  +  +  +|             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  M  M  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                   1                                                      |             
      Bacterium                            |                      1  1                                                |             
      Basophilic Focus                     | 3                                                                        |             
      Congestion                           |             3                                                            |             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |    2                 2  1     2                 2              2         |             
      Inflammation, Multifocal             | 1                                   1  2              1  2           1   |             
      Necrosis, Multifocal                 |                      2  2                       3  2                     |             
      Pigmentation                         |                                                          2               |             
      Artery, Media, Hypertrophy           |                                        2                                 |             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization Nuclear |                                                                          |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Hyaline            | 2     2  2  2              2     2  2  2  2           3     2        2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Inflammation, Chronic                |             2                                                            |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|             
                                           | 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Ulcer                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                     2                                    |             
      Epithelium, Vacuolization            |                                                                          |             
          Cytoplasmic, Multifocal          |                      2                                                   |             
      Mucosa, Erosion                      |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +        +           +     +  +  +              +     +        +  +|             
      Incisor, Dysplasia                   |       2                    2     1  2  2              2     1        2  2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Inflammation, Suppurative            |                   2  2  2                                                |             
      Atrium, Thrombosis, Multiple         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia, Focal                   |          2                                                               |             
      Infiltration Cellular, Mixed Cell    |                      2                                                   |             
      Extra Adrenal Tissue, Inflammation,  |                                                                          |             
           Suppurative                     |                                                                   3      |             
      Subcapsular, Hyperplasia, Focal      |       2                                1                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                         1                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                        2                                 |             
      Pars Distalis, Hyperplasia, Focal    |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       1                                                                  |             
      Follicular Cell, Hyperplasia         | 1        1                             1  1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|             
                                           | 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                   4      |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |                            +                                             |             
      Inflammation, Chronic                |                            3                                             |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic                |                            3                                             |             
                                            __________________________________________________________________________|             
   Penis                                   | +        +                                            +                  |             
      Hyperplasia                          | 3                                                                        |             
      Inflammation, Chronic                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                               +  +     +  +           +                  |             
      Degeneration, Cystic                 |                                        3  3                              |             
      Inflammation, Suppurative            |                                        2  2           3                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |    3                       3  4                 3  2           2  4      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2                 2        3                                             |             
      Inflammation, Chronic                | 3                 2        3  1                                1  4      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                            3                                             |             
      Mineralization                       |                            2        2                                    |             
      Necrosis, Multifocal                 |                            2                                             |             
      Germinal Epithelium, Degeneration    |                            2        3                                    |             
      Interstitial Cell, Hyperplasia       | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia                   |                   2     3     3                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Hyperplasia                |                                           2                              |             
      Inguinal, Inflammation, Chronic      |                                           2                              |             
      Mesenteric, Angiectasis              | 1     3  3                       2     4  2           2  2  1        3  2|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                      2   |             
      Mesenteric, Hyperplasia              |                               3                                          |             
      Mesenteric, Hyperplasia, Reticulum   |                                                                          |             
          Cell                             |                                                                          |             
      Mesenteric, Inflammation, Chronic,   |                                                                          |             
           Granulomatous                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|             
                                           | 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Inflammation, Suppurative|                      2                                                   |             
      Mesenteric, Thrombosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                                        2                                1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         2                                                |             
      Depletion Cellular                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  3     3     3           3  3                 3  3     3     2         |             
      Hyperplasia, Lymphoid                |          3                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|             
      Atypia Cellular                      |                                           2                              |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                                           2                              |             
      Depletion Lymphoid                   |                   2  2  1     1                    2              2      |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  M  +  +  +  M  M  +  +  M  +  M  M  M  +  +  +  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Exudate                              |                                                                          |             
      Inflammation, Chronic                |                3  3  3                          1              2        3|             
      Ulcer                                |                3  3  3                             3                    1|             
      Prepuce, Inflammation, Chronic       |                               3                                          |             
      Prepuce, Ulcer                       |                               3                 4                        |             
      Subcutaneous Tissue, Lymphatic,      |                                                                          |             
          Angiectasis                      |                                                                          |             
      Tail, Subcutaneous Tissue,           |                                                                          |             
          Inflammation, Granulomatous      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                      1  2                                                |             
      Congestion                           |                               3                                          |             
      Foreign Body                         |                                                                   1      |             
      Hemorrhage                           |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|             
                                           | 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                  1                                       |             
      Hyperplasia, Macrophage              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |    2              3  3  2                       2  2           2         |             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation                         |                                                                          |             
      Interstitium, Inflammation           |                2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Bacterium                            |                               2                                   3      |             
      Infiltration Cellular, Mixed Cell    |                      2                                                   |             
      Inflammation, Suppurative            |    1                          3                                   3      |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis, Focal                      |                                                                   3      |             
      Nephropathy                          | 2  2  2  2  2              1     2  2  1  1        1  3  2  1        2  1|             
      Pelvis, Crystals                     |                                                                         3|             
      Pelvis, Dilatation                   |    2                                                              2      |             
      Pelvis, Inflammation, Chronic        | 2                                1                                       |             
      Pelvis, Mineralization               | 2                                2                                       |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                         2|             
      Renal Tubule, Crystals               |                               2                                1  2      |             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
      Renal Tubule, Dilatation             |    3           2  2           2                    1              2      |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      | 2  2  2  1  1     1  1  2  2     2  2  2  2  2  2  1  2  2  2  2  2  2  2|             
      Renal Tubule, Epithelium, Necrosis   |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 | +  +           +  +        +     +  +              +           +     +   |             
      Hemorrhage                           |    3                                                                     |             
      Inflammation, Suppurative            |    3           1  2                                2           4         |             
      Bulbourethral Gland, Dilatation      |    3                                                                     |             
      Lumen, Crystals                      | 2  1                       2     3  2                                2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                  3           3                           |             
      Calculus Micro Observation Only      |                                                                         3|             
      Hyperplasia, Lymphoid                |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|             
                                           | 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |    2                          4              2     3           2  3      |             
      Ulcer                                |                                                                   3      |             
      Artery, Serosa, Mineralization       |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 3| 2| 5| 5| 3| 3| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +  +  +                                                            |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +  +                                                            |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +                                                            |  49        |
      Parasite Metazoan                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +                                                            |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +  +                                                            |  48        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     A  +  +                                                            |  46        |
      Mucosa, Inflammation, Suppurative    | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     A  +  +                                                            |  45        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +                                                            |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +                                                            |  54        |
      Autolysis                            |                                                                          |      1  1.0|
      Bacterium                            |                                                                          |      2  1.0|
      Basophilic Focus                     |       X                                                                  |      2  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Eosinophilic Focus                   |       X                                                                  |      1     |
      Fibrosis                             |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Infarct                              |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      8  1.8|
      Inflammation, Multifocal             |                                                                          |     13  1.3|
      Necrosis, Multifocal                 |       1                                                                  |      8  1.9|
      Pigmentation                         |       1                                                                  |      3  1.7|
      Artery, Media, Hypertrophy           |                                                                          |      1  2.0|
      Centrilobular, Necrosis              | 1                                                                        |      1  1.0|
      Centrilobular, Vacuolization Nuclear | 2                                                                        |      1  2.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration, Hyaline            | 2     2  1  2                                                            |     36  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 3| 2| 5| 5| 3| 3| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      3  2.7|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +                                                            |  54        |
      Inflammation, Chronic, Focal         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +  +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +                                                            |  54        |
      Mucosa, Ulcer                        | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +                                                            |  54        |
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Epithelium, Vacuolization            |                                                                          |            |
          Cytoplasmic, Multifocal          |                                                                          |      1  2.0|
      Mucosa, Erosion                      | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +     +                                                            |  18        |
      Incisor, Dysplasia                   |       2     1                                                            |     15  1.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +                                                            |  54        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Focal                  |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      3  2.0|
      Atrium, Thrombosis, Multiple         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +                                                            |  54        |
      Focal Cellular Change                |             1                                                            |      1  1.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Extra Adrenal Tissue, Inflammation,  |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Subcapsular, Hyperplasia, Focal      |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +  +                                                            |  53        |
      Hyperplasia, Focal                   |          1                                                               |      1  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  M  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +                                                            |  49        |
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 3| 2| 5| 5| 3| 3| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +                                                            |  53        |
      Degeneration, Cystic                 |                                                                          |      9  1.0|
      Follicular Cell, Hyperplasia         |          1                                                               |      9  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +  +  +                                                            |  54        |
      Granuloma Sperm                      |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   6        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  12        |
      Degeneration, Cystic                 |                                                                          |      6  2.3|
      Inflammation, Suppurative            |                                                                          |      7  2.6|
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +  +                                                            |  54        |
      Dilatation                           |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |     10  3.1|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +  +  +                                                            |  54        |
      Dilatation                           |                                                                          |      4  2.3|
      Inflammation, Chronic                |                                                                          |      8  2.4|
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +  +  +                                                            |  54        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      3  1.7|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Germinal Epithelium, Degeneration    |                                                                          |      5  2.2|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +                                                            |  54        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 3| 2| 5| 5| 3| 3| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Atypia Cellular, Focal               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +                                                            |  54        |
      Iliac, Hyperplasia                   |                                                                          |      3  2.7|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      2  2.0|
      Inguinal, Hyperplasia                |                                                                          |      1  2.0|
      Inguinal, Inflammation, Chronic      |                                                                          |      1  2.0|
      Mesenteric, Angiectasis              |       3     2                                                            |     22  2.1|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      2  2.0|
      Mesenteric, Hyperplasia              |                                                                          |      3  2.0|
      Mesenteric, Hyperplasia, Reticulum   |                                                                          |            |
          Cell                             |       2                                                                  |      1  2.0|
      Mesenteric, Inflammation, Chronic,   |                                                                          |            |
           Granulomatous                   |                                                                          |      1  4.0|
      Mesenteric, Inflammation, Suppurative|                                                                          |      1  2.0|
      Mesenteric, Thrombosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +                                                            |  51        |
      Hyperplasia, Lymphoid                |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +                                                            |  53        |
      Congestion                           |                                                                          |      1  2.0|
      Depletion Cellular                   | 2                                                                        |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |     28  2.8|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M     +  +  +                                                            |  51        |
      Atypia Cellular                      |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                                                                          |      7  1.9|
      Hyperplasia, Reticulum Cell          |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +  +                                                            |  29        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +                                                            |  54        |
      Erosion                              |                                                                          |      1  2.0|
      Exudate                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |     18  1.9|
      Ulcer                                |                                                                          |      9  2.8|
      Prepuce, Inflammation, Chronic       |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 3| 2| 5| 5| 3| 3| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Prepuce, Ulcer                       |                                                                          |      3  3.3|
      Subcutaneous Tissue, Lymphatic,      |                                                                          |            |
          Angiectasis                      |                                                                          |      1  2.0|
      Tail, Subcutaneous Tissue,           |                                                                          |            |
          Inflammation, Granulomatous      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +                                                            |  54        |
      Femur, Hyperostosis                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +                                                            |  54        |
      Congestion                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +                                                            |  54        |
      Bacterium                            |                                                                          |      2  1.5|
      Congestion                           |                                                                          |      3  2.7|
      Foreign Body                         |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      2  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      4  1.0|
      Hyperplasia, Macrophage              |                                                                          |      1  4.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      8  2.4|
      Inflammation, Granulomatous          |       3                                                                  |      1  3.0|
      Pigmentation                         |                                                                          |      1  4.0|
      Interstitium, Inflammation           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +                                                            |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +                                                            |  54        |
      Atrophy, Focal                       |                                                                          |      1  3.0|
      Bacterium                            |                                                                          |      4  2.5|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      4  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 3| 2| 5| 5| 3| 3| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    2.5%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis, Focal                      |                                                                          |      2  3.0|
      Nephropathy                          |          1  2                                                            |     38  1.5|
      Pelvis, Crystals                     |                                                                          |      1  3.0|
      Pelvis, Dilatation                   |                                                                          |      2  2.0|
      Pelvis, Inflammation, Chronic        |                                                                          |      2  1.5|
      Pelvis, Mineralization               |                                                                          |      2  2.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
      Renal Tubule, Crystals               |                                                                          |      8  1.8|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             | 1                                                                        |     13  1.9|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      | 2     2  2  2                                                            |     52  1.8|
      Renal Tubule, Epithelium, Necrosis   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |       +     +                                                            |  18        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      7  2.7|
      Bulbourethral Gland, Dilatation      |                                                                          |      1  3.0|
      Lumen, Crystals                      |       2     2                                                            |     12  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +                                                            |  54        |
      Calculus Gross Observation           |                                                                          |      2  3.0|
      Calculus Micro Observation Only      | 3                                                                        |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      8  2.9|
      Ulcer                                |                                                                          |      1  3.0|
      Artery, Serosa, Mineralization       |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia | 2                                                                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 0| 0| 7| 6| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 3| 4| 3| 6| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 2| 2| 5| 3| 2| 2| 2| 2| 7| 7| 2| 2| 2| 2| 2| 1| 5| 5| 2| 2| 6| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       A  +     +  M     +  +  +              +              M            |             
      Inflammation                         |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       3                                                                  |             
      Cyst                                 |                                                    4                     |             
      Focal Cellular Change                |                                                          2               |             
      Hematopoietic Cell Proliferation     |                                                             1            |             
      Hyperplasia, Lymphoid                | 1                                                                 1      |             
      Infiltration Cellular, Mixed Cell    |                               2                                          |             
      Inflammation, Multifocal             | 1                    1     1     1                 1  1  1           1   |             
      Necrosis, Multifocal                 |                               2              1              2            |             
      Pigmentation                         |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Hyaline            |    2                 1  1     1  1  2  1           1  2  1     2  1  2  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Inflammation, Chronic                |          2                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +     +  +     +  +  +              +              +            |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +     +  +     +  +  +              +              +            |             
      Inflammation, Focal                  |                            1                                             |             
      Mineralization                       |                            2                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Dysplasia                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +     +  +     +  +  +              +              +            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +     +  +     +  +  +              +              +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 0| 0| 7| 6| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 3| 4| 3| 6| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 2| 2| 5| 3| 2| 2| 2| 2| 7| 7| 2| 2| 2| 2| 2| 1| 5| 5| 2| 2| 6| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Subcapsular, Hyperplasia, Focal      |       2                       2                                          |             
      Unilateral, Atrophy                  |          4                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +     +  +     +  +  +              +              +            |             
      Hyperplasia, Focal                   |          2                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +     +  +     +  +  +              +              +            |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +     +  +     +  M  +              +              M            |             
      Pars Distalis, Angiectasis           |       2                                                                  |             
      Pars Distalis, Hyperplasia, Focal    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |          1  1                 1     1              1              1      |             
      Fibrosis                             |                                                                          |             
      Follicle, Cyst                       |                                                                      2  1|             
      Follicular Cell, Hyperplasia         |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Adventitia, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +     +  +     +  +  +              +              +            |             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                              +                           |             
      Inflammation, Chronic                |                                              4                           |             
      Necrosis                             |                                              3                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +     +                                            +  +   |             
      Degeneration, Cystic                 |                      2                                               4   |             
      Inflammation, Suppurative            |                                                                   4      |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +     +  +     +  +  +              +              +            |             
      Inflammation, Chronic                |                   3                                         3            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  +     +  +     +  +  +              +              +            |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +     +  +     +  +  +              +              +            |             
      Mineralization                       |                         2                                                |             
      Germinal Epithelium, Degeneration    |                         2                                                |             
      Tunic, Proliferation Connective      |                                                                          |             
          Tissue                           |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +     +  +     +  +  +              +              +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 0| 0| 7| 6| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 3| 4| 3| 6| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 2| 2| 5| 3| 2| 2| 2| 2| 7| 7| 2| 2| 2| 2| 2| 1| 5| 5| 2| 2| 6| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +     +  +     +  +  +              +           +  +           +|             
      Iliac, Hyperplasia                   |                                                                          |             
      Inguinal, Hyperplasia                |                                                             1            |             
      Mesenteric, Angiectasis              | 2     3                 2  2  2                          1              2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       M  +     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2     3  3     3  3  4           2  3     2        3            |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +     +  +     +  +  +              +              +            |             
      Depletion Lymphoid                   |       2  2                    2                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +     M  +     M  M  +              +              +            |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +     +  +  +  +  +  +  +  +  +     +  +     +  +  +     +     +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Melanocyte              |                                                 2                        |             
      Inflammation, Chronic                | 1              2  2     1  1  2  2  1                 2     2           2|             
      Metaplasia, Osseous                  |                                                                          |             
      Ulcer                                |                   4                          3              4            |             
      Hair Follicle, Atrophy               |                                                 2                       2|             
      Prepuce, Inflammation, Chronic       |                                                          3               |             
      Prepuce, Ulcer                       |                3                             3                           |             
      Subcutaneous Tissue, Edema           |                                                             2            |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +     +  +     +  +  +              +              +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +     +  +     +  +  +              +              +            |             
      Infiltration Cellular, Mixed Cell    |                                              2                           |             
      Inflammation, Focal                  |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +     +  +     +  +  +              +     +     +  +           +|             
      Congestion                           |          2                                                               |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
      Hyperplasia, Macrophage              |          2                                                               |             
      Infiltration Cellular, Mixed Cell    |                1                             1              3            |             
      Alveolar Epithelium, Hyperplasia     |                               2                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  A     +  +     +  +  +              +              +            |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +     +  +     +  +  +              +              +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 0| 0| 7| 6| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 3| 4| 3| 6| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 2| 2| 5| 3| 2| 2| 2| 2| 7| 7| 2| 2| 2| 2| 2| 1| 5| 5| 2| 2| 6| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                             +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Bacterium                            |                                                                          |             
      Congestion                           |          3                                                               |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  | 1                                                                        |             
      Necrosis                             |                                                                          |             
      Nephropathy                          | 2  2  1  2  2        1  1  2  1  2  1     1     1  1  1  2     1  2  2  2|             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Dilatation             |                2  3                          2              2            |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      | 2  2  2  2  2        2  2  2  2  2  2  2  2     2  2  2  2     2  2  2  1|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                             +            |             
      Inflammation, Suppurative            |                                                             4            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
      Inflammation, Chronic                |             1        1        1                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 3| 7| 7| 3| 7| 7| 1| 7| 7| 6| 6| 7| 3| 3| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 2| 1| 8| 8| 3| 3| 8| 3| 3| 2| 3| 3| 5| 9| 3| 8| 8| 3| 3| 3| 3| 3| 1| 3|             
                                           | 1| 0| 3| 4| 3| 1| 1| 4| 1| 1| 1| 5| 5| 4| 7| 5| 4| 4| 5| 5| 5| 5| 5| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +        +        +        +  +     +  +                 +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  M        A        +        M  +  +  +  +                 M   |             
      Inflammation                         |                                              2                           |             
      Mucosa, Hyperplasia                  |                                              3                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +        A        +        +  +     +  +                 +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  A        A        +        +  +     +  A                 +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  A        A        +        +  +     +  +                 +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +        A        +        +  +     +  +                 +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  A        A        +        +  +     +  A  +              +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  A        A        +        +  +     +  A                 +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  A        A        +        +  +     M  A                 +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  A        A        +        +  +     +  A  +              +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                   1                                                      |             
      Infiltration Cellular, Mixed Cell    |          2                                                               |             
      Inflammation, Multifocal             |                               1  1           1           1     1  1     2|             
      Necrosis, Multifocal                 |                                           2                              |             
      Pigmentation                         |                                              1                           |             
      Centrilobular, Necrosis              |          3                                                           4   |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Degeneration, Hyaline            | 1              1                 1        1                 1  1  1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  A        A        +        +  +     +  +                 +   |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  M        A        +        +  +     +  +                 +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  A        +        +        +  +     +  +                 +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  A        +        +        +  +     +  +                 +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  A        +        +        +  +     +  +                 +   |             
      Inflammation, Focal                  |                                                                          |             
      Mineralization                       |                                           2                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
      Incisor, Dysplasia                   |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +        +        +        +  +     +  +                 +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  M     +  +        +        +  +     +  +                 +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  M        +        +        +  +     +  +                 +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 3| 7| 7| 3| 7| 7| 1| 7| 7| 6| 6| 7| 3| 3| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 2| 1| 8| 8| 3| 3| 8| 3| 3| 2| 3| 3| 5| 9| 3| 8| 8| 3| 3| 3| 3| 3| 1| 3|             
                                           | 1| 0| 3| 4| 3| 1| 1| 4| 1| 1| 1| 5| 5| 4| 7| 5| 4| 4| 5| 5| 5| 5| 5| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Subcapsular, Hyperplasia, Focal      |                                                                          |             
      Unilateral, Atrophy                  |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  M        +        +        +  +     +  +                 +   |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  A        A        +        +  +     +  +                 +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +        +        +  +     +  +     +  +                 +   |             
      Cyst                                 |                                  2                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +        M        M        +  +     +  +                 +   |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       2                          2                                       |             
      Degeneration, Cystic                 | 1              1                                1        2     1  2      |             
      Fibrosis                             |                                                          1               |             
      Follicle, Cyst                       |                            1                                             |             
      Follicular Cell, Hyperplasia         |                   1              1        1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Adventitia, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +        +        +        +  +     +  +                 +   |             
      Granuloma Sperm                      |                                        3                                 |             
                                            __________________________________________________________________________|             
   Penis                                   |             +        +                             +                     |             
      Inflammation, Chronic                |                      3                             3                     |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                                      +     +               |             
      Degeneration, Cystic                 |             3                                                            |             
      Inflammation, Suppurative            |                                                          4               |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +        +        +        +  +     +  +                 +   |             
      Inflammation, Chronic                |                      4        3                 3                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +        +        +        +  +     +                    +   |             
      Dilatation                           | 4                                                                        |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +        +        +        +  +     +  +                 +   |             
      Mineralization                       |                                                                          |             
      Germinal Epithelium, Degeneration    |                                                                          |             
      Tunic, Proliferation Connective      |                                                                          |             
          Tissue                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +        +        +        +  +     +  +                 +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 3| 7| 7| 3| 7| 7| 1| 7| 7| 6| 6| 7| 3| 3| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 2| 1| 8| 8| 3| 3| 8| 3| 3| 2| 3| 3| 5| 9| 3| 8| 8| 3| 3| 3| 3| 3| 1| 3|             
                                           | 1| 0| 3| 4| 3| 1| 1| 4| 1| 1| 1| 5| 5| 4| 7| 5| 4| 4| 5| 5| 5| 5| 5| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Neutrophil              |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  M  +  +  M        +        +  +     +  +        +        +  +|             
      Iliac, Hyperplasia                   |                               3                                          |             
      Inguinal, Hyperplasia                |       2                       2                                          |             
      Mesenteric, Angiectasis              |          1     3                                            2           3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  M        M        +        +  +     M  M                 +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3  3  4  3           2     3     2  2  4  3  2     3              3  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M  +  +  M        M        +        +  +     +  +                 +   |             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  M  M        +        M        +  +     M  +                 M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +        +  +  +   |             
      Fibrosis                             |       3                                                                  |             
      Hyperplasia, Melanocyte              |                                                                          |             
      Inflammation, Chronic                | 1     3  1  2              1     1  1  1        3  3           2  2  1   |             
      Metaplasia, Osseous                  |                                                                   2      |             
      Ulcer                                |       3                                         3                        |             
      Hair Follicle, Atrophy               |                                                                          |             
      Prepuce, Inflammation, Chronic       |                                                                2         |             
      Prepuce, Ulcer                       |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +        +        +        +  +     +  +                 +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +        +        +        +  +     +  +                 +   |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +        +        +     +  +  +  +  +  +  +     +        +   |             
      Congestion                           |             3        3                                                   |             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Hyperplasia, Macrophage              |                                              2                           |             
      Infiltration Cellular, Mixed Cell    |                               2                 3  2                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +        +        +        +  +     +  +                 +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +        +        +        +  +     +  +                 +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 5| 3| 7| 7| 3| 7| 7| 1| 7| 7| 6| 6| 7| 3| 3| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 2| 1| 8| 8| 3| 3| 8| 3| 3| 2| 3| 3| 5| 9| 3| 8| 8| 3| 3| 3| 3| 3| 1| 3|             
                                           | 1| 0| 3| 4| 3| 1| 1| 4| 1| 1| 1| 5| 5| 4| 7| 5| 4| 4| 5| 5| 5| 5| 5| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.25%                                  | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Bacterium                            |             3                                                            |             
      Congestion                           |                                                                          |             
      Inflammation, Suppurative            |             4                                                            |             
      Metaplasia, Osseous                  |                                     1                                    |             
      Necrosis                             |             4                                                            |             
      Nephropathy                          | 2     1  1     1  1     1  1        2  2  1  1        1  1  1  2  1  2  2|             
      Papilla, Necrosis                    |             4                                                            |             
      Renal Tubule, Dilatation             |                                                 2  2                     |             
      Renal Tubule, Hyperplasia            |                         2                                                |             
      Renal Tubule, Mineralization         |                                                    1                     |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      | 2  2  1  2     2  2     2  2  1  2  2  2  1  1  1  2  1  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |                               +                                          |             
      Inflammation, Suppurative            |                               3                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               2                                          |             
      Hyperplasia, Lymphoid                |                                                                2         |             
      Inflammation, Chronic                |                               2     1                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 5| 7| 0| 4| 4| 7| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 9| 3| 9| 6| 6| 3| 6|                                            |            |
                                           | 3| 3| 3| 8| 5| 3| 3| 3| 5| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +     +                                                         |  22        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +     +                                                         |  16        |
      Inflammation                         |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +     +                                                         |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +     M                                                         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +     +                                                         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +     +                                                         |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +     M                                                         |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +     M                                                         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +     M                                                         |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +     M                                                         |  19        |
                                            __________________________________________________________________________|____________|
   Liver                                   |          +  +  +        +                                                |  53        |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1  4.0|
      Focal Cellular Change                |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      2  2.0|
      Inflammation, Multifocal             |             1                                                            |     16  1.1|
      Necrosis, Multifocal                 |                                                                          |      4  1.8|
      Pigmentation                         |                                                                          |      1  1.0|
      Centrilobular, Necrosis              |                                                                          |      2  3.5|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Degeneration, Hyaline            |          1  1           2                                                |     24  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +  +                                                         |  21        |
      Duct, Dilatation                     |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +     +                                                         |  20        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +     +                                                         |  21        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +     +                                                         |  21        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +     +                                                         |  21        |
      Inflammation, Focal                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Incisor, Dysplasia                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 5| 7| 0| 4| 4| 7| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 9| 3| 9| 6| 6| 3| 6|                                            |            |
                                           | 3| 3| 3| 8| 5| 3| 3| 3| 5| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +     +                                                         |  22        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +     +                                                         |  22        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +     +                                                         |  21        |
      Subcapsular, Hyperplasia, Focal      |                                                                          |      2  2.0|
      Unilateral, Atrophy                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +     +                                                         |  21        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +     +                                                         |  20        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +     M                                                         |  22        |
      Cyst                                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +     M                                                         |  17        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +  +        +                                                |  54        |
      Cyst                                 |                                                                          |      2  2.0|
      Degeneration, Cystic                 |          2                                                               |     13  1.2|
      Fibrosis                             |                                                                          |      1  1.0|
      Follicle, Cyst                       |                         1                                                |      4  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                +                                                         |   1        |
      Adventitia, Hemorrhage               |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +     +                                                         |  22        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   4        |
      Inflammation, Chronic                |                                                                          |      3  3.3|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   7        |
      Degeneration, Cystic                 |                                                                          |      3  3.0|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |          +     +                                                         |  22        |
      Inflammation, Chronic                |                                                                          |      5  3.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +  +  +                                                         |  23        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 5| 7| 0| 4| 4| 7| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 9| 3| 9| 6| 6| 3| 6|                                            |            |
                                           | 3| 3| 3| 8| 5| 3| 3| 3| 5| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Dilatation                           |             4                                                            |      2  4.0|
      Inflammation, Chronic                |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |          +     +                                                         |  22        |
      Mineralization                       |                                                                          |      1  2.0|
      Germinal Epithelium, Degeneration    |                                                                          |      1  2.0|
      Tunic, Proliferation Connective      |                                                                          |            |
          Tissue                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +     +                                                         |  22        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +     +                                                         |  27        |
      Iliac, Hyperplasia                   |                                                                          |      1  3.0|
      Inguinal, Hyperplasia                |                1                                                         |      4  1.5|
      Mesenteric, Angiectasis              |                                                                          |     11  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +     +                                                         |  17        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  +  +        +                                                |  53        |
      Hematopoietic Cell Proliferation     |          3                                                               |     25  2.8|
      Hyperplasia, Lymphoid                |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +     +                                                         |  19        |
      Depletion Lymphoid                   |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +     M                                                         |  11        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +  +        +                                                |  43        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperplasia, Melanocyte              |                                                                          |      1  2.0|
      Inflammation, Chronic                |          1  3  2                                                         |     27  1.7|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      5  3.4|
      Hair Follicle, Atrophy               |                                                                          |      2  2.0|
      Prepuce, Inflammation, Chronic       |                                                                          |      2  2.5|
      Prepuce, Ulcer                       |                3                                                         |      3  3.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Fibrosis        |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +     +                                                         |  22        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 5| 7| 0| 4| 4| 7| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 9| 3| 9| 6| 6| 3| 6|                                            |            |
                                           | 3| 3| 3| 8| 5| 3| 3| 3| 5| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    1.25%                                  | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +     +                                                         |  22        |
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Inflammation, Focal                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +  +  +                                                         |  32        |
      Congestion                           |                                                                          |      3  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Macrophage              |                                                                          |      2  2.0|
      Infiltration Cellular, Mixed Cell    |                1                                                         |      7  1.9|
      Alveolar Epithelium, Hyperplasia     |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +     +                                                         |  21        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +     +                                                         |  22        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +  +        +                                                |  53        |
      Atrophy, Focal                       |          3                                                               |      1  3.0|
      Bacterium                            |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Metaplasia, Osseous                  |                                                                          |      2  1.0|
      Necrosis                             |                                                                          |      1  4.0|
      Nephropathy                          |          2  1           1                                                |     41  1.4|
      Papilla, Necrosis                    |                                                                          |      1  4.0|
      Renal Tubule, Dilatation             |                3                                                         |      7  2.3|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |      1  1.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |          1  2  2        2                                                |     48  1.8|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Inflammation, Suppurative            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +  +        +                                                |  53        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      6  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 7| 6| 6| 7| 7| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 4| 7| 5| 3| 0| 3| 2| 5| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 4| 1| 8| 4| 1| 1| 2| 7| 4| 2| 2| 8| 2| 5| 2| 2| 9| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.625%                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +  +  +  +     +     +  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Gallbladder                             |             +  +  +  +     +     +  +        A     A        +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +  +  +  +     +     +  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +  +  +  +     +     +  +        A     A        +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +  +  +  +     +     +  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +  +  +  +     +     +  +        A     +        +            |             
      Prolapse                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +  +  +  +     +     +  +        A     +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +  +  +  +     +     +  +        A     +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +  +  +  +     +     +  +        A     A        +            |             
      Perforation                          |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +  +  +  +     +     +  +        A     A        +            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                             3            |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Hyperplasia, Lymphoid                |       1                                   2                              |             
      Infiltration Cellular, Mixed Cell    |                                  2                 2                     |             
      Inflammation, Multifocal             |          1                       1                       2               |             
      Necrosis, Multifocal                 |                                                    2                     |             
      Pigmentation                         |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Cytomegaly               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Inflammation, Chronic                |                                  4                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +  +  +  +  +  +     +  +        A     +        +            |             
      Atrophy, Focal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +  +  +  +     +     +  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +  +  +  +     +     +  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +  +  +  +     +     +  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +  +  +  +     +     +  +        A     +        +            |             
      Erosion                              |                   2                                                      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +  +                       +            |             
      Incisor, Dysplasia                   |                                  2  3                       1            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +  +  +  +     +     +  +        A     +        +            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +  +  +  +  +  +     +  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +  +  +  +     +     +  +        A     +        +            |             
      Hyperplasia, Focal                   |                                                             2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +  +  +  +  +  +     +  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +  +  +  +     +     +  +        A     +        +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 7| 6| 6| 7| 7| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 4| 7| 5| 3| 0| 3| 2| 5| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 4| 1| 8| 4| 1| 1| 2| 7| 4| 2| 2| 8| 2| 5| 2| 2| 9| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.625%                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +  +  M  +     +     M  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +  +  +  +     +     +  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2           1                                      1                 2  1|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                1                                      2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |             +  +  +  +     +     +  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Penis                                   |                                           +                              |             
      Fibrosis                             |                                           4                              |             
      Inflammation, Chronic                |                                           4                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                 +                       +                 +   |             
      Degeneration, Cystic                 |          2                                         3                     |             
      Inflammation, Suppurative            |          2                 4                                         4   |             
                                            __________________________________________________________________________|             
   Prostate                                |             +  +  +  +     +     +  +        A     M        +            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |             +  +  +  +     +     +  +  +     A     +        +            |             
      Dilatation                           |                                        3                                 |             
      Inflammation, Chronic                |                                  3     3           4                     |             
      Epithelium, Hyperplasia              |                                  3                                       |             
                                            __________________________________________________________________________|             
   Testes                                  |             +  +  +  +     +     +  +        A     +  +     +            |             
      Mineralization                       |                                                                          |             
      Germinal Epithelium, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   +     +                                                |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +  +  +  +     +     +  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +  +  +  +  +     +  +        A     +        +     +  +   |             
      Inguinal, Hyperplasia                |                                                    2                     |             
      Mesenteric, Angiectasis              |    2        2           1  2        2                             2  2   |             
      Mesenteric, Hyperplasia, Lymphoid    |    2                 2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +  +  +  +     M     M  +        A     +        +            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                            3        2                                    |             
      Hematopoietic Cell Proliferation     |       2  3  3        2  3        2                    2  2  3           3|             
                                            __________________________________________________________________________|             
   Thymus                                  |             +  +  +  +     +     +  +        A     +        +            |             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 7| 6| 6| 7| 7| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 4| 7| 5| 3| 0| 3| 2| 5| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 4| 1| 8| 4| 1| 1| 2| 7| 4| 2| 2| 8| 2| 5| 2| 2| 9| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.625%                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  +  +  M     M     +  M        M     M        +            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        A     +  +  +  +  +  +     +|             
      Exudate                              |                                                                          |             
      Inflammation, Chronic                |    1  2  2  2  2  1        2                          2  2     1        3|             
      Metaplasia, Osseous                  |                                                       3                  |             
      Ulcer                                |                                                                         3|             
      Hair Follicle, Atrophy               |                                                                          |             
      Prepuce, Foreign Body                |                                                                          |             
      Prepuce, Inflammation, Chronic       |                                                                          |             
      Prepuce, Ulcer                       |                                                    4                     |             
      Subcutaneous Tissue, Edema           |                   2                                                      |             
      Subcutaneous Tissue, Fibrosis        |       3                                                                  |             
      Subcutaneous Tissue, Foreign Body    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +  +  +  +     +     +  +        A     +        +            |             
      Distal, Joint, Femur, Arthrosis      |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +  +  +  +     +     +  +        A     +        +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +  +  +  +     +     +  +        A     +        +            |             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                    2                     |             
      Interstitium, Inflammation           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +  +  +  +     +     +  +        A     +        +            |             
      Lumen, Exudate                       |                                                                          |             
      Lumen, Foreign Body                  |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                            2                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +  +  +  +     +     +  +        A     +        +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                                                                      2   |             
      Nephropathy                          | 1  1  1  1  1  1     1  1     1        1  1     1     1  3  2  1  1  3  1|             
      Papilla, Necrosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 7| 6| 6| 7| 7| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 4| 7| 5| 3| 0| 3| 2| 5| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 4| 1| 8| 4| 1| 1| 2| 7| 4| 2| 2| 8| 2| 5| 2| 2| 9| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.625%                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Degeneration, Hyaline  |                   2                                                      |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      | 2  2  2  1  1  1  1  1  1  1  2  2  2  2  2     2  2  2  1  1  2  2  1  2|             
      Renal Tubule, Epithelium, Necrosis   |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |    +                                                              +      |             
      Fibrosis                             |    2                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
      Bulbourethral Gland, Dilatation      |    3                                                              3      |             
      Bulbourethral Gland, Fibrosis        |                                                                   1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Inflammation, Chronic                |       1                       1                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 9| 9| 2| 6| 0| 3| 3| 3| 3| 9| 3| 9| 3| 1| 8| 3| 3| 3|             
                                           | 9| 5| 5| 5| 5| 5| 5| 7| 7| 4| 7| 1| 5| 5| 5| 5| 3| 5| 9| 5| 4| 2| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.625%                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                    +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +                    +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +                    +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                      +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      +  +  +  +  +              +     +     +  +         |             
      Prolapse                             |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +                    +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                      +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +  +  +  +  +              +     +     +  +         |             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Fatty Change                         |                                        1                                 |             
      Hematopoietic Cell Proliferation     |                            1                                             |             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Infiltration Cellular, Mixed Cell    |                               2                 2        2               |             
      Inflammation, Multifocal             |             1  1  2  1        1           2  1                          1|             
      Necrosis, Multifocal                 |                   1                             2     2     1           1|             
      Pigmentation                         |                                           2                              |             
      Centrilobular, Necrosis              |                                                          1               |             
      Hepatocyte, Cytomegaly               |                                           2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +                    +  +  +  +  +              +     +  +  +  +         |             
      Atrophy, Focal                       |                                                          1               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +                    +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +                    +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                      +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                      +  +  +  +  +              +     +     +  +         |             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
      Incisor, Dysplasia                   |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +                    +  +  +  +  +              +     +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +                    +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                      +  +  +  +  +              +     +     +  +         |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                      +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                    +  +  +  +  +              +     +     +  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 9| 9| 2| 6| 0| 3| 3| 3| 3| 9| 3| 9| 3| 1| 8| 3| 3| 3|             
                                           | 9| 5| 5| 5| 5| 5| 5| 7| 7| 4| 7| 1| 5| 5| 5| 5| 3| 5| 9| 5| 4| 2| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.625%                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +                    +  +  +  +  M              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +                    +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    1        1     1                       2                       1  1  1|             
      Follicle, Cyst                       |                                                 1                        |             
      Follicular Cell, Hyperplasia         |       2           1                 2     2        1              1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +                    +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                                                        +   |             
      Degeneration, Cystic                 |             3                                                            |             
      Inflammation, Suppurative            |             2                                                        3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +                    +  +  +  +  +              +     +     +  +         |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +              +  +  +  +  +              +     +     +  +         |             
      Dilatation                           |       3                                                                  |             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +                    +  +  +  +  +              +     +     +  +         |             
      Mineralization                       |                               2                                          |             
      Germinal Epithelium, Degeneration    |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                          +               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +                    +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +        +  +  +  +  +              +  +  +  +  +  +        +|             
      Inguinal, Hyperplasia                |                                                                          |             
      Mesenteric, Angiectasis              | 2  2     2  2        2                             1     2     2        1|             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +  +  +  +  +              +     +     +  +         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                  2                                       |             
      Hematopoietic Cell Proliferation     | 3           2     2  3  3  3  2           2     3     3  4  4  2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +                    +  +  +  M  +              +     +     +  +         |             
      Cyst                                 |                                                       1                  |             
      Depletion Lymphoid                   |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 9| 9| 2| 6| 0| 3| 3| 3| 3| 9| 3| 9| 3| 1| 8| 3| 3| 3|             
                                           | 9| 5| 5| 5| 5| 5| 5| 7| 7| 4| 7| 1| 5| 5| 5| 5| 3| 5| 9| 5| 4| 2| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.625%                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                    +  M  M  M  M              +     M     M  +         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +|             
      Exudate                              | 2                                                                        |             
      Inflammation, Chronic                | 2           1  1     2  3  1  2     1           2  2        3           3|             
      Metaplasia, Osseous                  |                                                                          |             
      Ulcer                                |                         3                       3           3            |             
      Hair Follicle, Atrophy               |                                                                2         |             
      Prepuce, Foreign Body                |                                                                      2   |             
      Prepuce, Inflammation, Chronic       |                                                                      2   |             
      Prepuce, Ulcer                       |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
      Subcutaneous Tissue, Foreign Body    |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +                    +  +  +  +  +              +     +     +  +         |             
      Distal, Joint, Femur, Arthrosis      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                    +  +  +  +  +              +     +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +                 +  +  +  +  +        +  +  +     +     +  +         |             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                 2                        |             
      Interstitium, Inflammation           |                            1                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +                    +  +  +  +  +              +     +     +  +         |             
      Lumen, Exudate                       |                            2                                   2         |             
      Lumen, Foreign Body                  |                            1                                             |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +                    +  +  +  +  +              +     +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 1  1  2  1  2  1  1  2  2  2  3  1  1  1  2  1  1  2     1     2  1  1  1|             
      Papilla, Necrosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 9| 9| 2| 6| 0| 3| 3| 3| 3| 9| 3| 9| 3| 1| 8| 3| 3| 3|             
                                           | 9| 5| 5| 5| 5| 5| 5| 7| 7| 4| 7| 1| 5| 5| 5| 5| 3| 5| 9| 5| 4| 2| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.625%                                 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      | 2  1  1  2  2  2  2  2  1  2  1     2  2  1  2  2  2  2  2  2  2  2  2  2|             
      Renal Tubule, Epithelium, Necrosis   |                                  1                                       |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                  +                                       |             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                  2                                       |             
      Bulbourethral Gland, Dilatation      |                                                                          |             
      Bulbourethral Gland, Fibrosis        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                  2                                       |             
      Transitional Epithelium, Hyperplasia |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 4| 7| 3| 3| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 6| 6| 6| 3| 4| 9| 6| 6| 6|                                            |            |
                                           | 5| 3| 3| 3| 5| 6| 4| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.625%                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +                                                      |  21        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                A  +                                                      |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                A  +                                                      |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                A  +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                A  +                                                      |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                A  +                                                      |  19        |
      Prolapse                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                A  +                                                      |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                A  +                                                      |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                A  M                                                      |  17        |
      Perforation                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                A  +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +           +  +  +                                                      |  53        |
      Basophilic Focus                     |             3                                                            |      2  3.0|
      Fatty Change                         | 1                                                                        |      2  1.0|
      Hematopoietic Cell Proliferation     |                   2                                                      |      3  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      3  1.7|
      Infiltration Cellular, Mixed Cell    |                                                                          |      5  2.0|
      Inflammation, Multifocal             |                                                                          |     11  1.3|
      Necrosis, Multifocal                 |                                                                          |      6  1.5|
      Pigmentation                         |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  1.0|
      Hepatocyte, Cytomegaly               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   3        |
      Inflammation, Chronic                |                   3                                                      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +                                                      |  23        |
      Atrophy, Focal                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +  +                                                      |  21        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +                                                      |  21        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +                                                      |  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +                                                      |  20        |
      Erosion                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
      Incisor, Dysplasia                   |                                                                          |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +                                                      |  21        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 106                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 4| 7| 3| 3| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 6| 6| 6| 3| 4| 9| 6| 6| 6|                                            |            |
                                           | 5| 3| 3| 3| 5| 6| 4| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.625%                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +  +                                                      |  22        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +  +                                                      |  20        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +  +                                                      |  21        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +                                                      |  21        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +  +                                                      |  18        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +                                                      |  21        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +           +  +  +                                                      |  53        |
      Degeneration, Cystic                 |             2                                                            |     13  1.3|
      Follicle, Cyst                       |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      8  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +  +                                                      |  21        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Fibrosis                             |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   6        |
      Degeneration, Cystic                 |                                                                          |      3  2.7|
      Inflammation, Suppurative            |                                                                          |      5  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                +  +                                                      |  20        |
      Inflammation, Chronic                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +  +                                                      |  23        |
      Dilatation                           |                3                                                         |      3  3.0|
      Inflammation, Chronic                |                                                                          |      3  3.3|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                +  +                                                      |  22        |
      Mineralization                       |                                                                          |      1  2.0|
      Germinal Epithelium, Degeneration    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +                                                      |  21        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +  +  +                                                      |  33        |
      Inguinal, Hyperplasia                |                                                                          |      1  2.0|
      Mesenteric, Angiectasis              |             2                                                            |     17  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 107                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 4| 7| 3| 3| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 6| 6| 6| 3| 4| 9| 6| 6| 6|                                            |            |
                                           | 5| 3| 3| 3| 5| 6| 4| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.625%                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +  +  +                                                      |  19        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +  +  +                                                      |  53        |
      Depletion Cellular                   |                                                                          |      3  2.3|
      Hematopoietic Cell Proliferation     |                2  3                                                      |     25  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                M  +                                                      |  19        |
      Cyst                                 |                                                                          |      1  1.0|
      Depletion Lymphoid                   |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                M  M                                                      |   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    |             +  +  +                                                      |  45        |
      Exudate                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                3                                                         |     24  1.9|
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
      Ulcer                                |                4                                                         |      5  3.2|
      Hair Follicle, Atrophy               |                                                                          |      1  2.0|
      Prepuce, Foreign Body                |                                                                          |      1  2.0|
      Prepuce, Inflammation, Chronic       |                                                                          |      1  2.0|
      Prepuce, Ulcer                       |                                                                          |      1  4.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  3.0|
      Subcutaneous Tissue, Foreign Body    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +                                                      |  21        |
      Distal, Joint, Femur, Arthrosis      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +                                                      |  21        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +                                                      |  25        |
      Congestion                           |                2  2                                                      |      2  2.0|
      Edema                                |                1                                                         |      1  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      2  2.0|
      Interstitium, Inflammation           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +                                                      |  21        |
      Lumen, Exudate                       |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 108                                                               
NTP Experiment-Test: 05025-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENE GLYCOL                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 09:01:29  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 4| 4| 7| 3| 3| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 6| 6| 6| 3| 4| 9| 6| 6| 6|                                            |            |
                                           | 5| 3| 3| 3| 5| 6| 4| 3| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0.625%                                 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lumen, Foreign Body                  |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +  +                                                      |  21        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +           +  +  +                                                      |  53        |
      Angiectasis                          | 1                                                                        |      1  1.0|
      Inflammation, Suppurative            |                   4                                                      |      1  4.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Nephropathy                          | 1           1                                                            |     44  1.3|
      Papilla, Necrosis                    |                   4                                                      |      1  4.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      1  2.0|
      Renal Tubule, Dilatation             |                2  2                                                      |      2  2.0|
      Renal Tubule, Mineralization         |                2                                                         |      1  2.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      | 2           2                                                            |     50  1.7|
      Renal Tubule, Epithelium, Necrosis   |                1                                                         |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                   +                                                      |   4        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                   3                                                      |      2  2.5|
      Bulbourethral Gland, Dilatation      |                                                                          |      2  3.0|
      Bulbourethral Gland, Fibrosis        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +           +  +  +                                                      |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                   3                                                      |      4  1.8|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 109                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.